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Conserved domains on  [gi|398365941|ref|NP_010454|]
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Arf family guanine nucleotide exchange factor SEC7 [Saccharomyces cerevisiae S288C]

Protein Classification

ARF family guanine-nucleotide exchange factor( domain architecture ID 1001583)

ARF family guanine-nucleotide exchange factor activates ARF proteins by exchanging bound GDP for free GTP

Gene Ontology:  GO:0032012|GO:0015031
PubMed:  11752622

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PLN03076 super family cl33628
ARF guanine nucleotide exchange factor (ARF-GEF); Provisional
 272-1935 0e+00

ARF guanine nucleotide exchange factor (ARF-GEF); Provisional


The actual alignment was detected with superfamily member PLN03076:

Pssm-ID: 215560 [Multi-domain]  Cd Length: 1780  Bit Score: 685.40  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365941  272 DSILVFEALRASCRTKSSKVQSLALDCLSKLfsfrsldetllvnppdsLASNDQRQDAADgiTPPPKQKIIDAAIDTISD 351
Cdd:PLN03076   83 ESELILSPLINACGTGSAKIVDPALDCIQKL-----------------IAHGYLRGEADP--SGGPEALLLAKLIESVCK 143

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365941  352 CFqgEGTDDRVELQIVRALSSCIleeDSSSL-CHGASLLKAIRTIYNVFVFSLNPSNQGIAQATLTQIISSVYDKIDLKQ 430
Cdd:PLN03076  144 CH--DLGDEGIELLVLKTLLSAV---TSTSLrIHGDCLLQAVRTCYDIYLGSKNVVNQTTAKASLIQMLVIVFRRMEADS 218

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365941  431 ST----------------SSAVSLSTKNHQQQSAIELSEASENAETPAPLTLENM--------------------DKLND 474
Cdd:PLN03076  219 STvpiqpivvaelmepaeKSDSDTSMTQFVQGFITKIMQDIDGVLNPATAGKSSGsgahdgafettatvettnpaDLLDS 298

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365941  475 DEERLMDA-----------------QQPDSIAITNQDLAV-------KDAFLVFRVMAKICAKPLETELDMRSHAVRSKL 530
Cdd:PLN03076  299 TDKDMLDAkyweismyksalegrkgELADGEVEKDDDLEVqignklrRDAFLVFRALCKLSMKTPPKEALADPQLMRGKI 378

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365941  531 LSLHIIYSIIKDHIDVFLShniflpgKERvcFIDSIRQYLRLVLSRNAASPLAPVFEVTLEIMWLLIANLRADFVKEIPV 610
Cdd:PLN03076  379 LALELLKILLENAGAVFRT-------SDR--FLGAIKQYLCLSLLKNSASSLMIIFQLSCSIFISLVSRFRAGLKAEIGV 449

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365941  611 FLTEIYFPISE-LTTSTSQQKRYFLSVIQRICNDPRTLVEFYLNYDCNPGMPNVMEITVDYLTRLALTRVEITQTqrsyy 689
Cdd:PLN03076  450 FFPMIVLRVLEnVAQPNFQQKMIVLRFLDKLCVDSQILVDIFINYDCDVNSSNIFERMVNGLLKTAQGVPPGVET----- 524

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365941  690 deqiskslstynfsqlplltssnlssspdvgqvNLLFPLDFALKMVSLNCIVSVLRSLSSWAHKALN-PNTHTANKvlln 768
Cdd:PLN03076  525 ---------------------------------TLLPPQEAAMKLEAMKCLVAILRSMGDWMNKQLRlPDPASLKK---- 567

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365941  769 ttSSARQESRSSlsndvrSSIMTSNDDFKPTYEDEESRSLSSQniDADDPTQFENLKLRKTALSECIAIFNNKPKKAIPV 848
Cdd:PLN03076  568 --LDAVENNLEP------GSLPVANGNGDENGEGSDSHSELSS--ETSDAATIEQRRAYKLELQEGISLFNRKPKKGIEF 637

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365941  849 LIKKGFLkDDSPISIAKWLLETEGLDMAAVGDYLGEGDDKNIAIMHAFVDEFDFTGMSIVDALRSFLQSFRLPGEGQKID 928
Cdd:PLN03076  638 LINANKV-GESPEEIAAFLKDASGLNKTLIGDYLGEREDLSLKVMHAYVDSFDFQGMEFDEAIRAFLQGFRLPGEAQKID 716

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365941  929 RFMLKFAERFVDQNPGVFSKADTAYVLSYSLIMLNTDLHSSQIKNKMSLQEFLENNEGIDNGRDLPRDFLEGLFNEIANN 1008
Cdd:PLN03076  717 RIMEKFAERYCKCNPKAFSSADTAYVLAYSVIMLNTDAHNPMVKNKMSADDFIRNNRGIDDGKDLPEEFMRSLYERISKN 796

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365941 1009 EIK-----LISEQHQA-----MLSGDTNL---VQQQQSAFNFFNSRDLTREAYNQVsKEISSKTElvfknlnknkggpDV 1075
Cdd:PLN03076  797 EIKmkeddLVPQQKQSansnrILGLDSILnivIRKRGEDSYMETSDDLIKHMQEQF-KEKARKSE-------------SV 862

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365941 1076 YYAASHVEHVKSIFETLWMSFLAALTPPFKDYDDIDTTNKCLEGLKISIKIASTFRINDARTSFVGALVQFCNLQNLEEI 1155
Cdd:PLN03076  863 YYAATDVVILRFMVEVCWAPMLAAFSVPLDQSDDEVVTFQCLEGFRHAIHVTAVMSMKTHRDAFVTSLAKFTSLHSPADI 942

