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Conserved domains on  [gi|84370345|ref|NP_032340|]
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5-hydroxytryptamine receptor 5A isoform 1 [Mus musculus]

Protein Classification

G protein-coupled receptor family protein( domain architecture ID 705710)

G protein-coupled receptor family protein is a seven-transmembrane G protein-coupled receptor (7TM-GPCR) family protein which typically transmits an extracellular signal into the cell by the conformational rearrangement of the 7TM helices and by the subsequent binding and activation of an intracellular heterotrimeric G protein; GPCR ligands include light-sensitive compounds, odors, pheromones, hormones, and neurotransmitters

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
7tm_GPCRs super family cl28897
seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...
41-349 7.47e-166

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


The actual alignment was detected with superfamily member cd15328:

Pssm-ID: 475119 [Multi-domain]  Cd Length: 259  Bit Score: 463.27  E-value: 7.47e-166
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  41 VLVLTLLGFLAAATFTWNLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSGRRWQLGRRLCQLWIAC 120
Cdd:cd15328   1 VLVLTLLAMLVVATFLWNLLVLVTILRVRTFHRVPHNLVASMAVSDVLVAALVMPLSLVHELSGRRWQLGRSLCQVWISF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 121 DVLCCTASIWNVTAIALDRYWSITRHLEYTLRTRKRVSNVMILLTWALSTVISLAPLLFGWGETYSEPSEECQVSREPSY 200
Cdd:cd15328  81 DVLCCTASIWNVTAIALDRYWSITRHLEYTLRTRRRISNVMIALTWALSAVISLAPLLFGWGETYSEDSEECQVSQEPSY 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 201 TVFSTVGAFYLPLCVVLFVYWKIYRAAkfrmgsrktnsvspvpeavevknatqhpqmvftvrhatvtfqtegdtwreQKE 280
Cdd:cd15328 161 TVFSTFGAFYLPLCVVLFVYWKIYKAA--------------------------------------------------QKE 190
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 84370345 281 QRAALMVGILIGVFVLCWFPFFVTELISPLCSWDVPAIWKSIFLWLGYSNSFFNPLIYTAFNRSYSSAF 349
Cdd:cd15328 191 KRAALMVGILIGVFVLCWIPFFLTELISPLCSCDIPPIWKSIFLWLGYSNSFFNPLIYTAFNKNYNNAF 259
 
Name Accession Description Interval E-value
7tmA_5-HT5 cd15328
serotonin receptor subtype 5, member of the class A family of seven-transmembrane G ...
41-349 7.47e-166

serotonin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors; 5-HT5 receptor, one of 14 mammalian 5-HT receptors, is activated by the neurotransmitter and peripheral signal mediator serotonin (also known as 5-hydroxytryptamine or 5-HT). The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/0) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320451 [Multi-domain]  Cd Length: 259  Bit Score: 463.27  E-value: 7.47e-166
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  41 VLVLTLLGFLAAATFTWNLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSGRRWQLGRRLCQLWIAC 120
Cdd:cd15328   1 VLVLTLLAMLVVATFLWNLLVLVTILRVRTFHRVPHNLVASMAVSDVLVAALVMPLSLVHELSGRRWQLGRSLCQVWISF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 121 DVLCCTASIWNVTAIALDRYWSITRHLEYTLRTRKRVSNVMILLTWALSTVISLAPLLFGWGETYSEPSEECQVSREPSY 200
Cdd:cd15328  81 DVLCCTASIWNVTAIALDRYWSITRHLEYTLRTRRRISNVMIALTWALSAVISLAPLLFGWGETYSEDSEECQVSQEPSY 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 201 TVFSTVGAFYLPLCVVLFVYWKIYRAAkfrmgsrktnsvspvpeavevknatqhpqmvftvrhatvtfqtegdtwreQKE 280
Cdd:cd15328 161 TVFSTFGAFYLPLCVVLFVYWKIYKAA--------------------------------------------------QKE 190
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 84370345 281 QRAALMVGILIGVFVLCWFPFFVTELISPLCSWDVPAIWKSIFLWLGYSNSFFNPLIYTAFNRSYSSAF 349
Cdd:cd15328 191 KRAALMVGILIGVFVLCWIPFFLTELISPLCSCDIPPIWKSIFLWLGYSNSFFNPLIYTAFNKNYNNAF 259
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
57-338 2.75e-65

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 207.15  E-value: 2.75e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345    57 WNLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSGRRWQLGRRLCQLWIACDVLCCTASIWNVTAIA 136
Cdd:pfam00001   1 GNLLVILVILRNKKLRTPTNIFLLNLAVADLLFSLLTLPFWLVYYLNHGDWPFGSALCKIVGALFVVNGYASILLLTAIS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345   137 LDRYWSITRHLEYTLRTRKRVSNVMILLTWALSTVISLAPLLFGWGETYSEPSE-EC------QVSREPSYTVFSTVGAF 209
Cdd:pfam00001  81 IDRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALLLSLPPLLFGWTLTVPEGNVtVCfidfpeDLSKPVSYTLLISVLGF 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345   210 YLPLCVVLFVYWKIYRAAKFRMGSRKTNSvspvpeavevknatqhpqmvftvrhatvtfqtegdtwREQKEQRAALMVGI 289
Cdd:pfam00001 161 LLPLLVILVCYTLIIRTLRKSASKQKSSE-------------------------------------RTQRRRKALKTLAV 203
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 84370345   290 LIGVFVLCWFPFFVTELISPLC-----SWDVPAIWkSIFLWLGYSNSFFNPLIY 338
Cdd:pfam00001 204 VVVVFILCWLPYHIVNLLDSLAldcelSRLLDKAL-SVTLWLAYVNSCLNPIIY 256
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
82-350 7.28e-05

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 44.00  E-value: 7.28e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345   82 MAISDvLVAVLVMPLSLVHELSgRRWQLGRRLCQLWIACDVLCCTASIWNVTAIALDRYWSITRHLEYTLRTRKRVSNVM 161
Cdd:PHA03087  81 LAVSD-LLFVMTLPFQIYYYIL-FQWSFGEFACKIVSGLYYIGFYNSMNFITVMSVDRYIAIVHPVKSNKINTVKYGYIV 158
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  162 ILLTWALSTVISLaPLLFGWGETYSEPSEECQVSRE-------PSYTVFSTVGAFYLPLCVVLFVYWKIYRAAKfrmGSR 234
Cdd:PHA03087 159 SLVIWIISIIETT-PILFVYTTKKDHETLICCMFYNnktmnwkLFINFEINIIGMLIPLTILLYCYSKILITLK---GIN 234
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  235 KTNsvspvpeavevknatqhpqmvftvrhatvtfqtegdtwreqKEQRAALMVGILIGVFVLCWFPFFVTELISPLCSW- 313
Cdd:PHA03087 235 KSK-----------------------------------------KNKKAIKLVLIIVILFVIFWLPFNVSVFVYSLHILh 273
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 84370345  314 ------DVPAIWKSIFL--WLGYSNSFFNPLIYTAFNRSYSSAFK 350
Cdd:PHA03087 274 fksgckAVKYIQYALHVteIISLSHCCINPLIYAFVSEFFNKHKK 318
 
Name Accession Description Interval E-value
7tmA_5-HT5 cd15328
serotonin receptor subtype 5, member of the class A family of seven-transmembrane G ...
41-349 7.47e-166

serotonin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors; 5-HT5 receptor, one of 14 mammalian 5-HT receptors, is activated by the neurotransmitter and peripheral signal mediator serotonin (also known as 5-hydroxytryptamine or 5-HT). The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/0) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320451 [Multi-domain]  Cd Length: 259  Bit Score: 463.27  E-value: 7.47e-166
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  41 VLVLTLLGFLAAATFTWNLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSGRRWQLGRRLCQLWIAC 120
Cdd:cd15328   1 VLVLTLLAMLVVATFLWNLLVLVTILRVRTFHRVPHNLVASMAVSDVLVAALVMPLSLVHELSGRRWQLGRSLCQVWISF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 121 DVLCCTASIWNVTAIALDRYWSITRHLEYTLRTRKRVSNVMILLTWALSTVISLAPLLFGWGETYSEPSEECQVSREPSY 200
Cdd:cd15328  81 DVLCCTASIWNVTAIALDRYWSITRHLEYTLRTRRRISNVMIALTWALSAVISLAPLLFGWGETYSEDSEECQVSQEPSY 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 201 TVFSTVGAFYLPLCVVLFVYWKIYRAAkfrmgsrktnsvspvpeavevknatqhpqmvftvrhatvtfqtegdtwreQKE 280
Cdd:cd15328 161 TVFSTFGAFYLPLCVVLFVYWKIYKAA--------------------------------------------------QKE 190
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 84370345 281 QRAALMVGILIGVFVLCWFPFFVTELISPLCSWDVPAIWKSIFLWLGYSNSFFNPLIYTAFNRSYSSAF 349
Cdd:cd15328 191 KRAALMVGILIGVFVLCWIPFFLTELISPLCSCDIPPIWKSIFLWLGYSNSFFNPLIYTAFNKNYNNAF 259
7tmA_5-HT1_5_7 cd15064
serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G ...
41-349 2.11e-126

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes serotonin receptor subtypes 1, 5, and 7 that are activated by the neurotransmitter serotonin. The 5-HT1 and 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family. The 5-HT1 receptor subfamily includes 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as 5-HT2C receptor. The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. The 5-HT7 receptor is coupled to Gs, which positively stimulates adenylate cyclase activity, leading to increased intracellular cAMP formation and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320192 [Multi-domain]  Cd Length: 258  Bit Score: 363.19  E-value: 2.11e-126
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  41 VLVLTLLGFLAAATFTWNLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSGRrWQLGRRLCQLWIAC 120
Cdd:cd15064   1 VLISVLLSLIILATILGNALVIAAILLTRKLHTPANYLIASLAVADLLVAVLVMPLSAVYELTGR-WILGQVLCDIWISL 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 121 DVLCCTASIWNVTAIALDRYWSITRHLEYTLRTRKRVSNVMILLTWALSTVISLAPlLFGWGETYSEPSEECQVSREPSY 200
Cdd:cd15064  80 DVTCCTASILHLCVIALDRYWAITDAVEYAHKRTPKRAAVMIALVWTLSICISLPP-LFGWRTPDSEDPSECLISQDIGY 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 201 TVFSTVGAFYLPLCVVLFVYWKIYRAAKfrmgsrktnsvspvpeavevknatqhpqmvftvrhatvtfqtegdtwreqKE 280
Cdd:cd15064 159 TIFSTFGAFYIPLLLMLILYWKIYRAAA--------------------------------------------------RE 188
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 281 QRAALMVGILIGVFVLCWFPFFVTELISPLCS-WDVPAIWKSIFLWLGYSNSFFNPLIYTAFNRSYSSAF 349
Cdd:cd15064 189 RKAAKTLGIILGAFIVCWLPFFLVALIVPLCShCWIPLALKSFFLWLGYFNSLINPLIYTFFNKDFRKAF 258
7tmA_amine_R-like cd14967
amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
42-349 8.19e-82

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320098 [Multi-domain]  Cd Length: 259  Bit Score: 249.79  E-value: 8.19e-82
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  42 LVLTLLGFLAAATFTWNLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSGRrWQLGRRLCQLWIACD 121
Cdd:cd14967   1 LLAVFLSLIILVTVFGNLLVILAVYRNRRLRTVTNYFIVSLAVADLLVALLVMPFSAVYTLLGY-WPFGPVLCRFWIALD 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 122 VLCCTASIWNVTAIALDRYWSITRHLEYTLRTRKRVSNVMILLTWALSTVISLAPLLFGWGETYSEPSE-ECQVSREPSY 200
Cdd:cd14967  80 VLCCTASILNLCAISLDRYLAITRPLRYRQLMTKKRALIMIAAVWVYSLLISLPPLVGWRDETQPSVVDcECEFTPNKIY 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 201 TVFSTVGAFYLPLCVVLFVYWKIYRAAKfrmgsrktnsvspvpeavevknatqhpqmvftvrhatvtfqtegdtwreqKE 280
Cdd:cd14967 160 VLVSSVISFFIPLLIMIVLYARIFRVAR--------------------------------------------------RE 189
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 281 QRAALMVGILIGVFVLCWFPFFVTELISPLCSWD-VPAIWKSIFLWLGYSNSFFNPLIYTAFNRSYSSAF 349
Cdd:cd14967 190 LKAAKTLAIIVGAFLLCWLPFFIIYLVSAFCPPDcVPPILYAVFFWLGYLNSALNPIIYALFNRDFRRAF 259
7tmA_5-HT1A_invertebrates cd15331
serotonin receptor subtype 1A from invertebrates, member of the class A family of ...
41-349 4.39e-81

serotonin receptor subtype 1A from invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320454 [Multi-domain]  Cd Length: 261  Bit Score: 248.04  E-value: 4.39e-81
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  41 VLVLTLLGFLAAATFTWNLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSGRrWQLGRRLCQLWIAC 120
Cdd:cd15331   1 VLTSIILGLLILATIIGNVFVIAAILLERSLQGVSNYLILSLAVADLMVAVLVMPLSAVYEVSQH-WFLGPEVCDMWISM 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 121 DVLCCTASIWNVTAIALDRYWSITRhLEYTLRTRKRVSNVMILLTWALSTVISLAPlLFGWGE----TYSEPSEECQVSR 196
Cdd:cd15331  80 DVLCCTASILHLVAIALDRYWAVTN-IDYIRRRTAKRILIMIAVVWFVSLIISIAP-LFGWKDeddlDRVLKTGVCLISQ 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 197 EPSYTVFSTVGAFYLPLCVVLFVYWKIYRAAKfrmgsrktnsvspvpeavevknatqhpqmvftvrhatvtfqtegdtwr 276
Cdd:cd15331 158 DYGYTIFSTVGAFYVPLLLMIIIYWKIYQAAK------------------------------------------------ 189
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 84370345 277 eqKEQRAALMVGILIGVFVLCWFPFFVTELISPLC-SWDVPAIWKSIFLWLGYSNSFFNPLIYTAFNRSYSSAF 349
Cdd:cd15331 190 --RERKAARTLAIITGAFVVCWLPFFLVALVMPFCgAWQISRFLESFFLWLGYFNSLLNPIIYTIFSPDFRGAF 261
7tmA_5-HT7 cd15329
serotonin receptor subtype 7, member of the class A family of seven-transmembrane G ...
41-349 1.36e-80

serotonin receptor subtype 7, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT7 receptor, one of 14 mammalian serotonin receptors, is a member of the class A of GPCRs and is activated by the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). 5-HT7 receptor mainly couples to Gs protein, which positively stimulates adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. 5-HT7 receptor is expressed in various human tissues, mainly in the brain, the lower gastrointestinal tract and in vital blood vessels including the coronary artery. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320452 [Multi-domain]  Cd Length: 260  Bit Score: 246.80  E-value: 1.36e-80
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  41 VLVLTLLGFLAAATFTWNLLVLATILKVRTFhRVPHN-LVASMAISDVLVAVLVMPLSLVHELSGRrWQLGRRLCQLWIA 119
Cdd:cd15329   1 VLIGIVLLIIILGTVVGNALVIIAVCLVKKL-RTPSNyLIVSLAVSDLLVALLVMPLAIIYELSGY-WPFGEILCDVWIS 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 120 CDVLCCTASIWNVTAIALDRYWSITRHLEY-TLRTRKRVSnVMILLTWALSTVISLAPlLFGWGETYSEPSeECQVSREP 198
Cdd:cd15329  79 FDVLLCTASILNLCAISVDRYLVITRPLTYaVKRTPKRMA-LMIAIVWLLSALISIPP-LFGWKNKVNDPG-VCQVSQDF 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 199 SYTVFSTVGAFYLPLCVVLFVYWKIYRAAKfrmgsrktnsvspvpeavevknatqhpqmvftvrhatvtfqtegdtwreq 278
Cdd:cd15329 156 GYQIYATFGAFYIPLIVMLVLYYKIYRAAK-------------------------------------------------- 185
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 84370345 279 KEQRAALMVGILIGVFVLCWFPFFVTELISPLCSWD----VPAIWKSIFLWLGYSNSFFNPLIYTAFNRSYSSAF 349
Cdd:cd15329 186 SERKAIKTLGIIMGAFTLCWLPFFILALLRPFLKPIkcscIPLWLSRLFLWLGYANSFLNPIIYAKFNREFRTPF 260
7tmA_alpha2_AR cd15059
alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G ...
41-349 2.70e-68

alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320187 [Multi-domain]  Cd Length: 261  Bit Score: 215.28  E-value: 2.70e-68
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  41 VLVLTLLGFLAAATFTWNLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSGRrWQLGRRLCQLWIAC 120
Cdd:cd15059   1 VAISSIVSVVILLIIVGNVLVIVAVLTSRKLRAPQNWFLVSLAVADILVGLLIMPFSLVNELMGY-WYFGSVWCEIWLAL 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 121 DVLCCTASIWNVTAIALDRYWSITRHLEYTL-RTRKRVSnVMILLTWALSTVISLAPlLFGWGETYSEPSEE--CQVSRE 197
Cdd:cd15059  80 DVLFCTASIVNLCAISLDRYWSVTQAVEYNLkRTPRRAK-AMIAAVWIISAVISLPP-LFGWKDEQPWHGAEpqCELSDD 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 198 PSYTVFSTVGAFYLPLCVVLFVYWKIYRAAKfrmgsrktnsvspvpeavevknatqhpqmvftvrhatvtfqtegdtwre 277
Cdd:cd15059 158 PGYVLFSSIGSFYIPLLIMIIVYARIYRAAK------------------------------------------------- 188
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 84370345 278 QKEQRAALMVGILIGVFVLCWFPFFVTELISPLCSW-DVPAIWKSIFLWLGYSNSFFNPLIYTAFNRSYSSAF 349
Cdd:cd15059 189 RKERRFTLVLGVVMGAFVLCWLPFFFTYPLVVVCKTcGVPELLFKFFFWLGYCNSALNPVIYTIFNKDFRRAF 261
7tmA_tyramine_octopamine_R-like cd15060
tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G ...
41-349 1.16e-65

tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine/octopamine receptors and similar proteins found in insects and other invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320188 [Multi-domain]  Cd Length: 260  Bit Score: 208.44  E-value: 1.16e-65
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  41 VLVLTLLGFLAAATFTWNLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSGRrWQLGRRLCQLWIAC 120
Cdd:cd15060   1 VVTTILLSVIIAFTIVGNILVILSVFTYRPLRIVQNFFIVSLAVADLAVAIFVLPLNVAYFLLGK-WLFGIHLCQMWLTC 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 121 DVLCCTASIWNVTAIALDRYWSITRHLEYTL-RTRKRVsNVMILLTWALSTVISLAPlLFGWG--ETYSEPSEECQVSRE 197
Cdd:cd15060  80 DILCCTASILNLCAIALDRYWAIHDPINYAQkRTLKRV-LLMIVVVWALSALISVPP-LIGWNdwPENFTETTPCTLTEE 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 198 PSYTVFSTVGAFYLPLCVVLFVYWKIYRAAkfrmgsrktnsvspvpeavevknatqhpqmvftvrhatvtfqtegdtwre 277
Cdd:cd15060 158 KGYVIYSSSGSFFIPLLIMTIVYVKIFIAT-------------------------------------------------- 187
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 84370345 278 QKEQRAALMVGILIGVFVLCWFPFFVTELISPLCSWDVP-AIWKSIFLWLGYSNSFFNPLIYTAFNRSYSSAF 349
Cdd:cd15060 188 SKERRAARTLGIIMGVFVVCWLPFFLMYVILPFCETCSPsAKVVNFITWLGYVNSALNPVIYTIFNLDFRRAF 260
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
57-338 2.75e-65

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 207.15  E-value: 2.75e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345    57 WNLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSGRRWQLGRRLCQLWIACDVLCCTASIWNVTAIA 136
Cdd:pfam00001   1 GNLLVILVILRNKKLRTPTNIFLLNLAVADLLFSLLTLPFWLVYYLNHGDWPFGSALCKIVGALFVVNGYASILLLTAIS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345   137 LDRYWSITRHLEYTLRTRKRVSNVMILLTWALSTVISLAPLLFGWGETYSEPSE-EC------QVSREPSYTVFSTVGAF 209
Cdd:pfam00001  81 IDRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALLLSLPPLLFGWTLTVPEGNVtVCfidfpeDLSKPVSYTLLISVLGF 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345   210 YLPLCVVLFVYWKIYRAAKFRMGSRKTNSvspvpeavevknatqhpqmvftvrhatvtfqtegdtwREQKEQRAALMVGI 289
Cdd:pfam00001 161 LLPLLVILVCYTLIIRTLRKSASKQKSSE-------------------------------------RTQRRRKALKTLAV 203
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 84370345   290 LIGVFVLCWFPFFVTELISPLC-----SWDVPAIWkSIFLWLGYSNSFFNPLIY 338
Cdd:pfam00001 204 VVVVFILCWLPYHIVNLLDSLAldcelSRLLDKAL-SVTLWLAYVNSCLNPIIY 256
7tmA_tyramine_R-like cd15061
tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
46-349 3.23e-65

tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine-specific receptors and similar proteins found in insects and other invertebrates. These tyramine receptors form a distinct receptor family that is phylogenetically different from the other tyramine/octopamine receptors which also found in invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320189 [Multi-domain]  Cd Length: 256  Bit Score: 207.21  E-value: 3.23e-65
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  46 LLGFLAAATFTWNLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSGRrWQLGRRLCQLWIACDVLCC 125
Cdd:cd15061   5 FLILAIIFTIFGNLLVILAVATTRRLRTITNCYIVSLATADLLVGVLVLPLAIIRQLLGY-WPLGSHLCDFWISLDVLLC 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 126 TASIWNVTAIALDRYWSITRHLEYTLRTRKRVSNVMILLTWALSTVISLAPlLFGWGETYSEPSEECQVSREPSYTVFST 205
Cdd:cd15061  84 TASILNLCCISLDRYFAITYPLKYRTKRSRRLAITMILAVWVISLLITSPP-LVGPSWHGRRGLGSCYYTYDKGYRIYSS 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 206 VGAFYLPLCVVLFVYWKIYRAAKfrmgsrktnsvspvpeavevknatqhpqmvftvrhatvtfqtegdtwreqKEQRAAL 285
Cdd:cd15061 163 MGSFFLPLLLMLFVYLRIFRVIA--------------------------------------------------KERKTAK 192
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 84370345 286 MVGILIGVFVLCWFPFFVTELISPLCSWDVPAIWKSIFLWLGYSNSFFNPLIYTAFNRSYSSAF 349
Cdd:cd15061 193 TLAIVVGCFIVCWLPFFIMYLIEPFCDCQFSEALSTAFTWLGYFNSVINPFIYAFYNKDFRRAF 256
7tmA_Ap5-HTB1-like cd15065
serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of ...
42-349 1.17e-64

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes Aplysia californica serotonin receptors Ap5-HTB1 and Ap5-HTB2, and similar proteins from bilateria including insects, mollusks, annelids, and worms. Ap5-HTB1 is one of the several different receptors for 5-hydroxytryptamine (5HT, serotonin). In Aplysia, serotonin plays important roles in a variety of behavioral and physiological processes mediated by the central nervous system. These include circadian clock, feeding, locomotor movement, cognition and memory, synaptic growth and synaptic plasticity. Both Ap5-HTB1 and Ap5-HTB2 receptors are coupled to G-proteins that stimulate phospholipase C, leading to the activation of phosphoinositide metabolism. Ap5-HTB1 is expressed in the reproductive system, whereas Ap5-HTB2 is expressed in the central nervous system.


