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Conserved domains on  [gi|398364695|ref|NP_012904|]
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Mak11p [Saccharomyces cerevisiae S288C]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
98-394 3.89e-34

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 132.34  E-value: 3.89e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364695  98 PIFHFQAHSLSIKCLAVSR--RYLVSGSNDEHIRIYDLQKRKELGTLLSHQGSITALQFSHpasssedaavskgskNSKW 175
Cdd:COG2319  112 LLRTLTGHTGAVRSVAFSPdgKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSP---------------DGKL 176

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364695 176 LLSASEDHKIMVWRVKDWETVGTLKGHTARVNDVDIHPTNRIAISVSDDHSIRLWNLMTlrNAAVLKLRKYNTNGTCVRW 255
Cdd:COG2319  177 LASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLAT--GKLLRTLTGHSGSVRSVAF 254

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364695 256 LgAKGDYFAVGLRDR-VLIYETGSAKVfkeivfqRKTLMHIETHILPF----DNKeYLSVGISDGNVHFYpceelfeKVE 330
Cdd:COG2319  255 S-PDGRLLASGSADGtVRLWDLATGEL-------LRTLTGHSGGVNSVafspDGK-LLASGSDDGTVRLW-------DLA 318

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 398364695 331 ENekqeddddkediSPAFSLLGHTNRIKDFKFYTNefGTYLVTIGSDGKIVVWDMSTKEQVAVY 394
Cdd:COG2319  319 TG------------KLLRTLTGHTGAVRSVAFSPD--GKTLASGSDDGTVRLWDLATGELLRTL 368
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
98-394 3.89e-34

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 132.34  E-value: 3.89e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364695  98 PIFHFQAHSLSIKCLAVSR--RYLVSGSNDEHIRIYDLQKRKELGTLLSHQGSITALQFSHpasssedaavskgskNSKW 175
Cdd:COG2319  112 LLRTLTGHTGAVRSVAFSPdgKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSP---------------DGKL 176

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364695 176 LLSASEDHKIMVWRVKDWETVGTLKGHTARVNDVDIHPTNRIAISVSDDHSIRLWNLMTlrNAAVLKLRKYNTNGTCVRW 255
Cdd:COG2319  177 LASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLAT--GKLLRTLTGHSGSVRSVAF 254

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364695 256 LgAKGDYFAVGLRDR-VLIYETGSAKVfkeivfqRKTLMHIETHILPF----DNKeYLSVGISDGNVHFYpceelfeKVE 330
Cdd:COG2319  255 S-PDGRLLASGSADGtVRLWDLATGEL-------LRTLTGHSGGVNSVafspDGK-LLASGSDDGTVRLW-------DLA 318

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 398364695 331 ENekqeddddkediSPAFSLLGHTNRIKDFKFYTNefGTYLVTIGSDGKIVVWDMSTKEQVAVY 394
Cdd:COG2319  319 TG------------KLLRTLTGHTGAVRSVAFSPD--GKTLASGSDDGTVRLWDLATGELLRTL 368
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 98-384 2.89e-32

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 124.37  E-value: 2.89e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364695  98 PIFHFQAHSLSIKCLAVS--RRYLVSGSNDEHIRIYDLQKRKELGTLLSHQGSITALQFSHpasssedaavskgskNSKW 175
Cdd:cd00200   43 LLRTLKGHTGPVRDVAASadGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSP---------------DGRI 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364695 176 LLSASEDHKIMVWRVKDWETVGTLKGHTARVNDVDIHPTNRIAISVSDDHSIRLWNLMTLRNAAVLKLrkYNTNGTCVRW 255
Cdd:cd00200  108 LSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTG--HTGEVNSVAF 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364695 256 LGAKGDYFAVGLRDRVLIYETGSAKVFKEIVFQRKTLMHIETHilpfDNKEYLSVGISDGNVHFYPceelfekveenekq 335
Cdd:cd00200  186 SPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFS----PDGYLLASGSEDGTIRVWD-------------- 247

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 398364695 336 eddddKEDISPAFSLLGHTNRIKDFKFYTNefGTYLVTIGSDGKIVVWD 384
Cdd:cd00200  248 -----LRTGECVQTLSGHTNSVTSLAWSPD--GKRLASGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 192-231 2.17e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 50.00  E-value: 2.17e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 398364695   192 DWETVGTLKGHTARVNDVDIHPTNRIAISVSDDHSIRLWN 231
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
193-231 7.36e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 48.50  E-value: 7.36e-08
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 398364695  193 WETVGTLKGHTARVNDVDIHPTNRIAISVSDDHSIRLWN 231
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
98-394 3.89e-34

