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Conserved domains on  [gi|6319631|ref|NP_009713|]
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HSP70/90 family co-chaperone CNS1 [Saccharomyces cerevisiae S288C]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CTWD_TTC4 cd21381
C-terminal wheel domain found in Homo sapiens tetratricopeptide repeat protein 4 (TTC4) and ...
 221-374 2.71e-70

C-terminal wheel domain found in Homo sapiens tetratricopeptide repeat protein 4 (TTC4) and similar proteins; TTC4, also called TPR repeat protein 4, is a putative Hsp90 co-chaperone which interacts with CDC6 and shows alterations in transformed cells. It interacts with TBK1 and promotes Sendai virus (SeV)-induced host cell innate immune responses. The model corresponds to TTC4 C-terminal wheel domain consisting of a twisted five-stranded beta sheet surrounded by several alpha helices.


:

Pssm-ID: 439175  Cd Length: 150  Bit Score: 217.38  E-value: 2.71e-70
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319631  221 ENKKIMLESAMTLRNITNIKTHSPVELLNEGKIRLEDPMDFESQLIYPALIMYPTQDEFDFVGEVSELTTVQELVDLVLE 300
Cdd:cd21381   2 ERKKKTLKAALKARNITTRTTSQPPELLEDAKILLEDPLDPESQLIFPALLLYPLHLQSDFIKAFSELSTPQEHLEYVLP 81

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 6319631  301 GPQERfkkEGKENFTPKKVLVFMETKAGGLIKAGKKLTFHDILKKESpdVPLFDNALKIYIVPKVESEGWISKW 374
Cdd:cd21381  82 RPWDW---DKHEEYTPKNVECYMETESGGLVKVGKKVPLLKVLSNGK--VPLFDGLLRIYVVPKNKAAEWIKEW 150
3a0801s09 super family cl36792
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ...
 68-218 7.96e-13

mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]


The actual alignment was detected with superfamily member TIGR00990:

Pssm-ID: 273380 [Multi-domain]  Cd Length: 615  Bit Score: 69.63  E-value: 7.96e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319631     68 EALKALAYEGEPHEIAENFKKQGNELYKAKRFKDARELYSKglAVECEDKSInesLYANRAACELELKNYRRCIEDCSKA 147
Cdd:TIGR00990 112 ESSVANLSEEERKKYAAKLKEKGNKAYRNKDFNKAIKLYSK--AIECKPDPV---YYSNRAACHNALGDWEKVVEDTTAA 186

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 6319631    148 LTINPKNVKCYYRTSKAFFQLNKLEEAKSAATFANQRIDPENKSILNMLSVIDRKEQELKAKEEKQQREAQ 218
Cdd:TIGR00990 187 LELDPDYSKALNRRANAYDGLGKYADALLDLTASCIIDGFRNEQSAQAVERLLKKFAESKAKEILETKPEN 257
 
Name Accession Description Interval E-value
CTWD_TTC4 cd21381
C-terminal wheel domain found in Homo sapiens tetratricopeptide repeat protein 4 (TTC4) and ...
 221-374 2.71e-70

C-terminal wheel domain found in Homo sapiens tetratricopeptide repeat protein 4 (TTC4) and similar proteins; TTC4, also called TPR repeat protein 4, is a putative Hsp90 co-chaperone which interacts with CDC6 and shows alterations in transformed cells. It interacts with TBK1 and promotes Sendai virus (SeV)-induced host cell innate immune responses. The model corresponds to TTC4 C-terminal wheel domain consisting of a twisted five-stranded beta sheet surrounded by several alpha helices.


