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Conserved domains on  [gi|6320952|ref|NP_011031|]
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Nup157p [Saccharomyces cerevisiae S288C]

Protein Classification

nuclear pore complex Nup155/Nup170 family protein( domain architecture ID 11474919)

nuclear pore complex Nup155/Nup170 family protein is required for both nuclear envelope (NE) membrane fusion and nuclear pore complexes (NPCs) assembly

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NUP170 COG5308
Nuclear pore complex subunit [Intracellular trafficking and secretion];
73-1391 0e+00

Nuclear pore complex subunit [Intracellular trafficking and secretion];


:

Pssm-ID: 227624 [Multi-domain]  Cd Length: 1263  Bit Score: 1837.28  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320952    73 LRDVTTHVKISGLTSSEPLQLASEFVQDLSFRDRNTPILDNPDYYSKGLDYNFSDEVGglgaFTPFQRQQVTNIPDEVLS 152
Cdd:COG5308    1 MRQEGPHVGVSGMGYYELLLLALHWIGMLLKRDTKTPSLDEAKYYEEGLDYIFSIETG----FTPFYAQQVMNIPDRILS 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320952   153 QVSNTEIKSDMGIFLELNYCWITSDNKLILWNINNSSEYHCIDEIEHTILKVKLVKPSPNTFVSSVENLLIVATLFDIYI 232
Cdd:COG5308   77 QISRTEYKTDMGIFPELNRCWITNDNKLILWNYNNSNEYQEIDDFSHTILKVKLVRPKANTFVSRISHLLFVATEKEVMI 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320952   233 LTISFNDRTHELNIFNTGLKVNVTGFNVSNIISYErTGQIFFTGATDgVNVWELQYNCSENLFNSKSNKICLTKSNLANL 312
Cdd:COG5308  157 LGVSKDTKTGELSLFNTGLVVSVQGINVRCIVSEE-DGRIFFGGEND-PNVYELVYKSSDSWFNSKCSKICLTKSILSSL 234

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320952   313 LPTKLIPSIPGgkliqkvlegdagteeETISQLEVDQSRGVLHTLSTKSIVRSYLITSNGLVGPVLIDAAHIRRGMNALG 392
Cdd:COG5308  235 LPSFFSFGIPG----------------ETIKQLAVDQSRGLLYVLRKKSAVRAYSITKNGLVGPVFISFASIDRNAAILN 298

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320952   393 VkNSPLLSNRAFKIAKIVSISMCENNDLFLAVITTTGVRLYFKGSISRRSIGSLKLDSVKFPPTSISSSLEQNK-SFIIG 471
Cdd:COG5308  299 A-TSPLLEPRMYKIVKIVSIPAYENNQLFLVAITSTGCRLYFDGSRGRVSIVALKLDSVKFPPPSTLMQLEQNKgSRDFY 377

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320952   472 HHpLNTHDTGPLSTQKASSTYINTTCASTIISPGIYFTCVRKRANSGELSKGITNKALLENKEEHKLYVSAPDYGILKNY 551
Cdd:COG5308  378 EN-LFLDRLVMLKRQPNSSDMTETTEMSTIISPGIYFSAVNKRYDSSNTNKGSTVTAISLNVDQHKLWVSIPDYGILKSS 456

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320952   552 gKYVENTALLDTTDEIKEIVPLTRSFNYTSTPQGyanVFASQYSAEPLKVAVLTSNALEIYCYRTPDEVFESLIENPLPF 631
Cdd:COG5308  457 -KYVENVVFLDDIELIQNIDPRTELFNQTNTPQA---TFALLYGNEKLFVAVLTSVEKEIYSYRTPDEIFSGLIGNPLPF 532

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320952   632 IHSYGLSEACSTALYLACKFNKSEHIKSSALAFFSAGIPGVVEIKPKSSRESGSVPPISQNLFDKSGECDGIVLSPRFYG 711
Cdd:COG5308  533 YKSYGEAEACSTALLYYCKLNKSEDVGSLALLFLKLGIPDVVDIKPKYYRYSGSVPILSQSRFNKPSSLDFVRLSPRFYG 612

