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Conserved domains on  [gi|398364671|ref|NP_012901|]
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bifunctional uridylate/adenylate kinase [Saccharomyces cerevisiae S288C]

Protein Classification

nucleoside monophosphate kinase( domain architecture ID 1005013)

nucleoside monophosphate kinase catalyzes the transfer of the terminal phosphoryl group from a nucleoside triphosphate, usually ATP, to a nucleoside monophosphate

CATH:  3.40.50.300
EC:  2.7.4.-
Gene Ontology:  GO:0050145|GO:0005524

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
UMP_CMP_kin_fam super family cl29285
UMP-CMP kinase family; This subfamily of the adenylate kinase superfamily contains examples of ...
 18-196 7.36e-91

UMP-CMP kinase family; This subfamily of the adenylate kinase superfamily contains examples of UMP-CMP kinase, as well as others proteins with unknown specificity, some currently designated adenylate kinase. All known members are eukaryotic.


The actual alignment was detected with superfamily member TIGR01359:

Pssm-ID: 273576 [Multi-domain]  Cd Length: 185  Bit Score: 263.85  E-value: 7.36e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364671   18 VIFVLGGPGAGKGTQCEKLVKDYSFVHLSAGDLLRAEQGRAGSQYGELIKNCIKEGQIVPQEITLALLRNAISDNVKANk 97
Cdd:TIGR01359   1 VVFVLGGPGSGKGTQCAKIVENFGFTHLSAGDLLRAEIKREGSENGSLIESYIKEGKIVPSEVTVELLKKAIQEDGSSK- 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364671   98 hKFLIDGFPRKMDQAISFERDI---VESKFILFFDCPEDIMLERLLERGKTSGRSDDNIESIKKRFNTFKETSMPVIEYF 174
Cdd:TIGR01359  80 -KFLIDGFPRNEENLEAWEKLMdnkVNFKFVLFFDCPEETMIKRLLKRGQTSGRVDDNIETLKKRFRTYNEETLPIIEHF 158

                         170       180
                  ....*....|....*....|..
gi 398364671  175 ETKSKVVRVRCDRSVEDVYKDV 196
Cdd:TIGR01359 159 ENKGKVKEINAEGSVEEVFEDV 180
 
Name Accession Description Interval E-value
UMP_CMP_kin_fam TIGR01359
UMP-CMP kinase family; This subfamily of the adenylate kinase superfamily contains examples of ...
 18-196 7.36e-91

UMP-CMP kinase family; This subfamily of the adenylate kinase superfamily contains examples of UMP-CMP kinase, as well as others proteins with unknown specificity, some currently designated adenylate kinase. All known members are eukaryotic.


Pssm-ID: 273576 [Multi-domain]  Cd Length: 185  Bit Score: 263.85  E-value: 7.36e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364671   18 VIFVLGGPGAGKGTQCEKLVKDYSFVHLSAGDLLRAEQGRAGSQYGELIKNCIKEGQIVPQEITLALLRNAISDNVKANk 97
Cdd:TIGR01359   1 VVFVLGGPGSGKGTQCAKIVENFGFTHLSAGDLLRAEIKREGSENGSLIESYIKEGKIVPSEVTVELLKKAIQEDGSSK- 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364671   98 hKFLIDGFPRKMDQAISFERDI---VESKFILFFDCPEDIMLERLLERGKTSGRSDDNIESIKKRFNTFKETSMPVIEYF 174
Cdd:TIGR01359  80 -KFLIDGFPRNEENLEAWEKLMdnkVNFKFVLFFDCPEETMIKRLLKRGQTSGRVDDNIETLKKRFRTYNEETLPIIEHF 158

                         170       180
                  ....*....|....*....|..
gi 398364671  175 ETKSKVVRVRCDRSVEDVYKDV 196
Cdd:TIGR01359 159 ENKGKVKEINAEGSVEEVFEDV 180
ADK pfam00406
Adenylate kinase;
21-177 1.27e-71

Adenylate kinase;


Pssm-ID: 395329 [Multi-domain]  Cd Length: 184  Bit Score: 215.25  E-value: 1.27e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364671   21 VLGGPGAGKGTQCEKLVKDYSFVHLSAGDLLRAEQgRAGSQYGELIKNCIKEGQIVPQEITLALLRNAISDNvkANKHKF 100
Cdd:pfam00406   1 LLGPPGAGKGTQAEKIVQKYGLPHLSTGDLLRAEI-KSGTELGKEAKEYMDKGELVPDEVVVGLVKERLEQN--DCKNGF 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364671  101 LIDGFPRKMDQAISFER---DIVESKFILFFDCPEDIMLERLLERGKT---------------------------SGRSD 150
Cdd:pfam00406  78 LLDGFPRTVPQAEALEElleRGIKLDYVIEFDVPDEVLVERLTGRRIHpnsgrsyhlefnppkvpgkddvtgeplVQRSD 157

                         170       180
                  ....*....|....*....|....*..
gi 398364671  151 DNIESIKKRFNTFKETSMPVIEYFETK 177
Cdd:pfam00406 158 DNEETVKKRLETYHKQTKPLIDYYKKK 184
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 18-192 4.99e-68

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 206.32  E-value: 4.99e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364671  18 VIFVLGGPGAGKGTQCEKLVKDYSFVHLSAGDLLRAEQgRAGSQYGELIKNCIKEGQIVPQEITLALLRNAISDNVKANk 97
Cdd:cd01428    1 RILLLGPPGSGKGTQAERLAKKYGLPHISTGDLLREEI-ASGTELGKKAKEYIDSGKLVPDEIVIKLLKERLKKPDCKK- 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364671  98 hKFLIDGFPRKMDQAISFERDIVESK---FILFFDCPEDIMLERLLERGKT-------------------SGRSDDNIES 155
Cdd:cd01428   79 -GFILDGFPRTVDQAEALDELLDEGIkpdKVIELDVPDEVLIERILGRRICpvsgrvyhlgkddvtgeplSQRSDDNEET 157