Pssm-ID: 439175  Cd Length: 150  Bit Score: 217.38  E-value: 2.71e-70
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319631  221 ENKKIMLESAMTLRNITNIKTHSPVELLNEGKIRLEDPMDFESQLIYPALIMYPTQDEFDFVGEVSELTTVQELVDLVLE 300
Cdd:cd21381   2 ERKKKTLKAALKARNITTRTTSQPPELLEDAKILLEDPLDPESQLIFPALLLYPLHLQSDFIKAFSELSTPQEHLEYVLP 81

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 6319631  301 GPQERfkkEGKENFTPKKVLVFMETKAGGLIKAGKKLTFHDILKKESpdVPLFDNALKIYIVPKVESEGWISKW 374
Cdd:cd21381  82 RPWDW---DKHEEYTPKNVECYMETESGGLVKVGKKVPLLKVLSNGK--VPLFDGLLRIYVVPKNKAAEWIKEW 150
Wheel pfam18972
Cns1/TTC4 Wheel domain; The wheel domain is found at the C-terminus of yeast Cns1 and human ...
 257-374 1.31e-40

Cns1/TTC4 Wheel domain; The wheel domain is found at the C-terminus of yeast Cns1 and human TTC4 proteins. The structure of the domain shows an overall fold consisting of a twisted five-stranded beta sheet surrounded by several alpha helices. The Hsp90 chaperone machinery in eukaryotes comprises a number of distinct accessory factors. Cns1 is one of the few essential co-chaperones in yeast. Cns1 is important for maintaining translation elongation, specifically chaperoning the elongation factor eEF2. In this context, Cns1 interacts with the novel co-factor Hgh1 and forms a quaternary complex together with eEF2 and Hsp90.


Pssm-ID: 436877  Cd Length: 114  Bit Score: 139.28  E-value: 1.31e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319631    257 DPMDFESQLIYPALIMYPTQDEFDFVGEVSELTTVQELVDLVLEGPQERfkkEGKENFTPKKVLVFMETKAGGLIKAGKK 336
Cdd:pfam18972   1 DPDDPESTLIFPVFFLYPLHAQSDFIKAFSETTTPQDHLEYVFPSPPPW---DTKKEYTPKNVEVYMETRTGGLVKVGKK 77

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 6319631    337 LTFHDILKKEsPDVPLFDNALKIYIVPKVESEGWISKW 374
Cdd:pfam18972  78 VPLRKVLSSA-PKVELVDGLLRIYVVPKGKAQKWIEDW 114
3a0801s09 TIGR00990
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ...
 68-218 7.96e-13

mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273380 [Multi-domain]  Cd Length: 615  Bit Score: 69.63  E-value: 7.96e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319631     68 EALKALAYEGEPHEIAENFKKQGNELYKAKRFKDARELYSKglAVECEDKSInesLYANRAACELELKNYRRCIEDCSKA 147
Cdd:TIGR00990 112 ESSVANLSEEERKKYAAKLKEKGNKAYRNKDFNKAIKLYSK--AIECKPDPV---YYSNRAACHNALGDWEKVVEDTTAA 186

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 6319631    148 LTINPKNVKCYYRTSKAFFQLNKLEEAKSAATFANQRIDPENKSILNMLSVIDRKEQELKAKEEKQQREAQ 218
Cdd:TIGR00990 187 LELDPDYSKALNRRANAYDGLGKYADALLDLTASCIIDGFRNEQSAQAVERLLKKFAESKAKEILETKPEN 257
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
68-222 1.22e-11

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 64.26  E-value: 1.22e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319631   68 EALKAL--AYEGEPHEiAENFKKQGNELYKAKRFKDARELYSKGLAVECEDKSIneslYANRAACELELKNYRRCIEDCS 145
Cdd:COG0457  26 EAIEDYekALELDPDD-AEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEA----LNNLGLALQALGRYEEALEDYD 100

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 6319631  146 KALTINPKNVKCYYRTSKAFFQLNKLEEAKSAATFAnQRIDPENKSILNMLSVIDRKEQELKAKEEKQQREAQEREN 222
Cdd:COG0457 101 KALELDPDDAEALYNLGLALLELGRYDEAIEAYERA-LELDPDDADALYNLGIALEKLGRYEEALELLEKLEAAALA 176
PLN03088 PLN03088
SGT1, suppressor of G2 allele of SKP1; Provisional
 99-211 9.21e-06

