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Conserved domains on  [gi|6325071|ref|NP_015138|]
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Uip4p [Saccharomyces cerevisiae S288C]

Protein Classification

glycogen-binding domain-containing protein( domain architecture ID 10120552)

glycogen-binding domain-containing protein similar to Saccharomyces cerevisiae cruciform DNA-recognizing protein 1 and signal transduction protein MDG1, which is involved in G-protein mediated signal transduction and in the regulation of polarized cell growth in pheromone-induced cells

Gene Ontology:  GO:0030246
SCOP:  4007532

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
E_set_AMPKbeta_like_N cd02859
N-terminal Early set domain, a glycogen binding domain, associated with the catalytic domain ...
 1-87 1.73e-11

N-terminal Early set domain, a glycogen binding domain, associated with the catalytic domain of AMP-activated protein kinase beta subunit; E or "early" set domains are associated with the catalytic domain of AMP-activated protein kinase beta subunit glycogen binding domain at the N-terminal end. AMPK is a metabolic stress sensing protein that senses AMP/ATP and has recently been found to act as a glycogen sensor as well. The protein functions as an alpha-beta-gamma heterotrimer. This N-terminal domain is the glycogen binding domain of the beta subunit. This domain is also a member of the CBM48 (Carbohydrate Binding Module 48) family whose members include pullulanase, maltooligosyl trehalose synthase, starch branching enzyme, glycogen branching enzyme, glycogen debranching enzyme, and isoamylase.


:

Pssm-ID: 199889 [Multi-domain]  Cd Length: 80  Bit Score: 59.15  E-value: 1.73e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325071    1 MVTIVFDHPaeDFPELKIAGEFTNW-EGVPMKiNTSSGKWEYKFDESSvtkhndkDKVHFKFIDqNGNWFADDEYPKEVD 79
Cdd:cd02859   1 PVTFRWPGP--GGKEVYVTGSFDNWqQPIPLE-KSGDGEFSATVELPP-------GRYEYKFIV-DGEWVHDPDLPTVTD 69


                ....*...
gi 6325071   80 EHSNENNV 87
Cdd:cd02859  70 EFGNLNNV 77
 
Name Accession Description Interval E-value
E_set_AMPKbeta_like_N cd02859
N-terminal Early set domain, a glycogen binding domain, associated with the catalytic domain ...
 1-87 1.73e-11

N-terminal Early set domain, a glycogen binding domain, associated with the catalytic domain of AMP-activated protein kinase beta subunit; E or "early" set domains are associated with the catalytic domain of AMP-activated protein kinase beta subunit glycogen binding domain at the N-terminal end. AMPK is a metabolic stress sensing protein that senses AMP/ATP and has recently been found to act as a glycogen sensor as well. The protein functions as an alpha-beta-gamma heterotrimer. This N-terminal domain is the glycogen binding domain of the beta subunit. This domain is also a member of the CBM48 (Carbohydrate Binding Module 48) family whose members include pullulanase, maltooligosyl trehalose synthase, starch branching enzyme, glycogen branching enzyme, glycogen debranching enzyme, and isoamylase.


Pssm-ID: 199889 [Multi-domain]  Cd Length: 80  Bit Score: 59.15  E-value: 1.73e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325071    1 MVTIVFDHPaeDFPELKIAGEFTNW-EGVPMKiNTSSGKWEYKFDESSvtkhndkDKVHFKFIDqNGNWFADDEYPKEVD 79
Cdd:cd02859   1 PVTFRWPGP--GGKEVYVTGSFDNWqQPIPLE-KSGDGEFSATVELPP-------GRYEYKFIV-DGEWVHDPDLPTVTD 69


                ....*...
gi 6325071   80 EHSNENNV 87
Cdd:cd02859  70 EFGNLNNV 77
AMPK1_CBM pfam16561
Glycogen recognition site of AMP-activated protein kinase; AMPK1_CBM is a family found in ...
 18-87 1.84e-03

Glycogen recognition site of AMP-activated protein kinase; AMPK1_CBM is a family found in close association with AMPKBI pfam04739. The surface of AMPK1_CBM reveals a carbohydrate-binding pocket.


Pssm-ID: 465176 [Multi-domain]  Cd Length: 85  Bit Score: 36.74  E-value: 1.84e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 6325071     18 IAGEFTNWE-GVPMkiNTSSGKWEYKFDESSVTkHndkdkvHFKFIdQNGNWFADDEYPKEVDEHSNENNV 87
Cdd:pfam16561  16 VTGSFDNWKkKIPL--QKSGGDFTTILDLPPGT-H------QYKFI-VDGEWRHDPDLPTATDDMGNLNNY 76
 
Name Accession Description Interval E-value
E_set_AMPKbeta_like_N cd02859
N-terminal Early set domain, a glycogen binding domain, associated with the catalytic domain ...
 1-87 1.73e-11

N-terminal Early set domain, a glycogen binding domain, associated with the catalytic domain of AMP-activated protein kinase beta subunit; E or "early" set domains are associated with the catalytic domain of AMP-activated protein kinase beta subunit glycogen binding domain at the N-terminal end. AMPK is a metabolic stress sensing protein that senses AMP/ATP and has recently been found to act as a glycogen sensor as well. The protein functions as an alpha-beta-gamma heterotrimer. This N-terminal domain is the glycogen binding domain of the beta subunit. This domain is also a member of the CBM48 (Carbohydrate Binding Module 48) family whose members include pullulanase, maltooligosyl trehalose synthase, starch branching enzyme, glycogen branching enzyme, glycogen debranching enzyme, and isoamylase.


Pssm-ID: 199889 [Multi-domain]  Cd Length: 80  Bit Score: 59.15  E-value: 1.73e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325071    1 MVTIVFDHPaeDFPELKIAGEFTNW-EGVPMKiNTSSGKWEYKFDESSvtkhndkDKVHFKFIDqNGNWFADDEYPKEVD 79
Cdd:cd02859   1 PVTFRWPGP--GGKEVYVTGSFDNWqQPIPLE-KSGDGEFSATVELPP-------GRYEYKFIV-DGEWVHDPDLPTVTD 69


                ....*...
gi 6325071   80 EHSNENNV 87
Cdd:cd02859  70 EFGNLNNV 77
AMPK1_CBM pfam16561
Glycogen recognition site of AMP-activated protein kinase; AMPK1_CBM is a family found in ...
 18-87 1.84e-03

Glycogen recognition site of AMP-activated protein kinase; AMPK1_CBM is a family found in close association with AMPKBI pfam04739. The surface of AMPK1_CBM reveals a carbohydrate-binding pocket.


Pssm-ID: 465176 [Multi-domain]  Cd Length: 85  Bit Score: 36.74  E-value: 1.84e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 6325071     18 IAGEFTNWE-GVPMkiNTSSGKWEYKFDESSVTkHndkdkvHFKFIdQNGNWFADDEYPKEVDEHSNENNV 87
Cdd:pfam16561  16 VTGSFDNWKkKIPL--QKSGGDFTTILDLPPGT-H------QYKFI-VDGEWRHDPDLPTATDDMGNLNNY 76
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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