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Conserved domains on  [gi|6320419|ref|NP_010499|]
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Upc2p [Saccharomyces cerevisiae S288C]

Protein Classification

Zn(II)2Cys6 transcription factor( domain architecture ID 11251378)

Zn(II)2Cys6 transcription factor domain-containing proteins form a subclass of zinc finger proteins found exclusively in fungi

Gene Ontology:  GO:0003677|GO:0008270|GO:0006351|GO:0003700
PubMed:  9290251|16959962

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GAL4 smart00066
GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster DNA-binding domain; Gal4 is a positive ...
 46-87 6.86e-14

GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster DNA-binding domain; Gal4 is a positive regulator for the gene expression of the galactose- induced genes of S. cerevisiae. Is present only in fungi.


:

Pssm-ID: 214501 [Multi-domain]  Cd Length: 43  Bit Score: 66.23  E-value: 6.86e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 6320419      46 KSKNGCDNCKRRRVKCDEGKPACRKCTNMKLECQYTPIHLRK 87
Cdd:smart00066   2 RVSKACDRCRKRKIKCDGKKPPCSNCIKLGLECTYSDSKKRK 43
fungal_TF_MHR super family cl23766
fungal transcription factor regulatory middle homology region; This domain is present in the ...
 612-753 7.85e-11

fungal transcription factor regulatory middle homology region; This domain is present in the large family of fungal zinc cluster transcription factors that contain an N-terminal GAL4-like C6 zinc binuclear cluster DNA-binding domain. Examples of members of this large fungal group are the following Saccharomyces cerevisiae transcription factors, GAL4, STB5, DAL81, CAT8, RDR1, HAL9, PUT3, PPR1, ASG1, RSF2, PIP2, as well as the C-terminal domain of the Cep3, a subunit of the yeast centromere-binding factor 3. It has been suggested that this region plays a regulatory role.


The actual alignment was detected with superfamily member pfam11951:

Pssm-ID: 419994  Cd Length: 384  Bit Score: 65.13  E-value: 7.85e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320419    612 LFHHYCTKVWPTIT-AAKVSGPeiWRDYIPELAFDYPFLMHALLAFSATHLSRT--ETGLEQYVSSHRLDALRLLREAVL 688
Cdd:pfam11951   2 LLDYYLDNVSPLLSpFPESSNP--FRKVLLPLALSNPALLHALLALSAFHLQSSgpPDLWEREAQRYKSLALRLLQRALA 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320419    689 EISENNT-----DALVASALILIMDSLAnasgNGTVGNqslnsmspsaWIFHVKGAATILTAVWPLSERS 753
Cdd:pfam11951  80 ELSSRLSsnskyDDVLAAILLLCSFEIS----SGDVSD----------WRVHLEGAKDLIRLRGGPSKTS 135
 
Name Accession Description Interval E-value
GAL4 smart00066
GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster DNA-binding domain; Gal4 is a positive ...
 46-87 6.86e-14

GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster DNA-binding domain; Gal4 is a positive regulator for the gene expression of the galactose- induced genes of S. cerevisiae. Is present only in fungi.


Pssm-ID: 214501 [Multi-domain]  Cd Length: 43  Bit Score: 66.23  E-value: 6.86e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 6320419      46 KSKNGCDNCKRRRVKCDEGKPACRKCTNMKLECQYTPIHLRK 87
Cdd:smart00066   2 RVSKACDRCRKRKIKCDGKKPPCSNCIKLGLECTYSDSKKRK 43
GAL4 cd00067
GAL4-like Zn2Cys6 binuclear cluster DNA-binding domain; found in transcription regulators like ...
 46-81 1.17e-12

GAL4-like Zn2Cys6 binuclear cluster DNA-binding domain; found in transcription regulators like GAL4. Domain consists of two helices organized around a Zn(2)Cys(6 )motif; Binds to sequences containing 2 DNA half sites comprised of 3-5 C/G combinations


Pssm-ID: 238023 [Multi-domain]  Cd Length: 36  Bit Score: 62.68  E-value: 1.17e-12
                        10        20        30
                ....*....|....*....|....*....|....*.
gi 6320419   46 KSKNGCDNCKRRRVKCDEGKPACRKCTNMKLECQYT 81
Cdd:cd00067   1 RVRRACDRCRRRKIKCDGEKPPCSNCIKLGLECTYS 36
Fungal_trans_2 pfam11951
Fungal specific transcription factor domain; This family of are likely to be transcription ...
 612-753 7.85e-11

Fungal specific transcription factor domain; This family of are likely to be transcription factors. This protein is found in fungi. Proteins in this family are typically between 454 to 826 amino acids in length. This protein is found associated with pfam00172.