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365941 1156 KVKNVNAMVILLEVALSEGNYLEGSWKDILLVVSQMERLQLISKGIDRDTV------PDVAQARVANP------------ 1217
Cdd:PLN03076  943 KQKNIDAIKAIVSIADEDGNYLQEAWEHILTCVSRFEHLHLLGEGAPPDATffaapqNESDKSKQAKSpilpvlkrkgpg 1022

                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365941 1218 RVSYESSRSNNTSF--FDVWGKKAtpTELAQEKHHNQTLSPEISKFISSSElvvlMDNIFTKSSELSGNAIVDFIKALTA 1295
Cdd:PLN03076 1023 KLQYAAAAVRRGSYdsAGVGGKAS--GVVTSEQMNNLVSNLNMLEQVGSFE----MNRIFTRSQKLNSEAIIDFVKALCK 1096

                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365941 1296 VSLEEIESsenASTPRMFSLQKMVDVCYYNMDRIKLEWTPLWAVMGKAFNKIATNSNLAVVFFAIDSLRQLSMRFLDIEE 1375
Cdd:PLN03076 1097 VSMEELRS---PSDPRVFSLTKIVEIAHYNMNRIRLVWSSIWHVLSDFFVTIGCSENLSIAIFAMDSLRQLSMKFLEREE 1173

                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365941 1376 LSGFEFQHDFLKPFEYTVQNSGNTEVQEMIIECFRNFILTKSESIKSGWKPILESLQYTARSSTESIVLKTQLLVSNdIV 1455
Cdd:PLN03076 1174 LANYNFQNEFMKPFVIVMRKSNAVEIRELIIRCVSQMVLSRVNNVKSGWKSMFMVFTTAAYDDHKNIVLLAFEIIEK-II 1252

                        1290      1300      1310      1320      1330      1340      1350      1360
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365941 1456 TNHFENVFSQED-AFSELVGVFREITkNKRFQK-LSLHALESLRKMTQNVA--DICFYNENKTEE----------ERKHN 1521
Cdd:PLN03076 1253 REYFPYITETETtTFTDCVNCLIAFT-NSRFNKdISLNAIAFLRFCATKLAegDLGSSSRNKDKEappsspqsgkDGKQE 1331

                        1370      1380      1390      1400      1410      1420      1430      1440
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365941 1522 DALLRGKDIFQDVWFPMLFCFNDTIMTAEDlEVRSRALNYMFDALVAYGGKFNDDFWEKICKKLLFPIF----------- 1590
Cdd:PLN03076 1332 SGEFTDKDDHLYFWFPLLAGLSELSFDPRP-EIRKSALQVLFDTLRNHGHLFSLPLWERVFESVLFPIFdyvrhaidpsg 1410

                        1450      1460      1470      1480      1490      1500      1510      1520
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365941 1591 GVLSKHWEVNQFNSHDDLSVWLSTTLIQALRNLIALFTHYFESLNRMLDGFLGLLVSCICQENDTIARIGRSCLQQLILQ 1670
Cdd:PLN03076 1411 GDEPEGQGVDGDQGELDQDAWLYETCTLALQLVVDLFVKFYPTVNPLLKKVLMLLVSFIKRPHQSLAGIGIAAFVRLMSN 1490

                        1530      1540      1550      1560      1570      1580      1590      1600
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365941 1671 NVSKFNEYHWNQIgdvfdklfdlttanelfdydplqqgrksSVSHHQTTNDTSqhsdddsndrrendsnisetverahqE 1750
Cdd:PLN03076 1491 AGHLFSDEKWLEV----------------------------VLSLKEAANATL--------------------------P 1516

                        1610      1620      1630      1640      1650      1660      1670      1680
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365941 1751 ESSEDVGGDMVETLNGQTKlNNGNSVPTvkdelnpkpaslsipkktkhmKRNESNEDIRRRINIKNSIV-VKC--VLQLL 1827
Cdd:PLN03076 1517 DFSYVVSGEYMPAENIQDS-ENAEAASS---------------------STADNDAEAERSRRLYAAISdAKCraAVQLL 1574

                        1690      1700      1710      1720      1730      1740      1750      1760
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365941 1828 MIELLNELFENEDfahciPYKEAIRITRLLEKSYEF---SRDFNEDYGLRTRLVEARVVDKI--PNLLKQETSAAAVLLD 1902
Cdd:PLN03076 1575 LIQAVMEIYNMYR-----PRLSAKNTLVLFDALHTVashAHKINSDTALRSKLQELGSMTQMqdPPLLRLENESYQICLT 1649

                        1770      1780      1790
                  ....*....|....*....|....*....|....*
gi 398365941 1903 IMFQLYLN--DDEKKADLITRLITICIQVVEGYVS 1935
Cdd:PLN03076 1650 FLQNLILDkpPLAKEAEVESRLVELCEEVLQFYIE 1684
 
Name Accession Description Interval E-value
PLN03076 PLN03076
ARF guanine nucleotide exchange factor (ARF-GEF); Provisional
 272-1935 0e+00

ARF guanine nucleotide exchange factor (ARF-GEF); Provisional


Pssm-ID: 215560 [Multi-domain]  Cd Length: 1780  Bit Score: 685.40  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365941  272 DSILVFEALRASCRTKSSKVQSLALDCLSKLfsfrsldetllvnppdsLASNDQRQDAADgiTPPPKQKIIDAAIDTISD 351
Cdd:PLN03076   83 ESELILSPLINACGTGSAKIVDPALDCIQKL-----------------IAHGYLRGEADP--SGGPEALLLAKLIESVCK 143

