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Conserved domains on  [gi|6324615|ref|NP_014685|]
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ubiquitin-binding protein CUE5 [Saccharomyces cerevisiae S288C]

Protein Classification

CUE domain-containing protein( domain architecture ID 10198930)

CUE domain-containing protein similar to Saccharomyces cerevisiae ubiquitin-binding protein CUE5 that connects the ubiquitin pathway to autophagy by functioning as a ubiquitin-ATG8 adapter

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CUE_Cue5p_like cd14372
CUE domain found in yeast ubiquitin-binding protein CUE5 (Cue5p), donuts protein 1 (DON1p) and ...
 97-141 1.04e-17

CUE domain found in yeast ubiquitin-binding protein CUE5 (Cue5p), donuts protein 1 (DON1p) and similar proteins; Cue5p, also called coupling of ubiquitin conjugation to ER degradation protein 5, is encoded by the open reading frame (ORF) Yor042. It contains a CUE domain which exhibits weak ubiquitin binding properties. Donuts protein 1 (DON1p) is encoded by the ORF YDR273w. It localizes specifically to the prospore membrane and is expressed exclusively during meiosis. DON1p may function as a unique marker to investigate the defects associated with the impaired function of the meiotic plaque in the mpc- mutants.


:

Pssm-ID: 270555  Cd Length: 45  Bit Score: 76.14  E-value: 1.04e-17
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 6324615   97 KENPILQELKDAFPNLEEKYIKAVIIASQGVLSPAFNALLFLSDP 141
Cdd:cd14372   1 EQESAIKILKEAFPDVDDKVIKAILIASQGDLEPAFNALLGLTDP 45
 
Name Accession Description Interval E-value
CUE_Cue5p_like cd14372
CUE domain found in yeast ubiquitin-binding protein CUE5 (Cue5p), donuts protein 1 (DON1p) and ...
 97-141 1.04e-17

CUE domain found in yeast ubiquitin-binding protein CUE5 (Cue5p), donuts protein 1 (DON1p) and similar proteins; Cue5p, also called coupling of ubiquitin conjugation to ER degradation protein 5, is encoded by the open reading frame (ORF) Yor042. It contains a CUE domain which exhibits weak ubiquitin binding properties. Donuts protein 1 (DON1p) is encoded by the ORF YDR273w. It localizes specifically to the prospore membrane and is expressed exclusively during meiosis. DON1p may function as a unique marker to investigate the defects associated with the impaired function of the meiotic plaque in the mpc- mutants.


Pssm-ID: 270555  Cd Length: 45  Bit Score: 76.14  E-value: 1.04e-17
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 6324615   97 KENPILQELKDAFPNLEEKYIKAVIIASQGVLSPAFNALLFLSDP 141
Cdd:cd14372   1 EQESAIKILKEAFPDVDDKVIKAILIASQGDLEPAFNALLGLTDP 45
CUE smart00546
Domain that may be involved in binding ubiquitin-conjugating enzymes (UBCs); CUE domains also ...
 99-139 3.65e-08

Domain that may be involved in binding ubiquitin-conjugating enzymes (UBCs); CUE domains also occur in two protein of the IL-1 signal transduction pathway, tollip and TAB2. Ponting (Biochem. J.) "Proteins of the Endoplasmic reticulum" (in press)


Pssm-ID: 214715  Cd Length: 43  Bit Score: 49.03  E-value: 3.65e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 6324615      99 NPILQELKDAFPNLEEKYIKAVIIASQGVLSPAFNALLFLS 139
Cdd:smart00546   3 DEALHDLKEMFPNLDEEVIEAVLEANTGNVEATINNLLEGS 43
CUE pfam02845
CUE domain; CUE domains have been shown to bind ubiquitin. It has been suggested that CUE ...
 99-139 8.21e-07

CUE domain; CUE domains have been shown to bind ubiquitin. It has been suggested that CUE domains are related to pfam00627 and this has been confirmed by the structure of the domain. CUE domains also occur in two protein of the IL-1 signal transduction pathway, tollip and TAB2.


