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Conserved domains on  [gi|5902034|ref|NP_008993|]
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periodic tryptophan protein 1 homolog isoform 1 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
199-462 5.24e-27

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 112.70  E-value: 5.24e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5902034  199 SPDdstGNYIAVGNMTPVIEVWDLDivdSLEPVFTLgsklskkkkkkgkksssaEGHTDAVLDLSWN---KLirnvLASA 275
Cdd:COG2319 129 SPD---GKTLASGSADGTVRLWDLA---TGKLLRTL------------------TGHSGAVTSVAFSpdgKL----LASG 180

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5902034  276 SADNTVILWDMSLGKPAASLAVHTDKVQTLQFHPfEAQTLISGSYDKSVALYDCRSPDESHRMWRFSGQIERVTwnhFSP 355
Cdd:COG2319 181 SDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP-DGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVA---FSP 256

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5902034  356 -CHFLAST-DDGFVYNLDARSDKPIFTLNAHNDEISGLDLS--SQIkgcLVTASADKYVKIWDILGDRP--SLVHSRDMK 429
Cdd:COG2319 257 dGRLLASGsADGTVRLWDLATGELLRTLTGHSGGVNSVAFSpdGKL---LASGSDDGTVRLWDLATGKLlrTLTGHTGAV 333

                       250       260       270
                ....*....|....*....|....*....|...
gi 5902034  430 MGVLFcsscCPDLPFIyAFGGQKEGLRVWDIST 462
Cdd:COG2319 334 RSVAF----SPDGKTL-ASGSDDGTVRLWDLAT 361
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
199-462 5.24e-27

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 112.70  E-value: 5.24e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5902034  199 SPDdstGNYIAVGNMTPVIEVWDLDivdSLEPVFTLgsklskkkkkkgkksssaEGHTDAVLDLSWN---KLirnvLASA 275
Cdd:COG2319 129 SPD---GKTLASGSADGTVRLWDLA---TGKLLRTL------------------TGHSGAVTSVAFSpdgKL----LASG 180

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5902034  276 SADNTVILWDMSLGKPAASLAVHTDKVQTLQFHPfEAQTLISGSYDKSVALYDCRSPDESHRMWRFSGQIERVTwnhFSP 355
Cdd:COG2319 181 SDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP-DGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVA---FSP 256

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5902034  356 -CHFLAST-DDGFVYNLDARSDKPIFTLNAHNDEISGLDLS--SQIkgcLVTASADKYVKIWDILGDRP--SLVHSRDMK 429
Cdd:COG2319 257 dGRLLASGsADGTVRLWDLATGELLRTLTGHSGGVNSVAFSpdGKL---LASGSDDGTVRLWDLATGKLlrTLTGHTGAV 333

                       250       260       270
                ....*....|....*....|....*....|...
gi 5902034  430 MGVLFcsscCPDLPFIyAFGGQKEGLRVWDIST 462
Cdd:COG2319 334 RSVAF----SPDGKTL-ASGSDDGTVRLWDLAT 361
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 253-486 4.69e-26

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 107.42  E-value: 4.69e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5902034  253 EGHTDAVLDLSWNKlIRNVLASASADNTVILWDMSLGKPAASLAVHTDKVQTLQFHPFeAQTLISGSYDKSVALYDCRSP 332
Cdd:cd00200   6 KGHTGGVTCVAFSP-DGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASAD-GTYLASGSSDKTIRLWDLETG 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5902034  333 DESHrmwRFSGQIERVTWNHFSPCHFLAST--DDGFVYNLDARSDKPIFTLNAHNDEISGLDLSSQiKGCLVTASADKYV 410
Cdd:cd00200  84 ECVR---TLTGHTSYVSSVAFSPDGRILSSssRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPD-GTFVASSSQDGTI 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5902034  411 KIWDILGDRPSLVHSrDMKMGVlFCSSCCPDLPFIYAFGGQKEgLRVWDISTVSSVNE-----------AFGRRERLVLG 479
Cdd:cd00200 160 KLWDLRTGKCVATLT-GHTGEV-NSVAFSPDGEKLLSSSSDGT-IKLWDLSTGKCLGTlrghengvnsvAFSPDGYLLAS 236


