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Conserved domains on  [gi|10383787|ref|NP_009952|]
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uncharacterized protein YCR023C [Saccharomyces cerevisiae S288C]

Protein Classification

MFS transporter( domain architecture ID 13023689)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085|GO:0016020
PubMed:  26758938|26098515|26234418
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 23-564 1.85e-68

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 225.92  E-value: 1.85e-68
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10383787  23 VSLVRFSEPIAFSSLFPYVYFMVRDFNiapNDAQVSKYSGYLSSSFALCQVISAYHWGRFSEKHGRKITLTCGLIGTSVS 102
Cdd:cd17330   1 LFLVVFLDALGFGIVFPVLPFYVREFN---KLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVS 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10383787 103 LLILGFSRNFYQALVARSLMGLLNGNVGVIRTIIGEIATERKhQALAFSTMPLLFQFGAVVGPMIGGFLVfrdgtmnevp 182
Cdd:cd17330  78 YVLLGLSRNLWLLFLARFLDGLTGGNVSVAQAYIADITDEEE-RAKAFGIISAAFGLGFILGPALGGFLS---------- 146

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10383787 183 lwfphfakriiRSYPYALPNVVVCMFLMFGLTNATLFLeethpafkdrrdyglevgdfikknifgiqpkrrpwqkriqdd 262
Cdd:cd17330 147 -----------TPYGYALPFLVAAALALLNLVLVLFFL------------------------------------------ 173

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10383787 263 senihhrnenvnsirgqdseedensplvnttndddtesiqsidpiltrrqsvglirtyslheptdavhanidtapdgcke 342
Cdd:cd17330     --------------------------------------------------------------------------------

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10383787 343 ssifhhvfhTKVFYPISVNFIMALHLIVYNEFLPVFLAYDLavdpenpkklaskfpwkisggiGYEPEQTGTLLSTTGIF 422
Cdd:cd17330 174 ---------PPLRRLLLVYFLIALAFAGLESVFSLFLKDRF----------------------GFSPSQIGLLLALVGIA 222

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10383787 423 GCFVVIFIFPIVDRNFDCLTIFRTLVKLYPIMYVMVPYVVFLQneripswytvvYLYIITGIKTFCGALTSPQIMLLIHN 502
Cdd:cd17330 223 GILAQLLLIPRLAKRLGERKLLRLGLLLAIIGLLLLPFASSVP-----------LLVLAAAILAFGTGIVFPALSALLSK 291

                       490       500       510       520       530       540
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 10383787 503 SSPLSCRSVINGATISISASARFIGPLVWGYIMSwsqqNDVAWVSWWSLSLFCMVALYQSYK 564
Cdd:cd17330 292 SVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYS----FLGPGVPFLLAAGLLLIALFLLSL 349
 
Name Accession Description Interval E-value
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 23-564 1.85e-68

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 225.92  E-value: 1.85e-68
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10383787  23 VSLVRFSEPIAFSSLFPYVYFMVRDFNiapNDAQVSKYSGYLSSSFALCQVISAYHWGRFSEKHGRKITLTCGLIGTSVS 102
Cdd:cd17330   1 LFLVVFLDALGFGIVFPVLPFYVREFN---KLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVS 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10383787 103 LLILGFSRNFYQALVARSLMGLLNGNVGVIRTIIGEIATERKhQALAFSTMPLLFQFGAVVGPMIGGFLVfrdgtmnevp 182
Cdd:cd17330  78 YVLLGLSRNLWLLFLARFLDGLTGGNVSVAQAYIADITDEEE-RAKAFGIISAAFGLGFILGPALGGFLS---------- 146

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10383787 183 lwfphfakriiRSYPYALPNVVVCMFLMFGLTNATLFLeethpafkdrrdyglevgdfikknifgiqpkrrpwqkriqdd 262
Cdd:cd17330 147 -----------TPYGYALPFLVAAALALLNLVLVLFFL------------------------------------------ 173

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10383787 263 senihhrnenvnsirgqdseedensplvnttndddtesiqsidpiltrrqsvglirtyslheptdavhanidtapdgcke 342
Cdd:cd17330     --------------------------------------------------------------------------------

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10383787 343 ssifhhvfhTKVFYPISVNFIMALHLIVYNEFLPVFLAYDLavdpenpkklaskfpwkisggiGYEPEQTGTLLSTTGIF 422
Cdd:cd17330 174 ---------PPLRRLLLVYFLIALAFAGLESVFSLFLKDRF----------------------GFSPSQIGLLLALVGIA 222

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10383787 423 GCFVVIFIFPIVDRNFDCLTIFRTLVKLYPIMYVMVPYVVFLQneripswytvvYLYIITGIKTFCGALTSPQIMLLIHN 502
Cdd:cd17330 223 GILAQLLLIPRLAKRLGERKLLRLGLLLAIIGLLLLPFASSVP-----------LLVLAAAILAFGTGIVFPALSALLSK 291

                       490       500       510       520       530       540
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 10383787 503 SSPLSCRSVINGATISISASARFIGPLVWGYIMSwsqqNDVAWVSWWSLSLFCMVALYQSYK 564
Cdd:cd17330 292 SVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYS----FLGPGVPFLLAAGLLLIALFLLSL 349
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
15-172 9.94e-20

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 90.80  E-value: 9.94e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10383787  15 FPWVQLVVVSLVRFSEPIAFSSLFPYVYFMVRDFNIAPNDAqvskysGYLSSSFALCQVISAYHWGRFSEKHGRKITLTC 94
Cdd:COG2814   7 RRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQA------GLVVTAYLLGAALGAPLAGRLADRFGRRRVLLL 80

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 10383787  95 GLIGTSVSLLILGFSRNFYQALVARSLMGLLNG-NVGVIRTIIGEIATERkHQALAFSTMPLLFQFGAVVGPMIGGFLV 172
Cdd:COG2814  81 GLLLFALGSLLCALAPSLWLLLAARFLQGLGAGaLFPAALALIADLVPPE-RRGRALGLLGAGLGLGPALGPLLGGLLA 158
MFS_1 pfam07690
Major Facilitator Superfamily;
23-172 2.28e-17

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 83.62  E-value: 2.28e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10383787    23 VSLVRFSEPIAFSSLFP-YVYFMVRDFNIAPNDAqvskysGYLSSSFALCQVISAYHWGRFSEKHGRKITLTCGLIGTSV 101
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPaLPLLLAEDLGISPTEI------GLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFAL 74

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 10383787   102 SLLILGFSRNFYQALVARSLMGLLNGNV-GVIRTIIGEIaTERKHQALAFSTMPLLFQFGAVVGPMIGGFLV 172
Cdd:pfam07690  75 GLLLLLFASSLWLLLVLRVLQGLGAGALfPAALALIADW-FPPEERGRALGLVSAGFGLGAALGPLLGGLLA 145
PRK09874 PRK09874
multidrug efflux MFS transporter MdtG;
20-171 4.42e-12

multidrug efflux MFS transporter MdtG;


Pssm-ID: 182127 [Multi-domain]  Cd Length: 408  Bit Score: 68.41  E-value: 4.42e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10383787   20 LVVVSLVRFSEPIAFSSLFPYVYFMVRDFNIAPNDAqVSKYSGYLSSSFALCQVISAYHWGRFSEKHGRKITLTCGLIGT 99
Cdd:PRK09874  16 LTVAWLGCFLTGAAFSLVMPFLPLYVEQLGVTGHSA-LNMWSGLVFSITFLFSAIASPFWGGLADRKGRKIMLLRSALGM 94

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 10383787  100 SVSLLILGFSRNFYQALVARSLMGLLNGNVGVIRTIigeIATE--RKHQALAFSTMPLLFQFGAVVGPMIGGFL 171
Cdd:PRK09874  95 GIVMVLMGLAQNIWQFLILRALLGLLGGFVPNANAL---IATQvpRNKSGWALGTLSTGGVSGALLGPLAGGLL 165
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 47-225 4.52e-07

