|
Name |
Accession |
Description |
Interval |
E-value |
| DEXQc_SRCAP |
cd18003 |
DEXH/Q-box helicase domain of SRCAP; Snf2-related CBP activator (SRCAP, also known as SWR1 or ... |
696-932 |
4.42e-152 |
|
DEXH/Q-box helicase domain of SRCAP; Snf2-related CBP activator (SRCAP, also known as SWR1 or DOMO1) is the core catalytic component of the multiprotein chromatin-remodeling SRCAP complex, that is necessary for the incorporation of the histone variant H2A.Z into nucleosomes. SRCAP is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350761 [Multi-domain] Cd Length: 223 Bit Score: 461.05 E-value: 4.42e-152
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 696 LRTYQKQGLNWLASLYNNHTNGILADEMGLGKTIQTISLLAYLACEKENWGPHLIVVPTSVLLNWEMEFKRFAPGFKVLT 775
Cdd:cd18003 1 LREYQHIGLDWLATLYEKNLNGILADEMGLGKTIQTIALLAHLACEKGNWGPHLIVVPTSVMLNWEMEFKRWCPGFKILT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 776 YYGSPQQRKEKRKGWNKPDAFHVCIVSYQLVVQDQHSFKRKRWQYMVLDEAHNIKNFRSTRWQALLNFNTQRRLLLTGTP 855
Cdd:cd18003 81 YYGSAKERKLKRQGWMKPNSFHVCITSYQLVVQDHQVFKRKKWKYLILDEAHNIKNFKSQRWQTLLNFNTQRRLLLTGTP 160
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 6320541 856 LQNNLAELWSLLYFLMPqtvidgkkvSGFADLDAFQQWFGRPVDKIIETGQNfgqdkETKKTVAKLHQVLRPYLLRR 932
Cdd:cd18003 161 LQNSLMELWSLMHFLMP---------HIFQSHQEFKEWFSNPLTAMSEGSQE-----ENEELVRRLHKVLRPFLLRR 223
|
|
| HepA |
COG0553 |
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ... |
649-1393 |
1.49e-107 |
|
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];
Pssm-ID: 440319 [Multi-domain] Cd Length: 682 Bit Score: 357.61 E-value: 1.49e-107
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 649 ERAGDFVHTQNENRDDIKDVEEDAETKVQEEQLSVVDVPVPSLLRGNLRTYQKQGLNWLASLYNNHTNGILADEMGLGKT 728
Cdd:COG0553 195 LAAEAELLLLLELLLELELLAEAAVDAFRLRRLREALESLPAGLKATLRPYQLEGAAWLLFLRRLGLGGLLADDMGLGKT 274
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 729 IQTISLLAYLAcEKENWGPHLIVVPTSVLLNWEMEFKRFAPGFKVLTYYGsPQQRKEKRKGWNKPDafhVCIVSYQLVVQ 808
Cdd:COG0553 275 IQALALLLELK-ERGLARPVLIVAPTSLVGNWQRELAKFAPGLRVLVLDG-TRERAKGANPFEDAD---LVITSYGLLRR 349
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 809 DQHSFKRKRWQYMVLDEAHNIKNFRSTRWQALLNFNTQRRLLLTGTPLQNNLAELWSLLYFLMPQTvidgkkvsgFADLD 888
Cdd:COG0553 350 DIELLAAVDWDLVILDEAQHIKNPATKRAKAVRALKARHRLALTGTPVENRLEELWSLLDFLNPGL---------LGSLK 420
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 889 AFQQWFGRPVDKiietgqnfgqdkETKKTVAKLHQVLRPyllrrlkadvekqmpakyehivycklskrqrflyddfmsra 968
Cdd:COG0553 421 AFRERFARPIEK------------GDEEALERLRRLLRP----------------------------------------- 447
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 969 qtkatlasgnFMsivnclmqlrkvcnhpnlfevrpiltsfvlehcvasdykdvertllklfkknnqvnrvdldflnlvft 1048
Cdd:COG0553 448 ----------FL-------------------------------------------------------------------- 449
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 1049 lndkdltsyhaeeiskltcvknfveevnkLRETNKQLQEEFGEasflnfqdanqyfkysnkqklegtvdmlnflKMVNKL 1128
Cdd:COG0553 450 -----------------------------LRRTKEDVLKDLPE-------------------------------KTEETL 469
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 1129 RCDrrpifgknlidlLTKDRRVKYDKssiIDNELIKPLQTRVLDNRKIidtfavltpsaVSLDMRklalglnddssvgen 1208
Cdd:COG0553 470 YVE------------LTPEQRALYEA---VLEYLRRELEGAEGIRRRG-----------LILAAL--------------- 508
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 1209 TRLKvmQNCfevSNPLHQLQtkltiafpDKSLLQYDCGKLQKLAILLQQLKDNGHRALIFTQMTKVLDVLEQFLNYHGYL 1288
Cdd:COG0553 509 TRLR--QIC---SHPALLLE--------EGAELSGRSAKLEALLELLEELLAEGEKVLVFSQFTDTLDLLEERLEERGIE 575
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 1289 YMRLDGATKIEDRQILTERFNTDSRITVFILSSRSGGLGINLTGADTVIFYDSDWNPAMDKQCQDRCHRIGQTRDVHIYR 1368
Cdd:COG0553 576 YAYLHGGTSAEERDELVDRFQEGPEAPVFLISLKAGGEGLNLTAADHVIHYDLWWNPAVEEQAIDRAHRIGQTRDVQVYK 655
|
730 740
....*....|....*....|....*.
gi 6320541 1369 FVSEHTIESNILKKANQKRQL-DNVV 1393
Cdd:COG0553 656 LVAEGTIEEKILELLEEKRALaESVL 681
|
|
| SNF2-rel_dom |
pfam00176 |
SNF2-related domain; This domain is found in proteins involved in a variety of processes ... |
699-999 |
7.40e-94 |
|
SNF2-related domain; This domain is found in proteins involved in a variety of processes including transcription regulation (e.g., SNF2, STH1, brahma, MOT1), DNA repair (e.g., ERCC6, RAD16, RAD5), DNA recombination (e.g., RAD54), and chromatin unwinding (e.g., ISWI) as well as a variety of other proteins with little functional information (e.g., lodestar, ETL1). SNF2 functions as the ATPase component of the SNF2/SWI multisubunit complex, which utilizes energy derived from ATP hydrolysis to disrupt histone-DNA interactions, resulting in the increased accessibility of DNA to transcription factors.
Pssm-ID: 425504 [Multi-domain] Cd Length: 289 Bit Score: 304.99 E-value: 7.40e-94
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 699 YQKQGLNWLASLYNN-HTNGILADEMGLGKTIQTISLLAYLACEKENWG-PHLIVVPTSVLLNWEMEFKRFA--PGFKVL 774
Cdd:pfam00176 1 YQIEGVNWMLSLENNlGRGGILADEMGLGKTLQTISLLLYLKHVDKNWGgPTLIVVPLSLLHNWMNEFERWVspPALRVV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 775 TYYGSPQQRKEKRKGWNKPDAFHVCIVSYQLVVQDQHSFKRKRWQYMVLDEAHNIKNFRSTRWQALLNFNTQRRLLLTGT 854
Cdd:pfam00176 81 VLHGNKRPQERWKNDPNFLADFDVVITTYETLRKHKELLKKVHWHRIVLDEGHRLKNSKSKLSKALKSLKTRNRWILTGT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 855 PLQNNLAELWSLLYFLMPqtvidgkkvSGFADLDAFQQWFGRPVdkiietgqnfgQDKETKKTVAKLHQVLRPYLLRRLK 934
Cdd:pfam00176 161 PLQNNLEELWALLNFLRP---------GPFGSLSTFRNWFDRPI-----------ERGGGKKGVSRLHKLLKPFLLRRTK 220
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6320541 935 ADVEKQMPAKYEHIVYCKLSKRQRFLYDDFMSRAQTKATLAS----GNFMSIVNCLMQLRKVCNHPNLF 999
Cdd:pfam00176 221 KDVEKSLPPKVEYILFCRLSKLQRKLYQTFLLKKDLNAIKTGeggrEIKASLLNILMRLRKICNHPGLI 289
|
|
| PLN03142 |
PLN03142 |
Probable chromatin-remodeling complex ATPase chain; Provisional |
669-1035 |
3.97e-82 |
|
Probable chromatin-remodeling complex ATPase chain; Provisional
Pssm-ID: 215601 [Multi-domain] Cd Length: 1033 Bit Score: 293.25 E-value: 3.97e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 669 EEDAE-TKVQEEQLSVVD----VPVPSLLRGNLRTYQKQGLNWLASLYNNHTNGILADEMGLGKTIQTISLLAYLACEKE 743
Cdd:PLN03142 138 EEDEEyLKEEEDGLGGSGgtrlLVQPSCIKGKMRDYQLAGLNWLIRLYENGINGILADEMGLGKTLQTISLLGYLHEYRG 217
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 744 NWGPHLIVVPTSVLLNWEMEFKRFAPGFKVLTYYGSPQQRKEKRKGWNKPDAFHVCIVSYQLVVQDQHSFKRKRWQYMVL 823
Cdd:PLN03142 218 ITGPHMVVAPKSTLGNWMNEIRRFCPVLRAVKFHGNPEERAHQREELLVAGKFDVCVTSFEMAIKEKTALKRFSWRYIII 297
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 824 DEAHNIKNFRSTRWQALLNFNTQRRLLLTGTPLQNNLAELWSLLYFLMPQTvidgkkvsgFADLDAFQQWFgrpvdkiie 903
Cdd:PLN03142 298 DEAHRIKNENSLLSKTMRLFSTNYRLLITGTPLQNNLHELWALLNFLLPEI---------FSSAETFDEWF--------- 359
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 904 tgQNFGQDKETkKTVAKLHQVLRPYLLRRLKADVEKQMPAKYEHIVYCKLSKRQRFLYDDFMSRaQTKATLASGNFMSIV 983
Cdd:PLN03142 360 --QISGENDQQ-EVVQQLHKVLRPFLLRRLKSDVEKGLPPKKETILKVGMSQMQKQYYKALLQK-DLDVVNAGGERKRLL 435
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 6320541 984 NCLMQLRKVCNHPNLFE-VRPILTSFVLEHCVASDYKDV--ERTLLKLFKKNNQV 1035
Cdd:PLN03142 436 NIAMQLRKCCNHPYLFQgAEPGPPYTTGEHLVENSGKMVllDKLLPKLKERDSRV 490
|
|
| SF2_C_SNF |
cd18793 |
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) ... |
1235-1370 |
4.27e-59 |
|
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) family includes chromatin-remodeling factors, such as CHD proteins and SMARCA proteins, recombination proteins Rad54, and many others. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350180 [Multi-domain] Cd Length: 135 Bit Score: 199.24 E-value: 4.27e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 1235 FPDKSLLQYDcGKLQKLAILLQQLKDNGHRALIFTQMTKVLDVLEQFLNYHGYLYMRLDGATKIEDRQILTERFNTDSRI 1314
Cdd:cd18793 1 LPPKIEEVVS-GKLEALLELLEELREPGEKVLIFSQFTDTLDILEEALRERGIKYLRLDGSTSSKERQKLVDRFNEDPDI 79
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 6320541 1315 TVFILSSRSGGLGINLTGADTVIFYDSDWNPAMDKQCQDRCHRIGQTRDVHIYRFV 1370
Cdd:cd18793 80 RVFLLSTKAGGVGLNLTAANRVILYDPWWNPAVEEQAIDRAHRIGQKKPVVVYRLI 135
|
|
| PLN03142 |
PLN03142 |
Probable chromatin-remodeling complex ATPase chain; Provisional |
1246-1452 |
8.03e-47 |
|
Probable chromatin-remodeling complex ATPase chain; Provisional
Pssm-ID: 215601 [Multi-domain] Cd Length: 1033 Bit Score: 183.85 E-value: 8.03e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 1246 GKLQKLAILLQQLKDNGHRALIFTQMTKVLDVLEQFLNYHGYLYMRLDGATKIEDRQILTERFNTD-SRITVFILSSRSG 1324
Cdd:PLN03142 471 GKMVLLDKLLPKLKERDSRVLIFSQMTRLLDILEDYLMYRGYQYCRIDGNTGGEDRDASIDAFNKPgSEKFVFLLSTRAG 550
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 1325 GLGINLTGADTVIFYDSDWNPAMDKQCQDRCHRIGQTRDVHIYRFVSEHTIESNILKKANQKRQLDNVVIQEGDFTTDyf 1404
Cdd:PLN03142 551 GLGINLATADIVILYDSDWNPQVDLQAQDRAHRIGQKKEVQVFRFCTEYTIEEKVIERAYKKLALDALVIQQGRLAEQ-- 628
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 6320541 1405 SKLSVRDLL-----GSELpenASGGDKPLIADADVaakdprqlERLLAQAEDE 1452
Cdd:PLN03142 629 KTVNKDELLqmvryGAEM---VFSSKDSTITDEDI--------DRIIAKGEEA 670
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
688-872 |
2.35e-30 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 119.52 E-value: 2.35e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 688 VPSLLRGNLRTYQKQGLNWLaslYNNHTNGILADEMGLGKTIQ-TISLLAYLAceKENWGPHLIVVPTSVLL-NWEMEFK 765
Cdd:smart00487 1 IEKFGFEPLRPYQKEAIEAL---LSGLRDVILAAPTGSGKTLAaLLPALEALK--RGKGGRVLVLVPTRELAeQWAEELK 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 766 RFAP--GFKVLTYYGSPQQRKEKRKgWNKPDaFHVCIVSYQLVVQD--QHSFKRKRWQYMVLDEAHNIKNF-RSTRWQAL 840
Cdd:smart00487 76 KLGPslGLKVVGLYGGDSKREQLRK-LESGK-TDILVTTPGRLLDLleNDKLSLSNVDLVILDEAHRLLDGgFGDQLEKL 153
|
170 180 190
....*....|....*....|....*....|....*..
gi 6320541 841 LNF--NTQRRLLLTGTP---LQNNLAELWSLLYFLMP 872
Cdd:smart00487 154 LKLlpKNVQLLLLSATPpeeIENLLELFLNDPVFIDV 190
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
1249-1359 |
4.04e-26 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 104.21 E-value: 4.04e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 1249 QKLAILLQQLKDN-GHRALIFTQMTKVLDvLEQFLNYHGYLYMRLDGATKIEDRQILTERFNTDSRItvFILSSRSGGLG 1327
Cdd:pfam00271 1 EKLEALLELLKKErGGKVLIFSQTKKTLE-AELLLEKEGIKVARLHGDLSQEEREEILEDFRKGKID--VLVATDVAERG 77
|
90 100 110
....*....|....*....|....*....|..
gi 6320541 1328 INLTGADTVIFYDSDWNPAMDKQCQDRCHRIG 1359
Cdd:pfam00271 78 LDLPDVDLVINYDLPWNPASYIQRIGRAGRAG 109
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
1276-1359 |
4.97e-21 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 88.42 E-value: 4.97e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 1276 DVLEQFLNYHGYLYMRLDGATKIEDRQILTERFNTDSRitVFILSSRSGGLGINLTGADTVIFYDSDWNPAMDKQCQDRC 1355
Cdd:smart00490 1 EELAELLKELGIKVARLHGGLSQEEREEILDKFNNGKI--KVLVATDVAERGLDLPGVDLVIIYDLPWSPASYIQRIGRA 78
|
....
