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Conserved domains on  [gi|6323763|ref|NP_013834|]
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ribosomal 40S subunit protein ASC1 [Saccharomyces cerevisiae S288C]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 10077586)

WD40 repeat domain-containing protein similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 9-314 1.76e-87

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 263.81  E-value: 1.76e-87
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323763    9 LRGTLEGHNGWVTSLATSAgQPNLLLSASRDKTLISWKLTGDDQKfgvpvRSFKGHSHIVQDCTLTADGAYALSASWDKT 88
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSP-DGKLLATGSGDGTIKVWDLETGELL-----RTLKGHTGPVRDVAASADGTYLASGSSDKT 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323763   89 LRLWDVATGETYQRFVGHKSDVMSVDIDKKASMIISGSRDKTIKVW-TIKGQCLATLLGHNDWVSQVRVVPNEKadddsv 167
Cdd:cd00200  75 IRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWdVETGKCLTTLRGHTDWVNSVAFSPDGT------ 148

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323763  168 TIISAGNDKMVKAWNLNQFQIEADFIGHNSNINTLTASPDGTLIASAGKDGEIMLWNLAAKKAMYTLSAQDE-VFSLAFS 246
Cdd:cd00200 149 FVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENgVNSVAFS 228

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6323763  247 PNRYWLAAATATG-IKVFSLDPQYLVDDLrpefagysKAAEPHAVSLAWSADGQTLFAGYTDNVIRVWQ 314
Cdd:cd00200 229 PDGYLLASGSEDGtIRVWDLRTGECVQTL--------SGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 9-314 1.76e-87

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 263.81  E-value: 1.76e-87
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323763    9 LRGTLEGHNGWVTSLATSAgQPNLLLSASRDKTLISWKLTGDDQKfgvpvRSFKGHSHIVQDCTLTADGAYALSASWDKT 88
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSP-DGKLLATGSGDGTIKVWDLETGELL-----RTLKGHTGPVRDVAASADGTYLASGSSDKT 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323763   89 LRLWDVATGETYQRFVGHKSDVMSVDIDKKASMIISGSRDKTIKVW-TIKGQCLATLLGHNDWVSQVRVVPNEKadddsv 167
Cdd:cd00200  75 IRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWdVETGKCLTTLRGHTDWVNSVAFSPDGT------ 148

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323763  168 TIISAGNDKMVKAWNLNQFQIEADFIGHNSNINTLTASPDGTLIASAGKDGEIMLWNLAAKKAMYTLSAQDE-VFSLAFS 246
Cdd:cd00200 149 FVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENgVNSVAFS 228

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6323763  247 PNRYWLAAATATG-IKVFSLDPQYLVDDLrpefagysKAAEPHAVSLAWSADGQTLFAGYTDNVIRVWQ 314
Cdd:cd00200 229 PDGYLLASGSEDGtIRVWDLRTGECVQTL--------SGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
9-315 1.24e-66

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 214.39  E-value: 1.24e-66
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323763    9 LRGTLEGHNGWVTSLATSAGqPNLLLSASRDKTLISWKLTGddqkfGVPVRSFKGHSHIVQDCTLTADGAYALSASWDKT 88
Cdd:COG2319  70 LLATLLGHTAAVLSVAFSPD-GRLLASASADGTVRLWDLAT-----GLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGT 143

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323763   89 LRLWDVATGETYQRFVGHKSDVMSVDIDKKASMIISGSRDKTIKVWTIK-GQCLATLLGHNDWVSQVRVVPNEKadddsv 167
Cdd:COG2319 144 VRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLAtGKLLRTLTGHTGAVRSVAFSPDGK------ 217

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323763  168 TIISAGNDKMVKAWNLNQFQIEADFIGHNSNINTLTASPDGTLIASAGKDGEIMLWNLAAKKAMYTLSAQ-DEVFSLAFS 246
Cdd:COG2319 218 LLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHsGGVNSVAFS 297