SGT1, suppressor of G2 allele of SKP1; Provisional


Pssm-ID: 215568 [Multi-domain]  Cd Length: 356  Bit Score: 47.09  E-value: 9.21e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319631    99 FKDARELYSKGLAVEcedkSINESLYANRAACELELKNYRRCIEDCSKALTINPKNVKCYYRTSKAFFQLNKLEEAKsAA 178
Cdd:PLN03088  18 FALAVDLYTQAIDLD----PNNAELYADRAQANIKLGNFTEAVADANKAIELDPSLAKAYLRKGTACMKLEEYQTAK-AA 92

                         90       100       110
                 ....*....|....*....|....*....|...
gi 6319631   179 TFANQRIDPENKSILNMLsvidrKEQELKAKEE 211
Cdd:PLN03088  93 LEKGASLAPGDSRFTKLI-----KECDEKIAEE 120
TPR_1 pfam00515
Tetratricopeptide repeat;
124-154 9.59e-05

Tetratricopeptide repeat;


Pssm-ID: 459840 [Multi-domain]  Cd Length: 34  Bit Score: 39.33  E-value: 9.59e-05
                          10        20        30
                  ....*....|....*....|....*....|.
gi 6319631    124 YANRAACELELKNYRRCIEDCSKALTINPKN 154
Cdd:pfam00515   4 LYNLGNAYFKLGKYDEALEYYEKALELNPNN 34
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 124-154 2.75e-04

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 37.81  E-value: 2.75e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 6319631     124 YANRAACELELKNYRRCIEDCSKALTINPKN 154
Cdd:smart00028   4 LYNLGNAYLKLGDYDEALEYYEKALELDPNN 34
 
Name Accession Description Interval E-value
CTWD_TTC4 cd21381
C-terminal wheel domain found in Homo sapiens tetratricopeptide repeat protein 4 (TTC4) and ...
 221-374 2.71e-70

C-terminal wheel domain found in Homo sapiens tetratricopeptide repeat protein 4 (TTC4) and similar proteins; TTC4, also called TPR repeat protein 4, is a putative Hsp90 co-chaperone which interacts with CDC6 and shows alterations in transformed cells. It interacts with TBK1 and promotes Sendai virus (SeV)-induced host cell innate immune responses. The model corresponds to TTC4 C-terminal wheel domain consisting of a twisted five-stranded beta sheet surrounded by several alpha helices.


Pssm-ID: 439175  Cd Length: 150  Bit Score: 217.38  E-value: 2.71e-70
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319631  221 ENKKIMLESAMTLRNITNIKTHSPVELLNEGKIRLEDPMDFESQLIYPALIMYPTQDEFDFVGEVSELTTVQELVDLVLE 300
Cdd:cd21381   2 ERKKKTLKAALKARNITTRTTSQPPELLEDAKILLEDPLDPESQLIFPALLLYPLHLQSDFIKAFSELSTPQEHLEYVLP 81

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 6319631  301 GPQERfkkEGKENFTPKKVLVFMETKAGGLIKAGKKLTFHDILKKESpdVPLFDNALKIYIVPKVESEGWISKW 374
Cdd:cd21381  82 RPWDW---DKHEEYTPKNVECYMETESGGLVKVGKKVPLLKVLSNGK--VPLFDGLLRIYVVPKNKAAEWIKEW 150
Wheel pfam18972
Cns1/TTC4 Wheel domain; The wheel domain is found at the C-terminus of yeast Cns1 and human ...
 257-374 1.31e-40

Cns1/TTC4 Wheel domain; The wheel domain is found at the C-terminus of yeast Cns1 and human TTC4 proteins. The structure of the domain shows an overall fold consisting of a twisted five-stranded beta sheet surrounded by several alpha helices. The Hsp90 chaperone machinery in eukaryotes comprises a number of distinct accessory factors. Cns1 is one of the few essential co-chaperones in yeast. Cns1 is important for maintaining translation elongation, specifically chaperoning the elongation factor eEF2. In this context, Cns1 interacts with the novel co-factor Hgh1 and forms a quaternary complex together with eEF2 and Hsp90.