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365941  352 CFqgEGTDDRVELQIVRALSSCIleeDSSSL-CHGASLLKAIRTIYNVFVFSLNPSNQGIAQATLTQIISSVYDKIDLKQ 430
Cdd:PLN03076  144 CH--DLGDEGIELLVLKTLLSAV---TSTSLrIHGDCLLQAVRTCYDIYLGSKNVVNQTTAKASLIQMLVIVFRRMEADS 218

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365941  431 ST----------------SSAVSLSTKNHQQQSAIELSEASENAETPAPLTLENM--------------------DKLND 474
Cdd:PLN03076  219 STvpiqpivvaelmepaeKSDSDTSMTQFVQGFITKIMQDIDGVLNPATAGKSSGsgahdgafettatvettnpaDLLDS 298

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365941  475 DEERLMDA-----------------QQPDSIAITNQDLAV-------KDAFLVFRVMAKICAKPLETELDMRSHAVRSKL 530
Cdd:PLN03076  299 TDKDMLDAkyweismyksalegrkgELADGEVEKDDDLEVqignklrRDAFLVFRALCKLSMKTPPKEALADPQLMRGKI 378

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365941  531 LSLHIIYSIIKDHIDVFLShniflpgKERvcFIDSIRQYLRLVLSRNAASPLAPVFEVTLEIMWLLIANLRADFVKEIPV 610
Cdd:PLN03076  379 LALELLKILLENAGAVFRT-------SDR--FLGAIKQYLCLSLLKNSASSLMIIFQLSCSIFISLVSRFRAGLKAEIGV 449

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365941  611 FLTEIYFPISE-LTTSTSQQKRYFLSVIQRICNDPRTLVEFYLNYDCNPGMPNVMEITVDYLTRLALTRVEITQTqrsyy 689
Cdd:PLN03076  450 FFPMIVLRVLEnVAQPNFQQKMIVLRFLDKLCVDSQILVDIFINYDCDVNSSNIFERMVNGLLKTAQGVPPGVET----- 524

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365941  690 deqiskslstynfsqlplltssnlssspdvgqvNLLFPLDFALKMVSLNCIVSVLRSLSSWAHKALN-PNTHTANKvlln 768
Cdd:PLN03076  525 ---------------------------------TLLPPQEAAMKLEAMKCLVAILRSMGDWMNKQLRlPDPASLKK---- 567

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365941  769 ttSSARQESRSSlsndvrSSIMTSNDDFKPTYEDEESRSLSSQniDADDPTQFENLKLRKTALSECIAIFNNKPKKAIPV 848
Cdd:PLN03076  568 --LDAVENNLEP------GSLPVANGNGDENGEGSDSHSELSS--ETSDAATIEQRRAYKLELQEGISLFNRKPKKGIEF 637

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365941  849 LIKKGFLkDDSPISIAKWLLETEGLDMAAVGDYLGEGDDKNIAIMHAFVDEFDFTGMSIVDALRSFLQSFRLPGEGQKID 928
Cdd:PLN03076  638 LINANKV-GESPEEIAAFLKDASGLNKTLIGDYLGEREDLSLKVMHAYVDSFDFQGMEFDEAIRAFLQGFRLPGEAQKID 716

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365941  929 RFMLKFAERFVDQNPGVFSKADTAYVLSYSLIMLNTDLHSSQIKNKMSLQEFLENNEGIDNGRDLPRDFLEGLFNEIANN 1008
Cdd:PLN03076  717 RIMEKFAERYCKCNPKAFSSADTAYVLAYSVIMLNTDAHNPMVKNKMSADDFIRNNRGIDDGKDLPEEFMRSLYERISKN 796

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365941 1009 EIK-----LISEQHQA-----MLSGDTNL---VQQQQSAFNFFNSRDLTREAYNQVsKEISSKTElvfknlnknkggpDV 1075
Cdd:PLN03076  797 EIKmkeddLVPQQKQSansnrILGLDSILnivIRKRGEDSYMETSDDLIKHMQEQF-KEKARKSE-------------SV 862

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365941 1076 YYAASHVEHVKSIFETLWMSFLAALTPPFKDYDDIDTTNKCLEGLKISIKIASTFRINDARTSFVGALVQFCNLQNLEEI 1155
Cdd:PLN03076  863 YYAATDVVILRFMVEVCWAPMLAAFSVPLDQSDDEVVTFQCLEGFRHAIHVTAVMSMKTHRDAFVTSLAKFTSLHSPADI 942

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365941 1156 KVKNVNAMVILLEVALSEGNYLEGSWKDILLVVSQMERLQLISKGIDRDTV------PDVAQARVANP------------ 1217
Cdd:PLN03076  943 KQKNIDAIKAIVSIADEDGNYLQEAWEHILTCVSRFEHLHLLGEGAPPDATffaapqNESDKSKQAKSpilpvlkrkgpg 1022

                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365941 1218 RVSYESSRSNNTSF--FDVWGKKAtpTELAQEKHHNQTLSPEISKFISSSElvvlMDNIFTKSSELSGNAIVDFIKALTA 1295
Cdd:PLN03076 1023 KLQYAAAAVRRGSYdsAGVGGKAS--GVVTSEQMNNLVSNLNMLEQVGSFE----MNRIFTRSQKLNSEAIIDFVKALCK 1096

                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365941 1296 VSLEEIESsenASTPRMFSLQKMVDVCYYNMDRIKLEWTPLWAVMGKAFNKIATNSNLAVVFFAIDSLRQLSMRFLDIEE 1375
Cdd:PLN03076 1097 VSMEELRS---PSDPRVFSLTKIVEIAHYNMNRIRLVWSSIWHVLSDFFVTIGCSENLSIAIFAMDSLRQLSMKFLEREE 1173

