|
Name |
Accession |
Description |
Interval |
E-value |
| LeuB |
COG0473 |
Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid ... |
23-371 |
3.46e-149 |
|
Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid transport and metabolism]; Isocitrate/isopropylmalate dehydrogenase is part of the Pathway/BioSystem: TCA cycle
Pssm-ID: 440241 Cd Length: 346 Bit Score: 424.81 E-value: 3.46e-149
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322097 23 SLTIGLIPGDGIGKEVIPAGKQVLENLNSKHGLSFNFIDLYAGFQTFQETGKALPDETVKVLKEqCQGALFGAVQSPttK 102
Cdd:COG0473 1 TYKIAVLPGDGIGPEVVAAALKVLEAAAERFGLDFEFEEADIGGAAYDKTGTPLPDETLEALRK-ADAILLGAVGGP--K 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322097 103 V---EGYSSPIVALRREMGLFANVRPVKSVEG-------EKGKPIDMVIVRENTEDLYIKIEKtYIDKATGTRVADATKR 172
Cdd:COG0473 78 WddgVRPESGLLALRKELDLYANLRPAKLYPGlpsplkpEIVEGIDLVIVRENTEGLYFGIGG-RIGTGTGEEVAIDTRV 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322097 173 ISEIATRRIATIALDIALKRlqtRGQatLTVTHKSNVLSQSDGLFREICKEVYEsnkdKYGQIKYNEQIVDSMVYRLFRE 252
Cdd:COG0473 157 YTRKGIERIARYAFELARKR---RKK--VTSVDKANVLKLTSGLWREVVREVAK----EYPDVELDHMYVDAAAMQLVRN 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322097 253 PQCFDVIVAPNLYGDILSDGAAALVGSLGVVPSANVGPEIV-IGEPCHGSAPDIAGKGIANPIATIRSTALMLEFLGHNE 331
Cdd:COG0473 228 PEQFDVIVTENLFGDILSDLAAGLTGSLGLAPSANIGDEGKaLFEPVHGSAPDIAGKGIANPIATILSAAMMLRHLGEEE 307
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 6322097 332 AAQDIYKAVDANLREGsIKTPDLGGKASTQQVVDDVLSRL 371
Cdd:COG0473 308 AADAIEAAVEKVLAEG-VRTPDLGGKAGTSEMGDAIIAAL 346
|
|
| Iso_dh |
pfam00180 |
Isocitrate/isopropylmalate dehydrogenase; |
25-367 |
5.90e-146 |
|
Isocitrate/isopropylmalate dehydrogenase;
Pssm-ID: 425507 Cd Length: 346 Bit Score: 416.70 E-value: 5.90e-146
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322097 25 TIGLIPGDGIGKEVIPAGKQVLENLNSKHGLSFNFIDLYAGFQTFQETGKALPDETVKVLKEQcQGALFGAVQSPTT--- 101
Cdd:pfam00180 1 KIAVLPGDGIGPEVMAAALKVLKAALEKAPLEFEFEERDVGGAAIDETGEPLPDETLEACKKA-DAVLLGAVGGPKWdpa 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322097 102 KVEGYSSpIVALRREMGLFANVRPVKSVEGEKGKP--------IDMVIVRENTEDLYIKIEKTYIDKatGTRVADATKRI 173
Cdd:pfam00180 80 GVRPENG-LLALRKELGLFANLRPAKVFPPLGDASplknevegVDIVIVRELTGGIYFGIEKGIKGS--GNEVAVDTKLY 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322097 174 SEIATRRIATIALDIALKRlqtrGQATLTVTHKSNVLSQSDgLFREICKEVYesnKDKYGQIKYNEQIVDSMVYRLFREP 253
Cdd:pfam00180 157 SRDEIERIARVAFELARKR----GRKKVTSVDKANVLKSSD-LWRKIVTEVA---KAEYPDVELEHQLVDNAAMQLVKNP 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322097 254 QCFDVIVAPNLYGDILSDGAAALVGSLGVVPSANVGP-EIVIGEPCHGSAPDIAGKGIANPIATIRSTALMLEF-LGHNE 331
Cdd:pfam00180 229 SQFDVIVTPNLFGDILSDEASMLTGSLGLLPSASLGAnGFGIFEPVHGSAPDIAGKGIANPIATILSAAMMLRYsLGLED 308
|
330 340 350
....*....|....*....|....*....|....*....
gi 6322097 332 AAQDIYKAVDANLREGsIKTPDLGGKA---STQQVVDDV 367
Cdd:pfam00180 309 AADKIEAAVLKVLESG-IRTGDLAGSAtyvSTSEFGEAV 346
|
|
| AksF2_Meth |
NF040626 |
homoisocitrate dehydrogenase; |
25-371 |
2.85e-118 |
|
homoisocitrate dehydrogenase;
Pssm-ID: 468598 Cd Length: 332 Bit Score: 345.95 E-value: 2.85e-118
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322097 25 TIGLIPGDGIGKEVIPAGKQVLENLNskhgLSFNFIDLYAGFQTFQETGKALPDETVKVLKeQCQGALFGAVqsptTKVE 104
Cdd:NF040626 3 KITVIPGDGIGKEVMEAALYVLDALD----LNFDFIEAEAGRECFKKNGTTIPEETIKIAK-KSDATLFGAV----TSTP 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322097 105 GYSSPIVALRREMGLFANVRPVKSVEGEKG--KPIDMVIVRENTEDLYIKIEKTYIDKAtgtrvADATKRISEIATRRIA 182
Cdd:NF040626 74 GQKSPIITLRKELDLYANLRPIKSYEGINClfKDLDFLIVRENTEGLYSGLEEEYTEEK-----AIAERVITRKASERIC 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322097 183 TIALDIALKRlqtrGQATLTVTHKSNVLSQSDGLFREICKEVYEsnkdKYGQIKYNEQIVDSMVYRLFREPQCFDVIVAP 262
Cdd:NF040626 149 KFAFEYAIKL----GRKKVTAVHKANVLKKTDGIFKDTFYKVAK----DYPQIETEDYYVDATAMYLITKPQDFDVIVTT 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322097 263 NLYGDILSDGAAALVGSLGVVPSANVGPEIVIGEPCHGSAPDIAGKGIANPIATIRSTALMLEFLGHNEAAQDIYKAVDA 342
Cdd:NF040626 221 NLFGDILSDEAAGLVGGLGLAPSANIGDKNGLFEPVHGSAPDIAGKNIANPIAMILSASMMLDYLGETYEANKLENALEK 300
|
330 340
....*....|....*....|....*....
gi 6322097 343 NLREGSIKTPDLGGKASTQQVVDDVLSRL 371
Cdd:NF040626 301 VLREGKVVTPDLGGNAKTMEMANEIKKKI 329
|
|
| PRK14025 |
PRK14025 |
multifunctional 3-isopropylmalate dehydrogenase/D-malate dehydrogenase; Provisional |
26-371 |
1.01e-114 |
|
multifunctional 3-isopropylmalate dehydrogenase/D-malate dehydrogenase; Provisional
Pssm-ID: 184462 Cd Length: 330 Bit Score: 336.72 E-value: 1.01e-114
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322097 26 IGLIPGDGIGKEVIPAGKQVLENLnskhGLSFNFIDLYAGFQTFQETGKALPDETVKVLKEqCQGALFGAVQspttkvEG 105
Cdd:PRK14025 4 ICVIEGDGIGKEVVPAALHVLEAT----GLPFEFVYAEAGDEVFEKTGKALPEETIEAAKE-ADAVLFGAAG------ET 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322097 106 YSSPIVALRREMGLFANVRPVKSVEGEK--GKPIDMVIVRENTEDLYIKIEKtyidkATGTRVADATKRISEIATRRIAT 183
Cdd:PRK14025 73 AADVIVKLRRILDTYANVRPVKSYKGVKclYPDIDYVIVRENTEGLYKGIEA-----EIADGVTVATRVITRKASERIFR 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322097 184 IALDIALKRLQTRGQATLTVTHKSNVLSQSDGLFREICKEVYEsnkdKYGQIKYNEQIVDSMVYRLFREPQCFDVIVAPN 263
Cdd:PRK14025 148 FAFEMAKRRKKMGKEGKVTCAHKANVLKKTDGLFKKTFYEVAK----EYPDIKAEDYYVDAMNMYIITRPQTFDVVVTSN 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322097 264 LYGDILSDGAAALVGSLGVVPSANVGPEIVIGEPCHGSAPDIAGKGIANPIATIRSTALMLEFLGHNEAAQDIYKAVDAN 343
Cdd:PRK14025 224 LFGDILSDGAAGLVGGLGLAPSANIGDKYGLFEPVHGSAPDIAGKGIANPTATILTAVLMLRHLGENEEADKVEKALEEV 303
|
330 340
....*....|....*....|....*...
gi 6322097 344 LREGsIKTPDLGGKASTQQVVDDVLSRL 371
Cdd:PRK14025 304 LALG-LTTPDLGGNLSTMEMAEEVAKRV 330
|
|
| LEU3_arch |
TIGR02088 |
isopropylmalate/isohomocitrate dehydrogenases; This model represents a group of archaeal ... |
26-368 |
1.65e-111 |
|
isopropylmalate/isohomocitrate dehydrogenases; This model represents a group of archaeal decarboxylating dehydrogenases which include the leucine biosynthesis enzyme 3-isopropylmalate dehydrogenase (LeuB, LEU3) and the methanogenic cofactor CoB biosynthesis enzyme isohomocitrate dehydrogenase (AksF). Both of these have been characterized in Methanococcus janaschii. Non-methanogenic archaea have only one hit to this model and presumably this is LeuB, although phylogenetic trees cannot establish which gene is which in the methanogens. The AksF gene is capable of acting on isohomocitrate, iso(homo)2-citrate and iso(homo)3-citrate in the successive elongation cycles of coenzyme B (7-mercaptoheptanoyl-threonine phosphate). This family is closely related to both the LeuB genes found in TIGR00169 and the mitochondrial eukaryotic isocitrate dehydratases found in TIGR00175. All of these are included within the broader subfamily model, pfam00180.