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 132.34  E-value: 3.89e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364695  98 PIFHFQAHSLSIKCLAVSR--RYLVSGSNDEHIRIYDLQKRKELGTLLSHQGSITALQFSHpasssedaavskgskNSKW 175
Cdd:COG2319  112 LLRTLTGHTGAVRSVAFSPdgKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSP---------------DGKL 176

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364695 176 LLSASEDHKIMVWRVKDWETVGTLKGHTARVNDVDIHPTNRIAISVSDDHSIRLWNLMTlrNAAVLKLRKYNTNGTCVRW 255
Cdd:COG2319  177 LASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLAT--GKLLRTLTGHSGSVRSVAF 254

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364695 256 LgAKGDYFAVGLRDR-VLIYETGSAKVfkeivfqRKTLMHIETHILPF----DNKeYLSVGISDGNVHFYpceelfeKVE 330
Cdd:COG2319  255 S-PDGRLLASGSADGtVRLWDLATGEL-------LRTLTGHSGGVNSVafspDGK-LLASGSDDGTVRLW-------DLA 318

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 398364695 331 ENekqeddddkediSPAFSLLGHTNRIKDFKFYTNefGTYLVTIGSDGKIVVWDMSTKEQVAVY 394
Cdd:COG2319  319 TG------------KLLRTLTGHTGAVRSVAFSPD--GKTLASGSDDGTVRLWDLATGELLRTL 368
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 98-384 2.89e-32

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 124.37  E-value: 2.89e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364695  98 PIFHFQAHSLSIKCLAVS--RRYLVSGSNDEHIRIYDLQKRKELGTLLSHQGSITALQFSHpasssedaavskgskNSKW 175
Cdd:cd00200   43 LLRTLKGHTGPVRDVAASadGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSP---------------DGRI 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364695 176 LLSASEDHKIMVWRVKDWETVGTLKGHTARVNDVDIHPTNRIAISVSDDHSIRLWNLMTLRNAAVLKLrkYNTNGTCVRW 255
Cdd:cd00200  108 LSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTG--HTGEVNSVAF 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364695 256 LGAKGDYFAVGLRDRVLIYETGSAKVFKEIVFQRKTLMHIETHilpfDNKEYLSVGISDGNVHFYPceelfekveenekq 335
Cdd:cd00200  186 SPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFS----PDGYLLASGSEDGTIRVWD-------------- 247

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 398364695 336 eddddKEDISPAFSLLGHTNRIKDFKFYTNefGTYLVTIGSDGKIVVWD 384
Cdd:cd00200  248 -----LRTGECVQTLSGHTNSVTSLAWSPD--GKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 98-393 8.66e-29

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 114.74  E-value: 8.66e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364695  98 PIFHFQAHSLSIKCLAVS--RRYLVSGSNDEHIRIYDLQKRKELGTLLSHQGSITALQFSHpasssedaavskgskNSKW 175
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSpdGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASA---------------DGTY 65

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364695 176 LLSASEDHKIMVWRVKDWETVGTLKGHTARVNDVDIHPTNRIAISVSDDHSIRLWNLMTLRNAAVLklrKYNTNG-TCVR 254
Cdd:cd00200   66 LASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTL---RGHTDWvNSVA 142

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364695 255 WLGaKGDYFAVGLRDR-VLIYETGSAKVFKEIVFQRKTLMHIETHIlpfDNKEYLSvGISDGNVHFYPCEELFEKVeene 333
Cdd:cd00200  143 FSP-DGTFVASSSQDGtIKLWDLRTGKCVATLTGHTGEVNSVAFSP---DGEKLLS-SSSDGTIKLWDLSTGKCLG---- 213

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364695 334 kqeddddkedispafSLLGHTNRIKDFKFYTNefGTYLVTIGSDGKIVVWDMSTKEQVAV 393
Cdd:cd00200  214 ---------------TLRGHENGVNSVAFSPD--GYLLASGSEDGTIRVWDLRTGECVQT 256
WD40 COG2319
WD40 repeat [General function prediction only];
102-234 7.72e-28

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 114.62  E-value: 7.72e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364695 102 FQAHSLSIKCLAVSR--RYLVSGSNDEHIRIYDLQKRKELGTLLSHQGSITALQFShP-----ASSSEDAAVS------- 167
Cdd:COG2319  242 LTGHSGSVRSVAFSPdgRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFS-PdgkllASGSDDGTVRlwdlatg 320

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364695 168 ------KG----------SKNSKWLLSASEDHKIMVWRVKDWETVGTLKGHTARVNDVDIHPTNRIAISVSDDHSIRLWN 231
Cdd:COG2319  321 kllrtlTGhtgavrsvafSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWD 400


                 ...
gi 398364695 232 LMT 234
Cdd:COG2319  401 LAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 93-283 1.31e-25