gi 6320541 1356 HRIG 1359
Cdd:smart00490 79 GRAG 82
|
|
| SSL2 |
COG1061 |
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair]; |
627-855 |
3.65e-17 |
|
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
Pssm-ID: 440681 [Multi-domain] Cd Length: 566 Bit Score: 87.00 E-value: 3.65e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 627 NSSSVEGEELEKDQVDNSAATFERAGDFVHTQNENRDDIKDVEEDAETKVQEEQLSVVDVPVPSllRGNLRTYQKQGLN- 705
Cdd:COG1061 14 LRSSLLLLDLERLELSLLRNLVEARRLAIKEGTREDGRRLPEEDTERELAEAEALEAGDEASGT--SFELRPYQQEALEa 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 706 WLASLYNNHTNGILADEMGLGKTIqtisLLAYLACEKENWGPHLIVVPTSVLLN-WEMEFKRFAPGFKVltyygspqqrk 784
Cdd:COG1061 92 LLAALERGGGRGLVVAPTGTGKTV----LALALAAELLRGKRVLVLVPRRELLEqWAEELRRFLGDPLA----------- 156
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 6320541 785 ekrKGWNKPDAFHVCIVSYQLVVQDQHSFK-RKRWQYMVLDEAHNIknfRSTRWQALLN-FNTQRRLLLTGTP 855
Cdd:COG1061 157 ---GGGKKDSDAPITVATYQSLARRAHLDElGDRFGLVIIDEAHHA---GAPSYRRILEaFPAAYRLGLTATP 223
|
|
| HSA |
smart00573 |
domain in helicases and associated with SANT domains; |
340-393 |
5.99e-13 |
|
domain in helicases and associated with SANT domains;
Pssm-ID: 214727 [Multi-domain] Cd Length: 73 Bit Score: 65.50 E-value: 5.99e-13
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 6320541 340 SYFYKQQDLQIHTDHLINQGIHMSKLFRSSTKARIARAKKVSQMIEQHFKHVAG 393
Cdd:smart00573 1 QKLEEERRRKQHWDHLLEEMIWHAKDFKEEHKWKIAAAKKMAKAVMDYHQNKEK 54
|
|
| DISARM_DrmD_b |
NF038318 |
DISARM system SNF2-like helicase DrmD, short form; DrmD, a SNF2-like helicase, is a component ... |
718-1364 |
1.00e-11 |
|
DISARM system SNF2-like helicase DrmD, short form; DrmD, a SNF2-like helicase, is a component of class 1 DISARM (Defence Island System Associated with Restriction Modification), which contains a DNA adenine N6 methyltransferase. This HMM describes a distinct form that is somewhat shorter than the majority of DrmD proteins.
Pssm-ID: 468472 [Multi-domain] Cd Length: 868 Bit Score: 70.10 E-value: 1.00e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 718 ILADEMGLGKTIQTISLLAYLACEKENwgPHLIVVPTSVLLNWEMEF-KRFAPGFKVLTYYGSPQQRKEKRKGWNKPDAF 796
Cdd:NF038318 51 ILADEVGLGKTIEAGLVLKYVLESGAK--KILIILPANLRKQWEIELeEKFDLESLILDSLTVEKDAKKWNKRLTDNKKV 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 797 HVCIVSYQLVVQDQHSFKRKRWQYMVLDEAHNIKN-FRSTRWQALLNFNTQR--RLLLTGTPLQNNLAELWSLLYFLMPQ 873
Cdd:NF038318 129 RIVITSYDYASKLMKRFPKVKWDFIIIDEAHNLRNvHKGGKRAKNLYELTKGipKILLTATPLQNSLLDLYGLVSFIDPR 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 874 tVIDGKKVsgfadldaFQQWFGRpvdkiietGQNFgqdketkktvAKLHQVLRPYLLRRLKADVEKQM--PAKYEHIVYC 951
Cdd:NF038318 209 -IFGSEKV--------FSKRYIK--------DEDY----------SDLKRELSPVLYRTLRKDVADYMqfKKRKCITVDF 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 952 KLSKRQRFLYDdfmsraqtkatlasgnfmsivnclmqlrKVcnhpNLFEVRPILTSFVLEHcvasdykdveRTLLKLfkk 1031
Cdd:NF038318 262 ELSPDEIELYV----------------------------RV----NNFLKRDILYSIPTSN----------RTLIIL--- 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 1032 nnqVNRvdldflnlvftlndKDLTSyhaeeiSKLTCVKNFV---EEVNKLRETNKQLQEEFGEASFLNFqdanqyfkysn 1108
Cdd:NF038318 297 ---VIR--------------KLLAS------SSFALAETFEvlkKRLEKLKEGTRSANAQEGFDLFWSF----------- 342
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 1109 kqkLEGTVDmlnflkmvnklrcdrrpifgknlidllTKDRRVKYDKSSIIDNELIkplQTRVLDNRKIIDTfavltpsAV 1188
Cdd:NF038318 343 ---VEDEID---------------------------ESGFEEKQDELYTRQKEFI---QHEIDEVDAIIDV-------AK 382
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 1189 SLdmrklalglnddssvgeNTRLKVmqncfevsnplHQLQTKLTIAFPdkslLQYDCGKLQKLAI----------LLQQL 1258
Cdd:NF038318 383 RI-----------------KTNAKV-----------TALKTALEIAFE----YQREEGIAQKVVVfteskrtqkyIAEEL 430
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 1259 KDNGHRA---LIFT-----QMTKVLDVLEQFLNYHGYLYMRldgatKIEDRQILTERFNTDSRItvfILSSRSGGLGINL 1330
Cdd:NF038318 431 RKSGYEGediLLFNgdfddAMTKEIYRAWQVKNYGKANYGR-----SVEYKHAIVDYFKNNAKI---LIVTDAGSEGLNL 502
|
650 660 670
....*....|....*....|....*....|....
gi 6320541 1331 TGADTVIFYDSDWNPAMDKQCQDRCHRIGQTRDV 1364
Cdd:NF038318 503 QFCNTVINYDLPWNPQKIEQRIGRCHRYGQKNDV 536
|
|
| HSA |
pfam07529 |
HSA domain; This domain is predicted to bind DNA and is often found associated with helicases. ... |
351-393 |
1.75e-09 |
|
HSA domain; This domain is predicted to bind DNA and is often found associated with helicases. This region does not form a compact domain in the known structures.
Pssm-ID: 462194 [Multi-domain] Cd Length: 67 Bit Score: 55.27 E-value: 1.75e-09
10 20 30 40
....*....|....*....|....*....|....*....|...
gi 6320541 351 HTDHLINQGIHMSKLFRSSTKARIARAKKVSQMIEQHFKHVAG 393
Cdd:pfam07529 11 HHDYLLEEILWHSKDFKQERRWKRARAKKLARAVAQYHKNIEK 53
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| DEXQc_SRCAP |
cd18003 |
DEXH/Q-box helicase domain of SRCAP; Snf2-related CBP activator (SRCAP, also known as SWR1 or ... |
696-932 |
4.42e-152 |
|
DEXH/Q-box helicase domain of SRCAP; Snf2-related CBP activator (SRCAP, also known as SWR1 or DOMO1) is the core catalytic component of the multiprotein chromatin-remodeling SRCAP complex, that is necessary for the incorporation of the histone variant H2A.Z into nucleosomes. SRCAP is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350761 [Multi-domain] Cd Length: 223 Bit Score: 461.05 E-value: 4.42e-152
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 696 LRTYQKQGLNWLASLYNNHTNGILADEMGLGKTIQTISLLAYLACEKENWGPHLIVVPTSVLLNWEMEFKRFAPGFKVLT 775
Cdd:cd18003 1 LREYQHIGLDWLATLYEKNLNGILADEMGLGKTIQTIALLAHLACEKGNWGPHLIVVPTSVMLNWEMEFKRWCPGFKILT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 776 YYGSPQQRKEKRKGWNKPDAFHVCIVSYQLVVQDQHSFKRKRWQYMVLDEAHNIKNFRSTRWQALLNFNTQRRLLLTGTP 855
Cdd:cd18003 81 YYGSAKERKLKRQGWMKPNSFHVCITSYQLVVQDHQVFKRKKWKYLILDEAHNIKNFKSQRWQTLLNFNTQRRLLLTGTP 160
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 6320541 856 LQNNLAELWSLLYFLMPqtvidgkkvSGFADLDAFQQWFGRPVDKIIETGQNfgqdkETKKTVAKLHQVLRPYLLRR 932
Cdd:cd18003 161 LQNSLMELWSLMHFLMP---------HIFQSHQEFKEWFSNPLTAMSEGSQE-----ENEELVRRLHKVLRPFLLRR 223
|
|
| HepA |
COG0553 |
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ... |
649-1393 |
1.49e-107 |
|
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];
Pssm-ID: 440319 [Multi-domain] Cd Length: 682 Bit Score: 357.61 E-value: 1.49e-107
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 649 ERAGDFVHTQNENRDDIKDVEEDAETKVQEEQLSVVDVPVPSLLRGNLRTYQKQGLNWLASLYNNHTNGILADEMGLGKT 728
Cdd:COG0553 195 LAAEAELLLLLELLLELELLAEAAVDAFRLRRLREALESLPAGLKATLRPYQLEGAAWLLFLRRLGLGGLLADDMGLGKT 274
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 729 IQTISLLAYLAcEKENWGPHLIVVPTSVLLNWEMEFKRFAPGFKVLTYYGsPQQRKEKRKGWNKPDafhVCIVSYQLVVQ 808
Cdd:COG0553 275 IQALALLLELK-ERGLARPVLIVAPTSLVGNWQRELAKFAPGLRVLVLDG-TRERAKGANPFEDAD---LVITSYGLLRR 349
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 809 DQHSFKRKRWQYMVLDEAHNIKNFRSTRWQALLNFNTQRRLLLTGTPLQNNLAELWSLLYFLMPQTvidgkkvsgFADLD 888
Cdd:COG0553 350 DIELLAAVDWDLVILDEAQHIKNPATKRAKAVRALKARHRLALTGTPVENRLEELWSLLDFLNPGL---------LGSLK 420
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 889 AFQQWFGRPVDKiietgqnfgqdkETKKTVAKLHQVLRPyllrrlkadvekqmpakyehivycklskrqrflyddfmsra 968
Cdd:COG0553 421 AFRERFARPIEK------------GDEEALERLRRLLRP----------------------------------------- 447
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 969 qtkatlasgnFMsivnclmqlrkvcnhpnlfevrpiltsfvlehcvasdykdvertllklfkknnqvnrvdldflnlvft 1048
Cdd:COG0553 448 ----------FL-------------------------------------------------------------------- 449
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 1049 lndkdltsyhaeeiskltcvknfveevnkLRETNKQLQEEFGEasflnfqdanqyfkysnkqklegtvdmlnflKMVNKL 1128
Cdd:COG0553 450 -----------------------------LRRTKEDVLKDLPE-------------------------------KTEETL 469
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 1129 RCDrrpifgknlidlLTKDRRVKYDKssiIDNELIKPLQTRVLDNRKIidtfavltpsaVSLDMRklalglnddssvgen 1208
Cdd:COG0553 470 YVE------------LTPEQRALYEA---VLEYLRRELEGAEGIRRRG-----------LILAAL--------------- 508
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 1209 TRLKvmQNCfevSNPLHQLQtkltiafpDKSLLQYDCGKLQKLAILLQQLKDNGHRALIFTQMTKVLDVLEQFLNYHGYL 1288
Cdd:COG0553 509 TRLR--QIC---SHPALLLE--------EGAELSGRSAKLEALLELLEELLAEGEKVLVFSQFTDTLDLLEERLEERGIE 575
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 1289 YMRLDGATKIEDRQILTERFNTDSRITVFILSSRSGGLGINLTGADTVIFYDSDWNPAMDKQCQDRCHRIGQTRDVHIYR 1368
Cdd:COG0553 576 YAYLHGGTSAEERDELVDRFQEGPEAPVFLISLKAGGEGLNLTAADHVIHYDLWWNPAVEEQAIDRAHRIGQTRDVQVYK 655
|
730 740
....*....|....*....|....*.
gi 6320541 1369 FVSEHTIESNILKKANQKRQL-DNVV 1393
Cdd:COG0553 656 LVAEGTIEEKILELLEEKRALaESVL 681
|
|
| SNF2-rel_dom |
pfam00176 |
SNF2-related domain; This domain is found in proteins involved in a variety of processes ... |
699-999 |
7.40e-94 |
|
SNF2-related domain; This domain is found in proteins involved in a variety of processes including transcription regulation (e.g., SNF2, STH1, brahma, MOT1), DNA repair (e.g., ERCC6, RAD16, RAD5), DNA recombination (e.g., RAD54), and chromatin unwinding (e.g., ISWI) as well as a variety of other proteins with little functional information (e.g., lodestar, ETL1). SNF2 functions as the ATPase component of the SNF2/SWI multisubunit complex, which utilizes energy derived from ATP hydrolysis to disrupt histone-DNA interactions, resulting in the increased accessibility of DNA to transcription factors.
Pssm-ID: 425504 [Multi-domain] Cd Length: 289 Bit Score: 304.99 E-value: 7.40e-94
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 699 YQKQGLNWLASLYNN-HTNGILADEMGLGKTIQTISLLAYLACEKENWG-PHLIVVPTSVLLNWEMEFKRFA--PGFKVL 774
Cdd:pfam00176 1 YQIEGVNWMLSLENNlGRGGILADEMGLGKTLQTISLLLYLKHVDKNWGgPTLIVVPLSLLHNWMNEFERWVspPALRVV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 775 TYYGSPQQRKEKRKGWNKPDAFHVCIVSYQLVVQDQHSFKRKRWQYMVLDEAHNIKNFRSTRWQALLNFNTQRRLLLTGT 854
Cdd:pfam00176 81 VLHGNKRPQERWKNDPNFLADFDVVITTYETLRKHKELLKKVHWHRIVLDEGHRLKNSKSKLSKALKSLKTRNRWILTGT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 855 PLQNNLAELWSLLYFLMPqtvidgkkvSGFADLDAFQQWFGRPVdkiietgqnfgQDKETKKTVAKLHQVLRPYLLRRLK 934
Cdd:pfam00176 161 PLQNNLEELWALLNFLRP---------GPFGSLSTFRNWFDRPI-----------ERGGGKKGVSRLHKLLKPFLLRRTK 220
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6320541 935 ADVEKQMPAKYEHIVYCKLSKRQRFLYDDFMSRAQTKATLAS----GNFMSIVNCLMQLRKVCNHPNLF 999
Cdd:pfam00176 221 KDVEKSLPPKVEYILFCRLSKLQRKLYQTFLLKKDLNAIKTGeggrEIKASLLNILMRLRKICNHPGLI 289
|
|
| DEXQc_INO80 |
cd18002 |
DEAQ-box helicase domain of INO80; INO80 is the catalytic ATPase subunit of the INO80 ... |
696-932 |
1.48e-85 |
|
DEAQ-box helicase domain of INO80; INO80 is the catalytic ATPase subunit of the INO80 chromatin remodeling complex. INO80 removes histone H3-containing nucleosomes from associated chromatin, promotes CENP-ACnp1 chromatin assembly at the centromere in a redundant manner with another chromatin-remodeling factor Chd1Hrp1. INO80 mutants have severe defects in oxygen consumption and promiscuous cell division that is no longer coupled with metabolic status. INO80 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350760 [Multi-domain] Cd Length: 229 Bit Score: 279.00 E-value: 1.48e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 696 LRTYQKQGLNWLASLYNNHTNGILADEMGLGKTIQTISLLAYLACEKENWGPHLIVVPTSVLLNWEMEFKRFAPGFKVLT 775
Cdd:cd18002 1 LKEYQLKGLNWLANLYEQGINGILADEMGLGKTVQSIAVLAHLAEEHNIWGPFLVIAPASTLHNWQQEISRFVPQFKVLP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 776 YYGSPQQRKEKRKGWNKP-----DA-FHVCIVSYQLVVQDQHSFKRKRWQYMVLDEAHNIKNFRSTRWQALLNFNTQRRL 849
Cdd:cd18002 81 YWGNPKDRKVLRKFWDRKnlytrDApFHVVITSYQLVVQDEKYFQRVKWQYMVLDEAQAIKSSSSSRWKTLLSFHCRNRL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 850 LLTGTPLQNNLAELWSLLYFLMPQTvidgkkvsgFADLDAFQQWFGRPVDKIIETGQNFGQDKetkktVAKLHQVLRPYL 929
Cdd:cd18002 161 LLTGTPIQNSMAELWALLHFIMPTL---------FDSHDEFNEWFSKDIESHAENKTGLNEHQ-----LKRLHMILKPFM 226
|
...