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 52.36  E-value: 4.52e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10383787    47 DFNIAPNDAqvskysGYLSSSFALCQVISAYHWGRFSEKHGRKITLTCGLIGTSVSLLILGFSRNFYQALVARSLMGL-L 125
Cdd:TIGR00895  46 EWGLDPVQL------GFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLgL 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10383787   126 NGNVGVIRTIIGEIATERkHQALAFSTMPLLFQFGAVVGPMIGGFLVfrdgtmnevplwfPHFAKRIIRSYPYALPnVVV 205
Cdd:TIGR00895 120 GGLMPNLNALVSEYAPKR-FRGTAVGLMFCGYPIGAAVGGFLAGWLI-------------PVFGWRSLFYVGGIAP-LLL 184

                         170       180
                  ....*....|....*....|
gi 10383787   206 CMFLMFGLTNATLFLEETHP 225
Cdd:TIGR00895 185 LLLLMRFLPESIDFLVSKRP 204
 
Name Accession Description Interval E-value
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 23-564 1.85e-68

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 225.92  E-value: 1.85e-68
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10383787  23 VSLVRFSEPIAFSSLFPYVYFMVRDFNiapNDAQVSKYSGYLSSSFALCQVISAYHWGRFSEKHGRKITLTCGLIGTSVS 102
Cdd:cd17330   1 LFLVVFLDALGFGIVFPVLPFYVREFN---KLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVS 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10383787 103 LLILGFSRNFYQALVARSLMGLLNGNVGVIRTIIGEIATERKhQALAFSTMPLLFQFGAVVGPMIGGFLVfrdgtmnevp 182
Cdd:cd17330  78 YVLLGLSRNLWLLFLARFLDGLTGGNVSVAQAYIADITDEEE-RAKAFGIISAAFGLGFILGPALGGFLS---------- 146

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10383787 183 lwfphfakriiRSYPYALPNVVVCMFLMFGLTNATLFLeethpafkdrrdyglevgdfikknifgiqpkrrpwqkriqdd 262
Cdd:cd17330 147 -----------TPYGYALPFLVAAALALLNLVLVLFFL------------------------------------------ 173

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10383787 263 senihhrnenvnsirgqdseedensplvnttndddtesiqsidpiltrrqsvglirtyslheptdavhanidtapdgcke 342
Cdd:cd17330     --------------------------------------------------------------------------------

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10383787 343 ssifhhvfhTKVFYPISVNFIMALHLIVYNEFLPVFLAYDLavdpenpkklaskfpwkisggiGYEPEQTGTLLSTTGIF 422
Cdd:cd17330 174 ---------PPLRRLLLVYFLIALAFAGLESVFSLFLKDRF----------------------GFSPSQIGLLLALVGIA 222

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10383787 423 GCFVVIFIFPIVDRNFDCLTIFRTLVKLYPIMYVMVPYVVFLQneripswytvvYLYIITGIKTFCGALTSPQIMLLIHN 502
Cdd:cd17330 223 GILAQLLLIPRLAKRLGERKLLRLGLLLAIIGLLLLPFASSVP-----------LLVLAAAILAFGTGIVFPALSALLSK 291

                       490       500       510       520       530       540
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 10383787 503 SSPLSCRSVINGATISISASARFIGPLVWGYIMSwsqqNDVAWVSWWSLSLFCMVALYQSYK 564
Cdd:cd17330 292 SVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYS----FLGPGVPFLLAAGLLLIALFLLSL 349
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
15-172 9.94e-20

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 90.80  E-value: 9.94e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10383787  15 FPWVQLVVVSLVRFSEPIAFSSLFPYVYFMVRDFNIAPNDAqvskysGYLSSSFALCQVISAYHWGRFSEKHGRKITLTC 94
Cdd:COG2814   7 RRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQA------GLVVTAYLLGAALGAPLAGRLADRFGRRRVLLL 80

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 10383787  95 GLIGTSVSLLILGFSRNFYQALVARSLMGLLNG-NVGVIRTIIGEIATERkHQALAFSTMPLLFQFGAVVGPMIGGFLV 172
Cdd:COG2814  81 GLLLFALGSLLCALAPSLWLLLAARFLQGLGAGaLFPAALALIADLVPPE-RRGRALGLLGAGLGLGPALGPLLGGLLA 158
MFS_1 pfam07690
Major Facilitator Superfamily;
23-172 2.28e-17

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 83.62  E-value: 2.28e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10383787    23 VSLVRFSEPIAFSSLFP-YVYFMVRDFNIAPNDAqvskysGYLSSSFALCQVISAYHWGRFSEKHGRKITLTCGLIGTSV 101
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPaLPLLLAEDLGISPTEI------GLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFAL 74

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 10383787   102 SLLILGFSRNFYQALVARSLMGLLNGNV-GVIRTIIGEIaTERKHQALAFSTMPLLFQFGAVVGPMIGGFLV 172
Cdd:pfam07690  75 GLLLLLFASSLWLLLVLRVLQGLGAGALfPAALALIADW-FPPEERGRALGLVSAGFGLGAALGPLLGGLLA 145
MFS_MFSD9 cd17390
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ...
 23-176 1.14e-15

Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340948 [Multi-domain]  Cd Length: 350  Bit Score: 78.81  E-value: 1.14e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10383787  23 VSLVRFSEPIAFSSLFPYVYFMVRDFNIAPNDAqvskysGYLSSSFALCQVISAYHWGRFSEKHGRKITLTCGLIGTSVS 102
Cdd:cd17390   1 LYLVGFLDLFGVSMILPLLSTHIRSLGASPTVI------GLIGSVYGALQLFSSPLVGSWSDVVGRRPVLLICLLLTALG 74

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 10383787 103 LLILGFSRNFYQALVARSLMGLLNGNVGVIRTIIGEIATERKhQALAFSTMPLLFQFGAVVGPMIGGFLVFRDG 176
Cdd:cd17390  75 YVLLGFSTSLALLFLSRIPLGIFKHTQSLCKAYLSDLVSEQE-RSRVLGRFNAASSLGFILGPVVGGHLAETDG 147
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 62-176 5.04e-15

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 77.23  E-value: 5.04e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10383787  62 GYLSSSFALCQVISAYHWGRFSEKHGRKITLTCGLIGTSVSLLILGFSRNFYQALVARSLMGLLNGNVGVIR-TIIGEIA 140
Cdd:cd17325  34 GLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASAAVWPAAmALIADIA 113

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 10383787 141 TERKhQALAFSTMPLLFQFGAVVGPMIGGFLVFRDG 176
Cdd:cd17325 114 PPEE-RGRAMGIFSSAIGLGFLIGPLLGGLLADALG 148
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 17-172 1.01e-14

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 75.23  E-value: 1.01e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10383787  17 WVQLVVVSLVRFSEPIAFSSLFPYVYFMVRDFNIAPNDAQVskysgyLSSSFALCQVISAYHWGRFSEKHGRKITLTCGL 96
Cdd:COG0477  13 RRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGW------IVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGL 86

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 10383787  97 IGTSVSLLILGFSRNFYQALVARSLMGL-LNGNVGVIRTIIGEIATERKhQALAFSTMPLLFQFGAVVGPMIGGFLV 172
Cdd:COG0477  87 LLFGLASLLCGLAPSPELLIAARALQGIgAGGLMPGALALIAELFPARE-RGRALGLWGAAIGLGLALGPLLGGLLV 162
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
15-172 1.12e-14

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 75.68  E-value: 1.12e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10383787  15 FPWVQLVVVSLVRFSEPIAFSSLFPYVYFMVRDFNIapNDAQVskysGYLSSSFALCQVISAYHWGRFSEKHGRKITLTC 94
Cdd:COG2271   7 YRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGL--SAAQL----GLLASAFFLGYALGQIPAGLLADRFGRRRVLAI 80

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 10383787  95 GLIGTSVSLLILGFSRNFYQALVARSLMGLLNG-NVGVIRTIIGEIATeRKHQALAFSTMPLLFQFGAVVGPMIGGFLV 172
Cdd:COG2271  81 GLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAgFFPAALKLIAEWFP-PKERGRALGIFNAGGPLGGALAPPLLGWLL 158
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
 32-172 1.29e-14