Pssm-ID: 436877  Cd Length: 114  Bit Score: 139.28  E-value: 1.31e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319631    257 DPMDFESQLIYPALIMYPTQDEFDFVGEVSELTTVQELVDLVLEGPQERfkkEGKENFTPKKVLVFMETKAGGLIKAGKK 336
Cdd:pfam18972   1 DPDDPESTLIFPVFFLYPLHAQSDFIKAFSETTTPQDHLEYVFPSPPPW---DTKKEYTPKNVEVYMETRTGGLVKVGKK 77

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 6319631    337 LTFHDILKKEsPDVPLFDNALKIYIVPKVESEGWISKW 374
Cdd:pfam18972  78 VPLRKVLSSA-PKVELVDGLLRIYVVPKGKAQKWIEDW 114
CTWD_Cns1-like cd21377
C-terminal wheel domain found in Saccharomyces cerevisiae Hsp70/Hsp90 co-chaperone Cns1, Homo ...
 226-364 2.58e-20

C-terminal wheel domain found in Saccharomyces cerevisiae Hsp70/Hsp90 co-chaperone Cns1, Homo sapiens tetratricopeptide repeat protein 4 (TTC4), and similar proteins; The family includes Hsp70/Hsp90 co-chaperone Cns1 from Saccharomyces cerevisiae and the human Cns1 homolog tetratricopeptide repeat protein 4 (TTC4), both of which contain a C-terminal wheel domain consisting of a twisted five-stranded beta sheet surrounded by several alpha helices. Cns1, also called cyclophilin seven suppressor 1, or STI1 stress-inducible protein homolog, binds to the molecular chaperones Hsp90 (HSC82 and HSP82) and Hsp70 (SSA1). It stimulates SSA1 ATPase activity, but not Hsp90 ATPase activity. It is involved in only a subset of Hsp90 functions. TTC4, also called TPR repeat protein 4, is a putative Hsp90 co-chaperone which interacts with CDC6 and shows alterations in transformed cells. It interacts with TBK1 and promotes Sendai virus (SeV)-induced host cell innate immune responses.


Pssm-ID: 439173  Cd Length: 159  Bit Score: 86.62  E-value: 2.58e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319631  226 MLESAMTLRNITNIKTHSPVELLNEGKIRLEDpmdfESQLIYPALIMYPTQDEFDFVGEVSELTTVQELVDLVLEGPQER 305
Cdd:cd21377   2 ALLSALKSRGIKLGPPLYDEELTGERKPYLDE----DGELHWPVLLLYPEVGQSDFIEDFSEDDTLGDHLDVMFPEPAPP 77

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 6319631  306 FKKEGKENFTPKKVLVFMET---------------KAGGLIKAGKKLTFHDILKkeSPDVPLFDNALKIYIVPK 364
Cdd:cd21377  78 LPWDTEGEYTRDNLEVYYETnavkplpsesskagpKEKKWVRVDPDTTLGDVLA--HPDYYVIPGIPVFYVVPK 149
3a0801s09 TIGR00990
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ...
 68-218 7.96e-13

mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273380 [Multi-domain]  Cd Length: 615  Bit Score: 69.63  E-value: 7.96e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319631     68 EALKALAYEGEPHEIAENFKKQGNELYKAKRFKDARELYSKglAVECEDKSInesLYANRAACELELKNYRRCIEDCSKA 147
Cdd:TIGR00990 112 ESSVANLSEEERKKYAAKLKEKGNKAYRNKDFNKAIKLYSK--AIECKPDPV---YYSNRAACHNALGDWEKVVEDTTAA 186

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 6319631    148 LTINPKNVKCYYRTSKAFFQLNKLEEAKSAATFANQRIDPENKSILNMLSVIDRKEQELKAKEEKQQREAQ 218
Cdd:TIGR00990 187 LELDPDYSKALNRRANAYDGLGKYADALLDLTASCIIDGFRNEQSAQAVERLLKKFAESKAKEILETKPEN 257
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
68-222 1.22e-11