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323763  247 PNRYWLAAATATG-IKVFSLDPQYLVDDLRPEFAGyskaaephAVSLAWSADGQTLFAGYTDNVIRVWQV 315
Cdd:COG2319 298 PDGKLLASGSDDGtVRLWDLATGKLLRTLTGHTGA--------VRSVAFSPDGKTLASGSDDGTVRLWDL 359
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 50-226 1.00e-09

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 59.72  E-value: 1.00e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323763    50 DDQKFGVPVRSFKGHSHIVQDCTLTADGAYALSASWDKTLRLWDVATGETYQRFVGHKSDVMSVDIDK-KASMIISGSRD 128
Cdd:PLN00181 518 DGRDIHYPVVELASRSKLSGICWNSYIKSQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSaDPTLLASGSDD 597

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323763   129 KTIKVW---------TIK--------------GQCLA---------------------TLLGHNDWVSQVRVVpnekadd 164
Cdd:PLN00181 598 GSVKLWsinqgvsigTIKtkaniccvqfpsesGRSLAfgsadhkvyyydlrnpklplcTMIGHSKTVSYVRFV------- 670

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6323763   165 DSVTIISAGNDKMVKAWNL-------NQFQIEAdFIGHNSNINTLTASPDGTLIASAGKDGEIMLWNLA 226
Cdd:PLN00181 671 DSSTLVSSSTDNTLKLWDLsmsisgiNETPLHS-FMGHTNVKNFVGLSVSDGYIATGSETNEVFVYHKA 738
WD40 pfam00400
WD domain, G-beta repeat;
55-93 7.49e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.03  E-value: 7.49e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 6323763     55 GVPVRSFKGHSHIVQDCTLTADGAYALSASWDKTLRLWD 93
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 55-93 2.33e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.84  E-value: 2.33e-06
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 6323763      55 GVPVRSFKGHSHIVQDCTLTADGAYALSASWDKTLRLWD 93
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 9-314 1.76e-87

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 263.81  E-value: 1.76e-87
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323763    9 LRGTLEGHNGWVTSLATSAgQPNLLLSASRDKTLISWKLTGDDQKfgvpvRSFKGHSHIVQDCTLTADGAYALSASWDKT 88
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSP-DGKLLATGSGDGTIKVWDLETGELL-----RTLKGHTGPVRDVAASADGTYLASGSSDKT 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323763   89 LRLWDVATGETYQRFVGHKSDVMSVDIDKKASMIISGSRDKTIKVW-TIKGQCLATLLGHNDWVSQVRVVPNEKadddsv 167
Cdd:cd00200  75 IRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWdVETGKCLTTLRGHTDWVNSVAFSPDGT------ 148

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323763  168 TIISAGNDKMVKAWNLNQFQIEADFIGHNSNINTLTASPDGTLIASAGKDGEIMLWNLAAKKAMYTLSAQDE-VFSLAFS 246
Cdd:cd00200 149 FVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENgVNSVAFS 228

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6323763  247 PNRYWLAAATATG-IKVFSLDPQYLVDDLrpefagysKAAEPHAVSLAWSADGQTLFAGYTDNVIRVWQ 314
Cdd:cd00200 229 PDGYLLASGSEDGtIRVWDLRTGECVQTL--------SGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
9-315 1.24e-66

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 214.39  E-value: 1.24e-66
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323763    9 LRGTLEGHNGWVTSLATSAGqPNLLLSASRDKTLISWKLTGddqkfGVPVRSFKGHSHIVQDCTLTADGAYALSASWDKT 88
Cdd:COG2319  70 LLATLLGHTAAVLSVAFSPD-GRLLASASADGTVRLWDLAT-----GLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGT 143

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323763   89 LRLWDVATGETYQRFVGHKSDVMSVDIDKKASMIISGSRDKTIKVWTIK-GQCLATLLGHNDWVSQVRVVPNEKadddsv 167
Cdd:COG2319 144 VRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLAtGKLLRTLTGHTGAVRSVAFSPDGK------ 217