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320952   712 SALLITRLFSQIWEERVFVFKRaskTEKMDAFGISItRPQVEYYLSSISVLADFFNIHRPSFVSFVPPKGSNAITASDAE 791
Cdd:COG5308  613 LALLITRLERNIWLERVFSKMQ---NKMINIRGASI-KIKIEYYLSGIDFLDEFLENNKSSIEGLNSPLISNDEIAVQAE 688

                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320952   792 SIAMNALILLINSIKDALSLINVFYEDidafksLLNTLMGAGGVYDSKTREYFFDLKFHDLFTPNaKTKQLIKEILIEVV 871
Cdd:COG5308  689 SIANNALLLEYQSIKEGLSLLNVLYED------GVSDFHEIVSSTSIDIQKSCSNLTFSELFTPN-KTKKLIKEILKSLV 761

                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320952   872 NANIASGTSADYIVNVLKERFGSFCHSADILCYRAGEHLEAAQKFEmIDSKISRNHLDTAIDLYERCAENIELCELRRVV 951
Cdd:COG5308  762 NRNIQSGGSIEYLIKTLSERCGSFCSAEDVLYFRALEHLNKAKSRE-VDLESLNNHLKNAVQLNESLVAKYNEEGLRYAV 840

                        890       900       910       920       930       940       950       960
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320952   952 DIMVKLNYQPKTVGFLLRFADKIDKGNQAQEYVSRGCNTADPRKVFYDKRINVYTLIFEIVKSVDDYTSIEQSpsianis 1031
Cdd:COG5308  841 TTMISLNYYPKAVNFLLEYAVEIDKGNQACAYVLNGLAENDPRKDFYDKRIKVYSLIFEILISVDKENSLRNS------- 913

                        970       980       990      1000      1010      1020      1030      1040
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320952  1032 ifspasSLKKRVYSVIMNSNNRFFHYCFYDWLVANKRQDYLLRLDSQFVLPYLKERAEKSLEISNLLWFYLFKEEHFLEA 1111
Cdd:COG5308  914 ------ELKCCVYPSAMGSNDRLFHYCFYDWLVFKGRTDRLIKIDSPFILPYLKEKAMSSLKISNLLWKYYVKREDFVEA 987

                       1050      1060      1070      1080      1090      1100      1110      1120
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320952  1112 ADVLYALASSDFDLKLSERIECLARANGLCDSSTSFDQKPALVQLSENIHELFDIASIQDDLLNLVRNETRIDEDYRKQL 1191
Cdd:COG5308  988 AQVLYELATSNFDVSLEERIELLRRANGFCSSHVPNSQKHVNVQLFNEVKERLEVASIQDDILRLVRVDPRIDNNKREEL 1067

                       1130      1140      1150      1160      1170      1180      1190      1200
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320952  1192 TLKLNGRVLPLSDLFNDCADPLDYYEIKLRIFKVSQFKDEKVIQGEWNRLLDSMKNAPSPDVGSVGQESFLSSISNTLIR 1271
Cdd:COG5308 1068 SKQLDGEILSLSELFNDYADPLKYPEIALKIFKISDYRDKAVIRELWEELMSSHENAIISPVGSSDFESFVSFLSNLLIK 1147

                       1210      1220      1230      1240      1250      1260      1270      1280
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320952  1272 IGKttrdTDVVFPVHFLMNKILESFIDKSSAADGSVCSMFLLAGVSHLKLYYILSRIIENSEGNVELAKKEMVWLIKDWY 1351
Cdd:COG5308 1148 ISK----SENVFPIMDLNDIVGDIFCDKEMAAGGSVGSAFLSAGVSHLKVYYILEELIEQSKDRLFFLIKEMTWLIKEWY 1223

                       1290      1300      1310      1320
                 ....*....|....*....|....*....|....*....|
gi 6320952  1352 QSDSDLRGSIAPEQIKKLEKYDPNTDPVQDYVKDRHHGLK 1391
Cdd:COG5308 1224 HSDMSFRARILLEDIKKLKNYNEFYDPVEKYCKRKYGILD 1263
 
Name Accession Description Interval E-value
NUP170 COG5308
Nuclear pore complex subunit [Intracellular trafficking and secretion];
73-1391 0e+00

Nuclear pore complex subunit [Intracellular trafficking and secretion];


