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Conserved domains on  [gi|6325339|ref|NP_015407|]
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U4/U6-U5 snRNP complex subunit DIB1 [Saccharomyces cerevisiae S288C]

Protein Classification

DIM1 family thioredoxin-like protein( domain architecture ID 10503069)

DIM1 family thioredoxin-like protein similar to Saccharomyces cerevisiae spliceosomal protein DIB1, a component of the U4/U6-U5 tri-snRNP complex that is essential in pre-mRNA splicing, and is also essential for entry into mitosis (G2/M progression) as well as for chromosome segregation during mitosis

CATH:  3.40.30.10
Gene Ontology:  GO:0005681|GO:0005682|GO:0046540
PubMed:  15558583|10049365
SCOP:  3000031

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DIM1 pfam02966
Mitosis protein DIM1;
5-137 1.18e-84

Mitosis protein DIM1;


:

Pssm-ID: 460768  Cd Length: 133  Bit Score: 243.73  E-value: 1.18e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325339      5 LLPQLRTGWHVDQAIVTETKRLVVIRFGRKNDRQCMIMDELLSSIAERVRNFAVIYLCDIDEVSDFDEMYELTDPMTVMF 84
Cdd:pfam02966   1 LLPHLRTGWHVDQAILSEEDKLVVIRFGRDEDPVCMQMDEILYKIAEKVSNFAVIYLVDIDEVPDFNKMYELYDPVTIMF 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 6325339     85 FYHNKHMMCDFGTGNNNKLNFIVDDKQEMIDILETIFRGARKNKGLVVSPYDY 137
Cdd:pfam02966  81 FYNNKHMMIDFGTGDNNKLNFSFEDKQELIDIIETIYRGAMKGKGLVVSPIDY 133
 
Name Accession Description Interval E-value
DIM1 pfam02966
Mitosis protein DIM1;
5-137 1.18e-84

Mitosis protein DIM1;


Pssm-ID: 460768  Cd Length: 133  Bit Score: 243.73  E-value: 1.18e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325339      5 LLPQLRTGWHVDQAIVTETKRLVVIRFGRKNDRQCMIMDELLSSIAERVRNFAVIYLCDIDEVSDFDEMYELTDPMTVMF 84
Cdd:pfam02966   1 LLPHLRTGWHVDQAILSEEDKLVVIRFGRDEDPVCMQMDEILYKIAEKVSNFAVIYLVDIDEVPDFNKMYELYDPVTIMF 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 6325339     85 FYHNKHMMCDFGTGNNNKLNFIVDDKQEMIDILETIFRGARKNKGLVVSPYDY 137
Cdd:pfam02966  81 FYNNKHMMIDFGTGDNNKLNFSFEDKQELIDIIETIYRGAMKGKGLVVSPIDY 133
PLN00410 PLN00410
U5 snRNP protein, DIM1 family; Provisional
 3-140 1.29e-71

U5 snRNP protein, DIM1 family; Provisional


Pssm-ID: 215109  Cd Length: 142  Bit Score: 211.20  E-value: 1.29e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325339     3 SVLLPQLRTGWHVDQAIVTETKRLVVIRFGRKNDRQCMIMDELLSSIAERVRNFAVIYLCDIDEVSDFDEMYELTDPMTV 82
Cdd:PLN00410   2 SYLLPHLHSGWAVDQAILAEEERLVVIRFGHDWDETCMQMDEVLASVAETIKNFAVIYLVDITEVPDFNTMYELYDPCTV 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 6325339    83 MFFYHNKHMMCDFGTGNNNKLNFIVDDKQEMIDILETIFRGARKNKGLVVSPYDYNHK 140
Cdd:PLN00410  82 MFFFRNKHIMIDLGTGNNNKINWALKDKQEFIDIVETVYRGARKGRGLVISPKDYSTK 139
DIM1 cd02954
Dim1 family; Dim1 is also referred to as U5 small nuclear ribonucleoprotein particle (snRNP) ...
 11-124 2.91e-67

Dim1 family; Dim1 is also referred to as U5 small nuclear ribonucleoprotein particle (snRNP)-specific 15kD protein. It is a component of U5 snRNP, which pre-assembles with U4/U6 snRNPs to form a [U4/U6:U5] tri-snRNP complex required for pre-mRNA splicing. Dim1 interacts with multiple splicing-associated proteins, suggesting that it functions at multiple control points in the splicing of pre-mRNA as part of a large spliceosomal complex involving many protein-protein interactions. U5 snRNP contains seven core proteins (common to all snRNPs) and nine U5-specific proteins, one of which is Dim1. Dim1 adopts a thioredoxin fold but does not contain the redox active CXXC motif. It is essential for G2/M phase transition, as a consequence to its role in pre-mRNA splicing.