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 398364671 156 IKKRFNTFKETSMPVIEYFETKSKVVRVRCDRSVEDV 192
Cdd:cd01428  158 IKKRLEVYKEQTAPLIDYYKKKGKLVEIDGSGDIDEV 194
PLN02200 PLN02200
adenylate kinase family protein
 18-197 3.86e-54

adenylate kinase family protein


Pssm-ID: 215125 [Multi-domain]  Cd Length: 234  Bit Score: 172.38  E-value: 3.86e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364671  18 VIFVLGGPGAGKGTQCEKLVKDYSFVHLSAGDLLRAEQgRAGSQYGELIKNCIKEGQIVPQEITLALLRNAI--SDNvka 95
Cdd:PLN02200  45 ITFVLGGPGSGKGTQCEKIVETFGFKHLSAGDLLRREI-ASNSEHGAMILNTIKEGKIVPSEVTVKLIQKEMesSDN--- 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364671  96 nkHKFLIDGFPRKMDQAISFERDI-VESKFILFFDCPEDIMLERLLERGKtsGRSDDNIESIKKRFNTFKETSMPVIEYF 174
Cdd:PLN02200 121 --NKFLIDGFPRTEENRIAFERIIgAEPNVVLFFDCPEEEMVKRVLNRNQ--GRVDDNIDTIKKRLKVFNALNLPVIDYY 196

                        170       180
                 ....*....|....*....|...
gi 398364671 175 ETKSKVVRVRCDRSVEDVYKDVQ 197
Cdd:PLN02200 197 SKKGKLYTINAVGTVDEIFEQVR 219
Adk COG0563
Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or ...
 18-200 4.26e-51

Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or related kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440329 [Multi-domain]  Cd Length: 212  Bit Score: 163.76  E-value: 4.26e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364671  18 VIFvLGGPGAGKGTQCEKLVKDYSFVHLSAGDLLRAEQgRAGSQYGELIKNCIKEGQIVPQEITLALLRNAISDNVKANK 97
Cdd:COG0563    3 IIL-LGPPGAGKGTQAKRLAEKYGIPHISTGDMLRAAV-KAGTELGKKAKEYMDAGELVPDEIVIGLVKERLAQPDCANG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364671  98 hkFLIDGFPRKMDQAISFERDIVESK----FILFFDCPEDIMLERLLER---------------------------GKTS 146
Cdd:COG0563   81 --FILDGFPRTVAQAEALDELLAELGikldAVIELDVDDEELVERLSGRrvcpncgatyhvkfnppkvegvcdkcgGELV 158

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 398364671 147 GRSDDNIESIKKRFNTFKETSMPVIEYFETKSKVVRVRCDRSVEDVYKDVQDAI 200
Cdd:COG0563  159 QRADDNEETVRKRLEVYHEQTAPLIDYYRKKGKLVEIDGEGSIEEVTADILAIL 212
 
Name Accession Description Interval E-value
UMP_CMP_kin_fam TIGR01359
UMP-CMP kinase family; This subfamily of the adenylate kinase superfamily contains examples of ...
 18-196 7.36e-91

UMP-CMP kinase family; This subfamily of the adenylate kinase superfamily contains examples of UMP-CMP kinase, as well as others proteins with unknown specificity, some currently designated adenylate kinase. All known members are eukaryotic.


Pssm-ID: 273576 [Multi-domain]  Cd Length: 185  Bit Score: 263.85  E-value: 7.36e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364671   18 VIFVLGGPGAGKGTQCEKLVKDYSFVHLSAGDLLRAEQGRAGSQYGELIKNCIKEGQIVPQEITLALLRNAISDNVKANk 97
Cdd:TIGR01359   1 VVFVLGGPGSGKGTQCAKIVENFGFTHLSAGDLLRAEIKREGSENGSLIESYIKEGKIVPSEVTVELLKKAIQEDGSSK- 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364671   98 hKFLIDGFPRKMDQAISFERDI---VESKFILFFDCPEDIMLERLLERGKTSGRSDDNIESIKKRFNTFKETSMPVIEYF 174
Cdd:TIGR01359  80 -KFLIDGFPRNEENLEAWEKLMdnkVNFKFVLFFDCPEETMIKRLLKRGQTSGRVDDNIETLKKRFRTYNEETLPIIEHF 158

                         170       180
                  ....*....|....*....|..
gi 398364671  175 ETKSKVVRVRCDRSVEDVYKDV 196
Cdd:TIGR01359 159 ENKGKVKEINAEGSVEEVFEDV 180
ADK pfam00406
Adenylate kinase;
21-177 1.27e-71

Adenylate kinase;


Pssm-ID: 395329 [Multi-domain]  Cd Length: 184  Bit Score: 215.25  E-value: 1.27e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364671   21 VLGGPGAGKGTQCEKLVKDYSFVHLSAGDLLRAEQgRAGSQYGELIKNCIKEGQIVPQEITLALLRNAISDNvkANKHKF 100
Cdd:pfam00406   1 LLGPPGAGKGTQAEKIVQKYGLPHLSTGDLLRAEI-KSGTELGKEAKEYMDKGELVPDEVVVGLVKERLEQN--DCKNGF 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364671  101 LIDGFPRKMDQAISFER---DIVESKFILFFDCPEDIMLERLLERGKT---------------------------SGRSD 150
Cdd:pfam00406  78 LLDGFPRTVPQAEALEElleRGIKLDYVIEFDVPDEVLVERLTGRRIHpnsgrsyhlefnppkvpgkddvtgeplVQRSD 157