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 75.76  E-value: 1.29e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10383787  32 IAFSSLFPYVYFMVRDFNIAPNDaQVSKYSGYLSSSFALCQVISAYHWGRFSEKHGRKITLTCGLIGTSVSLLILGFSRN 111
Cdd:cd17391  10 IGFSLIAPFLPLYIEQLGVTSGG-LVELWSGLAFSSTFLVSAIFSPIWGRLADRYGRKPMLLRASLGMAIVIGLMAFVTN 88

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 10383787 112 FYQALVARSLMGLLNGNVGVIRTIIGeIATERKHQALAFSTMPLLFQFGAVVGPMIGGFLV 172
Cdd:cd17391  89 VWQLLILRLLQGVFSGYVPNATALIA-SQTPKEKSGWALGTLSTGVVAGTLIGPLLGGFLA 148
MFS_MFSD10 cd17389
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ...
 60-227 5.82e-13

Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340947 [Multi-domain]  Cd Length: 391  Bit Score: 70.77  E-value: 5.82e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10383787  60 YSGYLSSSFALCQVISAYHWGRFSEKHGRKITLTCGLIGTSVSLLILGFSRNFYQALVARSLMGLLNGNVGVIRTIIGEI 139
Cdd:cd17389  65 FGGLIGSLFSLLQFLSSPITGAASDVYGRKPVLLLTMIGLAISYALWAVSRSFTIFLLSRIVGGISKGNVSLSTAIVADV 144

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10383787 140 AT-ERKHQALAFstMPLLFQFGAVVGPMIGGFLVFRDGTMNEvplwfphfakriirsYPYALPNVVVCMFLMFGLTNATL 218
Cdd:cd17389 145 TSpKKRSKGMAL--IGVAFSLGFIIGPMIGAYFASFTRSLGE---------------VFFSMPALFALVLALADLLFIFF 207


                ....*....
gi 10383787 219 FLEETHPAF 227
Cdd:cd17389 208 FLPETLPSN 216
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 20-172 3.28e-12

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 68.37  E-value: 3.28e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10383787  20 LVVVSLVRFSEPIAFSSLFPYV-YFMVRDFNIapNDAQVskysGYLSSSFALCQVISAYHWGRFSEKHGRKITLTCGLIG 98
Cdd:cd17325 201 LLALFLAIFVLAFAFGALEPFLpLYAAELGGL--SPAQI----GLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLL 274

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 10383787  99 TSVSLLILGFSRNFYQALVARSLMGLLNGNVGV-IRTIIGEIATERkHQALAFSTMPLLFQFGAVVGPMIGGFLV 172
Cdd:cd17325 275 SAVALLLLPLATSFWLLLLLLALLGLGLGLVFPaTLALLADIVPPE-GRGTAMGLFNTAFSLGMVLGPLLGGFLY 348
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 23-185 4.06e-12

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 68.22  E-value: 4.06e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10383787  23 VSLVRFSEPIAFSSLFPYVYFMVRDFNIapNDAQVskysGYLSSSFALCQVISAYHWGRFSEKHGRKITLTCGLIGTSVS 102
Cdd:cd06174   1 LLLGFFLTGLARGLISPLLPALLQSFGL--SASQL----GLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALG 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10383787 103 LLILGFSRNFYQALVARSLMGLLNGNVGVIRTIIGEIATERKHQALAFSTMPLLFQFGAVVGPMIGGFLVFRDGTMNEVP 182
Cdd:cd06174  75 ALLFAFAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAV 154


                ...
gi 10383787 183 LWF 185
Cdd:cd06174 155 FLI 157
PRK09874 PRK09874
multidrug efflux MFS transporter MdtG;
20-171 4.42e-12

multidrug efflux MFS transporter MdtG;


Pssm-ID: 182127 [Multi-domain]  Cd Length: 408  Bit Score: 68.41  E-value: 4.42e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10383787   20 LVVVSLVRFSEPIAFSSLFPYVYFMVRDFNIAPNDAqVSKYSGYLSSSFALCQVISAYHWGRFSEKHGRKITLTCGLIGT 99
Cdd:PRK09874  16 LTVAWLGCFLTGAAFSLVMPFLPLYVEQLGVTGHSA-LNMWSGLVFSITFLFSAIASPFWGGLADRKGRKIMLLRSALGM 94

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 10383787  100 SVSLLILGFSRNFYQALVARSLMGLLNGNVGVIRTIigeIATE--RKHQALAFSTMPLLFQFGAVVGPMIGGFL 171
Cdd:PRK09874  95 GIVMVLMGLAQNIWQFLILRALLGLLGGFVPNANAL---IATQvpRNKSGWALGTLSTGGVSGALLGPLAGGLL 165
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 20-172 4.67e-11

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 64.94  E-value: 4.67e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10383787  20 LVVVSLVRFSEPIAFSSLFPYVY-FMVRDFNIApndaqvSKYSGYLSSSFALCQVISAYHWGRFSEKHGRKITLTCGLIG 98
Cdd:cd17329   1 LWVLLIGSFLNRLGFFMVWPFMAiYLHQQLGLS------ASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLL 74

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 10383787  99 TSVSLLILGFSRNFYQALVARSLMGLLNGNVG-VIRTIIGEIATErKHQALAFSTMPLLFQFGAVVGPMIGGFLV 172
Cdd:cd17329  75 RALGFALLGFAHSPWLFAIALVLTGFGGGLFEpASEAMIADVTTP-ENRTRAFSLLYWAINLGVAIGPLLGGLLL 148
MFS_TetA cd17388
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ...
 44-171 2.14e-10

Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340946 [Multi-domain]  Cd Length: 385  Bit Score: 62.65  E-value: 2.14e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10383787  44 MVRDFniAPNDAQVSKYSGYLSSSFALCQVISAYHWGRFSEKHGRKITLTCGLIGTSVSLLILGFSRNFYQALVARSLMG 123
Cdd:cd17388  25 LLREF--VGDSADAATHYGVLLALYALMQFIFAPILGALSDRFGRRPVLLLSLAGAALDYLLMAFAPTLWWLYLGRIIAG 102

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 10383787 124 LLNGNVGVIRTIIGEIATERKhQALAFSTMPLLFQFGAVVGPMIGGFL 171
Cdd:cd17388 103 ITGATGAVAAAYIADVTPPEQ-RARNFGLLGAAFGLGFIAGPALGGLL 149
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
15-161 2.54e-10

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 62.30  E-value: 2.54e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10383787  15 FPWVQLVVVSLVRFSEPIAFSSLFPYV-YFMVRDFNIAPNDAqvskysGYLSSSFALCQVISAYHWGRFSEKHGRKITLT 93
Cdd:COG2814 204 LRRPRLLLLLLLAFLLGFGFFALFTYLpLYLQEVLGLSASAA------GLLLALFGLGGVLGALLAGRLADRFGRRRLLL 277

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 10383787  94 CGLIGTSVSLLILGFSRNFYQALVARSLMGLLNG-NVGVIRTIIGEIATERkHQALAFSTMPLLFQFGA 161
Cdd:COG2814 278 IGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGlLFPLLQALVAELAPPE-ARGRASGLYNSAFFLGG 345
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
2-172 4.44e-10

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 62.23  E-value: 4.44e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10383787   2 ARQKLTFKEQMDGF----PWVQLVVVSLVRFsepIAFSSLFPY-VYFMVRDFNIAPNdaqvskYSGYLSSSFALCQVISA 76
Cdd:COG2211 211 EEEKVSLKESLKALlknrPFLLLLLAYLLFF---LALALVAALlLYYFKYVLGLSAA------LVGLLLALYFLAALLGA 281

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10383787  77 YHWGRFSEKHGRKITLTCGLIGTSVSLLILGFSR--NFYQALVARSLMGLLNGNVGVIRTII-------GEIATERKHQA 147
Cdd:COG2211 282 PLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGpgNLWLLLVLAALAGIGLGAILVLPWAMladvvdyDEWKTGRRREG 361

                       170       180
                ....*....|....*....|....*
gi 10383787 148 LAFSTMPLLFQFGAVVGPMIGGFLV 172
Cdd:COG2211 362 LYFGIFTFAIKLGQALAGALAGLLL 386
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 44-173 8.91e-10