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 64.26  E-value: 1.22e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319631   68 EALKAL--AYEGEPHEiAENFKKQGNELYKAKRFKDARELYSKGLAVECEDKSIneslYANRAACELELKNYRRCIEDCS 145
Cdd:COG0457  26 EAIEDYekALELDPDD-AEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEA----LNNLGLALQALGRYEEALEDYD 100

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 6319631  146 KALTINPKNVKCYYRTSKAFFQLNKLEEAKSAATFAnQRIDPENKSILNMLSVIDRKEQELKAKEEKQQREAQEREN 222
Cdd:COG0457 101 KALELDPDDAEALYNLGLALLELGRYDEAIEAYERA-LELDPDDADALYNLGIALEKLGRYEEALELLEKLEAAALA 176
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
90-207 1.88e-09

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 57.71  E-value: 1.88e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319631   90 GNELYKAKRFKDARELYSKGLAVEcedkSINESLYANRAACELELKNYRRCIEDCSKALTINPKNVKCYYRTSKAFFQLN 169
Cdd:COG0457  15 GLAYRRLGRYEEAIEDYEKALELD----PDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLALQALG 90

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 6319631  170 KLEEAKSAATFAnQRIDPENKSILNMLSVIDRKEQELK 207
Cdd:COG0457  91 RYEEALEDYDKA-LELDPDDAEALYNLGLALLELGRYD 127
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
68-221 7.44e-09

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 55.78  E-value: 7.44e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319631   68 EALKAL--AYEGEPhEIAENFKKQGNELYKAKRFKDARELYSKGLAVECEDKSIneslYANRAACELELKNYRRCIEDCS 145
Cdd:COG0457  60 EALADYeqALELDP-DDAEALNNLGLALQALGRYEEALEDYDKALELDPDDAEA----LYNLGLALLELGRYDEAIEAYE 134

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 6319631  146 KALTINPKNVKCYYRTSKAFFQLNKLEEAKSAATFANQRIDPENKSILNMLSVIDRKEQELKAKEEKQQREAQERE 221
Cdd:COG0457 135 RALELDPDDADALYNLGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQALRKK 210
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 67-196 1.70e-07

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 53.07  E-value: 1.70e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319631   67 LEALKALAYEGEPHEIAENFKKQGNELYKAKRFKDARELYSKGLAVecedKSINESLYANRAACELELKNYRRCIEDCSK 146
Cdd:COG3914  62 LAAGEAAAAAAALLLLAALLELAALLLQALGRYEEALALYRRALAL----NPDNAEALFNLGNLLLALGRLEEALAALRR 137

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 6319631  147 ALTINPKNVKCYYRTSKAFFQLNKLEEAKSAATFANqRIDPENKSILNML 196
Cdd:COG3914 138 ALALNPDFAEAYLNLGEALRRLGRLEEAIAALRRAL-ELDPDNAEALNNL 186
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 90-227 5.78e-07

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 50.50  E-value: 5.78e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319631   90 GNELYKAKRFKDARELYSKGLAVECEdksiNESLYANRAACELELKNYRRCIEDCSKALTINPKNVKCYYRTSKAFFQLN 169
Cdd:COG2956  83 AQDYLKAGLLDRAEELLEKLLELDPD----DAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHAYCELAELYLEQG 158

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 6319631  170 KLEEAKSAATFANQrIDPENKSILNMLSVIDRKEQEL-KAKEEKQQREAQERENKKIML 227
Cdd:COG2956 159 DYDEAIEALEKALK-LDPDCARALLLLAELYLEQGDYeEAIAALERALEQDPDYLPALP 216
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 54-177 4.11e-06

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 46.49  E-value: 4.11e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319631   54 LDETDGAGGENVELEALKALAYEGEPHEIAENFKKQGNELYKAKRFKDARELYSKGLAVECEdksiNESLYANRAACELE 133
Cdd:COG5010  25 EKYEAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQLDPN----NPELYYNLALLYSR 100