                         170       180
                  ....*....|....*....|....*..
gi 398364671  151 DNIESIKKRFNTFKETSMPVIEYFETK 177
Cdd:pfam00406 158 DNEETVKKRLETYHKQTKPLIDYYKKK 184
aden_kin_iso1 TIGR01360
adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. ...
 16-204 7.50e-71

adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. This clade is found only in eukaryotes and includes human adenylate kinase isozyme 1 (myokinase). Within the adenylate kinase superfamily, this set appears specifically closely related to a subfamily of eukaryotic UMP-CMP kinases (TIGR01359), rather than to the large clade of bacterial, archaeal, and eukaryotic adenylate kinase family members in TIGR01351.


Pssm-ID: 130427 [Multi-domain]  Cd Length: 188  Bit Score: 213.52  E-value: 7.50e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364671   16 VSVIFVLGGPGAGKGTQCEKLVKDYSFVHLSAGDLLRAEQgRAGSQYGELIKNCIKEGQIVPQEITLALLRNAISDNVKA 95
Cdd:TIGR01360   3 CKIIFIVGGPGSGKGTQCEKIVEKYGFTHLSTGDLLRAEV-ASGSERGKQLQAIMESGDLVPLDTVLDLLKDAMVAALGT 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364671   96 NKhKFLIDGFPRKMDQAISFERDIVESKFILFFDCPEDIMLERLLERGKTSGRSDDNIESIKKRFNTFKETSMPVIEYFE 175
Cdd:TIGR01360  82 SK-GFLIDGYPREVKQGEEFERRIGPPTLVLYFDCSEDTMVKRLLKRAETSGRVDDNEKTIKKRLETYYKATEPVIAYYE 160

                         170       180
                  ....*....|....*....|....*....
gi 398364671  176 TKSKVVRVRCDRSVEDVYKDVQDAIrDSL 204
Cdd:TIGR01360 161 TKGKLRKINAEGTVDDVFLQVCTAI-DKL 188
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 18-192 4.99e-68

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 206.32  E-value: 4.99e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364671  18 VIFVLGGPGAGKGTQCEKLVKDYSFVHLSAGDLLRAEQgRAGSQYGELIKNCIKEGQIVPQEITLALLRNAISDNVKANk 97
Cdd:cd01428    1 RILLLGPPGSGKGTQAERLAKKYGLPHISTGDLLREEI-ASGTELGKKAKEYIDSGKLVPDEIVIKLLKERLKKPDCKK- 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364671  98 hKFLIDGFPRKMDQAISFERDIVESK---FILFFDCPEDIMLERLLERGKT-------------------SGRSDDNIES 155
Cdd:cd01428   79 -GFILDGFPRTVDQAEALDELLDEGIkpdKVIELDVPDEVLIERILGRRICpvsgrvyhlgkddvtgeplSQRSDDNEET 157

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 398364671 156 IKKRFNTFKETSMPVIEYFETKSKVVRVRCDRSVEDV 192
Cdd:cd01428  158 IKKRLEVYKEQTAPLIDYYKKKGKLVEIDGSGDIDEV 194
PLN02200 PLN02200
adenylate kinase family protein
 18-197 3.86e-54

adenylate kinase family protein


Pssm-ID: 215125 [Multi-domain]  Cd Length: 234  Bit Score: 172.38  E-value: 3.86e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364671  18 VIFVLGGPGAGKGTQCEKLVKDYSFVHLSAGDLLRAEQgRAGSQYGELIKNCIKEGQIVPQEITLALLRNAI--SDNvka 95
Cdd:PLN02200  45 ITFVLGGPGSGKGTQCEKIVETFGFKHLSAGDLLRREI-ASNSEHGAMILNTIKEGKIVPSEVTVKLIQKEMesSDN--- 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364671  96 nkHKFLIDGFPRKMDQAISFERDI-VESKFILFFDCPEDIMLERLLERGKtsGRSDDNIESIKKRFNTFKETSMPVIEYF 174
Cdd:PLN02200 121 --NKFLIDGFPRTEENRIAFERIIgAEPNVVLFFDCPEEEMVKRVLNRNQ--GRVDDNIDTIKKRLKVFNALNLPVIDYY 196

                        170       180
                 ....*....|....*....|...
gi 398364671 175 ETKSKVVRVRCDRSVEDVYKDVQ 197
Cdd:PLN02200 197 SKKGKLYTINAVGTVDEIFEQVR 219
Adk COG0563
Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or ...
 18-200 4.26e-51

Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or related kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440329 [Multi-domain]  Cd Length: 212  Bit Score: 163.76  E-value: 4.26e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364671  18 VIFvLGGPGAGKGTQCEKLVKDYSFVHLSAGDLLRAEQgRAGSQYGELIKNCIKEGQIVPQEITLALLRNAISDNVKANK 97
Cdd:COG0563    3 IIL-LGPPGAGKGTQAKRLAEKYGIPHISTGDMLRAAV-KAGTELGKKAKEYMDAGELVPDEIVIGLVKERLAQPDCANG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364671  98 hkFLIDGFPRKMDQAISFERDIVESK----FILFFDCPEDIMLERLLER---------------------------GKTS 146
Cdd:COG0563   81 --FILDGFPRTVAQAEALDELLAELGikldAVIELDVDDEELVERLSGRrvcpncgatyhvkfnppkvegvcdkcgGELV 158