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323763  168 TIISAGNDKMVKAWNLNQFQIEADFIGHNSNINTLTASPDGTLIASAGKDGEIMLWNLAAKKAMYTLSAQ-DEVFSLAFS 246
Cdd:COG2319 218 LLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHsGGVNSVAFS 297

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323763  247 PNRYWLAAATATG-IKVFSLDPQYLVDDLRPEFAGyskaaephAVSLAWSADGQTLFAGYTDNVIRVWQV 315
Cdd:COG2319 298 PDGKLLASGSDDGtVRLWDLATGKLLRTLTGHTGA--------VRSVAFSPDGKTLASGSDDGTVRLWDL 359
WD40 COG2319
WD40 repeat [General function prediction only];
9-317 1.13e-65

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 211.69  E-value: 1.13e-65
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323763    9 LRGTLEGHNGWVTSLATSA-GQpnLLLSASRDKTLISWKLTGddqkfGVPVRSFKGHSHIVQDCTLTADGAYALSASWDK 87
Cdd:COG2319 112 LLRTLTGHTGAVRSVAFSPdGK--TLASGSADGTVRLWDLAT-----GKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDG 184

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323763   88 TLRLWDVATGETYQRFVGHKSDVMSVDIDKKASMIISGSRDKTIKVWTIK-GQCLATLLGHNDWVSQVRVVPnekaddDS 166
Cdd:COG2319 185 TVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLAtGKLLRTLTGHSGSVRSVAFSP------DG 258

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323763  167 VTIISAGNDKMVKAWNLNQFQIEADFIGHNSNINTLTASPDGTLIASAGKDGEIMLWNLAAKKAMYTLSA-QDEVFSLAF 245
Cdd:COG2319 259 RLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGhTGAVRSVAF 338

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 6323763  246 SPNRYWLAAATATG-IKVFSLDPQylvdDLRPEFAGYSKAAEphavSLAWSADGQTLFAGYTDNVIRVWQVMT 317
Cdd:COG2319 339 SPDGKTLASGSDDGtVRLWDLATG----ELLRTLTGHTGAVT----SVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
6-315 1.32e-58

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 193.59  E-value: 1.32e-58
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323763    6 VLVLRGTLEGHNGWVTSLATSAGQPNLLLSASRDKTLISWKLTGddqkfgVPVRSFKGHSHIVQDCTLTADGAYALSASW 85
Cdd:COG2319  25 LGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAG------ALLATLLGHTAAVLSVAFSPDGRLLASASA 98

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323763   86 DKTLRLWDVATGETYQRFVGHKSDVMSVDIDKKASMIISGSRDKTIKVWTIK-GQCLATLLGHNDWVSQVRVVPnekadd 164
Cdd:COG2319  99 DGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLAtGKLLRTLTGHSGAVTSVAFSP------ 172

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323763  165 DSVTIISAGNDKMVKAWNLNQFQIEADFIGHNSNINTLTASPDGTLIASAGKDGEIMLWNLAAKKAMYTLSA-QDEVFSL 243
Cdd:COG2319 173 DGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGhSGSVRSV 252

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 6323763  244 AFSPNRYWLAAATATG-IKVFSLDPQYLVDDLRPEFAGyskaaephAVSLAWSADGQTLFAGYTDNVIRVWQV 315
Cdd:COG2319 253 AFSPDGRLLASGSADGtVRLWDLATGELLRTLTGHSGG--------VNSVAFSPDGKLLASGSDDGTVRLWDL 317
WD40 COG2319
WD40 repeat [General function prediction only];
42-315 1.62e-44

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 156.61  E-value: 1.62e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323763   42 LISWKLTGDDQKFGVPVRSFKGHSHIVQDCTLTADGAYALSASWDKTLRLWDVATGETYQRFVGHKSDVMSVDIDKKASM 121
Cdd:COG2319  13 SADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRL 92