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 6319631  134 LKNYRRCIEDCSKALTINPKNVKCYYRTSKAFFQLNKLEEAKSA 177
Cdd:COG5010 101 SGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQDDEAKAA 144
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
124-215 8.48e-06

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 46.54  E-value: 8.48e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319631  124 YANRAACELELKNYRRCIEDCSKALTINPKNVKCYYRTSKAFFQLNKLEEAKSAATFAnQRIDPENKSILNMLSVIDRKE 203
Cdd:COG0457  11 YNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQA-LELDPDDAEALNNLGLALQAL 89

                        90
                ....*....|..
gi 6319631  204 QELKAKEEKQQR 215
Cdd:COG0457  90 GRYEEALEDYDK 101
CTWD_Cns1 cd21380
C-terminal wheel domain found in Saccharomyces cerevisiae Hsp70/Hsp90 co-chaperone Cns1 and ...
 226-364 9.12e-06

C-terminal wheel domain found in Saccharomyces cerevisiae Hsp70/Hsp90 co-chaperone Cns1 and similar proteins; Cns1, also called cyclophilin seven suppressor 1, or STI1 stress-inducible protein homolog, binds to the molecular chaperones Hsp90 (HSC82 and HSP82) and Hsp70 (SSA1). It stimulates SSA1 ATPase activity, but not Hsp90 ATPase activity. It is involved in only a subset of Hsp90 functions. The model corresponds to Cns1 C-terminal wheel domain consisting of a twisted five-stranded beta sheet surrounded by several alpha helices.


Pssm-ID: 439174  Cd Length: 153  Bit Score: 45.24  E-value: 9.12e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319631  226 MLESAMTLRNItNIKTHSPVELLNEGKIRLEDP--------MDFESQLIYPALIMYPtqdEF---DFVGEVSELTTVQEL 294
Cdd:cd21380   2 KLIKAIKERGI-KLEGSKKGESDDLSLLEPCHPelsgarvhLDEEGRLVWPVLFLYP---EYkqsDFIQAFHEDTTFIDH 77

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 6319631  295 VDLVLEGPQErFKKEGKenFTPKKVLVFMETKAGG-LIKAGKKLTFHDILKkeSPDVPLFDNALKIYIVPK 364
Cdd:cd21380  78 LEVMFEEPPP-WDVEKK--YTPDNLNVYFEDRDKGkLVKVDPKSTLGEVLS--HKRYVVKNGTPSFIVLVK 143
PLN03088 PLN03088
SGT1, suppressor of G2 allele of SKP1; Provisional
 99-211 9.21e-06

SGT1, suppressor of G2 allele of SKP1; Provisional


Pssm-ID: 215568 [Multi-domain]  Cd Length: 356  Bit Score: 47.09  E-value: 9.21e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319631    99 FKDARELYSKGLAVEcedkSINESLYANRAACELELKNYRRCIEDCSKALTINPKNVKCYYRTSKAFFQLNKLEEAKsAA 178
Cdd:PLN03088  18 FALAVDLYTQAIDLD----PNNAELYADRAQANIKLGNFTEAVADANKAIELDPSLAKAYLRKGTACMKLEEYQTAK-AA 92

                         90       100       110
                 ....*....|....*....|....*....|...
gi 6319631   179 TFANQRIDPENKSILNMLsvidrKEQELKAKEE 211
Cdd:PLN03088  93 LEKGASLAPGDSRFTKLI-----KECDEKIAEE 120
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
81-214 1.05e-05

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 46.06  E-value: 1.05e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319631   81 EIAENFKKQGNELYKAKRFKDARELYSKGLAVECEdksiNESLYANRAACELELKNYRRCIEDCSKALTINPKNVKCYYR 160
Cdd:COG4785  71 DLAQLYYERGVAYDSLGDYDLAIADFDQALELDPD----LAEAYNNRGLAYLLLGDYDAALEDFDRALELDPDYAYAYLN 146