Pssm-ID: 320193 [Multi-domain]  Cd Length: 300  Bit Score: 207.20  E-value: 1.17e-64
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  42 LVLTLLGFLAAATFTWNLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSGRrWQLGRRLCQLWIACD 121
Cdd:cd15065   1 LIGIFLSLIIVLAIFGNVLVCLAIFTDRRLRKKSNLFIVSLAVADLLVALLVMTFAVVNDLLGY-WLFGETFCNIWISFD 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 122 VLCCTASIWNVTAIALDRYWSITRHLEYTLRTRKRVSNVMILLTWALSTVISLAPLLFGWGETYSEPSEE---------- 191
Cdd:cd15065  80 VMCSTASILNLCAISLDRYIHIKKPLKYERWMTTRRALVVIASVWILSALISFLPIHLGWHRLSQDEIKGlnhasnpkps 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 192 CQVSREPSYTVFSTVGAFYLPLCVVLFVYWKIYRAAKFRMGSRKTNSvspVPEAVEVKNATQHPQMVFTVRHATvtfqte 271
Cdd:cd15065 160 CALDLNPTYAVVSSLISFYIPCLVMLLIYSRLYLYARKHVVNIKSQK---LPSESGSKFQVPSLSSKHNNQGVS------ 230
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 84370345 272 gdtwreqkEQRAALMVGILIGVFVLCWFPFFVTELISPLCSWDVPAIWKSIFLWLGYSNSFFNPLIYTAFNRSYSSAF 349
Cdd:cd15065 231 --------DHKAAVTLGIIMGVFLICWLPFFIINIIAAFCKTCIPPKCFKILTWLGYFNSCLNPIIYSIFNSEFRRAF 300
7tmA_Dop1R2-like cd15067
dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the ...
42-349 1.56e-64

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled dopamine 1-like receptor 2 is expressed in Drosophila heads and it shows significant sequence similarity with vertebrate and invertebrate dopamine receptors. Although the Drosophila Dop1R2 receptor does not cluster into the D1-like structural group, it does show pharmacological properties similar to D1-like receptors. As shown in vertebrate D1-like receptors, agonist stimulation of Dop1R2 activates adenylyl cyclase to increase cAMP levels and also generates a calcium signal through stimulation of phospholipase C.


Pssm-ID: 320195 [Multi-domain]  Cd Length: 262  Bit Score: 205.67  E-value: 1.56e-64
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  42 LVLTLLGFLAAATFTWNLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSGRRWQLGRRLCQLWIACD 121
Cdd:cd15067   1 LLGVVLSLFCLVTVAGNLLVILAVLRERYLRTVTNYFIVSLAVADLLVGSIVMPFSILHEMTGGYWLFGRDWCDVWHSFD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 122 VLCCTASIWNVTAIALDRYWSITRHLEYTLRTRKRVSNVMILLTWALSTVISLaPLLFGWGET--YSEPSEECQVSREPS 199
Cdd:cd15067  81 VLASTASILNLCVISLDRYWAITDPISYPSRMTKRRALIMIALVWICSALISF-PAIAWWRAVdpGPSPPNQCLFTDDSG 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 200 YTVFSTVGAFYLPLCVVLFVYWKIYRAAkfrmgsrktnsvspvpeavevknatqhpqmvftvrhatvtfqtegdtwreQK 279
Cdd:cd15067 160 YLIFSSCVSFYIPLVVMLFTYYRIYRAA--------------------------------------------------AK 189
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 84370345 280 EQRAALMVGILIGVFVLCWFPFFVTELISPLCSWDV---PAIWKSIFLWLGYSNSFFNPLIYTAFNRSYSSAF 349
Cdd:cd15067 190 EQKAAKTLGIVMGVFILCWLPFFVTNILIGFCPSNCvsnPDILFPLVTWLGYINSGMNPIIYACSSRDFRRAF 262
7tmA_5-HT1B_1D cd15333
serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G ...
37-349 4.43e-61

serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320455 [Multi-domain]  Cd Length: 265  Bit Score: 196.94  E-value: 4.43e-61
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  37 SAFRVLVLTLLGFLAAATFTWNLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSGRrWQLGRRLCQL 116
Cdd:cd15333   1 LGLKISLAVLLALITLATTLSNAFVIATIYLTRKLHTPANYLIASLAVTDLLVSILVMPISIVYTVTGT-WTLGQVVCDI 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 117 WIACDVLCCTASIWNVTAIALDRYWSITRHLEYTLRTRKRVSNVMILLTWALSTVISLAPLLFGWGETYSEPSEECQVSR 196
Cdd:cd15333  80 WLSSDITCCTASILHLCVIALDRYWAITDAVEYSKKRTPKRAAVMIALVWVISISISLPPFFWRQAKAEEEVSECVVNTD 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 197 EPSYTVFSTVGAFYLPLCVVLFVYWKIYRAAKFRmgsrktnsvspvpeavevknatqhpqmvftvrhatvtfqtegdtwr 276
Cdd:cd15333 160 HILYTVYSTVGAFYIPTLLLIALYGRIYVEARAR---------------------------------------------- 193
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 84370345 277 eqkEQRAALMVGILIGVFVLCWFPFFVTELISPLC---SWDVPAIWkSIFLWLGYSNSFFNPLIYTAFNRSYSSAF 349
Cdd:cd15333 194 ---ERKATKTLGIILGAFIVCWLPFFIISLVLPICkdaCWFHLAIF-DFFTWLGYLNSLINPIIYTMSNEDFKQAF 265
7tmA_5-HT1A_vertebrates cd15330
serotonin receptor subtype 1A from vertebrates, member of the class A family of ...
41-349 1.50e-60

serotonin receptor subtype 1A from vertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320453 [Multi-domain]  Cd Length: 260  Bit Score: 195.20  E-value: 1.50e-60
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  41 VLVLTLLGFLAAATFTWNLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSGRrWQLGRRLCQLWIAC 120
Cdd:cd15330   1 IITSLFLGTLILCAIFGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNK-WTLGQVTCDLFIAL 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 121 DVLCCTASIWNVTAIALDRYWSITRHLEYTLRTRKRVSNVMILLTWALSTVISLAPLLfGW--GETYSEPsEECQVSREP 198
Cdd:cd15330  80 DVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAVLISLTWLIGFSISIPPML-GWrtPEDRSDP-DACTISKDP 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 199 SYTVFSTVGAFYLPLCVVLFVYWKIYRAAKfrmgsrktnsvspvpeavevknatqhpqmvftvrhatvtfqtegdtwreq 278
Cdd:cd15330 158 GYTIYSTFGAFYIPLILMLVLYGRIFKAAA-------------------------------------------------- 187
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 84370345 279 KEQRAALMVGILIGVFVLCWFPFFVTELISPLCSWD--VPAIWKSIFLWLGYSNSFFNPLIYTAFNRSYSSAF 349
Cdd:cd15330 188 RERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESTchMPELLGAIINWLGYSNSLLNPIIYAYFNKDFQSAF 260
7tmA_D2-like_dopamine_R cd15053
D2-like dopamine receptors, member of the class A family of seven-transmembrane G ...
58-349 1.03e-58

D2-like dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320181 [Multi-domain]  Cd Length: 263  Bit Score: 190.63  E-value: 1.03e-58
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  58 NLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSGRRWQLGRRLCQLWIACDVLCCTASIWNVTAIAL 137
Cdd:cd15053  18 NVLVIMSVFRERSLQTATNYFIVSLAVADLLVAILVMPFAVYVEVNGGKWYLGPILCDIYIAMDVMCSTASIFNLCAISI 97
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 138 DRYWSITRHLEYTLRTRKRVSNVMILLTWALSTVISLaPLLFGWGETYSEPSEECQVSrEPSYTVFSTVGAFYLPLCVVL 217
Cdd:cd15053  98 DRYIAVTQPIKYARQKNSKRVLLTIAIVWVVSAAIAC-PLLFGLNNVPYRDPEECRFY-NPDFIIYSSISSFYIPCIVML 175
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 218 FVYWKIYRAAKfrmgsrktnsvspvpeavevknatqhpqmvftvrhatvtfqtegdtwreqKEQRAALMVGILIGVFVLC 297
Cdd:cd15053 176 LLYYRIFRALR--------------------------------------------------REKKATKTLAIVLGVFLFC 205
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 84370345 298 WFPFFVTELISPLC------SWDVPAIWKSIFLWLGYSNSFFNPLIYTAFNRSYSSAF 349
Cdd:cd15053 206 WLPFFTLNILNAICpklqnqSCHVGPALFSLTTWLGYVNSFLNPIIYTIFNIEFRKAF 263
7tmA_5-HT1F cd15334
serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G ...
41-350 9.20e-58

serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320456 [Multi-domain]  Cd Length: 259  Bit Score: 188.23  E-value: 9.20e-58
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  41 VLVLTLLGFLAAATFTWNLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHeLSGRRWQLGRRLCQLWIAC 120
Cdd:cd15334   1 ILISLTLSILALMTTAINSLVITAIIVTRKLHHPANYLICSLAVTDFLVAVLVMPFSIMY-IVKETWIMGQVVCDIWLSV 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 121 DVLCCTASIWNVTAIALDRYWSITRHLEYTLRTRKRVSNVMILLTWALSTVISLAPLLfgWGETYSEPSEECQVSREP-S 199
Cdd:cd15334  80 DITCCTCSILHLSAIALDRYRAITDAVEYARKRTPKHAGIMIAVVWIISIFISMPPLF--WRHQTTSREDECIIKHDHiV 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 200 YTVFSTVGAFYLPLCVVLFVYWKIYRAAkfrmgsrktnsvspvpeavevknatqhpqmvftvrhatvtfqtegdtwreQK 279
Cdd:cd15334 158 FTIYSTFGAFYIPLALILILYYKIYRAA--------------------------------------------------TR 187
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 84370345 280 EQRAALMVGILIGVFVLCWFPFFVTELISPLCSWDVPAIWKSIFL-WLGYSNSFFNPLIYTAFNRSYSSAFK 350
Cdd:cd15334 188 ERKAATTLGLILGAFVICWLPFFVKEVIVNTCDSCYISEEMSNFLtWLGYINSLINPLIYTIFNEDFKKAFQ 259
7tmA_D1-like_dopamine_R cd15057
D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G ...
41-349 1.13e-57

D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320185 [Multi-domain]  Cd Length: 299  Bit Score: 189.18  E-value: 1.13e-57
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  41 VLVLTLLGFLAAATFTWNLLVLATILKVRTFHR-VPHNLVASMAISDVLVAVLVMPLSLVHELSGRrWQLGRrLCQLWIA 119
Cdd:cd15057   1 IITGCILYLLVLLTLLGNALVIAAVLRFRHLRSkVTNYFIVSLAVSDLLVAILVMPWAAVNEVAGY-WPFGS-FCDVWVS 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 120 CDVLCCTASIWNVTAIALDRYWSITRHLEYTLRTRKRVSNVMILLTWALSTVISLAPLLFGW--------GETYSEPSEE 191
Cdd:cd15057  79 FDIMCSTASILNLCVISVDRYWAISSPFRYERRMTRRRAFIMIAVAWTLSALISFIPVQLGWhraddtseALALYADPCQ 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 192 CQVSREPSYTVFSTVGAFYLPLCVVLFVYWKIYRAAKfrmgsRKTNSVSPVPEAVevkNATQHPqmvftVRHATVTFqte 271
Cdd:cd15057 159 CDSSLNRTYAISSSLISFYIPVAIMIVTYTRIYRIAR-----RQIRRIAALERAA---QESTNP-----DSSLRSSL--- 222
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 272 gdtwreQKEQRAALMVGILIGVFVLCWFPFFVTELISPLCSWD------VPAIWKSIFLWLGYSNSFFNPLIYtAFNRSY 345
Cdd:cd15057 223 ------RRETKALKTLSIIMGVFVCCWLPFFILNCVLPFCDLRtaqfpcVPDTTFIVFVWLGWANSSLNPIIY-AFNADF 295

                ....
gi 84370345 346 SSAF 349
Cdd:cd15057 296 RKAF 299
7tmA_Histamine_H2R cd15051
histamine subtype H2 receptor, member of the class A family of seven-transmembrane G ...
41-349 2.22e-57

histamine subtype H2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H2R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H2R subtype selectively interacts with the G(s)-type G protein that activates adenylate cyclase, leading to increased cAMP production and activation of Protein Kinase A. H2R is found in various tissues such as the brain, stomach, and heart. Its most prominent role is in histamine-induced gastric acid secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320179 [Multi-domain]  Cd Length: 287  Bit Score: 187.92  E-value: 2.22e-57
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  41 VLVLTLLGFLAAATFTWNLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSGRrWQLGRRLCQLWIAC 120
Cdd:cd15051   1 IVLGVVLAVIILLTVIGNVLVCLAVAVNRRLRNLTNYFIVSLAVTDLLLGLLVLPFSAIYELRGE-WPLGPVFCNIYISL 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 121 DVLCCTASIWNVTAIALDRYWSITRHLEYTLRTRKRVSNVMILLTWALSTVISLAPLLFGWGETYS-----EPSEECQVS 195
Cdd:cd15051  80 DVMLCTASILNLFAISLDRYLAITAPLRYPSRVTPRRVAIALAAIWVVSLAVSFLPIHLGWNTPDGrvqngDTPNQCRFE 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 196 REPSYTVFSTVGAFYLPLCVVLFVYWKIYRAAkfRMGSRKTNSVSPVPEAVEVKNAtqhpqmvFTVRhatvtfqtegdtw 275
Cdd:cd15051 160 LNPPYVLLVAIGTFYLPLLIMCGVYLRIFRIA--REQAKRINALTPASTANSSKSA-------ATAR------------- 217
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 84370345 276 reqkEQRAALMVGILIGVFVLCWFPFFVTELISPLCSWDVPAIWKSIFLWLGYSNSFFNPLIYTAFNRSYSSAF 349
Cdd:cd15051 218 ----EHKATVTLAAVLGAFIICWFPYFTYFTYRGLCGDNINETALSVVLWLGYANSALNPILYAFLNRDFRRAF 287
7tmA_5-HT1E cd15335
serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G ...
41-349 9.49e-56

serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320457 [Multi-domain]  Cd Length: 258  Bit Score: 182.82  E-value: 9.49e-56
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  41 VLVLTLLGFLAAATFTWNLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHeLSGRRWQLGRRLCQLWIAC 120
Cdd:cd15335   1 MLIVLTLALITILTTVLNSAVIAAICTTKKLHQPANYLICSLAVTDFLVAVLVMPLSITY-IVMDTWTLGYFICEIWLSV 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 121 DVLCCTASIWNVTAIALDRYWSITRHLEYTLRTRKRVSNVMILLTWALSTVISLAPlLFGWGETYSEPSEECQVSREP-S 199
Cdd:cd15335  80 DMTCCTCSILHLCVIALDRYWAITDAIEYARKRTAKRAGLMILTVWTISIFISIPP-LFWRNHHDANIPSQCIIQHDHvI 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 200 YTVFSTVGAFYLPLCVVLFVYWKIYRAAkfrmgsrktnsvspvpeavevknatqhpqmvftvrhatvtfqtegdtwreQK 279
Cdd:cd15335 159 YTIYSTFGAFYIPLTLILILYYRIYHAA--------------------------------------------------SR 188
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 280 EQRAALMVGILIGVFVLCWFPFFVTELISPLCSWDVPAIWKSIFLWLGYSNSFFNPLIYTAFNRSYSSAF 349
Cdd:cd15335 189 ERKAARILGLILGAFILSWLPFFIKELIVGLSVMTVSPEVADFLTWLGYVNSLVNPLLYTSFNEDFKLAF 258
7tmA_alpha1_AR cd15062
alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G ...
41-349 9.66e-55

alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320190 [Multi-domain]  Cd Length: 261  Bit Score: 180.38  E-value: 9.66e-55
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  41 VLVLTLLGFLAAATFTWNLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSGRrWQLGRRLCQLWIAC 120
Cdd:cd15062   1 IVVGVALGAFILFAIGGNLLVILSVACNRHLRTPTHYFIVNLAVADLLLSFTVLPFSATLEVLGY-WAFGRIFCDVWAAV 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 121 DVLCCTASIWNVTAIALDRYWSITRHLEYTLRTRKRVSNVMILLTWALSTVISLAPLLfGWGETYSEPSEECQVSREPSY 200
Cdd:cd15062  80 DVLCCTASIMSLCVISVDRYIGVRYPLNYPTIVTARRATVALLIVWVLSLVISIGPLL-GWKEPAPADEQACGVNEEPGY 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 201 TVFSTVGAFYLPLCVVLFVYWKIYRAA-KFRmgsrktnsvspvpeavevknatqhpqmvftvrhatvtfqtegdtwreqK 279
Cdd:cd15062 159 VLFSSLGSFYLPLAIILVMYCRVYVVAfKFS------------------------------------------------R 190
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 84370345 280 EQRAALMVGILIGVFVLCWFPFFVTELISPLCSWDVP--AIWKSIFlWLGYSNSFFNPLIYTAFNRSYSSAF 349
Cdd:cd15062 191 EKKAAKTLGIVVGAFVLCWFPFFVVLPLGSLFSTLKPpePVFKVVF-WLGYFNSCLNPIIYPCSSREFKRAF 261
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
44-342 1.22e-54

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 180.56  E-value: 1.22e-54
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  44 LTLLGFLAAATFTWNLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSGRrWQLGRRLCQLWIACDVL 123
Cdd:cd00637   2 AVLYILIFVVGLVGNLLVILVILRNRRLRTVTNYFILNLAVADLLVGLLVIPFSLVSLLLGR-WWFGDALCKLLGFLQSV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 124 CCTASIWNVTAIALDRYWSITRHLEYTLRTRKRVSNVMILLTWALSTVISLAPLLFGWGETYSEPSEEC----QVSREPS 199
Cdd:cd00637  81 SLLASILTLTAISVDRYLAIVHPLRYRRRFTRRRAKLLIALIWLLSLLLALPPLLGWGVYDYGGYCCCClcwpDLTLSKA 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 200 YTVFSTVGAFYLPLCVVLFVYWKIYRAAKFRMGSRKTNSVSPVPEAvevknatqhpqmvftvrhatvtfqtegdtwREQK 279
Cdd:cd00637 161 YTIFLFVLLFLLPLLVIIVCYVRIFRKLRRHRRRIRSSSSNSSRRR------------------------------RRRR 210
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 84370345 280 EQRAALMVGILIGVFVLCWFPFFVTELISPLC--SWDVPAIWKSIFLWLGYSNSFFNPLIYTAFN 342
Cdd:cd00637 211 ERKVTKTLLIVVVVFLLCWLPYFILLLLDVFGpdPSPLPRILYFLALLLAYLNSAINPIIYAFFN 275
7tmA_Beta_AR cd15058
beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane ...
41-338 1.03e-53

beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta adrenergic receptor (beta adrenoceptor), also known as beta AR, is activated by hormone adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate, as well as pulmonary physiology. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of beta-ARs can lead to cardiac dysfunction such as arrhythmias or heart failure. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320186 [Multi-domain]  Cd Length: 305  Bit Score: 179.18  E-value: 1.03e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  41 VLVLTLLGFLAAATFTWNLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSGRrWQLGRRLCQLWIAC 120
Cdd:cd15058   1 PGLLLLLALIILAIVVGNLLVIIAIARTSRLQTMTNIFITSLACADLVMGLLVVPLGATIVVTGK-WQLGNFWCELWTSV 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 121 DVLCCTASIWNVTAIALDRYWSITRHLEYTLRTRKRVSNVMILLTWALSTVISLAPLLFGW--------GETYSEPsEEC 192
Cdd:cd15058  80 DVLCVTASIETLCVIAVDRYIAITRPLRYQVLLTKRRARVIVCVVWIVSALVSFVPIMNQWwrandpeaNDCYQDP-TCC 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 193 QVSREPSYTVFSTVGAFYLPLCVVLFVYWKIYRAAKFRMGSRKTNSVSPVPEAVEVKNATQHPQMVFTVRHATVTFqteg 272
Cdd:cd15058 159 DFRTNMAYAIASSVVSFYIPLLIMIFVYARVFLIATRQLQLIDKRRLRFQSECPAPQTTSPEGKRSSGRRPSRLTV---- 234
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 84370345 273 dtwreQKEQRAALMVGILIGVFVLCWFPFFVTELISPLCSwDVPAIWKSIFL-WLGYSNSFFNPLIY 338
Cdd:cd15058 235 -----VKEHKALKTLGIIMGTFTLCWLPFFIANIINVFNR-NLPPGEVFLLLnWLGYINSGLNPIIY 295
7tmA_alpha2C_AR cd15323
alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G ...
46-349 1.84e-53

alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320446 [Multi-domain]  Cd Length: 261  Bit Score: 177.05  E-value: 1.84e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  46 LLGFLAAATFTWNLLVLATILKVRTFhRVPHNL-VASMAISDVLVAVLVMPLSLVHELSGRrWQLGRRLCQLWIACDVLC 124
Cdd:cd15323   6 VVGFLIVFTIVGNVLVVIAVLTSRAL-RAPQNLfLVSLASADILVATLVMPFSLANELMGY-WYFGQVWCNIYLALDVLF 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 125 CTASIWNVTAIALDRYWSITRHLEYTLRTRKRVSNVMILLTWALSTVISLAPLLFGWGETYSEPSEECQVSREPSYTVFS 204
Cdd:cd15323  84 CTSSIVHLCAISLDRYWSVTQAVEYNLKRTPRRVKAIIVTVWLISAVISFPPLISMYRDPEGDVYPQCKLNDETWYILSS 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 205 TVGAFYLPLCVVLFVYWKIYRAAKFRmgsrktnsvspvpeavevknatqhpqmvftvrhatvtfqtegdtwreqkEQRAA 284
Cdd:cd15323 164 CIGSFFAPCLIMILVYIRIYRVAKAR-------------------------------------------------EKRFT 194
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 84370345 285 LMVGILIGVFVLCWFPFFVTELISPLC--SWDVPAIWKSIFLWLGYSNSFFNPLIYTAFNRSYSSAF 349
Cdd:cd15323 195 FVLAVVMGVFVVCWFPFFFSYSLYGICreACEVPEPLFKFFFWIGYCNSSLNPVIYTIFNQDFRRSF 261
7tmA_alpha2A_AR cd15322
alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
41-349 4.52e-53

alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320445 [Multi-domain]  Cd Length: 259  Bit Score: 175.90  E-value: 4.52e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  41 VLVLTLLGFLAAATFTWNLLVLATILKVRTFhRVPHNL-VASMAISDVLVAVLVMPLSLVHELSGRrWQLGRRLCQLWIA 119
Cdd:cd15322   1 LTLIILVGLLMLLTVFGNVLVIIAVFTSRAL-KAPQNLfLVSLASADILVATLVIPFSLANEVMGY-WYFGKVWCEIYLA 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 120 CDVLCCTASIWNVTAIALDRYWSITRHLEYTLRTRKRVSNVMILLTWALSTVISLAPLLFGWGETYSEPSEECQVSREPS 199
Cdd:cd15322  79 LDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLITIEKKSGQPEGPICKINDEKW 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 200 YTVFSTVGAFYLPLCVVLFVYWKIYRAAKFRmgsrktnsvspvpeavevknatqhpqmvftvrhatvtfqtegdtwreqk 279
Cdd:cd15322 159 YIISSCIGSFFAPCLIMVLVYIRIYQIAKNR------------------------------------------------- 189
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 280 EQRAALMVGILIGVFVLCWFPFFVTELISPLCSWDVPAIWKSIFLWLGYSNSFFNPLIYTAFNRSYSSAF 349
Cdd:cd15322 190 EKRFTFVLAVVIGVFVICWFPFFFTYTLTAVCDCSVPETLFKFFFWFGYCNSSLNPVIYTIFNHDFRRAF 259
7tmA_alpha2B_AR cd15321
alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
45-349 1.37e-52

alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320444 [Multi-domain]  Cd Length: 268  Bit Score: 175.11  E-value: 1.37e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  45 TLLGFLAAATFTWNLLVLATILKVRTFhRVPHNL-VASMAISDVLVAVLVMPLSLVHELSGRrWQLGRRLCQLWIACDVL 123
Cdd:cd15321  11 AAITFLILFTIFGNVLVIIAVLTSRSL-RAPQNLfLVSLAAADILVATLIIPFSLANELMGY-WYFRKTWCEIYLALDVL 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 124 CCTASIWNVTAIALDRYWSITRHLEY-TLRTRKRVsNVMILLTWALSTVISLAPLLF-GWGETYSEPSEECQVSREPSYT 201
Cdd:cd15321  89 FCTSSIVHLCAISLDRYWSVSRAIEYnSKRTPRRI-KCIILIVWLIAAVISLPPLIYkGKQKDEQGGLPQCKLNEEAWYI 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 202 VFSTVGAFYLPLCVVLFVYWKIYRAAKFRmgsrktnsvspvpeavevknatqhpqmvftvrhatvtfqtegdtwreqkEQ 281
Cdd:cd15321 168 LSSSIGSFFAPCLIMILVYLRIYLIAKNR-------------------------------------------------EK 198
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 282 RAALMVGILIGVFVLCWFPFFVTELISPLC--SWDVPAIWKSIFLWLGYSNSFFNPLIYTAFNRSYSSAF 349
Cdd:cd15321 199 RFTFVLAVVIGVFVLCWFPFFFSYSLGAICpeLCKVPHSLFQFFFWIGYCNSSLNPVIYTIFNQDFRRAF 268
7tmA_DmOct-betaAR-like cd15066
Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar ...
39-349 4.61e-52

Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar receptors in bilateria; member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila beta-adrenergic-like octopamine receptors and similar proteins. The biogenic amine octopamine is the invertebrate equivalent of vertebrate adrenergic neurotransmitters and exerts its effects through different G protein-coupled receptor types. Insect octopamine receptors are involved in the modulation of carbohydrate metabolism, muscular tension, cognition and memory. The activation of octopamine receptors mediating these actions leads to an increase in adenylate cyclase activity, thereby increasing cAMP levels. In Drosophila melanogaster, three subgroups have been classified on the basis of their structural homology and functional equivalents with vertebrate beta-adrenergic receptors: DmOctBeta1R, DmOctBeta2R, and DmOctBeta3R.


Pssm-ID: 320194 [Multi-domain]  Cd Length: 265  Bit Score: 173.72  E-value: 4.61e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  39 FRVLVLTLLgfLAAATFTwNLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSGRrWQLGRRLCQLWI 118
Cdd:cd15066   1 LKGFAMTLI--ILAAIFG-NLLVIISVMRHRKLRVITNYFVVSLAMADMLVALCAMTFNASVEITGR-WMFGYFMCDVWN 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 119 ACDVLCCTASIWNVTAIALDRYWSITRHLEYTLRTRKRVSNVMILLTWALSTVISLAPLLFGWGET------YSEPSEEC 192
Cdd:cd15066  77 SLDVYFSTASILHLCCISVDRYYAIVQPLEYPSKMTKRRVAIMLANVWISPALISFLPIFLGWYTTeehlqyRKTHPDQC 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 193 QVSREPSYTVFSTVGAFYLPLCVVLFVYWKIYRAAKfrmgsrktnsvspvpeavevknatqhpqmvftvrhatvtfqteg 272
Cdd:cd15066 157 EFVVNKIYALISSSVSFWIPCIVMIFTYYRIYLEAK-------------------------------------------- 192
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 84370345 273 dtwreqKEQRAALMVGILIGVFVLCWFPFFVTELISPLCSWD--VPAIWKSIFLWLGYSNSFFNPLIYTAFNRSYSSAF 349
Cdd:cd15066 193 ------REHKAAKTLGIIMGAFILCWLPFFLWYVTTTLCGDAcpYPPILVSILFWIGYFNSTLNPLIYAYFNRDFREAF 265
7tmA_TAARs cd15055
trace amine-associated receptors, member of the class A family of seven-transmembrane G ...
41-349 1.99e-50

trace amine-associated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptors (TAARs) are a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320183 [Multi-domain]  Cd Length: 285  Bit Score: 170.04  E-value: 1.99e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  41 VLVLTLLGFLAAATFTWNLLVLATILKVRTFHrVPHN-LVASMAISDVLVAVLVMPLSLVhELSGRRWQLGRRLCQLWIA 119
Cdd:cd15055   1 VLLYIVLSSISLLTVLGNLLVIISISHFKQLH-TPTNlLLLSLAVADFLVGLLVMPFSMI-RSIETCWYFGDTFCKLHSS 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 120 CDVLCCTASIWNVTAIALDRYWSITRHLEYTLRTRKRVSNVMILLTWALSTVISLAPLLFGWGET----YSEPSEECQVS 195
Cdd:cd15055  79 LDYILTSASIFNLVLIAIDRYVAVCDPLLYPTKITIRRVKICICLCWFVSALYSSVLLYDNLNQPglirYNSCYGECVVV 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 196 REPSYTVFSTVGAFYLPLCVVLFVYWKIYRAAKFRMgsRKTNSvspvpeaVEVKNATQHPQMVFTVRhatvtfqtegdtw 275
Cdd:cd15055 159 VNFIWGVVDLVLTFILPCTVMIVLYMRIFVVARSQA--RAIRS-------HTAQVSLEGSSKKVSKK------------- 216
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 84370345 276 reqKEQRAALMVGILIGVFVLCWFPFFVTELISPLCSwdVPAIWKSIFLWLGYSNSFFNPLIYTAFNRSYSSAF 349
Cdd:cd15055 217 ---SERKAAKTLGIVVGVFLLCWLPYYIVSLVDPYIS--TPSSVFDVLIWLGYFNSCLNPLIYALFYPWFRKAL 285
7tmA_alpha1A_AR cd15325
alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
41-349 2.04e-50

alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320448 [Multi-domain]  Cd Length: 261  Bit Score: 169.30  E-value: 2.04e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  41 VLVLTLLGFLAAATFTWNLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSGRrWQLGRRLCQLWIAC 120
Cdd:cd15325   1 IVLGVILGGFILFGVLGNILVILSVACHRHLQTVTHYFIVNLAVADLLLTSTVLPFSAIFEILGY-WAFGRVFCNIWAAV 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 121 DVLCCTASIWNVTAIALDRYWSITRHLEYTLRTRKRVSNVMILLTWALSTVISLAPlLFGWGETYSEPSEECQVSREPSY 200
Cdd:cd15325  80 DVLCCTASIMSLCIISIDRYIGVSYPLRYPSIMTERRGLLALLCVWVLSLVISIGP-LFGWKEPAPEDETICQITEEPGY 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 201 TVFSTVGAFYLPLCVVLFVYWKIYRAA-KFrmgsrktnsvspvpeavevknatqhpqmvftvrhatvtfqtegdtwreQK 279
Cdd:cd15325 159 ALFSALGSFYLPLAIILVMYCRVYVVAlKF------------------------------------------------SR 190
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 84370345 280 EQRAALMVGILIGVFVLCWFPFFvteLISPLCSWDVPA-----IWKSIFlWLGYSNSFFNPLIYTAFNRSYSSAF 349
Cdd:cd15325 191 EKKAAKTLGIVVGCFVLCWLPFF---LVMPIGSIFPAYkpsdtVFKITF-WLGYFNSCINPIIYPCSSQEFKKAF 261
7tmA_TAAR1 cd15314
trace amine-associated receptor 1 and similar receptors, member of the class A family of ...
41-349 2.09e-50

trace amine-associated receptor 1 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 1 (TAAR1) is one of the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. TAAR1 is coupled to the Gs protein, which leads to activation of adenylate cyclase, and is thought to play functional role in the regulation of brain monoamines. TAAR1 is also shown to be activated by psychoactive compounds such as Ecstasy (MDMA), amphetamine and LSD. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320438 [Multi-domain]  Cd Length: 282  Bit Score: 169.73  E-value: 2.09e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  41 VLVLTLLGFLAAATFTWNLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSGRrWQLGRRLCQLWIAC 120
Cdd:cd15314   1 VLLYIFLGLISLVTVCGNLLVIISIAHFKQLHTPTNYLILSLAVADLLVGGLVMPPSMVRSVETC-WYFGDLFCKIHSSF 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 121 DVLCCTASIWNVTAIALDRYWSITRHLEYTLRTRKRVSNVMILLTWALSTVISLAPLLF-----GWGETYSEPSEECQVS 195
Cdd:cd15314  80 DITLCTASILNLCFISIDRYYAVCQPLLYRSKITVRVVLVMILISWSVSALVGFGIIFLelnikGIYYNHVACEGGCLVF 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 196 REPSYTVFSTVGAFYLPLCVVLFVYWKIYRAAKfrmgsRKTNSVspvpeavevknatqhpQMVFTVRHATVTfqtegdtw 275
Cdd:cd15314 160 FSKVSSVVGSVFSFYIPAVIMLCIYLKIFLVAQ-----RQARSI----------------QSARTKSGASSS-------- 210
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 84370345 276 reQKEQRAALMVGILIGVFVLCWFPFFVTELISPLCSWDVPAIWKSIFLWLGYSNSFFNPLIYTAFNRSYSSAF 349
Cdd:cd15314 211 --KMERKATKTLAIVMGVFLLCWTPFFLCNIIDPFINYSIPPVLIEVLNWLGYSNSTLNPFIYAFFYSWFRKAF 282
7tmA_alpha1B_AR cd15326
alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
41-349 7.77e-50

alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320449 [Multi-domain]  Cd Length: 261  Bit Score: 167.76  E-value: 7.77e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  41 VLVLTLLGFLAAATFTWNLLVLATILKVRTFhRVPHN-LVASMAISDVLVAVLVMPLSLVHELSGRrWQLGRRLCQLWIA 119
Cdd:cd15326   1 ILLGLVLGAFILFAIVGNILVILSVVCNRHL-RIPTNyFIVNLAIADLLLSFTVLPFSATLEILGY-WVFGRIFCDIWAA 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 120 CDVLCCTASIWNVTAIALDRYWSITRHLEY-TLRTRKRvSNVMILLTWALSTVISLAPLLfGWGETYSEPSEECQVSREP 198
Cdd:cd15326  79 VDVLCCTASILSLCAISIDRYIGVRHSLQYpTIVTRKR-AILALLGVWVLSTVISIGPLL-GWKEPAPPDDKVCEITEEP 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 199 SYTVFSTVGAFYLPLCVVLFVYWKIYRAA-KFrmgsrktnsvspvpeavevknatqhpqmvftvrhatvtfqtegdtwre 277
Cdd:cd15326 157 FYALFSSLGSFYIPLIVILVMYCRVYIVAlKF------------------------------------------------ 188
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 84370345 278 QKEQRAALMVGILIGVFVLCWFPFFVTELISPLCSWDVP--AIWKSIFlWLGYSNSFFNPLIYTAFNRSYSSAF 349
Cdd:cd15326 189 SREKKAAKTLGIVVGMFILCWLPFFIALPLGSLFSHLKPpeTLFKIIF-WLGYFNSCLNPIIYPCSSKEFKRAF 261
7tmA_5-HT4 cd15056
serotonin receptor subtype 4, member of the class A family of seven-transmembrane G ...
35-349 1.15e-49

serotonin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT4 subtype is a member of the serotonin receptor family that belongs to the class A G protein-coupled receptors, and binds the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT4 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. 5-HT4 receptor-specific agonists have been shown to enhance learning and memory in animal studies. Moreover, hippocampal 5-HT4 receptor expression has been reported to be inversely correlated with memory performance in humans. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320184 [Multi-domain]  Cd Length: 294  Bit Score: 168.44  E-value: 1.15e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  35 FLSAfrVLVLTLLGflaaatftwNLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSGRrWQLGRRLC 114
Cdd:cd15056   6 FLSL--VILLTILG---------NLLVIVAVCTDRQLRKKTNYFVVSLAVADLLVAVLVMPFGAIELVNNR-WIYGETFC 73
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 115 QLWIACDVLCCTASIWNVTAIALDRYWSITRHLEYTLRTRKRVSnVMILLTWALSTVISLAPLLFGWGETYSEPSEECQV 194
Cdd:cd15056  74 LVRTSLDVLLTTASIMHLCCIALDRYYAICCQPLVYKMTPLRVA-VMLGGCWVIPTFISFLPIMQGWNHIGIEDLIAFNC 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 195 SREPSYTVF----------STVgAFYLPLCVVLFVYWKIYRAAKFRMgsRKTNSVspvpEAVEVKNATQHPQMVFTVRHa 264
Cdd:cd15056 153 ASGSTSCVFmvnkpfaiicSTV-AFYIPALLMVLAYYRIYVAAREQA--HQIRSL----QRAGSSNHEADQHRNSRMRT- 224
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 265 tvtfqtegdtwreqkEQRAALMVGILIGVFVLCWFPFFVTELISPLCSWDVPAIWKSIFLWLGYSNSFFNPLIYTAFNRS 344
Cdd:cd15056 225 ---------------ETKAAKTLGIIMGCFCVCWAPFFVTNIVDPFIGYRVPYLLWTAFLWLGYINSGLNPFLYAFFNKS 289

                ....*
gi 84370345 345 YSSAF 349
Cdd:cd15056 290 FRRAF 294
7tmA_Octopamine_R cd15063
octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G ...
41-349 2.43e-48

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor for octopamine (OA), which functions as a neurotransmitter, neurohormone, and neuromodulator in invertebrate nervous system. Octopamine (also known as beta, 4-dihydroxyphenethylamine) is an endogenous trace amine that is highly similar to norepinephrine, but lacks a hydroxyl group, and has effects on the adrenergic and dopaminergic nervous systems. Based on the pharmacological and signaling profiles, the octopamine receptors can be classified into at least two groups: OA1 receptors elevate intracellular calcium levels in muscle, whereas OA2 receptors activate adenylate cyclase and increase cAMP production.


Pssm-ID: 320191 [Multi-domain]  Cd Length: 266  Bit Score: 163.82  E-value: 2.43e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  41 VLVLTLLGFLAAATFTWNLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSgRRWQLGRRLCQLWIAC 120
Cdd:cd15063   1 LISLLVLTFLNVLVVLGNLLVIAAVLCSRKLRTVTNLFIVSLACADLLVGTLVLPFSAVNEVL-DVWIFGHTWCQIWLAV 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 121 DVLCCTASIWNVTAIALDRYWSITRHLEYTLRTRKRVSNVMILLTWALSTVISLAPlLFGWGE---------TYSEPSEE 191
Cdd:cd15063  80 DVWMCTASILNLCAISLDRYLAITRPIRYPSLMSTKRAKCLIAGVWVLSFVICFPP-LVGWNDgkdgimdysGSSSLPCT 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 192 CQVSREPSYTVFSTVGAFYLPLCVVLFVYWKIYRAAKfrmgsrktnsvspvpeavevknatqhpqmvftvrhatvtfqte 271
Cdd:cd15063 159 CELTNGRGYVIYSALGSFYIPMLVMLFFYFRIYRAAR------------------------------------------- 195
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 84370345 272 gdtwreqKEQRAALMVGILIGVFVLCWFPFFVTELISPLCSWDVPAIWKSIFLWLGYSNSFFNPLIYTAFNRSYSSAF 349
Cdd:cd15063 196 -------METKAAKTVAIIVGCFIFCWLPFFTVYLVRAFCEDCIPPLLFSVFFWLGYCNSALNPCIYALFSRDFRFAF 266
7tmA_D1A_dopamine_R cd15320
D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...
40-349 2.78e-48

D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320443 [Multi-domain]  Cd Length: 319  Bit Score: 165.56  E-value: 2.78e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  40 RVLVLTLLGFLAAATFTWNLLVLATILKVRTFH-RVPHNLVASMAISDVLVAVLVMPLSLVHELSGRrWQLGRrLCQLWI 118
Cdd:cd15320   1 RVLTGCFLSVLILSTLLGNTLVCAAVIRFRHLRsKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGF-WPFGS-FCNIWV 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 119 ACDVLCCTASIWNVTAIALDRYWSITRHLEYTLRTRKRVSNVMILLTWALSTVISLAPLLFGW------------GETYS 186
Cdd:cd15320  79 AFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKVAFIMISVAWTLSVLISFIPVQLNWhkakptsfldlnASLRD 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 187 EPSEECQVSREPSYTVFSTVGAFYLPLCVVLFVYWKIYRAAKFRMgsRKTNSVSPVPEAVEVKNATQHPQMVFTVRHATV 266
Cdd:cd15320 159 LTMDNCDSSLNRTYAISSSLISFYIPVAIMIVTYTRIYRIAQKQI--RRISALERAAVHAKNCQNSTGNRGSGDCQQPES 236
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 267 TFQTEGdtwreQKEQRAALMVGILIGVFVLCWFPFFVTELISPLC---SWDVPAIWKS---IFLWLGYSNSFFNPLIYtA 340
Cdd:cd15320 237 SFKMSF-----KRETKVLKTLSVIMGVFVCCWLPFFILNCMVPFCkptSTEPFCISSTtfdVFVWFGWANSSLNPIIY-A 310

                ....*....
gi 84370345 341 FNRSYSSAF 349
Cdd:cd15320 311 FNADFRKAF 319
7tmA_5-HT2 cd15052
serotonin receptor subtype 2, member of the class A family of seven-transmembrane G ...
41-349 1.13e-47

serotonin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320180 [Multi-domain]  Cd Length: 262  Bit Score: 162.10  E-value: 1.13e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  41 VLVLTLLGFLAAATftwNLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSGRRWQLGRRLCQLWIAC 120
Cdd:cd15052   4 ALLLLLLVIATIGG---NILVCLAISLEKRLQNVTNYFLMSLAIADLLVGLLVMPLSILTELFGGVWPLPLVLCLLWVTL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 121 DVLCCTASIWNVTAIALDRYWSITRHLEYTLRTRKRVSNVMILLTWALSTVISLAPLLFGWGETYSEPSEECQVSREPSY 200
Cdd:cd15052  81 DVLFCTASIMHLCTISLDRYMAIRYPLRTRRNKSRTTVFLKIAIVWLISIGISSPIPVLGIIDTTNVLNNGTCVLFNPNF 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 201 TVFSTVGAFYLPLCVVLFVYWKIYRAAKfrmgsrktnsvspvpeavevknatqhpqmvftvrhatvtfqtegdtwreqKE 280
Cdd:cd15052 161 VIYGSIVAFFIPLLIMVVTYALTIRLLS--------------------------------------------------NE 190
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 84370345 281 QRAALMVGILIGVFVLCWFPFFVTELISPLC---SWDVPAIWKSIFLWLGYSNSFFNPLIYTAFNRSYSSAF 349
Cdd:cd15052 191 QKASKVLGIVFAVFVICWCPFFITNILTGLCeecNCRISPWLLSVFVWLGYVSSTINPIIYTIFNKTFRRAF 262
7tmA_D3_dopamine_R cd15310
D3 subtype of the D2-like family of dopamine receptors, member of the class A family of ...
58-349 2.15e-46

