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Conserved domains on  [gi|398366489|ref|NP_010611|]
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Utp4p [Saccharomyces cerevisiae S288C]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 12822048)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
43-356 3.35e-27

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 114.62  E-value: 3.35e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366489  43 PATITSLAFShksninkltPSDLRLAIGRSNGNIEIWNPRNNwfQEMVIEGGKDRSIEGLCWSNvNGEslRLFSIGGSTV 122
Cdd:COG2319  120 TGAVRSVAFS---------PDGKTLASGSADGTVRLWDLATG--KLLRTLTGHSGAVTSVAFSP-DGK--LLASGSDDGT 185

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366489 123 VTEWDLATGLPLRNYDCNSGVIWSISINDSQDKLSVGCDNGTVVLIDISGGPGVlehdTILMRQEARVLTLAWKKDD-FV 201
Cdd:COG2319  186 VRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLL----RTLTGHSGSVRSVAFSPDGrLL 261

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366489 202 IGGCSDGRIRIWSAQKndenmGRLLHTMKVDKAKkestlVWSVIYLPRTDQIASGDSTGSIKFWDFQFATLNQSFKAHDA 281
Cdd:COG2319  262 ASGSADGTVRLWDLAT-----GELLRTLTGHSGG-----VNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTG 331

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366489 282 DVLCLTTDTDNNYVFSAGVDRKIfqfsqntnksqknNRWVNSSNRLL-----HGNDIRAIcAYQSKGaDFLVSGGVEKTL 356
Cdd:COG2319  332 AVRSVAFSPDGKTLASGSDDGTV-------------RLWDLATGELLrtltgHTGAVTSV-AFSPDG-RTLASGSADGTV 396
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 272-443 1.37e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 47.71  E-value: 1.37e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366489 272 LNQSFKAHDADVLCLTTDTDNNYVFSAGVDRKIFQFSQNTNKSQKNN----------RWVNSSNRLL------------- 328
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLkghtgpvrdvAASADGTYLAsgssdktirlwdl 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366489 329 -----------HGNDIRAiCAYQSKGaDFLVSGGVEKTLVINSLTSFSNGnyRKMPTVEPYSKNVLVNKEQRLVV-SWSE 396
Cdd:cd00200   81 etgecvrtltgHTSYVSS-VAFSPDG-RILSSSSRDKTIKVWDVETGKCL--TTLRGHTDWVNSVAFSPDGTFVAsSSQD 156

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 398366489 397 STVKIWtmgtDSSTEQnyklvCKLTLKD-DQNISTCSLSPDGQVLVVG 443
Cdd:cd00200  157 GTIKLW----DLRTGK-----CVATLTGhTGEVNSVAFSPDGEKLLSS 195
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
43-356 3.35e-27

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 114.62  E-value: 3.35e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366489  43 PATITSLAFShksninkltPSDLRLAIGRSNGNIEIWNPRNNwfQEMVIEGGKDRSIEGLCWSNvNGEslRLFSIGGSTV 122
Cdd:COG2319  120 TGAVRSVAFS---------PDGKTLASGSADGTVRLWDLATG--KLLRTLTGHSGAVTSVAFSP-DGK--LLASGSDDGT 185

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366489 123 VTEWDLATGLPLRNYDCNSGVIWSISINDSQDKLSVGCDNGTVVLIDISGGPGVlehdTILMRQEARVLTLAWKKDD-FV 201
Cdd:COG2319  186 VRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLL----RTLTGHSGSVRSVAFSPDGrLL 261

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366489 202 IGGCSDGRIRIWSAQKndenmGRLLHTMKVDKAKkestlVWSVIYLPRTDQIASGDSTGSIKFWDFQFATLNQSFKAHDA 281
Cdd:COG2319  262 ASGSADGTVRLWDLAT-----GELLRTLTGHSGG-----VNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTG 331