Pssm-ID: 227624 [Multi-domain]  Cd Length: 1263  Bit Score: 1837.28  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320952    73 LRDVTTHVKISGLTSSEPLQLASEFVQDLSFRDRNTPILDNPDYYSKGLDYNFSDEVGglgaFTPFQRQQVTNIPDEVLS 152
Cdd:COG5308    1 MRQEGPHVGVSGMGYYELLLLALHWIGMLLKRDTKTPSLDEAKYYEEGLDYIFSIETG----FTPFYAQQVMNIPDRILS 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320952   153 QVSNTEIKSDMGIFLELNYCWITSDNKLILWNINNSSEYHCIDEIEHTILKVKLVKPSPNTFVSSVENLLIVATLFDIYI 232
Cdd:COG5308   77 QISRTEYKTDMGIFPELNRCWITNDNKLILWNYNNSNEYQEIDDFSHTILKVKLVRPKANTFVSRISHLLFVATEKEVMI 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320952   233 LTISFNDRTHELNIFNTGLKVNVTGFNVSNIISYErTGQIFFTGATDgVNVWELQYNCSENLFNSKSNKICLTKSNLANL 312
Cdd:COG5308  157 LGVSKDTKTGELSLFNTGLVVSVQGINVRCIVSEE-DGRIFFGGEND-PNVYELVYKSSDSWFNSKCSKICLTKSILSSL 234

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320952   313 LPTKLIPSIPGgkliqkvlegdagteeETISQLEVDQSRGVLHTLSTKSIVRSYLITSNGLVGPVLIDAAHIRRGMNALG 392
Cdd:COG5308  235 LPSFFSFGIPG----------------ETIKQLAVDQSRGLLYVLRKKSAVRAYSITKNGLVGPVFISFASIDRNAAILN 298

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320952   393 VkNSPLLSNRAFKIAKIVSISMCENNDLFLAVITTTGVRLYFKGSISRRSIGSLKLDSVKFPPTSISSSLEQNK-SFIIG 471
Cdd:COG5308  299 A-TSPLLEPRMYKIVKIVSIPAYENNQLFLVAITSTGCRLYFDGSRGRVSIVALKLDSVKFPPPSTLMQLEQNKgSRDFY 377

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320952   472 HHpLNTHDTGPLSTQKASSTYINTTCASTIISPGIYFTCVRKRANSGELSKGITNKALLENKEEHKLYVSAPDYGILKNY 551
Cdd:COG5308  378 EN-LFLDRLVMLKRQPNSSDMTETTEMSTIISPGIYFSAVNKRYDSSNTNKGSTVTAISLNVDQHKLWVSIPDYGILKSS 456

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320952   552 gKYVENTALLDTTDEIKEIVPLTRSFNYTSTPQGyanVFASQYSAEPLKVAVLTSNALEIYCYRTPDEVFESLIENPLPF 631
Cdd:COG5308  457 -KYVENVVFLDDIELIQNIDPRTELFNQTNTPQA---TFALLYGNEKLFVAVLTSVEKEIYSYRTPDEIFSGLIGNPLPF 532

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320952   632 IHSYGLSEACSTALYLACKFNKSEHIKSSALAFFSAGIPGVVEIKPKSSRESGSVPPISQNLFDKSGECDGIVLSPRFYG 711
Cdd:COG5308  533 YKSYGEAEACSTALLYYCKLNKSEDVGSLALLFLKLGIPDVVDIKPKYYRYSGSVPILSQSRFNKPSSLDFVRLSPRFYG 612

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320952   712 SALLITRLFSQIWEERVFVFKRaskTEKMDAFGISItRPQVEYYLSSISVLADFFNIHRPSFVSFVPPKGSNAITASDAE 791
Cdd:COG5308  613 LALLITRLERNIWLERVFSKMQ---NKMINIRGASI-KIKIEYYLSGIDFLDEFLENNKSSIEGLNSPLISNDEIAVQAE 688

                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320952   792 SIAMNALILLINSIKDALSLINVFYEDidafksLLNTLMGAGGVYDSKTREYFFDLKFHDLFTPNaKTKQLIKEILIEVV 871
Cdd:COG5308  689 SIANNALLLEYQSIKEGLSLLNVLYED------GVSDFHEIVSSTSIDIQKSCSNLTFSELFTPN-KTKKLIKEILKSLV 761

