NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|398364891|ref|NP_012048|]
View 

Stb5p [Saccharomyces cerevisiae S288C]

Protein Classification

Zn(II)2Cys6 transcription factor( domain architecture ID 10445721)

Zn(II)2Cys6 transcription factor domain-containing proteins form a subclass of zinc finger proteins found exclusively in fungi

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
fungal_TF_MHR cd12148
fungal transcription factor regulatory middle homology region; This domain is present in the ...
293-699 5.58e-56

fungal transcription factor regulatory middle homology region; This domain is present in the large family of fungal zinc cluster transcription factors that contain an N-terminal GAL4-like C6 zinc binuclear cluster DNA-binding domain. Examples of members of this large fungal group are the following Saccharomyces cerevisiae transcription factors, GAL4, STB5, DAL81, CAT8, RDR1, HAL9, PUT3, PPR1, ASG1, RSF2, PIP2, as well as the C-terminal domain of the Cep3, a subunit of the yeast centromere-binding factor 3. It has been suggested that this region plays a regulatory role.


:

Pssm-ID: 213391  Cd Length: 410  Bit Score: 197.28  E-value: 5.58e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364891 293 IDRSLLDRFIAAYFKHNHRLFPMIDKIAFLNDaatitdFERLYDNKNYPD-SFVFKVYMIMAIGCTTLQRAGMVSQDEEC 371
Cdd:cd12148    1 PPREVADRLLDLYFENVHPLFPILHRPTFLRD------LESLYSDPSSLSpASLALLLAVLALAALSLPDSELRGESRRS 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364891 372 LSEHLAFLAMKKFRSVIILQ-DIETVRCLLLLGIYSFFEPKGSSSWTISGIIMRLTIGLGLNRELTAkkLKSMSALEAEA 450
Cdd:cd12148   75 LAERYYEAARQLLDLALFLPpSLETLQALLLLALYLLGTGDPSSAWLLLGLAIRLAQSLGLHRDPSS--LPGLSPFEREL 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364891 451 RYRVFWSAYCFERLVCTSLGRISGIDDEDITVPLPRALYVDERD-------------DLEMTKLMISLRKMGGRIYKQVH 517
Cdd:cd12148  153 RRRLWWSLYILDRLLSLSLGRPPSISDEDIDVPLPSNEDDELSPssspppppseeptSLSFFIALIRLARILGRILRLLY 232
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364891 518 SVSAgrqkLTIEQKQEIISGLRKELDEIYsreserrklkkSQMDQVERENNSTTNVISFHSSEIWLAMRYSQLQILLYRP 597
Cdd:cd12148  233 SPRA----SSPEDSLETILELDAELEEWR-----------ASLPPELRLDSSSLESPSLLPQRLLLHLLYHLLLILLHRP 297
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364891 598 ---SALMPKPPIDSLSTLGEFCLQAWKHTYTLYKK-----RLLPLNWITLFRTLTICNTILYCLCQ--WSIDLIESKIEI 667
Cdd:cd12148  298 fllRSLSSLSPSSSSAESRRACLEAAREILELLRLllsssLLLLLWWFLLYYLFSAALVLLLALLLrpSSSELEEARSLL 377
                        410       420       430
                 ....*....|....*....|....*....|...
gi 398364891 668 QQCVEILRHFGERW-IFAMRCADVFQNISNTIL 699
Cdd:cd12148  378 ERALELLERLSERWpRLARRALRLLERLLARAR 410
Zn_clus pfam00172
Fungal Zn(2)-Cys(6) binuclear cluster domain;
20-58 2.34e-12

Fungal Zn(2)-Cys(6) binuclear cluster domain;


:

Pssm-ID: 395120 [Multi-domain]  Cd Length: 39  Bit Score: 61.54  E-value: 2.34e-12
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 398364891   20 YSCARCRKLKKKCGKQIPTCANCDKNGAHCSYPGRAPRR 58
Cdd:pfam00172   1 TACDNCRKRKVKCDGKKPACSRCIKNGLECTYSRKSKKS 39
 