                ....*..
gi 5902034  480 SARNSSI 486
Cdd:cd00200 237 GSEDGTI 243
PTZ00420 PTZ00420
coronin; Provisional
 253-328 2.50e-06

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 49.95  E-value: 2.50e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5902034   253 EGHTDAVLDLSWNKLIRNVLASASADNTVILWDM--------SLGKPAASLAVHTDKVQTLQFHPFEAQTLISGSYDKSV 324
Cdd:PTZ00420  71 KGHTSSILDLQFNPCFSEILASGSEDLTIRVWEIphndesvkEIKDPQCILKGHKKKISIIDWNPMNYYIMCSSGFDSFV 150


                 ....
gi 5902034   325 ALYD 328
Cdd:PTZ00420 151 NIWD 154
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 374-414 2.55e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.14  E-value: 2.55e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 5902034     374 SDKPIFTLNAHNDEISGLDLSSQIKgCLVTASADKYVKIWD 414
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGK-YLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
376-414 4.53e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.71  E-value: 4.53e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 5902034    376 KPIFTLNAHNDEISGLDLSSQiKGCLVTASADKYVKIWD 414
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPD-GKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
199-462 5.24e-27

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 112.70  E-value: 5.24e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5902034  199 SPDdstGNYIAVGNMTPVIEVWDLDivdSLEPVFTLgsklskkkkkkgkksssaEGHTDAVLDLSWN---KLirnvLASA 275
Cdd:COG2319 129 SPD---GKTLASGSADGTVRLWDLA---TGKLLRTL------------------TGHSGAVTSVAFSpdgKL----LASG 180

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5902034  276 SADNTVILWDMSLGKPAASLAVHTDKVQTLQFHPfEAQTLISGSYDKSVALYDCRSPDESHRMWRFSGQIERVTwnhFSP 355
Cdd:COG2319 181 SDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP-DGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVA---FSP 256

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5902034  356 -CHFLAST-DDGFVYNLDARSDKPIFTLNAHNDEISGLDLS--SQIkgcLVTASADKYVKIWDILGDRP--SLVHSRDMK 429
Cdd:COG2319 257 dGRLLASGsADGTVRLWDLATGELLRTLTGHSGGVNSVAFSpdGKL---LASGSDDGTVRLWDLATGKLlrTLTGHTGAV 333

                       250       260       270
                ....*....|....*....|....*....|...
gi 5902034  430 MGVLFcsscCPDLPFIyAFGGQKEGLRVWDIST 462
Cdd:COG2319 334 RSVAF----SPDGKTL-ASGSDDGTVRLWDLAT 361
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 253-486 4.69e-26

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 107.42  E-value: 4.69e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5902034  253 EGHTDAVLDLSWNKlIRNVLASASADNTVILWDMSLGKPAASLAVHTDKVQTLQFHPFeAQTLISGSYDKSVALYDCRSP 332
Cdd:cd00200   6 KGHTGGVTCVAFSP-DGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASAD-GTYLASGSSDKTIRLWDLETG 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5902034  333 DESHrmwRFSGQIERVTWNHFSPCHFLAST--DDGFVYNLDARSDKPIFTLNAHNDEISGLDLSSQiKGCLVTASADKYV 410
Cdd:cd00200  84 ECVR---TLTGHTSYVSSVAFSPDGRILSSssRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPD-GTFVASSSQDGTI 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5902034  411 KIWDILGDRPSLVHSrDMKMGVlFCSSCCPDLPFIYAFGGQKEgLRVWDISTVSSVNE-----------AFGRRERLVLG 479
Cdd:cd00200 160 KLWDLRTGKCVATLT-GHTGEV-NSVAFSPDGEKLLSSSSDGT-IKLWDLSTGKCLGTlrghengvnsvAFSPDGYLLAS 236