gi 6320541 930 LRR 932
Cdd:cd18002 227 LRR 229
|
|
| DEXHc_SMARCA2_SMARCA4 |
cd17996 |
DEXH-box helicase domain of SMARCA2 and SMARCA4; SWI/SNF related, matrix associated, actin ... |
694-934 |
1.58e-85 |
|
DEXH-box helicase domain of SMARCA2 and SMARCA4; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, members 2 and 4 (SMARCA2 and SMARCA4) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350754 [Multi-domain] Cd Length: 233 Bit Score: 278.87 E-value: 1.58e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 694 GNLRTYQKQGLNWLASLYNNHTNGILADEMGLGKTIQTISLLAYLACEKENWGPHLIVVPTSVLLNWEMEFKRFAPGFKV 773
Cdd:cd17996 2 GTLKEYQLKGLQWMVSLYNNNLNGILADEMGLGKTIQTISLITYLMEKKKNNGPYLVIVPLSTLSNWVSEFEKWAPSVSK 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 774 LTYYGSPQQRKEKRKGwNKPDAFHVCIVSYQLVVQDQHSFKRKRWQYMVLDEAHNIKNFRSTRWQALLN-FNTQRRLLLT 852
Cdd:cd17996 82 IVYKGTPDVRKKLQSQ-IRAGKFNVLLTTYEYIIKDKPLLSKIKWKYMIIDEGHRMKNAQSKLTQTLNTyYHARYRLLLT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 853 GTPLQNNLAELWSLLYFLMPQTvidgkkvsgFADLDAFQQWFGRPVDKIIETGQNFGQDKETKKTVAKLHQVLRPYLLRR 932
Cdd:cd17996 161 GTPLQNNLPELWALLNFLLPKI---------FKSCKTFEQWFNTPFANTGEQVKIELNEEETLLIIRRLHKVLRPFLLRR 231
|
..
gi 6320541 933 LK 934
Cdd:cd17996 232 LK 233
|
|
| DEXHc_Snf |
cd17919 |
DEXH/Q-box helicase domain of DEAD-like helicase Snf family proteins; Sucrose Non-Fermenting ... |
696-873 |
6.04e-85 |
|
DEXH/Q-box helicase domain of DEAD-like helicase Snf family proteins; Sucrose Non-Fermenting (SNF) proteins DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350677 [Multi-domain] Cd Length: 182 Bit Score: 275.21 E-value: 6.04e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 696 LRTYQKQGLNWLASLYNNHTNGILADEMGLGKTIQTISLLAYLACEKENWGPHLIVVPTSVLLNWEMEFKRFAPGFKVLT 775
Cdd:cd17919 1 LRPYQLEGLNFLLELYENGPGGILADEMGLGKTLQAIAFLAYLLKEGKERGPVLVVCPLSVLENWEREFEKWTPDLRVVV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 776 YYGSPQQRKEKRKGWnKPDAFHVCIVSYQLVVQDQHSFKRKRWQYMVLDEAHNIKNFRSTRWQALLNFNTQRRLLLTGTP 855
Cdd:cd17919 81 YHGSQRERAQIRAKE-KLDKFDVVLTTYETLRRDKASLRKFRWDLVVVDEAHRLKNPKSQLSKALKALRAKRRLLLTGTP 159
|
170
....*....|....*...
gi 6320541 856 LQNNLAELWSLLYFLMPQ 873
Cdd:cd17919 160 LQNNLEELWALLDFLDPP 177
|
|
| DEXHc_SMARCA1_SMARCA5 |
cd17997 |
DEAH-box helicase domain of SMARCA1 and SMARCA5; SWI/SNF related, matrix associated, actin ... |
694-934 |
2.75e-83 |
|
DEAH-box helicase domain of SMARCA1 and SMARCA5; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 and 5 (SMARCA1 and SMARCA5) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350755 [Multi-domain] Cd Length: 222 Bit Score: 272.27 E-value: 2.75e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 694 GNLRTYQKQGLNWLASLYNNHTNGILADEMGLGKTIQTISLLAYLACEKENWGPHLIVVPTSVLLNWEMEFKRFAPGFKV 773
Cdd:cd17997 2 GTMRDYQIRGLNWLISLFENGINGILADEMGLGKTLQTISLLGYLKHYKNINGPHLIIVPKSTLDNWMREFKRWCPSLRV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 774 LTYYGSPQQRKEKRKGWNKPDAFHVCIVSYQLVVQDQHSFKRKRWQYMVLDEAHNIKNFRSTRWQALLNFNTQRRLLLTG 853
Cdd:cd17997 82 VVLIGDKEERADIIRDVLLPGKFDVCITSYEMVIKEKTVLKKFNWRYIIIDEAHRIKNEKSKLSQIVRLFNSRNRLLLTG 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 854 TPLQNNLAELWSLLYFLMPQTvidgkkvsgFADLDAFQQWFGRPVDkiietgqnfgqDKETKKTVAKLHQVLRPYLLRRL 933
Cdd:cd17997 162 TPLQNNLHELWALLNFLLPDV---------FTSSEDFDEWFNVNNC-----------DDDNQEVVQRLHKVLRPFLLRRI 221
|
.
gi 6320541 934 K 934
Cdd:cd17997 222 K 222
|
|
| PLN03142 |
PLN03142 |
Probable chromatin-remodeling complex ATPase chain; Provisional |
669-1035 |
3.97e-82 |
|
Probable chromatin-remodeling complex ATPase chain; Provisional
Pssm-ID: 215601 [Multi-domain] Cd Length: 1033 Bit Score: 293.25 E-value: 3.97e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 669 EEDAE-TKVQEEQLSVVD----VPVPSLLRGNLRTYQKQGLNWLASLYNNHTNGILADEMGLGKTIQTISLLAYLACEKE 743
Cdd:PLN03142 138 EEDEEyLKEEEDGLGGSGgtrlLVQPSCIKGKMRDYQLAGLNWLIRLYENGINGILADEMGLGKTLQTISLLGYLHEYRG 217
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 744 NWGPHLIVVPTSVLLNWEMEFKRFAPGFKVLTYYGSPQQRKEKRKGWNKPDAFHVCIVSYQLVVQDQHSFKRKRWQYMVL 823
Cdd:PLN03142 218 ITGPHMVVAPKSTLGNWMNEIRRFCPVLRAVKFHGNPEERAHQREELLVAGKFDVCVTSFEMAIKEKTALKRFSWRYIII 297
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 824 DEAHNIKNFRSTRWQALLNFNTQRRLLLTGTPLQNNLAELWSLLYFLMPQTvidgkkvsgFADLDAFQQWFgrpvdkiie 903
Cdd:PLN03142 298 DEAHRIKNENSLLSKTMRLFSTNYRLLITGTPLQNNLHELWALLNFLLPEI---------FSSAETFDEWF--------- 359
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 904 tgQNFGQDKETkKTVAKLHQVLRPYLLRRLKADVEKQMPAKYEHIVYCKLSKRQRFLYDDFMSRaQTKATLASGNFMSIV 983
Cdd:PLN03142 360 --QISGENDQQ-EVVQQLHKVLRPFLLRRLKSDVEKGLPPKKETILKVGMSQMQKQYYKALLQK-DLDVVNAGGERKRLL 435
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 6320541 984 NCLMQLRKVCNHPNLFE-VRPILTSFVLEHCVASDYKDV--ERTLLKLFKKNNQV 1035
Cdd:PLN03142 436 NIAMQLRKCCNHPYLFQgAEPGPPYTTGEHLVENSGKMVllDKLLPKLKERDSRV 490
|
|
| DEXHc_HELLS_SMARCA6 |
cd18009 |
DEXH-box helicase domain of HELLS; HELLS (helicase, lymphoid specific, also known as Lsh or ... |
694-934 |
4.56e-80 |
|
DEXH-box helicase domain of HELLS; HELLS (helicase, lymphoid specific, also known as Lsh or SMARCA6) is a major epigenetic regulator crucial for normal heterochromatin structure and function. HELLS is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350767 [Multi-domain] Cd Length: 236 Bit Score: 263.48 E-value: 4.56e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 694 GNLRTYQKQGLNWLASLYNNHTNGILADEMGLGKTIQTISLLAYLAcEKENWGPHLIVVPTSVLLNWEMEFKRFAPGFKV 773
Cdd:cd18009 2 GVMRPYQLEGMEWLRMLWENGINGILADEMGLGKTIQTIALLAHLR-ERGVWGPFLVIAPLSTLPNWVNEFARFTPSVPV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 774 LTYYGSPQQRKEKRKGWNKP----DAFHVCIVSYQLVVQDQHSFKRKRWQYMVLDEAHNIKNFRSTRWQALLNFNTQRRL 849
Cdd:cd18009 81 LLYHGTKEERERLRKKIMKRegtlQDFPVVVTSYEIAMRDRKALQHYAWKYLIVDEGHRLKNLNCRLIQELKTFNSDNRL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 850 LLTGTPLQNNLAELWSLLYFLMPQTvidgkkvsgFADLDAFQQWFGrpVDKIIETGQNFGQDKETKKT--VAKLHQVLRP 927
Cdd:cd18009 161 LLTGTPLQNNLSELWSLLNFLLPDV---------FDDLSSFESWFD--FSSLSDNAADISNLSEEREQniVHMLHAILKP 229
|
....*..
gi 6320541 928 YLLRRLK 934
Cdd:cd18009 230 FLLRRLK 236
|
|
| DEXQc_arch_SWI2_SNF2 |
cd18012 |
DEAQ-box helicase domain of archaeal and bacterial SNF2-related proteins; Proteins belonging ... |
692-934 |
1.77e-74 |
|
DEAQ-box helicase domain of archaeal and bacterial SNF2-related proteins; Proteins belonging to SNF2 family of DNA dependent ATPases are important members of the chromatin remodeling complexes that are implicated in epigenetic control of gene expression. The Snf2 family comprises a large group of ATP-hydrolyzing proteins that are ubiquitous in eukaryotes, but also present in eubacteria and archaea. Archaeal SWI2 and SNF2 are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350770 [Multi-domain] Cd Length: 218 Bit Score: 246.71 E-value: 1.77e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 692 LRGNLRTYQKQGLNWLASLYNNHTNGILADEMGLGKTIQTISLLAYLAcEKENWGPHLIVVPTSVLLNWEMEFKRFAPGF 771
Cdd:cd18012 1 LKATLRPYQKEGFNWLSFLRHYGLGGILADDMGLGKTLQTLALLLSRK-EEGRKGPSLVVAPTSLIYNWEEEAAKFAPEL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 772 KVLTYYGSPQQRKEKRKgWNKPDafhVCIVSYQLVVQDQHSFKRKRWQYMVLDEAHNIKNFRSTRWQALLNFNTQRRLLL 851
Cdd:cd18012 80 KVLVIHGTKRKREKLRA-LEDYD---LVITSYGLLRRDIELLKEVKFHYLVLDEAQNIKNPQTKTAKAVKALKADHRLAL 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 852 TGTPLQNNLAELWSLLYFLMPqtvidgkkvsGF-ADLDAFQQWFGRPVDKiietgqnfGQDKETKktvAKLHQVLRPYLL 930
Cdd:cd18012 156 TGTPIENHLGELWSIFDFLNP----------GLlGSYKRFKKRFAKPIEK--------DGDEEAL---EELKKLISPFIL 214
|
....
gi 6320541 931 RRLK 934
Cdd:cd18012 215 RRLK 218
|
|
| DEXHc_SMARCA5 |
cd18064 |
DEAH-box helicase domain of SMARCA5; SWI/SNF related, matrix associated, actin dependent ... |
689-944 |
1.59e-67 |
|
DEAH-box helicase domain of SMARCA5; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 (SMARCA5, also called SNF2H) is the catalytic subunit of the four known chromatin-remodeling complexes: CHRAC, RSF, ACF/WCRF, and WICH. SMARCA5 plays a major role organising arrays of nucleosomes adjacent to the binding sites for the architectural transcription factor CTCF sites and acts to promote CTCF binding SMARCA5 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350822 [Multi-domain] Cd Length: 244 Bit Score: 228.01 E-value: 1.59e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 689 PSLLR-GNLRTYQKQGLNWLASLYNNHTNGILADEMGLGKTIQTISLLAYLACEKENWGPHLIVVPTSVLLNWEMEFKRF 767
Cdd:cd18064 8 PSYVKwGKLRDYQVRGLNWLISLYENGINGILADEMGLGKTLQTISLLGYMKHYRNIPGPHMVLVPKSTLHNWMAEFKRW 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 768 APGFKVLTYYGSPQQRKEKRKGWNKPDAFHVCIVSYQLVVQDQHSFKRKRWQYMVLDEAHNIKNFRSTRWQALLNFNTQR 847
Cdd:cd18064 88 VPTLRAVCLIGDKDQRAAFVRDVLLPGEWDVCVTSYEMLIKEKSVFKKFNWRYLVIDEAHRIKNEKSKLSEIVREFKTTN 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 848 RLLLTGTPLQNNLAELWSLLYFLMPQTvidgkkvsgFADLDAFQQWFgrpvdkiiETGQNFGQdketKKTVAKLHQVLRP 927
Cdd:cd18064 168 RLLLTGTPLQNNLHELWALLNFLLPDV---------FNSAEDFDSWF--------DTNNCLGD----QKLVERLHMVLRP 226
|
250
....*....|....*..
