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Conserved domains on  [gi|6324692|ref|NP_014761|]
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Rtc5p [Saccharomyces cerevisiae S288C]

Protein Classification

TLD domain-containing protein( domain architecture ID 10540210)

TLD domain-containing protein similar to fungal restriction of telomere capping protein 5 (RTC5) and oxidation resistance protein 1 (OXR1) that may be involved in a process influencing telomere capping and in protection from oxidative damage, respectively

PubMed:  26668325|28707022

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TLD pfam07534
TLD; This domain is predicted to be an enzyme and is often found associated with pfam01476. It ...
 355-515 4.07e-23

TLD; This domain is predicted to be an enzyme and is often found associated with pfam01476. It's structure consists of a beta-sandwich surrounded by two helices and two one-turn helices.


:

Pssm-ID: 429519  Cd Length: 139  Bit Score: 95.37  E-value: 4.07e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324692    355 AAEKNPRYRHFLEEFPklkesDQMMDASHLNKRKT-TFAVYIDDPWKVTNKDYFGDLNTRIIEISPRQDIYKVNQKGTIY 433
Cdd:pfam07534   5 TSRDGSSYQTFLEKID-----NKGPTLLIIKDNDGyIFGAFASQPWKVSGKKFYGDGESFLFSLSPQFDPYKWTGKNNAY 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324692    434 FNTigggigigdkqplikpaSKRYI-----PGNVSLTFDSTLEFAVFRNtgyGGSLDPGLLSmerkeenSPYELHFLIQD 508
Cdd:pfam07534  80 FNC-----------------TSDGLgfgggQPKFDLWIDSDLEFGYSRH---CETFGNGQLS-------GSGQERFKIDD 132


                  ....*..
gi 6324692    509 VEVWGCG 515
Cdd:pfam07534 133 VEVWGLG 139
 
Name Accession Description Interval E-value
TLD pfam07534
TLD; This domain is predicted to be an enzyme and is often found associated with pfam01476. It ...
 355-515 4.07e-23

TLD; This domain is predicted to be an enzyme and is often found associated with pfam01476. It's structure consists of a beta-sandwich surrounded by two helices and two one-turn helices.


Pssm-ID: 429519  Cd Length: 139  Bit Score: 95.37  E-value: 4.07e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324692    355 AAEKNPRYRHFLEEFPklkesDQMMDASHLNKRKT-TFAVYIDDPWKVTNKDYFGDLNTRIIEISPRQDIYKVNQKGTIY 433
Cdd:pfam07534   5 TSRDGSSYQTFLEKID-----NKGPTLLIIKDNDGyIFGAFASQPWKVSGKKFYGDGESFLFSLSPQFDPYKWTGKNNAY 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324692    434 FNTigggigigdkqplikpaSKRYI-----PGNVSLTFDSTLEFAVFRNtgyGGSLDPGLLSmerkeenSPYELHFLIQD 508
Cdd:pfam07534  80 FNC-----------------TSDGLgfgggQPKFDLWIDSDLEFGYSRH---CETFGNGQLS-------GSGQERFKIDD 132


                  ....*..
gi 6324692    509 VEVWGCG 515
Cdd:pfam07534 133 VEVWGLG 139
TLDc smart00584
domain in TBC and LysM domain containing proteins;
288-515 4.76e-09

domain in TBC and LysM domain containing proteins;


Pssm-ID: 214733  Cd Length: 165  Bit Score: 55.79  E-value: 4.76e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324692     288 SKVMTPALLAQLSTGLPKELFIHKLQSLYIGRKSGFSMRSLQAKVFKWMAPSILVVSGmritnseeyaaeknpryrhfle 367
Cdd:smart00584   1 SSILSEEILALINSHLPTRAEGYPWTLLYSSSQHGYSLNTLYRKVEGYRPPTLLIIKD---------------------- 58

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324692     368 efpklkesdqmmdashlnKRKTTFAVYIDDPWKVTNKdYFGDLNTRIIEISPRQDIY-KVNQKGTIYFNtigggigiGDK 446
Cdd:smart00584  59 ------------------TDGEVFGAYASQAWRVSDH-FYGTGESFLFQLNPKFVVYdWTGKNKYYYIN--------GTP 111

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6324692     447 QPLIKPASkryiPGNVSLTFDSTLEFAVFRNTGYGGSldpgllsmerkEENSPYELHFLIQDVEVWGCG 515
Cdd:smart00584 112 DSLPIGGG----GGGFGLWIDEDLNHGSSSHCKTFGN-----------PPLSTKQEDFLILDIEVWGFG 165
 
Name Accession Description Interval E-value
TLD pfam07534
TLD; This domain is predicted to be an enzyme and is often found associated with pfam01476. It ...
 355-515 4.07e-23

TLD; This domain is predicted to be an enzyme and is often found associated with pfam01476. It's structure consists of a beta-sandwich surrounded by two helices and two one-turn helices.


Pssm-ID: 429519  Cd Length: 139  Bit Score: 95.37  E-value: 4.07e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324692    355 AAEKNPRYRHFLEEFPklkesDQMMDASHLNKRKT-TFAVYIDDPWKVTNKDYFGDLNTRIIEISPRQDIYKVNQKGTIY 433
Cdd:pfam07534   5 TSRDGSSYQTFLEKID-----NKGPTLLIIKDNDGyIFGAFASQPWKVSGKKFYGDGESFLFSLSPQFDPYKWTGKNNAY 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324692    434 FNTigggigigdkqplikpaSKRYI-----PGNVSLTFDSTLEFAVFRNtgyGGSLDPGLLSmerkeenSPYELHFLIQD 508
Cdd:pfam07534  80 FNC-----------------TSDGLgfgggQPKFDLWIDSDLEFGYSRH---CETFGNGQLS-------GSGQERFKIDD 132


                  ....*..
gi 6324692    509 VEVWGCG 515
Cdd:pfam07534 133 VEVWGLG 139
TLDc smart00584
domain in TBC and LysM domain containing proteins;
288-515 4.76e-09

domain in TBC and LysM domain containing proteins;


Pssm-ID: 214733  Cd Length: 165  Bit Score: 55.79  E-value: 4.76e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324692     288 SKVMTPALLAQLSTGLPKELFIHKLQSLYIGRKSGFSMRSLQAKVFKWMAPSILVVSGmritnseeyaaeknpryrhfle 367
Cdd:smart00584   1 SSILSEEILALINSHLPTRAEGYPWTLLYSSSQHGYSLNTLYRKVEGYRPPTLLIIKD---------------------- 58

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324692     368 efpklkesdqmmdashlnKRKTTFAVYIDDPWKVTNKdYFGDLNTRIIEISPRQDIY-KVNQKGTIYFNtigggigiGDK 446
Cdd:smart00584  59 ------------------TDGEVFGAYASQAWRVSDH-FYGTGESFLFQLNPKFVVYdWTGKNKYYYIN--------GTP 111

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6324692     447 QPLIKPASkryiPGNVSLTFDSTLEFAVFRNTGYGGSldpgllsmerkEENSPYELHFLIQDVEVWGCG 515
Cdd:smart00584 112 DSLPIGGG----GGGFGLWIDEDLNHGSSSHCKTFGN-----------PPLSTKQEDFLILDIEVWGFG 165
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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