Name Accession Description Interval E-value
fungal_TF_MHR cd12148
fungal transcription factor regulatory middle homology region; This domain is present in the ...
293-699 5.58e-56

fungal transcription factor regulatory middle homology region; This domain is present in the large family of fungal zinc cluster transcription factors that contain an N-terminal GAL4-like C6 zinc binuclear cluster DNA-binding domain. Examples of members of this large fungal group are the following Saccharomyces cerevisiae transcription factors, GAL4, STB5, DAL81, CAT8, RDR1, HAL9, PUT3, PPR1, ASG1, RSF2, PIP2, as well as the C-terminal domain of the Cep3, a subunit of the yeast centromere-binding factor 3. It has been suggested that this region plays a regulatory role.


Pssm-ID: 213391  Cd Length: 410  Bit Score: 197.28  E-value: 5.58e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364891 293 IDRSLLDRFIAAYFKHNHRLFPMIDKIAFLNDaatitdFERLYDNKNYPD-SFVFKVYMIMAIGCTTLQRAGMVSQDEEC 371
Cdd:cd12148    1 PPREVADRLLDLYFENVHPLFPILHRPTFLRD------LESLYSDPSSLSpASLALLLAVLALAALSLPDSELRGESRRS 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364891 372 LSEHLAFLAMKKFRSVIILQ-DIETVRCLLLLGIYSFFEPKGSSSWTISGIIMRLTIGLGLNRELTAkkLKSMSALEAEA 450
Cdd:cd12148   75 LAERYYEAARQLLDLALFLPpSLETLQALLLLALYLLGTGDPSSAWLLLGLAIRLAQSLGLHRDPSS--LPGLSPFEREL 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364891 451 RYRVFWSAYCFERLVCTSLGRISGIDDEDITVPLPRALYVDERD-------------DLEMTKLMISLRKMGGRIYKQVH 517
Cdd:cd12148  153 RRRLWWSLYILDRLLSLSLGRPPSISDEDIDVPLPSNEDDELSPssspppppseeptSLSFFIALIRLARILGRILRLLY 232
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364891 518 SVSAgrqkLTIEQKQEIISGLRKELDEIYsreserrklkkSQMDQVERENNSTTNVISFHSSEIWLAMRYSQLQILLYRP 597
Cdd:cd12148  233 SPRA----SSPEDSLETILELDAELEEWR-----------ASLPPELRLDSSSLESPSLLPQRLLLHLLYHLLLILLHRP 297
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364891 598 ---SALMPKPPIDSLSTLGEFCLQAWKHTYTLYKK-----RLLPLNWITLFRTLTICNTILYCLCQ--WSIDLIESKIEI 667
Cdd:cd12148  298 fllRSLSSLSPSSSSAESRRACLEAAREILELLRLllsssLLLLLWWFLLYYLFSAALVLLLALLLrpSSSELEEARSLL 377
                        410       420       430
                 ....*....|....*....|....*....|...
gi 398364891 668 QQCVEILRHFGERW-IFAMRCADVFQNISNTIL 699
Cdd:cd12148  378 ERALELLERLSERWpRLARRALRLLERLLARAR 410
Fungal_trans pfam04082
Fungal specific transcription factor domain; This domain is found in a number of fungal ...
302-544 5.22e-29

Fungal specific transcription factor domain; This domain is found in a number of fungal transcription factors including transcriptional activator xlnR, yeast regulatory protein GAL4, and nicotinate catabolism cluster-specific transcription factor HxnR.