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 398364671 147 GRSDDNIESIKKRFNTFKETSMPVIEYFETKSKVVRVRCDRSVEDVYKDVQDAI 200
Cdd:COG0563  159 QRADDNEETVRKRLEVYHEQTAPLIDYYRKKGKLVEIDGEGSIEEVTADILAIL 212
adk TIGR01351
adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ...
 18-201 1.45e-48

adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ATP as a phosphate donor for AMP. Most members of this family are known or believed to be adenylate kinase. However, some members accept other nucleotide triphosphates as donors, may be unable to use ATP, and may fail to complement adenylate kinase mutants. An example of a nucleoside-triphosphate--adenylate kinase (EC 2.7.4.10) is SP|Q9UIJ7, a GTP:AMP phosphotransferase. This family is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Nucleotide and nucleoside interconversions]


Pssm-ID: 273569 [Multi-domain]  Cd Length: 210  Bit Score: 157.40  E-value: 1.45e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364671   18 VIFvLGGPGAGKGTQCEKLVKDYSFVHLSAGDLLRAEQgRAGSQYGELIKNCIKEGQIVPQEITLALLRNAISDNvKANK 97
Cdd:TIGR01351   2 LVL-LGPPGSGKGTQAKRIAEKYGLPHISTGDLLRAEI-KAGTPLGKKAKEYMEKGELVPDEIVNQLVKERLTQN-DDNE 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364671   98 HKFLIDGFPRKMDQAISFErDIVESKF--ILFFDCPEDIMLERLLERG--KTSG-------------------------R 148
Cdd:TIGR01351  79 NGFILDGFPRTLSQAEALD-ALLEEPIdaVIELDVPDEELVERLSGRRicPSCGrvyhlkfnppkvpgcddctgellvqR 157

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 398364671  149 SDDNIESIKKRFNTFKETSMPVIEYFETKSKVVRVRCDRSVEDVYKDVQDAIR 201
Cdd:TIGR01351 158 EDDTEEVVKKRLEVYKEQTEPLIDYYKKRGILVQIDGNGPIDEVWKRILEALK 210
adk PRK00279
adenylate kinase; Reviewed
 22-200 7.35e-44

adenylate kinase; Reviewed


Pssm-ID: 234711 [Multi-domain]  Cd Length: 215  Bit Score: 145.68  E-value: 7.35e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364671  22 LGGPGAGKGTQCEKLVKDYSFVHLSAGDLLRAEQgRAGSQYGELIKNCIKEGQIVPQEITLALLRNAISDNVKANkhKFL 101
Cdd:PRK00279   6 LGPPGAGKGTQAKFIAEKYGIPHISTGDMLRAAV-KAGTELGKEAKSYMDAGELVPDEIVIGLVKERLAQPDCKN--GFL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364671 102 IDGFPRKMDQAISFERDIVESK----FILFFDCPEDIMLERLLER------GKT---------------------SGRSD 150
Cdd:PRK00279  83 LDGFPRTIPQAEALDEMLKELGikldAVIEIDVPDEELVERLSGRricpacGRTyhvkfnppkvegkcdvcgeelIQRAD 162

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 398364671 151 DNIESIKKRFNTFKETSMPVIEYFETKSKVVRVRCDRSVEDVYKDVQDAI 200
Cdd:PRK00279 163 DNEETVRKRLEVYHKQTAPLIDYYKKKGKLKKIDGTGSIDEVFADILKAL 212
PRK14527 PRK14527
adenylate kinase; Provisional
 18-201 6.16e-40

adenylate kinase; Provisional


Pssm-ID: 237745 [Multi-domain]  Cd Length: 191  Bit Score: 134.92  E-value: 6.16e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364671  18 VIFvLGGPGAGKGTQCEKLVKDYSFVHLSAGDLLRAEQGRaGSQYGELIKNCIKEGQIVPQEITLALLRNAISDnvkANK 97
Cdd:PRK14527   9 VIF-LGPPGAGKGTQAERLAQELGLKKLSTGDILRDHVAR-GTELGQRAKPIMEAGDLVPDELILALIRDELAG---MEP 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364671  98 HKFLIDGFPRKMDQAISFERDIVESKF----ILFFDCPEDIMLERLLERGKTSGRSDDNIESIKKRFNTFKETSMPVIEY 173
Cdd:PRK14527  84 VRVIFDGFPRTLAQAEALDRLLEELGArllaVVLLEVPDEELIRRIVERARQEGRSDDNEETVRRRQQVYREQTQPLVDY 163

                        170       180
                 ....*....|....*....|....*...
gi 398364671 174 FETKSKVVRVRCDRSVEDVYKDVQDAIR 201
Cdd:PRK14527 164 YEARGHLKRVDGLGTPDEVYARILKALG 191
AAA_17 pfam13207
AAA domain;
22-157 1.56e-38

AAA domain;


Pssm-ID: 463810 [Multi-domain]  Cd Length: 136  Bit Score: 129.28  E-value: 1.56e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364671   22 LGGPGAGKGTQCEKLVKDYSFVHLSAGDLLRAEQGRAGsqyGELIKNCIKEGQIVPQEITLALLRNAISDnvKANKHKFL 101
Cdd:pfam13207   1 TGVPGSGKTTQLKKLAEKLGFPHISAGDLLREEAKERG---LVEDRDEMRKLPLEPQKELQKLAAERIAE--EAGEGGVI 75