gi 6320541 928 YLLRRLKADVEKQMPAK 944
Cdd:cd18064 227 FLLRRIKADVEKSLPPK 243
|
|
| DEXHc_CHD1_2 |
cd17993 |
DEXH-box helicase domain of the chromodomain helicase DNA binding proteins 1 and 2, and ... |
696-932 |
2.07e-67 |
|
DEXH-box helicase domain of the chromodomain helicase DNA binding proteins 1 and 2, and similar proteins; Chromodomain-helicase-DNA-binding protein 1 (CHD1) is an ATP-dependent chromatin-remodeling factor which functions as the substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. It regulates polymerase II transcription and is also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. It is not only involved in transcription-related chromatin-remodeling, but is also required to maintain a specific chromatin configuration across the genome. CHD1 is also associated with histone deacetylase (HDAC) activity. Chromodomain-helicase-DNA-binding protein 2 (CHD2) is a DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. It is involved in myogenesis via interaction with MYOD1; it binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression. Both are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350751 [Multi-domain] Cd Length: 218 Bit Score: 226.47 E-value: 2.07e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 696 LRTYQKQGLNWLASLYNNHTNGILADEMGLGKTIQTISLLAYLACEKENWGPHLIVVPTSVLLNWEMEFKRFAPGFKVLT 775
Cdd:cd17993 2 LRDYQLTGLNWLAHSWCKGNNGILADEMGLGKTVQTISFLSYLFHSQQQYGPFLVVVPLSTMPAWQREFAKWAPDMNVIV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 776 YYGSPQQRKEKRK-----GWNKPDAFHVCIVSYQLVVQDQHSFKRKRWQYMVLDEAHNIKNFRSTRWQALLNFNTQRRLL 850
Cdd:cd17993 82 YLGDIKSRDTIREyefyfSQTKKLKFNVLLTTYEIILKDKAFLGSIKWQYLAVDEAHRLKNDESLLYEALKEFKTNNRLL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 851 LTGTPLQNNLAELWSLLYFLMPqtvidGKkvsgFADLDAFqqwfgrpvdkiietgqNFGQDKETKKTVAKLHQVLRPYLL 930
Cdd:cd17993 162 ITGTPLQNSLKELWALLHFLMP-----GK----FDIWEEF----------------EEEHDEEQEKGIADLHKELEPFIL 216
|
..
gi 6320541 931 RR 932
Cdd:cd17993 217 RR 218
|
|
| DEXHc_SMARCAD1 |
cd17998 |
DEXH-box helicase domain of SMARCAD1; SWI/SNF-related matrix-associated actin-dependent ... |
696-876 |
4.18e-65 |
|
DEXH-box helicase domain of SMARCAD1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 (SMARCAD1, also known as ATP-dependent helicase 1 or Hel1) possesses intrinsic ATP-dependent nucleosome-remodeling activity and is required for both DNA repair and heterochromatin organization. SMARCAD1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350756 [Multi-domain] Cd Length: 187 Bit Score: 218.79 E-value: 4.18e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 696 LRTYQKQGLNWLASLYNNHTNGILADEMGLGKTIQTISLLAYLAcEKENWGPHLIVVPTSVLLNWEMEFKRFAPGFKVLT 775
Cdd:cd17998 1 LKDYQLIGLNWLNLLYQKKLSGILADEMGLGKTIQVIAFLAYLK-EIGIPGPHLVVVPSSTLDNWLREFKRWCPSLKVEP 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 776 YYGSPQQRKEKRKG-WNKPDAFHVCIVSYQLVVQDQHS---FKRKRWQYMVLDEAHNIKNFRSTRWQALLNFNTQRRLLL 851
Cdd:cd17998 80 YYGSQEERKHLRYDiLKGLEDFDVIVTTYNLATSNPDDrsfFKRLKLNYVVYDEGHMLKNMTSERYRHLMTINANFRLLL 159
|
170 180
....*....|....*....|....*
gi 6320541 852 TGTPLQNNLAELWSLLYFLMPQTVI 876
Cdd:cd17998 160 TGTPLQNNLLELMSLLNFIMPKPFI 184
|
|
| DEXHc_CHD6_7_8_9 |
cd17995 |
DEXH-box helicase domain of the chromodomain helicase DNA binding protein 6, 7, 8 and 9; ... |
696-932 |
2.13e-64 |
|
DEXH-box helicase domain of the chromodomain helicase DNA binding protein 6, 7, 8 and 9; Chromodomain-helicase-DNA-binding protein 6-9 (CHD6, CHD7, CHD8, and CHD9) are members of the DEAD-like helicases superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350753 [Multi-domain] Cd Length: 223 Bit Score: 218.27 E-value: 2.13e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 696 LRTYQKQGLNWLASLYNNHTNGILADEMGLGKTIQTISLLAYLACEKENWGPHLIVVPTSVLLNWEMEFKRFAPgFKVLT 775
Cdd:cd17995 1 LRDYQLEGVNWLLFNWYNRRNCILADEMGLGKTIQSIAFLEHLYQVEGIRGPFLVIAPLSTIPNWQREFETWTD-MNVVV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 776 YYGSP--QQRKEKRKGWNKPDA---------FHVCIVSYQLVVQDQHSFKRKRWQYMVLDEAHNIKNFRSTRWQALLNFN 844
Cdd:cd17995 80 YHGSGesRQIIQQYEMYFKDAQgrkkkgvykFDVLITTYEMVIADAEELRKIPWRVVVVDEAHRLKNRNSKLLQGLKKLT 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 845 TQRRLLLTGTPLQNNLAELWSLLYFLMPQTvidgkkvsgFADLDAFQQWFGrpvdkiietgqnfgqDKETKKTVAKLHQV 924
Cdd:cd17995 160 LEHKLLLTGTPLQNNTEELWSLLNFLEPEK---------FPSSEEFLEEFG---------------DLKTAEQVEKLQAL 215
|
....*...
gi 6320541 925 LRPYLLRR 932
Cdd:cd17995 216 LKPYMLRR 223
|
|
| DEXHc_SMARCA2 |
cd18063 |
DEXH-box helicase domain of SMARCA2; SWI/SNF related, matrix associated, actin dependent ... |
691-934 |
5.25e-62 |
|
DEXH-box helicase domain of SMARCA2; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 (SMARCA2, also known as brahma homolog) is a component of the BAF complex. SMARCA2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350821 [Multi-domain] Cd Length: 251 Bit Score: 212.62 E-value: 5.25e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 691 LLRGNLRTYQKQGLNWLASLYNNHTNGILADEMGLGKTIQTISLLAYLACEKENWGPHLIVVPTSVLLNWEMEFKRFAPG 770
Cdd:cd18063 19 LINGTLKHYQLQGLEWMVSLYNNNLNGILADEMGLGKTIQTIALITYLMEHKRLNGPYLIIVPLSTLSNWTYEFDKWAPS 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 771 FKVLTYYGSPQQRK----EKRKGwnkpdAFHVCIVSYQLVVQDQHSFKRKRWQYMVLDEAHNIKNFRSTRWQAL-LNFNT 845
Cdd:cd18063 99 VVKISYKGTPAMRRslvpQLRSG-----KFNVLLTTYEYIIKDKHILAKIRWKYMIVDEGHRMKNHHCKLTQVLnTHYVA 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 846 QRRLLLTGTPLQNNLAELWSLLYFLMPQTvidgkkvsgFADLDAFQQWFGRPvdkIIETGQNFG-QDKETKKTVAKLHQV 924
Cdd:cd18063 174 PRRILLTGTPLQNKLPELWALLNFLLPTI---------FKSCSTFEQWFNAP---FAMTGERVDlNEEETILIIRRLHKV 241
|
250
....*....|
gi 6320541 925 LRPYLLRRLK 934
Cdd:cd18063 242 LRPFLLRRLK 251
|
|
| DEXHc_SMARCA1 |
cd18065 |
DEAH-box helicase domain of SMARCA1; SWI/SNF related, matrix associated, actin dependent ... |
689-934 |
1.72e-61 |
|
DEAH-box helicase domain of SMARCA1; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 (SMARCA1, also called SNF2L) is a component of NURF (nucleosome-remodeling factor) and CERF (CECR2-containing-remodeling factor) complexes which promote the perturbation of chromatin structure in an ATP-dependent manner. SMARCA1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350823 [Multi-domain] Cd Length: 233 Bit Score: 210.26 E-value: 1.72e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 689 PSLLRGN-LRTYQKQGLNWLASLYNNHTNGILADEMGLGKTIQTISLLAYLACEKENWGPHLIVVPTSVLLNWEMEFKRF 767
Cdd:cd18065 8 PSYVKGGtLRDYQVRGLNWMISLYENGVNGILADEMGLGKTLQTIALLGYLKHYRNIPGPHMVLVPKSTLHNWMNEFKRW 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 768 APGFKVLTYYGSPQQRKEKRKGWNKPDAFHVCIVSYQLVVQDQHSFKRKRWQYMVLDEAHNIKNFRSTRWQALLNFNTQR 847
Cdd:cd18065 88 VPSLRAVCLIGDKDARAAFIRDVMMPGEWDVCVTSYEMVIKEKSVFKKFNWRYLVIDEAHRIKNEKSKLSEIVREFKTTN 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 848 RLLLTGTPLQNNLAELWSLLYFLMPQTvidgkkvsgFADLDAFQQWFgrpvdkiiETGQNFGQdketKKTVAKLHQVLRP 927
Cdd:cd18065 168 RLLLTGTPLQNNLHELWALLNFLLPDV---------FNSADDFDSWF--------DTKNCLGD----QKLVERLHAVLKP 226
|
....*..
gi 6320541 928 YLLRRLK 934
Cdd:cd18065 227 FLLRRIK 233
|
|
| DEXHc_SMARCA4 |
cd18062 |
DEXH-box helicase domain of SMARCA4; SWI/SNF related, matrix associated, actin dependent ... |
691-934 |
1.65e-60 |
|
DEXH-box helicase domain of SMARCA4; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 (SMARCA4, also known as transcription activator BRG1) is a component of the CREST-BRG1 complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. Mutation of SMARCA4 (BRG1), the ATPase of BAF (mSWI/SNF) and PBAF complexes, contributes to a range of malignancies and neurologic disorders. SMARCA4 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350820 [Multi-domain] Cd Length: 251 Bit Score: 208.36 E-value: 1.65e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 691 LLRGNLRTYQKQGLNWLASLYNNHTNGILADEMGLGKTIQTISLLAYLACEKENWGPHLIVVPTSVLLNWEMEFKRFAPG 770
Cdd:cd18062 19 LVNGVLKQYQIKGLEWLVSLYNNNLNGILADEMGLGKTIQTIALITYLMEHKRINGPFLIIVPLSTLSNWVYEFDKWAPS 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 771 FKVLTYYGSPQQRK----EKRKGwnkpdAFHVCIVSYQLVVQDQHSFKRKRWQYMVLDEAHNIKNFRSTRWQAL-LNFNT 845
Cdd:cd18062 99 VVKVSYKGSPAARRafvpQLRSG-----KFNVLLTTYEYIIKDKQILAKIRWKYMIVDEGHRMKNHHCKLTQVLnTHYVA 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 846 QRRLLLTGTPLQNNLAELWSLLYFLMPQTvidgkkvsgFADLDAFQQWFGRPvdkIIETGQNFG-QDKETKKTVAKLHQV 924
Cdd:cd18062 174 PRRLLLTGTPLQNKLPELWALLNFLLPTI---------FKSCSTFEQWFNAP---FAMTGEKVDlNEEETILIIRRLHKV 241
|
250
....*....|
gi 6320541 925 LRPYLLRRLK 934
Cdd:cd18062 242 LRPFLLRRLK 251
|
|
| DEXHc_CHD1L |
cd18006 |
DEAH/Q-box helicase domain of CHD1L; Chromodomain helicase DNA binding protein 1 like (CHD1L, ... |
696-932 |
3.44e-60 |
|
DEAH/Q-box helicase domain of CHD1L; Chromodomain helicase DNA binding protein 1 like (CHD1L, also known as ALC1) is involved in DNA repair by regulating chromatin relaxation following DNA damage. CHD1L is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350764 [Multi-domain] Cd Length: 216 Bit Score: 205.75 E-value: 3.44e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 696 LRTYQKQGLNWLASLYNNHTNGILADEMGLGKTIQTISLLAYLACEKENWGPHLIVVPTSVLLNWEMEFKRFAPGFKVLT 775
Cdd:cd18006 1 LRPYQLEGVNWLLQCRAEQHGCILGDEMGLGKTCQTISLLWYLAGRLKLLGPFLVLCPLSVLDNWKEELNRFAPDLSVIT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 776 YYGSPQQRKEKRKGWNKPDAFHVCIVSYQLVVQDQHSFKRKRWQYMVLDEAHNIKNFRSTRWQALLNFNTQRRLLLTGTP 855
Cdd:cd18006 81 YMGDKEKRLDLQQDIKSTNRFHVLLTTYEICLKDASFLKSFPWASLVVDEAHRLKNQNSLLHKTLSEFSVDFRLLLTGTP 160
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 6320541 856 LQNNLAELWSLLYFLMPqtvidgkkvsgfadlDAFqqwfgrPVDKIIETGQNFGQDKETKKTVAKLHQVLRPYLLRR 932
Cdd:cd18006 161 IQNSLQELYALLSFIEP---------------NVF------PKDKLDDFIKAYSETDDESETVEELHLLLQPFLLRR 216
|
|
| SF2_C_SNF |
cd18793 |
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) ... |
1235-1370 |
4.27e-59 |
|
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) family includes chromatin-remodeling factors, such as CHD proteins and SMARCA proteins, recombination proteins Rad54, and many others. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350180 [Multi-domain] Cd Length: 135 Bit Score: 199.24 E-value: 4.27e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 1235 FPDKSLLQYDcGKLQKLAILLQQLKDNGHRALIFTQMTKVLDVLEQFLNYHGYLYMRLDGATKIEDRQILTERFNTDSRI 1314
Cdd:cd18793 1 LPPKIEEVVS-GKLEALLELLEELREPGEKVLIFSQFTDTLDILEEALRERGIKYLRLDGSTSSKERQKLVDRFNEDPDI 79
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 6320541 1315 TVFILSSRSGGLGINLTGADTVIFYDSDWNPAMDKQCQDRCHRIGQTRDVHIYRFV 1370
Cdd:cd18793 80 RVFLLSTKAGGVGLNLTAANRVILYDPWWNPAVEEQAIDRAHRIGQKKPVVVYRLI 135
|
|
| DEXHc_Mot1 |
cd17999 |
DEXH-box helicase domain of Mot1; Modifier of transcription 1 (Mot1, also known as TAF172 in ... |
696-932 |
4.68e-57 |
|
DEXH-box helicase domain of Mot1; Modifier of transcription 1 (Mot1, also known as TAF172 in eukaryotes) regulates transcription in association with TATA binding protein (TBP). Mot1, Ino80C, and NC2 function coordinately to regulate pervasive transcription in yeast and mammals. Mot1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350757 [Multi-domain] Cd Length: 232 Bit Score: 197.57 E-value: 4.68e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 696 LRTYQKQGLNWLASLYNNHTNGILADEMGLGKTIQTISLLAYLACEKENWG-----PHLIVVPTSVLLNWEMEFKRFAPG 770
Cdd:cd17999 1 LRPYQQEGINWLAFLNKYNLHGILCDDMGLGKTLQTLCILASDHHKRANSFnsenlPSLVVCPPTLVGHWVAEIKKYFPN 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 771 F--KVLTYYGSPQQRKEKRKGWNKPDafhVCIVSYQLVVQDQHSFKRKRWQYMVLDEAHNIKNFRSTRWQALLNFNTQRR 848
Cdd:cd17999 81 AflKPLAYVGPPQERRRLREQGEKHN---VIVASYDVLRNDIEVLTKIEWNYCVLDEGHIIKNSKTKLSKAVKQLKANHR 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 849 LLLTGTPLQNNLAELWSLLYFLMPqtvidgkkvsGF-ADLDAFQQWFGRPVDKIIETGQNFGQDKETKKTVAKLH-QVLr 926
Cdd:cd17999 158 LILSGTPIQNNVLELWSLFDFLMP----------GYlGTEKQFQRRFLKPILASRDSKASAKEQEAGALALEALHkQVL- 226
|
....*.