D3 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320436 [Multi-domain]  Cd Length: 259  Bit Score: 158.59  E-value: 2.15e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  58 NLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSGRRWQLGRRLCQLWIACDVLCCTASIWNVTAIAL 137
Cdd:cd15310  18 NVLVCMAVLRERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISI 97
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 138 DRYWSITRHLEYTLRT----RKRVSnVMILLTWALSTVISlAPLLFGWGETySEPSeECQVSrEPSYTVFSTVGAFYLPL 213
Cdd:cd15310  98 DRYTAVVMPVHYQHGTgqssCRRVS-LMITAVWVLAFAVS-CPLLFGFNTT-GDPT-VCSIS-NPDFVIYSSVVSFYLPF 172
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 214 CVVLFVYWKIYraakfrmgsrktnsvspvpeavevknatqhpqmVFTVRhatvtfqtegdtwreqkEQRAALMVGILIGV 293
Cdd:cd15310 173 GVTLLVYVRIY---------------------------------VVLLR-----------------EKKATQMLAIVLGA 202
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 84370345 294 FVLCWFPFFVTELISPLC-SWDVPAIWKSIFLWLGYSNSFFNPLIYTAFNRSYSSAF 349
Cdd:cd15310 203 FIVCWLPFFLTHILNTHCqACHVPPELYSATTWLGYVNSALNPVIYTTFNIEFRRAF 259
7tmA_D1B_dopamine_R cd15319
D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...
45-349 2.98e-46

D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320442 [Multi-domain]  Cd Length: 317  Bit Score: 160.12  E-value: 2.98e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  45 TLLGFLAAATFTWNLLVLATILKVRTFH-RVPHNLVASMAISDVLVAVLVMPLSLVHELSGRrWQLGRrLCQLWIACDVL 123
Cdd:cd15319   5 CLLSLLILWTLLGNILVCAAVVRFRHLRsKVTNIFIVSLAVSDLFVALLVMPWKAVAEVAGY-WPFGA-FCDVWVAFDIM 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 124 CCTASIWNVTAIALDRYWSITRHLEYTLRTRKRVSNVMILLTWALSTVISLAPLLFGWGETYSE-------------PSE 190
Cdd:cd15319  83 CSTASILNLCVISVDRYWAISSPFRYERKMTQRVALVMISVAWTLSVLISFIPVQLNWHKDSGDdwvglhnssisrqVEE 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 191 ECQVSREPSYTVFSTVGAFYLPLCVVLFVYWKIYRAAKFRMgsRKTNSvspvpeaveVKNATQHPQMVFTVR---HATVT 267
Cdd:cd15319 163 NCDSSLNRTYAISSSLISFYIPVAIMIVTYTRIYRIAQIQI--RRISS---------LERAAEHAQSCRSNRidcHHHTS 231
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 268 FQTEgdtwrEQKEQRAALMVGILIGVFVLCWFPFFVTELISPLCSWD-------VPAIWKS---IFLWLGYSNSFFNPLI 337
Cdd:cd15319 232 LRTS-----IKKETKVLKTLSVIMGVFVCCWLPFFILNCMVPFCDRPpadpdagLPCVSETtfdVFVWFGWANSSLNPII 306
                       330
                ....*....|..
gi 84370345 338 YtAFNRSYSSAF 349
Cdd:cd15319 307 Y-AFNADFRKVF 317
7tmA_alpha-2D_AR cd15324
alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
41-349 6.72e-45

alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320447 [Multi-domain]  Cd Length: 256  Bit Score: 154.64  E-value: 6.72e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  41 VLVLTLLGFLAAATFTWNLLVLATILKVRTFhRVPHNL-VASMAISDVLVAVLVMPLSLVHELSGRrWQLGRRLCQLWIA 119
Cdd:cd15324   1 ALIVLVVVVIILVTIVGNVLVVVAVFTSRAL-RAPQNLfLVSLASADILVATLVIPFSLANEVMGY-WYFGSTWCAFYLA 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 120 CDVLCCTASIWNVTAIALDRYWSITRHLEYTLRTRKRVSNVMILLTWALSTVISLAPLLFGwgetySEPSEECQVSREPS 199
Cdd:cd15324  79 LDVLFCTSSIVHLCAISLDRYWSVTKAVSYNLKRTPKRIKRMIAVVWVISAVISFPPLLMT-----KHDEWECLLNDETW 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 200 YTVFSTVGAFYLPLCVVLFVYWKIYRAAKFRmgsrktnsvspvpeavevknatqhpqmvftvrhatvtfqtegdtwreqk 279
Cdd:cd15324 154 YILSSCTVSFFAPGLIMILVYCKIYRVAKMR------------------------------------------------- 184
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 84370345 280 EQRAALMVGILIGVFVLCWFPFFVTELISPLC--SWDVPAIWKSIFLWLGYSNSFFNPLIYTAFNRSYSSAF 349
Cdd:cd15324 185 EKRFTFVLAVVMGVFVLCWFPFFFTYSLHAVCrkRCGIPDALFNLFFWIGYCNSSVNPIIYTIFNRDFRKAF 256
7tmA_alpha1D_AR cd15327
alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
58-349 2.88e-44

alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320450 [Multi-domain]  Cd Length: 261  Bit Score: 153.14  E-value: 2.88e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  58 NLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSGRrWQLGRRLCQLWIACDVLCCTASIWNVTAIAL 137
Cdd:cd15327  18 NILVILSVACNRHLQTVTNYFIVNLAIADLLLSTTVLPFSATLEVLGF-WAFGRVFCDIWAAVDVLCCTASILSLCVISV 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 138 DRYWSITRHLEYTLRTRKRVSNVMILLTWALSTVISLAPLLfGWGETYSEPSEECQVSREPSYTVFSTVGAFYLPLCVVL 217
Cdd:cd15327  97 DRYVGVKHSLKYPTIMTERKAGVILVLLWVSSMVISIGPLL-GWKEPPPPDESICSITEEPGYALFSSLFSFYLPLMVIL 175
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 218 FVYWKIYRAA-KFrmgsrktnsvspvpeavevknatqhpqmvftvrhatvtfqtegdtwreQKEQRAALMVGILIGVFVL 296
Cdd:cd15327 176 VMYFRVYVVAlKF------------------------------------------------SREKKAAKTLAIVVGVFIL 207
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 84370345 297 CWFPFFvteLISPLCSWdVPA------IWKSIFlWLGYSNSFFNPLIYTAFNRSYSSAF 349
Cdd:cd15327 208 CWFPFF---FVLPLGSF-FPAlkpsemVFKVIF-WLGYFNSCVNPIIYPCSSKEFKRAF 261
7tmA_mAChR cd15049
muscarinic acetylcholine receptor subfamily, member of the class A family of ...
41-349 2.92e-44

muscarinic acetylcholine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341322 [Multi-domain]  Cd Length: 262  Bit Score: 153.24  E-value: 2.92e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  41 VLVLTLLGFLAAATFTWNLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSGRrWQLGRRLCQLWIAC 120
Cdd:cd15049   1 VLICIATGSLSLVTVGGNILVILSFRVNRQLRTVNNYFLLSLACADLIIGLVSMNLYTVYLVMGY-WPLGPLLCDLWLAL 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 121 DVLCCTASIWNVTAIALDRYWSITRHLEYTLRTRKRVSNVMILLTWALStVISLAPLLFGWGETYSE---PSEECQVS-- 195
Cdd:cd15049  80 DYVASNASVMNLLLISFDRYFSVTRPLTYRAKRTPKRAILMIALAWVIS-FVLWAPAILGWQYFVGErtvPDGQCYIQfl 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 196 REPSYTVFSTVGAFYLPLCVVLFVYWKIYRAAKfrmgsrktnsvspvpeavevknatqhpqmvftvrhatvtfqtegdtw 275
Cdd:cd15049 159 DDPAITFGTAIAAFYLPVLVMTILYWRIYRETA----------------------------------------------- 191
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 84370345 276 reqKEQRAALMVGILIGVFVLCWFPFFVTELISPLCSWDVPAIWKSIFLWLGYSNSFFNPLIYTAFNRSYSSAF 349
Cdd:cd15049 192 ---RERKAARTLSAILLAFIITWTPYNILVLVSTFCAKCIPDTLWSFGYWLCYINSTINPFCYALCNKTFRKTF 262
7tmA_Histamine_H1R cd15050
histamine subtype H1 receptor, member of the class A family of seven-transmembrane G ...
41-349 5.59e-44

histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H1R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). H1R selectively interacts with the G(q)-type G protein that activates phospholipase C and the phosphatidylinositol pathway. Antihistamines, a widely used anti-allergy medication, act on the H1 subtype and produce drowsiness as a side effect. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320178 [Multi-domain]  Cd Length: 263  Bit Score: 152.58  E-value: 5.59e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  41 VLVLTLLGFLAAATFTWNLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSGRrWQLGRRLCQLWIAC 120
Cdd:cd15050   1 APLGIALSTISLITVILNLLVLYAVRTERKLHTVGNLYIVSLSVADLIVGAVVMPLNIVYLLESK-WILGRPVCLFWLSM 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 121 DVLCCTASIWNVTAIALDRYWSITRHLEYTLRTRKRVSNVMILLTWALS---TVISLAPLLFGWGETYSEPSEECQV--S 195
Cdd:cd15050  80 DYVASTASIFSLFILCIDRYRSVQQPLKYLKYRTKTRASLMISGAWLLSflwVIPILGWHHFARGGERVVLEDKCETdfH 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 196 REPSYTVFSTVGAFYLPLCVVLFVYWKIYRAAKfrmgsrktnsvspvpeavevknatqhpqmvftvrhatvtfqtegdtw 275
Cdd:cd15050 160 DVTWFKVLTAILNFYIPSLLMLWFYAKIFKAVN----------------------------------------------- 192
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 84370345 276 reqKEQRAALMVGILIGVFVLCWFPFFVTELISPLCSWDVPAIWKSIFLWLGYSNSFFNPLIYTAFNRSYSSAF 349
Cdd:cd15050 193 ---RERKAAKQLGFIMAAFILCWIPYFILFMVIAFCKNCCNENLHMFTIWLGYINSTLNPFIYPLCNENFKKTF 263
7tmA_Beta3_AR cd15959
beta-3 adrenergic receptors (adrenoceptors), member of the class A family of ...
42-338 1.87e-42

beta-3 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-3 adrenergic receptor (beta-3 adrenoceptor), also known as beta-3 AR, is activated by adrenaline and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320625 [Multi-domain]  Cd Length: 302  Bit Score: 149.67  E-value: 1.87e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  42 LVLTLLGFLAAATFTWNLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSGRrWQLGRRLCQLWIACD 121
Cdd:cd15959   2 LAGALLSLAILVIVGGNLLVIVAIAKTPRLQTMTNVFVTSLACADLVMGLLVVPPGATILLTGH-WPLGTTVCELWTSVD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 122 VLCCTASIWNVTAIALDRYWSITRHLEYTLRTRKRVSNVMILLTWALSTVISLAPLL-FGWGETYSEPSEECQ------- 193
Cdd:cd15959  81 VLCVTASIETLCAIAVDRYLAITNPLRYEALVTKRRARTAVCLVWAISAAISFLPIMnQWWRDGADEEAQRCYdnprccd 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 194 -VSREPsYTVFSTVGAFYLPLCVVLFVYWKIY----RAAKFRMGSRKTNSVSPVPEAVEVKNATQHPQMVFTVrhatvtf 268
Cdd:cd15959 161 fVTNMP-YAIVSSTVSFYVPLLVMIFVYVRVFvvatRQVRLIRKDKVRFPPEESPPAESRPACGRRPSRLLAI------- 232
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 269 qtegdtwreqKEQRAALMVGILIGVFVLCWFPFFVTELISPLCSWDVPAIWKSIFLWLGYSNSFFNPLIY 338
Cdd:cd15959 233 ----------KEHKALKTLGIIMGTFTLCWLPFFVANIIKVFCRSLVPDPAFLFLNWLGYANSAFNPIIY 292
7tmA_Beta1_AR cd15958
beta-1 adrenergic receptors (adrenoceptors), member of the class A family of ...
58-338 8.29e-40

beta-1 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-1 adrenergic receptor (beta-1 adrenoceptor), also known as beta-1 AR, is activated by adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320624 [Multi-domain]  Cd Length: 298  Bit Score: 142.73  E-value: 8.29e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  58 NLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSGRrWQLGRRLCQLWIACDVLCCTASIWNVTAIAL 137
Cdd:cd15958  18 NVLVIVAIGRTQRLQTLTNLFITSLACADLVMGLLVVPFGATLVVRGR-WLYGSFFCELWTSVDVLCVTASIETLCVIAI 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 138 DRYWSITRHLEY-TLRTRKRvSNVMILLTWALSTVISLAPLLFGWG--------ETYSEPsEECQVSREPSYTVFSTVGA 208
Cdd:cd15958  97 DRYLAITSPFRYqSLLTRAR-AKGIVCTVWAISALVSFLPIMMHWWrdeddqalKCYEDP-GCCDFVTNRAYAIASSIIS 174
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 209 FYLPLCVVLFVYWKIYRAAKFRMgsRKTNSVS---PVPEAVEVKNATQHPQMVFTVRhatvtfqtegdtwreqkEQRAAL 285
Cdd:cd15958 175 FYIPLLIMIFVYLRVYREAKKQI--KKIDKCEgrfHNTLTGLGRKCKRRPSRILALR-----------------EQKALK 235
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 84370345 286 MVGILIGVFVLCWFPFFVTELISPLCSWDVPAIWKSIFLWLGYSNSFFNPLIY 338
Cdd:cd15958 236 TLGIIMGVFTLCWLPFFLVNVVNVFNRELVPDWLFVFFNWLGYANSAFNPIIY 288
7tmA_TAAR2_3_4 cd15312
trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family ...
45-349 9.31e-40

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; TAAR2, TAAR3, and TAAR4 are among the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320437 [Multi-domain]  Cd Length: 289  Bit Score: 142.11  E-value: 9.31e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  45 TLLGFLAAA---TFTWNLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSGRrWQLGRRLCQLWIACD 121
Cdd:cd15312   2 AMYLFMAGAillTVFGNLMVIISISHFKQLHSPTNFLILSLAITDFLLGFLVMPYSMVRSVESC-WYFGDLFCKIHSSLD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 122 VLCCTASIWNVTAIALDRYWSITRHLEYTLRTRKRVSNVMILLTWalstvisLAPLLFGWGETYSEPSEE---------- 191
Cdd:cd15312  81 MMLSTTSIFHLCFIAVDRYYAVCDPLHYRTKITTPVIKVFLVISW-------SVPCLFAFGVVFSEVNLEgiedyvalvs 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 192 ----CQVSREPSYTVFSTVGAFYLPLCVVLFVYWKIYRAAKfrmgsRKTNSVSPVPEA--VEVKNATQhpqmvftvrhat 265
Cdd:cd15312 154 ctgsCVLIFNKLWGVIASLIAFFIPGTVMIGIYIKIFFVAR-----KHAKVINNRPSVtkGDSKNKLS------------ 216
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 266 vtfqtegdtwrEQKEQRAALMVGILIGVFVLCWFPFFVTELISPLCSWDVPAIWKSIFLWLGYSNSFFNPLIYTAFNRSY 345
Cdd:cd15312 217 -----------KKKERKAAKTLSIVMGVFLLCWLPFFVATLIDPFLNFSTPVDLFDALVWLGYFNSTCNPLIYGFFYPWF 285

                ....
gi 84370345 346 SSAF 349
Cdd:cd15312 286 QKAF 289
7tmA_5-HT6 cd15054
serotonin receptor subtype 6, member of the class A family of seven-transmembrane G ...
41-349 5.96e-39

serotonin receptor subtype 6, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT6 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT6 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. The 5-HT6 receptors mediates excitatory neurotransmission and are involved in learning and memory; thus they are promising targets for the treatment of cognitive impairment. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320182 [Multi-domain]  Cd Length: 267  Bit Score: 139.55  E-value: 5.96e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  41 VLVLTLLGFLAAATFTWNLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSGRrWQLGRRLCQLWIAC 120
Cdd:cd15054   1 GWVAAFLCLIILLTVAGNSLLILLIFTQRSLRNTSNYFLVSLFMSDLMVGLVVMPPAMLNALYGR-WVLARDFCPIWYAF 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 121 DVLCCTASIWNVTAIALDRYWSITRHLEYTLRTRKRVSNVMILLTWALSTVISLAPLLFGWGETYSEP----------SE 190
Cdd:cd15054  80 DVMCCSASILNLCVISLDRYLLIISPLRYKLRMTPPRALALILAAWTLAALASFLPIELGWHELGHERtlpnltsgtvEG 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 191 ECQVSREPSYTVFSTVGAFYLPLCVVLFVYWKIYRAAKfrmgsrktnsvspvpeavevknatqhpqmvftvrhatvtfqt 270
Cdd:cd15054 160 QCRLLVSLPYALVASCLTFFLPSGAICFTYCRILLAAR------------------------------------------ 197
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 84370345 271 egdtwreqKEQRAALMVGILIGVFVLCWFPFFVTELISPLCSWdVPAIWKSIFLWLGYSNSFFNPLIYTAFNRSYSSAF 349
Cdd:cd15054 198 --------KALKASLTLGILLGMFFVTWLPFFVANVVQAVCDC-VSPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRAL 267
7tmA_Beta2_AR cd15957
beta-2 adrenergic receptors (adrenoceptors), member of the class A family of ...
58-338 9.48e-39

beta-2 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; Beta-2 AR is activated by adrenaline that plays important roles in cardiac function and pulmonary physiology. While beta-1 AR and beta-2 AR are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway, beta-2 AR can couple to both G(s) and G(i) proteins in the heart. Moreover, beta-2 AR activation leads to smooth muscle relaxation and bronchodilation in the lung. The beta adrenergic receptors are a subfamily of the class A rhodopsin-like G protein-coupled receptors.


Pssm-ID: 341355 [Multi-domain]  Cd Length: 301  Bit Score: 140.00  E-value: 9.48e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  58 NLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSgRRWQLGRRLCQLWIACDVLCCTASIWNVTAIAL 137
Cdd:cd15957  18 NVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILL-KTWTFGNFWCEFWTSIDVLCVTASIETLCVIAV 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 138 DRYWSITRHLEYTLRTRKRVSNVMILLTWALSTVISLAPLLFGWGET--------YSEPSeECQVSREPSYTVFSTVGAF 209
Cdd:cd15957  97 DRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRAthqeaincYAEET-CCDFFTNQAYAIASSIVSF 175
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 210 YLPLCVVLFVYWKIYRAAKFRMgsrktnsvspvpEAVEVKNATQHPQMVFTVRHAtvtfqTEGDTWREQ----KEQRAAL 285
Cdd:cd15957 176 YVPLVIMVFVYSRVFQEAKRQL------------QKIDKSEGRFHNQNIDQNGSG-----GGGGNRRRSkfclKEHKALK 238
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 84370345 286 MVGILIGVFVLCWFPFFVTELISPLCSWDVPAIWKSIFLWLGYSNSFFNPLIY 338
Cdd:cd15957 239 TLGIIMGTFTLCWLPFFIVNIVHVIQDNLIRKEVYILLNWIGYVNSGFNPLIY 291
7tmA_D2_dopamine_R cd15309
D2 subtype of the D2-like family of dopamine receptors, member of the class A family of ...
39-349 1.85e-37

D2 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320435 [Multi-domain]  Cd Length: 254  Bit Score: 135.16  E-value: 1.85e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  39 FRVLVLTLLGFLAAATftwNLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSGRrWQLGRRLCQLWI 118
Cdd:cd15309   2 YYAMLLTLLIFVIVFG---NVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGE-WRFSRIHCDIFV 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 119 ACDVLCCTASIWNVTAIALDRYWSITRHLEYTLR-TRKRVSNVMILLTWALSTVISlAPLLFGWGETysePSEECQVSrE 197
Cdd:cd15309  78 TLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRySSKRRVTVMISVVWVLSFAIS-CPLLFGLNNT---DQNECIIA-N 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 198 PSYTVFSTVGAFYLPLCVVLFVYWKIYRAAkfrmgsrktnsvspvpeavevknatqhpqmvftvrhatvtfqtegdtwre 277
Cdd:cd15309 153 PAFVVYSSIVSFYVPFIVTLLVYVQIYIVL-------------------------------------------------- 182
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 84370345 278 QKEQRAALMVGILIGVFVLCWFPFFVTELISPLCSWDVPAIWKSIFLWLGYSNSFFNPLIYTAFNRSYSSAF 349
Cdd:cd15309 183 QKEKKATQMLAIVLGVFIICWLPFFITHILNMHCDCNIPPALYSAFTWLGYVNSAVNPIIYTTFNIEFRKAF 254
7tmA_Histamine_H3R_H4R cd15048
histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G ...
41-349 9.23e-37

histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H4R, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320176 [Multi-domain]  Cd Length: 296  Bit Score: 134.35  E-value: 9.23e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  41 VLVLTLLGFLAAATFTWNLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSGRrWQLGRRLCQLWIAC 120
Cdd:cd15048   1 IVLAVLISVLILVTVIGNLLVILAFIKDKKLRTVSNFFLLNLAVADFLVGLVSMPFYIPYTLTGK-WPFGKVFCKAWLVV 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 121 DVLCCTASIWNVTAIALDRYWSITRHLEYTLRTRKRVSNVMILLTWALSTVIsLAPLLFGW---GETYSEPSEECQV--S 195
Cdd:cd15048  80 DYTLCTASALTIVLISLDRYLSVTKAVKYRAKQTKRRTVLLMALVWILAFLL-YGPAIIGWdlwTGYSIVPTGDCEVefF 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 196 REPSYTVFSTVGAFYLPLCVVLFVYWKIYRAAKFRMGSRKTNSVSPVPEavevknatqhPQMVFTVRHATvtfqtegDTW 275
Cdd:cd15048 159 DHFYFTFITSVLEFFIPFISVSFFNLLIYLNIRKRSRRRPLRSVPILPA----------SQNPSRARSQR-------EQV 221
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 84370345 276 REQKEQRAALMVGILIGVFVLCWFPFFVTELISPLCSWD-VPAIWKSIFLWLGYSNSFFNPLIYTAFNRSYSSAF 349
Cdd:cd15048 222 KLRRDRKAAKSLAILVLVFLICWAPYTILTIIRSFCSGScVDSYLYEFTFWLLWTNSAINPFLYAACHPRFRKAF 296
7tmA_TAAR5-like cd15317
trace amine-associated receptor 5 and similar receptors, member of the class A family of ...
41-349 2.50e-35

trace amine-associated receptor 5 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR5, TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified trace amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320440 [Multi-domain]  Cd Length: 290  Bit Score: 130.26  E-value: 2.50e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  41 VLVLTLLGFLAAATFTWNLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSGRrWQLGRRLCQLWIAC 120
Cdd:cd15317   1 VIIYIVLVLAMLITVSGNLVVIISISHFKQLHSPTNMLVLSLATADFLLGLCVMPFSMIRTVETC-WYFGDLFCKFHTGL 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 121 DVLCCTASIWNVTAIALDRYWSITRHLEYTLRTRKRVSNVMILLTWALSTVISLAPLLFGWGETYSEPSEE-------CQ 193
Cdd:cd15317  80 DLLLCTTSIFHLCFIAIDRYYAVCDPLRYPSKITVQVAWRFIAIGWLVPGIYTFGLIYTGANDEGLEEYSSeiscvggCQ 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 194 VSREPSYTVFSTVgAFYLPLCVVLFVYWKIYRAAKfrmgsRKTNSVspvpEAVEVKNATQHPQMVFTVRHatvtfqtegd 273
Cdd:cd15317 160 LLFNKIWVLLDFL-TFFIPCLIMIGLYAKIFLVAR-----RQARKI----QNMEDKFRSSEENSSKASAS---------- 219
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 84370345 274 twreqKEQRAALMVGILIGVFVLCWFPFFVTELISPLCSWDVPAIWKSIFLWLGYSNSFFNPLIYTAFNRSYSSAF 349
Cdd:cd15317 220 -----RERKAAKTLAIVMGIFLFCWLPYFIDTIVDEYSNFITPAIVFDAVIWLGYFNSAFNPFIYAFFYPWFRKAF 290
7tmA_D4_dopamine_R cd15308
D4 dopamine receptor of the D2-like family, member of the class A family of ...
58-349 4.39e-35