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 60.67  E-value: 8.91e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10383787  44 MVRDFNIAPNDAQVSkYSGYLSSsFALCQVIsayhWGRFSEKHGRKITLTCGLIGTSVSLLILGFSRNFYQALVARSLMG 123
Cdd:cd17320  25 IARDLGASASAVQLT-LSAYLLG-FALGQLL----YGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQG 98

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 10383787 124 LLNGNVGVI-RTIIGEIATERKhQALAFSTMPLLFQFGAVVGPMIGGFLVF 173
Cdd:cd17320  99 LGAAAGSVVaRAIVRDLYSGAE-LAKIFSLLMMILAIAPALAPLLGGLLLL 148
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 44-172 9.90e-10

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 60.65  E-value: 9.90e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10383787  44 MVRDFNIAPNDAQ--VSKYSgyLSssFALCQVIsayhWGRFSEKHGRKITLTCGLIGTSVSLLILGFSRNFYQALVARSL 121
Cdd:cd17321  22 IARDLGASPSQLQwvVNAYL--LA--FAALLLL----AGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAARAL 93

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 10383787 122 MG-----LLNGNVGVIRTIIGEiaterKHQALAFSTMPLLFQFGAVVGPMIGGFLV 172
Cdd:cd17321  94 QGigaaaIMPASLALIAATFPG-----ERRGRALGLWGAVVGIGAALGPLLGGLLL 144
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
17-175 1.03e-09

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 60.64  E-value: 1.03e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10383787  17 WVQLVVVSLVRFSEPIAFSSLFPYVYFMVRDFNIapNDAQvskySGYLSSSFALCQVISAYHWGRFSEKHGRKITLTCGL 96
Cdd:COG0738   7 RRALIAIYLLFFLWGFATALWGPLIPALKDAFGL--SDAQ----AGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10383787  97 IGTSVSLLILGFSRNFYQALVARSLMGLLNGNVGV-IRTIIGEIatERKHQALAFSTMPLLFQFGAVVGPMIGGFLVFRD 175
Cdd:COG0738  81 LLMALGLLLFALAPSYPLLLLALFLLGLGLGLLDVaANPYVAAL--GPETAASRLNLLHAFFSLGALLGPLLGGLLILLG 158
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
 61-172 4.38e-09

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 58.34  E-value: 4.38e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10383787  61 SGYLSSSFALCQVISAYHWGRFSEKHGRKITLTCGLIGTSVSLLILGFSRNFYQALVARSLMGLLNGNVG-VIRTIIGEI 139
Cdd:cd17502  32 VSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGRAIQGIGGGGLMsLAFIIIADL 111

                        90       100       110
                ....*....|....*....|....*....|...
gi 10383787 140 ATERkHQALAFSTMPLLFQFGAVVGPMIGGFLV 172
Cdd:cd17502 112 VPPR-ERGKYQGYIGAVFGIASVAGPLIGGAFT 143
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
 46-171 1.60e-08

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 56.86  E-value: 1.60e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10383787  46 RDFNIAPndaqvsKYSGYLSSSFALCQVISAYHWGRFSEKHGRKITLTCGLIGTSVSLLILGFSRNFYQALVARSLMGLL 125
Cdd:cd17328  27 SDFLIDD------SLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFRALVGIG 100

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 10383787 126 NGNVGVI-RTIIGEIATERKhQALAFStmplLFQFGAVVGPMIGGFL 171
Cdd:cd17328 101 EASYSPIaPTIIADLFPKEK-RTRALG----VFYFAIPLGSGLGYVV 142
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
61-172 2.63e-08

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 56.03  E-value: 2.63e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10383787  61 SGYLSSSFALCQVISAYHWGRFSEKHGR--KITLTCGLIGTSVSLLILGFSRNFYQALVARSLMGL-LNGNVGVIRTIIG 137
Cdd:COG2271 218 AGLLLSLPFLAGIVGSLLGGWLSDRLGRrrKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFgLGGAFGLLWALAA 297

                        90       100       110
                ....*....|....*....|....*....|....*
gi 10383787 138 EIATeRKHQALAFSTMPLLFQFGAVVGPMIGGFLV 172
Cdd:COG2271 298 ELFP-KKARGTASGLVNTFGFLGGALGPLLVGYLL 331
MFS_Set cd17471
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ...
 32-172 2.09e-07

Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341024 [Multi-domain]  Cd Length: 371  Bit Score: 53.32  E-value: 2.09e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10383787  32 IAFSSLFPY-VYFMVRDFNIAPndaqvsKYSGYLSSSFALCQVISAYHWGRFSEKHG-RKITLTCGLIGTSVSLLILGFS 109
Cdd:cd17471  10 LAGAFVLPYlSLFLTEELGASP------LQIGIFMTLSALSGIVVSQWLGRLSDRGGdRKPLILLALLAGALGYLLFAFL 83

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 10383787 110 RNFYQAL-VARSLMGLLNGNVGVIRTIIGEIATE--RKHQALAFSTMPLLFQFGAVVGPMIGGFLV 172
Cdd:cd17471  84 RNYWVLLlVGVVLLSLGAAAFPQLFALAREYADRssGRDATLFNSVLRAAFSLAWVIGPPLAFLLL 149
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 44-171 2.29e-07

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 53.32  E-value: 2.29e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10383787  44 MVRDFNIAPNDAqvskysGYLSSSFALCQVISAYHWGRFSEKHGRKITLTCGLIGTSVSLLILGFSRNFYQALVARSLMG 123
Cdd:cd17324  25 IARDFGVSVAQA------GLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAG 98

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 10383787 124 LLNGNV-GVIRTIIGEIATERKHQ---ALAFSTMPLlfqfGAVVGPMIGGFL 171
Cdd:cd17324  99 LAHGGFwAIAAAYAADLVPPEKRGraiGLVFSGLTL----GLVLGRPLGGLL 146
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 20-172 2.61e-07

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 52.96  E-value: 2.61e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10383787  20 LVVVSLVRFSEPIAFSSLFPYVYFMVRDFNIapNDAQVskysGYLSSSF----ALCQVISayhwGRFSEKHGRKITLTCG 95
Cdd:cd17474   1 LYAVFFATLLAVLGVSIVDPILPAIAEALGA--SPAQV----GLLITAFtlpaAVLMPVA----GVLADRFGRKKVLLPG 70

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 10383787  96 LIGTSVSLLILGFSRNFYQALVARSLMGLLNGNVGVIR-TIIGEIATERK-HQALAFSTMPLlfQFGAVVGPMIGGFLV 172
Cdd:cd17474  71 LLLFGIGGLLCGLSDSFALLLAGRALQGIGAAGLGPLAlTLIGDLFEGGErAKAMGLYEAAL--GLGIAVGPLLGGLLA 147
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 47-225 4.52e-07

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 52.36  E-value: 4.52e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10383787    47 DFNIAPNDAqvskysGYLSSSFALCQVISAYHWGRFSEKHGRKITLTCGLIGTSVSLLILGFSRNFYQALVARSLMGL-L 125
Cdd:TIGR00895  46 EWGLDPVQL------GFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLgL 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10383787   126 NGNVGVIRTIIGEIATERkHQALAFSTMPLLFQFGAVVGPMIGGFLVfrdgtmnevplwfPHFAKRIIRSYPYALPnVVV 205
Cdd:TIGR00895 120 GGLMPNLNALVSEYAPKR-FRGTAVGLMFCGYPIGAAVGGFLAGWLI-------------PVFGWRSLFYVGGIAP-LLL 184

                         170       180
                  ....*....|....*....|
gi 10383787   206 CMFLMFGLTNATLFLEETHP 225
Cdd:TIGR00895 185 LLLLMRFLPESIDFLVSKRP 204
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 32-171 4.90e-07

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 52.43  E-value: 4.90e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10383787  32 IAFSSLFPYVYFMVRDFNiapndAQVSKYSGYLSSSFALCQVISAYHWGRFSEKH-GRKITLTCGLIGTSVSLLILGFSR 110
Cdd:cd06174 217 LAYYSFSTLLPLFLLDLG-----GLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLiGRKPLLLIGLLLMALGLALLLLAP 291