                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320952   872 NANIASGTSADYIVNVLKERFGSFCHSADILCYRAGEHLEAAQKFEmIDSKISRNHLDTAIDLYERCAENIELCELRRVV 951
Cdd:COG5308  762 NRNIQSGGSIEYLIKTLSERCGSFCSAEDVLYFRALEHLNKAKSRE-VDLESLNNHLKNAVQLNESLVAKYNEEGLRYAV 840

                        890       900       910       920       930       940       950       960
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320952   952 DIMVKLNYQPKTVGFLLRFADKIDKGNQAQEYVSRGCNTADPRKVFYDKRINVYTLIFEIVKSVDDYTSIEQSpsianis 1031
Cdd:COG5308  841 TTMISLNYYPKAVNFLLEYAVEIDKGNQACAYVLNGLAENDPRKDFYDKRIKVYSLIFEILISVDKENSLRNS------- 913

                        970       980       990      1000      1010      1020      1030      1040
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320952  1032 ifspasSLKKRVYSVIMNSNNRFFHYCFYDWLVANKRQDYLLRLDSQFVLPYLKERAEKSLEISNLLWFYLFKEEHFLEA 1111
Cdd:COG5308  914 ------ELKCCVYPSAMGSNDRLFHYCFYDWLVFKGRTDRLIKIDSPFILPYLKEKAMSSLKISNLLWKYYVKREDFVEA 987

                       1050      1060      1070      1080      1090      1100      1110      1120
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320952  1112 ADVLYALASSDFDLKLSERIECLARANGLCDSSTSFDQKPALVQLSENIHELFDIASIQDDLLNLVRNETRIDEDYRKQL 1191
Cdd:COG5308  988 AQVLYELATSNFDVSLEERIELLRRANGFCSSHVPNSQKHVNVQLFNEVKERLEVASIQDDILRLVRVDPRIDNNKREEL 1067

                       1130      1140      1150      1160      1170      1180      1190      1200
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320952  1192 TLKLNGRVLPLSDLFNDCADPLDYYEIKLRIFKVSQFKDEKVIQGEWNRLLDSMKNAPSPDVGSVGQESFLSSISNTLIR 1271
Cdd:COG5308 1068 SKQLDGEILSLSELFNDYADPLKYPEIALKIFKISDYRDKAVIRELWEELMSSHENAIISPVGSSDFESFVSFLSNLLIK 1147

                       1210      1220      1230      1240      1250      1260      1270      1280
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320952  1272 IGKttrdTDVVFPVHFLMNKILESFIDKSSAADGSVCSMFLLAGVSHLKLYYILSRIIENSEGNVELAKKEMVWLIKDWY 1351
Cdd:COG5308 1148 ISK----SENVFPIMDLNDIVGDIFCDKEMAAGGSVGSAFLSAGVSHLKVYYILEELIEQSKDRLFFLIKEMTWLIKEWY 1223

                       1290      1300      1310      1320
                 ....*....|....*....|....*....|....*....|
gi 6320952  1352 QSDSDLRGSIAPEQIKKLEKYDPNTDPVQDYVKDRHHGLK 1391
Cdd:COG5308 1224 HSDMSFRARILLEDIKKLKNYNEFYDPVEKYCKRKYGILD 1263
Nucleoporin_N pfam08801
Nup133 N terminal like; Nup133 is a nucleoporin that is crucial for nuclear pore complex (NPC) ...
 134-611 6.54e-95

Nup133 N terminal like; Nup133 is a nucleoporin that is crucial for nuclear pore complex (NPC) biogenesis. The N terminal forms a seven-bladed beta propeller structure. This family now contains other sized nucleoporins, including Nup155, Nup8, Nuo132, Nup15 and Nup170.