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 398364671  102 IDGFPRKMDQA---ISFERDIVES---KFILFFDCPEDIMLERLLERgKTSGRSDDNIESIK 157
Cdd:pfam13207  76 VDGHPRIKTPAgylPGLPVEVLRElkpDAIILLEADPEEILERRLKD-RTRGRDDDSEEEIR 136
PRK14531 PRK14531
adenylate kinase; Provisional
 22-200 3.92e-33

adenylate kinase; Provisional


Pssm-ID: 172997 [Multi-domain]  Cd Length: 183  Bit Score: 117.22  E-value: 3.92e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364671  22 LGGPGAGKGTQCEKLVKDYSFVHLSAGDLLRAEQGrAGSQYGELIKNCIKEGQIVPQEITLALLRNAISdnvKANKHKFL 101
Cdd:PRK14531   8 LGPPGAGKGTQAARLCAAHGLRHLSTGDLLRSEVA-AGSALGQEAEAVMNRGELVSDALVLAIVESQLK---ALNSGGWL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364671 102 IDGFPRKMDQAISFERDIVESK----FILFFDCPEDIMLERLLERgktsGRSDDNIESIKKRFNTFKETSMPVIEYFETK 177
Cdd:PRK14531  84 LDGFPRTVAQAEALEPLLEELKqpieAVVLLELDDAVLIERLLAR----GRADDNEAVIRNRLEVYREKTAPLIDHYRQR 159

                        170       180
                 ....*....|....*....|...
gi 398364671 178 SKVVRVRCDRSVEDVYKDVQDAI 200
Cdd:PRK14531 160 GLLQSVEAQGSIEAITERIEKVL 182
adk PRK02496
adenylate kinase; Provisional
 18-202 4.12e-33

adenylate kinase; Provisional


Pssm-ID: 179433 [Multi-domain]  Cd Length: 184  Bit Score: 117.16  E-value: 4.12e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364671  18 VIFvLGGPGAGKGTQCEKLVKDYSFVHLSAGDLLRAEQgRAGSQYGELIKNCIKEGQIVPQEITLALLRNAIsdNVKANK 97
Cdd:PRK02496   4 LIF-LGPPGAGKGTQAVVLAEHLHIPHISTGDILRQAI-KEQTPLGIKAQGYMDKGELVPDQLVLDLVQERL--QQPDAA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364671  98 HKFLIDGFPRKMDQAISFERDIVE----SKFILFFDCPEDIMLERLLERgktsGRSDDNIESIKKRFNTFKETSMPVIEY 173
Cdd:PRK02496  80 NGWILDGFPRKVTQAAFLDELLQEigqsGERVVNLDVPDDVVVERLLAR----GRKDDTEEVIRRRLEVYREQTAPLIDY 155

                        170       180
                 ....*....|....*....|....*....
gi 398364671 174 FETKSKVVRVRCDRSVEDVYKDVQDAIRD 202
Cdd:PRK02496 156 YRDRQKLLTIDGNQSVEAVTTELKAALAP 184
PRK14530 PRK14530
adenylate kinase; Provisional
 19-204 7.10e-31

adenylate kinase; Provisional


Pssm-ID: 237747 [Multi-domain]  Cd Length: 215  Bit Score: 112.19  E-value: 7.10e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364671  19 IFVLGGPGAGKGTQCEKLVKDYSFVHLSAGDLLRAEQGRAGS----QYGElIKNCIKEGQIVPQEITLALLRNAISDnvk 94
Cdd:PRK14530   6 ILLLGAPGAGKGTQSSNLAEEFGVEHVTTGDALRANKQMDISdmdtEYDT-PGEYMDAGELVPDAVVNEIVEEALSD--- 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364671  95 anKHKFLIDGFPRKMDQAISFErDIVESKFILFFDCPEDIMLERLLER---------------------------GKTSG 147
Cdd:PRK14530  82 --ADGFVLDGYPRNLEQAEYLE-SITDLDVVLYLDVSEEELVDRLTGRrvcpdcganyhvefnqpeeegvcdecgGELIQ 158

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 398364671 148 RSDDNIESIKKRFNTFKETSMPVIEYFETKSKVVRVRCDRSVEDVYKDVQDAIRDSL 204
Cdd:PRK14530 159 RDDDTEETVRERLDVFEENTEPVIEHYRDQGVLVEVDGEQTPDEVWADIQDAIDDAT 215
PRK14532 PRK14532
adenylate kinase; Provisional
 19-200 7.82e-30

adenylate kinase; Provisional


Pssm-ID: 184729 [Multi-domain]  Cd Length: 188  Bit Score: 108.76  E-value: 7.82e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364671  19 IFVLGGPGAGKGTQCEKLVKDYSFVHLSAGDLLRAEQGrAGSQYGELIKNCIKEGQIVPQEITLALLRNAISDNVKANKh 98
Cdd:PRK14532   3 LILFGPPAAGKGTQAKRLVEERGMVQLSTGDMLRAAIA-SGSELGQRVKGIMDRGELVSDEIVIALIEERLPEAEAAGG- 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364671  99 kFLIDGFPRKMDQAISFERDI------VESKFILFFDCPEdiMLERLLERGKTSGRSDDNIESIKKRFNTFKETSMPVIE 172
Cdd:PRK14532  81 -AIFDGFPRTVAQAEALDKMLasrgqkIDVVIRLKVDDEA--LIERIVKRFEEQGRPDDNPEVFVTRLDAYNAQTAPLLP 157

