Fin1p [Saccharomyces cerevisiae S288C]
Protein Classification
FIN1 domain-containing protein( domain architecture ID 13879656)
FIN1 domain-containing protein
List of domain hits
| Name | Accession | Description | Interval | E-value | |||||
| FIN1 | pfam17300 | Filaments in between nuclei protein-1; Fin1 is a kinetochore protein, predicted to contain two ... |
15-283 | 3.58e-67 | |||||
Filaments in between nuclei protein-1; Fin1 is a kinetochore protein, predicted to contain two putative coiled-coil regions at its C terminus. It is present in a filamentous structure associated with the spindle and spindle pole in dividing cells during anaphase. Fin1 is a substrate of S-phase cyclin-dependent kinase (CDK). It binds to PP1 creating the Fin1- PPI complex which is recruited onto kinetochores promoting spindle assembly checkpoint (SAC) dis-assembly during anaphase. This is an important step in cell division since the kinetochore is the docking site for the spindle assembly checkpoint that monitors the defects in chromosome attachment and blocks anaphase onset. Fin1 has two RXXS/T sequences: S377 (RVTS), S526 (RKVS) that can be phosphorylated. Upon phosphorylation, interactions with other proteins such as Bmh1 and Bmh2 is promoted. However, de-phosphorylation during anaphase promotes the kinetochore recruitment of Fin1-PP1. : Pssm-ID: 407411 Cd Length: 240 Bit Score: 209.26 E-value: 3.58e-67
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| Name | Accession | Description | Interval | E-value | |||||
| FIN1 | pfam17300 | Filaments in between nuclei protein-1; Fin1 is a kinetochore protein, predicted to contain two ... |
15-283 | 3.58e-67 | |||||
Filaments in between nuclei protein-1; Fin1 is a kinetochore protein, predicted to contain two putative coiled-coil regions at its C terminus. It is present in a filamentous structure associated with the spindle and spindle pole in dividing cells during anaphase. Fin1 is a substrate of S-phase cyclin-dependent kinase (CDK). It binds to PP1 creating the Fin1- PPI complex which is recruited onto kinetochores promoting spindle assembly checkpoint (SAC) dis-assembly during anaphase. This is an important step in cell division since the kinetochore is the docking site for the spindle assembly checkpoint that monitors the defects in chromosome attachment and blocks anaphase onset. Fin1 has two RXXS/T sequences: S377 (RVTS), S526 (RKVS) that can be phosphorylated. Upon phosphorylation, interactions with other proteins such as Bmh1 and Bmh2 is promoted. However, de-phosphorylation during anaphase promotes the kinetochore recruitment of Fin1-PP1. Pssm-ID: 407411 Cd Length: 240 Bit Score: 209.26 E-value: 3.58e-67
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| Name | Accession | Description | Interval | E-value | |||||
| FIN1 | pfam17300 | Filaments in between nuclei protein-1; Fin1 is a kinetochore protein, predicted to contain two ... |
15-283 | 3.58e-67 | |||||
Filaments in between nuclei protein-1; Fin1 is a kinetochore protein, predicted to contain two putative coiled-coil regions at its C terminus. It is present in a filamentous structure associated with the spindle and spindle pole in dividing cells during anaphase. Fin1 is a substrate of S-phase cyclin-dependent kinase (CDK). It binds to PP1 creating the Fin1- PPI complex which is recruited onto kinetochores promoting spindle assembly checkpoint (SAC) dis-assembly during anaphase. This is an important step in cell division since the kinetochore is the docking site for the spindle assembly checkpoint that monitors the defects in chromosome attachment and blocks anaphase onset. Fin1 has two RXXS/T sequences: S377 (RVTS), S526 (RKVS) that can be phosphorylated. Upon phosphorylation, interactions with other proteins such as Bmh1 and Bmh2 is promoted. However, de-phosphorylation during anaphase promotes the kinetochore recruitment of Fin1-PP1. Pssm-ID: 407411 Cd Length: 240 Bit Score: 209.26 E-value: 3.58e-67
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| Blast search parameters | ||||
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