                ....*..
gi 5902034  480 SARNSSI 486
Cdd:cd00200 237 GSEDGTI 243
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 253-414 5.02e-26

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 107.42  E-value: 5.02e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5902034  253 EGHTDAVLDLSWNKlIRNVLASASADNTVILWDMSLGKPAASLAVHTDKVQTLQFHPfEAQTLISGSYDKSVALYDCRSP 332
Cdd:cd00200 132 RGHTDWVNSVAFSP-DGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSP-DGEKLLSSSSDGTIKLWDLSTG 209

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5902034  333 DESHRmwrFSGQIERVTWNHFSPCH--FLASTDDGFVYNLDARSDKPIFTLNAHNDEISGLDLSSQIKgCLVTASADKYV 410
Cdd:cd00200 210 KCLGT---LRGHENGVNSVAFSPDGylLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGK-RLASGSADGTI 285


                ....
gi 5902034  411 KIWD 414
Cdd:cd00200 286 RIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 203-459 1.79e-24

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 103.18  E-value: 1.79e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5902034  203 STGNYIAVGNMTPVIEVWDLDivdSLEPVFTlgsklskkkkkkgkksssAEGHTDAVLDLSWNKLIRnVLASASADNTVI 282
Cdd:cd00200  61 ADGTYLASGSSDKTIRLWDLE---TGECVRT------------------LTGHTSYVSSVAFSPDGR-ILSSSSRDKTIK 118

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5902034  283 LWDMSLGKPAASLAVHTDKVQTLQFHPFEaQTLISGSYDKSVALYDcrsPDESHRMWRFSGQIERVTWNHFSP--CHFLA 360
Cdd:cd00200 119 VWDVETGKCLTTLRGHTDWVNSVAFSPDG-TFVASSSQDGTIKLWD---LRTGKCVATLTGHTGEVNSVAFSPdgEKLLS 194

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5902034  361 STDDGFVYNLDARSDKPIFTLNAHNDEISGLDLSSQiKGCLVTASADKYVKIWDILGDRPSLV---HSRDmkmgvLFCSS 437
Cdd:cd00200 195 SSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPD-GYLLASGSEDGTIRVWDLRTGECVQTlsgHTNS-----VTSLA 268

                       250       260
                ....*....|....*....|..
gi 5902034  438 CCPDLPFIYAfGGQKEGLRVWD 459
Cdd:cd00200 269 WSPDGKRLAS-GSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
184-415 2.09e-24

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 104.99  E-value: 2.09e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5902034  184 LSAYPLSVEWLNFdpSPDdstGNYIAVGNMTPVIEVWDldiVDSLEPVFTLgsklskkkkkkgkksssaEGHTDAVLDLS 263
Cdd:COG2319 200 LTGHTGAVRSVAF--SPD---GKLLASGSADGTVRLWD---LATGKLLRTL------------------TGHSGSVRSVA 253

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5902034  264 WN---KLirnvLASASADNTVILWDMSLGKPAASLAVHTDKVQTLQFHPfEAQTLISGSYDKSVALYDCRSPDESHRMWR 340
Cdd:COG2319 254 FSpdgRL----LASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSP-DGKLLASGSDDGTVRLWDLATGKLLRTLTG 328

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 5902034  341 FSGQIERVTwnhFSPC-HFLAS-TDDGFVYNLDARSDKPIFTLNAHNDEISGLDLSSQikGC-LVTASADKYVKIWDI 415
Cdd:COG2319 329 HTGAVRSVA---FSPDgKTLASgSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPD--GRtLASGSADGTVRLWDL 401
WD40 COG2319
WD40 repeat [General function prediction only];
252-462 6.43e-24