Pssm-ID: 400932  Cd Length: 426  Bit Score: 312.40  E-value: 6.54e-95
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320952     134 AFTPFQRQ-QVTNIPDEVLSQVSNTEIKSDMGIFLELNYCWITSDNKLILWNINNS-----SEYHCIDEIEHTILKVK-L 206
Cdd:pfam08801    1 TENDFYKVsKLPPLPDEVLEELSFAEAPTKGGVFPEIGRAWITVDNKLFIWNYNSTassplTDTIPLDEESHTILPVGpL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320952     207 VKPSPNTFVSSVENLLIVATLFDIYILTISFND----RTHELNIFNTGLKVNVTGFNVSNIISYERTGQIFFTGATDgvN 282
Cdd:pfam08801   81 VKPKPGTFVPEPGLVLVVATTGDIVYWESISSAgallSLNELQGLETDLSVLSDGEYVTDLVNSEPAGRIFLAGSTG--R 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320952     283 VWELQYNCSENLFNSKSNKICLTKSNLANLlptKLIPSIPGGkliqkvlegdaGTEEETISQLEVDQSRG--VLHTLSTK 360
Cdd:pfam08801  159 LYELTYRDSSGKPSLKCRKIRSPSGGFSSL---SIIPSVFGG-----------GSEREEIVSLRVDPSRGerLLYTLTSK 224

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320952     361 SIVRSYLITSNGlvGPVLIDAAHIRRGMN-ALGVKNSPLLSNRAFKIAKIVSISMCENNDLFLAVITTTGVRLYFKG-SI 438
Cdd:pfam08801  225 GVIQVWDLSSSG--GSDLKSDADIRQIILeAISLISTAPLASKSLKILDISPIDSDESSLLHLVAITSNGVRLYYLLsTI 302

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320952     439 SRRSIGSLKLDSVKFPPtsisssleqnksfiighhPLNTHDTGPLSTQKASSTYINTtcastiISPGIYFTCVRKRAnsg 518
Cdd:pfam08801  303 LLDSPSVLSLSSVRFPP------------------RLNTYSSKLLEGKKKPRLLIPS------YSPGTFLFVVFDSS--- 355

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320952     519 elskgitnkallenkeehKLYVSAPDYGIlkNYGKYVENTALLDTTDEIKEIVPLTRSFNYTSTPQGYANVFASQYSaeP 598
Cdd:pfam08801  356 ------------------VVLVSLSDYGF--PHGKLVEDTSFYPLDGPWEDIISLRPVLDATILGSGYENVSASQYS--P 413

                          490
                   ....*....|...
gi 6320952     599 LKVAVLTSNALEI 611
Cdd:pfam08801  414 AKFVLLTNFGVVI 426
 
Name Accession Description Interval E-value
NUP170 COG5308
Nuclear pore complex subunit [Intracellular trafficking and secretion];
73-1391 0e+00

Nuclear pore complex subunit [Intracellular trafficking and secretion];


Pssm-ID: 227624 [Multi-domain]  Cd Length: 1263  Bit Score: 1837.28  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320952    73 LRDVTTHVKISGLTSSEPLQLASEFVQDLSFRDRNTPILDNPDYYSKGLDYNFSDEVGglgaFTPFQRQQVTNIPDEVLS 152
Cdd:COG5308    1 MRQEGPHVGVSGMGYYELLLLALHWIGMLLKRDTKTPSLDEAKYYEEGLDYIFSIETG----FTPFYAQQVMNIPDRILS 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320952   153 QVSNTEIKSDMGIFLELNYCWITSDNKLILWNINNSSEYHCIDEIEHTILKVKLVKPSPNTFVSSVENLLIVATLFDIYI 232
Cdd:COG5308   77 QISRTEYKTDMGIFPELNRCWITNDNKLILWNYNNSNEYQEIDDFSHTILKVKLVRPKANTFVSRISHLLFVATEKEVMI 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320952   233 LTISFNDRTHELNIFNTGLKVNVTGFNVSNIISYErTGQIFFTGATDgVNVWELQYNCSENLFNSKSNKICLTKSNLANL 312
Cdd:COG5308  157 LGVSKDTKTGELSLFNTGLVVSVQGINVRCIVSEE-DGRIFFGGEND-PNVYELVYKSSDSWFNSKCSKICLTKSILSSL 234

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320952   313 LPTKLIPSIPGgkliqkvlegdagteeETISQLEVDQSRGVLHTLSTKSIVRSYLITSNGLVGPVLIDAAHIRRGMNALG 392
Cdd:COG5308  235 LPSFFSFGIPG----------------ETIKQLAVDQSRGLLYVLRKKSAVRAYSITKNGLVGPVFISFASIDRNAAILN 298