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 105.88  E-value: 1.31e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364695  93 TPHFMPIFHFQAHSLSIKCLAVSR--RYLVSGSNDEHIRIYDLQKRKELGTLLSHQGSITALQFSHpasssedaavskgs 170
Cdd:cd00200  122 VETGKCLTTLRGHTDWVNSVAFSPdgTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSP-------------- 187

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364695 171 kNSKWLLSASEDHKIMVWRVKDWETVGTLKGHTARVNDVDIHPTNRIAISVSDDHSIRLWNLMTLRnaAVLKLRKYNTNG 250
Cdd:cd00200  188 -DGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGE--CVQTLSGHTNSV 264

                        170       180       190
                 ....*....|....*....|....*....|...
gi 398364695 251 TCVRWLgAKGDYFAVGLRDrvliyetGSAKVFK 283
Cdd:cd00200  265 TSLAWS-PDGKRLASGSAD-------GTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 138-396 6.17e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 63.12  E-value: 6.17e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364695 138 ELGTLLSHQGSITALQFShpasssedaavskgsKNSKWLLSASEDHKIMVWRVKDWETVGTLKGHTARVNDVDIHPTNRI 217
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFS---------------PDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTY 65

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364695 218 AISVSDDHSIRLWNLMTlrnaavlklrkyntnGTCVRwlgakgdyfavglrdrvliyetgsakvfkeivfqrktlmhiet 297
Cdd:cd00200   66 LASGSSDKTIRLWDLET---------------GECVR------------------------------------------- 87

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364695 298 hilpfdnkeylsvgisdgnvhfypceelfekveenekqeddddkedispafSLLGHTNRIKDFKFYTNefGTYLVTIGSD 377
Cdd:cd00200   88 ---------------------------------------------------TLTGHTSYVSSVAFSPD--GRILSSSSRD 114

                        250
                 ....*....|....*....
gi 398364695 378 GKIVVWDMSTKEQVAVYDC 396
Cdd:cd00200  115 KTIKVWDVETGKCLTTLRG 133
WD40 COG2319
WD40 repeat [General function prediction only];
112-395 1.77e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 62.62  E-value: 1.77e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364695 112 LAVSRRYLVSGSNDEHIRIYDLQKRKELGTLLSHQGSITALQFSHPASssedaavskgsknskWLLSASEDHKIMVWRVK 191
Cdd:COG2319    2 LSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGA---------------RLAAGAGDLTLLLLDAA 66

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364695 192 DWETVGTLKGHTARVNDVDIHPTNRIAISVSDDHSIRLWNLMTlrNAAVLKLRKYNTNGTCVRWlGAKGDYFAVGLRDR- 270
Cdd:COG2319   67 AGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLAT--GLLLRTLTGHTGAVRSVAF-SPDGKTLASGSADGt 143

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364695 271 VLIYETGSAKvfkeivfQRKTLMHIETHILPF----DNKeYLSVGISDGNVHFYPCEELfekveenekqeddddkediSP 346
Cdd:COG2319  144 VRLWDLATGK-------LLRTLTGHSGAVTSVafspDGK-LLASGSDDGTVRLWDLATG-------------------KL 196

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 398364695 347 AFSLLGHTNRIKDFKFYTNefGTYLVTIGSDGKIVVWDMSTKEQVAVYD 395
Cdd:COG2319  197 LRTLTGHTGAVRSVAFSPD--GKLLASGSADGTVRLWDLATGKLLRTLT 243
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 192-231 2.17e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 50.00  E-value: 2.17e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 398364695   192 DWETVGTLKGHTARVNDVDIHPTNRIAISVSDDHSIRLWN 231
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
193-231 7.36e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 48.50  E-value: 7.36e-08
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 398364695  193 WETVGTLKGHTARVNDVDIHPTNRIAISVSDDHSIRLWN 231
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 98-132 2.40e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.45  E-value: 2.40e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 398364695    98 PIFHFQAHSLSIKCLAVS--RRYLVSGSNDEHIRIYD 132
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSpdGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
98-132 6.78e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.32  E-value: 6.78e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 398364695   98 PIFHFQAHSLSIKCLAVS--RRYLVSGSNDEHIRIYD 132
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAFSpdGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 135-188 8.72e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.91  E-value: 8.72e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 398364695   135 KRKELGTLLSHQGSITALQFSHpasssedaavskgskNSKWLLSASEDHKIMVW 188
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSP---------------DGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
136-188 1.15e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.55  E-value: 1.15e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 398364695  136 RKELGTLLSHQGSITALQFSHpasssedaavskgskNSKWLLSASEDHKIMVW 188
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSP---------------DGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 345-384 1.97e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 35.75  E-value: 1.97e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 398364695   345 SPAFSLLGHTNRIKDFKFytNEFGTYLVTIGSDGKIVVWD 384
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAF--SPDGKYLASGSDDGTIKLWD 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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