Pssm-ID: 273962 Cd Length: 322 Bit Score: 328.26 E-value: 1.65e-111
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322097 26 IGLIPGDGIGKEVIPAGKQVLEnlnsKHGLSFNFIDLYAGFQTFQETGKALPDETVKVLKEqCQGALFGAVQspTTKVEG 105
Cdd:TIGR02088 1 VAVIPGDGIGPEVIEAAIRILN----KLGLEIEFIEFEAGDEALKKYGSALPEDTLEEIRK-ADAILFGAVT--TPANPG 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322097 106 YSSPIVALRREMGLFANVRPVKSVEGEKGKP---IDMVIVRENTEDLYIKIEKTYIDKATGTRVadatkrISEIATRRIA 182
Cdd:TIGR02088 74 YKSVIVTLRKELDLYANVRPAKSLPGIPDLYpngKDIVIVRENTEGLYAGFEFGFSDRAIAIRV------ITREGSERIA 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322097 183 TIALDIALKRlqtrgQATLTVTHKSNVLSQSDGLFREICKEVYESnkdkYGqIKYNEQIVDSMVYRLFREPQCFDVIVAP 262
Cdd:TIGR02088 148 RFAFNLAKER-----NRKVTCVHKANVLKGTDGLFREVCREIAKR----YG-VEYRDMYVDSAAMNLVKDPWRFDVIVTT 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322097 263 NLYGDILSDGAAALVGSLGVVPSANVGPEIVIGEPCHGSAPDIAGKGIANPIATIRSTALMLEFLGHNEAAQDIYKAVDA 342
Cdd:TIGR02088 218 NMFGDILSDLASALAGSLGLAPSANIGDRKALFEPVHGSAPDIAGKGIANPTAAILSVAMMLDYLGELEKGKLVWEAVEY 297
|
330 340
....*....|....*....|....*.
gi 6322097 343 NLREGSiKTPDLGGKASTQQVVDDVL 368
Cdd:TIGR02088 298 YIIEGK-KTPDLGGTAKTKEVGDEIA 322
|
|
| AksF_Meth |
NF040619 |
homoisocitrate dehydrogenase; |
26-367 |
8.54e-100 |
|
homoisocitrate dehydrogenase;
Pssm-ID: 468591 Cd Length: 332 Bit Score: 298.98 E-value: 8.54e-100
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322097 26 IGLIPGDGIGKEVIPAGKQVLENLNSkhglsFNFIDLYAGFQTFQETGKALPDETVKVLKEqCQGALFGAVQSPT---TK 102
Cdd:NF040619 4 ICVIEGDGIGKEVIPETVRVLKELGD-----FEFIKGEAGLECFKKYGDAIPEETIEKAKE-CDAILFGAVTTPKpteLK 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322097 103 VEGYSSPIVALRREMGLFANVRPVKSV-EGEKGKPIDMVIVRENTEDLYIKIEKtYIDKatgTRVADATKRISEIATRRI 181
Cdd:NF040619 78 NKNYKSPILTLRKELDLYANVRPINNFgDGQDVKNIDFVIIRENTEGLYVGREY-YDEE---NEIAIAERIISKKGSERI 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322097 182 ATIALDIALKRLQTRgqatLTVTHKSNVLSQSDGLFREICKEVYESNKDKygQIKYNEQIVDSMVYRLFREPQCFDVIVA 261
Cdd:NF040619 154 IKFAFEYAKKNNRKK----VSCIHKANVLRVTDGLFLEIFNEIKKKYKNF--NIEADDYLVDATAMYLIKNPEMFDVIVT 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322097 262 PNLYGDILSDGAAALVGSLGVVPSANVGPEIVIGEPCHGSAPDIAGKGIANPIATIRSTALMLEFLGHNEAAQDIYKAVD 341
Cdd:NF040619 228 TNLFGDILSDEASGLIGGLGLAPSANIGDKKGLFEPVHGSAPDIAGKGIANPIATILSAAMMLDYLGMKEKGDLIREAVK 307
|
330 340
....*....|....*....|....*.
gi 6322097 342 ANLREGSIkTPDLGGKASTQQVVDDV 367
Cdd:NF040619 308 KCLENGKV-TPDLGGNLKTKEVTDKI 332
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| LeuB |
COG0473 |
Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid ... |
23-371 |
3.46e-149 |
|
Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid transport and metabolism]; Isocitrate/isopropylmalate dehydrogenase is part of the Pathway/BioSystem: TCA cycle
Pssm-ID: 440241 Cd Length: 346 Bit Score: 424.81 E-value: 3.46e-149
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322097 23 SLTIGLIPGDGIGKEVIPAGKQVLENLNSKHGLSFNFIDLYAGFQTFQETGKALPDETVKVLKEqCQGALFGAVQSPttK 102
Cdd:COG0473 1 TYKIAVLPGDGIGPEVVAAALKVLEAAAERFGLDFEFEEADIGGAAYDKTGTPLPDETLEALRK-ADAILLGAVGGP--K 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322097 103 V---EGYSSPIVALRREMGLFANVRPVKSVEG-------EKGKPIDMVIVRENTEDLYIKIEKtYIDKATGTRVADATKR 172
Cdd:COG0473 78 WddgVRPESGLLALRKELDLYANLRPAKLYPGlpsplkpEIVEGIDLVIVRENTEGLYFGIGG-RIGTGTGEEVAIDTRV 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322097 173 ISEIATRRIATIALDIALKRlqtRGQatLTVTHKSNVLSQSDGLFREICKEVYEsnkdKYGQIKYNEQIVDSMVYRLFRE 252
Cdd:COG0473 157 YTRKGIERIARYAFELARKR---RKK--VTSVDKANVLKLTSGLWREVVREVAK----EYPDVELDHMYVDAAAMQLVRN 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322097 253 PQCFDVIVAPNLYGDILSDGAAALVGSLGVVPSANVGPEIV-IGEPCHGSAPDIAGKGIANPIATIRSTALMLEFLGHNE 331
Cdd:COG0473 228 PEQFDVIVTENLFGDILSDLAAGLTGSLGLAPSANIGDEGKaLFEPVHGSAPDIAGKGIANPIATILSAAMMLRHLGEEE 307
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 6322097 332 AAQDIYKAVDANLREGsIKTPDLGGKASTQQVVDDVLSRL 371
Cdd:COG0473 308 AADAIEAAVEKVLAEG-VRTPDLGGKAGTSEMGDAIIAAL 346
|
|
| Iso_dh |
pfam00180 |
Isocitrate/isopropylmalate dehydrogenase; |
25-367 |
5.90e-146 |
|
Isocitrate/isopropylmalate dehydrogenase;
Pssm-ID: 425507 Cd Length: 346 Bit Score: 416.70 E-value: 5.90e-146
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322097 25 TIGLIPGDGIGKEVIPAGKQVLENLNSKHGLSFNFIDLYAGFQTFQETGKALPDETVKVLKEQcQGALFGAVQSPTT--- 101
Cdd:pfam00180 1 KIAVLPGDGIGPEVMAAALKVLKAALEKAPLEFEFEERDVGGAAIDETGEPLPDETLEACKKA-DAVLLGAVGGPKWdpa 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322097 102 KVEGYSSpIVALRREMGLFANVRPVKSVEGEKGKP--------IDMVIVRENTEDLYIKIEKTYIDKatGTRVADATKRI 173
Cdd:pfam00180 80 GVRPENG-LLALRKELGLFANLRPAKVFPPLGDASplknevegVDIVIVRELTGGIYFGIEKGIKGS--GNEVAVDTKLY 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322097 174 SEIATRRIATIALDIALKRlqtrGQATLTVTHKSNVLSQSDgLFREICKEVYesnKDKYGQIKYNEQIVDSMVYRLFREP 253
Cdd:pfam00180 157 SRDEIERIARVAFELARKR----GRKKVTSVDKANVLKSSD-LWRKIVTEVA---KAEYPDVELEHQLVDNAAMQLVKNP 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322097 254 QCFDVIVAPNLYGDILSDGAAALVGSLGVVPSANVGP-EIVIGEPCHGSAPDIAGKGIANPIATIRSTALMLEF-LGHNE 331
Cdd:pfam00180 229 SQFDVIVTPNLFGDILSDEASMLTGSLGLLPSASLGAnGFGIFEPVHGSAPDIAGKGIANPIATILSAAMMLRYsLGLED 308
|
330 340 350
....*....|....*....|....*....|....*....