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 10383787 111 NFYQALVARSLMGLLNGNVGVIRTIIGEIATERKHQALAFSTMPLLFQFGAVVGPMIGGFL 171
Cdd:cd06174 292 SLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFL 352
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
16-172 7.55e-07

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 51.81  E-value: 7.55e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10383787  16 PWVQLVVVSLVRFSEPIAFSSLFPYVYFMVRDFNIapNDAQVskysGYLSSSFALCQVISAYHWGRFSEKHGRKITLTCG 95
Cdd:COG2223   3 RWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGL--SAAQL----GLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIG 76

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 10383787  96 LIGTSVSLLILGFSRNFYQALVARSLMGLLNG-NVGVIRTIIGEIATERKhQALAFSTMPLLFQFGAVVGPMIGGFLV 172
Cdd:COG2223  77 LLLLGIGLLLLALAVSYWLLLLLGLLLGIGGGgSFAVGIALVSKWFPPDR-RGLALGLAAGGGNLGAAVAAFLAPLLI 153
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 61-173 1.19e-06

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 51.06  E-value: 1.19e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10383787  61 SGYLSSSFALCQVISAYHWGRFSEKHGRKITLTCGLIGTSVSLLILGFSRNFYQALVARSLMGL-LNGNVGVIRTIIGEI 139
Cdd:cd17316  38 TGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVLRFLQGIgIGGEYPGASTYVAEF 117

                        90       100       110
                ....*....|....*....|....*....|....
gi 10383787 140 ATERKHqalafSTMPLLFQFGAVVGPMIGGFLVF 173
Cdd:cd17316 118 APSKRR-----GFALGLLQSGWALGALLAALVAS 146
MFS_FucP_MFSD4_like cd17333
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ...
 62-172 1.30e-06

Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340891 [Multi-domain]  Cd Length: 372  Bit Score: 50.78  E-value: 1.30e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10383787  62 GYLSSSFALCQVISAYHWGRFSEKHGRKITLTCGLIGTSVSLLILGFSRNFYQALVARSLMGLLNG-NVGVIRTIIGEIA 140
Cdd:cd17333  34 SVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVVLMFLAGLGAGiLDTGANTFVGALF 113

                        90       100       110
                ....*....|....*....|....*....|..
gi 10383787 141 TERKHQALAFstMPLLFQFGAVVGPMIGGFLV 172
Cdd:cd17333 114 EESSATRLNV--LHGFFGLGALIGPLIATSLL 143
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 20-178 1.52e-06

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 50.69  E-value: 1.52e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10383787  20 LVVVSLVRFsepIAFSSLFPYVYFMVRDFNIAPndaqvsKYSGYLSSSFALCQVISAYHWGRFSEKHGRKITLTCGLIGT 99
Cdd:cd06173 214 LLALALFAL---LGGALTVLLPLLAKEVLGGGA------AGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLL 284

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 10383787 100 SVSLLILGFSRNFYQALVARSLMGLLNGNVGVIRTIIGEIATERKHQALAFSTMPLLFQFGAVVGPMIGGFLVFRDGTM 178
Cdd:cd06173 285 GLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLS 363
MFS_TRI12_like cd06179
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ...
 21-172 2.30e-06

Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340868 [Multi-domain]  Cd Length: 518  Bit Score: 50.32  E-value: 2.30e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10383787  21 VVVSLVRFSEPIAFSSLFPYVYFMVRDFNIAPNdaqvskySGYLSSSFALCQVISAYHWGRFSEKHGRKITLTCGLIGTS 100
Cdd:cd06179   1 AALCLAYFAQLFGVTLPAAVLPFIVADLGPSSN-------STWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGV 73

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 10383787 101 VSLLILGFSRNFYQALVARSLMGLLNGNVGVIRTIIGEIATeRKHQALAFSTMPLLFQFGAVVGPMIGGFLV 172
Cdd:cd06179  74 VGSIVAGTAKSVNMLIGGQALIGIGAGTQGLGAAVASELVP-NKYRGLVQGVVNLVASPGSALGPLIAGALV 144
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 62-171 3.10e-06

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 49.88  E-value: 3.10e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10383787  62 GYLSSSFALCQVISAYHWGRFSEKH-GRKITLTCGLIGTSVSLLILGFSRNFYQALVARSLMGLLNG-NVGVIRTIIGEI 139
Cdd:cd17474 237 GLLFAGWSVLLALGSLFVGRLLKKRfGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGlNLPLLTTLVTEL 316

                        90       100       110
                ....*....|....*....|....*....|...
gi 10383787 140 A-TERKHQALAFSTMplLFQFGAVVGPMIGGFL 171
Cdd:cd17474 317 ApEEERGTASSLYNF--VRFLGQAVGPLLFGLL 347
MFS_MFSD8 cd17326
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) ...
 32-173 3.32e-06

Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) domain-containing protein 8 (MFSD8) is also called ceroid-lipofuscinosis neuronal protein 7 (CLN7). It is a polytopic lysosomal membrane protein that may transport small solutes by using chemiosmotic ion gradients. Mutations in MFSD8/CLN7 cause a variant of late-infantile neuronal ceroid lipofuscinoses (vLINCL), a neurodegenerative lysosomal storage disorder. Some variants are associated with nonsyndromic autosomal recessive macular dystrophy. MFSD8/CLN7 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340884 [Multi-domain]  Cd Length: 374  Bit Score: 49.51  E-value: 3.32e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10383787  32 IAFSSLFPYVYFMVRDfniAPNDaqvskYSGYLSSSFALCQVISAYHWGRFSEK-HGRKITLTCGLIGTSVSLLILGFSR 110
Cdd:cd17326  17 IVLTSIWPYLQKIDPT---ATAS-----FFGWVVAAYSLGQLVFSPVFGYWSNKtSSVKEPLIVSILIAIVGNILYALAE 88

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 10383787 111 NF-----YQALVARSLMGLLNGNVGVIRTIIGEiATERKHQALAFSTMPLLFQFGAVVGPMIGGFLVF 173
Cdd:cd17326  89 YFpsnrkYVMLVARFLIGVGAGNVAVLRAYVAA-ASTLKDRTRAMAVISAAQALGFIVGPALQAAFTP 155
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 32-176 4.53e-06

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 49.08  E-value: 4.53e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10383787  32 IAFSSLFPYV-YFMVRDFNIAPNDAqvskySGYLSSsFALCQVISAYHWGRFSEKHGRKITLTCGLIGTSVSLLILGFSR 110
Cdd:cd17324 212 GGFFALYTYLaPFLTDVPGFSSSAI-----IGLLLL-FGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGP 285

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 10383787 111 NFYQALVARSLMGLLNGNVGVI-RTIIGEIATERKHQALAFSTmpLLFQFGAVVGPMIGGFLVFRDG 176
Cdd:cd17324 286 SPLLLLVGLVLWGLGFFAAHSAlQTRVLRLAPEARGLASSLYL--AAYNLGGALGAALGGLVLDHGG 350
MFS_SLC22A18 cd17331
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ...
 62-172 1.18e-05

Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340889 [Multi-domain]  Cd Length: 382  Bit Score: 47.98  E-value: 1.18e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10383787  62 GYLSSSFALCQVISAYHWGRFSEKHGRKITLTCGLIGTSVSLLILGFSRNFYQALVARsLMGLLNGNVGVIRTIIGEIaT 141
Cdd:cd17331  38 GYLQTTFSVLQLVGGPLFGRFGDLFGPRAALVLSFLSSALSYLLLAFASSVPMLFLSR-LPSVFMHAMQAAQMVVTDL-T 115

                        90       100       110
                ....*....|....*....|....*....|.
gi 10383787 142 ERKHQALAFSTMPLLFQFGAVVGPMIGGFLV 172
Cdd:cd17331 116 DPGERAAALGRLGLSYGIGMVVGSFLGGLLT 146
MFS_YcxA_like cd17355
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...
 68-176 1.35e-05