                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365941 1376 LSGFEFQHDFLKPFEYTVQNSGNTEVQEMIIECFRNFILTKSESIKSGWKPILESLQYTARSSTESIVLKTQLLVSNdIV 1455
Cdd:PLN03076 1174 LANYNFQNEFMKPFVIVMRKSNAVEIRELIIRCVSQMVLSRVNNVKSGWKSMFMVFTTAAYDDHKNIVLLAFEIIEK-II 1252

                        1290      1300      1310      1320      1330      1340      1350      1360
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365941 1456 TNHFENVFSQED-AFSELVGVFREITkNKRFQK-LSLHALESLRKMTQNVA--DICFYNENKTEE----------ERKHN 1521
Cdd:PLN03076 1253 REYFPYITETETtTFTDCVNCLIAFT-NSRFNKdISLNAIAFLRFCATKLAegDLGSSSRNKDKEappsspqsgkDGKQE 1331

                        1370      1380      1390      1400      1410      1420      1430      1440
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365941 1522 DALLRGKDIFQDVWFPMLFCFNDTIMTAEDlEVRSRALNYMFDALVAYGGKFNDDFWEKICKKLLFPIF----------- 1590
Cdd:PLN03076 1332 SGEFTDKDDHLYFWFPLLAGLSELSFDPRP-EIRKSALQVLFDTLRNHGHLFSLPLWERVFESVLFPIFdyvrhaidpsg 1410

                        1450      1460      1470      1480      1490      1500      1510      1520
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365941 1591 GVLSKHWEVNQFNSHDDLSVWLSTTLIQALRNLIALFTHYFESLNRMLDGFLGLLVSCICQENDTIARIGRSCLQQLILQ 1670
Cdd:PLN03076 1411 GDEPEGQGVDGDQGELDQDAWLYETCTLALQLVVDLFVKFYPTVNPLLKKVLMLLVSFIKRPHQSLAGIGIAAFVRLMSN 1490

                        1530      1540      1550      1560      1570      1580      1590      1600
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365941 1671 NVSKFNEYHWNQIgdvfdklfdlttanelfdydplqqgrksSVSHHQTTNDTSqhsdddsndrrendsnisetverahqE 1750
Cdd:PLN03076 1491 AGHLFSDEKWLEV----------------------------VLSLKEAANATL--------------------------P 1516

                        1610      1620      1630      1640      1650      1660      1670      1680
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365941 1751 ESSEDVGGDMVETLNGQTKlNNGNSVPTvkdelnpkpaslsipkktkhmKRNESNEDIRRRINIKNSIV-VKC--VLQLL 1827
Cdd:PLN03076 1517 DFSYVVSGEYMPAENIQDS-ENAEAASS---------------------STADNDAEAERSRRLYAAISdAKCraAVQLL 1574

                        1690      1700      1710      1720      1730      1740      1750      1760
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365941 1828 MIELLNELFENEDfahciPYKEAIRITRLLEKSYEF---SRDFNEDYGLRTRLVEARVVDKI--PNLLKQETSAAAVLLD 1902
Cdd:PLN03076 1575 LIQAVMEIYNMYR-----PRLSAKNTLVLFDALHTVashAHKINSDTALRSKLQELGSMTQMqdPPLLRLENESYQICLT 1649

                        1770      1780      1790
                  ....*....|....*....|....*....|....*
gi 398365941 1903 IMFQLYLN--DDEKKADLITRLITICIQVVEGYVS 1935
Cdd:PLN03076 1650 FLQNLILDkpPLAKEAEVESRLVELCEEVLQFYIE 1684
Sec7 pfam01369
Sec7 domain; The Sec7 domain is a guanine-nucleotide-exchange-factor (GEF) for the pfam00025 ...
 827-1010 3.61e-94

Sec7 domain; The Sec7 domain is a guanine-nucleotide-exchange-factor (GEF) for the pfam00025 family.


Pssm-ID: 460178  Cd Length: 183  Bit Score: 302.07  E-value: 3.61e-94
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365941   827 RKTALSECIAIFNNKPKKAIPVLIKKGFLKDDsPISIAKWLLETEGLDMAAVGDYLGEGDDKNIAIMHAFVDEFDFTGMS 906
Cdd:pfam01369    1 RKKLLREGIEKFNKKPKKGIEYLIEKGFIEDD-PESIAKFLFETPGLDKKAIGEYLGKPDEFNIEVLKAFVDLFDFKGLR 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365941   907 IVDALRSFLQSFRLPGEGQKIDRFMLKFAERFVDQNPGVFSKADTAYVLSYSLIMLNTDLHSSQIKNKMSLQEFLENNEG 986
Cdd:pfam01369   80 IDEALRLFLESFRLPGEAQKIDRIMEAFAERYYEQNPGVFANADAAYVLAYSIIMLNTDLHNPNVKKKMTLEDFIRNLRG 159

                          170       180
                   ....*....|....*....|....
gi 398365941   987 IDNGRDLPRDFLEGLFNEIANNEI 1010
Cdd:pfam01369  160 INDGKDFPDEYLEEIYDSIKKNEI 183
Sec7 cd00171
Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the ...
 827-1010 2.53e-87

Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor activity.