                        170       180
                 ....*....|....*....|....*...
gi 398364671 173 YFETKSKVVRVRCDRSVEDVYKDVQDAI 200
Cdd:PRK14532 158 YYAGQGKLTEVDGMGSIEAVAASIDAAL 185
PLN02842 PLN02842
nucleotide kinase
 23-197 1.80e-29

nucleotide kinase


Pssm-ID: 178435 [Multi-domain]  Cd Length: 505  Bit Score: 113.80  E-value: 1.80e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364671  23 GGPGAGKGTQCEKLVKDYSFVHLSAGDLLRAEQGrAGSQYGELIKNCIKEGQIVPQEITLALLRNAISDNvKANKHKFLI 102
Cdd:PLN02842   4 GAPASGKGTQCELIVHKFGLVHISTGDLLRAEVS-AGTDIGKRAKEFMNSGRLVPDEIVIAMVTGRLSRE-DAKEKGWLL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364671 103 DGFPRKMDQAISFERDIVESKFILFFDCPEDIMLERLLER------GKTS-----------------GRSDDNIESIKKR 159
Cdd:PLN02842  82 DGYPRSFAQAQSLEKLKIRPDIFILLDVPDEILIDRCVGRrldpvtGKIYhiknfppeseeikarliTRPDDTEEKVKAR 161

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 398364671 160 FNTFKETSMPVIEYFEtkSKVVRVRCDRSVEDVYKDVQ 197
Cdd:PLN02842 162 LQIYKKNAEAILSTYS--DIMVKIDGNRPKEVVFEEIS 197
PRK14528 PRK14528
adenylate kinase; Provisional
 19-200 1.20e-28

adenylate kinase; Provisional


Pssm-ID: 172994 [Multi-domain]  Cd Length: 186  Bit Score: 105.86  E-value: 1.20e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364671  19 IFVLGGPGAGKGTQCEKLVKDYSFVHLSAGDLLRAEQgRAGSQYGELIKNCIKEGQIVPQEITLALLRNAISDNVKANKh 98
Cdd:PRK14528   4 IIFMGPPGAGKGTQAKILCERLSIPQISTGDILREAV-KNQTAMGIEAKRYMDAGDLVPDSVVIGIIKDRIREADCKNG- 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364671  99 kFLIDGFPRKMDQAISFERDIVESKF----ILFFDCPEDIMLERLLERGKTSGRSDDNIESIKKRFNTFKETSMPVIEYF 174
Cdd:PRK14528  82 -FLLDGFPRTVEQADALDALLKNEGKsidkAINLEVPDGELLKRLLGRAEIEGRADDNEATIKNRLDNYNKKTLPLLDFY 160

                        170       180
                 ....*....|....*....|....*.
gi 398364671 175 ETKSKVVRVRCDRSVEDVYKDVQDAI 200
Cdd:PRK14528 161 AAQKKLSQVNGVGSLEEVTSLIQKEL 186
PRK13808 PRK13808
adenylate kinase; Provisional
 19-196 3.18e-24

adenylate kinase; Provisional


Pssm-ID: 172341 [Multi-domain]  Cd Length: 333  Bit Score: 97.27  E-value: 3.18e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364671  19 IFVLGGPGAGKGTQCEKLVKDYSFVHLSAGDLLRAEQGrAGSQYGELIKNCIKEGQIVPQEITLALLRNAISDNVKANkh 98
Cdd:PRK13808   3 LILLGPPGAGKGTQAQRLVQQYGIVQLSTGDMLRAAVA-AGTPVGLKAKDIMASGGLVPDEVVVGIISDRIEQPDAAN-- 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364671  99 KFLIDGFPRKMDQAISFERDIVESKF----ILFFDCPEDIMLER-------LLERGKTSgRSDDNIESIKKRFNTFKETS 167
Cdd:PRK13808  80 GFILDGFPRTVPQAEALDALLKDKQLkldaVVELRVNEGALLARvetrvaeMRARGEEV-RADDTPEVLAKRLASYRAQT 158

                        170       180
                 ....*....|....*....|....*....
gi 398364671 168 MPVIEYFETKSKVVRVRCDRSVEDVYKDV 196
Cdd:PRK13808 159 EPLVHYYSEKRKLLTVDGMMTIDEVTREI 187
PRK14526 PRK14526
adenylate kinase; Provisional
 22-200 3.80e-20

adenylate kinase; Provisional


Pssm-ID: 172992 [Multi-domain]  Cd Length: 211  Bit Score: 84.13  E-value: 3.80e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364671  22 LGGPGAGKGTQCEKLVKDYSFVHLSAGDLLRAEQGRAgSQYGELIKNCIKEGQIVPQEITLALLRNAIsdNVKANKHKFL 101
Cdd:PRK14526   6 LGPPGSGKGTIAKILSNELNYYHISTGDLFRENILNS-TPLGKEIKQIVENGQLVPDSITIKIVEDKI--NTIKNNDNFI 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364671 102 IDGFPRKMDQAISFERDIVESKFILFFdCPEDIMLERLLER---------------------------GKTSGRSDDNIE 154
Cdd:PRK14526  83 LDGFPRNINQAKALDKFLPNIKIINFL-IDEELLIKRLSGRrickscnnifniytlptkekgicdvckGDLYQRKDDKEE 161