gi 6320541 927 PYLLRR 932
Cdd:cd17999 227 PFLLRR 232
|
|
| DEXHc_CHD2 |
cd18054 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 2; ... |
689-932 |
1.40e-55 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 2; Chromodomain-helicase-DNA-binding protein 2 (CHD2) is a DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. It is involved in myogenesis via interaction with MYOD1; it binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression. CHD2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350812 [Multi-domain] Cd Length: 237 Bit Score: 193.30 E-value: 1.40e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 689 PSLLRGN---LRTYQKQGLNWLASLYNNHTNGILADEMGLGKTIQTISLLAYLACEKENWGPHLIVVPTSVLLNWEMEFK 765
Cdd:cd18054 11 PSYIGGEnleLRDYQLEGLNWLAHSWCKNNSVILADEMGLGKTIQTISFLSYLFHQHQLYGPFLLVVPLSTLTSWQREFE 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 766 RFAPGFKVLTYYGSPQQRKEKRK-GWNKPDA----FHVCIVSYQLVVQDQHSFKRKRWQYMVLDEAHNIKNFRSTRWQAL 840
Cdd:cd18054 91 IWAPEINVVVYIGDLMSRNTIREyEWIHSQTkrlkFNALITTYEILLKDKTVLGSINWAFLGVDEAHRLKNDDSLLYKTL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 841 LNFNTQRRLLLTGTPLQNNLAELWSLLYFLMPqtvidgkkvsgfadlDAFQQWfgrpvdkiietgQNFGQD--KETKKTV 918
Cdd:cd18054 171 IDFKSNHRLLITGTPLQNSLKELWSLLHFIMP---------------EKFEFW------------EDFEEDhgKGRENGY 223
|
250
....*....|....
gi 6320541 919 AKLHQVLRPYLLRR 932
Cdd:cd18054 224 QSLHKVLEPFLLRR 237
|
|
| DEXHc_ERCC6L |
cd18001 |
DEXH-box helicase domain of ERCC6L; ERCC excision repair 6 like, spindle assembly checkpoint ... |
699-932 |
1.22e-52 |
|
DEXH-box helicase domain of ERCC6L; ERCC excision repair 6 like, spindle assembly checkpoint helicase (ERCC6L, also known as RAD26L) is an essential component of the mitotic spindle assembly checkpoint, by acting as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase. ERCC6L is proposed to stimulate cancer cell proliferation by promoting cell cycle through a way of RAB31-MAPK-CDK2. ERCC6L is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350759 [Multi-domain] Cd Length: 232 Bit Score: 184.88 E-value: 1.22e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 699 YQKQGLNWLASLYNNHTNGILADEMGLGKTIQTISLLAYLAcEKENWGPHLIVVPTSVLLNWEMEFKRFAPGFKVLTYYG 778
Cdd:cd18001 4 HQREGVAWLWSLHDGGKGGILADDMGLGKTVQICAFLSGMF-DSGLIKSVLVVMPTSLIPHWVKEFAKWTPGLRVKVFHG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 779 SpqQRKEKRKGWNK-PDAFHVCIVSYQLVV---QDQHSFKRK--RWQYMVLDEAHNIKNFRSTRWQALLNFNTQRRLLLT 852
Cdd:cd18001 83 T--SKKERERNLERiQRGGGVLLTTYGMVLsntEQLSADDHDefKWDYVILDEGHKIKNSKTKSAKSLREIPAKNRIILT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 853 GTPLQNNLAELWSLLYFLMPQTVIDGKKvsgfadldAFQQWFGRPVDKIIETGQNFGQDKETKKTVAKLHQVLRPYLLRR 932
Cdd:cd18001 161 GTPIQNNLKELWALFDFACNGSLLGTRK--------TFKMEFENPITRGRDKDATQGEKALGSEVAENLRQIIKPYFLRR 232
|
|
| DEXHc_CHD3_4_5 |
cd17994 |
DEAH-box helicase domain of the chromodomain helicase DNA binding proteins 3, 4 and 5; ... |
696-932 |
1.73e-51 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding proteins 3, 4 and 5; Chromodomain-helicase-DNA-binding protein 3 (CHD3) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. It is required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity. Chromodomain-helicase-DNA-binding protein 4 (CHD4) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromodomain-helicase-DNA-binding protein 5 (CHD5) is a chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. It is thought to specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3 and plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. As a tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa. CHD3, CHD4, and CHD5 are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350752 [Multi-domain] Cd Length: 196 Bit Score: 179.94 E-value: 1.73e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 696 LRTYQKQGLNWLASLYNNHTNGILADEMGLGKTIQTISLLAYLACEKENWGPHLIVVPTSVLLNWEMEFKRFAPGFKVLT 775
Cdd:cd17994 1 LHPYQLEGLNWLRFSWAQGTDTILADEMGLGKTIQTIVFLYSLYKEGHSKGPFLVSAPLSTIINWEREFEMWAPDFYVVT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 776 YYGSpqqrkekrkgwnkpdafHVCIVSYQLVVQDQHSFKRKRWQYMVLDEAHNIKNFRSTRWQALLNFNTQRRLLLTGTP 855
Cdd:cd17994 81 YVGD-----------------HVLLTSYELISIDQAILGSIDWAVLVVDEAHRLKNNQSKFFRILNSYKIGYKLLLTGTP 143
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 6320541 856 LQNNLAELWSLLYFLMPQTvidgkkvsgFADLDAFQQWFgrpvdkiietgqnfgQDKETKKTVAKLHQVLRPYLLRR 932
Cdd:cd17994 144 LQNNLEELFHLLNFLTPER---------FNNLQGFLEEF---------------ADISKEDQIKKLHDLLGPHMLRR 196
|
|
| DEXHc_ERCC6 |
cd18000 |
DEXH-box helicase domain of ERCC6; ERCC excision repair 6, chromatin remodeling factor (ERCC6, ... |
699-872 |
3.49e-48 |
|
DEXH-box helicase domain of ERCC6; ERCC excision repair 6, chromatin remodeling factor (ERCC6, also known Cockayne syndrome group B (CSB), Rad26 in Saccharomyces cerevisiae, and Rhp26 in Schizosaccharomyces pombe) is a DNA-binding protein that is important in transcription-coupled excision repair. ERCC6 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350758 [Multi-domain] Cd Length: 193 Bit Score: 170.58 E-value: 3.49e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 699 YQKQGLNWLASLYNNHTNGILADEMGLGKTIQTISLLAYLACEKENWGPHLIVVPTSVLLNWEMEFKRFAPGFKVLTYYG 778
Cdd:cd18000 4 YQQTGVQWLWELHCQRVGGILGDEMGLGKTIQIIAFLAALHHSKLGLGPSLIVCPATVLKQWVKEFHRWWPPFRVVVLHS 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 779 SPQQRKEKRKGWNKPDAF----------HVCIVSYQLVVQDQHSFKRKRWQYMVLDEAHNIKNFRSTRWQALLNFNTQRR 848
Cdd:cd18000 84 SGSGTGSEEKLGSIERKSqlirkvvgdgGILITTYEGFRKHKDLLLNHNWQYVILDEGHKIRNPDAEITLACKQLRTPHR 163
|
170 180
....*....|....*....|....
gi 6320541 849 LLLTGTPLQNNLAELWSLLYFLMP 872
Cdd:cd18000 164 LILSGTPIQNNLKELWSLFDFVFP 187
|
|
| PLN03142 |
PLN03142 |
Probable chromatin-remodeling complex ATPase chain; Provisional |
1246-1452 |
8.03e-47 |
|
Probable chromatin-remodeling complex ATPase chain; Provisional
Pssm-ID: 215601 [Multi-domain] Cd Length: 1033 Bit Score: 183.85 E-value: 8.03e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 1246 GKLQKLAILLQQLKDNGHRALIFTQMTKVLDVLEQFLNYHGYLYMRLDGATKIEDRQILTERFNTD-SRITVFILSSRSG 1324
Cdd:PLN03142 471 GKMVLLDKLLPKLKERDSRVLIFSQMTRLLDILEDYLMYRGYQYCRIDGNTGGEDRDASIDAFNKPgSEKFVFLLSTRAG 550
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 1325 GLGINLTGADTVIFYDSDWNPAMDKQCQDRCHRIGQTRDVHIYRFVSEHTIESNILKKANQKRQLDNVVIQEGDFTTDyf 1404
Cdd:PLN03142 551 GLGINLATADIVILYDSDWNPQVDLQAQDRAHRIGQKKEVQVFRFCTEYTIEEKVIERAYKKLALDALVIQQGRLAEQ-- 628
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 6320541 1405 SKLSVRDLL-----GSELpenASGGDKPLIADADVaakdprqlERLLAQAEDE 1452
Cdd:PLN03142 629 KTVNKDELLqmvryGAEM---VFSSKDSTITDEDI--------DRIIAKGEEA 670
|
|
| DEXDc_SHPRH-like |
cd18008 |
DEXH-box helicase domain of SHPRH-like proteins; The SHPRH-like subgroup belongs to the ... |
696-932 |
2.61e-46 |
|
DEXH-box helicase domain of SHPRH-like proteins; The SHPRH-like subgroup belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350766 [Multi-domain] Cd Length: 241 Bit Score: 167.08 E-value: 2.61e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 696 LRTYQKQGLNWLaslynNHTNGILADEMGLGKTIQTISLLA---------------YLACEKENWGPH--LIVVPTSVLL 758
Cdd:cd18008 1 LLPYQKQGLAWM-----LPRGGILADEMGLGKTIQALALILatrpqdpkipeeleeNSSDPKKLYLSKttLIVVPLSLLS 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 759 NWEMEFKRF--APGFKVLTYYGSpqQRKEKRKGWNKPDafhVCIVSYQLVVQDQHSFKRK----------------RWQY 820
Cdd:cd18008 76 QWKDEIEKHtkPGSLKVYVYHGS--KRIKSIEELSDYD---IVITTYGTLASEFPKNKKGggrdskekeasplhriRWYR 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 821 MVLDEAHNIKNFRSTRWQALLNFNTQRRLLLTGTPLQNNLAELWSLLYFLmpqtvidgkKVSGFADLDAFQQWFGRPVdk 900
Cdd:cd18008 151 VILDEAHNIKNRSTKTSRAVCALKAERRWCLTGTPIQNSLDDLYSLLRFL---------RVEPFGDYPWFNSDISKPF-- 219
|
250 260 270
....*....|....*....|....*....|..
gi 6320541 901 iietgqnfgqDKETKKTVAKLHQVLRPYLLRR 932
Cdd:cd18008 220 ----------SKNDRKALERLQALLKPILLRR 241
|
|
| DEXHc_CHD1 |
cd18053 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 1; ... |
696-932 |
7.11e-46 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 1; Chromodomain-helicase-DNA-binding protein 1 (CHD1) is an ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. It regulates polymerase II transcription and is also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. It is not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. CHD1 is also associated with histone deacetylase (HDAC) activity. It is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350811 [Multi-domain] Cd Length: 237 Bit Score: 165.61 E-value: 7.11e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 696 LRTYQKQGLNWLASLYNNHTNGILADEMGLGKTIQTISLLAYLACEKENWGPHLIVVPTSVLLNWEMEFKRFAPGFKVLT 775
Cdd:cd18053 21 LRDYQLNGLNWLAHSWCKGNSCILADEMGLGKTIQTISFLNYLFHEHQLYGPFLLVVPLSTLTSWQREIQTWAPQMNAVV 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 776 YYGSPQQRKEKRKG-WNKPDA----FHVCIVSYQLVVQDQHSFKRKRWQYMVLDEAHNIKNFRSTRWQALLNFNTQRRLL 850
Cdd:cd18053 101 YLGDINSRNMIRTHeWMHPQTkrlkFNILLTTYEILLKDKSFLGGLNWAFIGVDEAHRLKNDDSLLYKTLIDFKSNHRLL 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 851 LTGTPLQNNLAELWSLLYFLMPQTvidgkkvsgFADLDAFQQWFGRpvdkiietGQNFGqdketkktVAKLHQVLRPYLL 930
Cdd:cd18053 181 ITGTPLQNSLKELWSLLHFIMPEK---------FSSWEDFEEEHGK--------GREYG--------YASLHKELEPFLL 235
|
..
gi 6320541 931 RR 932
Cdd:cd18053 236 RR 237
|
|
| DEXHc_CHD3 |
cd18055 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 3; ... |
696-932 |
9.27e-45 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 3; Chromodomain-helicase-DNA-binding protein 3 (CHD3) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. It is required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity. CHD3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350813 [Multi-domain] Cd Length: 232 Bit Score: 162.10 E-value: 9.27e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 696 LRTYQKQGLNWLASLYNNHTNGILADEMGLGKTIQTISLLAYLACEKENWGPHLIVVPTSVLLNWEMEFKRFAPGFKVLT 775
Cdd:cd18055 1 LHMYQLEGLNWLRFSWAQGTDTILADEMGLGKTIQTIVFLYSLYKEGHTKGPFLVSAPLSTIINWEREFQMWAPDFYVVT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 776 YYGSPQQRKEKR-----------KGWNK--------PDAFHVCIVSYQLVVQDQHSFKRKRWQYMVLDEAHNIKNFRSTR 836
Cdd:cd18055 81 YTGDKDSRAIIRenefsfddnavKGGKKafkmkreaQVKFHVLLTSYELVTIDQAALGSIRWACLVVDEAHRLKNNQSKF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 837 WQALLNFNTQRRLLLTGTPLQNNLAELWSLLYFLMPQTvidgkkvsgFADLDAFQQWFGrpvdkiietgqnfgqDKETKK 916
Cdd:cd18055 161 FRVLNGYKIDHKLLLTGTPLQNNLEELFHLLNFLTPER---------FNNLEGFLEEFA---------------DISKED 216
|
250
....*....|....*.
gi 6320541 917 TVAKLHQVLRPYLLRR 932
Cdd:cd18055 217 QIKKLHDLLGPHMLRR 232
|
|
| DEXHc_ERCC6L2 |
cd18005 |
DEXH-box helicase domain of ERCC6L2; ERCC excision repair 6 like 2 (ERCC6L2, also known as ... |
696-932 |
1.65e-43 |
|
DEXH-box helicase domain of ERCC6L2; ERCC excision repair 6 like 2 (ERCC6L2, also known as RAD26L) may play a role in DNA repair and mitochondrial function. In humans, mutations in the ERCC6L2 gene are associated with bone marrow failure syndrome 2. ERCC6L2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350763 [Multi-domain] Cd Length: 245 Bit Score: 159.08 E-value: 1.65e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 696 LRTYQKQGLNWLASLYNNHTNGILADEMGLGKTIQTISLLA------YLACEKEN--------------WGPHLIVVPTS 755
Cdd:cd18005 1 LRDYQREGVEFMYDLYKNGRGGILGDDMGLGKTVQVIAFLAavlgktGTRRDRENnrprfkkkppassaKKPVLIVAPLS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 756 VLLNWEMEFKRFApGFKVLTYYGSpqQRKEKRKGWNKPDAFHVCIVSYQLVVQDQHSFKRKRWQYMVLDEAHNIKNFRST 835
Cdd:cd18005 81 VLYNWKDELDTWG-HFEVGVYHGS--RKDDELEGRLKAGRLEVVVTTYDTLRRCIDSLNSINWSAVIADEAHRIKNPKSK 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 836 RWQALLNFNTQRRLLLTGTPLQNNLAELWSLLYFLMPQTVidgkkvsgfADLDAFQQWFGRPvdkiIETGQNFGQDKE-- 913
Cdd:cd18005 158 LTQAMKELKCKVRIGLTGTLLQNNMKELWCLLDWAVPGAL---------GSRSQFKKHFSEP----IKRGQRHTATARel 224
|
250 260
....*....|....*....|.