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 6319631  161 TSKAFFQLNKLEEAksAATFAN-QRIDPENKSILNMLSVIDRKEQELKAKEEKQQ 214
Cdd:COG4785 147 RGIALYYLGRYELA--IADLEKaLELDPNDPERALWLYLAERKLDPEKALALLLE 199
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
66-189 2.77e-05

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 44.91  E-value: 2.77e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319631   66 ELEALKALAYEGEPHEIAENFKKQGNELYKAKRFKDARELYSKGLAVEcEDKSINESLYANRAACELELKNYRRCIEDCS 145
Cdd:COG4785  19 ASKAAILLAALLFAAVLALAIALADLALALAAAALAAAALAAERIDRA-LALPDLAQLYYERGVAYDSLGDYDLAIADFD 97

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 6319631  146 KALTINPKNVKCYYRTSKAFFQLNKLEEAKSAATFAnQRIDPEN 189
Cdd:COG4785  98 QALELDPDLAEAYNNRGLAYLLLGDYDAALEDFDRA-LELDPDY 140
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 83-177 3.79e-05

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 43.07  E-value: 3.79e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319631   83 AENFKKQGNELYKAKRFKDARELYSKGLAVECEdksiNESLYANRAACELELKNYRRCIEDCSKALTINPKNVKCYYRTS 162
Cdd:COG4235  17 AEGWLLLGRAYLRLGRYDEALAAYEKALRLDPD----NADALLDLAEALLAAGDTEEAEELLERALALDPDNPEALYLLG 92

                        90
                ....*....|....*
gi 6319631  163 KAFFQLNKLEEAKSA 177
Cdd:COG4235  93 LAAFQQGDYAEAIAA 107
TPR_1 pfam00515
Tetratricopeptide repeat;
124-154 9.59e-05

Tetratricopeptide repeat;


Pssm-ID: 459840 [Multi-domain]  Cd Length: 34  Bit Score: 39.33  E-value: 9.59e-05
                          10        20        30
                  ....*....|....*....|....*....|.
gi 6319631    124 YANRAACELELKNYRRCIEDCSKALTINPKN 154
Cdd:pfam00515   4 LYNLGNAYFKLGKYDEALEYYEKALELNPNN 34
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 68-210 1.02e-04

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 43.56  E-value: 1.02e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319631   68 EALKALAY----EGEPHEIAENFKK--------------QGNELYKAKRFKDARELYSKGLAVeceDKSiNESLYANRAA 129
Cdd:COG2956 111 EALRLLAEiyeqEGDWEKAIEVLERllklgpenahayceLAELYLEQGDYDEAIEALEKALKL---DPD-CARALLLLAE 186

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319631  130 CELELKNYRRCIEDCSKALTINPKNVKCYYRTSKAFFQLNKLEEAKSAATFANQRiDPENKSILNMLSVIDRKEQELKAK 209
Cdd:COG2956 187 LYLEQGDYEEAIAALERALEQDPDYLPALPRLAELYEKLGDPEEALELLRKALEL-DPSDDLLLALADLLERKEGLEAAL 265


                .
gi 6319631  210 E 210
Cdd:COG2956 266 A 266
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 71-222 2.37e-04

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 43.06  E-value: 2.37e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319631   71 KALAYEGEPHEIAENFkkqGNELYKAKRFKDARELYSKGLAVECEdksiNESLYANRAACELELKNYRRCIEDCSKALTI 150
Cdd:COG3914 103 RALALNPDNAEALFNL---GNLLLALGRLEEALAALRRALALNPD----FAEAYLNLGEALRRLGRLEEAIAALRRALEL 175

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6319631  151 NPKNVKCYYRTSKAFFQLNKLEEAKSAATFANQrIDPENKSILNMLSVIDRKEQELKAKEEKQQREAQEREN 222
Cdd:COG3914 176 DPDNAEALNNLGNALQDLGRLEEAIAAYRRALE-LDPDNADAHSNLLFALRQACDWEVYDRFEELLAALARG 246
LcrH_SycD TIGR02552
type III secretion low calcium response chaperone LcrH/SycD; Genes in this family are found in ...
 66-189 2.48e-04

type III secretion low calcium response chaperone LcrH/SycD; Genes in this family are found in type III secretion operons. LcrH, from Yersinia is believed to have a regulatory function in the low-calcium response of the secretion system. The same protein is also known as SycD (SYC = Specific Yop Chaperone) for its chaperone role. In Pseudomonas, where the homolog is known as PcrH, the chaperone role has been demonstrated and the regulatory role appears to be absent. ScyD/LcrH contains three central tetratricopeptide-like repeats that are predicted to fold into an all-alpha-helical array.