Pssm-ID: 238100  Cd Length: 185  Bit Score: 282.57  E-value: 2.53e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365941  827 RKTALSECIAIFNNKPKKAIPVLIKKGFLKDDSPISIAKWLLETEGLDMAAVGDYLGEGDDKNIAIMHAFVDEFDFTGMS 906
Cdd:cd00171     1 RKTLLSEGRQLFNRKPKKGISFLIEKGFLEDDSPKEIAKFLYETEGLNKKAIGEYLGENNEFNSLVLHEFVDLFDFSGLR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365941  907 IVDALRSFLQSFRLPGEGQKIDRFMLKFAERFVDQNPGVFSK-ADTAYVLSYSLIMLNTDLHSSQIKNKMSLQEFLENNE 985
Cdd:cd00171    81 LDEALRKFLQSFRLPGEAQKIDRLLEKFSERYCECNPGIFSSsADAAYTLAYSIIMLNTDLHNPNVKKKMTLEDFIKNLR 160

                         170       180
                  ....*....|....*....|....*
gi 398365941  986 GIDNGRDLPRDFLEGLFNEIANNEI 1010
Cdd:cd00171   161 GINDGEDFPREFLKELYDSIKNNEI 185
Sec7 smart00222
Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product, which is required for ...
 824-1010 8.54e-80

Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product, which is required for proper protein transport through the Golgi. The domain facilitates guanine nucleotide exchange on the small GTPases, ARFs (ADP ribosylation factors).


Pssm-ID: 214569 [Multi-domain]  Cd Length: 189  Bit Score: 261.46  E-value: 8.54e-80
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365941    824 LKLRKTALSECIAIFNNKPKKAIPVLIKKGFLKDDSPISIAKWLLETEGLDMAAVGDYLGEGDDKNIAIMHAFVDEFDFT 903
Cdd:smart00222    1 SKGRKKLLSEGIVKFNDKPKKGIQSLQEKGFLANEDPQDVADFLSKNEGLNKKAIGDYLGEHDEFNRLVLHAFVDLFDFS 80

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365941    904 GMSIVDALRSFLQSFRLPGEGQKIDRFMLKFAERFVDQNPGVFSK--ADTAYVLSYSLIMLNTDLHSSQIKNKMSLQEFL 981
Cdd:smart00222   81 AKDLDQALREFLESFRLPGEAQKIDRLLEAFSSRYCECNPGVFSKanADAAYTLAYSLIMLNTDLHNPNVKKKMTLEDFI 160

                           170       180
                    ....*....|....*....|....*....
gi 398365941    982 ENNEGIDNGRDLPRDFLEGLFNEIANNEI 1010
Cdd:smart00222  161 KNVRGSNDGEDLPREFLEELYDSIKNNEI 189
 
Name Accession Description Interval E-value
PLN03076 PLN03076
ARF guanine nucleotide exchange factor (ARF-GEF); Provisional
 272-1935 0e+00

ARF guanine nucleotide exchange factor (ARF-GEF); Provisional


Pssm-ID: 215560 [Multi-domain]  Cd Length: 1780  Bit Score: 685.40  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365941  272 DSILVFEALRASCRTKSSKVQSLALDCLSKLfsfrsldetllvnppdsLASNDQRQDAADgiTPPPKQKIIDAAIDTISD 351
Cdd:PLN03076   83 ESELILSPLINACGTGSAKIVDPALDCIQKL-----------------IAHGYLRGEADP--SGGPEALLLAKLIESVCK 143

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365941  352 CFqgEGTDDRVELQIVRALSSCIleeDSSSL-CHGASLLKAIRTIYNVFVFSLNPSNQGIAQATLTQIISSVYDKIDLKQ 430
Cdd:PLN03076  144 CH--DLGDEGIELLVLKTLLSAV---TSTSLrIHGDCLLQAVRTCYDIYLGSKNVVNQTTAKASLIQMLVIVFRRMEADS 218

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365941  431 ST----------------SSAVSLSTKNHQQQSAIELSEASENAETPAPLTLENM--------------------DKLND 474
Cdd:PLN03076  219 STvpiqpivvaelmepaeKSDSDTSMTQFVQGFITKIMQDIDGVLNPATAGKSSGsgahdgafettatvettnpaDLLDS 298

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365941  475 DEERLMDA-----------------QQPDSIAITNQDLAV-------KDAFLVFRVMAKICAKPLETELDMRSHAVRSKL 530
Cdd:PLN03076  299 TDKDMLDAkyweismyksalegrkgELADGEVEKDDDLEVqignklrRDAFLVFRALCKLSMKTPPKEALADPQLMRGKI 378

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365941  531 LSLHIIYSIIKDHIDVFLShniflpgKERvcFIDSIRQYLRLVLSRNAASPLAPVFEVTLEIMWLLIANLRADFVKEIPV 610
Cdd:PLN03076  379 LALELLKILLENAGAVFRT-------SDR--FLGAIKQYLCLSLLKNSASSLMIIFQLSCSIFISLVSRFRAGLKAEIGV 449

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365941  611 FLTEIYFPISE-LTTSTSQQKRYFLSVIQRICNDPRTLVEFYLNYDCNPGMPNVMEITVDYLTRLALTRVEITQTqrsyy 689
Cdd:PLN03076  450 FFPMIVLRVLEnVAQPNFQQKMIVLRFLDKLCVDSQILVDIFINYDCDVNSSNIFERMVNGLLKTAQGVPPGVET----- 524

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365941  690 deqiskslstynfsqlplltssnlssspdvgqvNLLFPLDFALKMVSLNCIVSVLRSLSSWAHKALN-PNTHTANKvlln 768
Cdd:PLN03076  525 ---------------------------------TLLPPQEAAMKLEAMKCLVAILRSMGDWMNKQLRlPDPASLKK---- 567

