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Conserved domains on  [gi|6322661|ref|NP_012734|]
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Fat3p [Saccharomyces cerevisiae S288C]

Protein Classification

SUR7/PalI family protein( domain architecture ID 581216)

SUR7/PalI family protein such as fungal Protein DCV1 (demands Cdc28 kinase activity for viability 1)

Gene Ontology:  GO:0005886

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SUR7 super family cl24030
SUR7/PalI family; This family consists of several fungal-specific SUR7 proteins. Its activity ...
 465-640 7.71e-04

SUR7/PalI family; This family consists of several fungal-specific SUR7 proteins. Its activity regulates expression of RVS161, a homolog of human endophilin, suggesting a function for both in endocytosis. The protein carries four transmembrane domains and is thus likely to act as an anchoring protein for the eisosome to the plasma membrane. Eisosomes are the immobile protein complexes, that include the proteins Pil1 and Lsp1, which co-localize with sites of protein and lipid endocytosis at the plasma membrane. SUR7 protein may play a role in sporulation. This family also includes PalI which is part of a pH signal transduction cascade. Based on the similarity of PalI to the yeast Rim9 meiotic signal transduction component it has been suggested that PalI might be a membrane sensor for ambient pH.


The actual alignment was detected with superfamily member pfam06687:

Pssm-ID: 420163  Cd Length: 201  Bit Score: 41.55  E-value: 7.71e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322661    465 PIYYRLSIFTLChANLENKILDCNSPHAVQNLDFRSIIydalvtsdfqpylnalNISANDLyLEGKLLHREHQYVPAVRS 544
Cdd:pfam06687  47 PDFYRWGVWGYC-GNSDNNNTNCSKPSAGYPFDPLDNF----------------GTNSNGK-LPSSFRDTLSTYYYLSRF 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322661    545 VLALNLLAIIFSFFTMIFIILLYFN--RYMFKQPLWLIALALhVCVGVATVLAAIIISVMIAIIKSgtaddkYGVVFKAG 622
Cdd:pfam06687 109 MFIVHIIALFFTVIALILGLLAIFShsRRGLLVNLLLSFLAF-LFTLLAALLDTALFVKARNAFKD------YGISASLG 181

                         170
                  ....*....|....*...
gi 6322661    623 PAYTGLIWTAFALSFIAT 640
Cdd:pfam06687 182 VKWFAFLWLAVAAALLSL 199
 
Name Accession Description Interval E-value
SUR7 pfam06687
SUR7/PalI family; This family consists of several fungal-specific SUR7 proteins. Its activity ...
 465-640 7.71e-04

SUR7/PalI family; This family consists of several fungal-specific SUR7 proteins. Its activity regulates expression of RVS161, a homolog of human endophilin, suggesting a function for both in endocytosis. The protein carries four transmembrane domains and is thus likely to act as an anchoring protein for the eisosome to the plasma membrane. Eisosomes are the immobile protein complexes, that include the proteins Pil1 and Lsp1, which co-localize with sites of protein and lipid endocytosis at the plasma membrane. SUR7 protein may play a role in sporulation. This family also includes PalI which is part of a pH signal transduction cascade. Based on the similarity of PalI to the yeast Rim9 meiotic signal transduction component it has been suggested that PalI might be a membrane sensor for ambient pH.


Pssm-ID: 399580  Cd Length: 201  Bit Score: 41.55  E-value: 7.71e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322661    465 PIYYRLSIFTLChANLENKILDCNSPHAVQNLDFRSIIydalvtsdfqpylnalNISANDLyLEGKLLHREHQYVPAVRS 544
Cdd:pfam06687  47 PDFYRWGVWGYC-GNSDNNNTNCSKPSAGYPFDPLDNF----------------GTNSNGK-LPSSFRDTLSTYYYLSRF 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322661    545 VLALNLLAIIFSFFTMIFIILLYFN--RYMFKQPLWLIALALhVCVGVATVLAAIIISVMIAIIKSgtaddkYGVVFKAG 622
Cdd:pfam06687 109 MFIVHIIALFFTVIALILGLLAIFShsRRGLLVNLLLSFLAF-LFTLLAALLDTALFVKARNAFKD------YGISASLG 181

                         170
                  ....*....|....*...
gi 6322661    623 PAYTGLIWTAFALSFIAT 640
Cdd:pfam06687 182 VKWFAFLWLAVAAALLSL 199
 
Name Accession Description Interval E-value
SUR7 pfam06687
SUR7/PalI family; This family consists of several fungal-specific SUR7 proteins. Its activity ...
 465-640 7.71e-04

SUR7/PalI family; This family consists of several fungal-specific SUR7 proteins. Its activity regulates expression of RVS161, a homolog of human endophilin, suggesting a function for both in endocytosis. The protein carries four transmembrane domains and is thus likely to act as an anchoring protein for the eisosome to the plasma membrane. Eisosomes are the immobile protein complexes, that include the proteins Pil1 and Lsp1, which co-localize with sites of protein and lipid endocytosis at the plasma membrane. SUR7 protein may play a role in sporulation. This family also includes PalI which is part of a pH signal transduction cascade. Based on the similarity of PalI to the yeast Rim9 meiotic signal transduction component it has been suggested that PalI might be a membrane sensor for ambient pH.


Pssm-ID: 399580  Cd Length: 201  Bit Score: 41.55  E-value: 7.71e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322661    465 PIYYRLSIFTLChANLENKILDCNSPHAVQNLDFRSIIydalvtsdfqpylnalNISANDLyLEGKLLHREHQYVPAVRS 544
Cdd:pfam06687  47 PDFYRWGVWGYC-GNSDNNNTNCSKPSAGYPFDPLDNF----------------GTNSNGK-LPSSFRDTLSTYYYLSRF 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322661    545 VLALNLLAIIFSFFTMIFIILLYFN--RYMFKQPLWLIALALhVCVGVATVLAAIIISVMIAIIKSgtaddkYGVVFKAG 622
Cdd:pfam06687 109 MFIVHIIALFFTVIALILGLLAIFShsRRGLLVNLLLSFLAF-LFTLLAALLDTALFVKARNAFKD------YGISASLG 181

                         170
                  ....*....|....*...
gi 6322661    623 PAYTGLIWTAFALSFIAT 640
Cdd:pfam06687 182 VKWFAFLWLAVAAALLSL 199
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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