gi 6322097 332 AAQDIYKAVDANLREGsIKTPDLGGKA---STQQVVDDV 367
Cdd:pfam00180 309 AADKIEAAVLKVLESG-IRTGDLAGSAtyvSTSEFGEAV 346
|
|
| AksF2_Meth |
NF040626 |
homoisocitrate dehydrogenase; |
25-371 |
2.85e-118 |
|
homoisocitrate dehydrogenase;
Pssm-ID: 468598 Cd Length: 332 Bit Score: 345.95 E-value: 2.85e-118
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322097 25 TIGLIPGDGIGKEVIPAGKQVLENLNskhgLSFNFIDLYAGFQTFQETGKALPDETVKVLKeQCQGALFGAVqsptTKVE 104
Cdd:NF040626 3 KITVIPGDGIGKEVMEAALYVLDALD----LNFDFIEAEAGRECFKKNGTTIPEETIKIAK-KSDATLFGAV----TSTP 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322097 105 GYSSPIVALRREMGLFANVRPVKSVEGEKG--KPIDMVIVRENTEDLYIKIEKTYIDKAtgtrvADATKRISEIATRRIA 182
Cdd:NF040626 74 GQKSPIITLRKELDLYANLRPIKSYEGINClfKDLDFLIVRENTEGLYSGLEEEYTEEK-----AIAERVITRKASERIC 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322097 183 TIALDIALKRlqtrGQATLTVTHKSNVLSQSDGLFREICKEVYEsnkdKYGQIKYNEQIVDSMVYRLFREPQCFDVIVAP 262
Cdd:NF040626 149 KFAFEYAIKL----GRKKVTAVHKANVLKKTDGIFKDTFYKVAK----DYPQIETEDYYVDATAMYLITKPQDFDVIVTT 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322097 263 NLYGDILSDGAAALVGSLGVVPSANVGPEIVIGEPCHGSAPDIAGKGIANPIATIRSTALMLEFLGHNEAAQDIYKAVDA 342
Cdd:NF040626 221 NLFGDILSDEAAGLVGGLGLAPSANIGDKNGLFEPVHGSAPDIAGKNIANPIAMILSASMMLDYLGETYEANKLENALEK 300
|
330 340
....*....|....*....|....*....
gi 6322097 343 NLREGSIKTPDLGGKASTQQVVDDVLSRL 371
Cdd:NF040626 301 VLREGKVVTPDLGGNAKTMEMANEIKKKI 329
|
|
| PRK14025 |
PRK14025 |
multifunctional 3-isopropylmalate dehydrogenase/D-malate dehydrogenase; Provisional |
26-371 |
1.01e-114 |
|
multifunctional 3-isopropylmalate dehydrogenase/D-malate dehydrogenase; Provisional
Pssm-ID: 184462 Cd Length: 330 Bit Score: 336.72 E-value: 1.01e-114
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322097 26 IGLIPGDGIGKEVIPAGKQVLENLnskhGLSFNFIDLYAGFQTFQETGKALPDETVKVLKEqCQGALFGAVQspttkvEG 105
Cdd:PRK14025 4 ICVIEGDGIGKEVVPAALHVLEAT----GLPFEFVYAEAGDEVFEKTGKALPEETIEAAKE-ADAVLFGAAG------ET 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322097 106 YSSPIVALRREMGLFANVRPVKSVEGEK--GKPIDMVIVRENTEDLYIKIEKtyidkATGTRVADATKRISEIATRRIAT 183
Cdd:PRK14025 73 AADVIVKLRRILDTYANVRPVKSYKGVKclYPDIDYVIVRENTEGLYKGIEA-----EIADGVTVATRVITRKASERIFR 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322097 184 IALDIALKRLQTRGQATLTVTHKSNVLSQSDGLFREICKEVYEsnkdKYGQIKYNEQIVDSMVYRLFREPQCFDVIVAPN 263
Cdd:PRK14025 148 FAFEMAKRRKKMGKEGKVTCAHKANVLKKTDGLFKKTFYEVAK----EYPDIKAEDYYVDAMNMYIITRPQTFDVVVTSN 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322097 264 LYGDILSDGAAALVGSLGVVPSANVGPEIVIGEPCHGSAPDIAGKGIANPIATIRSTALMLEFLGHNEAAQDIYKAVDAN 343
Cdd:PRK14025 224 LFGDILSDGAAGLVGGLGLAPSANIGDKYGLFEPVHGSAPDIAGKGIANPTATILTAVLMLRHLGENEEADKVEKALEEV 303
|
330 340
....*....|....*....|....*...
gi 6322097 344 LREGsIKTPDLGGKASTQQVVDDVLSRL 371
Cdd:PRK14025 304 LALG-LTTPDLGGNLSTMEMAEEVAKRV 330
|
|
| LEU3_arch |
TIGR02088 |
isopropylmalate/isohomocitrate dehydrogenases; This model represents a group of archaeal ... |
26-368 |
1.65e-111 |
|
isopropylmalate/isohomocitrate dehydrogenases; This model represents a group of archaeal decarboxylating dehydrogenases which include the leucine biosynthesis enzyme 3-isopropylmalate dehydrogenase (LeuB, LEU3) and the methanogenic cofactor CoB biosynthesis enzyme isohomocitrate dehydrogenase (AksF). Both of these have been characterized in Methanococcus janaschii. Non-methanogenic archaea have only one hit to this model and presumably this is LeuB, although phylogenetic trees cannot establish which gene is which in the methanogens. The AksF gene is capable of acting on isohomocitrate, iso(homo)2-citrate and iso(homo)3-citrate in the successive elongation cycles of coenzyme B (7-mercaptoheptanoyl-threonine phosphate). This family is closely related to both the LeuB genes found in TIGR00169 and the mitochondrial eukaryotic isocitrate dehydratases found in TIGR00175. All of these are included within the broader subfamily model, pfam00180.
Pssm-ID: 273962 Cd Length: 322 Bit Score: 328.26 E-value: 1.65e-111
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322097 26 IGLIPGDGIGKEVIPAGKQVLEnlnsKHGLSFNFIDLYAGFQTFQETGKALPDETVKVLKEqCQGALFGAVQspTTKVEG 105
Cdd:TIGR02088 1 VAVIPGDGIGPEVIEAAIRILN----KLGLEIEFIEFEAGDEALKKYGSALPEDTLEEIRK-ADAILFGAVT--TPANPG 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322097 106 YSSPIVALRREMGLFANVRPVKSVEGEKGKP---IDMVIVRENTEDLYIKIEKTYIDKATGTRVadatkrISEIATRRIA 182
Cdd:TIGR02088 74 YKSVIVTLRKELDLYANVRPAKSLPGIPDLYpngKDIVIVRENTEGLYAGFEFGFSDRAIAIRV------ITREGSERIA 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322097 183 TIALDIALKRlqtrgQATLTVTHKSNVLSQSDGLFREICKEVYESnkdkYGqIKYNEQIVDSMVYRLFREPQCFDVIVAP 262
Cdd:TIGR02088 148 RFAFNLAKER-----NRKVTCVHKANVLKGTDGLFREVCREIAKR----YG-VEYRDMYVDSAAMNLVKDPWRFDVIVTT 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322097 263 NLYGDILSDGAAALVGSLGVVPSANVGPEIVIGEPCHGSAPDIAGKGIANPIATIRSTALMLEFLGHNEAAQDIYKAVDA 342
Cdd:TIGR02088 218 NMFGDILSDLASALAGSLGLAPSANIGDRKALFEPVHGSAPDIAGKGIANPTAAILSVAMMLDYLGELEKGKLVWEAVEY 297
|
330 340
....*....|....*....|....*.