gi 6320541 914 --TKKTVAKLHQVLRPYLLRR 932
Cdd:cd18005 225 rlGRKRKQELAVKLSKFFLRR 245
|
|
| DEXHc_CHD5 |
cd18057 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 5; ... |
696-932 |
1.32e-41 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 5; Chromodomain-helicase-DNA-binding protein 5 (CHD5) is a chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. It is thought to specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3 and plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. As a tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa. CHD5 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350815 [Multi-domain] Cd Length: 232 Bit Score: 153.30 E-value: 1.32e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 696 LRTYQKQGLNWLASLYNNHTNGILADEMGLGKTIQTISLLAYLACEKENWGPHLIVVPTSVLLNWEMEFKRFAPGFKVLT 775
Cdd:cd18057 1 LHPYQLEGLNWLRFSWAQGTDTILADEMGLGKTVQTIVFLYSLYKEGHSKGPYLVSAPLSTIINWEREFEMWAPDFYVVT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 776 YYGSPQQRKEKRKG----------------WNKPDA---FHVCIVSYQLVVQDQHSFKRKRWQYMVLDEAHNIKNFRSTR 836
Cdd:cd18057 81 YTGDKESRSVIRENefsfednairsgkkvfRMKKEAqikFHVLLTSYELITIDQAILGSIEWACLVVDEAHRLKNNQSKF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 837 WQALLNFNTQRRLLLTGTPLQNNLAELWSLLYFLMPQTvidgkkvsgFADLDAFQQWFGrpvdkiietgqnfgqDKETKK 916
Cdd:cd18057 161 FRVLNSYKIDYKLLLTGTPLQNNLEELFHLLNFLTPER---------FNNLEGFLEEFA---------------DISKED 216
|
250
....*....|....*.
gi 6320541 917 TVAKLHQVLRPYLLRR 932
Cdd:cd18057 217 QIKKLHDLLGPHMLRR 232
|
|
| DEXHc_CHD4 |
cd18056 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 4; ... |
696-932 |
7.09e-40 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 4; Chromodomain-helicase-DNA-binding protein 4 (CHD4) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. CHD4 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350814 [Multi-domain] Cd Length: 232 Bit Score: 148.29 E-value: 7.09e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 696 LRTYQKQGLNWLASLYNNHTNGILADEMGLGKTIQTISLLAYLACEKENWGPHLIVVPTSVLLNWEMEFKRFAPGFKVLT 775
Cdd:cd18056 1 LHPYQLEGLNWLRFSWAQGTDTILADEMGLGKTVQTAVFLYSLYKEGHSKGPFLVSAPLSTIINWEREFEMWAPDMYVVT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 776 YYGSPQQR-------------------KEKRKGWNKPDAFHVCIVSYQLVVQDQHSFKRKRWQYMVLDEAHNIKNFRSTR 836
Cdd:cd18056 81 YVGDKDSRaiirenefsfednairggkKASRMKKEASVKFHVLLTSYELITIDMAILGSIDWACLIVDEAHRLKNNQSKF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 837 WQALLNFNTQRRLLLTGTPLQNNLAELWSLLYFLMPQTvidgkkvsgFADLDAFQQWFGrpvdkiietgqnfgqDKETKK 916
Cdd:cd18056 161 FRVLNGYSLQHKLLLTGTPLQNNLEELFHLLNFLTPER---------FHNLEGFLEEFA---------------DIAKED 216
|
250
....*....|....*.
gi 6320541 917 TVAKLHQVLRPYLLRR 932
Cdd:cd18056 217 QIKKLHDMLGPHMLRR 232
|
|
| DEXHc_CHD6 |
cd18058 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 6; ... |
696-932 |
4.08e-39 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 6; Chromodomain-helicase-DNA-binding protein 6 (CHD6) is a DNA-dependent ATPase that plays a role in chromatin remodeling. It regulates transcription by disrupting nucleosomes in a largely non-sliding manner which strongly increases the accessibility of chromatin. It activates transcription of specific genes in response to oxidative stress through interaction with NFE2L2.2 and acts as a transcriptional repressor of different viruses including influenza virus or papillomavirus. During influenza virus infection, the viral polymerase complex localizes CHD6 to inactive chromatin where it gets degraded in a proteasome independent-manner. CHD6 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350816 [Multi-domain] Cd Length: 222 Bit Score: 145.57 E-value: 4.08e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 696 LRTYQKQGLNWLASLYNNHTNGILADEMGLGKTIQTISLLAYLACEKENwGPHLIVVPTSVLLNWEMEFKRFAPgFKVLT 775
Cdd:cd18058 1 LREYQLEGMNWLLFNWYNRKNCILADEMGLGKTIQSITFLSEIFLMGIR-GPFLIIAPLSTITNWEREFRTWTE-MNAIV 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 776 YYGSPQQRKE-------KRKGWNKPDA----FHVCIVSYQLVVQDQHSFKRKRWQYMVLDEAHNIKNFRSTRWQALLNFN 844
Cdd:cd18058 79 YHGSQISRQMiqqyemyYRDEQGNPLSgifkFQVVITTFEMILADCPELKKINWSCVIIDEAHRLKNRNCKLLEGLKLMA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 845 TQRRLLLTGTPLQNNLAELWSLLYFLMPqtvidgkkvSGFADLDAFQQWFGrpvdkiietgqnfgqDKETKKTVAKLHQV 924
Cdd:cd18058 159 LEHKVLLTGTPLQNSVEELFSLLNFLEP---------SQFPSETTFLEEFG---------------DLKTEEQVKKLQSI 214
|
....*...
gi 6320541 925 LRPYLLRR 932
Cdd:cd18058 215 LKPMMLRR 222
|
|
| DEXHc_RAD54 |
cd18004 |
DEXH-box helicase domain of RAD54; RAD54 proteins play a role in recombination. They are ... |
696-932 |
2.04e-36 |
|
DEXH-box helicase domain of RAD54; RAD54 proteins play a role in recombination. They are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350762 [Multi-domain] Cd Length: 240 Bit Score: 138.57 E-value: 2.04e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 696 LRTYQKQGLNWL--ASLYNNHTNG---ILADEMGLGKTIQTISLLAYLACEKENWGPH----LIVVPTSVLLNWEMEFKR 766
Cdd:cd18004 1 LRPHQREGVQFLydCLTGRRGYGGggaILADEMGLGKTLQAIALVWTLLKQGPYGKPTakkaLIVCPSSLVGNWKAEFDK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 767 FAPG--FKVLTYYGSPQQRKEKRKGWNKPDAFHVCIVSYQLVVQdqHS---FKRKRWQYMVLDEAHNIKNFRSTRWQALL 841
Cdd:cd18004 81 WLGLrrIKVVTADGNAKDVKASLDFFSSASTYPVLIISYETLRR--HAeklSKKISIDLLICDEGHRLKNSESKTTKALN 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 842 NFNTQRRLLLTGTPLQNNLAELWSLLYFLMPqtvidgkkvSGFADLDAFQQWFGRPVDKIIETGQNFGQDKETKKTVAKL 921
Cdd:cd18004 159 SLPCRRRLLLTGTPIQNDLDEFFALVDFVNP---------GILGSLASFRKVFEEPILRSRDPDASEEDKELGAERSQEL 229
|
250
....*....|.
gi 6320541 922 HQVLRPYLLRR 932
Cdd:cd18004 230 SELTSRFILRR 240
|
|
| DEXHc_CHD8 |
cd18060 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 8; ... |
696-932 |
2.18e-36 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 8; Chromodomain-helicase-DNA-binding protein 8 (CHD8) is a DNA helicase that acts as a chromatin remodeling factor and regulates transcription. It also acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. It suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity and of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. It also acts as a negative regulator of Wnt signaling pathway and CTNNB1-targeted gene expression. CHD8 is also involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. It also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription. CHD8 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350818 [Multi-domain] Cd Length: 222 Bit Score: 137.88 E-value: 2.18e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 696 LRTYQKQGLNWLASLYNNHTNGILADEMGLGKTIQTISLLAYLACEKENwGPHLIVVPTSVLLNWEMEFKRFAPgFKVLT 775
Cdd:cd18060 1 LREYQLEGVNWLLFNWYNRQNCILADEMGLGKTIQSIAFLQEVYNVGIH-GPFLVIAPLSTITNWEREFNTWTE-MNTIV 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 776 YYGSPQQRK---------EKRKGWNKPDA--FHVCIVSYQLVVQDQHSFKRKRWQYMVLDEAHNIKNFRSTRWQALLNFN 844
Cdd:cd18060 79 YHGSLASRQmiqqyemycKDSRGRLIPGAykFDALITTFEMILSDCPELREIEWRCVIIDEAHRLKNRNCKLLDSLKHMD 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 845 TQRRLLLTGTPLQNNLAELWSLLYFLMPqtvidgkkvSGFADLDAFQQWFGrpvdkiietgqnfgqDKETKKTVAKLHQV 924
Cdd:cd18060 159 LEHKVLLTGTPLQNTVEELFSLLHFLEP---------SQFPSESEFLKDFG---------------DLKTEEQVQKLQAI 214
|
....*...
gi 6320541 925 LRPYLLRR 932
Cdd:cd18060 215 LKPMMLRR 222
|
|
| DEXHc_CHD7 |
cd18059 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 7; ... |
696-932 |
2.72e-36 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 7; Chromodomain-helicase-DNA-binding protein 7 (CHD7) is a probable transcription regulator. It may be involved in the 45S precursor rRNA production. CHD7 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350817 [Multi-domain] Cd Length: 222 Bit Score: 137.47 E-value: 2.72e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 696 LRTYQKQGLNWLASLYNNHTNGILADEMGLGKTIQTISLLaYLACEKENWGPHLIVVPTSVLLNWEMEFKRFAPgFKVLT 775
Cdd:cd18059 1 LREYQLEGVNWLLFNWYNTRNCILADEMGLGKTIQSITFL-YEIYLKGIHGPFLVIAPLSTIPNWEREFRTWTE-LNVVV 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 776 YYGSPQQRKEKR--------------KGWNKpdaFHVCIVSYQLVVQDQHSFKRKRWQYMVLDEAHNIKNFRSTRWQALL 841
Cdd:cd18059 79 YHGSQASRRTIQlyemyfkdpqgrviKGSYK---FHAIITTFEMILTDCPELRNIPWRCVVIDEAHRLKNRNCKLLEGLK 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 842 NFNTQRRLLLTGTPLQNNLAELWSLLYFLMPQTvidgkkvsgFADLDAFQQWFGrpvdkiietgqnfgqDKETKKTVAKL 921
Cdd:cd18059 156 MMDLEHKVLLTGTPLQNTVEELFSLLHFLEPSR---------FPSETTFMQEFG---------------DLKTEEQVQKL 211
|
250
....*....|.
gi 6320541 922 HQVLRPYLLRR 932
Cdd:cd18059 212 QAILKPMMLRR 222
|
|
| DEXHc_ATRX-like |
cd18007 |
DEXH-box helicase domain of ATRX-like proteins; This family includes ATRX-like members such as ... |
718-920 |
3.76e-36 |
|
DEXH-box helicase domain of ATRX-like proteins; This family includes ATRX-like members such as transcriptional regulator ATRX (also called alpha thalassemia/mental retardation syndrome X-linked and X-linked nuclear protein or XNP) which is involved in transcriptional regulation and chromatin remodeling, and ARIP4 (also called androgen receptor-interacting protein 4, RAD54 like 2 or RAD54L2) which modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. They are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350765 [Multi-domain] Cd Length: 239 Bit Score: 137.42 E-value: 3.76e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 718 ILADEMGLGKTIQTISLL-AYLACEKENWGPhLIVVPTSVLLNWEMEFKR----FAPGFKVLTYYGS---PQQRKEKRKG 789
Cdd:cd18007 30 ILAHTMGLGKTLQVITFLhTYLAAAPRRSRP-LVLCPASTLYNWEDEFKKwlppDLRPLLVLVSLSAskrADARLRKINK 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 790 WNKPDAfhVCIVSYQL---VVQDQHSFKRKRWQYM-----------VLDEAHNIKNFRSTRWQALLNFNTQRRLLLTGTP 855
Cdd:cd18007 109 WHKEGG--VLLIGYELfrnLASNATTDPRLKQEFIaalldpgpdllVLDEGHRLKNEKSQLSKALSKVKTKRRILLTGTP 186
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 6320541 856 LQNNLAELWSLLYFLMPqtvidgkkvsGFAD-LDAFQQWFGRPvdkiIETGQNFGQDKETKKTVAK 920
Cdd:cd18007 187 LQNNLKEYWTMVDFARP----------KYLGtLKEFKKKFVKP----IEAGQCVDSTEEDVRLMLK 238
|
|
| DEXHc_HLTF1_SMARC3 |
cd18071 |
DEXH-box helicase domain of HLTF1; Helicase like transcription factor (HLTF1, also known as ... |
696-932 |
6.77e-33 |
|
DEXH-box helicase domain of HLTF1; Helicase like transcription factor (HLTF1, also known as HIP116 or SMARCA3) has both helicase and E3 ubiquitin ligase activities and ATP-dependent nucleosome-remodeling activity. HLTF1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350829 [Multi-domain] Cd Length: 239 Bit Score: 128.36 E-value: 6.77e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 696 LRTYQKQGLNWLAS-----------------LYNNHTN------------GILADEMGLGKTIQTISLLAYlacekenwG 746
Cdd:cd18071 1 LLPHQKQALAWMVSrensqdlppfweeavglFLNTITNfsqkkrpelvrgGILADDMGLGKTLTTISLILA--------N 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 747 PHLIVVPTSVLLNWEMEFKR-FAPG-FKVLTYYGSpqqrkEKRKGWNKPDAFHVCIVSYQLVVQD-----QHSFKRKRWQ 819
Cdd:cd18071 73 FTLIVCPLSVLSNWETQFEEhVKPGqLKVYTYHGG-----ERNRDPKLLSKYDIVLTTYNTLASDfgakgDSPLHTINWL 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 820 YMVLDEAHNIKNFRSTRWQALLNFNTQRRLLLTGTPLQNNLAELWSLLYFLmpqtvidgkKVSGFADLDAFQQWFGRPVD 899
Cdd:cd18071 148 RVVLDEGHQIRNPNAQQTKAVLNLSSERRWVLTGTPIQNSPKDLGSLLSFL---------HLKPFSNPEYWRRLIQRPLT 218
|
250 260 270
....*....|....*....|....*....|...