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366489 282 DVLCLTTDTDNNYVFSAGVDRKIfqfsqntnksqknNRWVNSSNRLL-----HGNDIRAIcAYQSKGaDFLVSGGVEKTL 356
Cdd:COG2319  332 AVRSVAFSPDGKTLASGSDDGTV-------------RLWDLATGELLrtltgHTGAVTSV-AFSPDG-RTLASGSADGTV 396
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 53-304 7.69e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 93.55  E-value: 7.69e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366489  53 HKSNINKLT--PSDLRLAIGRSNGNIEIWNPRNNwfqEMVIE-GGKDRSIEGLCWSNvngeSLRLFSIGGS-TVVTEWDL 128
Cdd:cd00200   50 HTGPVRDVAasADGTYLASGSSDKTIRLWDLETG---ECVRTlTGHTSYVSSVAFSP----DGRILSSSSRdKTIKVWDV 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366489 129 ATGLPLRNYDCNSGVIWSISINDSQDKLSVGCDNGTVVLIDISGGPGVlehdTILMRQEARVLTLAWKKDDF-VIGGCSD 207
Cdd:cd00200  123 ETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCV----ATLTGHTGEVNSVAFSPDGEkLLSSSSD 198

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366489 208 GRIRIWsaqknDENMGRLLHTMKVDKAKkestlVWSVIYLPRTDQIASGDSTGSIKFWDFQFATLNQSFKAHDADVLCLT 287
Cdd:cd00200  199 GTIKLW-----DLSTGKCLGTLRGHENG-----VNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLA 268

                        250
                 ....*....|....*..
gi 398366489 288 TDTDNNYVFSAGVDRKI 304
Cdd:cd00200  269 WSPDGKRLASGSADGTI 285
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 272-443 1.37e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 47.71  E-value: 1.37e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366489 272 LNQSFKAHDADVLCLTTDTDNNYVFSAGVDRKIFQFSQNTNKSQKNN----------RWVNSSNRLL------------- 328
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLkghtgpvrdvAASADGTYLAsgssdktirlwdl 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366489 329 -----------HGNDIRAiCAYQSKGaDFLVSGGVEKTLVINSLTSFSNGnyRKMPTVEPYSKNVLVNKEQRLVV-SWSE 396
Cdd:cd00200   81 etgecvrtltgHTSYVSS-VAFSPDG-RILSSSSRDKTIKVWDVETGKCL--TTLRGHTDWVNSVAFSPDGTFVAsSSQD 156

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 398366489 397 STVKIWtmgtDSSTEQnyklvCKLTLKD-DQNISTCSLSPDGQVLVVG 443
Cdd:cd00200  157 GTIKLW----DLRTGK-----CVATLTGhTGEVNSVAFSPDGEKLLSS 195
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
43-356 3.35e-27

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 114.62  E-value: 3.35e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366489  43 PATITSLAFShksninkltPSDLRLAIGRSNGNIEIWNPRNNwfQEMVIEGGKDRSIEGLCWSNvNGEslRLFSIGGSTV 122
Cdd:COG2319  120 TGAVRSVAFS---------PDGKTLASGSADGTVRLWDLATG--KLLRTLTGHSGAVTSVAFSP-DGK--LLASGSDDGT 185

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366489 123 VTEWDLATGLPLRNYDCNSGVIWSISINDSQDKLSVGCDNGTVVLIDISGGPGVlehdTILMRQEARVLTLAWKKDD-FV 201
Cdd:COG2319  186 VRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLL----RTLTGHSGSVRSVAFSPDGrLL 261

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366489 202 IGGCSDGRIRIWSAQKndenmGRLLHTMKVDKAKkestlVWSVIYLPRTDQIASGDSTGSIKFWDFQFATLNQSFKAHDA 281
Cdd:COG2319  262 ASGSADGTVRLWDLAT-----GELLRTLTGHSGG-----VNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTG 331

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366489 282 DVLCLTTDTDNNYVFSAGVDRKIfqfsqntnksqknNRWVNSSNRLL-----HGNDIRAIcAYQSKGaDFLVSGGVEKTL 356
Cdd:COG2319  332 AVRSVAFSPDGKTLASGSDDGTV-------------RLWDLATGELLrtltgHTGAVTSV-AFSPDG-RTLASGSADGTV 396
WD40 COG2319
WD40 repeat [General function prediction only];
113-443 6.99e-25

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 107.69  E-value: 6.99e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366489 113 RLFSIGGSTVVTEWDLATGLPLRNYDCNSGVIWSISINDSQDKLSVGCDNGTVVLIDISGGPGVlehdTILMRQEARVLT 192
Cdd:COG2319   92 LLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLL----RTLTGHSGAVTS 167