gi 6322097 343 NLREGSiKTPDLGGKASTQQVVDDVL 368
Cdd:TIGR02088 298 YIIEGK-KTPDLGGTAKTKEVGDEIA 322
|
|
| PRK00772 |
PRK00772 |
3-isopropylmalate dehydrogenase; Provisional |
22-371 |
4.77e-101 |
|
3-isopropylmalate dehydrogenase; Provisional
Pssm-ID: 234832 Cd Length: 358 Bit Score: 302.79 E-value: 4.77e-101
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322097 22 KSLTIGLIPGDGIGKEVIPAGKQVLENLNSKHGLSFNFIDLYAGFQTFQETGKALPDETVkvlkEQCQGA---LFGAVQS 98
Cdd:PRK00772 1 MTYKIAVLPGDGIGPEVMAEAVKVLDAVAEKFGFDFEFEEALVGGAAIDAHGVPLPEETL----EACRAAdavLLGAVGG 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322097 99 PttKVEGYSSP------IVALRREMGLFANVRPVKSVEGEKG----KP-----IDMVIVRENTEDLYIKiEKTYIDKATG 163
Cdd:PRK00772 77 P--KWDNLPPDvrpergLLALRKELGLFANLRPAKLYPGLADasplKPeivagLDILIVRELTGGIYFG-EPRGREGLGG 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322097 164 TRVADATKRISEIATRRIATIALDIALKRlqtRGQatLTVTHKSNVLsQSDGLFREICKEVyesnKDKYGQIKYNEQIVD 243
Cdd:PRK00772 154 EERAFDTMVYTREEIERIARVAFELARKR---RKK--VTSVDKANVL-ESSRLWREVVTEV----AKEYPDVELSHMYVD 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322097 244 SMVYRLFREPQCFDVIVAPNLYGDILSDGAAALVGSLGVVPSANVGPE-IVIGEPCHGSAPDIAGKGIANPIATIRSTAL 322
Cdd:PRK00772 224 NAAMQLVRNPKQFDVIVTENLFGDILSDEAAMLTGSLGMLPSASLGESgPGLYEPIHGSAPDIAGKGIANPIATILSAAM 303
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 6322097 323 MLEF-LGHNEAAQDIYKAVDANLREGsIKTPDL---GGKASTQQVVDDVLSRL 371
Cdd:PRK00772 304 MLRYsLGLEEAADAIEAAVEKVLAQG-YRTADIaegGGKVSTSEMGDAILAAL 355
|
|
| AksF_Meth |
NF040619 |
homoisocitrate dehydrogenase; |
26-367 |
8.54e-100 |
|
homoisocitrate dehydrogenase;
Pssm-ID: 468591 Cd Length: 332 Bit Score: 298.98 E-value: 8.54e-100
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322097 26 IGLIPGDGIGKEVIPAGKQVLENLNSkhglsFNFIDLYAGFQTFQETGKALPDETVKVLKEqCQGALFGAVQSPT---TK 102
Cdd:NF040619 4 ICVIEGDGIGKEVIPETVRVLKELGD-----FEFIKGEAGLECFKKYGDAIPEETIEKAKE-CDAILFGAVTTPKpteLK 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322097 103 VEGYSSPIVALRREMGLFANVRPVKSV-EGEKGKPIDMVIVRENTEDLYIKIEKtYIDKatgTRVADATKRISEIATRRI 181
Cdd:NF040619 78 NKNYKSPILTLRKELDLYANVRPINNFgDGQDVKNIDFVIIRENTEGLYVGREY-YDEE---NEIAIAERIISKKGSERI 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322097 182 ATIALDIALKRLQTRgqatLTVTHKSNVLSQSDGLFREICKEVYESNKDKygQIKYNEQIVDSMVYRLFREPQCFDVIVA 261
Cdd:NF040619 154 IKFAFEYAKKNNRKK----VSCIHKANVLRVTDGLFLEIFNEIKKKYKNF--NIEADDYLVDATAMYLIKNPEMFDVIVT 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322097 262 PNLYGDILSDGAAALVGSLGVVPSANVGPEIVIGEPCHGSAPDIAGKGIANPIATIRSTALMLEFLGHNEAAQDIYKAVD 341
Cdd:NF040619 228 TNLFGDILSDEASGLIGGLGLAPSANIGDKKGLFEPVHGSAPDIAGKGIANPIATILSAAMMLDYLGMKEKGDLIREAVK 307
|
330 340
....*....|....*....|....*.
gi 6322097 342 ANLREGSIkTPDLGGKASTQQVVDDV 367
Cdd:NF040619 308 KCLENGKV-TPDLGGNLKTKEVTDKI 332
|
|
| mito_nad_idh |
TIGR00175 |
isocitrate dehydrogenase, NAD-dependent, mitochondrial type; Several NAD- or NADP-dependent ... |
24-371 |
2.58e-88 |
|
isocitrate dehydrogenase, NAD-dependent, mitochondrial type; Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the multimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; the latter carbon, now adjacent to a carbonyl group, readily decarboxylates. Mitochondrial NAD-dependent isocitrate dehydrogenases (IDH) resemble prokaryotic NADP-dependent IDH and 3-isopropylmalate dehydrogenase (an NAD-dependent enzyme) more closely than they resemble eukaryotic NADP-dependent IDH. The mitochondrial NAD-dependent isocitrate dehydrogenase is believed to be an alpha(2)-beta-gamma heterotetramer. All subunits are homologous and found by this model. The NADP-dependent IDH of Thermus aquaticus thermophilus strain HB8 resembles these NAD-dependent IDH, except for the residues involved in cofactor specificity, much more closely than it resembles other prokaryotic NADP-dependent IDH, including that of Thermus aquaticus strain YT1. [Energy metabolism, TCA cycle]
Pssm-ID: 272942 Cd Length: 333 Bit Score: 269.64 E-value: 2.58e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322097 24 LTIGLIPGDGIGKEVIPAGKQVLENLNSKhgLSFNFIDLYAgfqtFQETGKALPDETVKVLKEQcQGALFGAVQSPTTKV 103
Cdd:TIGR00175 4 YTVTLIPGDGIGPEISGSVKKIFRAANVP--IEFEEIDVSP----QTDGKTEIPDEAVESIKRN-KVALKGPLETPIGKG 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322097 104 eGYSSPIVALRREMGLFANVRPVKSVEGEKG--KPIDMVIVRENTEDLYIKIEKTYIDKatgtrVADATKRISEIATRRI 181
Cdd:TIGR00175 77 -GHRSLNVALRKELDLYANVVHCKSLPGFKTrhEDVDIVIIRENTEGEYSGLEHESVPG-----VVESLKVITRDKSERI 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322097 182 ATIALDIALKRlqtrGQATLTVTHKSNVLSQSDGLFREICKEVYEsnkdKYGQIKYNEQIVDSMVYRLFREPQCFDVIVA 261
Cdd:TIGR00175 151 ARYAFEYARKN----GRKKVTAVHKANIMKLADGLFLNVCREVAK----EYPDITFESMIVDNTCMQLVSRPSQFDVMVM 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322097 262 PNLYGDILSDGAAALVGSLGVVPSANVGPEIVIGEP-CHGSAPDIAGKGIANPIATIRSTALMLEFLGHNEAAQDIYKAV 340
Cdd:TIGR00175 223 PNLYGNILSNLGAGLVGGPGLVPGANIGRDYAVFEPgVRHTGPDIAGQNIANPTALILSSVMMLNHLGLKEHADRIQKAV 302
|
330 340 350
....*....|....*....|....*....|.
gi 6322097 341 DANLREGSIKTPDLGGKASTQQVVDDVLSRL 371
Cdd:TIGR00175 303 LSTIAEGKNRTKDLGGTATTSDFTEAVIKRL 333
|
|
| PRK08997 |
PRK08997 |
isocitrate dehydrogenase; Provisional |
25-371 |
9.05e-86 |
|
isocitrate dehydrogenase; Provisional
Pssm-ID: 181606 Cd Length: 334 Bit Score: 263.12 E-value: 9.05e-86
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322097 25 TIGLIPGDGIGKEVIPAGKQVLENLNSkhGLSFNFIDlyAGFQTFQETGKALPDETVKVLkEQCQGALFGAVQSPTTkvE 104
Cdd:PRK08997 4 TITVIPGDGIGPSIIDATLKILDKLGC--DFEYEFAD--AGLTALEKHGELLPQRTLDLI-EKNKIALKGPLTTPVG--E 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322097 105 GYSSPIVALRREMGLFANVRPVKSVEGEKGK--PIDMVIVRENTEDLYIKIEKTYIDKATgtrVADATKRISEIATRRIA 182
Cdd:PRK08997 77 GFTSINVTLRKKFDLYANVRPVLSFPGTKARydNIDIITVRENTEGMYSGEGQTVSEDGE---TAEATSIITRKGAERIV 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322097 183 TIALDIALKRlqtrGQATLTVTHKSNVLSQSDGLFREICKEVYEsnkdKYGQIKYNEQIVDSMVYRLFREPQCFDVIVAP 262
Cdd:PRK08997 154 RFAYELARKE----GRKKVTAVHKANIMKSTSGLFLKVAREVAL----RYPDIEFEEMIVDATCMQLVMNPEQFDVIVTT 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322097 263 NLYGDILSDGAAALVGSLGVVPSANVGPEIVIGEPCHGSAPDIAGKGIANPIATIRSTALMLEFLGHNEAAQDIYKAVDA 342
Cdd:PRK08997 226 NLFGDILSDLCAGLVGGLGMAPGANIGRDAAIFEAVHGSAPDIAGKNLANPTSVILAAIQMLEYLGMPDKAERIRKAIVA 305
|
330 340
....*....|....*....|....*....