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340913 [Multi-domain]  Cd Length: 386  Bit Score: 47.65  E-value: 1.35e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10383787  68 FALCQVISAYHWGRFSEKHGRKITLTCGLIGTSVSLLILGFSRN-FYQALVARSLMGLLNGNVGvirTIIGEIATE---R 143
Cdd:cd17355 254 IGLFNIVGRLLSGWLGDRYSPRRLLAASYALRALGLALLLLLPFpPLALLLFAALFGLGWGATV---PLTAALAARyfgA 330

                        90       100       110
                ....*....|....*....|....*....|...
gi 10383787 144 KHQALAFSTMPLLFQFGAVVGPMIGGFLVFRDG 176
Cdd:cd17355 331 RSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTG 363
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 37-172 1.36e-05

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 47.57  E-value: 1.36e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10383787  37 LFPYVYFMVRDFNIAPNDAqvskysGYLSSSFALCQVISAYHWGRFSEKHGRKITLTCGLIGTSVSLLILGFSRNFYQAL 116
Cdd:cd17504  15 LSPALPTIQREFGTSAAAV------SWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLI 88

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 10383787 117 VARSLMGLLNGNVGVIRTIIGEIATERKhQALAFSTMPLLFQFGAVVGPMIGGFLV 172
Cdd:cd17504  89 AGRALQGIGGAVFPLAFALVREEFPPER-VPVAQGILSATFGIGAGIGLPLGGWIV 143
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 20-176 1.53e-05

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 47.57  E-value: 1.53e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10383787  20 LVVVSLVRFSEPIAFSSLFPYVYFMVRDFNIAPNDAQVSkysgylSSSFALCQVISAYHWGRFSEKHGRKITLTCGLIGT 99
Cdd:cd17323   1 VFIISFLTFVVTFGSSIYSPALPQIAEDFHVSEEVANLG------VSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIF 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10383787 100 SVSLLILGFSRNFYQALVARSLMGLL----NGNVGvirTIIGEIaTERKHQALA---FSTMPLLfqfGAVVGPMIGGFLV 172
Cdd:cd17323  75 VIFQIGCALAPNIAMLIILRFLQGFFgsspLAIGA---GTIADL-FTPEERGKAmgvYSLGPLL---GPALGPIIGGFIT 147


                ....
gi 10383787 173 FRDG 176
Cdd:cd17323 148 QSLG 151
MFS_SLC46 cd17386
Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The ...
 30-171 1.72e-05

Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3) and similar proteins from insects and nematodes. The best-studied member is SLC46A1, also called proton-coupled folate transporter (PCFT), which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. SLC46A2, also called thymic stromal cotransporter protein (TSCOT), is a putative 12-transmembrane protein mainly expressed in the thymic cortex in a specific thymic epithelial cell (TEC) subpopulation. SLC46A3 is a lysosomal membrane protein that functions as a direct transporter of noncleavable antibody maytansine-based catabolites from the lysosome to the cytoplasm. The SLC46 family belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340944 [Multi-domain]  Cd Length: 360  Bit Score: 47.27  E-value: 1.72e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10383787  30 EPIAFSSLFPYVYFMVrdfnIAPNDAQVSKYSGYLSSSFALCQVISAYHWGRFSEKHGRKITLTCGLIGTSVSLLILGFS 109
Cdd:cd17386   5 EPIVFLYMFASVLSGP----VTQNFVYAANFYLYMNLMGSIPPLFSSLFLGSWSDRYGRKPPLLMSLVGLLLSSLILVLI 80

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10383787 110 RNFYQALV------ARSLMGLLNGNVGVIRTIIGEIATERKHQALAFSTMPLLFQFGAV--VGPMIGGFL 171
Cdd:cd17386  81 VYFTTVPSvwwfylSAIPLALFGGFTAFLSASFAYISDISSEKKRTYRMAILEVALGLGgfLGSLLSGHL 150
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
 5-170 1.80e-05

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 47.26  E-value: 1.80e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10383787   5 KLTFKEQMDGFPWVQLVVVSLV-RFSEPIAFSSLFPYVYFMVRDfnIAPNDAQVSKYSGYLSSSFALCQVISAYHWGRFS 83
Cdd:cd17391 187 MVSTKEVWNSVPNPSLLISLFVtTFIIQLANQSIEPILTLYIRQ--LMGDASNLAFISGLVFSATGVSSLLSAPRLGKLG 264

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10383787  84 EKHG-RKITLTCGLIGtSVSLLILGFSRNFYQALVARSLMGLLNGN-VGVIRTIIGEIATER-KHQALAFSTMpllFQF- 159
Cdd:cd17391 265 DRIGhHRILLGALLAS-ALLYIPQAFVQTPWQLGILRFLLGLATGGlLPAINSLLAKITPKEvAGRIFGYNQS---FQYl 340

                       170
                ....*....|.
gi 10383787 160 GAVVGPMIGGF 170
Cdd:cd17391 341 GNVAGPLLGSA 351
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
32-177 1.81e-05

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 47.18  E-value: 1.81e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10383787  32 IAFSSLFPYvyFMVRDFNIAPNDAqvskysGYLSSSFALCQVISAYHWGRFSEKHGRKITLTCGLIGTSVSLLILGFSR- 110
Cdd:COG2223 222 IGFSSWLPP--YLVDQFGLSAATA------GLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALg 293

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 10383787 111 NFYQALVARSLMGLLNG-NVGVIRTIIGEIAtERKHQALAFSTMPLLFQFGAVVGPMIGGFLVFRDGT 177
Cdd:COG2223 294 SLWLFLVLFLLLGLALGgGNGAVFALVPDIF-PTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGS 360
Sugar_tr pfam00083
Sugar (and other) transporter;
54-211 2.51e-05

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 46.88  E-value: 2.51e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10383787    54 DAQVSKYSGYLSSSFALCQVISAYHWGRFSEKHGRKITLTCGLIGTSVSLLILGFS---RNFYQALVARSLMGLlngNVG 130
Cdd:pfam00083  41 LAALSVLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAkgkWSVYQLIVGRVLVGI---GVG 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10383787   131 VIRTI----IGEIATERKHQALAfSTMPLLFQFGAVVGPMIG-GFLVFRDGTMNEVPLWFPhfakriirsypyALPNVVV 205
Cdd:pfam00083 118 GASVLapmyISEIAPKKLRGALG-SLYQLAITFGILLAYIFGlGLNKTSNSDGWRIPLGLQ------------LVPALLL 184


                  ....*.
gi 10383787   206 CMFLMF 211
Cdd:pfam00083 185 IIGLLF 190
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 43-172 3.18e-05

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 46.41  E-value: 3.18e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10383787  43 FMVRDFNIAPNDAqvskysGYLSSSF----ALCQVISayhwGRFSEKHGRKITLTCGLIGTSVSLLILGFSRNFYQALVA 118
Cdd:cd17319  28 TIMKDLGLSPTQY------GLIASAFflgyALFQVPG----GWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVL 97

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 10383787 119 RSLMGLLNG--NVGVIRTIIGEIATERKHQALAFStmpLLFQ-FGAVVGPMIGGFLV 172
Cdd:cd17319  98 RFLLGVAEAgfFPGAIKALAEWFPARERGRATGLF---NSGApLGAAIGPPLSGWLL 151
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 33-185 5.67e-05

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 45.67  E-value: 5.67e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10383787  33 AFSSLFPYVYFMVRDFNIApndaqvskYSGYLSSSFALCQVISAYHWGRFSEKHGRKITLTCGLIGTSVSLLILGFSR-- 110
Cdd:cd17316 195 GLTTFLPTYLQTVLGLSPA--------TSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLLsg 266

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10383787 111 NFYQALVARSLMGLLNGNV-GVIRTIIGEI-ATERKHQALAFStmpllFQFGAVVG----PMIGGFLVFRDGTMneVPLW 184
Cdd:cd17316 267 SPTLLLLLLFILSFFVGGVwGALYAYLAELfPTEVRATGVGLS-----YNLGRLGGggapPLIALLLASTGGTG--VPAL 339


                .
gi 10383787 185 F 185
Cdd:cd17316 340 I 340
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 59-172 9.07e-05