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323763  122 IISGSRDKTIKVWTIK-GQCLATLLGHNDWVSQVRVVPnekaddDSVTIISAGNDKMVKAWNLNQFQIEADFIGHNSNIN 200
Cdd:COG2319  93 LASASADGTVRLWDLAtGLLLRTLTGHTGAVRSVAFSP------DGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVT 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323763  201 TLTASPDGTLIASAGKDGEIMLWNLAAKKAMYTLSA-QDEVFSLAFSPNRYWLAAATATG-IKVFSLDPQYLVDDLRPEf 278
Cdd:COG2319 167 SVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGhTGAVRSVAFSPDGKLLASGSADGtVRLWDLATGKLLRTLTGH- 245

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 6323763  279 agyskaaEPHAVSLAWSADGQTLFAGYTDNVIRVWQV 315
Cdd:COG2319 246 -------SGSVRSVAFSPDGRLLASGSADGTVRLWDL 275
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 50-226 1.00e-09

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 59.72  E-value: 1.00e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323763    50 DDQKFGVPVRSFKGHSHIVQDCTLTADGAYALSASWDKTLRLWDVATGETYQRFVGHKSDVMSVDIDK-KASMIISGSRD 128
Cdd:PLN00181 518 DGRDIHYPVVELASRSKLSGICWNSYIKSQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSaDPTLLASGSDD 597

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323763   129 KTIKVW---------TIK--------------GQCLA---------------------TLLGHNDWVSQVRVVpnekadd 164
Cdd:PLN00181 598 GSVKLWsinqgvsigTIKtkaniccvqfpsesGRSLAfgsadhkvyyydlrnpklplcTMIGHSKTVSYVRFV------- 670

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6323763   165 DSVTIISAGNDKMVKAWNL-------NQFQIEAdFIGHNSNINTLTASPDGTLIASAGKDGEIMLWNLA 226
Cdd:PLN00181 671 DSSTLVSSSTDNTLKLWDLsmsisgiNETPLHS-FMGHTNVKNFVGLSVSDGYIATGSETNEVFVYHKA 738
PTZ00421 PTZ00421
coronin; Provisional
 1-182 5.53e-07

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 50.66  E-value: 5.53e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323763     1 MASNEVLVLrgtleGHNGWVTSLATSAGQPNLLLSASRDKTLISWKL--TGDDQKFGVPVRSFKGHSHIVQDCTL--TAD 76
Cdd:PTZ00421  64 LASNPPILL-----GQEGPIIDVAFNPFDPQKLFTASEDGTIMGWGIpeEGLTQNISDPIVHLQGHTKKVGIVSFhpSAM 138

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323763    77 GAYAlSASWDKTLRLWDVATGETYQRFVGHKSDVMSVDIDKKASMIISGSRDKTIKVWTIK-GQCLATLLGHNDWVSQvR 155
Cdd:PTZ00421 139 NVLA-SAGADMVVNVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRdGTIVSSVEAHASAKSQ-R 216

                        170       180       190
                 ....*....|....*....|....*....|.
gi 6323763   156 VVPNEKADddsvTIISAGNDKM----VKAWN 182
Cdd:PTZ00421 217 CLWAKRKD----LIITLGCSKSqqrqIMLWD 243
WD40 pfam00400
WD domain, G-beta repeat;
55-93 7.49e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.03  E-value: 7.49e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 6323763     55 GVPVRSFKGHSHIVQDCTLTADGAYALSASWDKTLRLWD 93
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 55-93 2.33e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.84  E-value: 2.33e-06
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 6323763      55 GVPVRSFKGHSHIVQDCTLTADGAYALSASWDKTLRLWD 93
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
97-134 4.99e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.72  E-value: 4.99e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 6323763     97 GETYQRFVGHKSDVMSVDIDKKASMIISGSRDKTIKVW 134
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 96-134 5.00e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.68  E-value: 5.00e-06
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 6323763      96 TGETYQRFVGHKSDVMSVDIDKKASMIISGSRDKTIKVW 134
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 185-224 5.97e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.68  E-value: 5.97e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 6323763     185 QFQIEADFIGHNSNINTLTASPDGTLIASAGKDGEIMLWN 224
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 169-315 8.17e-06