Pssm-ID: 397964  Cd Length: 262  Bit Score: 116.44  E-value: 5.22e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364891  302 IAAYFKHNHRLFPMIDKIAFLNDaatitDFERLYDNKNYPDSFVfkVYMIMAIGCTTLQragMVSQDEECLSEHLAFLAM 381
Cdd:pfam04082   1 LDLFFKNFHPQFPILHRPSFLRD-----YFELFSSPSNYASPLL--LLAILALGALFSE---SPTARSSSSLTDEAADGI 70
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364891  382 KKFRSVIILQ---------DIETVRCLLLLGIYSFFEPKGSSSWTISGIIMRLTIGLGLNRELTAK-KLKSMSALEAEAR 451
Cdd:pfam04082  71 HFFLRALILIhedfsspssSLWILQALLLLELYELGTGDRKLHWRYHGLAIRLARSLGLHRDPSYVsPSWKLWIEEAELR 150
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364891  452 YRVFWSAYCFERLVCTSLGRISGIDDEDITVPLP----------------RALYVDERDDLEMTKLMISLRKMGGRIYKQ 515
Cdd:pfam04082 151 RRLFWACFYLDRLISLILGRPPLLSDSDIDLPLPcddddlwesdsadevtLPLISLESKSIKPPLFLIKLSKILSKILGS 230
                         250       260
                  ....*....|....*....|....*....
gi 398364891  516 VHSVSAGRQKLTIEQKQEIISGLRKELDE 544
Cdd:pfam04082 231 LLSIRSTLDQRDLQLKLSWVRELERALDN 259
Fungal_trans smart00906
Fungal specific transcription factor domain; This domain is found in a number of fungal ...
392-489 1.85e-22

Fungal specific transcription factor domain; This domain is found in a number of fungal transcription factors including transcriptional activator xlnR, yeast regulatory protein GAL4, and other transcription proteins regulating a variety of cellular and metabolic processes.


Pssm-ID: 214903 [Multi-domain]  Cd Length: 93  Bit Score: 92.13  E-value: 1.85e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364891   392 DIETVRCLLLLgIYSFFEPKGSSSWTISGIIMRLTIGLGLNRELTAKKLksmsaLEAEARYRVFWSAYCFERLVCTSLGR 471
Cdd:smart00906   1 SLETVQALLLA-LLSLYLGGRDAAWMLLGLAIRLAQALGLHRDPSNSDL-----EERERRRRRFWWLYILDRLLSLSLGR 74
                           90
                   ....*....|....*...
gi 398364891   472 ISGIDDEDITVPLPRALY 489
Cdd:smart00906  75 PPLIDDDDIDVPLPSDLD 92
Zn_clus pfam00172
Fungal Zn(2)-Cys(6) binuclear cluster domain;
20-58 2.34e-12

Fungal Zn(2)-Cys(6) binuclear cluster domain;


Pssm-ID: 395120 [Multi-domain]  Cd Length: 39  Bit Score: 61.54  E-value: 2.34e-12
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 398364891   20 YSCARCRKLKKKCGKQIPTCANCDKNGAHCSYPGRAPRR 58
Cdd:pfam00172   1 TACDNCRKRKVKCDGKKPACSRCIKNGLECTYSRKSKKS 39
GAL4 smart00066
GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster DNA-binding domain; Gal4 is a positive ...
21-58 3.88e-11

GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster DNA-binding domain; Gal4 is a positive regulator for the gene expression of the galactose- induced genes of S. cerevisiae. Is present only in fungi.


Pssm-ID: 214501 [Multi-domain]  Cd Length: 43  Bit Score: 58.53  E-value: 3.88e-11
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 398364891    21 SCARCRKLKKKCGKQIPTCANCDKNGAHCSYPGRAPRR 58
Cdd:smart00066   6 ACDRCRKRKIKCDGKKPPCSNCIKLGLECTYSDSKKRK 43
GAL4 cd00067
GAL4-like Zn2Cys6 binuclear cluster DNA-binding domain; found in transcription regulators like ...
21-52 9.96e-10

GAL4-like Zn2Cys6 binuclear cluster DNA-binding domain; found in transcription regulators like GAL4. Domain consists of two helices organized around a Zn(2)Cys(6 )motif; Binds to sequences containing 2 DNA half sites comprised of 3-5 C/G combinations


Pssm-ID: 238023 [Multi-domain]  Cd Length: 36  Bit Score: 54.21  E-value: 9.96e-10
                         10        20        30
                 ....*....|....*....|....*....|..
gi 398364891  21 SCARCRKLKKKCGKQIPTCANCDKNGAHCSYP 52
Cdd:cd00067    5 ACDRCRRRKIKCDGEKPPCSNCIKLGLECTYS 36
 