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 103.45  E-value: 6.43e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5902034  252 AEGHTDAVLDLSWNkLIRNVLASASADNTVILWDMSLGKPAASLAVHTDKVQTLQFHPfEAQTLISGSYDKSVALYDcrs 331
Cdd:COG2319  74 LLGHTAAVLSVAFS-PDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSP-DGKTLASGSADGTVRLWD--- 148

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5902034  332 PDESHRMWRFSGQIERVTWNHFSP-CHFLAST-DDGFVYNLDARSDKPIFTLNAHNDEISGLDLS--SQIkgcLVTASAD 407
Cdd:COG2319 149 LATGKLLRTLTGHSGAVTSVAFSPdGKLLASGsDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSpdGKL---LASGSAD 225

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 5902034  408 KYVKIWDILGDRP--SLVHSRDMKMGVLFcSsccPDLPFIyAFGGQKEGLRVWDIST 462
Cdd:COG2319 226 GTVRLWDLATGKLlrTLTGHSGSVRSVAF-S---PDGRLL-ASGSADGTVRLWDLAT 277
WD40 COG2319
WD40 repeat [General function prediction only];
252-462 3.50e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 86.50  E-value: 3.50e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5902034  252 AEGHTDAVLDLSWNkLIRNVLASASADNTVILWDMSLGKPAASLAVHTDKVQTLQFHPfEAQTLISGSYDKSVALYDCRS 331
Cdd:COG2319  32 LLGLAAAVASLAAS-PDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSP-DGRLLASASADGTVRLWDLAT 109

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5902034  332 PDESHRMWRFSGQIERVTwnhFSP-CHFLAST-DDGFVYNLDARSDKPIFTLNAHNDEISGLDLS--SQIkgcLVTASAD 407
Cdd:COG2319 110 GLLLRTLTGHTGAVRSVA---FSPdGKTLASGsADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSpdGKL---LASGSDD 183

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*
gi 5902034  408 KYVKIWDILGDRpsLVHSRDMKMGVLFCSSCCPDLPFIyAFGGQKEGLRVWDIST 462
Cdd:COG2319 184 GTVRLWDLATGK--LLRTLTGHTGAVRSVAFSPDGKLL-ASGSADGTVRLWDLAT 235
PTZ00420 PTZ00420
coronin; Provisional
 253-328 2.50e-06

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 49.95  E-value: 2.50e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5902034   253 EGHTDAVLDLSWNKLIRNVLASASADNTVILWDM--------SLGKPAASLAVHTDKVQTLQFHPFEAQTLISGSYDKSV 324
Cdd:PTZ00420  71 KGHTSSILDLQFNPCFSEILASGSEDLTIRVWEIphndesvkEIKDPQCILKGHKKKISIIDWNPMNYYIMCSSGFDSFV 150


                 ....
gi 5902034   325 ALYD 328
Cdd:PTZ00420 151 NIWD 154
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 262-415 2.66e-06

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 50.09  E-value: 2.66e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5902034   262 LSWNKLIRNVLASASADNTVILWDMSLGKPAASLAVHTDKVQTLQFHPFEAQTLISGSYDKSVALYDCRS---------- 331
Cdd:PLN00181 538 ICWNSYIKSQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLLASGSDDGSVKLWSINQgvsigtiktk 617

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5902034   332 --------PDESHRMWRFsgqiervtwnhfspchflaSTDDGFVYNLDARSDK-PIFTLNAHNDEISGLDLSSQikGCLV 402
Cdd:PLN00181 618 aniccvqfPSESGRSLAF-------------------GSADHKVYYYDLRNPKlPLCTMIGHSKTVSYVRFVDS--STLV 676

                        170
                 ....*....|...
gi 5902034   403 TASADKYVKIWDI 415
Cdd:PLN00181 677 SSSTDNTLKLWDL 689
PTZ00421 PTZ00421
coronin; Provisional
 253-350 3.05e-06