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366489 193 LAWKKD-DFVIGGCSDGRIRIWSAQKndenmGRLLHTMKVDKAkkestLVWSVIYLPRTDQIASGDSTGSIKFWDFQFAT 271
Cdd:COG2319  168 VAFSPDgKLLASGSDDGTVRLWDLAT-----GKLLRTLTGHTG-----AVRSVAFSPDGKLLASGSADGTVRLWDLATGK 237

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366489 272 LNQSFKAHDADVLCLTTDTDNNYVFSAGVDRKIFQFSQNTNKSQknnrwvnssnRLL--HGNDIRAICAyqSKGADFLVS 349
Cdd:COG2319  238 LLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELL----------RTLtgHSGGVNSVAF--SPDGKLLAS 305

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366489 350 GGVEKTLVInsltsFSNGNYRKMPTVEPYSKNVLV----NKEQRLVVSWSESTVKIWtmgtDSSTEQnyklvCKLTLKDD 425
Cdd:COG2319  306 GSDDGTVRL-----WDLATGKLLRTLTGHTGAVRSvafsPDGKTLASGSDDGTVRLW----DLATGE-----LLRTLTGH 371

                        330
                 ....*....|....*....
gi 398366489 426 QN-ISTCSLSPDGQVLVVG 443
Cdd:COG2319  372 TGaVTSVAFSPDGRTLASG 390
WD40 COG2319
WD40 repeat [General function prediction only];
111-443 3.34e-21

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 96.90  E-value: 3.34e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366489 111 SLRLFSIGGSTVVTEWDLATGLPLRNYDCNSGVIWSISINDSQDKLSVGCDNGTVVLIDISGGpgvlEHDTILMRQEARV 190
Cdd:COG2319   48 GARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATG----LLLRTLTGHTGAV 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366489 191 LTLAWKKD-DFVIGGCSDGRIRIWSAQKndenmGRLLHTMKVDKAKkestlVWSVIYLPRTDQIASGDSTGSIKFWDFQF 269
Cdd:COG2319  124 RSVAFSPDgKTLASGSADGTVRLWDLAT-----GKLLRTLTGHSGA-----VTSVAFSPDGKLLASGSDDGTVRLWDLAT 193

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366489 270 ATLNQSFKAHDADVLCLTTDTDNNYVFSAGVDRKIFQFSQNTNKSQKNNRWvnssnrllHGNDIRAIcAYQSKGaDFLVS 349
Cdd:COG2319  194 GKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTG--------HSGSVRSV-AFSPDG-RLLAS 263

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366489 350 GGVEKTLVINSLTSFSNGNYRKMPTVEPYSknVLVNKEQRLVVSWSE-STVKIWTMGTdssteqnYKLVCKLTLKDDQnI 428
Cdd:COG2319  264 GSADGTVRLWDLATGELLRTLTGHSGGVNS--VAFSPDGKLLASGSDdGTVRLWDLAT-------GKLLRTLTGHTGA-V 333

                        330
                 ....*....|....*
gi 398366489 429 STCSLSPDGQVLVVG 443
Cdd:COG2319  334 RSVAFSPDGKTLASG 348
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 53-304 7.69e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 93.55  E-value: 7.69e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366489  53 HKSNINKLT--PSDLRLAIGRSNGNIEIWNPRNNwfqEMVIE-GGKDRSIEGLCWSNvngeSLRLFSIGGS-TVVTEWDL 128
Cdd:cd00200   50 HTGPVRDVAasADGTYLASGSSDKTIRLWDLETG---ECVRTlTGHTSYVSSVAFSP----DGRILSSSSRdKTIKVWDV 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366489 129 ATGLPLRNYDCNSGVIWSISINDSQDKLSVGCDNGTVVLIDISGGPGVlehdTILMRQEARVLTLAWKKDDF-VIGGCSD 207
Cdd:cd00200  123 ETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCV----ATLTGHTGEVNSVAFSPDGEkLLSSSSD 198

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366489 208 GRIRIWsaqknDENMGRLLHTMKVDKAKkestlVWSVIYLPRTDQIASGDSTGSIKFWDFQFATLNQSFKAHDADVLCLT 287
Cdd:cd00200  199 GTIKLW-----DLSTGKCLGTLRGHENG-----VNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLA 268