Pssm-ID: 274197 [Multi-domain]  Cd Length: 135  Bit Score: 40.74  E-value: 2.48e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319631     66 ELEALKALAYEgepheiaenfkkqgneLYKAKRFKDARELYSkGLAVeCEdksINESLYANR-AACELELKNYRRCIEDC 144
Cdd:TIGR02552  16 QLEQIYALAYN----------------LYQQGRYDEALKLFQ-LLAA-YD---PYNSRYWLGlAACCQMLKEYEEAIDAY 74

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 6319631    145 SKALTINPKNVKCYYRTSKAFFQLNKLEEAKsAATFANQRIDPEN 189
Cdd:TIGR02552  75 ALAAALDPDDPRPYFHAAECLLALGEPESAL-KALDLAIEICGEN 118
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 124-154 2.75e-04

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 37.81  E-value: 2.75e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 6319631     124 YANRAACELELKNYRRCIEDCSKALTINPKN 154
Cdd:smart00028   4 LYNLGNAYLKLGDYDEALEYYEKALELDPNN 34
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 68-189 3.75e-04

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 40.18  E-value: 3.75e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319631   68 EALKAL--AYEGEPHEiAENFKKQGNELYKAKRFKDARELYSKGLAVECEdksiNESLYANRAACELELKNYRRCIEDCS 145
Cdd:COG4783  22 EAEALLekALELDPDN-PEAFALLGEILLQLGDLDEAIVLLHEALELDPD----EPEARLNLGLALLKAGDYDEALALLE 96

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 6319631  146 KALTINPKNVKCYYRTSKAFFQLNKLEEAKSAATFAnQRIDPEN 189
Cdd:COG4783  97 KALKLDPEHPEAYLRLARAYRALGRPDEAIAALEKA-LELDPDD 139
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
132-215 1.31e-03

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 37.84  E-value: 1.31e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319631  132 LELKNYRRCIEDCSKALTINPKNVKCYYRTSKAFFQLNKLEEAKSAAtfANQRIDPENKSILNMLSVIDRKEQELKAKEE 211
Cdd:COG3063   3 LKLGDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEAIALE--KALKLDPNNAEALLNLAELLLELGDYDEALA 80


                ....
gi 6319631  212 KQQR 215
Cdd:COG3063  81 YLER 84
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 92-177 1.94e-03

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 37.66  E-value: 1.94e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319631   92 ELYKAKRFKDARELYSKGLAVECEDKSINESLYaNRAACELELKNYRRCIEDCSKALTINPKNVK---CYYRTSKAFFQL 168
Cdd:COG1729   2 ALLKAGDYDEAIAAFKAFLKRYPNSPLAPDALY-WLGEAYYALGDYDEAAEAFEKLLKRYPDSPKapdALLKLGLSYLEL 80


                ....*....
gi 6319631  169 NKLEEAKSA 177
Cdd:COG1729  81 GDYDKARAT 89
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 120-222 7.11e-03

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 36.52  E-value: 7.11e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319631  120 NESLYANRAACELELKNYRRCIEDCSKALTINPKNVKCYYRTSKAFFQLNKLEEAKSAATFAnQRIDPENKSILNMLSVI 199
Cdd:COG4235  16 DAEGWLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERA-LALDPDNPEALYLLGLA 94

                        90       100
                ....*....|....*....|....
gi 6319631  200 DRKEQEL-KAKEEKQQREAQEREN 222
Cdd:COG4235  95 AFQQGDYaEAIAAWQKLLALLPAD 118
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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