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 398364671 155 SIKKRFNTFKETSMPVIEYFETKSKVVRVRCDRSVEDVYKDVQDAI 200
Cdd:PRK14526 162 SLKTRLQEYKLQTKPLIEFYSKCNRLNNIDASKDIDEVKKKLIEII 207
PLN02459 PLN02459
probable adenylate kinase
 22-181 6.50e-20

probable adenylate kinase


Pssm-ID: 215253 [Multi-domain]  Cd Length: 261  Bit Score: 84.51  E-value: 6.50e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364671  22 LGGPGAGKGTQCEKLVKDYSFVHLSAGDLLRAEQGRaGSQYGELIKNCIKEGQIVPQEITLALLRNAISDNVKANKHKFL 101
Cdd:PLN02459  35 LGCPGVGKGTYASRLSKLLGVPHIATGDLVREEIKS-SGPLGAQLKEIVNQGKLVPDEIIFSLLSKRLEAGEEEGESGFI 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364671 102 IDGFPRKMDQAISFERdIVESKFILFFDCPEDIMLERLLER--------------------------------------G 143
Cdd:PLN02459 114 LDGFPRTVRQAEILEG-VTDIDLVVNLKLREEVLVEKCLGRricsecgknfnvadidlkgedgrpgivmppllpppecaS 192

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 398364671 144 KTSGRSDDNIESIKKRFNTFKETSMPVIEYFETKSKVV 181
Cdd:PLN02459 193 KLITRADDTEEVVKARLRVYKEESQPVEDFYRKRGKLL 230
PLN02674 PLN02674
adenylate kinase
 13-200 5.81e-19

adenylate kinase


Pssm-ID: 178279 [Multi-domain]  Cd Length: 244  Bit Score: 81.86  E-value: 5.81e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364671  13 PDQvSVIFVlGGPGAGKGTQCEKLVKDYSFVHLSAGDLLRAEQGrAGSQYGELIKNCIKEGQIVPQEITLALLRNAIsdN 92
Cdd:PLN02674  30 PDK-RLILI-GPPGSGKGTQSPIIKDEYCLCHLATGDMLRAAVA-AKTPLGIKAKEAMDKGELVSDDLVVGIIDEAM--K 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364671  93 VKANKHKFLIDGFPRKMDQAISF----ERDIVESKFILFFDCPEDIMLERLLER--GKTSGRS----------------- 149
Cdd:PLN02674 105 KPSCQKGFILDGFPRTVVQAQKLdemlAKQGAKIDKVLNFAIDDAILEERITGRwiHPSSGRTyhtkfappkvpgvddvt 184

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 398364671 150 --------DDNIESIKKRFNTFKETSMPVIEYFETKSKVVRVRCDRSVEDVYKDVQDAI 200
Cdd:PLN02674 185 gepliqrkDDTAAVLKSRLEAFHKQTEPVIDYYAKKGVVANLHAEKPPKEVTAEVQKAL 243
PTZ00088 PTZ00088
adenylate kinase 1; Provisional
 19-175 5.99e-19

adenylate kinase 1; Provisional


Pssm-ID: 240262 [Multi-domain]  Cd Length: 229  Bit Score: 81.38  E-value: 5.99e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364671  19 IFVLGGPGAGKGTQCEKLVKDYSFVHLSAGDLLRaEQGRAGSQYGELIKNCIKEGQIVPQEITLALLRNAISDNVKANKH 98
Cdd:PTZ00088   9 IVLFGAPGVGKGTFAEILSKKENLKHINMGNILR-EEIKAKTTIGKEIQKVVTSGNLVPDNLVIAIVKDEIAKVTDDCFK 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364671  99 KFLIDGFPRKMDQAISFerdIVESKFILFFDC--PEDIMLERLLER---------------------------------- 142
Cdd:PTZ00088  88 GFILDGFPRNLKQCKEL---GKITNIDLFVNIylPRNILIKKLLGRricntcnrnfniahirsdpydmppilppadcegc 164

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 398364671 143 ---GKTSGRSDDNIESIKKRFNTFKETSMPVIEYFE 175
Cdd:PTZ00088 165 kgnPKLQKRSDDTEEIVAHRLNTYESTNSPIIQFFK 200
PRK14529 PRK14529
adenylate kinase; Provisional
 19-157 4.42e-12

adenylate kinase; Provisional


Pssm-ID: 237746 [Multi-domain]  Cd Length: 223  Bit Score: 62.43  E-value: 4.42e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364671  19 IFVLGGPGAGKGTQCEKLVKDYSFVHLSAGDLLRAEQGrAGSQYGELIKNCIKEGQIVPQEITLALLRNAISdnvKANKH 98
Cdd:PRK14529   3 ILIFGPNGSGKGTQGALVKKKYDLAHIESGAIFREHIG-GGTELGKKAKEYIDRGDLVPDDITIPMILETLK---QDGKN 78

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 398364671  99 KFLIDGFPRKMDQAISFERDIVESKFILffDCPEDIMLERLLERGKTSGR----SDDN------IESIK 157
Cdd:PRK14529  79 GWLLDGFPRNKVQAEKLWEALQKEGMKL--DYVIEILLPREVAKNRIMGRrlckNDNNhpnnifIDAIK 145
AAA_18 pfam13238
AAA domain;
19-154 3.16e-07

AAA domain;


Pssm-ID: 433052 [Multi-domain]  Cd Length: 128  Bit Score: 47.42  E-value: 3.16e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364671   19 IFVLGGPGAGKGTQCEKLVKDYSFvHLSAGDLLRaeqgraGSQYGELIKNCIKEGQIVPQEITLALLRNAISDNVKANKH 98
Cdd:pfam13238   1 ILITGTPGVGKTTLAKELSKRLGF-GDNVRDLAL------ENGLVLGDDPETRESKRLDEDKLDRLLDLLEENAALEEGG 73

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 398364671   99 KFLIDGFPRKMdqaisFERDIVESKFIlFFDCPEDIMLERLLERGKTSGRSDDNIE 154
Cdd:pfam13238  74 NLIIDGHLAEL-----EPERAKDLVGI-VLRASPEELLERLEKRGYEEAKIKENEE 123
AAA_33 pfam13671
AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the ...
 18-160 8.25e-06

AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the AAA superfamily. Many of the proteins in this family are just short fragments so there is no Walker B motif.