gi 6322097 343 NLREGSIKTPDLGGKASTQQVVDDVLSRL 371
Cdd:PRK08997 306 VIEAGDRTTRDLGGTHGTTDFTQAVIDRL 334
|
|
| TTC |
TIGR02089 |
tartrate dehydrogenase; Tartrate dehydrogenase catalyzes the oxidation of both meso- and (+) ... |
22-371 |
1.19e-83 |
|
tartrate dehydrogenase; Tartrate dehydrogenase catalyzes the oxidation of both meso- and (+)-tartrate as well as a D-malate. These enzymes are closely related to the 3-isopropylmalate and isohomocitrate dehydrogenases found in TIGR00169 and TIGR02088, respectively. [Energy metabolism, Other]
Pssm-ID: 273963 Cd Length: 352 Bit Score: 258.23 E-value: 1.19e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322097 22 KSLTIGLIPGDGIGKEVIPAGKQVLENLNSKHG-LSFNFIDLYAGFQTFQETGKALPDETVKVLKeQCQGALFGAVQSPT 100
Cdd:TIGR02089 2 KQYRIAAIPGDGIGKEVVAAALQVLEAAAKRHGgFSLHFTEFPWSCDYYKEHGKMMPEDGLEKLK-KFDAIFLGAVGWPA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322097 101 tKVEGYSS---PIVALRREMGLFANVRPVKSVEGEKG-------KPIDMVIVRENTEDLYIKIEKTyIDKATGTRVADAT 170
Cdd:TIGR02089 81 -LVPDHISlwgLLLKIRREFDQYANVRPAKLLPGVTSplrncgpGDFDFVVVRENSEGEYSGVGGR-IHRGTDEEVATQN 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322097 171 KRISEIATRRIATIALDIALKRlqtrgQATLTVTHKSNVLSQSDGLFREICKEVyesnKDKYGQIKYNEQIVDSMVYRLF 250
Cdd:TIGR02089 159 AIFTRKGVERIMRFAFELAQKR-----RKHLTSATKSNGIRHSMPFWDEVFAEV----AAEYPDVEWDSYHIDALAARFV 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322097 251 REPQCFDVIVAPNLYGDILSDGAAALVGSLGVVPSANVGPE---IVIGEPCHGSAPDIAGKGIANPIATIRSTALMLEFL 327
Cdd:TIGR02089 230 LKPETFDVIVASNLFGDILSDLGAALMGSLGVAPSANINPEgkfPSMFEPVHGSAPDIAGKGIANPIGAIWTAAMMLEHL 309
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 6322097 328 GHNEAAQDIYKAVDANLREGsIKTPDLGGKASTQQVVDDVLSRL 371
Cdd:TIGR02089 310 GEKEAGAKIMDAIERVTAAG-ILTPDVGGKATTSEVTEAVCNAL 352
|
|
| leuB |
TIGR00169 |
3-isopropylmalate dehydrogenase; Several NAD- or NADP-dependent dehydrogenases, including ... |
26-371 |
1.50e-74 |
|
3-isopropylmalate dehydrogenase; Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the dimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; the latter carbon, now adjacent to a carbonyl group, readily decarboxylates.Among these decarboxylating dehydrogenases of hydroxyacids, overall sequence homology indicates evolutionary history rather than actual substrate or cofactor specifity, which may be toggled experimentally by replacement of just a few amino acids. 3-isopropylmalate dehydrogenase is an NAD-dependent enzyme and should have a sequence resembling HGSAPDI around residue 340. The subtrate binding loop should include a sequence resembling E[KQR]X(0,1)LLXXR around residue 115. Other contacts of importance are known from crystallography but not detailed here.This model will not find all isopropylmalate dehydrogenases; the enzyme from Sulfolobus sp. strain 7 is more similar to mitochondrial NAD-dependent isocitrate dehydrogenases than to other known isopropylmalate dehydrogenases and was omitted to improve the specificity of the model. It scores below the cutoff and below some enzymes known not to be isopropylmalate dehydrogenase. [Amino acid biosynthesis, Pyruvate family]
Pssm-ID: 272939 Cd Length: 346 Bit Score: 234.60 E-value: 1.50e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322097 26 IGLIPGDGIGKEVIPAGKQVLENLNSKHGLSFNFIDLYAGFQTFQETGKALPDETVKVLKEqCQGALFGAVQSPttKVEG 105
Cdd:TIGR00169 2 IAVLPGDGIGPEVMAQALKVLKAVAERFGLKFEFEEHLIGGAAIDATGQPLPEETLKGCKE-ADAVLLGAVGGP--KWDN 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322097 106 YSSPI------VALRREMGLFANVRPVKSVEG-EKGKPI--------DMVIVRENTEDLYIKIEKtyidKATGTRVADAT 170
Cdd:TIGR00169 79 LPRDQrpeqglLKLRKSLDLFANLRPAKVFPGlEDLSPLkeeiakgvDFVVVRELTGGIYFGEPK----GREGEGEAWDT 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322097 171 KRISEIATRRIATIALDIALKRlqtRGQatLTVTHKSNVLsQSDGLFREICKEVYEsnkdKYGQIKYNEQIVDSMVYRLF 250
Cdd:TIGR00169 155 EVYTVPEIERIARVAFEMARKR---RKK--VTSVDKANVL-ESSRLWRKTVEEIAK----EYPDVELEHQYIDNAAMQLV 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322097 251 REPQCFDVIVAPNLYGDILSDGAAALVGSLGVVPSANVGPE-IVIGEPCHGSAPDIAGKGIANPIATIRSTALMLEF-LG 328
Cdd:TIGR00169 225 KSPTQFDVVVTSNLFGDILSDEASVITGSLGMLPSASLGSDgFGLFEPVHGSAPDIAGKGIANPIAQILSAAMLLRYsFN 304
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 6322097 329 HNEAAQDIYKAVDANLREGsIKTPDLGGKASTQQVVDDVLSRL 371
Cdd:TIGR00169 305 LEEAADAIEAAVKKVLAEG-YRTPDLGSSATTAVGTAEMGEEL 346
|
|
| PRK08194 |
PRK08194 |
tartrate dehydrogenase; Provisional |
22-371 |
4.43e-72 |
|
tartrate dehydrogenase; Provisional
Pssm-ID: 181281 Cd Length: 352 Bit Score: 228.45 E-value: 4.43e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322097 22 KSLTIGLIPGDGIGKEVIPAGKQVLENLNSKHG-LSFNFIDLYAGFQTFQETGKALPDETVKVLKeQCQGALFGAVQSPT 100
Cdd:PRK08194 2 KQFKIAVIPGDGVGKEVVPAAVRVLKAVAEVHGgLKFEFTEFPWSCEYYLEHGEMMPEDGLEQLK-QFDAIFLGAVGNPK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322097 101 TKVEGYS--SPIVALRREMGLFANVRPVKSVEGEKG-----KPIDMVIVRENTEDLYIKI--------EKTYIDKATGTR 165
Cdd:PRK08194 81 LVPDHISlwGLLIKIRREFEQVINIRPAKQLRGIKSplanpKDFDLLVVRENSEGEYSEVggrihrgeDEIAIQNAVFTR 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322097 166 VAdatkriseiaTRRIATIALDIALKRlqtRGQatLTVTHKSNVLSQSDGLFREICKEVYESnkdkYGQIKYNEQIVDSM 245
Cdd:PRK08194 161 KG----------TERAMRYAFELAAKR---RKH--VTSATKSNGIVHSMPFWDEVFQEVGKD----YPEIETDSQHIDAL 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322097 246 VYRLFREPQCFDVIVAPNLYGDILSDGAAALVGSLGVVPSANVGPE---IVIGEPCHGSAPDIAGKGIANPIATIRSTAL 322
Cdd:PRK08194 222 AAFFVTRPEEFDVIVASNLFGDILTDIGAAIMGSIGIAPAANINVNgkyPSMFEPVHGSAPDIAGKGIANPIGQIWTAKL 301
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 6322097 323 MLEFLGHNEAAQDIYKAVDANLREGsIKTPDLGGKASTQQVVDDVLSRL 371
Cdd:PRK08194 302 MLDHFGEEELGSHLLDVIEDVTEDG-IKTPDIGGRATTDEVTDEIISRL 349
|
|
| Icd |
COG0538 |
Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part ... |