gi 6320541 900 KIIETGqnfgqdketkktVAKLHQVLRPYLLRR 932
Cdd:cd18071 219 MGDPTG------------LKRLQVLMKQITLRR 239
|
|
| DEXHc_CHD9 |
cd18061 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 9; ... |
696-932 |
2.42e-32 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 9; Chromodomain-helicase-DNA-binding protein 9 (CHD9) acts as a transcriptional coactivator for PPARA and possibly other nuclear receptors. It is proposed to be a ATP-dependent chromatin remodeling protein. CHD9 has DNA-dependent ATPase activity and binds to A/T-rich DNA. It also associates with A/T-rich regulatory regions in promoters of genes that participate in the differentiation of progenitors during osteogenesis. CHD9 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350819 [Multi-domain] Cd Length: 222 Bit Score: 126.27 E-value: 2.42e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 696 LRTYQKQGLNWLASLYNNHTNGILADEMGLGKTIQTISLLA--YLACEKenwGPHLIVVPTSVLLNWEMEFKRFApGFKV 773
Cdd:cd18061 1 LREYQLEGLNWLLFNWYNRRNCILADEMGLGKTIQSITFLYeiLLTGIR---GPFLIIAPLSTIANWEREFRTWT-DLNV 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 774 LTYYGSP------QQ-----RKEKRKGWNKPDAFHVCIVSYQLVVQDQHSFKRKRWQYMVLDEAHNIKNFRSTRWQALLN 842
Cdd:cd18061 77 VVYHGSLisrqmiQQyemyfRDSQGRIIRGAYRFQAIITTFEMILGGCPELNAIDWRCVIIDEAHRLKNKNCKLLEGLKL 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 843 FNTQRRLLLTGTPLQNNLAELWSLLYFLMPqtvidgkkvSGFADLDAFQQWFGrpvdkiietgqnfgqDKETKKTVAKLH 922
Cdd:cd18061 157 MNLEHKVLLTGTPLQNTVEELFSLLHFLEP---------LRFPSESTFMQEFG---------------DLKTEEQVQKLQ 212
|
250
....*....|
gi 6320541 923 QVLRPYLLRR 932
Cdd:cd18061 213 AILKPMMLRR 222
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
688-872 |
2.35e-30 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 119.52 E-value: 2.35e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 688 VPSLLRGNLRTYQKQGLNWLaslYNNHTNGILADEMGLGKTIQ-TISLLAYLAceKENWGPHLIVVPTSVLL-NWEMEFK 765
Cdd:smart00487 1 IEKFGFEPLRPYQKEAIEAL---LSGLRDVILAAPTGSGKTLAaLLPALEALK--RGKGGRVLVLVPTRELAeQWAEELK 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 766 RFAP--GFKVLTYYGSPQQRKEKRKgWNKPDaFHVCIVSYQLVVQD--QHSFKRKRWQYMVLDEAHNIKNF-RSTRWQAL 840
Cdd:smart00487 76 KLGPslGLKVVGLYGGDSKREQLRK-LESGK-TDILVTTPGRLLDLleNDKLSLSNVDLVILDEAHRLLDGgFGDQLEKL 153
|
170 180 190
....*....|....*....|....*....|....*..
gi 6320541 841 LNF--NTQRRLLLTGTP---LQNNLAELWSLLYFLMP 872
Cdd:smart00487 154 LKLlpKNVQLLLLSATPpeeIENLLELFLNDPVFIDV 190
|
|
| DEXHc_HARP_SMARCAL1 |
cd18010 |
DEXH-box helicase domain of SMARCAL1; SMARCAL1 (SWI/SNF related, matrix associated, actin ... |
699-873 |
1.16e-29 |
|
DEXH-box helicase domain of SMARCAL1; SMARCAL1 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1, also known as HARP) is recruited to stalled replication forks to promote repair and helps restart replication. It plays a role in DNA repair, telomere maintenance and replication fork stability in response to DNA replication stress. Mutations cause Schimke Immunoosseous Dysplasia. SMARCAL1 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350768 [Multi-domain] Cd Length: 213 Bit Score: 118.08 E-value: 1.16e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 699 YQKQGLNWLASlynnhTNG--ILADEMGLGKTIQTISLLAYLaceKENWgPHLIVVPTSVLLNWEMEFKRFAPGFK---V 773
Cdd:cd18010 4 FQREGVCFALR-----RGGrvLIADEMGLGKTVQAIAIAAYY---REEW-PLLIVCPSSLRLTWADEIERWLPSLPpddI 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 774 LTYYGSpqqRKEKRKGWNKpdafhVCIVSYQLVVQDQHSFKRKRWQYMVLDEAHNIKNFRSTRWQALLNFNTQ--RRLLL 851
Cdd:cd18010 75 QVIVKS---KDGLRDGDAK-----VVIVSYDLLRRLEKQLLARKFKVVICDESHYLKNSKAKRTKAALPLLKRakRVILL 146
|
170 180
....*....|....*....|..
gi 6320541 852 TGTPLQNNLAELWSLLYFLMPQ 873
Cdd:cd18010 147 SGTPALSRPIELFTQLDALDPK 168
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
1249-1359 |
4.04e-26 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 104.21 E-value: 4.04e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 1249 QKLAILLQQLKDN-GHRALIFTQMTKVLDvLEQFLNYHGYLYMRLDGATKIEDRQILTERFNTDSRItvFILSSRSGGLG 1327
Cdd:pfam00271 1 EKLEALLELLKKErGGKVLIFSQTKKTLE-AELLLEKEGIKVARLHGDLSQEEREEILEDFRKGKID--VLVATDVAERG 77
|
90 100 110
....*....|....*....|....*....|..
gi 6320541 1328 INLTGADTVIFYDSDWNPAMDKQCQDRCHRIG 1359
Cdd:pfam00271 78 LDLPDVDLVINYDLPWNPASYIQRIGRAGRAG 109
|
|
| DEXHc_TTF2 |
cd18072 |
DEAH-box helicase domain of TTF2; Transcription termination factor 2 (TTF2 also called ... |
696-932 |
6.64e-26 |
|
DEAH-box helicase domain of TTF2; Transcription termination factor 2 (TTF2 also called Forkhead-box E1/FOXE1 ) is a transcription termination factor that couples ATP hydrolysis with the removal of RNA polymerase II from the DNA template. Single nucleotide polymorphism (SNP) within the 5'-UTR of TTF2 is associated with thyroid cancer risk.TTF2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350830 [Multi-domain] Cd Length: 241 Bit Score: 107.95 E-value: 6.64e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 696 LRTYQKQGLNWLASLYN-NHTNGILADEMGLGKTIQTISLLayLACEK-------------ENWGPH-----------LI 750
Cdd:cd18072 1 LLLHQKQALAWLLWRERqKPRGGILADDMGLGKTLTMIALI--LAQKNtqnrkeeekekalTEWESKkdstlvpsagtLV 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 751 VVPTSVLLNWEMEF-KRFAPG-FKVLTYYGSpqQRKEKRKGWNKPDafhVCIVSYQLVVQDQHSFK---------RKRWQ 819
Cdd:cd18072 79 VCPASLVHQWKNEVeSRVASNkLRVCLYHGP--NRERIGEVLRDYD---IVITTYSLVAKEIPTYKeesrssplfRIAWA 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 820 YMVLDEAHNIKNFRSTRWQALLNFNTQRRLLLTGTPLQNNLAELWSLLYFLmpqtvidgkKVSGFADLDAFQQWFgrpvd 899
Cdd:cd18072 154 RIILDEAHNIKNPKVQASIAVCKLRAHARWALTGTPIQNNLLDMYSLLKFL---------RCSPFDDLKVWKKQV----- 219
|
250 260 270
....*....|....*....|....*....|...
gi 6320541 900 kiietgqnfgqDKETKKTVAKLHQVLRPYLLRR 932
Cdd:cd18072 220 -----------DNKSRKGGERLNILTKSLLLRR 241
|
|
| DEXDc_RapA |
cd18011 |
DEXH-box helicase domain of RapA; In bacteria, RapA is an RNA polymerase (RNAP)-associated ... |
696-892 |
2.27e-25 |
|
DEXH-box helicase domain of RapA; In bacteria, RapA is an RNA polymerase (RNAP)-associated SWI2/SNF2 (switch/sucrose non-fermentable) protein that mediates RNAP recycling during transcription. The ATPase activity of RapA is stimulated by its interaction with RNAP and inhibited by its N-terminal domain. The conformational changes of RapA and its interaction with RNAP are essential for RNAP recycling. RapA is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350769 [Multi-domain] Cd Length: 207 Bit Score: 105.45 E-value: 2.27e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 696 LRTYQKQGLNW-LASLYNNHtngILADEMGLGKTIQTISLLAYLACEkenwGPH---LIVVPTSVLLNWEMEFK-RFAPG 770
Cdd:cd18011 1 PLPHQIDAVLRaLRKPPVRL---LLADEVGLGKTIEAGLIIKELLLR----GDAkrvLILCPASLVEQWQDELQdKFGLP 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 771 FKVLTyygSPQQRKEKRKGWNKPDAFHVCIVSYQLVVQD---QHSFKRKRWQYMVLDEAHNIKNFRSTRWQALLNF---- 843
Cdd:cd18011 74 FLILD---RETAAQLRRLIGNPFEEFPIVIVSLDLLKRSeerRGLLLSEEWDLVVVDEAHKLRNSGGGKETKRYKLgrll 150
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 6320541 844 --NTQRRLLLTGTPLQNNLAELWSLLYFLMPQTvidgkkvsgFADLDAFQQ 892
Cdd:cd18011 151 akRARHVLLLTATPHNGKEEDFRALLSLLDPGR---------FAVLGRFLR 192
|
|
| DEXHc_RAD54B |
cd18066 |
DEXH-box helicase domain of RAD54B; DNA repair and recombination protein RAD54B, also known as ... |
696-932 |
1.00e-24 |
|
DEXH-box helicase domain of RAD54B; DNA repair and recombination protein RAD54B, also known as RDH54, binds to double-stranded DNA, displays ATPase activity in the presence of DNA, and may have a role in meiotic and mitotic recombination. RAD54B is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350824 [Multi-domain] Cd Length: 235 Bit Score: 104.54 E-value: 1.00e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 696 LRTYQKQGLNWL-----ASLYNNHTNGILADEMGLGKTIQTISLLAYLACEkenwGPH---------LIVVPTSVLLNWE 761
Cdd:cd18066 1 LRPHQREGIEFLyecvmGMRVNERFGAILADEMGLGKTLQCISLIWTLLRQ----GPYggkpvikraLIVTPGSLVKNWK 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 762 MEFKRF--APGFKVLTYygspQQRKEKRKGWNKPdAFHVCIVSYQLVVQDQHSFKRKRWQYMVLDEAHNIKNFRSTRWQA 839
Cdd:cd18066 77 KEFQKWlgSERIKVFTV----DQDHKVEEFIASP-LYSVLIISYEMLLRSLDQISKLNFDLVICDEGHRLKNTSIKTTTA 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 840 LLNFNTQRRLLLTGTPLQNNLAELWSLLYFLMPQTVidgkkvsgfADLDAFQQWFGRPvdkIIETGQNFGQDKETK---K 916
Cdd:cd18066 152 LTSLSCERRIILTGTPIQNDLQEFFALIDFVNPGIL---------GSLSTYRKVYEEP---IVRSREPTATPEEKKlgeA 219
|
250
....*....|....*.
gi 6320541 917 TVAKLHQVLRPYLLRR 932
Cdd:cd18066 220 RAAELTRLTGLFILRR 235
|
|
| DEXHc_ATRX |
cd18068 |
DEXH-box helicase domain of ATRX; Transcriptional regulator ATRX (also called alpha ... |
717-872 |
3.05e-23 |
|
DEXH-box helicase domain of ATRX; Transcriptional regulator ATRX (also called alpha thalassemia/mental retardation syndrome X-linked and X-linked nuclear protein or XNP) is involved in transcriptional regulation and chromatin remodeling. Mutations in humans cause mental retardation, X-linked, syndromic, with hypotonic facies 1 (MRXSHF1) and alpha-thalassemia myelodysplasia syndrome (ATMDS). ATRX is part of the a DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350826 [Multi-domain] Cd Length: 246 Bit Score: 100.35 E-value: 3.05e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 717 GILADEMGLGKTIQTISLL-AYLACEK-ENWGPHLIVVPTSVLLNWEMEFKRFAPGFK--------VLTYYGSPQQRKEK 786
Cdd:cd18068 31 CILAHCMGLGKTLQVVTFLhTVLLCEKlENFSRVLVVCPLNTVLNWLNEFEKWQEGLKdeekievnELATYKRPQERSYK 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 787 RKGWNKPDAfhVCIVSYQL-----VVQDQHSFKRKRWQYM-----------VLDEAHNIKNFRSTRWQALLNFNTQRRLL 850
Cdd:cd18068 111 LQRWQEEGG--VMIIGYDMyrilaQERNVKSREKLKEIFNkalvdpgpdfvVCDEGHILKNEASAVSKAMNSIRTKRRIV 188
|
170 180
....*....|....*....|..
gi 6320541 851 LTGTPLQNNLAELWSLLYFLMP 872
Cdd:cd18068 189 LTGTPLQNNLIEYHCMVNFVKP 210
|
|
| DEXHc_RAD54A |
cd18067 |
DEXH-box helicase domain of RAD54A; DNA repair and recombination protein RAD54A, also known as ... |
696-872 |
2.84e-22 |
|
DEXH-box helicase domain of RAD54A; DNA repair and recombination protein RAD54A, also known as RAD54L or RAD54, plays a role in homologous recombination related repair of DNA double-strand breaks. RAD54A is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350825 [Multi-domain] Cd Length: 243 Bit Score: 97.54 E-value: 2.84e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 696 LRTYQKQGLNWL----ASLYNNHTNG-ILADEMGLGKTIQTISLLAYLACEKENWGPHL----IVVPTSVLLNWEMEF-K 765
Cdd:cd18067 1 LRPHQREGVKFLyrcvTGRRIRGSHGcIMADEMGLGKTLQCITLMWTLLRQSPQCKPEIdkaiVVSPSSLVKNWANELgK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 766 RFAPGFKVLTYYG-SPQQRKEKRKGWNKPDAFH----VCIVSYQLVVQDQHSFKRKRWQYMVLDEAHNIKNFRSTRWQAL 840
Cdd:cd18067 81 WLGGRLQPLAIDGgSKKEIDRKLVQWASQQGRRvstpVLIISYETFRLHVEVLQKGEVGLVICDEGHRLKNSDNQTYQAL 160
|
170 180 190
....*....|....*....|....*....|..
gi 6320541 841 LNFNTQRRLLLTGTPLQNNLAELWSLLYFLMP 872
Cdd:cd18067 161 DSLNTQRRVLLSGTPIQNDLSEYFSLVNFVNP 192
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
1276-1359 |
4.97e-21 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 88.42 E-value: 4.97e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 1276 DVLEQFLNYHGYLYMRLDGATKIEDRQILTERFNTDSRitVFILSSRSGGLGINLTGADTVIFYDSDWNPAMDKQCQDRC 1355
Cdd:smart00490 1 EELAELLKELGIKVARLHGGLSQEEREEILDKFNNGKI--KVLVATDVAERGLDLPGVDLVIIYDLPWSPASYIQRIGRA 78
|
....