                        250
                 ....*....|....*..
gi 398366489 288 TDTDNNYVFSAGVDRKI 304
Cdd:cd00200  269 WSPDGKRLASGSADGTI 285
WD40 COG2319
WD40 repeat [General function prediction only];
43-266 2.21e-20

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 94.21  E-value: 2.21e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366489  43 PATITSLAFShksninkltPSDLRLAIGRSNGNIEIWNPRNNwfQEMVIEGGKDRSIEGLCWSNvNGEslRLFSIGGSTV 122
Cdd:COG2319  204 TGAVRSVAFS---------PDGKLLASGSADGTVRLWDLATG--KLLRTLTGHSGSVRSVAFSP-DGR--LLASGSADGT 269

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366489 123 VTEWDLATGLPLRNYDCNSGVIWSISINDSQDKLSVGCDNGTVVLIDISGGPGVLEHDtilmRQEARVLTLAWKKDD-FV 201
Cdd:COG2319  270 VRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLT----GHTGAVRSVAFSPDGkTL 345

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 398366489 202 IGGCSDGRIRIWSAQKndenmGRLLHTMKVDKAKkestlVWSVIYLPRTDQIASGDSTGSIKFWD 266
Cdd:COG2319  346 ASGSDDGTVRLWDLAT-----GELLRTLTGHTGA-----VTSVAFSPDGRTLASGSADGTVRLWD 400
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 141-443 4.31e-18

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 85.46  E-value: 4.31e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366489 141 SGVIWSISINDSQDKLSVGCDNGTVVLIDisggpgvLEHDTILMRQE------ARVLTLAWkkDDFVIGGCSDGRIRIWs 214
Cdd:cd00200    9 TGGVTCVAFSPDGKLLATGSGDGTIKVWD-------LETGELLRTLKghtgpvRDVAASAD--GTYLASGSSDKTIRLW- 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366489 215 aqknDENMGRLLHTMKVDKAKkestlVWSVIYLPRTDQIASGDSTGSIKFWDFQFATLNQSFKAHDADVLCLTTDTDNNY 294
Cdd:cd00200   79 ----DLETGECVRTLTGHTSY-----VSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTF 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366489 295 VFSAGVDRKIFQFSQNTNKSQKN----NRWVNSsnrllhgndiraiCAYQSKGADFLVSGG--------VEKTLVINSLT 362
Cdd:cd00200  150 VASSSQDGTIKLWDLRTGKCVATltghTGEVNS-------------VAFSPDGEKLLSSSSdgtiklwdLSTGKCLGTLR 216

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366489 363 SFSNGNYrkmptvepyskNVLVNKEQRLVVSWSE-STVKIWtmgtDSSTEQnyklvCKLTLKDDQN-ISTCSLSPDGQVL 440
Cdd:cd00200  217 GHENGVN-----------SVAFSPDGYLLASGSEdGTIRVW----DLRTGE-----CVQTLSGHTNsVTSLAWSPDGKRL 276


                 ...
gi 398366489 441 VVG 443
Cdd:cd00200  277 ASG 279
WD40 COG2319
WD40 repeat [General function prediction only];
46-216 1.63e-15

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 79.18  E-value: 1.63e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366489  46 ITSLAFShksninkltPSDLRLAIGRSNGNIEIWNPRNNwfQEMVIEGGKDRSIEGLCWSNvNGEslRLFSIGGSTVVTE 125
Cdd:COG2319  249 VRSVAFS---------PDGRLLASGSADGTVRLWDLATG--ELLRTLTGHSGGVNSVAFSP-DGK--LLASGSDDGTVRL 314

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366489 126 WDLATGLPLRNYDCNSGVIWSISINDSQDKLSVGCDNGTVVLIDISGGpgvlEHDTILMRQEARVLTLAWKKD-DFVIGG 204
Cdd:COG2319  315 WDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATG----ELLRTLTGHTGAVTSVAFSPDgRTLASG 390

                        170
                 ....*....|..
gi 398366489 205 CSDGRIRIWSAQ 216
Cdd:COG2319  391 SADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 46-266 3.45e-12

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 67.75  E-value: 3.45e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366489  46 ITSLAFSHKSNInkltpsdlrLAIGRSNGNIEIWNPRNnwFQEMVIEGGKDRSIEGLCWSnvnGESLRLFSIGGSTVVTE 125
Cdd:cd00200   96 VSSVAFSPDGRI---------LSSSSRDKTIKVWDVET--GKCLTTLRGHTDWVNSVAFS---PDGTFVASSSQDGTIKL 161