D4 dopamine receptor of the D2-like family, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320434 [Multi-domain]  Cd Length: 258  Bit Score: 128.80  E-value: 4.39e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  58 NLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSGRRWQLGRRLCQLWIACDVLCCTASIWNVTAIAL 137
Cdd:cd15308  18 NVLVCLSVCTERALKTTTNYFIVSLAVADLLLALLVLPLYVYSEFQGGVWTLSPVLCDALMTMDVMLCTASIFNLCAISV 97
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 138 DRYWSITRHLEYTLRTRKRVSNVMILLTWALSTVISlAPLLFGWGETYSEPSEECQVsREPSYTVFSTVGAFYLPLCVVL 217
Cdd:cd15308  98 DRFIAVSVPLNYNRRQGSVRQLLLISATWILSFAVA-SPVIFGLNNVPNRDPAVCKL-EDNNYVVYSSVCSFFIPCPVML 175
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 218 FVYWKIYRAAKfrmgsrktnsvspvpeavevknatqhpqmvftvrhatvtfqtegdtwreqKEQRAALMVGILIGVFVLC 297
Cdd:cd15308 176 VLYCAMFRGLG--------------------------------------------------RERKAMRVLPVVVGAFLFC 205
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 84370345 298 WFPFFVTELISPLC-SWDVPAIWKSIFLWLGYSNSFFNPLIYTAFNRSYSSAF 349
Cdd:cd15308 206 WTPFFVVHITRALCeSCSIPPQLISIVTWLGYVNSALNPVIYTVFNAEFRNVF 258
7tmA_Opsins_type2_animals cd14969
type 2 opsins in animals, member of the class A family of seven-transmembrane G ...
45-349 1.57e-33

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.


Pssm-ID: 381741 [Multi-domain]  Cd Length: 284  Bit Score: 125.40  E-value: 1.57e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  45 TLLGFLAAATFTWNLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSGrRWQLGRRLCQlWIACDV-L 123
Cdd:cd14969   5 VYLSLIGVLGVVLNGLVIIVFLKKKKLRTPLNLFLLNLALADLLMSVVGYPLSFYSNLSG-RWSFGDPGCV-IYGFAVtF 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 124 CCTASIWNVTAIALDRYWSITRHLEYTlRTRKRVSNVMILLTWALSTVISLAPlLFGWGETYSEPSE-ECQV---SREP- 198
Cdd:cd14969  83 LGLVSISTLAALAFERYLVIVRPLKAF-RLSKRRALILIAFIWLYGLFWALPP-LFGWSSYVPEGGGtSCSVdwySKDPn 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 199 --SYTVFSTVGAFYLPLCVVLFVYWKIYRaakfrmgsrktnsvspvpeavevknatqhpqmvfTVRHATVTFQTEGDTWR 276
Cdd:cd14969 161 slSYIVSLFVFCFFLPLAIIIFCYYKIYR----------------------------------TLRKMSKRAARRKNSAI 206
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 277 EQK----EQRAALMVGILIGVFVLCWFP---------FFVTELISPLCSwDVPAIwksiflwLGYSNSFFNPLIYTAFNR 343
Cdd:cd14969 207 TKRtkkaEKKVAKMVLVMIVAFLIAWTPyavvslyvsFGGESTIPPLLA-TIPAL-------FAKSSTIYNPIIYVFMNK 278

                ....*.
gi 84370345 344 SYSSAF 349
Cdd:cd14969 279 QFRRAL 284
7tmA_mAChR_M1 cd17790
muscarinic acetylcholine receptor subtype M1, member of the class A family of ...
41-349 1.85e-33

muscarinic acetylcholine receptor subtype M1, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. M1 is the dominant mAChR subtype involved in learning and memory. It is linked to synaptic plasticity, neuronal excitability, and neuronal differentiation during early development. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341356 [Multi-domain]  Cd Length: 262  Bit Score: 124.70  E-value: 1.85e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  41 VLVLTLLGFLAAATFTWNLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSGRrWQLGRRLCQLWIAC 120
Cdd:cd17790   1 VLIVITTGILSLVTVTGNLLVLISFKVNSELKTVNNYFLLSLACADLIIGAFSMNLYTTYILMGH-WALGTVACDLWLAL 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 121 DVLCCTASIWNVTAIALDRYWSITRHLEYTLRTRKRVSNVMILLTWALSTVIsLAPLLFGWGETYSE---PSEEC--QVS 195
Cdd:cd17790  80 DYVASNASVMNLLIISFDRYFSITRPLTYRAKRTPRRAAIMIGLAWLISFVL-WAPAILFWQYLVGErtvLAGQCyiQFL 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 196 REPSYTVFSTVGAFYLPLCVVLFVYWKIYRaakfrmgsrktnsvspvpEAVevknatqhpqmvftvrhatvtfqtegdtw 275
Cdd:cd17790 159 SQPIITFGTAIAAFYLPVTIMIILYWRIYR------------------ETI----------------------------- 191
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 84370345 276 reqKEQRAALMVGILIGVFVLCWFPFFVTELISPLCSWDVPAIWKSIFLWLGYSNSFFNPLIYTAFNRSYSSAF 349
Cdd:cd17790 192 ---KEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPKTLWELGYWLCYVNSTVNPMCYALCNKSFRDTF 262
7tmA_5-HT2C cd15305
serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G ...
34-349 3.23e-33

serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341346 [Multi-domain]  Cd Length: 275  Bit Score: 124.63  E-value: 3.23e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  34 PFLSAFRVLVLTLLGflaaatftwNLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSGRRWQLGRRL 113
Cdd:cd15305   3 PALLILIIIILTIGG---------NILVIMAVSLEKKLQNATNFFLMSLAVADMLVGILVMPVSLIAILYDYAWPLPRYL 73
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 114 CQLWIACDVLCCTASIWNVTAIALDRYWSITRHLEYTlRTRKRVSNVM-ILLTWALSTVISLAPLLFGWGETYSEPSEEC 192
Cdd:cd15305  74 CPIWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHS-RFNSRTKAMMkIAAVWTISIGISMPIPVIGLQDDEKVFVNGT 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 193 QVSREPSYTVFSTVGAFYLPLCVVLFVYwkiyraakfrmgsrktnsvspvpeavevknatqhpqmvftvrhaTVTFQTEG 272
Cdd:cd15305 153 CVLNDENFVLIGSFVAFFIPLIIMVITY--------------------------------------------CLTIQVLQ 188
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 273 DTWREQKEQRAALMVGILIGVFVLCWFPFFVTELISPL----CSWDVPAIWKSIFLWLGYSNSFFNPLIYTAFNRSYSSA 348
Cdd:cd15305 189 RQQAINNERRASKVLGIVFFLFLIMWCPFFITNILSVLckeaCDQKLMEELLNVFVWVGYVSSGINPLVYTLFNKTYRRA 268

                .
gi 84370345 349 F 349
Cdd:cd15305 269 F 269
7tmA_5-HT2A cd15304
serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G ...
34-349 1.23e-32

serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341345 [Multi-domain]  Cd Length: 267  Bit Score: 122.73  E-value: 1.23e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  34 PFLSAFRVLVLTLLGflaaatftwNLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSGRRWQLGRRL 113
Cdd:cd15304   3 PALLTVIVIILTIAG---------NILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKL 73
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 114 CQLWIACDVLCCTASIWNVTAIALDRYWSI---TRHLEYTLRTRKRVSnvmILLTWALSTVISLAPLLFGWGETYSEPSE 190
Cdd:cd15304  74 CAVWIYLDVLFSTASIMHLCAISLDRYIAIrnpIHHSRFNSRTKAFLK---IIAVWTISVGISMPIPVFGLQDDSKVFKE 150
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 191 ECQVSREPSYTVFSTVGAFYLPLCVVLFVYWKIYRAAKfrmgsrktNSVSpvpeavevknatqhpqmvftvrhatvtfqt 270
Cdd:cd15304 151 GSCLLADENFVLIGSFVAFFIPLTIMVITYFLTIKSLQ--------QSIS------------------------------ 192
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 271 egdtwreqKEQRAALMVGILIGVFVLCWFPFFVTELIS----PLCSWDVPAIWKSIFLWLGYSNSFFNPLIYTAFNRSYS 346
Cdd:cd15304 193 --------NEQKASKVLGIVFFLFVVMWCPFFITNVMAvickESCNEVVIGGLLNVFVWIGYLSSAVNPLVYTLFNKTYR 264

                ...
gi 84370345 347 SAF 349
Cdd:cd15304 265 SAF 267
7tmA_mAChR_M3 cd15299
muscarinic acetylcholine receptor subtype M3, member of the class A family of ...
41-353 2.79e-31

muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. The M3 receptor is mainly located in smooth muscle, exocrine glands and vascular endothelium. It induces vomiting in the central nervous system and is a critical regulator of glucose homeostasis by modulating insulin secretion. Generally, M3 receptor causes contraction of smooth muscle resulting in vasoconstriction and increased glandular secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320426 [Multi-domain]  Cd Length: 274  Bit Score: 119.28  E-value: 2.79e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  41 VLVLTLLGFLAAATFTWNLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSGRrWQLGRRLCQLWIAC 120
Cdd:cd15299   4 VLIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNR-WALGNLACDLWLSI 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 121 DVLCCTASIWNVTAIALDRYWSITRHLEY-TLRTRKRvSNVMILLTWALSTVIsLAPLLFGWGETYSE---PSEEC--QV 194
Cdd:cd15299  83 DYVASNASVMNLLVISFDRYFSITRPLTYrAKRTTKR-AGVMIGLAWVISFVL-WAPAILFWQYFVGKrtvPPDECfiQF 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 195 SREPSYTVFSTVGAFYLPLCVVLFVYWKIYRaakfrmgsrktnsvspvpEAVevknatqhpqmvftvrhatvtfqtegdt 274
Cdd:cd15299 161 LSEPIITFGTAIAAFYLPVTIMTILYWRIYK------------------ETI---------------------------- 194
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 84370345 275 wreqKEQRAALMVGILIGVFVLCWFPFFVTELISPLCSWDVPAIWKSIFLWLGYSNSFFNPLIYTAFNRSYSSAFKVFF 353
Cdd:cd15299 195 ----KEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTYWNLGYWLCYINSTVNPVCYALCNKTFRTTFKMLL 269
7tmA_CCKR-like cd14993
cholecystokinin receptors and related proteins, member of the class A family of ...
58-349 7.11e-31

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.


Pssm-ID: 320124 [Multi-domain]  Cd Length: 296  Bit Score: 118.47  E-value: 7.11e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  58 NLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSgRRWQLGRRLCQLWIACDVLCCTASIWNVTAIAL 137
Cdd:cd14993  18 NSLVIAVVLRNKHMRTVTNYFLVNLAVADLLVSLFCMPLTLLENVY-RPWVFGEVLCKAVPYLQGVSVSASVLTLVAISI 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 138 DRYWSITRHLEYTLRTRKRVSNVMILLTWALSTVISLaPLLFGWGETYSEPSEECQVSRE------PS------YTVFST 205
Cdd:cd14993  97 DRYLAICYPLKARRVSTKRRARIIIVAIWVIAIIIML-PLLVVYELEEIISSEPGTITIYictedwPSpelrkaYNVALF 175
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 206 VGAFYLPLCVVLFVYWKIYRaakfRMGSRKtnsvspVPEAVEVKNATQhpqmvftvrhatvtfqtegDTWREQKEQRAAL 285
Cdd:cd14993 176 VVLYVLPLLIISVAYSLIGR----RLWRRK------PPGDRGSANSTS-------------------SRRILRSKKKVAR 226
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 286 MVGILIGVFVLCWFPFFVTELI------SPLCSWDVPAIWKSIFLWLGYSNSFFNPLIYTAFNRSYSSAF 349
Cdd:cd14993 227 MLIVVVVLFALSWLPYYVLSILldfgplSSEESDENFLLILPFAQLLGYSNSAINPIIYCFMSKKFRRGF 296
7tmA_5-HT2B cd15306
serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G ...
58-349 3.13e-30

serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341347 [Multi-domain]  Cd Length: 277  Bit Score: 116.47  E-value: 3.13e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  58 NLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSGRRWQLGRRLCQLWIACDVLCCTASIWNVTAIAL 137
Cdd:cd15306  18 NILVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTILFEAMWPLPLVLCPIWLFLDVLFSTASIMHLCAISL 97
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 138 DRYWSITRHLEYTLRTRKRVSNVMILLTWALSTVISLAPLLFGWGETYSEPSE-ECQVSREP--SYTVFSTVGAFYLPLC 214
Cdd:cd15306  98 DRYIAIKKPIQASQYNSRATAFIKITVVWLISIGIAIPVPIKGIETDVDNPNNiTCVLTKERfgDFILFGSLAAFFTPLA 177
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 215 VVLFVYWKIYRAakfrmgsrktnsvspvpeavevknatqhpqmvftVRHATVTfqtegdtwreqKEQRAALMVGILIGVF 294
Cdd:cd15306 178 IMIVTYFLTIHA----------------------------------LRKQTIT-----------NEQRASKVLGIVFFLF 212
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 84370345 295 VLCWFPFFVTELISPL---CSWDVPAIWKSIFLWLGYSNSFFNPLIYTAFNRSYSSAF 349
Cdd:cd15306 213 LLMWCPFFITNITSVLcdsCNQTTLQMLMEIFVWIGYVSSGVNPLVYTLFNKTFRDAF 270
7tmA_GPR119_R_insulinotropic_receptor cd15104
G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member ...
45-349 4.43e-30

G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR119 is activated by oleoylethanolamide (OEA), a naturally occurring bioactive lipid with hypophagic and anti-obesity effects. Immunohistochemistry and double-immunofluorescence studies revealed the predominant GPR119 localization in pancreatic polypeptide (PP)-cells of islets. In addition, GPR119 expression is elevated in islets of obese hyperglycemic mice as compared to control islets, suggesting a possible involvement of this receptor in the development of obesity and diabetes. GPR119 has a significant sequence similarity with the members of the endothelial differentiation gene family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320232 [Multi-domain]  Cd Length: 283  Bit Score: 116.32  E-value: 4.43e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  45 TLLGFLAAATFTWNLLVLATILKVRTFHRVPHN-LVASMAISDVLVAVLvMPLSLVHELSGRRWQLGRRLCQLWIACDVL 123
Cdd:cd15104   4 VILAVLSPLIITGNLLVIVALLKLIRKKDTKSNcFLLNLAIADFLVGLA-IPGLATDELLSDGENTQKVLCLLRMCFVIT 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 124 CCTASIWNVTAIALDRYWSITRHLEYTLRTRKRVSNVMILLTWALSTVISLAPLLFG--WGETYSEP-SEECQVSREPSY 200
Cdd:cd15104  83 SCAASVLSLAAIAFDRYLALKQPLRYKQIMTGKSAGALIAGLWLYSGLIGFLPLISPqfQQTSYKGKcSFFAAFHPRVLL 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 201 TVFSTVgafYLPLCVVL-FVYWKIYRAAKfrmgsrktnsvspvpeavevknatQHPQMVFTVRHATVTFQTEGDTWREQK 279
Cdd:cd15104 163 VLSCMV---FFPALLLFvFCYCDILKIAR------------------------VHSRAIYKVEHALARQIHPRRTLSDFK 215
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 84370345 280 eqrAALMVGILIGVFVLCWFPFFVTELISPLCSWDVPAIWKSIFLW-LGYSNSFFNPLIYTAFNRSYSSAF 349
Cdd:cd15104 216 ---AARTVAVLIGCFLLSWLPFQITGLVQALCDECKLYDVLEDYLWlLGLCNSLLNPWIYAFWQKEVRRAL 283
7tmA_mAChR_GAR-2-like cd15302
muscarinic acetylcholine receptor GAR-2 and similar proteins, member of the class A family of ...
41-349 5.62e-30

muscarinic acetylcholine receptor GAR-2 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320429 [Multi-domain]  Cd Length: 266  Bit Score: 115.61  E-value: 5.62e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  41 VLVLTLLGFLAAATFTWNLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSGRRWQLGRRLCQLWIAC 120
Cdd:cd15302   1 ILLALITAILSIITVIGNILVLLSFYVDRNIRQPSNYFIASLAVSDLLIGLESMPFYTVYVLNGDYWPLGWVLCDLWLSV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 121 DVLCCTASIWNVTAIALDRYWSITRHLEY-TLRTRKRVSnVMILLTWALSTVIsLAPLLFGW----GETYSEPSEEC--Q 193
Cdd:cd15302  81 DYTVCLVSIYTVLLITIDRYCSVKIPAKYrNWRTPRKVL-LIIAITWIIPALL-FFISIFGWqyftGQGRSLPEGECyvQ 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 194 VSREPSYTVFSTVGAFYLPLCVVLFVYWKIYRAAKfrmgsrktnsvspvpeavevknatqhpqmvftvrhatvtfqtegd 273
Cdd:cd15302 159 FMTDPYFNMGMYIGYYWTTLIVMLILYAGIYRAAN--------------------------------------------- 193
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 84370345 274 twREQKEQRAalmVGILIGVFVLCWFPFFVTELISPLCSWD--VPAIWKSIFLWLGYSNSFFNPLIYTAFNRSYSSAF 349
Cdd:cd15302 194 --RARKALRT---ITFILGAFVICWTPYHILATIYGFCEAPpcVNETLYTISYYLCYMNSPINPFCYALANQQFKKTF 266
7tmA_TAAR6_8_9 cd15316
trace amine-associated receptors 6, 8, and 9, member of the class A family of ...
41-341 7.59e-30

trace amine-associated receptors 6, 8, and 9, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320439 [Multi-domain]  Cd Length: 290  Bit Score: 115.73  E-value: 7.59e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  41 VLVLTLLGFLAAATFTWNLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSGRrWQLGRRLCQLWIAC 120
Cdd:cd15316   1 VILYIVLGFGAVLAVFGNLLVMISILHFKQLHSPTNFLIASLACADFLVGVTVMPFSTVRSVESC-WYFGESFCTFHTCC 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 121 DVLCCTASIWNVTAIALDRYWSITRHLEYTLRTRKRVSNVMILLTWALSTVISLAPLLFGwgeTYSEPSEE--------- 191
Cdd:cd15316  80 DVSFCYASLFHLCFISVDRYIAVTDPLVYPTKFTVSVSGICISVSWIFSLTYSFSVFYTG---VNDDGLEElvnalncvg 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 192 -CQVSREPSYTVFSTVgAFYLPLCVVLFVYWKIYRAAKFRmgSRKTNSVSpvpeavevkNATQHPQMVFTVRHAtvtfqt 270
Cdd:cd15316 157 gCQIILNQNWVLVDFL-LFFIPTFAMIILYGKIFLVAKQQ--ARKIEMTS---------SKAESSSESYKDRVA------ 218
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 84370345 271 egdtwreQKEQRAALMVGILIGVFVLCWFPFFVTELISPLCSWDVPAIWKSIFLWLGYSNSFFNPLIYTAF 341
Cdd:cd15316 219 -------RRERKAAKTLGITVIAFLVSWLPYLIDVLIDAFMNFITPPYIYEICCWCAYYNSAMNPLIYALF 282
7tmA_5-HT2_insect-like cd15307
serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane ...
42-350 9.35e-30

serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320433 [Multi-domain]  Cd Length: 279  Bit Score: 115.43  E-value: 9.35e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  42 LVLTLLGFLAAATftwNLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSGRrWQLGRRLCQLWIACD 121
Cdd:cd15307   5 LLALVLVLGTAAG---NILVCLAIAWERRLQNVTNYFLMSLAITDLMVAVLVMPLGILTLVKGH-FPLSSEHCLTWICLD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 122 VLCCTASIWNVTAIALDRYWSITRHLEYTL-RTRKRVSnVMILLTWALSTVISLA-PLLFGWGETYSEPSEECQVSrEPS 199
Cdd:cd15307  81 VLFCTASIMHLCTISVDRYLSLRYPMRFGRnKTRRRVT-LKIVFVWLLSIAMSLPlSLMYSKDHASVLVNGTCQIP-DPV 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 200 YTVFSTVGAFYLPLCVVLFVYwkiyrAAKFRMGSRKTNsvspvpeavevknatqhpqmvftvRHATVTfqtegdtwreQK 279
Cdd:cd15307 159 YKLVGSIVCFYIPLGVMLLTY-----CLTVRLLARQRS------------------------RHGRII----------RL 199
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 84370345 280 EQRAALMVGILIGVFVLCWFPFFVTELISPLCSWDVPAIWKSIF---LWLGYSNSFFNPLIYTAFNRSYSSAFK 350
Cdd:cd15307 200 EQKATKVLGVVFFTFVILWSPFFVLNLLPTVCAECEERISHWVFdvvTWLGYASSMVNPIFYTIFNKVFRQAFK 273
7tmA_mAChR_DM1-like cd15301
muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G ...
41-345 5.05e-29

muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes muscarinic acetylcholine receptor DM1-like from invertebrates. Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320428 [Multi-domain]  Cd Length: 270  Bit Score: 112.99  E-value: 5.05e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  41 VLVLTLLGFLAAATFTWNLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSGRrWQLGRRLCQLWIAC 120
Cdd:cd15301   1 VLIVIVAAVLSLVTVGGNVMVMISFKIDKQLQTISNYFLFSLAVADFAIGVISMPLFTVYTALGY-WPLGYEVCDTWLAI 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 121 DVLCCTASIWNVTAIALDRYWSITRHLEYTLRTRKRVSNVMILLTWALSTVIsLAPLLFGWGET---YSEPSEECQVS-- 195
Cdd:cd15301  80 DYLASNASVLNLLIISFDRYFSVTRPLTYRARRTTKKAAVMIASAWIISLLL-WPPWIYSWPYIegkRTVPAGTCYIQfl 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 196 -REPSYTVFSTVGAFYLPLCVVLFVYWKIYRAAKFRmgsrktnsvspvpeavevknatqhpqmvftvrhatvtfqtegdt 274
Cdd:cd15301 159 eTNPYVTFGTALAAFYVPVTIMCILYWRIWRETKKR-------------------------------------------- 194
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 84370345 275 wREQKEQRAALMVGILIGVFVLCWFPFFVTELISPL--CSWDVPAIWKSIFLWLGYSNSFFNPLIYTAFNRSY 345
Cdd:cd15301 195 -QKKQESKAAKTLSAILLAFIVTWTPYNVLVLIKAFfpCSDTIPTELWDFSYYLCYINSTINPLCYALCNAAF 266
7tmA_mAChR_M2 cd15297
muscarinic acetylcholine receptor subtype M2, member of the class A family of ...
41-349 9.31e-29

muscarinic acetylcholine receptor subtype M2, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of M2 receptor causes a decrease in cAMP production, generally leading to inhibitory-type effects. This causes an outward current of potassium in the heart, resulting in a decreased heart rate. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320424 [Multi-domain]  Cd Length: 262  Bit Score: 112.37  E-value: 9.31e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  41 VLVLTLLGFLAAATFTWNLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSGRrWQLGRRLCQLWIAC 120
Cdd:cd15297   1 VFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGY-WPLGPVVCDLWLAL 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 121 DVLCCTASIWNVTAIALDRYWSITRHLEYTLRTRKRVSNVMILLTWALSTVIsLAPLLFGW-----GETYSEPSEECQVS 195
Cdd:cd15297  80 DYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFIL-WAPAILFWqfivgGRTVPEGECYIQFF 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 196 REPSYTVFSTVGAFYLPLCVVLFVYWKIYRAAKfrmgsrktnsvspvpeavevknatqhpqmvftvrhatvtfqtegdtw 275
Cdd:cd15297 159 SNAAVTFGTAIAAFYLPVIIMTVLYWQISRASS----------------------------------------------- 191
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 84370345 276 REQKEQRAalMVGILIGvFVLCWFPFFVTELISPLCSWDVPAIWKSIFLWLGYSNSFFNPLIYTAFNRSYSSAF 349
Cdd:cd15297 192 REKKVTRT--ILAILLA-FIITWTPYNVMVLINTFCASCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTF 262
7tmA_mAChR_M5 cd15300
muscarinic acetylcholine receptor subtype M5, member of the class A family of ...
41-349 8.91e-28

muscarinic acetylcholine receptor subtype M5, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. M5 mAChR is primarily found in the central nervous system and mediates acetylcholine-induced dilation of cerebral blood vessels. Activation of M5 receptor triggers a variety of cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides, and modulation of potassium channels. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320427 [Multi-domain]  Cd Length: 262  Bit Score: 109.73  E-value: 8.91e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  41 VLVLTLLGFLAAATFTWNLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSGRrWQLGRRLCQLWIAC 120
Cdd:cd15300   1 ITIAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLYTSYILMGY-WALGSLACDLWLAL 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 121 DVLCCTASIWNVTAIALDRYWSITRHLEYTLRTRKRVSNVMILLTWALSTVIsLAPLLFGWGETYSE---PSEECQVS-- 195
Cdd:cd15300  80 DYVASNASVMNLLVISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLISFIL-WAPPILCWQYFVGKrtvPERECQIQfl 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 196 REPSYTVFSTVGAFYLPLCVVLFVYWKIYRaakfrmgsrktnsvspvpEAVevknatqhpqmvftvrhatvtfqtegdtw 275
Cdd:cd15300 159 SEPTITFGTAIAAFYIPVSVMTILYCRIYK------------------ETI----------------------------- 191
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 84370345 276 reqKEQRAALMVGILIGVFVLCWFPFFVTELISPLCSWDVPAIWKSIFLWLGYSNSFFNPLIYTAFNRSYSSAF 349
Cdd:cd15300 192 ---KERKAAQTLSAILLAFIITWTPYNIMVLVSTFCSDCIPLTLWHLGYWLCYVNSTVNPMCYALCNKTFRKTF 262
7tmA_Adenosine_R cd14968
adenosine receptor subfamily, member of the class A family of seven-transmembrane G ...
58-349 7.52e-27

adenosine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine receptors (or P1 receptors), a family of G protein-coupled purinergic receptors, bind adenosine as their endogenous ligand. There are four types of adenosine receptors in human, designated as A1, A2A, A2B, and A3. Each type is encoded by a different gene and has distinct functions with some overlap. For example, both A1 and A2A receptors are involved in regulating myocardial oxygen consumption and coronary blood flow in the heart, while the A2A receptor also has a broad spectrum of anti-inflammatory effects in the body. These two receptors also expressed in the brain, where they have important roles in the release of other neurotransmitters such as dopamine and glutamate, while the A2B and A3 receptors found primarily in the periphery and play important roles in inflammation and immune responses. The A1 and A3 receptors preferentially interact with G proteins of the G(i/o) family, thereby lowering the intracellular cAMP levels, whereas the A2A and A2B receptors interact with G proteins of the G(s) family, activating adenylate cyclase to elevate cAMP levels.


Pssm-ID: 341316 [Multi-domain]  Cd Length: 285  Bit Score: 107.34  E-value: 7.52e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  58 NLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVhelSGRRWQLGRRLCqLWIACDVLC-CTASIWNVTAIA 136
Cdd:cd14968  18 NVLVIWAVKLNRALRTVTNYFIVSLAVADILVGALAIPLAIL---ISLGLPTNFHGC-LFMACLVLVlTQSSIFSLLAIA 93
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 137 LDRYWSITRHLEYTLRTRKRVSNVMILLTWALSTVISLAPLlFGW------GETYSEPSEECQ---VSREPSYTVFSTVG 207
Cdd:cd14968  94 IDRYLAIKIPLRYKSLVTGRRAWGAIAVCWVLSFLVGLTPM-FGWnngaplESGCGEGGIQCLfeeVIPMDYMVYFNFFA 172
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 208 AFYLPLCVVLFVYWKIYRAAKFRMGSRKTNSVSPVPEAvevknatqhpqmvftvrhatvtfqtegdtwREQKEQRAALMV 287
Cdd:cd14968 173 CVLVPLLIMLVIYLRIFRVIRKQLRQIESLLRSRRSRS------------------------------TLQKEVKAAKSL 222
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 84370345 288 GILIGVFVLCWFPFFVTELISPLC-SWDVPAIWKSIFLWLGYSNSFFNPLIYTAFNRSYSSAF 349
Cdd:cd14968 223 AIILFLFALCWLPLHIINCITLFCpECKVPKILTYIAILLSHANSAVNPIVYAYRIRKFRQTF 285
7tmA_EDG-like cd14972
endothelial differentiation gene family, member of the class A family of seven-transmembrane G ...
58-339 4.90e-26

endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 341317 [Multi-domain]  Cd Length: 275  Bit Score: 105.07  E-value: 4.90e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  58 NLLVLATILKVRTFHRVPHNLVASMAISDVLVA---VLVMPLSLVHELSGRRWQLGRRLCQLwiacdVLCCTASIWNVTA 134
Cdd:cd14972  16 NSLVLAAIIKNRRLHKPMYILIANLAAADLLAGiafVFTFLSVLLVSLTPSPATWLLRKGSL-----VLSLLASAYSLLA 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 135 IALDRYWSITRHLEYTLRTRKRVSNVMILLTWALSTVISLAPlLFGWGETYSePSEECQVSREP---SYTVFSTVgAFYL 211
Cdd:cd14972  91 IAVDRYISIVHGLTYVNNVTNKRVKVLIALVWVWSVLLALLP-VLGWNCVLC-DQESCSPLGPGlpkSYLVLILV-FFFI 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 212 PLCVVLFVYWKIYRAAKFRMgsrktnsvspvpeavevknatqhpqmvftvrHATVTFQTEGDTWREQKEQRAALMVGILI 291
Cdd:cd14972 168 ALVIIVFLYVRIFWCLWRHA-------------------------------NAIAARQEAAVPAQPSTSRKLAKTVVIVL 216
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 84370345 292 GVFVLCWFPFFVTELISPLCSWDV-PAIWKSIFLWLGYSNSFFNPLIYT 339
Cdd:cd14972 217 GVFLVCWLPLLILLVLDVLCPSVCdIQAVFYYFLVLALLNSAINPIIYA 265
7tmA_NPYR-like cd15203
neuropeptide Y receptors and related proteins, member of the class A family of ...
42-349 2.17e-25

neuropeptide Y receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to Gi or Go proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. Also included in this subgroup is prolactin-releasing peptide (PrRP) receptor (previously known as GPR10), which is activated by its endogenous ligand PrRP, a neuropeptide possessing C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acid residues (PrRP-20) and the other consists of 31 amino acid residues (PrRP-31). PrRP receptor shows significant sequence homology to the NPY receptors, and a micromolar level of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors.


Pssm-ID: 320331 [Multi-domain]  Cd Length: 293  Bit Score: 103.84  E-value: 2.17e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  42 LVLTLLGFLAaatftwNLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSgRRWQLGRRLCQL--WIA 119
Cdd:cd15203   8 GLIIVLGVVG------NLLVIYVVLRNKSMQTVTNIFILNLAVSDLLLCLVSLPFTLIYTLT-KNWPFGSILCKLvpSLQ 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 120 CDVLCCtaSIWNVTAIALDRYWSITRHleytlrTRKRVSN----VMILLTWALSTVISLaPLLF---GWGETYSEPSEEC 192
Cdd:cd15203  81 GVSIFV--STLTLTAIAIDRYQLIVYP------TRPRMSKrhalLIIALIWILSLLLSL-PLAIfqeLSDVPIEILPYCG 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 193 QVSRE--PS------YTVFSTVGAFYLPLCVVLFVYWKIYRaakfRMGSRktnsvspvpeavevknatqhpqmvFTVRHA 264
Cdd:cd15203 152 YFCTEswPSsssrliYTISVLVLQFVIPLLIISFCYFRISL----KLRKR------------------------VKKKRG 203
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 265 TVTFQTEGDTWREQKEQRAALMVGILIGVFVLCWFPFFVTELIS-----PLCSWDVPAIWKSIFLWLGYSNSFFNPLIYT 339
Cdd:cd15203 204 KRTLSSRRRRSELRRKRRTNRLLIAMVVVFAVCWLPLNLFNLLRdfeplPQIDGRHFYLIFLICHLIAMSSACVNPLLYG 283
                       330
                ....*....|
gi 84370345 340 AFNRSYSSAF 349
Cdd:cd15203 284 WLNDNFRKEF 293
7tmA_Melanopsin-like cd15083
vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane ...
41-340 5.03e-24

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represent the Gq-coupled rhodopsin subfamily consists of melanopsins, insect photoreceptors R1-R6, invertebrate Gq opsins as well as their closely related opsins. Melanopsins (also called Opsin-4) are the primary photoreceptor molecules for non-visual functions such as the photo-entrainment of the circadian rhythm and pupillary constriction in mammals. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. The outer photoreceptors (R1-R6) are the insect Drosophila equivalent to the vertebrate rods and are responsible for image formation and motion detection. The invertebrate G(q) opsins includes the arthropod and mollusk visual opsins as well as invertebrate melanopsins, which are also found in vertebrates. Arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. Members of this subfamily belong to the class A of the G protein-coupled receptors and have seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320211 [Multi-domain]  Cd Length: 291  Bit Score: 100.10  E-value: 5.03e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  41 VLVLTLLGFLAaatftwNLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSGRrWQLGRRLCQLWIAC 120
Cdd:cd15083   7 ILIIGLIGVVG------NGLVIYAFCRFKSLRTPANYLIINLAISDFLMCILNCPLMVISSFSGR-WIFGKTGCDMYGFS 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 121 DVLCCTASIWNVTAIALDRYWSITRHLEYTLRTRKRVSNVMILLTWALSTVISLAPlLFGWGeTYSepSEECQV------ 194
Cdd:cd15083  80 GGLFGIMSINTLAAIAVDRYLVITRPMKASVRISHRRALIVIAVVWLYSLLWVLPP-LFGWS-RYV--LEGLLTscsfdy 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 195 -SREP---SYTVFSTVGAFYLPLCVVLFVYWKIYRAAK------FRMGSRKTNSVSPVPEAvevknatqhpqmvftvrha 264
Cdd:cd15083 156 lSRDDanrSYVICLLIFGFVLPLLIIIYCYSFIFRAVRrhekamKEMAKRFSKSELSSPKA------------------- 216
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 84370345 265 tvtfqtegdtwREQKEQRAALMVGILIGVFVLCWFPFFVTELISPLCSWD-VPAIWKSIFLWLGYSNSFFNPLIYTA 340
Cdd:cd15083 217 -----------RRQAEVKTAKIALLLVLLFCLAWTPYAVVALIGQFGYLEvLTPLATAIPAAFAKTSAIYNPVIYAF 282
7tmA_Peropsin cd15073
retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of ...
58-348 8.29e-23

retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of seven-transmembrane G protein-coupled receptors; Peropsin, also known as a retinal pigment epithelium-derived rhodopsin homolog (RRH), is a visual pigment-like protein found exclusively in the apical microvilli of the retinal pigment epithelium. Peropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Peropsin presumably plays a physiological role in the retinal pigment epithelium either by detecting light directly or monitoring the levels of retinoids, the primary light absorber in visual perception, or other pigment-related compounds in the eye.


Pssm-ID: 320201 [Multi-domain]  Cd Length: 280  Bit Score: 96.34  E-value: 8.29e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  58 NLLVLATILKVRTFhRVPHN-LVASMAISDVLVAVLVMPLSLVHELSGRrWQLGRRLCQLWIACDVLCCTASIWNVTAIA 136
Cdd:cd15073  18 NGIVLVTFVKFREL-RTPTNaLIINLAVTDLGVSIIGYPFSAASDLHGS-WKFGYAGCQWYAFLNIFFGMASIGLLTVVA 95
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 137 LDRYWSITRHlEYTLRTRKRVSNVMILLTWALSTVISLAPLLfGWGETYSEPSE-------ECQVSREPSYTVFSTVGAF 209
Cdd:cd15073  96 VDRYLTICRP-DLGRKMTTNTYTVMILLAWTNAFFWAAMPLV-GWASYALDPTGatctinwRKNDSSFVSYTMSVIVVNF 173
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 210 YLPLCVVLFVYWKIYRAAKFRMGSRKTNSVSpvpeavevknatqhpqmvftvrhatvtfqtegDTWREQKEqrAALMVGI 289
Cdd:cd15073 174 IVPLAVMFYCYYNVSRFVKKVLASDCLESVN--------------------------------IDWTDQND--VTKMSVI 219
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 84370345 290 LIGVFVLCWFPFfvteliSPLCSW-------DVPAIWKSIFLWLGYSNSFFNPLIYTAFNRSYSSA 348
Cdd:cd15073 220 MIVMFLVAWSPY------SIVCLWasfgepkKIPPWMAIIPPLFAKSSTFYNPCIYVIANKKFRRA 279
7tmA_mAChR_M4 cd15298
muscarinic acetylcholine receptor subtype M4, member of the class A family of ...
41-349 8.96e-23

muscarinic acetylcholine receptor subtype M4, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to G(i/o) types of G proteins. The M4 receptor is mainly found in the CNS and function as an inhibitory autoreceptor regulating acetycholine release. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341344 [Multi-domain]  Cd Length: 262  Bit Score: 95.86  E-value: 8.96e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  41 VLVLTLLGFLAAATFTWNLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSGRrWQLGRRLCQLWIAC 120
Cdd:cd15298   1 VFIATVTGSLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLACADLIIGAFSMNLYTVYIIKGY-WPLGAVVCDLWLAL 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 121 DVLCCTASIWNVTAIALDRYWSITRHLEYTLRTRKRVSNVMILLTWALSTVIsLAPLLFGWGETYSE---PSEEC--QVS 195
Cdd:cd15298  80 DYVVSNASVMNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVL-WAPAILFWQFVVGKrtvPDNQCfiQFL 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 196 REPSYTVFSTVGAFYLPLCVVLFVYWKIYRAAKfrmgsrktnsvspvpeavevknatqhpqmvftvrhatvtfqtegdtw 275
Cdd:cd15298 159 SNPAVTFGTAIAAFYLPVVIMTVLYIHISLASA----------------------------------------------- 191
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 84370345 276 REQKEQRAalMVGILIGvFVLCWFPFFVTELISPLCSWDVPAIWKSIFLWLGYSNSFFNPLIYTAFNRSYSSAF 349
Cdd:cd15298 192 RERKVTRT--IFAILLA-FILTWTPYNVMVLVNTFCQSCIPDTVWSIGYWLCYVNSTINPACYALCNATFKKTF 262
7tmA_Histamine_H4R cd15295
histamine receptor subtype H4R, member of the class A family of seven-transmembrane G ...
41-352 3.01e-22

histamine receptor subtype H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtype H4R, a member of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320422 [Multi-domain]  Cd Length: 267  Bit Score: 94.51  E-value: 3.01e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  41 VLVLTLLGFLAAATFTWNLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSGRrWQLGRRLCQLWIAC 120
Cdd:cd15295   1 VVLLFLMSLLALVIVLGNALVIIAFVVDKNLRHRSNYFFLNLAISDFFVGAISIPLYIPYTLTNR-WDFGRGLCVFWLVI 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 121 DVLCCTASIWNVTAIALDRYWSITRHLEYTLRTRKRVSNVMILL-TWALSTVISlAPLLFGWGETYSEPSE-ECQVSREP 198
Cdd:cd15295  80 DYLLCTASVYNIVLISYDRYQSVSNAVSYRNQQTATLRIVTQMVaVWVLAFLVH-GPAILVSDSWKTEDGEcEPEFFSNW 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 199 SYTVFSTVGAFYLPLCVVLFVYWKIYRAakfrmgsrktnsvspvpeavevknatqhpqmvftvrhatvtfqtegdTWREQ 278
Cdd:cd15295 159 YILAITSVLEFLVPVILVAYFNTQIYWS-----------------------------------------------LWKRL 191
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 84370345 279 KEQRAALMVGILIGVFVLCWFPFFVTELISPLCSWDVPAIWKSIFLWLGYSNSFFNPLIYTAFNRSYSSAF-KVF 352
Cdd:cd15295 192 RDRKLAKSLAIILGTFAICWAPYSLFTIIRAACEKHRGSPWYNFAFWLQWFNSFINPFLYPLCHKRFRKAFlKIF 266
7tmA_photoreceptors_insect cd15079
insect photoreceptors R1-R6 and similar proteins, member of the class A family of ...
73-338 3.36e-22

insect photoreceptors R1-R6 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the insect photoreceptors and their closely related proteins. The Drosophila eye is composed of about 800 unit eyes called ommatidia, each of which contains eight photoreceptor cells (R1-R8). The six outer photoreceptors (R1-R6) function like the vertebrate rods and are responsible for motion detection in dim light and image formation. The R1-R6 photoreceptors express a blue-absorbing pigment, Rhodopsin 1(Rh1). The inner photoreceptors (R7 and R8) are considered the equivalent of the color-sensitive vertebrate cone cells, which express a range of different pigments. The R7 photoreceptors express one of two different UV absorbing pigments, either Rh3 or Rh4. Likewise, the R8 photoreceptors express either the blue absorbing pigment Rh5 or green absorbing pigment Rh6. These photoreceptors belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320207 [Multi-domain]  Cd Length: 292  Bit Score: 94.95  E-value: 3.36e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  73 RVPHN-LVASMAISDVLVaVLVMPLSLVHELSGRrWQLGRRLCQLWIACDVLCCTASIWNVTAIALDRYWSITRHLEYTL 151
Cdd:cd15079  32 RTPSNmLVVNLAISDFLM-MIKMPIFIYNSFYEG-WALGPLGCQIYAFLGSLSGIGSIWTNAAIAYDRYNVIVKPLNGNP 109
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 152 RTRKRVSnVMILLTWALSTVISLAPLLFGWGE----------TYSEPSEECQvSRepSYTVFSTVGAFYLPLCVVLFVYW 221
Cdd:cd15079 110 LTRGKAL-LLILFIWLYALPWALLPLLFGWGRyvpegfltscSFDYLTRDWN-TR--SFVATIFVFAYVIPLIIIIYCYS 185
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 222 KIYRA-----AKFRMGSRKTNSVSpvpeavevknatqhpqmvfTVRHAtvtfqtegdTWREQK-EQRAALMVGILIGVFV 295
Cdd:cd15079 186 FIVKAvfaheKALREQAKKMNVVS-------------------LRSNA---------DANKQSaEIRIAKVALTNVFLWF 237
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 84370345 296 LCWFPFFV---------TELISPLCSwdvpaIWKSIFlwlGYSNSFFNPLIY 338
Cdd:cd15079 238 IAWTPYAVvaligafgnQSLLTPLVS-----MIPALF---AKTAACYNPIVY 281
7tmA_NPFFR cd15207
neuropeptide FF receptors, member of the class A family of seven-transmembrane G ...
58-349 2.43e-21