25-354 |
8.32e-71 |
|
Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part of the Pathway/BioSystem: TCA cycle
Pssm-ID: 440304 Cd Length: 409 Bit Score: 226.92 E-value: 8.32e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322097 25 TIGLIPGDGIGKEVIPAGKQVL-ENLNSKHG--LSFNFIDLYAGFQTFQETGKALPDETVKVLKEqcqgalFG-AVQSP- 99
Cdd:COG0538 20 IIPFIEGDGIGPEITRAIWKVIdAAVEKAYGgkRDIEWKEVDAGEKARDETGDWLPDETAEAIKE------YGvGIKGPl 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322097 100 TTKVE-GYSSPIVALRREMGLFANVRPVKSVEG--------EKgkpIDMVIVRENTEDLYIKIE--------KTYID--- 159
Cdd:COG0538 94 TTPVGgGWRSLNVTIRQILDLYVCRRPVRYFKGvpspvkhpEK---VDIVIFRENTEDIYAGIEwkagspeaLKLIFfle 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322097 160 ---KATGTRVAD----ATKRISEIATRRIATIALDIALKRlqtrGQATLTVTHKSNVLSQSDGLFREICKEVYES----- 227
Cdd:COG0538 171 demGVTVIRFPEdsgiGIKPVSDEGTERLVRAAIQYALDN----KRKSVTLVHKGNIMKFTEGAFKDWGYEVAEEefgdk 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322097 228 -----------NKDKYGQIKYNEQIVDSMVYRLFREPQCFDVIVAPNLYGDILSDGAAALVGSLGVVPSANVGPEI-VIG 295
Cdd:COG0538 247 fitegpwekykGPKPAGKIVYKDRIADDMLQQILLRPGEYDVIATKNLNGDYISDALAAQVGGLGIAPGANIGDDGgAEF 326
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 6322097 296 EPCHGSAPDIAGKGIANPIATIRSTALMLEFLGHNEAAQDIYKAVDANLREGSIkTPDL 354
Cdd:COG0538 327 EATHGTAPKYAGKDSTNPGSLILSGTMMLRHRGWLEAADLIEKAVEKTIESGKV-TYDL 384
|
|
| PLN00118 |
PLN00118 |
isocitrate dehydrogenase (NAD+) |
10-371 |
2.69e-70 |
|
isocitrate dehydrogenase (NAD+)
Pssm-ID: 215062 Cd Length: 372 Bit Score: 224.76 E-value: 2.69e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322097 10 SACRGLASnaARKSLTIGLIPGDGIGKEVIPAGKQVLENLnskhGLSFNFIDLYAGFQTFQETGKALPDETVKVLKeQCQ 89
Cdd:PLN00118 30 SSARAFSS--SSTPITATLFPGDGIGPEIAESVKQVFTAA----GVPIEWEEHYVGTTVDPRTGSFLTWESLESVR-RNK 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322097 90 GALFGAVQSPTTKveGYSSPIVALRREMGLFANVRPVKSVEGEKGK--PIDMVIVRENTEDLYIKIEKTYIDKatgtrVA 167
Cdd:PLN00118 103 VGLKGPMATPIGK--GHRSLNLTLRKELGLYANVRPCYSLPGYKTRydDVDLVTIRENTEGEYSGLEHQVVRG-----VV 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322097 168 DATKRISEIATRRIATIALDIAlkrlQTRGQATLTVTHKSNVLSQSDGLFREICKEVYEsnkdKYGQIKYNEQIVDSMVY 247
Cdd:PLN00118 176 ESLKIITRQASLRVAEYAFHYA----KTHGRKRVSAIHKANIMKKTDGLFLKCCREVAE----KYPEIVYEEVIIDNCCM 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322097 248 RLFREPQCFDVIVAPNLYGDILSDGAAALVGSLGVVPSANVGPE-IVIGEPCHGSAPDIAGKGIANPIATIRSTALMLEF 326
Cdd:PLN00118 248 MLVKNPALFDVLVMPNLYGDIISDLCAGLIGGLGLTPSCNIGENgLALAEAVHGSAPDIAGKNLANPTALLLSAVMMLRH 327
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 6322097 327 LGHNEAAQDIYKAVDANLREGSIKTPDLGGKASTQQVVDDVLSRL 371
Cdd:PLN00118 328 LKLNEQAEQIHNAILNTIAEGKYRTADLGGSSTTTDFTKAICDHL 372
|
|
| PRK03437 |
PRK03437 |
3-isopropylmalate dehydrogenase; Provisional |
22-371 |
1.03e-65 |
|
3-isopropylmalate dehydrogenase; Provisional
Pssm-ID: 179579 Cd Length: 344 Bit Score: 211.71 E-value: 1.03e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322097 22 KSLTIGLIPGDGIGKEVIPAGKQVLENLnSKHGLSFNFIDLYAGFQTFQETGKALPDETVKVLKEQcQGALFGAVQSPTT 101
Cdd:PRK03437 3 KTMKLAVIPGDGIGPEVVAEALKVLDAV-AAGGPGVETTEYDLGARRYLRTGETLPDSVLAELRQH-DAILLGAIGDPSV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322097 102 KvegysSPIVA------LRREMGLFANVRPVKSVEGE----KGKP-IDMVIVRENTEDLYIKIEKTyIDKATGTRVADAT 170
Cdd:PRK03437 81 P-----SGVLErglllkLRFALDHYVNLRPSKLYPGVtsplAGPGdIDFVVVREGTEGPYTGNGGA-LRVGTPHEVATEV 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322097 171 krisEIATRRIATIALDIALKRLQTRGQATLTVTHKSNVLSQSDGLFREICKEVYEsnkdKYGQIKYNEQIVDSMVYRLF 250
Cdd:PRK03437 155 ----SVNTAFGVERVVRDAFERAQKRPRKHLTLVHKTNVLTFAGDLWQRTVDEVAA----EYPDVTVDYQHVDAATIFMV 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322097 251 REPQCFDVIVAPNLYGDILSDGAAALVGSLGVVPSANVGPEIVIG---EPCHGSAPDIAGKGIANPIATIRSTALMLEFL 327
Cdd:PRK03437 227 TDPSRFDVIVTDNLFGDIITDLAAAVTGGIGLAASGNINPTGTNPsmfEPVHGSAPDIAGQGIADPTAAILSVALLLDHL 306
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 6322097 328 GHNEAAQDIYKAVDANLREgsiktpDLGGKASTQQVVDDVLSRL 371
Cdd:PRK03437 307 GEEDAAARIEAAVEADLAE------RGKMGRSTAEVGDRIAARL 344
|
|
| PRK09222 |
PRK09222 |
NADP-dependent isocitrate dehydrogenase; |
20-371 |
1.59e-64 |
|
NADP-dependent isocitrate dehydrogenase;
Pssm-ID: 236416 [Multi-domain] Cd Length: 482 Bit Score: 212.83 E-value: 1.59e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322097 20 ARKSLTIGLIPGDGIGKEVIPAGKQVLENlnSKHGLSFNFIDlyAGFQTFQE---TGkaLPDETVKVLKEQcqGALfgaV 96
Cdd:PRK09222 1 MAEKTPITVAYGDGIGPEIMEAVLKILEA--AGAPLEIETIE--IGEKVYKKgwtSG--ISPSAWESIRRT--KVL---L 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322097 97 QSPTT--KVEGYSSPIVALRREMGLFANVRPVKS---VEGEKGKPIDMVIVRENTEDLYIKIEKtyidKATGTrVADATK 171
Cdd:PRK09222 70 KAPITtpQGGGYKSLNVTLRKTLGLYANVRPCVSyhpFVETKHPNLDVVIIRENEEDLYAGIEH----RQTPD-VYQCLK 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322097 172 RISEIATRRIATIALDIALKRlqtrGQATLTVTHKSNVLSQSDGLFREICKEVYEsnkdKYGQIKYNEQIVDSMVYRLFR 251
Cdd:PRK09222 145 LISRPGSEKIIRYAFEYARAN----GRKKVTCLTKDNIMKLTDGLFHKVFDEIAK----EYPDIEAEHYIVDIGAARLAT 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322097 252 EPQCFDVIVAPNLYGDILSDGAAALVGSLGVVPSANVGPEIVIGEPCHGSAPDIAGKGIANPIATIRSTALMLEFLGHNE 331
Cdd:PRK09222 217 NPENFDVIVTPNLYGDILSDIAAEISGSVGLAGSANIGEEYAMFEAVHGSAPDIAGKNIANPSGLLNAAVMMLVHIGQFD 296
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 6322097 332 AAQDIYKAVDANLREGsIKTPDLGG------KASTQQVVDDVLSRL 371
Cdd:PRK09222 297 IAELIENAWLKTLEDG-IHTADIYNegvskkKVGTKEFAEAVIENL 341
|
|
| PRK06451 |
PRK06451 |
NADP-dependent isocitrate dehydrogenase; |
29-354 |
7.36e-64 |
|
NADP-dependent isocitrate dehydrogenase;
Pssm-ID: 235803 Cd Length: 412 Bit Score: 209.30 E-value: 7.36e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322097 29 IPGDGIGKEVIPAGKQVLENLNSKHGLS---FNFIDLYAGFQTFQETGKALPDETVKVLkEQCQGALFGAVQSPTTKveG 105