Pssm-ID: 239252  Cd Length: 114  Bit Score: 199.06  E-value: 2.91e-67
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325339   11 TGWHVDQAIVTETKRLVVIRFGRKNDRQCMIMDELLSSIAERVRNFAVIYLCDIDEVSDFDEMYELTDPMTVMFFYHNKH 90
Cdd:cd02954   1 SGWAVDQAILSEEEKVVVIRFGRDWDPVCMQMDEVLAKIAEDVSNFAVIYLVDIDEVPDFNKMYELYDPPTVMFFFRNKH 80

                        90       100       110
                ....*....|....*....|....*....|....
gi 6325339   91 MMCDFGTGNNNKLNFIVDDKQEMIDILETIFRGA 124
Cdd:cd02954  81 MKIDLGTGNNNKINWVFEDKQEFIDIIETIYRGA 114
 
Name Accession Description Interval E-value
DIM1 pfam02966
Mitosis protein DIM1;
5-137 1.18e-84

Mitosis protein DIM1;


Pssm-ID: 460768  Cd Length: 133  Bit Score: 243.73  E-value: 1.18e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325339      5 LLPQLRTGWHVDQAIVTETKRLVVIRFGRKNDRQCMIMDELLSSIAERVRNFAVIYLCDIDEVSDFDEMYELTDPMTVMF 84
Cdd:pfam02966   1 LLPHLRTGWHVDQAILSEEDKLVVIRFGRDEDPVCMQMDEILYKIAEKVSNFAVIYLVDIDEVPDFNKMYELYDPVTIMF 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 6325339     85 FYHNKHMMCDFGTGNNNKLNFIVDDKQEMIDILETIFRGARKNKGLVVSPYDY 137
Cdd:pfam02966  81 FYNNKHMMIDFGTGDNNKLNFSFEDKQELIDIIETIYRGAMKGKGLVVSPIDY 133
PLN00410 PLN00410
U5 snRNP protein, DIM1 family; Provisional
 3-140 1.29e-71

U5 snRNP protein, DIM1 family; Provisional


Pssm-ID: 215109  Cd Length: 142  Bit Score: 211.20  E-value: 1.29e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325339     3 SVLLPQLRTGWHVDQAIVTETKRLVVIRFGRKNDRQCMIMDELLSSIAERVRNFAVIYLCDIDEVSDFDEMYELTDPMTV 82
Cdd:PLN00410   2 SYLLPHLHSGWAVDQAILAEEERLVVIRFGHDWDETCMQMDEVLASVAETIKNFAVIYLVDITEVPDFNTMYELYDPCTV 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 6325339    83 MFFYHNKHMMCDFGTGNNNKLNFIVDDKQEMIDILETIFRGARKNKGLVVSPYDYNHK 140
Cdd:PLN00410  82 MFFFRNKHIMIDLGTGNNNKINWALKDKQEFIDIVETVYRGARKGRGLVISPKDYSTK 139
DIM1 cd02954
Dim1 family; Dim1 is also referred to as U5 small nuclear ribonucleoprotein particle (snRNP) ...
 11-124 2.91e-67

Dim1 family; Dim1 is also referred to as U5 small nuclear ribonucleoprotein particle (snRNP)-specific 15kD protein. It is a component of U5 snRNP, which pre-assembles with U4/U6 snRNPs to form a [U4/U6:U5] tri-snRNP complex required for pre-mRNA splicing. Dim1 interacts with multiple splicing-associated proteins, suggesting that it functions at multiple control points in the splicing of pre-mRNA as part of a large spliceosomal complex involving many protein-protein interactions. U5 snRNP contains seven core proteins (common to all snRNPs) and nine U5-specific proteins, one of which is Dim1. Dim1 adopts a thioredoxin fold but does not contain the redox active CXXC motif. It is essential for G2/M phase transition, as a consequence to its role in pre-mRNA splicing.


Pssm-ID: 239252  Cd Length: 114  Bit Score: 199.06  E-value: 2.91e-67
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325339   11 TGWHVDQAIVTETKRLVVIRFGRKNDRQCMIMDELLSSIAERVRNFAVIYLCDIDEVSDFDEMYELTDPMTVMFFYHNKH 90
Cdd:cd02954   1 SGWAVDQAILSEEEKVVVIRFGRDWDPVCMQMDEVLAKIAEDVSNFAVIYLVDIDEVPDFNKMYELYDPPTVMFFFRNKH 80

                        90       100       110
                ....*....|....*....|....*....|....
gi 6325339   91 MMCDFGTGNNNKLNFIVDDKQEMIDILETIFRGA 124
Cdd:cd02954  81 MKIDLGTGNNNKINWVFEDKQEFIDIIETIYRGA 114
DLP cd02986
Dim1 family, Dim1-like protein (DLP) subfamily; DLP is a novel protein which shares 38% ...
 15-124 1.27e-23

Dim1 family, Dim1-like protein (DLP) subfamily; DLP is a novel protein which shares 38% sequence identity to Dim1. Like Dim1, it is also implicated in pre-mRNA splicing and cell cycle progression. DLP is located in the nucleus and has been shown to interact with the U5 small nuclear ribonucleoprotein particle (snRNP)-specific 102kD protein (or Prp6). Dim1 protein, also known as U5 snRNP-specific 15kD protein is a component of U5 snRNP, which pre-assembles with U4/U6 snRNPs to form a [U4/U6:U5] tri-snRNP complex required for pre-mRNA splicing. Dim1 adopts a thioredoxin fold but does not contain the redox active CXXC motif.


Pssm-ID: 239284  Cd Length: 114  Bit Score: 88.35  E-value: 1.27e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325339   15 VDQAIVTETKRLVVIRFGRKNDRQCMIMDELLSSIAERVRNFAVIYLCDIDEVSDFDEMYELTDPMTVMFFYHNKHMMCD 94
Cdd:cd02986   5 VDQAIKSTAEKVLVLRFGRDEDAVCLQLDDILSKTSHDLSKMASIYLVDVDKVPVYTQYFDISYIPSTIFFFNGQHMKVD 84

                        90       100       110
                ....*....|....*....|....*....|
gi 6325339   95 FGTGNNNKLNFIVDDKQEMIDILETIFRGA 124
Cdd:cd02986  85 YGSPDHTKFVGSFKTKQDFIDLIEVIYRGA 114
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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