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365941  769 ttSSARQESRSSlsndvrSSIMTSNDDFKPTYEDEESRSLSSQniDADDPTQFENLKLRKTALSECIAIFNNKPKKAIPV 848
Cdd:PLN03076  568 --LDAVENNLEP------GSLPVANGNGDENGEGSDSHSELSS--ETSDAATIEQRRAYKLELQEGISLFNRKPKKGIEF 637

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365941  849 LIKKGFLkDDSPISIAKWLLETEGLDMAAVGDYLGEGDDKNIAIMHAFVDEFDFTGMSIVDALRSFLQSFRLPGEGQKID 928
Cdd:PLN03076  638 LINANKV-GESPEEIAAFLKDASGLNKTLIGDYLGEREDLSLKVMHAYVDSFDFQGMEFDEAIRAFLQGFRLPGEAQKID 716

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365941  929 RFMLKFAERFVDQNPGVFSKADTAYVLSYSLIMLNTDLHSSQIKNKMSLQEFLENNEGIDNGRDLPRDFLEGLFNEIANN 1008
Cdd:PLN03076  717 RIMEKFAERYCKCNPKAFSSADTAYVLAYSVIMLNTDAHNPMVKNKMSADDFIRNNRGIDDGKDLPEEFMRSLYERISKN 796

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365941 1009 EIK-----LISEQHQA-----MLSGDTNL---VQQQQSAFNFFNSRDLTREAYNQVsKEISSKTElvfknlnknkggpDV 1075
Cdd:PLN03076  797 EIKmkeddLVPQQKQSansnrILGLDSILnivIRKRGEDSYMETSDDLIKHMQEQF-KEKARKSE-------------SV 862

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365941 1076 YYAASHVEHVKSIFETLWMSFLAALTPPFKDYDDIDTTNKCLEGLKISIKIASTFRINDARTSFVGALVQFCNLQNLEEI 1155
Cdd:PLN03076  863 YYAATDVVILRFMVEVCWAPMLAAFSVPLDQSDDEVVTFQCLEGFRHAIHVTAVMSMKTHRDAFVTSLAKFTSLHSPADI 942

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365941 1156 KVKNVNAMVILLEVALSEGNYLEGSWKDILLVVSQMERLQLISKGIDRDTV------PDVAQARVANP------------ 1217
Cdd:PLN03076  943 KQKNIDAIKAIVSIADEDGNYLQEAWEHILTCVSRFEHLHLLGEGAPPDATffaapqNESDKSKQAKSpilpvlkrkgpg 1022

                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365941 1218 RVSYESSRSNNTSF--FDVWGKKAtpTELAQEKHHNQTLSPEISKFISSSElvvlMDNIFTKSSELSGNAIVDFIKALTA 1295
Cdd:PLN03076 1023 KLQYAAAAVRRGSYdsAGVGGKAS--GVVTSEQMNNLVSNLNMLEQVGSFE----MNRIFTRSQKLNSEAIIDFVKALCK 1096

                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365941 1296 VSLEEIESsenASTPRMFSLQKMVDVCYYNMDRIKLEWTPLWAVMGKAFNKIATNSNLAVVFFAIDSLRQLSMRFLDIEE 1375
Cdd:PLN03076 1097 VSMEELRS---PSDPRVFSLTKIVEIAHYNMNRIRLVWSSIWHVLSDFFVTIGCSENLSIAIFAMDSLRQLSMKFLEREE 1173

                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365941 1376 LSGFEFQHDFLKPFEYTVQNSGNTEVQEMIIECFRNFILTKSESIKSGWKPILESLQYTARSSTESIVLKTQLLVSNdIV 1455
Cdd:PLN03076 1174 LANYNFQNEFMKPFVIVMRKSNAVEIRELIIRCVSQMVLSRVNNVKSGWKSMFMVFTTAAYDDHKNIVLLAFEIIEK-II 1252

                        1290      1300      1310      1320      1330      1340      1350      1360
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365941 1456 TNHFENVFSQED-AFSELVGVFREITkNKRFQK-LSLHALESLRKMTQNVA--DICFYNENKTEE----------ERKHN 1521
Cdd:PLN03076 1253 REYFPYITETETtTFTDCVNCLIAFT-NSRFNKdISLNAIAFLRFCATKLAegDLGSSSRNKDKEappsspqsgkDGKQE 1331

                        1370      1380      1390      1400      1410      1420      1430      1440
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365941 1522 DALLRGKDIFQDVWFPMLFCFNDTIMTAEDlEVRSRALNYMFDALVAYGGKFNDDFWEKICKKLLFPIF----------- 1590
Cdd:PLN03076 1332 SGEFTDKDDHLYFWFPLLAGLSELSFDPRP-EIRKSALQVLFDTLRNHGHLFSLPLWERVFESVLFPIFdyvrhaidpsg 1410

                        1450      1460      1470      1480      1490      1500      1510      1520
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365941 1591 GVLSKHWEVNQFNSHDDLSVWLSTTLIQALRNLIALFTHYFESLNRMLDGFLGLLVSCICQENDTIARIGRSCLQQLILQ 1670
Cdd:PLN03076 1411 GDEPEGQGVDGDQGELDQDAWLYETCTLALQLVVDLFVKFYPTVNPLLKKVLMLLVSFIKRPHQSLAGIGIAAFVRLMSN 1490

                        1530      1540      1550      1560      1570      1580      1590      1600
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365941 1671 NVSKFNEYHWNQIgdvfdklfdlttanelfdydplqqgrksSVSHHQTTNDTSqhsdddsndrrendsnisetverahqE 1750
Cdd:PLN03076 1491 AGHLFSDEKWLEV----------------------------VLSLKEAANATL--------------------------P 1516