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 47.39  E-value: 8.17e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323763   169 IISAGNDKMVKAWNLNQFQIEADFIGHNSNINTLT-ASPDGTLIASAGKDGEIMLWNLAAKKAMYTLSAQDEVFSLAFsp 247
Cdd:PLN00181 548 VASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDySSADPTLLASGSDDGSVKLWSINQGVSIGTIKTKANICCVQF-- 625

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6323763   248 nrywlAAATATGIKVFSLDPQYLVDDLR-PEFAGYSKAAEPHAVSLAWSADGQTLFAGYTDNVIRVWQV 315
Cdd:PLN00181 626 -----PSESGRSLAFGSADHKVYYYDLRnPKLPLCTMIGHSKTVSYVRFVDSSTLVSSSTDNTLKLWDL 689
WD40 pfam00400
WD domain, G-beta repeat;
192-224 1.51e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.56  E-value: 1.51e-05
                          10        20        30
                  ....*....|....*....|....*....|...
gi 6323763    192 FIGHNSNINTLTASPDGTLIASAGKDGEIMLWN 224
Cdd:pfam00400   7 LEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
 199-307 1.52e-04

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 43.49  E-value: 1.52e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323763   199 INTLTASPDGTLIASAGKDGEIMLWNLAAKKA--MYTLSAQDEVFSLAFSPNRYWLAAATATG-----IKVFSLD---PQ 268
Cdd:COG4946  391 VFNPVWSPDGKKIAFTDNRGRLWVVDLASGKVrkVDTDGYGDGISDLAWSPDSKWLAYSKPGPnqlsqIFLYDVEtgkTV 470

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 6323763   269 YLVDDLRpefagyskaaepHAVSLAWSADGQTL-FAGYTD 307
Cdd:COG4946  471 QLTDGRY------------DDGSPAFSPDGKYLyFLSSRD 498
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 137-182 4.88e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.29  E-value: 4.88e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 6323763     137 KGQCLATLLGHNDWVSQVRVVPNEKadddsvTIISAGNDKMVKAWN 182
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGK------YLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
138-182 1.95e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.40  E-value: 1.95e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 6323763    138 GQCLATLLGHNDWVSQVRVVPNEKadddsvTIISAGNDKMVKAWN 182
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGK------LLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
9-45 3.66e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 34.63  E-value: 3.66e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 6323763      9 LRGTLEGHNGWVTSLATSAGQpNLLLSASRDKTLISW 45
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAFSPDG-KLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 12-46 3.71e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 34.60  E-value: 3.71e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 6323763      12 TLEGHNGWVTSLATSAGQpNLLLSASRDKTLISWK 46
Cdd:smart00320   7 TLKGHTGPVTSVAFSPDG-KYLASGSDDGTIKLWD 40
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 84-218 7.77e-03

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 37.74  E-value: 7.77e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323763     84 SWDKTLRLWDVATGETYQRFVGHKSDVMSVDIDKKASMIISGSRDKTIKVWTIkgqclatllghndwvsqVRVVPNEKAD 163
Cdd:pfam20426 101 NWENSFQVISLNDGRMVQSIRQHKDVVSCVAVTSDGSILATGSYDTTVMVWEV-----------------LRGRSSEKRS 163

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 6323763    164 DDSVTIISAGNDKMVKawnlNQFQIeadFIGHNSNINTLTASPDGTLIASAGKDG 218
Cdd:pfam20426 164 RNTQTEFPRKDHVIAE----TPFHI---LCGHDDIITCLYVSVELDIVISGSKDG 211
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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