Pssm-ID: 403235  Cd Length: 384  Bit Score: 65.13  E-value: 7.85e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320419    612 LFHHYCTKVWPTIT-AAKVSGPeiWRDYIPELAFDYPFLMHALLAFSATHLSRT--ETGLEQYVSSHRLDALRLLREAVL 688
Cdd:pfam11951   2 LLDYYLDNVSPLLSpFPESSNP--FRKVLLPLALSNPALLHALLALSAFHLQSSgpPDLWEREAQRYKSLALRLLQRALA 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320419    689 EISENNT-----DALVASALILIMDSLAnasgNGTVGNqslnsmspsaWIFHVKGAATILTAVWPLSERS 753
Cdd:pfam11951  80 ELSSRLSsnskyDDVLAAILLLCSFEIS----SGDVSD----------WRVHLEGAKDLIRLRGGPSKTS 135
Zn_clus pfam00172
Fungal Zn(2)-Cys(6) binuclear cluster domain;
50-82 2.65e-10

Fungal Zn(2)-Cys(6) binuclear cluster domain;


Pssm-ID: 395120 [Multi-domain]  Cd Length: 39  Bit Score: 56.15  E-value: 2.65e-10
                          10        20        30
                  ....*....|....*....|....*....|...
gi 6320419     50 GCDNCKRRRVKCDEGKPACRKCTNMKLECQYTP 82
Cdd:pfam00172   2 ACDNCRKRKVKCDGKKPACSRCIKNGLECTYSR 34
 
Name Accession Description Interval E-value
GAL4 smart00066
GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster DNA-binding domain; Gal4 is a positive ...
 46-87 6.86e-14

GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster DNA-binding domain; Gal4 is a positive regulator for the gene expression of the galactose- induced genes of S. cerevisiae. Is present only in fungi.


Pssm-ID: 214501 [Multi-domain]  Cd Length: 43  Bit Score: 66.23  E-value: 6.86e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 6320419      46 KSKNGCDNCKRRRVKCDEGKPACRKCTNMKLECQYTPIHLRK 87
Cdd:smart00066   2 RVSKACDRCRKRKIKCDGKKPPCSNCIKLGLECTYSDSKKRK 43
GAL4 cd00067
GAL4-like Zn2Cys6 binuclear cluster DNA-binding domain; found in transcription regulators like ...
 46-81 1.17e-12

GAL4-like Zn2Cys6 binuclear cluster DNA-binding domain; found in transcription regulators like GAL4. Domain consists of two helices organized around a Zn(2)Cys(6 )motif; Binds to sequences containing 2 DNA half sites comprised of 3-5 C/G combinations


Pssm-ID: 238023 [Multi-domain]  Cd Length: 36  Bit Score: 62.68  E-value: 1.17e-12
                        10        20        30
                ....*....|....*....|....*....|....*.
gi 6320419   46 KSKNGCDNCKRRRVKCDEGKPACRKCTNMKLECQYT 81
Cdd:cd00067   1 RVRRACDRCRRRKIKCDGEKPPCSNCIKLGLECTYS 36
Fungal_trans_2 pfam11951
Fungal specific transcription factor domain; This family of are likely to be transcription ...
 612-753 7.85e-11

Fungal specific transcription factor domain; This family of are likely to be transcription factors. This protein is found in fungi. Proteins in this family are typically between 454 to 826 amino acids in length. This protein is found associated with pfam00172.


Pssm-ID: 403235  Cd Length: 384  Bit Score: 65.13  E-value: 7.85e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320419    612 LFHHYCTKVWPTIT-AAKVSGPeiWRDYIPELAFDYPFLMHALLAFSATHLSRT--ETGLEQYVSSHRLDALRLLREAVL 688
Cdd:pfam11951   2 LLDYYLDNVSPLLSpFPESSNP--FRKVLLPLALSNPALLHALLALSAFHLQSSgpPDLWEREAQRYKSLALRLLQRALA 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320419    689 EISENNT-----DALVASALILIMDSLAnasgNGTVGNqslnsmspsaWIFHVKGAATILTAVWPLSERS 753
Cdd:pfam11951  80 ELSSRLSsnskyDDVLAAILLLCSFEIS----SGDVSD----------WRVHLEGAKDLIRLRGGPSKTS 135
Zn_clus pfam00172
Fungal Zn(2)-Cys(6) binuclear cluster domain;
50-82 2.65e-10

Fungal Zn(2)-Cys(6) binuclear cluster domain;


Pssm-ID: 395120 [Multi-domain]  Cd Length: 39  Bit Score: 56.15  E-value: 2.65e-10
                          10        20        30
                  ....*....|....*....|....*....|...
gi 6320419     50 GCDNCKRRRVKCDEGKPACRKCTNMKLECQYTP 82
Cdd:pfam00172   2 ACDNCRKRKVKCDGKKPACSRCIKNGLECTYSR 34
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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