neuropeptide FF receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320335 [Multi-domain]  Cd Length: 291  Bit Score: 92.30  E-value: 2.43e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  58 NLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLV-HELSGrrWQLGRRLCQLWIACDVLCCTASIWNVTAIA 136
Cdd:cd15207  18 NVLVCLVVAKNPRMRTVTNYFILNLAVSDLLVGVFCMPFTLVdNILTG--WPFGDVMCKLSPLVQGVSVAASVFTLVAIA 95
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 137 LDRYWSITRhleytlRTRKRVSN----VMILLTWALSTVISLaPLLFGWGETYSEPSEE-----C------QVSREPsYT 201
Cdd:cd15207  96 VDRYRAVVH------PTEPKLTNrqafVIIVAIWVLALAIMI-PQALVLEVKEYQFFRGqtvhiCvefwpsDEYRKA-YT 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 202 VFSTVGAFYLPLCVVLFVYWKIYRAAKFRmgsrktnsvsPVPEAVEVKNATQHPQMvftvrhatvtfqtegdtwreQKEQ 281
Cdd:cd15207 168 TSLFVLCYVAPLLIIAVLYVRIGYRLWFK----------PVPGGGSASREAQAAVS--------------------KKKV 217
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 84370345 282 RAALMVGILIGVFVLCWFPFFVTELIS---PLCSWDVPAIWKSIF---LWLGYSNSFFNPLIYTAFNRSYSSAF 349
Cdd:cd15207 218 RVIKMLIVVVVLFALSWLPLHTVTMLDdfgNLSPNQREVLYVYIYpiaHWLAYFNSCVNPIVYGYFNRNFRKGF 291
7tmA_PR4-like cd15392
neuropeptide Y receptor-like found in insect and related proteins, member of the class A ...
41-349 3.42e-20

neuropeptide Y receptor-like found in insect and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a novel G protein-coupled receptor (also known as PR4 receptor) from Drosophila melanogaster, which can be activated by the members of the neuropeptide Y (NPY) family, including NPY, peptide YY (PYY) and pancreatic polypeptide (PP), when expressed in Xenopus oocytes. These homologous peptides of 36-amino acids in length contain a hairpin-like structural motif, which referred to as the pancreatic polypeptide fold, and function as gastrointestinal hormones and neurotransmitters. The PR4 receptor also shares strong sequence homology to the mammalian tachykinin receptors (NK1R, NK2R, and NK3R), whose endogenous ligands are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB), respectively. The tachykinins function as excitatory transmitters on neurons and cells in the gastrointestinal tract.


Pssm-ID: 320514 [Multi-domain]  Cd Length: 287  Bit Score: 89.34  E-value: 3.42e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  41 VLVLTLLGFLAAATFTWNLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSGRRWQLGRRLCQLWIAC 120
Cdd:cd15392   1 VIIILMYSTIFVLAVGGNGLVCYIVVSYPRMRTVTNYFIVNLALSDILMAVFCVPFSFIALLILQYWPFGEFMCPVVNYL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 121 DVLCCTASIWNVTAIALDRYWSITRHLeyTLRTRKRVSNVMILLTWALSTVISLAPLLFGWGETYSEPSEECQVSRE--P 198
Cdd:cd15392  81 QAVSVFVSAFTLVAISIDRYVAIMWPL--RPRMTKRQALLLIAVIWIFALATALPIAITSRLFEDSNASCGQYICTEswP 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 199 SYT---VFSTVGA---FYLPLCVVLFVYWKIYRaakfRMGSRKTNSvspvpeavevknatqhpqmvftvrhatvtfqtEG 272
Cdd:cd15392 159 SDTnryIYSLVLMilqYFVPLAVLVFTYTRIGI----VVWAKRTPG--------------------------------EA 202
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 273 DTWREQKEQRAAL----MVGILIGVFVLCWFPFFVTELI----SPLCSWD-VPAIWkSIFLWLGYSNSFFNPLIYTAFNR 343
Cdd:cd15392 203 ENNRDQRMAESKRklvkMMITVVAIFALCWLPLNILNLVgdhdESIYSWPyIPYLW-LAAHWLAMSHCCYNPFIYCWMNA 281

                ....*.
gi 84370345 344 SYSSAF 349
Cdd:cd15392 282 KFRNGF 287
7tmA_MCHR-like cd15088
melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G ...
41-345 3.82e-20

melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320216 [Multi-domain]  Cd Length: 278  Bit Score: 89.05  E-value: 3.82e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  41 VLVLTLLGFLAAATFTWNLLVLATILKVRTFHRVPHNLVASMAISDvLVAVLVMPLSLVHELSGRRWQLGRRLCQLWIAC 120
Cdd:cd15088   1 VIMPSVFGCICVVGLVGNGIVLYVLVRCSKLRTAPDIFIFNLAVAD-LLFMLGMPFLIHQFAIDGQWYFGEVMCKIITAL 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 121 DVLCCTASIWNVTAIALDRYWSITrHLEYTLRTRKR-VSNVMILLTWALSTVISLAPLLFGWGETYSEPSEECQVSREPS 199
Cdd:cd15088  80 DANNQFTSTYILTAMSVDRYLAVV-HPIRSTKYRTRfVAKLVNVGLWAASFLSILPVWVYSSLIYFPDGTTFCYVSLPSP 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 200 -----YTVFSTVGAFYLPLCVVLFVYwkiyraakFRMGSRKTNSVSPVPEavevknatQHPqmvftvrhatvtfqtegdt 274
Cdd:cd15088 159 ddlywFTIYHFILGFAVPLVVITVCY--------ILILHRLARGVAPGNQ--------SHG------------------- 203
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 84370345 275 wrEQKEQRAALMVGILIGVFVLCWFPFFVTELISPLCSWDVPAIWKSIFL--WLGYSNSFFNPLIYTAFNRSY 345
Cdd:cd15088 204 --SSRTKRVTKMVILIVVVFIVCWLPFHVVQLVNLAMNRPTLAFEVAYFLsiCLGYANSCLNPFVYILVSENF 274
7tmA_TAAR5 cd15318
trace amine-associated receptor 5, member of the class A family of seven-transmembrane G ...
58-341 6.41e-20

trace amine-associated receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 5 is one of the 15 identified amine-activated G protein-coupled receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320441 [Multi-domain]  Cd Length: 282  Bit Score: 88.38  E-value: 6.41e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  58 NLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSGRrWQLGRRLCQLWIACDVLCCTASIWNVTAIAL 137
Cdd:cd15318  18 NLFVVVTVSHFKALHTPTNFLLLSLALADMLLGLTVLPFSTIRSVESC-WYFGDSFCRLHTCLDTLFCLTSIFHLCFISI 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 138 DRYWSITRHLEYTLRTRKRVSNVMILLTWALSTVISLAPLlfgwgetYSEPSEE----------CQVSREPSYTVF---S 204
Cdd:cd15318  97 DRHCAICDPLLYPSKFTIRVACIFIAAGWLVPTVYTSVFL-------YTKAVEEglaelltsvpCVGSCQLLYNKLwgwL 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 205 TVGAFYLPLCVVLFVYWKIYRAAKFRmgSRKTNSVSPvpeavEVKNATQHpqmvftvrhatvtfqtegdtwreqkEQRAA 284
Cdd:cd15318 170 NFPVFFIPCLIMIGLYVKIFIVAKRQ--ARAIASLLS-----DTNGASKR-------------------------ERKAA 217
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 84370345 285 LMVGILIGVFVLCWFPFFVTELISPLCSWDVPAIWKSIFLWLGYSNSFFNPLIYTAF 341
Cdd:cd15318 218 KTLGIAVGVYLLCWLPFTIDTMVDSLLNFITPPLLFDIIIWFAYFNSACNPLIYVFS 274
7tmA_Melanopsin cd15336
vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G ...
38-338 2.05e-19

vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G protein-coupled receptors; Melanopsin (also called Opsin-4) is the G protein-coupled photopigment that mediates non-visual responses to light. In mammals, these photoresponses include the photo-entrainment of circadian rhythm, pupillary constriction, and acute nocturnal melatonin suppression. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. Melanopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320458 [Multi-domain]  Cd Length: 290  Bit Score: 87.08  E-value: 2.05e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  38 AFRVLVLTLLGFLAaatftwNLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSgRRWQLGRRLCQLW 117
Cdd:cd15336   4 GSVILIIGITGMLG------NALVIYAFCRSKKLRTPANYFIINLAVSDFLMSLTQSPIFFVNSLH-KRWIFGEKGCELY 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 118 IACDVLCCTASIWNVTAIALDRYWSITRHLEYTLRTRKRVSNVMILLTWALSTVISLAPlLFGWGETYSEP-SEECQ--- 193
Cdd:cd15336  77 AFCGALFGITSMITLLAISLDRYLVITKPLASIRWVSKKRAMIIILLVWLYSLAWSLPP-LFGWSAYVPEGlLTSCTwdy 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 194 VSREPS---YTVFSTVGAFYLPLCVVLFVYWKIYRAakfrmgsrktnsvspvpeaveVKNATQHPQMVFTVRHATVTFQT 270
Cdd:cd15336 156 MTFTPSvraYTMLLFCFVFFIPLGIIIYCYLFIFLA---------------------IRSTGREVQKLGSQDRKEKAKQY 214
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 84370345 271 EgdtwREQKEQRAALMVGILIGVFVLCWFPFFVTELISPLCSWDVPAIW-KSIFLWLGYSNSFFNPLIY 338
Cdd:cd15336 215 Q----RMKNEWKMAKIAFVVILLFVLSWSPYACVALIAWAGYAHLLTPYmKSVPAVIAKASAIYNPIIY 279
7tmA_Adenosine_R_A2A cd15068
adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G ...
41-349 2.13e-19

adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2A receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320196 [Multi-domain]  Cd Length: 293  Bit Score: 86.91  E-value: 2.13e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  41 VLVLTLLGFLAAATFTWNLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVhelsgrrwqLGRRLCQ----- 115
Cdd:cd15068   1 SVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAIT---------ISTGFCAachgc 71
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 116 LWIACDVLCCTAS-IWNVTAIALDRYWSITRHLEYTLRTRKRVSNVMILLTWALSTVISLAPLLfGW------------G 182
Cdd:cd15068  72 LFIACFVLVLTQSsIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPML-GWnncgqpkegknhS 150
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 183 ETYSEPSEECQVSR--EPSYTVFSTVGAFYL-PLCVVLFVYWKIYRAAKFRMgsrKTNSVSPVPEavEVKNATQhpqmvf 259
Cdd:cd15068 151 QGCGEGQVACLFEDvvPMNYMVYFNFFACVLvPLLLMLGVYLRIFLAARRQL---KQMESQPLPG--ERARSTL------ 219
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 260 tvrhatvtfqtegdtwreQKEQRAALMVGILIGVFVLCWFPFFVTELISPLC-SWDVPAIW-KSIFLWLGYSNSFFNPLI 337
Cdd:cd15068 220 ------------------QKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCpDCSHAPLWlMYLAIVLSHTNSVVNPFI 281
                       330
                ....*....|..
gi 84370345 338 YTAFNRSYSSAF 349
Cdd:cd15068 282 YAYRIREFRQTF 293
7tmA_TACR_family cd14992
tachykinin receptor and closely related proteins, member of the class A family of ...
58-349 2.75e-19

tachykinin receptor and closely related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family as well as closely related receptors. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320123 [Multi-domain]  Cd Length: 291  Bit Score: 86.72  E-value: 2.75e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  58 NLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSgRRWQLGRRLCQLWIACDVLCCTASIWNVTAIAL 137
Cdd:cd14992  18 NFIVIAALARHKNLRGATNYFIASLAISDLLMALFCTPFNFTYVVS-LSWEYGHFLCKIVNYLRTVSVYASSLTLTAIAF 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 138 DRYWSITRHLEYTLRTRKRVSNVMILLTWALSTVISLAPLLFGWGET-----------YSEPSEECQVSREPSYTVFSTV 206
Cdd:cd14992  97 DRYFAIIHPLKPRHRQSYTTTVIIIITIWVVSLLLAIPQLYYATTEVlfsvknqekifCCQIPPVDNKTYEKVYFLLIFV 176
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 207 GAFYLPLCVVLFVYWKIyraaKFRMGSRKTNSVSpvpeavevknatqhpqmvftvrhatvtfQTEGDTWREQKEQRAALM 286
Cdd:cd14992 177 VIFVLPLIVMTLAYARI----SRELWFRKVPGFS----------------------------IKEVERKRLKCKRRVIKM 224
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 84370345 287 VGILIGVFVLCWFPFFVTELISPLCSWDVPAI----WKSIFLWLGYSNSFFNPLIYTAFNRSYSSAF 349
Cdd:cd14992 225 LVCVVVLFVICWLPFHLFFLLRDFFPLIMKEKhtlqVYYFLHWIAMSNSMYNPIIYVTLNNNFRKNF 291
7tmA_PSP24-like cd15213
G protein-coupled receptor PSP24 and similar proteins, member of the class A family of ...
78-338 2.83e-19

G protein-coupled receptor PSP24 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes two human orphan receptors, GPR45 and GPR65, and their closely related proteins found in vertebrates and invertebrates. GPR45 and GPR 65 are also called PSP24-alpha (or PSP24-1) and PSP24-beta (or PSP24-2) in other vertebrates, respectively. These receptors exhibit the highest sequence homology to each other. PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Instead, sphingosine 1-phosphate and dioleoylphosphatidic acid have been shown to act as low affinity agonists for GPR63. PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320341 [Multi-domain]  Cd Length: 262  Bit Score: 86.26  E-value: 2.83e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  78 LVASMAISDVLVAVLVMPLSLVHELSGrRWQLGRRLCQLWIACDVLCCTASIWNVTAIALDRYWSITRHLEyTLRTRKrv 157
Cdd:cd15213  38 LLANLAFSDIMLSLVCMPFAAVTIITG-RWIFGDIFCRISAMLYWFFVLEGVAILLIISVDRYLIIVQRQD-KLNPHR-- 113
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 158 SNVMILLTWALSTVISLaPLLFGWGEtYSEPSEECQV-------SREPSYTVFSTVGAFYLPLCVVLFVYWKIYRaakfr 230
Cdd:cd15213 114 AKILIAVSWVLSFCVSF-PPLVGWGK-YEFPPRAPQCvlgytesPADRIYVVLLLVAVFFIPFLIMLYSYFCILN----- 186
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 231 mgsrktnsvspvpeavevknatqhpqmvfTVRHatvtFQTegdtwreqkeqRAALMVGILIGVFVLCWFPFFVTELISPL 310
Cdd:cd15213 187 -----------------------------TVRS----FKT-----------RAFTTILILFIGFSVCWLPYTVYSLLSVF 222
                       250       260
                ....*....|....*....|....*....
gi 84370345 311 CSW-DVPAIWKSIFLWLGYSNSFFNPLIY 338
Cdd:cd15213 223 SRYsSSFYVISTCLLWLSYLKSAFNPVIY 251
7tmA_Opioid_R-like cd14970
opioid receptors and related proteins, member of the class A family of seven-transmembrane G ...
41-338 5.54e-19

opioid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes opioid receptors, somatostatin receptors, melanin-concentrating hormone receptors (MCHRs), and neuropeptides B/W receptors. Together they constitute the opioid receptor-like family, members of the class A G-protein coupled receptors. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and are involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others. G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. MCHR binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Neuropeptides B/W receptors are primarily expressed in the CNS and stimulate the cortisol secretion by activating the adenylate cyclase- and the phospholipase C-dependent signaling pathways.


Pssm-ID: 320101 [Multi-domain]  Cd Length: 282  Bit Score: 85.81  E-value: 5.54e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  41 VLVLTLLGFLAAATFTWNLLVLATILKVRTFHRVPHNLVASMAISDVLVaVLVMPLsLVHELSGRRWQLGRRLCQLWIAC 120
Cdd:cd14970   1 IVIPAVYSVVCVVGLTGNSLVIYVILRYSKMKTVTNIYILNLAVADELF-LLGLPF-LATSYLLGYWPFGEVMCKIVLSV 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 121 DVLCCTASIWNVTAIALDRYWSITRHLEYTLRTRKRVSNVMILLTWALSTVISLAPLLFGWGETYSEPSEEC--QVSREP 198
Cdd:cd14970  79 DAYNMFTSIFCLTVMSVDRYLAVVHPVKSLRFRTPRKAKLVSLCVWALSLVLGLPVIIFARTLQEEGGTISCnlQWPDPP 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 199 SY-----TVFSTVGAFYLPLCVVLFVYWKIYRAAKfrmgsrktnSVSPVPEAvevknatqhpqmvftvrHATVtfqtegd 273
Cdd:cd14970 159 DYwgrvfTIYTFVLGFAVPLLVITVCYSLIIRRLR---------SSRNLSTS-----------------GARE------- 205
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 84370345 274 twREQKEQRAALMVGILIGVFVLCWFPFFVTELISPLCSWDVPAIWKSIFLW---LGYSNSFFNPLIY 338
Cdd:cd14970 206 --KRRARRKVTRLVLVVVAVFVVCWLPFHVFQIVRLLIDPPETLTVVGVFLFciaLSYANSCLNPILY 271
7tmA_Histamine_H3R cd15296
histamine receptor subtypes H3R and H3R-like, member of the class A family of ...
41-349 8.09e-19

histamine receptor subtypes H3R and H3R-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H3R-like, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320423 [Multi-domain]  Cd Length: 271  Bit Score: 84.84  E-value: 8.09e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  41 VLVLTLLGFLAAATFTWNLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSGRrWQLGRRLCQLWIAC 120
Cdd:cd15296   1 VILAVLMALLVVATVLGNALVILAFVVDSSLRTQGNFFFLNLAISDFLVGGFCIPLYIPYVLTGR-WKFGRGLCKLWLVV 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 121 DVLCCTASIWNVTAIALDRYWSITRHLEYTLRTRKRVSNVMILLTWALSTVISLAPLLFGW---GETYSEPSEECQVsrE 197
Cdd:cd15296  80 DYLLCTASVFNIVLISYDRFLSVTRAVSYRAQKGMTRQAVLKMVLVWVLAFLLYGPAIISWeyiAGGSIIPEGECYA--E 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 198 PSYTVFSTVGA----FYLPLCVVLFVYWKIYRAAKFRmgsrktnsvspvpeavevknatqhpqmvftvrhatvtfqtegd 273
Cdd:cd15296 158 FFYNWYFLMTAstleFFTPFISVTYFNLSIYLNIQKR------------------------------------------- 194
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 84370345 274 TWREQKEQRAALMVGILIGVFVLCWFPFFVTELISPLCSWD-VPAIWKSIFLWLGYSNSFFNPLIYTAFNRSYSSAF 349
Cdd:cd15296 195 RFRLSRDKKVAKSLAIIVCVFGLCWAPYTLLMIIRAACHGHcVPDYWYETSFWLLWVNSAINPVLYPLCHMSFRRAF 271
7tmA_Opsin5_neuropsin cd15074
neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled ...
44-345 8.56e-19

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropsin, also known as Opsin-5, is a photoreceptor protein expressed in the retina, brain, testes, and spinal cord. Neuropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Mammalian neuropsin activates Gi protein-mediated photo-transduction pathway in a UV-dependent manner, whereas, in non-mammalian vertebrates, neuropsin is involved in regulating the photoperiodic control of seasonal reproduction in birds such as quail. As with other opsins, it may also act as a retinal photoisomerase.