Cdd:PRK06451 29 VEGDGIGPEITHAAMKVINKAVEKAYGSdreIKWVEVLAGDKAEKLTGNRFPKESEELI-EKYRVLLKGPLETPIGK--G 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322097 106 YSSPIVALRREMGLFANVRPVKSVEG-----EKGKPIDMVIVRENTEDLYIKIEKTY-----------IDKATGTRVADA 169
Cdd:PRK06451 106 WKSINVAIRLMLDLYANIRPVKYIPGiesplKNPEKIDLIIFRENTDDLYRGIEYPYdseeakkirdfLRKELGVEVEDD 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322097 170 T----KRISEIATRRIATIALDIALKRlqtrGQATLTVTHKSNVLSQSDGLFREICKEVY------------ESNKDKYG 233
Cdd:PRK06451 186 TgigiKLISKFKTQRIARMAIKYAIDH----KRKKVTIMHKGNVMKYTEGAFREWAYEVAlkefrdyvvteeEVTKNYNG 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322097 234 -----QIKYNEQIVDSMVYRLFREPQCFDVIVAPNLYGDILSDGAAALVGSLGVVPSANVGPEIVIGEPCHGSAPDIAGK 308
Cdd:PRK06451 262 vppsgKVIINDRIADNMFQQIIIRPDEYDIILAPNVNGDYISDAAGALVGNIGMLGGANIGDTGGMFEAIHGTAPKYAGK 341
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 6322097 309 GIANPIATIRSTALMLEFLGHNEAAQDIYKAVDANLREGSIkTPDL 354
Cdd:PRK06451 342 NVANPTGIIKGGELMLRFMGWDKAADLIDKAIMESIKQKKV-TQDL 386
|
|
| PLN00123 |
PLN00123 |
isocitrate dehydrogenase (NAD+) |
25-371 |
2.43e-56 |
|
isocitrate dehydrogenase (NAD+)
Pssm-ID: 215065 Cd Length: 360 Bit Score: 188.15 E-value: 2.43e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322097 25 TIGLIPGDGIGKEVIPAGKQVLENLNSKhglsfnfidLYagFQTFQETG--KALPDETVKVLKEQ--C-QGALFGAVQSp 99
Cdd:PLN00123 32 AVTLIPGDGIGPLVTGAVEQVMEAMHAP---------VY--FERYEVHGdmKKVPEEVLESIRRNkvClKGGLATPVGG- 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322097 100 ttkveGYSSPIVALRREMGLFANVRPVKSVEG--EKGKPIDMVIVRENTEDLYIKIEKTYIDKatgtrVADATKRISEIA 177
Cdd:PLN00123 100 -----GVSSLNVQLRKELDLFASLVNCFNLPGlpTRHENVDIVVIRENTEGEYSGLEHEVVPG-----VVESLKVITKFC 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322097 178 TRRIATIALDIALkrLQTRgqATLTVTHKSNVLSQSDGLFREICKEVYEsnkdKYGQIKYNEQIVDSMVYRLFREPQCFD 257
Cdd:PLN00123 170 SERIAKYAFEYAY--LNNR--KKVTAVHKANIMKLADGLFLESCREVAK----KYPGIKYNEIIVDNCCMQLVSKPEQFD 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322097 258 VIVAPNLYGDILSDGAAALVGSLGVVPSANVGPEIVIGEPCHGSA----PDIAGKGIANPIATIRSTALMLEFLGHNEAA 333
Cdd:PLN00123 242 VMVTPNLYGNLVANTAAGIAGGTGVMPGGNVGADHAVFEQGASAGnvgnEKLVEQKKANPVALLLSSAMMLRHLQFPSFA 321
|
330 340 350
....*....|....*....|....*....|....*...
gi 6322097 334 QDIYKAVDANLREGSIKTPDLGGKASTQQVVDDVLSRL 371
Cdd:PLN00123 322 DRLETAVKRVIAEGKYRTKDLGGSSTTQEVVDAVIANL 359
|
|
| ICDH_alpha |
TIGR02924 |
isocitrate dehydrogenase; This family of mainly alphaproteobacterial enzymes is a member of ... |
97-371 |
1.44e-54 |
|
isocitrate dehydrogenase; This family of mainly alphaproteobacterial enzymes is a member of the isocitrate/isopropylmalate dehydrogenase superfamily described by pfam00180. Every member of the seed of this model appears to have a TCA cycle lacking only a determined isocitrate dehydrogenase. The precise identity of the cofactor (NADH -- 1.1.1.41 vs. NADPH -- 1.1.1.42) is unclear. [Energy metabolism, TCA cycle]
Pssm-ID: 274353 [Multi-domain] Cd Length: 473 Bit Score: 186.51 E-value: 1.44e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322097 97 QSPTTKVEG--YSSPIVALRREMGLFANVRPVKSVEG--EKGKP-IDMVIVRENTEDLYIKIEKtyidKATGTrVADATK 171
Cdd:TIGR02924 66 KAPITTPQGggHKSLNVTLRKTLGLYANIRPCVSYHPfiETKSPnLNIVIVRENEEDLYTGIEY----RQTPD-TYECTK 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322097 172 RISEIATRRIATIALDIAlkrlQTRGQATLTVTHKSNVLSQSDGLFREICKEVYEsnkdKYGQIKYNEQIVDSMVYRLFR 251
Cdd:TIGR02924 141 LITRSGSEKICRYAFEYA----RKHNRKKVTCLTKDNIMKMTDGIFHKIFDKIAA----EYPDIESEHYIVDIGMARLAT 212
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322097 252 EPQCFDVIVAPNLYGDILSDGAAALVGSLGVVPSANVGPEIVIGEPCHGSAPDIAGKGIANPIATIRSTALMLEFLGHNE 331
Cdd:TIGR02924 213 NPENFDVIVTPNLYGDILSDVAAEISGSVGLAGSANIGEEYAMFEAVHGSAPDIAGQNIANPSGLLNAAIQMLVHIGQSD 292
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 6322097 332 AAQDIYKAVDANLREGsIKTPDL------GGKASTQQVVDDVLSRL 371
Cdd:TIGR02924 293 IAQLIYNAWLKTLEDG-VHTADIynektsKQKVGTKEFAEAVTANL 337
|
|
| PLN02329 |
PLN02329 |
3-isopropylmalate dehydrogenase |
13-371 |
1.50e-48 |
|
3-isopropylmalate dehydrogenase
Pssm-ID: 215188 Cd Length: 409 Bit Score: 169.10 E-value: 1.50e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322097 13 RGLASNAARKSLTIGLIPGDGIGKEVIPAGKQVLENLNSKHGLSFNFIDLYAGFQTFQETGKALPDETVKVLKeQCQGAL 92
Cdd:PLN02329 36 RCAAASPGKKRYNIALLPGDGIGPEVISVAKNVLQKAGSLEGLEFDFQEMPVGGAALDLVGVPLPEETFTAAK-QSDAIL 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322097 93 FGAVQS-PTTKVEGYSSPIVAL---RREMGLFANVRPV---------KSVEGEKGKPIDMVIVRENTEDLYIKIEKTYID 159
Cdd:PLN02329 115 LGAIGGyKWDKNEKHLRPEMALfylRRDLKVFANLRPAtvlpqlvdaSTLKKEVAEGVDMMIVRELTGGIYFGEPRGITI 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322097 160 KATGTRVADATKRISEIATRRIATIALDIALKRlqtRGQatLTVTHKSNVLSQSDgLFREICKEVyesnKDKYGQIKYNE 239
Cdd:PLN02329 195 NENGEEVGVSTEIYAAHEIDRIARVAFETARKR---RGK--LCSVDKANVLDASI-LWRKRVTAL----ASEYPDVELSH 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322097 240 QIVDSMVYRLFREPQCFDVIVAPNLYGDILSDGAAALVGSLGVVPSANV---GPEIVigEPCHGSAPDIAGKGIANPIAT 316
Cdd:PLN02329 265 MYVDNAAMQLIRDPKQFDTIVTNNIFGDILSDEASMITGSIGMLPSASLgesGPGLF--EPIHGSAPDIAGQDKANPLAT 342
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 6322097 317 IRSTALMLEF-LGHNEAAQDIYKAV----DANLREGSIKTPD---LGGKASTQQVVDDVLSRL 371
Cdd:PLN02329 343 ILSAAMLLKYgLGEEKAAKRIEDAVvdalNKGFRTGDIYSPGnklVGCKEMGEEVLKSVDSKV 405
|
|
| PRK07006 |
PRK07006 |
isocitrate dehydrogenase; Reviewed |
26-350 |
5.77e-48 |
|
isocitrate dehydrogenase; Reviewed
Pssm-ID: 180792 Cd Length: 409 Bit Score: 167.55 E-value: 5.77e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322097 26 IGLIPGDGIGKEVIPAGKQVLENLNSKhglSFN------FIDLYAGFQTFQETGKA--LPDETVKVLKEQCQgalfgAVQ 97
Cdd:PRK07006 22 IPFIEGDGIGPDITPAMLKVVDAAVEK---AYKgerkisWMEIYAGEKATKVYGEDvwLPEETLDLIREYRV-----AIK 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322097 98 SP-TTKVEG-YSSPIVALRREMGLFANVRPVKSVEG-----EKGKPIDMVIVRENTEDLYIKIE--------KTYID--- 159
Cdd:PRK07006 94 GPlTTPVGGgIRSLNVALRQELDLYVCLRPVRYFKGvpspvKRPEDTDMVIFRENSEDIYAGIEwkagsaeaKKVIKflq 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322097 160 ---KATGTRVADAT----KRISEIATRRIATIALDIALkrlqTRGQATLTVTHKSNVLSQSDGLFR---------EICKE 223
Cdd:PRK07006 174 eemGVKKIRFPETSgigiKPVSEEGTERLVRAAIEYAI----DNDRKSVTLVHKGNIMKFTEGAFKdwgyqlaeeEFGDE 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322097 224 VYE-------SNKDKYGQIKYNEQIVDSMVYRLFREPQCFDVIVAPNLYGDILSDGAAALVGSLGVVPSANVGPEIVIGE 296
Cdd:PRK07006 250 LIDggpwdkiKNPETGKEIIVKDSIADAFLQQILLRPAEYDVIATMNLNGDYISDALAAQVGGIGIAPGANINDGHAIFE 329
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 6322097 297 PCHGSAPDIAGKGIANPIATIRSTALMLEFLGHNEAAQDIYKAVdanlrEGSIK 350
Cdd:PRK07006 330 ATHGTAPKYAGLDKVNPGSVILSAEMMLRHMGWTEAADLIIKSM-----EKTIA 378
|
|
| PRK07362 |
PRK07362 |
NADP-dependent isocitrate dehydrogenase; |
26-354 |
5.04e-34 |
|
NADP-dependent isocitrate dehydrogenase;
Pssm-ID: 180944 Cd Length: 474 Bit Score: 130.99 E-value: 5.04e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322097 26 IGLIPGDGIGKEVIPAGKQVLENLNSK-HG--LSFNFIDLYAG------FQTFQetgkALPDETVKVLKEqcqgalFG-A 95
Cdd:PRK07362 31 IPFIRGDGTGVDIWPATQKVLDAAVAKaYGgeRKINWFKVYAGdeacdlYGTYQ----YLPEDTLEAIRE------YGvA 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322097 96 VQSP-TTKVEG-YSSPIVALRREMGLFANVRPVKSVEG-----EKGKPIDMVIVRENTEDLYIKIE-------------- 154
Cdd:PRK07362 101 IKGPlTTPIGGgIRSLNVALRQIFDLYSCVRPCRYYAGtpsphKNPEKLDVIVYRENTEDIYMGIEweagdeigdklikh 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322097 155 -------------KTYIDKATGTRVadatKRISEIATRRIATIALDIALKRLQTRGQATLTvtHKSNVLSQSDGLFR--- 218
Cdd:PRK07362 181 lneevipaspelgKRQIPLGSGIGI----KPVSKTGSQRHIRRAIEHALRLPGDKRHVTLV--HKGNIMKYTEGAFRdwg 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322097 219 ----------------------------------------------------EICKEVYE---SNKDKYGQIKY------ 237
Cdd:PRK07362 255 yelattefrdecvtereswilsnkeknpnisiednarmiepgydsltpekkaAICAEVKEvldSIWSSHGNGKWkekvlv 334
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322097 238 NEQIVDSMVYRLFREPQCFDVIVAPNLYGDILSDGAAALVGSLGVVPSANVGPEIVIGEPCHGSAPDIAGKGIANPIATI 317
Cdd:PRK07362 335 DDRIADSIFQQIQTRPQEYSILATLNLNGDYISDAAAAIVGGLGMAPGANIGDNAAIFEATHGTAPKHAGLDRINPGSVI 414
|
410 420 430
....*....|....*....|....*....|....*..
gi 6322097 318 RSTALMLEFLGHNEAAQDIYKAVDANLREGSIkTPDL 354
Cdd:PRK07362 415 LSGVMMLEYLGWQEAADLITKGLSAAIANKQV-TYDL 450
|
|
| PLN00103 |
PLN00103 |
isocitrate dehydrogenase (NADP+); Provisional |
103-317 |
3.26e-07 |
|
isocitrate dehydrogenase (NADP+); Provisional
Pssm-ID: 177720 Cd Length: 410 Bit Score: 51.76 E-value: 3.26e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322097 103 VEGYSSPIVALRREMGlfANVRPVKSVEGEKGKpIDMVIVRENTEDlyiKIEKTYIDKATGTRVADATKRISEiATRRIA 182
Cdd:PLN00103 123 VPGWTKPICIGRHAFG--DQYRATDAVIKGPGK-LKLVFVPEGKDE---KTELEVYNFTGAGGVALSMYNTDE-SIRAFA 195
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322097 183 TIALDIALKRlqtrgQATLTVTHKSNVLSQSDGLFREICKEVYESN-KDKY--GQIKYNEQIVDSMV-YRLFREPQCfdV 258
Cdd:PLN00103 196 EASMNTAYQK-----KWPLYLSTKNTILKKYDGRFKDIFQEVYEAQwKSKFeaAGIWYEHRLIDDMVaYALKSEGGY--V 268
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 6322097 259 IVAPNLYGDILSDGAAALVGSLGVVPSANVGPE--IVIGEPCHGSAP------DIAGKGIANPIATI 317
Cdd:PLN00103 269 WACKNYDGDVQSDFLAQGFGSLGLMTSVLVCPDgkTIEAEAAHGTVTrhyrvhQKGGETSTNSIASI 335
|
|
| PLN03065 |
PLN03065 |
isocitrate dehydrogenase (NADP+); Provisional |
103-317 |
3.59e-07 |
|
isocitrate dehydrogenase (NADP+); Provisional
Pssm-ID: 178617 [Multi-domain] Cd Length: 483 Bit Score: 51.81 E-value: 3.59e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322097 103 VEGYSSPIVALRREMGlfANVRPVKSVEGEKGKpIDMVIVRENTEDLyIKIEkTYIDKATGtrVADATKRISEiATRRIA 182
Cdd:PLN03065 191 VPGWKKPICIGRHAFG--DQYRATDTVIKGPGK-LKMVFVPEDGNAP-VELD-VYDFKGPG--VALAMYNVDE-SIRAFA 262
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322097 183 TIALDIALKRlqtrgQATLTVTHKSNVLSQSDGLFREICKEVYESN-KDKYGQ--IKYNEQIVDSMVYRLFREPQCFdVI 259
Cdd:PLN03065 263 ESSMAMALQK-----KWPLYLSTKNTILKKYDGRFKDIFQEVYEEQwKQKFEEhsIWYEHRLIDDMVAYAVKSEGGY-VW 336
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 6322097 260 VAPNLYGDILSDGAAALVGSLGVVPSANVGPE--IVIGEPCHGSAP---DIAGKGI---ANPIATI 317
Cdd:PLN03065 337 ACKNYDGDVQSDLLAQGFGSLGLMTSVLLSSDgkTLEAEAAHGTVTrhfRLHQKGQetsTNSIASI 402
|
|
| PTZ00435 |
PTZ00435 |
isocitrate dehydrogenase; Provisional |
201-317 |
1.30e-06 |
|
isocitrate dehydrogenase; Provisional
Pssm-ID: 240417 Cd Length: 413 Bit Score: 49.99 E-value: 1.30e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322097 201 LTVTHKSNVLSQSDGLFREICKEVYESN-KDKYGQ--IKYNEQIVDSMVYRLFREPQCFdVIVAPNLYGDILSDGAAALV 277
Cdd:PTZ00435 208 LYLSTKNTILKKYDGRFKDIFQEIYDEEyKAKFEKagLWYEHRLIDDMVAQAIKSEGGF-VWACKNYDGDVQSDIVAQGY 286
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 6322097 278 GSLGVVPSANVGPE--IVIGEPCHGS------APDIAGKGIANPIATI 317
Cdd:PTZ00435 287 GSLGLMTSVLVCPDgkTVEAEAAHGTvtrhyrQHQKGKETSTNSIASI 334
|
|
| PRK08299 |
PRK08299 |
NADP-dependent isocitrate dehydrogenase; |
206-317 |
1.21e-04 |
|
NADP-dependent isocitrate dehydrogenase;
Pssm-ID: 236226 Cd Length: 402 Bit Score: 43.69 E-value: 1.21e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322097 206 KSNVLSQSDGLFREICKEVYESN-KDKYGQ--IKYNEQIVDSMVYRLFREPQCFdVIVAPNLYGDILSDGAAALVGSLGV 282
Cdd:PRK08299 210 KNTILKAYDGRFKDIFQEVYEAEfKEKFEAagITYEHRLIDDMVASALKWEGGY-VWACKNYDGDVQSDTVAQGFGSLGL 288
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 6322097 283 VPSANVGPE--IVIGEPCHGSAPD-----IAGKGIA-NPIATI 317
Cdd:PRK08299 289 MTSVLMTPDgkTVEAEAAHGTVTRhyrqhQKGEETStNPIASI 331
|
|
| |