Pssm-ID: 427018  Cd Length: 42  Bit Score: 45.16  E-value: 8.21e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 6324615     99 NPILQELKDAFPNLEEKYIKAVIIASQGVLSPAFNALLFLS 139
Cdd:pfam02845   2 EQMLETLKEMFPDLDEEVIRAVLEASNGNVEAAINALLEGS 42
 
Name Accession Description Interval E-value
CUE_Cue5p_like cd14372
CUE domain found in yeast ubiquitin-binding protein CUE5 (Cue5p), donuts protein 1 (DON1p) and ...
 97-141 1.04e-17

CUE domain found in yeast ubiquitin-binding protein CUE5 (Cue5p), donuts protein 1 (DON1p) and similar proteins; Cue5p, also called coupling of ubiquitin conjugation to ER degradation protein 5, is encoded by the open reading frame (ORF) Yor042. It contains a CUE domain which exhibits weak ubiquitin binding properties. Donuts protein 1 (DON1p) is encoded by the ORF YDR273w. It localizes specifically to the prospore membrane and is expressed exclusively during meiosis. DON1p may function as a unique marker to investigate the defects associated with the impaired function of the meiotic plaque in the mpc- mutants.


Pssm-ID: 270555  Cd Length: 45  Bit Score: 76.14  E-value: 1.04e-17
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 6324615   97 KENPILQELKDAFPNLEEKYIKAVIIASQGVLSPAFNALLFLSDP 141
Cdd:cd14372   1 EQESAIKILKEAFPDVDDKVIKAILIASQGDLEPAFNALLGLTDP 45
CUE smart00546
Domain that may be involved in binding ubiquitin-conjugating enzymes (UBCs); CUE domains also ...
 99-139 3.65e-08

Domain that may be involved in binding ubiquitin-conjugating enzymes (UBCs); CUE domains also occur in two protein of the IL-1 signal transduction pathway, tollip and TAB2. Ponting (Biochem. J.) "Proteins of the Endoplasmic reticulum" (in press)


Pssm-ID: 214715  Cd Length: 43  Bit Score: 49.03  E-value: 3.65e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 6324615      99 NPILQELKDAFPNLEEKYIKAVIIASQGVLSPAFNALLFLS 139
Cdd:smart00546   3 DEALHDLKEMFPNLDEEVIEAVLEANTGNVEATINNLLEGS 43
CUE pfam02845
CUE domain; CUE domains have been shown to bind ubiquitin. It has been suggested that CUE ...
 99-139 8.21e-07

CUE domain; CUE domains have been shown to bind ubiquitin. It has been suggested that CUE domains are related to pfam00627 and this has been confirmed by the structure of the domain. CUE domains also occur in two protein of the IL-1 signal transduction pathway, tollip and TAB2.


Pssm-ID: 427018  Cd Length: 42  Bit Score: 45.16  E-value: 8.21e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 6324615     99 NPILQELKDAFPNLEEKYIKAVIIASQGVLSPAFNALLFLS 139
Cdd:pfam02845   2 EQMLETLKEMFPDLDEEVIRAVLEASNGNVEAAINALLEGS 42
CUE cd14279
CUE domain found in ubiquitin-binding CUE proteins; This family includes many coupling of ...
 102-136 2.19e-03

CUE domain found in ubiquitin-binding CUE proteins; This family includes many coupling of ubiquitin conjugation to endoplasmic reticulum degradation (CUE) domain containing proteins that are characterized by an FP and a di-leucine-like sequence and bind to monoubiquitin with varying affinities. Some higher eukaryotic CUE domain proteins do not bind monoubiquitin efficiently, since they carry LP, rather than FP among CUE domains. CUE domains form three-helix bundle structures and are distantly related to the ubiquitin-associated (UBA) domains which are widely occurring ubiquitin-binding motifs found in a broad range of cellular proteins in species ranging from yeast to human. The majority of family members contain one CUE domain, but some family members from fungi harbor two CUE domains.


Pssm-ID: 270465  Cd Length: 38  Bit Score: 35.52  E-value: 2.19e-03
                        10        20        30
                ....*....|....*....|....*....|....*
gi 6324615  102 LQELKDAFPNLEEKYIKAVIIASQGVLSPAFNALL 136
Cdd:cd14279   4 LEQLQEMFPDLDEEVLEDVLEANNGDVEAAIDALL 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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