gi 6320541 1356 HRIG 1359
Cdd:smart00490 79 GRAG 82
|
|
| DEXHc_ARIP4 |
cd18069 |
DEXH-box helicase domain of ARIP4; Androgen receptor-interacting protein 4 (ARIP4, also called ... |
718-906 |
2.56e-20 |
|
DEXH-box helicase domain of ARIP4; Androgen receptor-interacting protein 4 (ARIP4, also called RAD54 like 2 or RAD54L2 ) modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. ARIP4 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350827 [Multi-domain] Cd Length: 227 Bit Score: 91.42 E-value: 2.56e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 718 ILADEMGLGKTIQTISLLaYLACEKENWGPHLIVVPTSVLLNWEMEFKRFAPGFKVLtyygspqqrkekrkGWNKPDAFH 797
Cdd:cd18069 32 ILAHSMGLGKTLQVISFL-DVLLRHTGAKTVLAIVPVNTLQNWLSEFNKWLPPPEAL--------------PNVRPRPFK 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 798 VcivsyqLVVQDQHSFKRKRWQYM--------------------------VLDEAHNIKNFRSTRWQALLNFNTQRRLLL 851
Cdd:cd18069 97 V------FILNDEHKTTAARAKVIedwvkdggvllmgyemfrlrpgpdvvICDEGHRIKNCHASTSQALKNIRSRRRIVL 170
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 6320541 852 TGTPLQNNLAELWSLLYFLMPQTVidGKKVSgfadldaFQQWFGRPvdkiIETGQ 906
Cdd:cd18069 171 TGYPLQNNLIEYWCMVDFVRPDFL--GTRQE-------FSNMFERP----ILNGQ 212
|
|
| DEXQc_SHPRH |
cd18070 |
DEXQ-box helicase domain of SHPRH; E3 ubiquitin-protein ligase SHPRH is a ubiquitously ... |
696-872 |
5.50e-18 |
|
DEXQ-box helicase domain of SHPRH; E3 ubiquitin-protein ligase SHPRH is a ubiquitously expressed protein that contains motifs characteristic of several DNA repair proteins, transcription factors, and helicases. SHPRH is a functional homolog of S. cerevisiae RAD5 and is involved in DNA repair. SHPRH is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350828 [Multi-domain] Cd Length: 257 Bit Score: 85.47 E-value: 5.50e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 696 LRTYQKQGLNWLASLynnhtNGILADEMGLGKTIQTISLL------------AYLACEKENWGPH-------------LI 750
Cdd:cd18070 1 LLPYQRRAVNWMLVP-----GGILADEMGLGKTVEVLALIllhprpdndldaADDDSDEMVCCPDclvaetpvsskatLI 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 751 VVPTSVLLNWEMEFKRFAPG-FKVLTYYGSpqqrkEKRKGWNKPDAFHVCivSYQLVV------------------QDQH 811
Cdd:cd18070 76 VCPSAILAQWLDEINRHVPSsLKVLTYQGV-----KKDGALASPAPEILA--EYDIVVttydvlrtelhyaeanrsNRRR 148
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6320541 812 SFKRKRWQYM-----------VLDEAHNIKNFRSTRWQALLNFNTQRRLLLTGTPLQNNLAELWSLLYFLMP 872
Cdd:cd18070 149 RRQKRYEAPPsplvlvewwrvCLDEAQMVESSTSKAAEMARRLPRVNRWCVSGTPIQRGLDDLFGLLSFLGV 220
|
|
| SSL2 |
COG1061 |
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair]; |
627-855 |
3.65e-17 |
|
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
Pssm-ID: 440681 [Multi-domain] Cd Length: 566 Bit Score: 87.00 E-value: 3.65e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 627 NSSSVEGEELEKDQVDNSAATFERAGDFVHTQNENRDDIKDVEEDAETKVQEEQLSVVDVPVPSllRGNLRTYQKQGLN- 705
Cdd:COG1061 14 LRSSLLLLDLERLELSLLRNLVEARRLAIKEGTREDGRRLPEEDTERELAEAEALEAGDEASGT--SFELRPYQQEALEa 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 706 WLASLYNNHTNGILADEMGLGKTIqtisLLAYLACEKENWGPHLIVVPTSVLLN-WEMEFKRFAPGFKVltyygspqqrk 784
Cdd:COG1061 92 LLAALERGGGRGLVVAPTGTGKTV----LALALAAELLRGKRVLVLVPRRELLEqWAEELRRFLGDPLA----------- 156
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 6320541 785 ekrKGWNKPDAFHVCIVSYQLVVQDQHSFK-RKRWQYMVLDEAHNIknfRSTRWQALLN-FNTQRRLLLTGTP 855
Cdd:COG1061 157 ---GGGKKDSDAPITVATYQSLARRAHLDElGDRFGLVIIDEAHHA---GAPSYRRILEaFPAAYRLGLTATP 223
|
|
| DEXQc_bact_SNF2 |
cd18013 |
DEXQ-box helicase domain of bacterial SNF2 family proteins; Proteins belonging to the SNF2 ... |
696-870 |
6.97e-16 |
|
DEXQ-box helicase domain of bacterial SNF2 family proteins; Proteins belonging to the SNF2 family of DNA dependent ATPases are important members of the chromatin remodeling complexes that are implicated in epigenetic control of gene expression. The Snf2 family comprise a large group of ATP-hydrolyzing proteins that are ubiquitous in eukaryotes, but also present in eubacteria and archaea. The bacterial SNF2 present in this family are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350771 [Multi-domain] Cd Length: 218 Bit Score: 78.16 E-value: 6.97e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 696 LRTYQKQGLNWLASlynNHTNGILADeMGLGKTIQTISLLAYLAcEKENWGPHLIVVPTSVLLN-WEMEFKRFApGFKVL 774
Cdd:cd18013 1 PHPYQKVAINFIIE---HPYCGLFLD-MGLGKTVTTLTALSDLQ-LDDFTRRVLVIAPLRVARStWPDEVEKWN-HLRNL 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 775 TYY---GSPQQRkekRKGWNKPdaFHVCIVSYQLVVQDQHSFKrKRWQY--MVLDEAHNIKNFRSTRWQAL--LNFNTQR 847
Cdd:cd18013 75 TVSvavGTERQR---SKAANTP--ADLYVINRENLKWLVNKSG-DPWPFdmVVIDELSSFKSPRSKRFKALrkVRPVIKR 148
|
170 180
....*....|....*....|...
gi 6320541 848 RLLLTGTPLQNNLAELWSLLYFL 870
Cdd:cd18013 149 LIGLTGTPSPNGLMDLWAQIALL 171
|
|
| DEXHc_RE |
cd17926 |
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family ... |
696-855 |
4.81e-14 |
|
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family is composed of helicase restriction enzymes and similar proteins such as TFIIH basal transcription factor complex helicase XPB subunit. These proteins are part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350684 [Multi-domain] Cd Length: 146 Bit Score: 70.80 E-value: 4.81e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 696 LRTYQKQGL-NWLASLYNNHtnGILADEMGLGKTIQTISLLAYLACEKEnwgphLIVVPTSVLLN-WEMEFKRFAPGFKV 773
Cdd:cd17926 1 LRPYQEEALeAWLAHKNNRR--GILVLPTGSGKTLTALALIAYLKELRT-----LIVVPTDALLDqWKERFEDFLGDSSI 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 774 LTYYGSPQQRKEKRKgwnkpdafhVCIVSYQLVVQD--QHSFKRKRWQYMVLDEAHNI--KNFRstrwQALLNFNTQRRL 849
Cdd:cd17926 74 GLIGGGKKKDFDDAN---------VVVATYQSLSNLaeEEKDLFDQFGLLIVDEAHHLpaKTFS----EILKELNAKYRL 140
|
....*.
gi 6320541 850 LLTGTP 855
Cdd:cd17926 141 GLTATP 146
|
|
| HSA |
smart00573 |
domain in helicases and associated with SANT domains; |
340-393 |
5.99e-13 |
|
domain in helicases and associated with SANT domains;
Pssm-ID: 214727 [Multi-domain] Cd Length: 73 Bit Score: 65.50 E-value: 5.99e-13
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 6320541 340 SYFYKQQDLQIHTDHLINQGIHMSKLFRSSTKARIARAKKVSQMIEQHFKHVAG 393
Cdd:smart00573 1 QKLEEERRRKQHWDHLLEEMIWHAKDFKEEHKWKIAAAKKMAKAVMDYHQNKEK 54
|
|
| DISARM_DrmD_b |
NF038318 |
DISARM system SNF2-like helicase DrmD, short form; DrmD, a SNF2-like helicase, is a component ... |
718-1364 |
1.00e-11 |
|
DISARM system SNF2-like helicase DrmD, short form; DrmD, a SNF2-like helicase, is a component of class 1 DISARM (Defence Island System Associated with Restriction Modification), which contains a DNA adenine N6 methyltransferase. This HMM describes a distinct form that is somewhat shorter than the majority of DrmD proteins.
Pssm-ID: 468472 [Multi-domain] Cd Length: 868 Bit Score: 70.10 E-value: 1.00e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 718 ILADEMGLGKTIQTISLLAYLACEKENwgPHLIVVPTSVLLNWEMEF-KRFAPGFKVLTYYGSPQQRKEKRKGWNKPDAF 796
Cdd:NF038318 51 ILADEVGLGKTIEAGLVLKYVLESGAK--KILIILPANLRKQWEIELeEKFDLESLILDSLTVEKDAKKWNKRLTDNKKV 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 797 HVCIVSYQLVVQDQHSFKRKRWQYMVLDEAHNIKN-FRSTRWQALLNFNTQR--RLLLTGTPLQNNLAELWSLLYFLMPQ 873
Cdd:NF038318 129 RIVITSYDYASKLMKRFPKVKWDFIIIDEAHNLRNvHKGGKRAKNLYELTKGipKILLTATPLQNSLLDLYGLVSFIDPR 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 874 tVIDGKKVsgfadldaFQQWFGRpvdkiietGQNFgqdketkktvAKLHQVLRPYLLRRLKADVEKQM--PAKYEHIVYC 951
Cdd:NF038318 209 -IFGSEKV--------FSKRYIK--------DEDY----------SDLKRELSPVLYRTLRKDVADYMqfKKRKCITVDF 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 952 KLSKRQRFLYDdfmsraqtkatlasgnfmsivnclmqlrKVcnhpNLFEVRPILTSFVLEHcvasdykdveRTLLKLfkk 1031
Cdd:NF038318 262 ELSPDEIELYV----------------------------RV----NNFLKRDILYSIPTSN----------RTLIIL--- 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 1032 nnqVNRvdldflnlvftlndKDLTSyhaeeiSKLTCVKNFV---EEVNKLRETNKQLQEEFGEASFLNFqdanqyfkysn 1108
Cdd:NF038318 297 ---VIR--------------KLLAS------SSFALAETFEvlkKRLEKLKEGTRSANAQEGFDLFWSF----------- 342
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 1109 kqkLEGTVDmlnflkmvnklrcdrrpifgknlidllTKDRRVKYDKSSIIDNELIkplQTRVLDNRKIIDTfavltpsAV 1188
Cdd:NF038318 343 ---VEDEID---------------------------ESGFEEKQDELYTRQKEFI---QHEIDEVDAIIDV-------AK 382
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 1189 SLdmrklalglnddssvgeNTRLKVmqncfevsnplHQLQTKLTIAFPdkslLQYDCGKLQKLAI----------LLQQL 1258
Cdd:NF038318 383 RI-----------------KTNAKV-----------TALKTALEIAFE----YQREEGIAQKVVVfteskrtqkyIAEEL 430
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 1259 KDNGHRA---LIFT-----QMTKVLDVLEQFLNYHGYLYMRldgatKIEDRQILTERFNTDSRItvfILSSRSGGLGINL 1330
Cdd:NF038318 431 RKSGYEGediLLFNgdfddAMTKEIYRAWQVKNYGKANYGR-----SVEYKHAIVDYFKNNAKI---LIVTDAGSEGLNL 502
|
650 660 670
....*....|....*....|....*....|....
gi 6320541 1331 TGADTVIFYDSDWNPAMDKQCQDRCHRIGQTRDV 1364
Cdd:NF038318 503 QFCNTVINYDLPWNPQKIEQRIGRCHRYGQKNDV 536
|
|
| SF2-N |
cd00046 |
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ... |
714-854 |
9.93e-10 |
|
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.
Pssm-ID: 350668 [Multi-domain] Cd Length: 146 Bit Score: 58.57 E-value: 9.93e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 714 HTNGILADEMGLGKTIQTISLLAYLACEKEnwGPHLIVVPTSVLLN-WEMEFKRFAPGFKVLTYYGSPQQRKEKRKGWNk 792
Cdd:cd00046 1 GENVLITAPTGSGKTLAALLAALLLLLKKG--KKVLVLVPTKALALqTAERLRELFGPGIRVAVLVGGSSAEEREKNKL- 77
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 793 PDAfHVCIVSYQLV---VQDQHSFKRKRWQYMVLDEAHNI-KNFRSTRWQALLNFNTQ----RRLLLTGT 854
Cdd:cd00046 78 GDA-DIIIATPDMLlnlLLREDRLFLKDLKLIIVDEAHALlIDSRGALILDLAVRKAGlknaQVILLSAT 146
|
|
| HSA |
pfam07529 |
HSA domain; This domain is predicted to bind DNA and is often found associated with helicases. ... |
351-393 |
1.75e-09 |
|
HSA domain; This domain is predicted to bind DNA and is often found associated with helicases. This region does not form a compact domain in the known structures.
Pssm-ID: 462194 [Multi-domain] Cd Length: 67 Bit Score: 55.27 E-value: 1.75e-09
10 20 30 40
....*....|....*....|....*....|....*....|...
gi 6320541 351 HTDHLINQGIHMSKLFRSSTKARIARAKKVSQMIEQHFKHVAG 393
Cdd:pfam07529 11 HHDYLLEEILWHSKDFKQERRWKRARAKKLARAVAQYHKNIEK 53
|
|
| SF2_C |
cd18785 |
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ... |
1312-1361 |
1.14e-04 |
|
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350172 [Multi-domain] Cd Length: 77 Bit Score: 41.92 E-value: 1.14e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|
gi 6320541 1312 SRITVFILSSRSGGLGINLTGADTVIFYDSDWNPAMDKQCQDRCHRIGQT 1361
Cdd:cd18785 20 ASSLEILVATNVLGEGIDVPSLDTVIFFDPPSSAASYIQRVGRAGRGGKD 69
|
|
| PTZ00110 |
PTZ00110 |
helicase; Provisional |
1247-1361 |
1.76e-03 |
|
helicase; Provisional
Pssm-ID: 240273 [Multi-domain] Cd Length: 545 Bit Score: 42.84 E-value: 1.76e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 1247 KLQKLAILLQQLKDNGHRALIFTQMTKVLDVLEQFLNYHGYLYMRLDGATKIEDRQ-ILTERFNTDSRITVFI-LSSRsg 1324
Cdd:PTZ00110 362 KRGKLKMLLQRIMRDGDKILIFVETKKGADFLTKELRLDGWPALCIHGDKKQEERTwVLNEFKTGKSPIMIATdVASR-- 439
|
90 100 110
....*....|....*....|....*....|....*..
gi 6320541 1325 glGINLTGADTVIFYDsdwnpaMDKQCQDRCHRIGQT 1361
Cdd:PTZ00110 440 --GLDVKDVKYVINFD------FPNQIEDYVHRIGRT 468
|
|
| DEAD |
pfam00270 |
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ... |
724-855 |
4.73e-03 |
|
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.
Pssm-ID: 425570 [Multi-domain] Cd Length: 165 Bit Score: 39.53 E-value: 4.73e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320541 724 GLGKTIqtISLLAYLACEKENW-GPH-LIVVPTSVL-LNWEMEFKRFA--PGFKVLTYYGSPQQRKEKRKgWNKPdafHV 798
Cdd:pfam00270 24 GSGKTL--AFLLPALEALDKLDnGPQaLVLAPTRELaEQIYEELKKLGkgLGLKVASLLGGDSRKEQLEK-LKGP---DI 97
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 6320541 799 CIVSYQLVvqDQHSFKRKRWQ---YMVLDEAHNI--KNFRSTrWQALLN-FNTQRR-LLLTGTP 855
Cdd:pfam00270 98 LVGTPGRL--LDLLQERKLLKnlkLLVLDEAHRLldMGFGPD-LEEILRrLPKKRQiLLLSATL 158
|
|
| |