                        1610      1620      1630      1640      1650      1660      1670      1680
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365941 1751 ESSEDVGGDMVETLNGQTKlNNGNSVPTvkdelnpkpaslsipkktkhmKRNESNEDIRRRINIKNSIV-VKC--VLQLL 1827
Cdd:PLN03076 1517 DFSYVVSGEYMPAENIQDS-ENAEAASS---------------------STADNDAEAERSRRLYAAISdAKCraAVQLL 1574

                        1690      1700      1710      1720      1730      1740      1750      1760
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365941 1828 MIELLNELFENEDfahciPYKEAIRITRLLEKSYEF---SRDFNEDYGLRTRLVEARVVDKI--PNLLKQETSAAAVLLD 1902
Cdd:PLN03076 1575 LIQAVMEIYNMYR-----PRLSAKNTLVLFDALHTVashAHKINSDTALRSKLQELGSMTQMqdPPLLRLENESYQICLT 1649

                        1770      1780      1790
                  ....*....|....*....|....*....|....*
gi 398365941 1903 IMFQLYLN--DDEKKADLITRLITICIQVVEGYVS 1935
Cdd:PLN03076 1650 FLQNLILDkpPLAKEAEVESRLVELCEEVLQFYIE 1684
Sec7 pfam01369
Sec7 domain; The Sec7 domain is a guanine-nucleotide-exchange-factor (GEF) for the pfam00025 ...
 827-1010 3.61e-94

Sec7 domain; The Sec7 domain is a guanine-nucleotide-exchange-factor (GEF) for the pfam00025 family.


Pssm-ID: 460178  Cd Length: 183  Bit Score: 302.07  E-value: 3.61e-94
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365941   827 RKTALSECIAIFNNKPKKAIPVLIKKGFLKDDsPISIAKWLLETEGLDMAAVGDYLGEGDDKNIAIMHAFVDEFDFTGMS 906
Cdd:pfam01369    1 RKKLLREGIEKFNKKPKKGIEYLIEKGFIEDD-PESIAKFLFETPGLDKKAIGEYLGKPDEFNIEVLKAFVDLFDFKGLR 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365941   907 IVDALRSFLQSFRLPGEGQKIDRFMLKFAERFVDQNPGVFSKADTAYVLSYSLIMLNTDLHSSQIKNKMSLQEFLENNEG 986
Cdd:pfam01369   80 IDEALRLFLESFRLPGEAQKIDRIMEAFAERYYEQNPGVFANADAAYVLAYSIIMLNTDLHNPNVKKKMTLEDFIRNLRG 159

                          170       180
                   ....*....|....*....|....
gi 398365941   987 IDNGRDLPRDFLEGLFNEIANNEI 1010
Cdd:pfam01369  160 INDGKDFPDEYLEEIYDSIKKNEI 183
Sec7 cd00171
Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the ...
 827-1010 2.53e-87

Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor activity.


Pssm-ID: 238100  Cd Length: 185  Bit Score: 282.57  E-value: 2.53e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365941  827 RKTALSECIAIFNNKPKKAIPVLIKKGFLKDDSPISIAKWLLETEGLDMAAVGDYLGEGDDKNIAIMHAFVDEFDFTGMS 906
Cdd:cd00171     1 RKTLLSEGRQLFNRKPKKGISFLIEKGFLEDDSPKEIAKFLYETEGLNKKAIGEYLGENNEFNSLVLHEFVDLFDFSGLR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365941  907 IVDALRSFLQSFRLPGEGQKIDRFMLKFAERFVDQNPGVFSK-ADTAYVLSYSLIMLNTDLHSSQIKNKMSLQEFLENNE 985
Cdd:cd00171    81 LDEALRKFLQSFRLPGEAQKIDRLLEKFSERYCECNPGIFSSsADAAYTLAYSIIMLNTDLHNPNVKKKMTLEDFIKNLR 160

                         170       180
                  ....*....|....*....|....*
gi 398365941  986 GIDNGRDLPRDFLEGLFNEIANNEI 1010
Cdd:cd00171   161 GINDGEDFPREFLKELYDSIKNNEI 185
Sec7 smart00222
Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product, which is required for ...
 824-1010 8.54e-80

Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product, which is required for proper protein transport through the Golgi. The domain facilitates guanine nucleotide exchange on the small GTPases, ARFs (ADP ribosylation factors).


Pssm-ID: 214569 [Multi-domain]  Cd Length: 189  Bit Score: 261.46  E-value: 8.54e-80
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365941    824 LKLRKTALSECIAIFNNKPKKAIPVLIKKGFLKDDSPISIAKWLLETEGLDMAAVGDYLGEGDDKNIAIMHAFVDEFDFT 903
Cdd:smart00222    1 SKGRKKLLSEGIVKFNDKPKKGIQSLQEKGFLANEDPQDVADFLSKNEGLNKKAIGDYLGEHDEFNRLVLHAFVDLFDFS 80

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365941    904 GMSIVDALRSFLQSFRLPGEGQKIDRFMLKFAERFVDQNPGVFSK--ADTAYVLSYSLIMLNTDLHSSQIKNKMSLQEFL 981
Cdd:smart00222   81 AKDLDQALREFLESFRLPGEAQKIDRLLEAFSSRYCECNPGVFSKanADAAYTLAYSLIMLNTDLHNPNVKKKMTLEDFI 160

                           170       180
                    ....*....|....*....|....*....
gi 398365941    982 ENNEGIDNGRDLPRDFLEGLFNEIANNEI 1010
Cdd:smart00222  161 KNVRGSNDGEDLPREFLEELYDSIKNNEI 189
BIG2_C pfam20252
BIG2 C-terminal domain; This presumed domain is found at the C-terminus of BIG2 the brefeldin ...
 1823-1999 6.13e-53

BIG2 C-terminal domain; This presumed domain is found at the C-terminus of BIG2 the brefeldin A-inhibited guanine nucleotide-exchange protein. The function of this region is unknown.