Name Accession Description Interval E-value
fungal_TF_MHR cd12148
fungal transcription factor regulatory middle homology region; This domain is present in the ...
293-699 5.58e-56

fungal transcription factor regulatory middle homology region; This domain is present in the large family of fungal zinc cluster transcription factors that contain an N-terminal GAL4-like C6 zinc binuclear cluster DNA-binding domain. Examples of members of this large fungal group are the following Saccharomyces cerevisiae transcription factors, GAL4, STB5, DAL81, CAT8, RDR1, HAL9, PUT3, PPR1, ASG1, RSF2, PIP2, as well as the C-terminal domain of the Cep3, a subunit of the yeast centromere-binding factor 3. It has been suggested that this region plays a regulatory role.


Pssm-ID: 213391  Cd Length: 410  Bit Score: 197.28  E-value: 5.58e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364891 293 IDRSLLDRFIAAYFKHNHRLFPMIDKIAFLNDaatitdFERLYDNKNYPD-SFVFKVYMIMAIGCTTLQRAGMVSQDEEC 371
Cdd:cd12148    1 PPREVADRLLDLYFENVHPLFPILHRPTFLRD------LESLYSDPSSLSpASLALLLAVLALAALSLPDSELRGESRRS 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364891 372 LSEHLAFLAMKKFRSVIILQ-DIETVRCLLLLGIYSFFEPKGSSSWTISGIIMRLTIGLGLNRELTAkkLKSMSALEAEA 450
Cdd:cd12148   75 LAERYYEAARQLLDLALFLPpSLETLQALLLLALYLLGTGDPSSAWLLLGLAIRLAQSLGLHRDPSS--LPGLSPFEREL 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364891 451 RYRVFWSAYCFERLVCTSLGRISGIDDEDITVPLPRALYVDERD-------------DLEMTKLMISLRKMGGRIYKQVH 517
Cdd:cd12148  153 RRRLWWSLYILDRLLSLSLGRPPSISDEDIDVPLPSNEDDELSPssspppppseeptSLSFFIALIRLARILGRILRLLY 232
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364891 518 SVSAgrqkLTIEQKQEIISGLRKELDEIYsreserrklkkSQMDQVERENNSTTNVISFHSSEIWLAMRYSQLQILLYRP 597
Cdd:cd12148  233 SPRA----SSPEDSLETILELDAELEEWR-----------ASLPPELRLDSSSLESPSLLPQRLLLHLLYHLLLILLHRP 297
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364891 598 ---SALMPKPPIDSLSTLGEFCLQAWKHTYTLYKK-----RLLPLNWITLFRTLTICNTILYCLCQ--WSIDLIESKIEI 667
Cdd:cd12148  298 fllRSLSSLSPSSSSAESRRACLEAAREILELLRLllsssLLLLLWWFLLYYLFSAALVLLLALLLrpSSSELEEARSLL 377
                        410       420       430
                 ....*....|....*....|....*....|...
gi 398364891 668 QQCVEILRHFGERW-IFAMRCADVFQNISNTIL 699
Cdd:cd12148  378 ERALELLERLSERWpRLARRALRLLERLLARAR 410
Fungal_trans pfam04082
Fungal specific transcription factor domain; This domain is found in a number of fungal ...
302-544 5.22e-29

Fungal specific transcription factor domain; This domain is found in a number of fungal transcription factors including transcriptional activator xlnR, yeast regulatory protein GAL4, and nicotinate catabolism cluster-specific transcription factor HxnR.