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320952   393 VkNSPLLSNRAFKIAKIVSISMCENNDLFLAVITTTGVRLYFKGSISRRSIGSLKLDSVKFPPTSISSSLEQNK-SFIIG 471
Cdd:COG5308  299 A-TSPLLEPRMYKIVKIVSIPAYENNQLFLVAITSTGCRLYFDGSRGRVSIVALKLDSVKFPPPSTLMQLEQNKgSRDFY 377

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320952   472 HHpLNTHDTGPLSTQKASSTYINTTCASTIISPGIYFTCVRKRANSGELSKGITNKALLENKEEHKLYVSAPDYGILKNY 551
Cdd:COG5308  378 EN-LFLDRLVMLKRQPNSSDMTETTEMSTIISPGIYFSAVNKRYDSSNTNKGSTVTAISLNVDQHKLWVSIPDYGILKSS 456

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320952   552 gKYVENTALLDTTDEIKEIVPLTRSFNYTSTPQGyanVFASQYSAEPLKVAVLTSNALEIYCYRTPDEVFESLIENPLPF 631
Cdd:COG5308  457 -KYVENVVFLDDIELIQNIDPRTELFNQTNTPQA---TFALLYGNEKLFVAVLTSVEKEIYSYRTPDEIFSGLIGNPLPF 532

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320952   632 IHSYGLSEACSTALYLACKFNKSEHIKSSALAFFSAGIPGVVEIKPKSSRESGSVPPISQNLFDKSGECDGIVLSPRFYG 711
Cdd:COG5308  533 YKSYGEAEACSTALLYYCKLNKSEDVGSLALLFLKLGIPDVVDIKPKYYRYSGSVPILSQSRFNKPSSLDFVRLSPRFYG 612

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320952   712 SALLITRLFSQIWEERVFVFKRaskTEKMDAFGISItRPQVEYYLSSISVLADFFNIHRPSFVSFVPPKGSNAITASDAE 791
Cdd:COG5308  613 LALLITRLERNIWLERVFSKMQ---NKMINIRGASI-KIKIEYYLSGIDFLDEFLENNKSSIEGLNSPLISNDEIAVQAE 688

                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320952   792 SIAMNALILLINSIKDALSLINVFYEDidafksLLNTLMGAGGVYDSKTREYFFDLKFHDLFTPNaKTKQLIKEILIEVV 871
Cdd:COG5308  689 SIANNALLLEYQSIKEGLSLLNVLYED------GVSDFHEIVSSTSIDIQKSCSNLTFSELFTPN-KTKKLIKEILKSLV 761

                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320952   872 NANIASGTSADYIVNVLKERFGSFCHSADILCYRAGEHLEAAQKFEmIDSKISRNHLDTAIDLYERCAENIELCELRRVV 951
Cdd:COG5308  762 NRNIQSGGSIEYLIKTLSERCGSFCSAEDVLYFRALEHLNKAKSRE-VDLESLNNHLKNAVQLNESLVAKYNEEGLRYAV 840

                        890       900       910       920       930       940       950       960
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320952   952 DIMVKLNYQPKTVGFLLRFADKIDKGNQAQEYVSRGCNTADPRKVFYDKRINVYTLIFEIVKSVDDYTSIEQSpsianis 1031
Cdd:COG5308  841 TTMISLNYYPKAVNFLLEYAVEIDKGNQACAYVLNGLAENDPRKDFYDKRIKVYSLIFEILISVDKENSLRNS------- 913

                        970       980       990      1000      1010      1020      1030      1040
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320952  1032 ifspasSLKKRVYSVIMNSNNRFFHYCFYDWLVANKRQDYLLRLDSQFVLPYLKERAEKSLEISNLLWFYLFKEEHFLEA 1111
Cdd:COG5308  914 ------ELKCCVYPSAMGSNDRLFHYCFYDWLVFKGRTDRLIKIDSPFILPYLKEKAMSSLKISNLLWKYYVKREDFVEA 987

                       1050      1060      1070      1080      1090      1100      1110      1120
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320952  1112 ADVLYALASSDFDLKLSERIECLARANGLCDSSTSFDQKPALVQLSENIHELFDIASIQDDLLNLVRNETRIDEDYRKQL 1191
Cdd:COG5308  988 AQVLYELATSNFDVSLEERIELLRRANGFCSSHVPNSQKHVNVQLFNEVKERLEVASIQDDILRLVRVDPRIDNNKREEL 1067