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366489 126 WDLATGLPLRNYDCNSGVIWSISINDSQDKLSVGCDNGTVVLIDISGGpgvlEHDTILMRQEARVLTLAWKKD-DFVIGG 204
Cdd:cd00200  162 WDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTG----KCLGTLRGHENGVNSVAFSPDgYLLASG 237

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 398366489 205 CSDGRIRIWsaqknDENMGRLLHTmkvdkAKKESTLVWSVIYLPRTDQIASGDSTGSIKFWD 266
Cdd:cd00200  238 SEDGTIRVW-----DLRTGECVQT-----LSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
198-504 1.02e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 61.47  E-value: 1.02e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366489 198 DDFVIGGCSDGRIRIWSAQKNDENMGRLLHTmkvdkakkesTLVWSVIYLPRTDQIASGDSTGSIKFWDFQFATLNQSFK 277
Cdd:COG2319   48 GARLAAGAGDLTLLLLDAAAGALLATLLGHT----------AAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLT 117

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366489 278 AHDADVLCLTTDTDNNYVFSAGVDRKIfqfsqntnksqknNRWVNSSNRLL-----HGNDIRAIcAYQSKGaDFLVSGGV 352
Cdd:COG2319  118 GHTGAVRSVAFSPDGKTLASGSADGTV-------------RLWDLATGKLLrtltgHSGAVTSV-AFSPDG-KLLASGSD 182

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366489 353 EKTLVinsLTSFSNGNYRKmpTVEPYSKNVL---VNKEQRLVVSWSE-STVKIWtmgtDSSTEQnyklvCKLTLKDDQN- 427
Cdd:COG2319  183 DGTVR---LWDLATGKLLR--TLTGHTGAVRsvaFSPDGKLLASGSAdGTVRLW----DLATGK-----LLRTLTGHSGs 248

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366489 428 ISTCSLSPDGQVLVVGRPSTTkvfhlqpvgnkLKVTKLDNDLLLRTSTKL------VKFIDNSKIVICSCEDD-VFIVDL 500
Cdd:COG2319  249 VRSVAFSPDGRLLASGSADGT-----------VRLWDLATGELLRTLTGHsggvnsVAFSPDGKLLASGSDDGtVRLWDL 317


                 ....
gi 398366489 501 ESEE 504
Cdd:COG2319  318 ATGK 321
WD40 COG2319
WD40 repeat [General function prediction only];
37-172 9.38e-07

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 51.84  E-value: 9.38e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366489  37 RFVDFTPATITSLAFShksninkltPSDLRLAIGRSNGNIEIWNPRNNwfQEMVIEGGKDRSIEGLCWSNvNGEslRLFS 116
Cdd:COG2319  282 RTLTGHSGGVNSVAFS---------PDGKLLASGSDDGTVRLWDLATG--KLLRTLTGHTGAVRSVAFSP-DGK--TLAS 347

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 398366489 117 IGGSTVVTEWDLATGLPLRNYDCNSGVIWSISINDSQDKLSVGCDNGTVVLIDISG 172
Cdd:COG2319  348 GSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 272-443 1.37e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 47.71  E-value: 1.37e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366489 272 LNQSFKAHDADVLCLTTDTDNNYVFSAGVDRKIFQFSQNTNKSQKNN----------RWVNSSNRLL------------- 328
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLkghtgpvrdvAASADGTYLAsgssdktirlwdl 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366489 329 -----------HGNDIRAiCAYQSKGaDFLVSGGVEKTLVINSLTSFSNGnyRKMPTVEPYSKNVLVNKEQRLVV-SWSE 396
Cdd:cd00200   81 etgecvrtltgHTSYVSS-VAFSPDG-RILSSSSRDKTIKVWDVETGKCL--TTLRGHTDWVNSVAFSPDGTFVAsSSQD 156

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 398366489 397 STVKIWtmgtDSSTEQnyklvCKLTLKD-DQNISTCSLSPDGQVLVVG 443
Cdd:cd00200  157 GTIKLW----DLRTGK-----CVATLTGhTGEVNSVAFSPDGEKLLSS 195
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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