Pssm-ID: 466403  Cd Length: 178  Bit Score: 183.98  E-value: 6.13e-53
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365941  1823 VLQLLMIELLNELFEnEDFAHcIPYKEAIRITRLLEKSYEFSRDFNEDYGLRTRLVEARVVDKIPNLLKQETSAAAVLLD 1902
Cdd:pfam20252    1 VVQLLLIQTVNEILD-EHYES-LPSDHLLRLLDCLEKSYTFARSFNSDLELRTALWRAGFMKQLPNLLKQETSSLSTYLR 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365941  1903 IMFQLYLNDD---EKKADLITRLITICIQVVEGYVSLDDRTMERSINAWRSVIVEILQGYYEFDDEDFRLYCPAMYALVI 1979
Cdd:pfam20252   79 ILFRLYADDEprtSQREEVEERLIPLCEDILEYYLSLDEEEKQRELAAWTPVVVLILQGLLALPDDDFRRHLPEFYPLLC 158

                          170       180
                   ....*....|....*....|
gi 398365941  1980 QILDKSVPTELRHAIKQFLS 1999
Cdd:pfam20252  159 DLILCELSPEVRLALREFFS 178
Sec7_N pfam12783
Guanine nucleotide exchange factor in Golgi transport N-terminal; The full-length Sec7 ...
 496-659 1.36e-51

Guanine nucleotide exchange factor in Golgi transport N-terminal; The full-length Sec7 functions proximally in the secretory pathway as a protein binding scaffold for the coat protein complexes COPII-COPI. The COPII-COPI-protein switch is necessary for maturation of the vesicular-tubular cluster, VTC, intermediate compartments for Golgi compartment biogenesis. This N-terminal domain however does not appear to be binding either of the COP or the ARF.


Pssm-ID: 463703  Cd Length: 154  Bit Score: 178.84  E-value: 1.36e-51
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365941   496 AVKDAFLVFRVMAKICAKPLETELDMRSHAVRSKLLSLHIIYSIIKDHIDVFLSHNiflpgkervCFIDSIRQYLRLVLS 575
Cdd:pfam12783    1 AAKDAFLVFRDLCKLSNGKPLSKSDPKSHAERSKLFSLELIESILENHGDVFLKHP---------ELLQLLKQYLCPSLL 71

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365941   576 RNAASPLAPVFEVTLEIMWLLIANLRADFVKEIPVFLTEIYFPISElTTSTSQQKRYFLSVIQRICNDPRTLVEFYLNYD 655
Cdd:pfam12783   72 RNLSSSSFPVFVRSLRIFLLLLRRFRSHLKLEIEVFLSLLILPLLE-SDSSLWQKALVLEVLRRLCSDPQLLVEIYLNYD 150


                   ....
gi 398365941   656 CNPG 659
Cdd:pfam12783  151 CDLG 154
DUF1981 pfam09324
Domain of unknown function (DUF1981); Members of this family of functionally uncharacterized ...
 1369-1452 5.54e-32

Domain of unknown function (DUF1981); Members of this family of functionally uncharacterized domains are found in various plant and yeast protein transport proteins.


Pssm-ID: 462756  Cd Length: 84  Bit Score: 120.29  E-value: 5.54e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365941  1369 RFLDIEELSGFEFQHDFLKPFEYTVQNSGNTEVQEMIIECFRNFILTKSESIKSGWKPILESLQYTARSSTESIVLKTQL 1448
Cdd:pfam09324    1 KFLEKEELSNFKFQKDFLKPFEYIMSNNSSVDVKELVLECILQMIQSKGDNIKSGWKTIFGVLTAAAKDSNESLVRLAFQ 80


                   ....
gi 398365941  1449 LVSN 1452
Cdd:pfam09324   81 ILEL 84
DCB pfam16213
dimerization and cyclophilin-binding domain of Mon2; DCB is the N-terminal domain of Mon2- and ...
 241-426 3.11e-11

dimerization and cyclophilin-binding domain of Mon2; DCB is the N-terminal domain of Mon2- and GIG1-like proteins from metazoa. Mon2 and BIG1 like proteins play an important role in the cytoplasm-to-vacuole transport pathway and are required for Golgi homeostasis.


Pssm-ID: 465072 [Multi-domain]  Cd Length: 172  Bit Score: 63.81  E-value: 3.11e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365941   241 KKNSNAQKAIERTLQKFK---EFDPQTTNNPHYVDSILvfEALRASCRTKSSKVQSLALDCLSKLFSFRSLDetllvnpp 317
Cdd:pfam16213   22 RKYPPVKEASEKGILRLRtvhSSSPLMQNLLSASEDIL--KPFVLACETKNPKLVQIALGCLQKLISHDAIS-------- 91

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365941   318 dslasndqrQDAADGItpppkqkiidaaIDTISDCFQGeGTDdrVELQIvraLSSCILEEDSSSLCHGASLLKAIRTIYN 397
Cdd:pfam16213   92 ---------QSAAPYI------------LDTLWMLMEL-GSE--IELKV---LQTVLLLITTNSVIHGDTLAKALVLCFR 144

                          170       180
                   ....*....|....*....|....*....
gi 398365941   398 VfVFSLNPSNQGIAQATLTQIISSVYDKI 426
Cdd:pfam16213  145 L-HFSKDPTVQNTASATLRQLVSVVFERV 172
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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