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 49.51  E-value: 3.05e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5902034   253 EGHTDAVLDLSWNKLIRNVLASASADNTVILWDMSLGKPAASLAVHTDKVQTLQFHpFEAQTLISGSYDKSVALYDCRSP 332
Cdd:PTZ00421 122 QGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVERGKAVEVIKCHSDQITSLEWN-LDGSLLCTTSKDKKLNIIDPRDG 200

                         90       100
                 ....*....|....*....|...
gi 5902034   333 D-----ESHRmwrfSGQIERVTW 350
Cdd:PTZ00421 201 TivssvEAHA----SAKSQRCLW 219
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 374-414 2.55e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.14  E-value: 2.55e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 5902034     374 SDKPIFTLNAHNDEISGLDLSSQIKgCLVTASADKYVKIWD 414
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGK-YLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 253-285 5.60e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.37  E-value: 5.60e-05
                           10        20        30
                   ....*....|....*....|....*....|...
gi 5902034     253 EGHTDAVLDLSWNKLiRNVLASASADNTVILWD 285
Cdd:smart00320   9 KGHTGPVTSVAFSPD-GKYLASGSDDGTIKLWD 40
PTZ00421 PTZ00421
coronin; Provisional
 254-454 1.39e-04

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 44.50  E-value: 1.39e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5902034   254 GHTDAVLDLSWNKLIRNVLASASADNTVILWDM-------SLGKPAASLAVHTDKVQTLQFHPFEAQTLISGSYDKSVAL 326
Cdd:PTZ00421  73 GQEGPIIDVAFNPFDPQKLFTASEDGTIMGWGIpeegltqNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNV 152

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5902034   327 YDCRSPDESHRMWRFSGQIERVTWNhFSPCHFLASTDDGFVYNLDARSDKPIFTLNAHNDEISGLDLSSQIKGCLVTASA 406
Cdd:PTZ00421 153 WDVERGKAVEVIKCHSDQITSLEWN-LDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHASAKSQRCLWAKRKDLIITLGC 231

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 5902034   407 DK----YVKIWDILgDRPSLVHSRDMKmgvlfcSSCCPDLPF------IYAFGGQKEG 454
Cdd:PTZ00421 232 SKsqqrQIMLWDTR-KMASPYSTVDLD------QSSALFIPFfdedtnLLYIGSKGEG 282
WD40 pfam00400
WD domain, G-beta repeat;
376-414 4.53e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.71  E-value: 4.53e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 5902034    376 KPIFTLNAHNDEISGLDLSSQiKGCLVTASADKYVKIWD 414
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPD-GKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
253-285 5.51e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.71  E-value: 5.51e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 5902034    253 EGHTDAVLDLSWNKLiRNVLASASADNTVILWD 285
Cdd:pfam00400   8 EGHTGSVTSLAFSPD-GKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 289-328 6.95e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.29  E-value: 6.95e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 5902034     289 GKPAASLAVHTDKVQTLQFHPFEaQTLISGSYDKSVALYD 328
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDG-KYLASGSDDGTIKLWD 40
WD40 COG2319
WD40 repeat [General function prediction only];
199-287 8.43e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 41.82  E-value: 8.43e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5902034  199 SPDdstGNYIAVGNMTPVIEVWDLDivdSLEPVFTLgsklskkkkkkgkksssaEGHTDAVLDLSWN---KLirnvLASA 275
Cdd:COG2319 339 SPD---GKTLASGSDDGTVRLWDLA---TGELLRTL------------------TGHTGAVTSVAFSpdgRT----LASG 390

                        90
                ....*....|..
gi 5902034  276 SADNTVILWDMS 287
Cdd:COG2319 391 SADGTVRLWDLA 402
WD40 pfam00400
WD domain, G-beta repeat;
289-328 4.32e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.01  E-value: 4.32e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 5902034    289 GKPAASLAVHTDKVQTLQFHPfEAQTLISGSYDKSVALYD 328
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSP-DGKLLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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