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 44.89  E-value: 9.07e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10383787  59 KYSGYLSSSFALCQVISAYHWGRFSEKHGRKITLTCGLIGTSVSLLILGFSRNFYQALVARSLMGLLNGNV-GVIRTIIG 137
Cdd:cd17489 227 SNAGLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLfPALQALAV 306

                        90       100       110
                ....*....|....*....|....*....|....*
gi 10383787 138 EIATERKHqALAFSTMPLLFQFGAVVGPMIGGFLV 172
Cdd:cd17489 307 DLVPPHRR-GAANGTFFIFFDLGIGLGGLLLGLVA 340
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 13-172 9.52e-05

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 44.87  E-value: 9.52e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10383787  13 DGFPWVQLVVVSLVRFSEPIAFSSLFPYVYFMVRDFNIAPndaqvSKYSGYLSSSFALCQVISAYHWGRFSEKHGRKITL 92
Cdd:cd17473 192 AALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGS-----AALIGLALAIASLAGAIGALLFGRLKRRLGKRRLL 266

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10383787  93 TCGLIGTSVSLLILGFSRNFYQALVARSLMGLLNGNVG--VIRTIIGEIATERKHQALAFSTMplLFQFGAVVGPMIGGF 170
Cdd:cd17473 267 AIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLptLNSWAMSLVPPELRGRAMGIVTS--AFFLGQFLSPLVLGP 344


                ..
gi 10383787 171 LV 172
Cdd:cd17473 345 LV 346
efflux_Bcr_CflA TIGR00710
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ...
 39-172 9.52e-05

drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.


Pssm-ID: 273229 [Multi-domain]  Cd Length: 385  Bit Score: 45.07  E-value: 9.52e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10383787    39 PYVYFMVRDFNIAPNDAQVSkYSGYLSSsFALCQVIsayhWGRFSEKHGRKITLTCGLIGTSVSLLILGFSRNFYQALVA 118
Cdd:TIGR00710  26 PAFPEIAADLSTPASIVQMT-LTLYLLG-FAAGQLL----WGPLSDRYGRRPVLLLGLFIFALSSLGLALSNNIETLLVL 99

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 10383787   119 RSLMGlLNGNVGVIrtIIGEIATE---RKHQALAFSTMPLLFQFGAVVGPMIGGFLV 172
Cdd:TIGR00710 100 RFVQA-FGASAGSV--ISQALVRDiypGEELSRIYSILMPVLALAPAVAPLLGGYIL 153
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
 68-171 1.18e-04

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 44.84  E-value: 1.18e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10383787  68 FALCQVISAYHWGRFSEKHGRKITLTCGLIGTSVSLLILGFSRNFYQALVARSLMGLLNGNV-GVIRTIIGEIATERKHq 146
Cdd:cd17370 243 FNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQeSIERAAVADLVPAELR- 321

                        90       100
                ....*....|....*....|....*
gi 10383787 147 ALAFSTMPLLFQFGAVVGPMIGGFL 171
Cdd:cd17370 322 GTAYGLFNTVVGIGWLLASLIAGYL 346
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 69-172 1.53e-04

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 44.49  E-value: 1.53e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10383787  69 ALCQVISAYHWGRFSEKHGRKITLTCGLIGTSVSLLILGFSRNFYQALVARSLMGLlngNVGVIRTI----IGEIAT-ER 143
Cdd:cd17473  45 ALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGI---GVAGIMTLatalIGDYFEgEE 121

                        90       100
                ....*....|....*....|....*....
gi 10383787 144 KHQALAFSTMPLlfQFGAVVGPMIGGFLV 172
Cdd:cd17473 122 RAKMLGLQSAAM--SLGGVVFLLLGGALA 148
2A0104 TIGR00881
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ...
 42-127 1.74e-04

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273319 [Multi-domain]  Cd Length: 379  Bit Score: 44.29  E-value: 1.74e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10383787    42 YFMVRDFNIAPNDAQ----VSKYS-GYLSSSFALCQVISAYHWGRFSEKHGRKITLTCGLIGTSVSLLILGFSRNFYQAL 116
Cdd:TIGR00881   8 YLVRKNFALAMPYLVeeigLSKTDlGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMA 87

                          90
                  ....*....|.
gi 10383787   117 VARSLMGLLNG 127
Cdd:TIGR00881  88 ALWALNGIFQG 98
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 61-188 5.18e-04

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 42.55  E-value: 5.18e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10383787  61 SGYLSSSFALCQVISAYHWGRFSEKHGRKITLT-CGLIGTSVSLLILGFSRNFYQALVarsLMGLLNGNVGVIRTIIGEI 139
Cdd:cd17477 225 AALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLgCALLGALAALLLPLVPGLPLALLV---LLFLWGGAAGPLYTLALAL 301

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 10383787 140 ATERKHQAL---AFSTMPLLFQFGAVVGPMIGGFLVFRDGtmnevPLWFPHF 188
Cdd:cd17477 302 AGDRLPGDElvaANAALLLLYGLGSVIGPLLAGALMDAFG-----PHGLFLF 348
MFS_1 pfam07690
Major Facilitator Superfamily;
16-165 8.80e-04

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 42.02  E-value: 8.80e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10383787    16 PWVQLVVVSLVRFsepIAFSSLFPYVYFMVRDFNIAPndaqvsKYSGYLSSSFALCQVISAYHWGRFSEKHGRKITLTCG 95
Cdd:pfam07690 201 PVLWLLLALLLFG---FAFFGLLTYLPLYQEVLGLSA------LLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLA 271

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 10383787    96 LIGTSVSLLILGFSRNFYQALVARSLMGLLNGNVGVIRTIIGEIATE---RKHQALAFSTMPLLFQFGAVVGP 165
Cdd:pfam07690 272 LLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDlapKEERGTASGLYNTAGSLGGALGP 344
MFS_SLC18B1 cd17385
Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; ...
 19-172 1.31e-03

Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; Solute carrier family 18 member B1 (SLC18B1) is the fourth member of the SLC18 transporter family, which includes vesicular monoamine transporters and vesicular acetylcholine transporter. It is predominantly expressed in the hippocampus and is associated with vesicles in astrocytes. It actively transports spermine and spermidine by exchange of H(+), and has been suggested to be a vesicular polyamine transporter (VPAT). SLC18B1 belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340943 [Multi-domain]  Cd Length: 390  Bit Score: 41.43  E-value: 1.31e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10383787  19 QLVVVSLVRFSEPIAFSSLFPYVYFMVRDFNIAPndaqvsKYSGYLSSSFALCQVISAYHWGRFSEKHG-RKITLTCGLI 97
Cdd:cd17385 202 SVLLLCLSIVSGSVSLGFLDPTLSPHLRQFKLSP------GQVGLMFLILAGSYAISAPLWGWLSDKKKiPKWLMVIGSI 275

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10383787  98 GTSVSLLILG------FSRNFYQALVARSLMGLLNGnVGVIRTIIGEIATERKHQ-ALAFSTMPLL-------FQFGAVV 163
Cdd:cd17385 276 ITGVGFLLLGpapllpIKSELWMVIIGLVLLGLSLG-AALVPTFPELLNCAREYGfPDNLSTYGLVsglfnaaFSLGAFI 354


                ....*....
gi 10383787 164 GPMIGGFLV 172
Cdd:cd17385 355 GPTLGGFLL 363
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 44-172 1.31e-03

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 41.41  E-value: 1.31e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10383787  44 MVRDFNIAPNDAQvskysgYLSSSFALCQVI----SAYHWGRFSEkhgRKITLTCGLIGTSVSLLIlGFSRNFYQALVAR 119
Cdd:cd17503  22 IMGDLGASLDTVQ------WVITSYLLALAImiplSGWLADRFGT---RRLFLTALALFTLGSLLC-GLAPNLASLIIFR 91

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 10383787 120 SLMGLLNGNVGVI-RTIIGEIATERKH-QALAFSTMPLLFqfGAVVGPMIGGFLV 172
Cdd:cd17503  92 ILQGFGGGVLIPLaQTILLRIYPPEKRgAAMGLVGLVILL--APAIGPTLGGWLT 144
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 61-179 1.35e-03