Pssm-ID: 463952 [Multi-domain]  Cd Length: 143  Bit Score: 43.84  E-value: 8.25e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364671   18 VIFVLGGPGAGKGTQCEKLVKDYSFVHLSAGDL---LRAEQGRAGSQYGELIKNCIkegQIVPQEITLALL--RNAISD- 91
Cdd:pfam13671   1 LILLVGLPGSGKSTLARRLLEELGAVRLSSDDErkrLFGEGRPSISYYTDATDRTY---ERLHELARIALRagRPVILDa 77

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 398364671   92 -NVKANKHKFLIDGFPRkmdqaISFERDIVeskfilFFDCPEDIMLERLLERGKTSGRSDD----NIESIKKRF 160
Cdd:pfam13671  78 tNLRRDERARLLALARE-----YGVPVRIV------VFEAPEEVLRERLAARARAGGDPSDvpeeVLDRQKARF 140
DTMP_kinase TIGR00041
dTMP kinase; Function: phosphorylation of DTMP to form DTDP in both de novo and salvage ...
 26-196 1.03e-05

dTMP kinase; Function: phosphorylation of DTMP to form DTDP in both de novo and salvage pathways of DTTP synthesis. Catalytic activity: ATP + thymidine 5'-phosphate = ADP + thymidine 5'-diphosphate. [Purines, pyrimidines, nucleosides, and nucleotides, Nucleotide and nucleoside interconversions]


Pssm-ID: 161676  Cd Length: 195  Bit Score: 44.28  E-value: 1.03e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364671   26 GAGKGTQCEKLVKdySFVHLSAGDLLRAEQGraGSQYGELIKNCIKEGQIVPQ-EITLALLRNA-----ISDNVK-ANKH 98
Cdd:TIGR00041  13 GAGKTTQANLLKK--LLQENGYDVLFTREPG--GTPIGEKIRELLLNENDEPLtDKAEALLFAAdrhehLEDKIKpALAE 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364671   99 KFLI------------DGFPRKMDQAISFE--RDIVESK--FILFFDCPEDIMLERLlergktSGRSDDNIESIKKR--F 160
Cdd:TIGR00041  89 GKLVisdryvfssiayQGGARGIDEDLVLElnEDALGDMpdLTIYLDIDPEVALERL------RKRGELDREEFEKLdfF 162

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 398364671  161 NTFKETSMpviEYFETKSKVVRVRCDRSVEDVYKDV 196
Cdd:TIGR00041 163 EKVRQRYL---ELADKEKSIHVIDATNSVEEVEQDI 195
Tmk COG0125
Thymidylate kinase [Nucleotide transport and metabolism]; Thymidylate kinase is part of the ...
 23-204 3.95e-04

Thymidylate kinase [Nucleotide transport and metabolism]; Thymidylate kinase is part of the Pathway/BioSystem: Thymidylate biosynthesis


Pssm-ID: 439895 [Multi-domain]  Cd Length: 206  Bit Score: 39.76  E-value: 3.95e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364671  23 GGPGAGKGTQCEKLVkdysfvhlsagDLLRAeQGRA--------GSQYGELIKNCIKEGQIVPQEITLALL----RNAIS 90
Cdd:COG0125   10 GIDGSGKSTQIKLLA-----------EYLEA-RGYDvvltrepgGTPLGEAIRELLLGDNEDMSPRTELLLfaadRAQHV 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364671  91 DNV--KA-NKHKFLI-----------DGFPRKMDQAI-----SFERDIVESKFILFFDCPEDIMLERLLERGKTSGRSD- 150
Cdd:COG0125   78 EEVirPAlAAGKIVIcdryvdsslayQGGGRGLDLEWirqlnRFATGGLKPDLTILLDVPPEVALARARARGGELDRFEs 157

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 398364671 151 DNIESIKKRFNTFKEtsmpVIEyfETKSKVVRVRCDRSVEDVYKDVQDAIRDSL 204
Cdd:COG0125  158 EDLEFHERVREGYLE----LAA--KEPERIVVIDASQSIEEVHAEIREALAELL 205
Thymidylate_kin pfam02223
Thymidylate kinase;
23-196 1.16e-03

Thymidylate kinase;


Pssm-ID: 396690  Cd Length: 184  Bit Score: 38.44  E-value: 1.16e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364671   23 GGPGAGKGTQCEKLVKDYSFVHLSAgdLLRAEQGraGSQYGELIKNCIKEGQIVpQEITLALLRNA-----ISDNVK-AN 96
Cdd:pfam02223   3 GLDGAGKTTQAELLKERLKEQGIKV--VFTREPG--GTPIGEKIRELLLRNEEL-SPLTEALLFAAdriqhLEQKIKpAL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364671   97 KHKFLI------------DGFPRKMDQAISFERDIVESK--FILFFDCPEDIMLERLLERGKtsgrSDDNIESIKKRFNT 162
Cdd:pfam02223  78 KQGKTVivdrylfsgiayQGAKGGDLDLVLSLNPDVPGKpdLTFLLDVDPEVALKRLRRRGE----LEKTEFEQLDFLRK 153

                         170       180       190
                  ....*....|....*....|....*....|....
gi 398364671  163 FKETSMpviEYFETKSKVVRVRCDRSVEDVYKDV 196
Cdd:pfam02223 154 VRERYL---ELAKFDERIKIIDASLSIEEVHEEI 184
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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