                       1130      1140      1150      1160      1170      1180      1190      1200
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320952  1192 TLKLNGRVLPLSDLFNDCADPLDYYEIKLRIFKVSQFKDEKVIQGEWNRLLDSMKNAPSPDVGSVGQESFLSSISNTLIR 1271
Cdd:COG5308 1068 SKQLDGEILSLSELFNDYADPLKYPEIALKIFKISDYRDKAVIRELWEELMSSHENAIISPVGSSDFESFVSFLSNLLIK 1147

                       1210      1220      1230      1240      1250      1260      1270      1280
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320952  1272 IGKttrdTDVVFPVHFLMNKILESFIDKSSAADGSVCSMFLLAGVSHLKLYYILSRIIENSEGNVELAKKEMVWLIKDWY 1351
Cdd:COG5308 1148 ISK----SENVFPIMDLNDIVGDIFCDKEMAAGGSVGSAFLSAGVSHLKVYYILEELIEQSKDRLFFLIKEMTWLIKEWY 1223

                       1290      1300      1310      1320
                 ....*....|....*....|....*....|....*....|
gi 6320952  1352 QSDSDLRGSIAPEQIKKLEKYDPNTDPVQDYVKDRHHGLK 1391
Cdd:COG5308 1224 HSDMSFRARILLEDIKKLKNYNEFYDPVEKYCKRKYGILD 1263
Nucleoporin_N pfam08801
Nup133 N terminal like; Nup133 is a nucleoporin that is crucial for nuclear pore complex (NPC) ...
 134-611 6.54e-95

Nup133 N terminal like; Nup133 is a nucleoporin that is crucial for nuclear pore complex (NPC) biogenesis. The N terminal forms a seven-bladed beta propeller structure. This family now contains other sized nucleoporins, including Nup155, Nup8, Nuo132, Nup15 and Nup170.


Pssm-ID: 400932  Cd Length: 426  Bit Score: 312.40  E-value: 6.54e-95
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320952     134 AFTPFQRQ-QVTNIPDEVLSQVSNTEIKSDMGIFLELNYCWITSDNKLILWNINNS-----SEYHCIDEIEHTILKVK-L 206
Cdd:pfam08801    1 TENDFYKVsKLPPLPDEVLEELSFAEAPTKGGVFPEIGRAWITVDNKLFIWNYNSTassplTDTIPLDEESHTILPVGpL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320952     207 VKPSPNTFVSSVENLLIVATLFDIYILTISFND----RTHELNIFNTGLKVNVTGFNVSNIISYERTGQIFFTGATDgvN 282
Cdd:pfam08801   81 VKPKPGTFVPEPGLVLVVATTGDIVYWESISSAgallSLNELQGLETDLSVLSDGEYVTDLVNSEPAGRIFLAGSTG--R 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320952     283 VWELQYNCSENLFNSKSNKICLTKSNLANLlptKLIPSIPGGkliqkvlegdaGTEEETISQLEVDQSRG--VLHTLSTK 360
Cdd:pfam08801  159 LYELTYRDSSGKPSLKCRKIRSPSGGFSSL---SIIPSVFGG-----------GSEREEIVSLRVDPSRGerLLYTLTSK 224

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320952     361 SIVRSYLITSNGlvGPVLIDAAHIRRGMN-ALGVKNSPLLSNRAFKIAKIVSISMCENNDLFLAVITTTGVRLYFKG-SI 438
Cdd:pfam08801  225 GVIQVWDLSSSG--GSDLKSDADIRQIILeAISLISTAPLASKSLKILDISPIDSDESSLLHLVAITSNGVRLYYLLsTI 302

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320952     439 SRRSIGSLKLDSVKFPPtsisssleqnksfiighhPLNTHDTGPLSTQKASSTYINTtcastiISPGIYFTCVRKRAnsg 518
Cdd:pfam08801  303 LLDSPSVLSLSSVRFPP------------------RLNTYSSKLLEGKKKPRLLIPS------YSPGTFLFVVFDSS--- 355

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320952     519 elskgitnkallenkeehKLYVSAPDYGIlkNYGKYVENTALLDTTDEIKEIVPLTRSFNYTSTPQGYANVFASQYSaeP 598
Cdd:pfam08801  356 ------------------VVLVSLSDYGF--PHGKLVEDTSFYPLDGPWEDIISLRPVLDATILGSGYENVSASQYS--P 413