Pssm-ID: 397964  Cd Length: 262  Bit Score: 116.44  E-value: 5.22e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364891  302 IAAYFKHNHRLFPMIDKIAFLNDaatitDFERLYDNKNYPDSFVfkVYMIMAIGCTTLQragMVSQDEECLSEHLAFLAM 381
Cdd:pfam04082   1 LDLFFKNFHPQFPILHRPSFLRD-----YFELFSSPSNYASPLL--LLAILALGALFSE---SPTARSSSSLTDEAADGI 70
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364891  382 KKFRSVIILQ---------DIETVRCLLLLGIYSFFEPKGSSSWTISGIIMRLTIGLGLNRELTAK-KLKSMSALEAEAR 451
Cdd:pfam04082  71 HFFLRALILIhedfsspssSLWILQALLLLELYELGTGDRKLHWRYHGLAIRLARSLGLHRDPSYVsPSWKLWIEEAELR 150
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364891  452 YRVFWSAYCFERLVCTSLGRISGIDDEDITVPLP----------------RALYVDERDDLEMTKLMISLRKMGGRIYKQ 515
Cdd:pfam04082 151 RRLFWACFYLDRLISLILGRPPLLSDSDIDLPLPcddddlwesdsadevtLPLISLESKSIKPPLFLIKLSKILSKILGS 230
                         250       260
                  ....*....|....*....|....*....
gi 398364891  516 VHSVSAGRQKLTIEQKQEIISGLRKELDE 544
Cdd:pfam04082 231 LLSIRSTLDQRDLQLKLSWVRELERALDN 259
Fungal_trans smart00906
Fungal specific transcription factor domain; This domain is found in a number of fungal ...
392-489 1.85e-22

Fungal specific transcription factor domain; This domain is found in a number of fungal transcription factors including transcriptional activator xlnR, yeast regulatory protein GAL4, and other transcription proteins regulating a variety of cellular and metabolic processes.


Pssm-ID: 214903 [Multi-domain]  Cd Length: 93  Bit Score: 92.13  E-value: 1.85e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364891   392 DIETVRCLLLLgIYSFFEPKGSSSWTISGIIMRLTIGLGLNRELTAKKLksmsaLEAEARYRVFWSAYCFERLVCTSLGR 471
Cdd:smart00906   1 SLETVQALLLA-LLSLYLGGRDAAWMLLGLAIRLAQALGLHRDPSNSDL-----EERERRRRRFWWLYILDRLLSLSLGR 74
                           90
                   ....*....|....*...
gi 398364891   472 ISGIDDEDITVPLPRALY 489
Cdd:smart00906  75 PPLIDDDDIDVPLPSDLD 92
Zn_clus pfam00172
Fungal Zn(2)-Cys(6) binuclear cluster domain;
20-58 2.34e-12

Fungal Zn(2)-Cys(6) binuclear cluster domain;


Pssm-ID: 395120 [Multi-domain]  Cd Length: 39  Bit Score: 61.54  E-value: 2.34e-12
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 398364891   20 YSCARCRKLKKKCGKQIPTCANCDKNGAHCSYPGRAPRR 58
Cdd:pfam00172   1 TACDNCRKRKVKCDGKKPACSRCIKNGLECTYSRKSKKS 39
GAL4 smart00066
GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster DNA-binding domain; Gal4 is a positive ...
21-58 3.88e-11

GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster DNA-binding domain; Gal4 is a positive regulator for the gene expression of the galactose- induced genes of S. cerevisiae. Is present only in fungi.


Pssm-ID: 214501 [Multi-domain]  Cd Length: 43  Bit Score: 58.53  E-value: 3.88e-11
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 398364891    21 SCARCRKLKKKCGKQIPTCANCDKNGAHCSYPGRAPRR 58
Cdd:smart00066   6 ACDRCRKRKIKCDGKKPPCSNCIKLGLECTYSDSKKRK 43
GAL4 cd00067
GAL4-like Zn2Cys6 binuclear cluster DNA-binding domain; found in transcription regulators like ...
21-52 9.96e-10

GAL4-like Zn2Cys6 binuclear cluster DNA-binding domain; found in transcription regulators like GAL4. Domain consists of two helices organized around a Zn(2)Cys(6 )motif; Binds to sequences containing 2 DNA half sites comprised of 3-5 C/G combinations


Pssm-ID: 238023 [Multi-domain]  Cd Length: 36  Bit Score: 54.21  E-value: 9.96e-10
                         10        20        30
                 ....*....|....*....|....*....|..
gi 398364891  21 SCARCRKLKKKCGKQIPTCANCDKNGAHCSYP 52
Cdd:cd00067    5 ACDRCRRRKIKCDGEKPPCSNCIKLGLECTYS 36
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH