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Conserved domains on  [gi|6322351|ref|NP_012425|]
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Gzf3p [Saccharomyces cerevisiae S288C]

Protein Classification

GATA-type transcription factor( domain architecture ID 11475743)

GATA-type transcription factor binds to the DNA consensus sequence [AT]GATA[AG] and may function as a transcription factor/regulator

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
GAT1 COG5641
GATA Zn-finger-containing transcription factor [Transcription];
4-551 1.37e-85

GATA Zn-finger-containing transcription factor [Transcription];


:

Pssm-ID: 227928 [Multi-domain]  Cd Length: 498  Bit Score: 274.06  E-value: 1.37e-85
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322351    4 QATTLRGYNIRKRDNVFEPKSSENLNSLNQSEEEGHIGRW----PPLGYEAVSAEQKSAVQLRESQAGASISNNMNFKAN 79
Cdd:COG5641  25 DLHKHNLPNAAPNIEDNTNRSASIDQSLKDNPEHGDLTENmtpsLPSGNASISGSPRFVNRIQEHRASSRQSSISSLSDF 104
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322351   80 DKSFSTSTAGRMSPDTN----SLHHILPKNQVKNNGQTMDANCNNNVSNDANVP-VCKNCLTSTTPLWRRDEH-----GA 149
Cdd:COG5641 105 PISSSSSTSNAASPSTNytdeSNQQFSSYNTTLNPGGTSSLNPNNNQSDNSNQPhVCSNCKTTSTPLWRRASSesslpGN 184
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322351  150 MLCNACGLFLKLHGKPR-PISLKTDVIKSRN-RKSNTNHAHNLDNfrnqtliaelkgdCNIESSG-RKANRVT-SEDKKK 225
Cdd:COG5641 185 NLCNACGLYLKLHGSPRaPISLKSDSIKSRSsRSSHNNNDSNGEN-------------ANTESIGnSSASKLTkSWEERP 251
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322351  226 KSSQLLMGTSSTAKISKKPKteskersdshlsATKLEVLMSGDCSRPNLKPKlpkqdtaiyqeklLTFPSYTDVKEYSNS 305
Cdd:COG5641 252 QGRQLLSDAGSLSPRSNNPK------------SPLLEGLMGSTSLQPVSTPK-------------LVLPSDKKRSTLTTS 306
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322351  306 AhqsAFIKERSQFNAASFPLNASHSVTSKTGADSPQLPhlSMLLGSLSSTSISNNGSEIVSNcnngiastaATLAPTSSR 385
Cdd:COG5641 307 T---ATPLWRRTSDKSSFSCNASGSALKPPGSKRPLLP--KPDPNSKRSNATCMNCSSTPTN---------KILSPPTTS 372
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322351  386 TTDSNPSEVPNQIRSTMSSPDIISAKRndpaplsfhmasindmletrdraisnvktetTPPHFIPFLQSSKAPCISKANS 465
Cdd:COG5641 373 NSPGAQVKLPNQTRSTGATKKKITRRR-------------------------------MNSGKIPALSSSMKNPVPKEFS 421
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322351  466 QSISNSVSSSDVSGRKFenhpakdlgdQLSTKLHKEEEIIKLKTRINELELVTDLYRRHINELDGKCRALEE-RLQRTVK 544
Cdd:COG5641 422 PLIPQSTESETPSQSKS----------SLTSKLEEFESLSLLKSVSSMMNLENDLSSSHDSALFDKLDDSAGvKNSEIHN 491

                ....*..
gi 6322351  545 QEGNKGG 551
Cdd:COG5641 492 MNSDSCD 498
 
Name Accession Description Interval E-value
GAT1 COG5641
GATA Zn-finger-containing transcription factor [Transcription];
4-551 1.37e-85

GATA Zn-finger-containing transcription factor [Transcription];


Pssm-ID: 227928 [Multi-domain]  Cd Length: 498  Bit Score: 274.06  E-value: 1.37e-85
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322351    4 QATTLRGYNIRKRDNVFEPKSSENLNSLNQSEEEGHIGRW----PPLGYEAVSAEQKSAVQLRESQAGASISNNMNFKAN 79
Cdd:COG5641  25 DLHKHNLPNAAPNIEDNTNRSASIDQSLKDNPEHGDLTENmtpsLPSGNASISGSPRFVNRIQEHRASSRQSSISSLSDF 104
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322351   80 DKSFSTSTAGRMSPDTN----SLHHILPKNQVKNNGQTMDANCNNNVSNDANVP-VCKNCLTSTTPLWRRDEH-----GA 149
Cdd:COG5641 105 PISSSSSTSNAASPSTNytdeSNQQFSSYNTTLNPGGTSSLNPNNNQSDNSNQPhVCSNCKTTSTPLWRRASSesslpGN 184
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322351  150 MLCNACGLFLKLHGKPR-PISLKTDVIKSRN-RKSNTNHAHNLDNfrnqtliaelkgdCNIESSG-RKANRVT-SEDKKK 225
Cdd:COG5641 185 NLCNACGLYLKLHGSPRaPISLKSDSIKSRSsRSSHNNNDSNGEN-------------ANTESIGnSSASKLTkSWEERP 251
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322351  226 KSSQLLMGTSSTAKISKKPKteskersdshlsATKLEVLMSGDCSRPNLKPKlpkqdtaiyqeklLTFPSYTDVKEYSNS 305
Cdd:COG5641 252 QGRQLLSDAGSLSPRSNNPK------------SPLLEGLMGSTSLQPVSTPK-------------LVLPSDKKRSTLTTS 306
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322351  306 AhqsAFIKERSQFNAASFPLNASHSVTSKTGADSPQLPhlSMLLGSLSSTSISNNGSEIVSNcnngiastaATLAPTSSR 385
Cdd:COG5641 307 T---ATPLWRRTSDKSSFSCNASGSALKPPGSKRPLLP--KPDPNSKRSNATCMNCSSTPTN---------KILSPPTTS 372
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322351  386 TTDSNPSEVPNQIRSTMSSPDIISAKRndpaplsfhmasindmletrdraisnvktetTPPHFIPFLQSSKAPCISKANS 465
Cdd:COG5641 373 NSPGAQVKLPNQTRSTGATKKKITRRR-------------------------------MNSGKIPALSSSMKNPVPKEFS 421
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322351  466 QSISNSVSSSDVSGRKFenhpakdlgdQLSTKLHKEEEIIKLKTRINELELVTDLYRRHINELDGKCRALEE-RLQRTVK 544
Cdd:COG5641 422 PLIPQSTESETPSQSKS----------SLTSKLEEFESLSLLKSVSSMMNLENDLSSSHDSALFDKLDDSAGvKNSEIHN 491

                ....*..
gi 6322351  545 QEGNKGG 551
Cdd:COG5641 492 MNSDSCD 498
ZnF_GATA cd00202
Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] ...
130-181 5.37e-19

Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C


Pssm-ID: 238123 [Multi-domain]  Cd Length: 54  Bit Score: 80.49  E-value: 5.37e-19
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....
gi 6322351  130 VCKNCLTSTTPLWRRDEH-GAMLCNACGLFLKLHGKPRPISLKT-DVIKSRNRK 181
Cdd:cd00202   1 ACSNCGTTTTPLWRRGPSgGSTLCNACGLYWKKHGVMRPLSKRKkDQIKRRNRK 54
ZnF_GATA smart00401
zinc finger binding to DNA consensus sequence [AT]GATA[AG];
127-175 1.05e-15

zinc finger binding to DNA consensus sequence [AT]GATA[AG];


Pssm-ID: 214648 [Multi-domain]  Cd Length: 52  Bit Score: 71.30  E-value: 1.05e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 6322351     127 NVPVCKNCLTSTTPLWRRDEHGA-MLCNACGLFLKLHGKP-RPISLKTDVI 175
Cdd:smart00401   2 SGRSCSNCGTTETPLWRRGPSGNkTLCNACGLYYKKHGGLkRPLSLKKDGI 52
GATA pfam00320
GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This ...
131-165 2.70e-12

GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This domain binds to DNA. Two GATA zinc fingers are found in the GATA transcription factors. However there are several proteins which only contain a single copy of the domain.


Pssm-ID: 425605 [Multi-domain]  Cd Length: 36  Bit Score: 61.18  E-value: 2.70e-12
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 6322351    131 CKNCLTSTTPLWRRDEHGA-MLCNACGLFLKLHGKP 165
Cdd:pfam00320   1 CSNCGTTKTPLWRRGPNGNrTLCNACGLYYKKKGLK 36
 
Name Accession Description Interval E-value
GAT1 COG5641
GATA Zn-finger-containing transcription factor [Transcription];
4-551 1.37e-85

GATA Zn-finger-containing transcription factor [Transcription];


Pssm-ID: 227928 [Multi-domain]  Cd Length: 498  Bit Score: 274.06  E-value: 1.37e-85
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322351    4 QATTLRGYNIRKRDNVFEPKSSENLNSLNQSEEEGHIGRW----PPLGYEAVSAEQKSAVQLRESQAGASISNNMNFKAN 79
Cdd:COG5641  25 DLHKHNLPNAAPNIEDNTNRSASIDQSLKDNPEHGDLTENmtpsLPSGNASISGSPRFVNRIQEHRASSRQSSISSLSDF 104
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322351   80 DKSFSTSTAGRMSPDTN----SLHHILPKNQVKNNGQTMDANCNNNVSNDANVP-VCKNCLTSTTPLWRRDEH-----GA 149
Cdd:COG5641 105 PISSSSSTSNAASPSTNytdeSNQQFSSYNTTLNPGGTSSLNPNNNQSDNSNQPhVCSNCKTTSTPLWRRASSesslpGN 184
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322351  150 MLCNACGLFLKLHGKPR-PISLKTDVIKSRN-RKSNTNHAHNLDNfrnqtliaelkgdCNIESSG-RKANRVT-SEDKKK 225
Cdd:COG5641 185 NLCNACGLYLKLHGSPRaPISLKSDSIKSRSsRSSHNNNDSNGEN-------------ANTESIGnSSASKLTkSWEERP 251
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322351  226 KSSQLLMGTSSTAKISKKPKteskersdshlsATKLEVLMSGDCSRPNLKPKlpkqdtaiyqeklLTFPSYTDVKEYSNS 305
Cdd:COG5641 252 QGRQLLSDAGSLSPRSNNPK------------SPLLEGLMGSTSLQPVSTPK-------------LVLPSDKKRSTLTTS 306
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322351  306 AhqsAFIKERSQFNAASFPLNASHSVTSKTGADSPQLPhlSMLLGSLSSTSISNNGSEIVSNcnngiastaATLAPTSSR 385
Cdd:COG5641 307 T---ATPLWRRTSDKSSFSCNASGSALKPPGSKRPLLP--KPDPNSKRSNATCMNCSSTPTN---------KILSPPTTS 372
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322351  386 TTDSNPSEVPNQIRSTMSSPDIISAKRndpaplsfhmasindmletrdraisnvktetTPPHFIPFLQSSKAPCISKANS 465
Cdd:COG5641 373 NSPGAQVKLPNQTRSTGATKKKITRRR-------------------------------MNSGKIPALSSSMKNPVPKEFS 421
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322351  466 QSISNSVSSSDVSGRKFenhpakdlgdQLSTKLHKEEEIIKLKTRINELELVTDLYRRHINELDGKCRALEE-RLQRTVK 544
Cdd:COG5641 422 PLIPQSTESETPSQSKS----------SLTSKLEEFESLSLLKSVSSMMNLENDLSSSHDSALFDKLDDSAGvKNSEIHN 491

                ....*..
gi 6322351  545 QEGNKGG 551
Cdd:COG5641 492 MNSDSCD 498
ZnF_GATA cd00202
Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] ...
130-181 5.37e-19

Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C


Pssm-ID: 238123 [Multi-domain]  Cd Length: 54  Bit Score: 80.49  E-value: 5.37e-19
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....
gi 6322351  130 VCKNCLTSTTPLWRRDEH-GAMLCNACGLFLKLHGKPRPISLKT-DVIKSRNRK 181
Cdd:cd00202   1 ACSNCGTTTTPLWRRGPSgGSTLCNACGLYWKKHGVMRPLSKRKkDQIKRRNRK 54
ZnF_GATA smart00401
zinc finger binding to DNA consensus sequence [AT]GATA[AG];
127-175 1.05e-15

zinc finger binding to DNA consensus sequence [AT]GATA[AG];


Pssm-ID: 214648 [Multi-domain]  Cd Length: 52  Bit Score: 71.30  E-value: 1.05e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 6322351     127 NVPVCKNCLTSTTPLWRRDEHGA-MLCNACGLFLKLHGKP-RPISLKTDVI 175
Cdd:smart00401   2 SGRSCSNCGTTETPLWRRGPSGNkTLCNACGLYYKKHGGLkRPLSLKKDGI 52
GATA pfam00320
GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This ...
131-165 2.70e-12

GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This domain binds to DNA. Two GATA zinc fingers are found in the GATA transcription factors. However there are several proteins which only contain a single copy of the domain.


Pssm-ID: 425605 [Multi-domain]  Cd Length: 36  Bit Score: 61.18  E-value: 2.70e-12
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 6322351    131 CKNCLTSTTPLWRRDEHGA-MLCNACGLFLKLHGKP 165
Cdd:pfam00320   1 CSNCGTTKTPLWRRGPNGNrTLCNACGLYYKKKGLK 36
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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