                          490
                   ....*....|...
gi 6320952     599 LKVAVLTSNALEI 611
Cdd:pfam08801  414 AKFVLLTNFGVVI 426
Nucleoporin_C pfam03177
Non-repetitive/WGA-negative nucleoporin C-terminal; This is the C-termainl half of a family of ...
 745-1286 3.49e-49

Non-repetitive/WGA-negative nucleoporin C-terminal; This is the C-termainl half of a family of nucleoporin proteins. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells, and mediate bidirectional nucleocytoplasmic transport, especially of mRNA and proteins. Two nucleoporin classes are known: one is characterized by the FG repeat pfam03093; the other is represented by this family, and lacks any repeats. RNA undergoing nuclear export first encounters the basket of the nuclear pore and many nucleoporins are accessible on the basket side of the pore.


Pssm-ID: 427181  Cd Length: 559  Bit Score: 184.82  E-value: 3.49e-49
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320952     745 ISITRPQVEYYLSSISVLADFFNIHRPSFvsfvppkgsNAIT----ASDAESIA----------------------MNAL 798
Cdd:pfam03177    1 LASLEQNLELRLSALDDLAEFLKSNGVSI---------DRDTrwelLWQAEKIAaatalwkkheaflaerpekrtlLNSI 71

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320952     799 ILLINSIKDALSLINVFYEDIDAFkslLNTLMGAGGVYDSKTREY-----FFDLKFHDLFTP---------NAK-----T 859
Cdd:pfam03177   72 IKLINSMKEALSFLNVLYEANEIS---LAALEEAFGFRDENAAFYgigdeLLEDGIEGLPEPwtstsyiysNLKrqldlT 148

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320952     860 KQLIKEILievvnANIASGTSADYIVNVLKERFGSFCHSADILCYRAGEHLeaaQKFEMIDSKisrnHLDTAIDLYERCA 939
Cdd:pfam03177  149 LLWFKDLF-----APNTRGGSIEPDATLLQEICGSFCSLTDVLGFSAIERL---RWAKEQLDP----KLQNAGKLLEEAY 216

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320952     940 ENIELCELRRVVDI---------MVKLNYQPKTVGFLLRFADKIDKGNQAQEYVSRgcNTADPRKVFYDKRINVYtliFE 1010
Cdd:pfam03177  217 DSDRKWQIFKLASIgkleeaielAEKLRDYPALVELLLEIANQLEDKAPDSGDDER--KEYYNRAEELDKRISLY---FE 291

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320952    1011 ivksvddytsieqspsianisifspasslkkrvysvimnSNNRFFHYCFYDWLVANKRQDYLL--RLDSQFVLPYLKERA 1088
Cdd:pfam03177  292 ---------------------------------------RFGELFAYAFYDWLISQGQVERLLdfKDNTPFITPFLREKP 332

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320952    1089 EksleISNLLWFY-LFKEEHFLEAADVLYALASSDFDLKLSERIE-CLARANGLCDSSTSFDQKPALVQLSENIHELFDI 1166
Cdd:pfam03177  333 E----YAKLSWINdVTKEKDYDHAAEILYSLALSQEQDVWSKRIElSLAKLALLAELEESDTPDVGLETDLERIDDLLEV 408

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320952    1167 ASIQDDLLNLVRNETR--IDEDYRKQLTLK-----------------------LNGRVLPLSDLFND----------CAD 1211
Cdd:pfam03177  409 INIQDDLYSLILPSIQgaIDEKAEVQLAMEqfgnvlddrpalrqllkdglkklLKHKILDASDLIDLltlmdlrpgeDED 488

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320952    1212 PLDYYEIKLRIFKVSQFKDEK------------VIQGEWNRLLDSMKnapspdvgsvgqesflssisNTLIRIGKTTRDT 1279
Cdd:pfam03177  489 PLGYFYLALRVLKLSDLRNEDedalerliwrrcMIRDDWEELNDTLK--------------------KEDAEVEAQLRST 548


                   ....*..
gi 6320952    1280 DVVFPVH 1286
Cdd:pfam03177  549 ALYFTLS 555
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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