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 41.40  E-value: 1.35e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10383787  61 SGYLSSSFALCQVISAYHWGRFSEKH---GRKITLTCGLIGTSVSLLILGFSRNFYQALVARSLMG-LLNGNVGVIRTII 136
Cdd:cd17319 217 VGLLAAIPFLAGAIGMILGGRLSDRLlrgARRLVIIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGfGIGAASPVFWSLP 296

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 10383787 137 GEIATeRKHQALAFSTMPLLFQFGAVVGPMIGGFLVFRDGTMN 179
Cdd:cd17319 297 ADLLP-GEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGSYT 338
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 80-171 1.84e-03

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 41.02  E-value: 1.84e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10383787  80 GRFSEKHGRKITLTCGLIGTSVSLLILGFSRNFYQALVARSL---MGLLNGNVGVIRTIIgeIATERKHQALAFSTMPLL 156
Cdd:cd17504 238 GRLIARVGPRRVLLIGLVISAVGLLLLALLHSSLWALVVALLligIGLGLAFASLPNIVV--ESVPPDRTGIATGMNTVL 315

                        90
                ....*....|....*
gi 10383787 157 FQFGAVVGPMIGGFL 171
Cdd:cd17504 316 RTIGSAIGPAIAGAI 330
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
 60-164 2.56e-03

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 40.36  E-value: 2.56e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10383787  60 YSGYLSSSFALCQVISAYHWGRFSEKHGRKITLTCGLIGTSVSLLILGFSRNFYQALVARSLMGL-LNGNVGVIRTIIGE 138
Cdd:cd17371  35 EAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRALAGLgFGGEWAAGAALMAE 114

                        90       100
                ....*....|....*....|....*.
gi 10383787 139 IATERkHQALAFSTMpllfQFGAVVG 164
Cdd:cd17371 115 YVPAR-HRGKALGYV----QSGWAVG 135
MFS_MT3072_like cd17475
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ...
 32-129 3.50e-03

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341028 [Multi-domain]  Cd Length: 378  Bit Score: 39.91  E-value: 3.50e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10383787  32 IAFSSLFPYVYFMVRDFNIapNDAQVskysGYLSSSFALCQVISAYHWGRFSEKHGRKITLTCGLIGTSVSLLILGFSRN 111
Cdd:cd17475  10 LVAQGIPALAPFLQEDLHL--SLAQV----GLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGS 83

                        90
                ....*....|....*...
gi 10383787 112 FYQALVARSLMGLLNGNV 129
Cdd:cd17475  84 YPVLLVLLFLVGAGYGSV 101
MFS_GLUT_like cd17315
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...
 39-173 3.54e-03

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340873 [Multi-domain]  Cd Length: 365  Bit Score: 39.86  E-value: 3.54e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10383787  39 PYVYFMVRDFNIAPNdaqvSKYSGYLSSSFALCQVISAYHWGRFSEKHGRKITLTCGLIGTSVSLLILGFSRNFYQALVA 118
Cdd:cd17315  18 GALLYIAKDLGFGLS----TSLQGLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWVLIVG 93

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 10383787 119 RSLMGLlngNVGVIRTI----IGEIATERKHQALAfstmpLLFQFGAVVGPMIGGFLVF 173
Cdd:cd17315  94 RFLLGL---GVGLASVLvplyISEIAPAKIRGALG-----TLNQLMITFGILLAYLLGL 144
MFS_YajR_like cd17472
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ...
 68-171 4.29e-03

Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341025 [Multi-domain]  Cd Length: 371  Bit Score: 39.89  E-value: 4.29e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10383787  68 FALCQVISAYHWGRFSEKHGRKITLTCGLIGTSVSLLILGFSRNFYQALVARSLMGLlnGNV-GVIRTIIGE-IATERKH 145
Cdd:cd17472  41 YGLTQAIFQIPFGLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQGS--GAIsSVVMALLADlTREENRT 118

                        90       100
                ....*....|....*....|....*...
gi 10383787 146 QALAFSTMP--LLFQFGAVVGPMIGGFL 171
Cdd:cd17472 119 KAMALIGASigIAFAISMVLGPLLAAHL 146
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 80-172 4.40e-03

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 39.49  E-value: 4.40e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10383787  80 GRFSEKHGRKITLTCGLIGTSVSLLILGFSRNFYQALVARSLMGL-LNGNVGVIRTIIGEIATERKhQALAFSTMPLLFQ 158
Cdd:cd17365  55 GPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGLgLGAAMPNAITLVSEYAPARR-RSLAVTLMFCGYP 133

                        90
                ....*....|....
gi 10383787 159 FGAVVGPMIGGFLV 172
Cdd:cd17365 134 LGAALGGFLAAALI 147
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 62-172 4.51e-03

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 39.50  E-value: 4.51e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10383787  62 GYLSSSFALCQVISAYHWGRFSEKHGRKITLTCGLIGTSVSLLILGFSRNFYQALVARSLMGLLNG--NVGVIRTIIGEI 139
Cdd:cd17489  34 GLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGafTTAAATLVADII 113

                        90       100       110
                ....*....|....*....|....*....|...
gi 10383787 140 ATERKHQALAFstMPLLFQFGAVVGPMIGGFLV 172
Cdd:cd17489 114 PPSRRGEGIGY--YGLATTLAMALGPALGLFLY 144
MFS_SLC45_SUC cd17313
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ...
 68-176 4.57e-03

Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340871 [Multi-domain]  Cd Length: 421  Bit Score: 39.92  E-value: 4.57e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10383787  68 FALCQVISAYHWGRFSEKHGRKITLTCGLIGTSVSLLILGFSRNFYQALVARSLMGLLNGNVGVIR-TIIGEIATE-RKH 145
Cdd:cd17313 290 FSLAFLIFSLPIGKLGKKIGRKKVYLIGLVLFAVGMALMALVHNVTVALVLFALGGIGWATININPyPLVSDYHSEsGRG 369

                        90       100       110
                ....*....|....*....|....*....|.
gi 10383787 146 QALAFSTMPLLFQFGAVVGPMIGGFLVFRDG 176
Cdd:cd17313 370 QGTDTGLLNLAISLAQILVSLLAGPIIDVKG 400
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
1-172 7.47e-03

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 39.09  E-value: 7.47e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10383787   1 MARQKLTFKEQMDGFPWVQLVVVSLVRFSEPIAFSSLFPYVYFMVRDFNIapNDAQVskysGYLSSSFALCQVISAYHWG 80
Cdd:COG2807   1 MSTTSSSARRSRRAGRWLLLLAIVLVALNLRPAITSVGPLLPEIRADLGL--SATQA----GLLTTLPLLAFGLFAPLAP 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10383787  81 RFSEKHGRKITLTCGLIGTSVSLLILGFSRNFYQALVARSLMGL--LNGNVgVIRTIIGEIATERKHQALAFSTMPLlfQ 158
Cdd:COG2807  75 RLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAgiAVGNV-LLPGLIKRWFPDRVGLMTGLYTAAM--G 151

                       170
                ....*....|....
gi 10383787 159 FGAVVGPMIGGFLV 172
Cdd:COG2807 152 LGAALAAGLTVPLA 165
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 2-170 9.03e-03

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 38.69  E-value: 9.03e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10383787   2 ARQKLTFKEQMDGFPWVQLVVVSLVRFSEPIAFSSLFPyVYFMVRDFNIApndaqvskYSGYLSSSFALCQVISAYHWGR 81
Cdd:cd17478 182 AKSSARSTLKGVWRALLLLLIIVFLRSWVLSSLTTFLP-FYLVQRGYSLV--------FAGLLLSLFLFAGAIGTLIGGP 252

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10383787  82 FSEKHGRKITLTCGLIGTSVSLLILGFSRNFYQALVArSLMG-LLNGNVGVIRTIIGEIAteRKHQALAFS-TMPLLFQF 159
Cdd:cd17478 253 LSDRFGRRRVIIASLLLAAPFLLLFLLTPGIWSYILL-VLAGfLLFASFPVTVVLAQELL--PGNVGLASGlMMGLSFGL 329

                       170
                ....*....|.
gi 10383787 160 GAVVGPMIGGF 170
Cdd:cd17478 330 GGIGAPVLGAL 340
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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