Pssm-ID: 320202 [Multi-domain]  Cd Length: 284  Bit Score: 85.02  E-value: 8.56e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  44 LTLLGFLAaatFTWNLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSGrRWQLGRRLCQLWIACDVL 123
Cdd:cd15074   7 LTVIGILS---TLGNGTVLFVLYRRRSKLKPAELLTVNLAVSDLGISVFGYPLAIISAFAH-RWLFGDIGCVFYGFCGFL 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 124 CCTASIWNVTAIALDRYWSITrHLEYTLRTRKRVSNVMILLTWALSTVISLAPlLFGWGETYSEP-SEECQV-------- 194
Cdd:cd15074  83 FGCCSINTLTAISIYRYLKIC-HPPYGPKLSRRHVCIVIVAIWLYALFWAVAP-LVGWGSYGPEPfGTSCSIdwtgasas 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 195 SREPSYTVFSTVGAFYLPLCVVLFVYWKIYRaakfrmgsrktnsvspvpeavevknatqhpqmvfTVRHATVTFQTEGDT 274
Cdd:cd15074 161 VGGMSYIISIFIFCYLLPVLIIVFSYVKIIR----------------------------------KVKSSRKRVAGFDSR 206
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 84370345 275 WREQK--EQRAALMVGILIGVFVLCWFPFFVTELISPLCSWD-VPAIWKSIFLWLGYSNSFFNPLIYTAFNRSY 345
Cdd:cd15074 207 SKRQHkiERKVTKVAVLICAGFLIAWTPYAVVSMWSAFGSPDsVPILASILPALFAKSSCMYNPIIYLLFSSKF 280
7tmA_NTSR-like cd14979
neurotensin receptors and related G protein-coupled receptors, member of the class A family of ...
41-349 9.19e-19

neurotensin receptors and related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the neurotensin receptors and related G-protein coupled receptors, including neuromedin U receptors, growth hormone secretagogue receptor, motilin receptor, the putative GPR39 and the capa receptors from insects. These receptors all bind peptide hormones with diverse physiological effects. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320110 [Multi-domain]  Cd Length: 300  Bit Score: 85.48  E-value: 9.19e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  41 VLVLTLLGFLAAATFTWNLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSGRRWQLGRRLCQLWIAC 120
Cdd:cd14979   1 VLVTAIYVAIFVVGIVGNLLTCIVIARHKSLRTTTNYYLFSLAVSDLLILLVGLPVELYNFWWQYPWAFGDGGCKLYYFL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 121 DVLCCTASIWNVTAIALDRYWSITRHLE-YTLRTRKRVSNVmILLTWALSTVISLaPLLFGWGETY--------SEPSEE 191
Cdd:cd14979  81 FEACTYATVLTIVALSVERYVAICHPLKaKTLVTKRRVKRF-ILAIWLVSILCAI-PILFLMGIQYlngplpgpVPDSAV 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 192 CQVSREPS----YTVFSTVGAFYLPLCVVLFVYwkiyraakFRMGSR-KTNSVSPVPEAVEVKNATQHPQmvftvrhatv 266
Cdd:cd14979 159 CTLVVDRStfkyVFQVSTFIFFVLPMFVISILY--------FRIGVKlRSMRNIKKGTRAQGTRNVELSL---------- 220
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 267 tfqtegdtwREQKEQRAALMVGILIGVFVLCWFPFFVTELISPLCS-WDVPAIWKSIFLW-----LGYSNSFFNPLIYTA 340
Cdd:cd14979 221 ---------SQQARRQVVKMLGAVVIAFFVCWLPFHAQRLMFSYASkEDTFLFDFYQYLYpisgiLFYLSSAINPILYNL 291

                ....*....
gi 84370345 341 FNRSYSSAF 349
Cdd:cd14979 292 MSSRFRVAF 300
7tmA_AKHR cd15382
adipokinetic hormone receptor, member of the class A family of seven-transmembrane G ...
41-343 1.46e-18

adipokinetic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flight, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. AKH is structurally related to the mammalian gonadotropin-releasing hormone (GnRH) and they share a common ancestor. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320504 [Multi-domain]  Cd Length: 298  Bit Score: 84.67  E-value: 1.46e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  41 VLVLTLLGFLAAATFTWNLLVLATILKVR--TFHRVpHNLVASMAISDVLVAVLVMPLSLVHELSgRRWQLGRRLCQLWI 118
Cdd:cd15382   1 LVSIIVYSVLFLIAAVGNLTVLLILLRNRrrKRSRV-NILLMHLAIADLLVTFIMMPLEIGWAAT-VAWLAGDFLCRLML 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 119 ACDVLCCTASIWNVTAIALDRYWSITRHLeYTLRTRKRVSNvMILLTWALSTVISLAPLLFGWGETYSEPS--EECqVS- 195
Cdd:cd15382  79 FFRAFGLYLSSFVLVCISLDRYFAILKPL-RLSDARRRGRI-MLAVAWVISFLCSIPQSFIFHVESHPCVTwfSQC-VTf 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 196 -------REPSYTVFSTVGAFYLPLCVVLFVY----WKIYRAAKfrmgsrktnsvspvpeavEVKNATQHPQMVFTVRHA 264
Cdd:cd15382 156 nffpshdHELAYNIFNMITMYALPLIIIVFCYslilCEISRKSK------------------EKKEDVSEKSSSVRLRRS 217
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 265 TVTFQtegdtwrEQKEQRAALMVGILIGVFVLCWFPFFVTEL----ISPLCSWDVPAIWKSIFLwLGYSNSFFNPLIYTA 340
Cdd:cd15382 218 SVGLL-------ERARSRTLKMTIVIVLVFIICWTPYFIMSLwywfDRESASKVDPRIQKGLFL-FAVSNSCMNPIVYGY 289

                ...
gi 84370345 341 FNR 343
Cdd:cd15382 290 FSI 292
7tmA_leucokinin-like cd15393
leucokinin-like peptide receptor from tick and related proteins, member of the class A family ...
58-349 1.66e-18

leucokinin-like peptide receptor from tick and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a leucokinin-like peptide receptor from the Southern cattle tick, Boophilus microplus, a pest of cattle world-wide. Leucokinins are invertebrate neuropeptides that exhibit myotropic and diuretic activity. This receptor is the first neuropeptide receptor known from the Acari and the second known in the subfamily of leucokinin-like peptide G-protein-coupled receptors. The other known leucokinin-like peptide receptor is a lymnokinin receptor from the mollusc Lymnaea stagnalis.


Pssm-ID: 320515 [Multi-domain]  Cd Length: 288  Bit Score: 84.38  E-value: 1.66e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  58 NLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSgRRWQLGRRLCQLWIACDVLCCTASIWNVTAIAL 137
Cdd:cd15393  18 NFLVIWVVAKNRRMRTVTNIFIANLAVADIIIGLFSIPFQFQAALL-QRWVLPRFMCPFCPFVQVLSVNVSVFTLTVIAV 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 138 DRYWSITRHLEYtlRTRKRVSNVMILLTWALSTVISLAPLLFGWGETYSEPSEECQVSR----------EPSYTVFSTVG 207
Cdd:cd15393  97 DRYRAVIHPLKA--RCSKKSAKIIILIIWILALLVALPVALALRVEELTDKTNNGVKPFclpvgpsddwWKIYNLYLVCV 174
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 208 AFYLPLCVVLFVYWKIyraAKFRMGSRKTNSVSPVPEAVEVKNatqhpqmvftvrhatvtfqtegdtwreqkEQRAALMV 287
Cdd:cd15393 175 QYFVPLVIICYAYTRI---AVKIWGTKAPGNAQDVRDDEILKN-----------------------------KKKVIKML 222
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 288 GILIGVFVLCWFPFFVTELISPLcswdVPAI--WKSIFL------WLGYSNSFFNPLIYTAFNRSYSSAF 349
Cdd:cd15393 223 IIVVALFALCWLPLQTYNLLNEI----KPEInkYKYINIiwfcshWLAMSNSCYNPFIYGLYNEKFKREF 288
7tmA_Vasopressin-like cd14986
vasopressin receptors and its related G protein-coupled receptors, member of the class A ...
47-342 3.99e-18

vasopressin receptors and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this group form a subfamily within the class A G-protein coupled receptors (GPCRs), which includes the vasopressin and oxytocin receptors, the gonadotropin-releasing hormone receptors (GnRHRs), the neuropeptide S receptor (NPSR), and orphan GPR150. These receptors share significant sequence homology with each other, suggesting that they have a common evolutionary origin. Vasopressin, also known as arginine vasopressin or anti-diuretic hormone, is a neuropeptide synthesized in the hypothalamus. The actions of vasopressin are mediated by the interaction of this hormone with three tissue-specific subtypes: V1AR, V1BR, and V2R. Although vasopressin differs from oxytocin by only two amino acids, they have divergent physiological functions. Vasopressin is involved in regulating osmotic and cardiovascular homeostasis, whereas oxytocin plays an important role in the uterus during childbirth and in lactation. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR has also been associated with asthma and allergy. GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors.


Pssm-ID: 320117 [Multi-domain]  Cd Length: 295  Bit Score: 83.58  E-value: 3.99e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  47 LGFLAAATFTWNLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSGrRWQLGRRLCQLWIACDVLCCT 126
Cdd:cd14986   7 LGVLFVFTLVGNGLVILVLRRKRKKRSRVNIFILNLAIADLVVAFFTVLTQIIWEATG-EWVAGDVLCRIVKYLQVVGLF 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 127 ASIWNVTAIALDRYWSITRHLEyTLRTRKRVsNVMILLTWALSTVISLAPLLFGWGETYSEPSEECQVS--REPSYTVFS 204
Cdd:cd14986  86 ASTYILVSMSLDRYQAIVKPMS-SLKPRKRA-RLMIVVAWVLSFLFSIPQLVIFVERELGDGVHQCWSSfyTPWQRKVYI 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 205 TVGAFYL---PLCVVLFVYWKIYRAAkfrmgSRKTNSVSPVPEAVEVKNATQHPQMVFTVRHAtvtfqtegdtwrEQKEQ 281
Cdd:cd14986 164 TWLATYVfviPLIILSYCYGRILRTI-----WIRSRQKTDRPIAPTAMSCRSVSCVSSRVSLI------------SRAKI 226
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 84370345 282 RAALMVGILIGVFVLCWFPFFVTELisplcsWDVPAIWK-------SIFLWLGYSNSFFNPLIYTAFN 342
Cdd:cd14986 227 KTIKMTLVIILAFILCWTPYFIVQL------LDVYAGMQqlendayVVSETLASLNSALNPLIYGFFS 288
7tmA_GPR101 cd15215
orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G ...
44-349 7.90e-18

orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G protein-coupled receptors; Gpr101, an orphan GPCR, is predominantly expressed in the brain within discrete nuclei and is predicted to couple to the stimulatory G(s) protein, a potent activator of adenylate cyclase. GPR101 has been implicated in mediating the actions of GnRH-(1-5), a pentapeptide formed by metallopeptidase cleavage of the decapeptide gonadotropin-releasing hormone (GnRH), which plays a critical role in the regulation of the hypothalamic-pituitary-gonadal axis. GnRH-(1-5) acts on GPR101 to stimulate epidermal growth factor (EFG) release and EFG-receptor (EGFR) phosphorylation, leading to enhanced cell migration and invasion in the Ishikawa endometrial cancer cell line. Furthermore, these effects of GnRH-(1-5) are also dependent on enzymatic activation of matrix metallopeptidase-9 (MMP-9). GPR101 is a member of the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320343 [Multi-domain]  Cd Length: 261  Bit Score: 82.20  E-value: 7.90e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  44 LTLLGFLAAATFTWNLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSgRRWQLGRRLCQLWIACDVL 123
Cdd:cd15215   3 SVLIVIFLCASLFGNIVLLLVFQRKPQLLQVANRFIFNLLVADLLQTVLVMPWVIATSVP-LFWPLDSHLCTALVVLMHL 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 124 CCTASIWNVTAIALDRYWSITRHLEYTLRTRKRVSNVMILLTWALSTVISLAPlLFGWGET-YSEPSEECQV--SREPSY 200
Cdd:cd15215  82 FAFAGVNTIVVVSVDRYLAIIHPLSYPTKMTPRRGYLLIYGTWIVSVLQSTPP-LYGWGQAaFDERNALCSViwGSSYSY 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 201 TVFSTVGAFYLPLCVVLFVYWKIYRAAkfrmgsrktnsvspvpeavevknatqhpqmvftvrhatvtfqtegdtwREQKE 280
Cdd:cd15215 161 TILSVVSSFVLPVIIMLACYSMVFRAA------------------------------------------------RRCYH 192
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 84370345 281 QRAALMVGILIGVFVLCWFPFFVTELISPLCSWDVPAIWKSIFLWLGYSNSFFNPLIYTAFNRSYSSAF 349
Cdd:cd15215 193 CKAAKVIFIIIFSYVLSMGPYSFLSVLAVWVDTQVPQWVISIILWLFFLQCCIHPYIYGYMHKSIKKEF 261
7tmA_Vasopressin_Oxytocin cd15196
vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G ...
41-349 1.44e-17

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) and oxytocin are synthesized in the hypothalamus and are released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320324 [Multi-domain]  Cd Length: 264  Bit Score: 81.51  E-value: 1.44e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  41 VLVLTLLGflaaatftwNLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELsGRRWQLGRRLCQLWIAC 120
Cdd:cd15196  10 ILVLALFG---------NSCVLLVLYRRRRKLSRMHLFILHLSVADLLVALFNVLPQLIWDI-TYRFYGGDLLCRLVKYL 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 121 DVLCCTASIWNVTAIALDRYWSITRHLEYTLRTRKRVsNVMILLTWALSTVISLaPLLFGWgeTYSEPSE---ECQVSRE 197
Cdd:cd15196  80 QVVGMYASSYVLVATAIDRYIAICHPLSSHRWTSRRV-HLMVAIAWVLSLLLSI-PQLFIF--SYQEVGSgvyDCWATFE 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 198 PS-----YTVFSTVGAFYLPLCVVLFVYWKIYRAakfrMGSRKTNSVspvpeavevknatqhpQMVFTVrhatvtfqteg 272
Cdd:cd15196 156 PPwglraYITWFTVAVFVVPLIILAFCYGRICYV----VWRAKIKTV----------------KLTLVV----------- 204
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 273 dtwreqkeqraalmvgilIGVFVLCWFPFFVTELISplcSWDVPAIWKS----IFLWLGYSNSFFNPLIYTAFNRSYSSA 348
Cdd:cd15196 205 ------------------VACYIVCWTPFFVVQMWA---AWDPTAPIEGpafvIIMLLASLNSCTNPWIYLAFSGNLRRA 263

                .
gi 84370345 349 F 349
Cdd:cd15196 264 L 264
7tmA_NPY2R cd15399
neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G ...
58-349 1.97e-17

neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320521 [Multi-domain]  Cd Length: 285  Bit Score: 81.40  E-value: 1.97e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  58 NLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSGRrWQLGRRLCQLWIACDVLCCTASIWNVTAIAL 137
Cdd:cd15399  18 NSLVIYVVIKFKNMRTVTNFFIANLAVADLMVNTLCLPFTLVYTLLDE-WKFGAVLCHLVPYAQALAVHVSTVTLTVIAL 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 138 DRYWSITRHLEYtlRTRKRVSNVMILLTWALSTVISLAPLLFgwgETYS----EPSEECQVSRE--PS--------YTVF 203
Cdd:cd15399  97 DRHRCIVYHLES--KISKKISFLIIGLTWAASALLASPLAIF---REYSvieiSPDFKIQACSEkwPNgtlndgtiYSVS 171
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 204 STVGAFYLPLCVVLFVYWKIYRAAKfrmgsrktNSVSPvpeavevknatqhpqmvftvrhatvtfqTEGDTWREQKEQRA 283
Cdd:cd15399 172 MLLIQYVLPLAIISYAYIRIWTKLK--------NHVSP----------------------------GGGNDHYHQRRRKT 215
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 284 ALMVGILIGVFVLCWFPFFVTELISPLCS----WDVPAIWKSIFLWLGYSNSFFNPLIYTAFNRSYSSAF 349
Cdd:cd15399 216 TKMLVCVVVVFAVSWLPFHAFQLASDIDSkvldLKEYKLIYTIFHVIAMCSTFANPLLYGWMNNNYRTAF 285
7tmA_NPR-like_invertebrate cd15391
invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G ...
58-347 3.21e-17

invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor found in invertebrates, which is a member of class A of 7-transmembrane G protein-coupled receptors. This orphan receptor shares a significant amino acid sequence identity with the neurokinin 1 receptor (NK1R). The endogenous ligand for NK1R is substance P, an 11-amino acid peptide that functions as a vasodilator and neurotransmitter and is released from the autonomic sensory nerve fibers.


Pssm-ID: 320513 [Multi-domain]  Cd Length: 289  Bit Score: 80.64  E-value: 3.21e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  58 NLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSGRrWQLGRRLCQLWIACDVLCCTASIWNVTAIAL 137
Cdd:cd15391  18 NYSVIVVFYDGRRSRTDLNYYLINLAVSDLIMALFCMPFTFTQIMLGH-WVFPAPMCPIVLYVQLVSVTASVLTNTAIGI 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 138 DRYWSITRHLEYtlRTRKRVSNVMILLTWALSTVISLAPLLFGWGETYSEPSE---ECQ------VSREPSYTVFSTVGA 208
Cdd:cd15391  97 DRFFAVIFPLRS--RHTKSRTKCIIASIWAISFSLSSVQLFAGRTQRYGQYSEgrvLCGeswpgpDTSRSAYTVFVMLLT 174
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 209 FYLPLCVVLFVYWKIyraaKFRMGSRKTNSvspvpEAVEVKNATQHpqmvftvrhatvtfqtegdtwreQKEQRAALMVG 288
Cdd:cd15391 175 YIIPLLILTSTYGYV----GFRLWNRTAPG-----NADKGRDDMQI-----------------------KSKRKVIKMLV 222
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 84370345 289 ILIGVFVLCWFP---FFVTELISPLCSWDVPAIWKSIFL---WLGYSNSFFNPLIYTAFNRSYSS 347
Cdd:cd15391 223 FVVLMFGICWLPlhlFNLVQDFSTVFRNMPQHTTRLIYGachWIAMSNSFVNPIIYLFMNDSFRS 287
7tmA_Adenosine_R_A2B cd15069
adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G ...
50-349 7.55e-17

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2B receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320197 [Multi-domain]  Cd Length: 294  Bit Score: 79.98  E-value: 7.55e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  50 LAAATFTWNLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSgrrWQLGRRLCqLWIACDVLCCT-AS 128
Cdd:cd15069  10 IAALSVAGNVLVCAAVGTNSTLQTPTNYFLVSLAAADVAVGLFAIPFAITISLG---FCTDFHSC-LFLACFVLVLTqSS 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 129 IWNVTAIALDRYWSITRHLEY-TLRTRKRVSNVMILLtWALSTVISLAPLLfGWGETYSEpseeCQVSREP--------- 198
Cdd:cd15069  86 IFSLLAVAVDRYLAIKVPLRYkSLVTGKRARGVIAVL-WVLAFGIGLTPFL-GWNKAMSA----TNNSTNPadhgtnhsc 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 199 -------------SYTV-FSTVGAFYLPLCVVLFVYWKIYRAakfrmgsrktnsvspvpeavevknATQHPQMVFTVRHA 264
Cdd:cd15069 160 clisclfenvvpmSYMVyFNFFGCVLPPLLIMLVIYIKIFLV------------------------ACRQLQRTELMDHS 215
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 265 TVTFqtegdtwreQKEQRAALMVGILIGVFVLCWFPFFVTELIS---PLCSWDVPAIWKSIFLWLGYSNSFFNPLIYTAF 341
Cdd:cd15069 216 RTTL---------QREIHAAKSLAIIVGIFALCWLPVHILNCITlfqPEFSKSKPKWAMNVAILLSHANSVVNPIVYAYR 286

                ....*...
gi 84370345 342 NRSYSSAF 349
Cdd:cd15069 287 NRDFRYTF 294
7tmA_SREB-like cd15005
super conserved receptor expressed in brain and related proteins, member of the class A family ...
41-343 1.05e-16

super conserved receptor expressed in brain and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320134 [Multi-domain]  Cd Length: 329  Bit Score: 79.81  E-value: 1.05e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  41 VLVLTLLGFLAAATFTWNLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSGRRWQLGRRLCQLWIAC 120
Cdd:cd15005   1 ALKLTTLGLILCVSLAGNLLFSVLIVRDRSLHRAPYYFLLDLCLADGLRSLACFPFVMASVRHGSGWIYGALSCKVIAFL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 121 DVLCCTASIWNVTAIALDRYWSITRHLEYTLRTRKRVSNVMILLTWALSTVISLAPLLFGWGETYSEPSEECQVSREpSY 200
Cdd:cd15005  81 AVLFCFHSAFTLFCIAVTRYMAIAHHRFYAKRMTFWTCLAVICMAWTLSVAMAFPPVFDVGTYTFIREEDQCTFEHR-SY 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 201 TVFSTVGaFYLPLCVVLFVYWKIY-RAAKFRMGSRKTNSVSPVPEAVEvkNATQH----------------------PQM 257
Cdd:cd15005 160 KANDTLG-FMLVLAVVIAATHLVYlKLLIFLRHHRKMKPAQLVPAISQ--NWTFHgpgatgqaaanwtagfgrgptpPTL 236
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 258 VFTVRHATVTFQTEGDTWREQKEQRAALMVGILIGVFVLCWFPFFVTELISPLC-SWDVPAIWKSIFLWLGYSNSFFNPL 336
Cdd:cd15005 237 LGIRQAFHSGARRLLVLDEFKMEKRLTRMFYAITLLFLLLWSPYIVACYIRVFVrGYAVPQGFLTAAVWMTFAQAGVNPI 316

                ....*..
gi 84370345 337 IYTAFNR 343
Cdd:cd15005 317 VCFFFNR 323
7tmA_SSTR1 cd15970
somatostatin receptor type 1, member of the class A family of seven-transmembrane G ...
58-349 2.35e-16

somatostatin receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR1 is coupled to a Na/H exchanger, voltage-dependent calcium channels, and AMPA/kainate glutamate channels. SSTR1 is expressed in the normal human pituitary and in nearly half of all pituitary adenoma subtypes.


Pssm-ID: 320636 [Multi-domain]  Cd Length: 276  Bit Score: 78.03  E-value: 2.35e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  58 NLLVLATILKVRTFHRVPHNLVASMAISDVLVaVLVMPLsLVHELSGRRWQLGRRLCQLWIACDVLCCTASIWNVTAIAL 137
Cdd:cd15970  18 NSMVIYVILRYAKMKTATNIYILNLAIADELL-MLSVPF-LVTSTLLRHWPFGSLLCRLVLSVDAINMFTSIYCLTVLSI 95
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 138 DRYWSITRHLEYTLRTRKRVSNVMILLTWALSTVISLAPLLFGWGETYSEPSEECQVSR-EPS------YTVFSTVGAFY 210
Cdd:cd15970  96 DRYIAVVHPIKAARYRRPTVAKMVNLGVWVFSILVILPIIIFSNTAPNSDGSVACNMQMpEPSqrwlavFVVYTFLMGFL 175
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 211 LPLCVVLFVYwkIYRAAKFRMgsrktnsvspvpeaVEVKNATQHpqmvftvrhatvtfqtegdtwREQKEQRAALMVGIL 290
Cdd:cd15970 176 LPVIAICLCY--ILIIVKMRV--------------VALKAGWQQ---------------------RKRSERKITLMVMMV 218
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 84370345 291 IGVFVLCWFPFFVTELISPLCSWDVPAIwKSIFLWLGYSNSFFNPLIYTAFNRSYSSAF 349
Cdd:cd15970 219 VTVFVICWMPFYVVQLVSVFVGQHDATV-SQLSVILGYANSCANPILYGFLSDNFKRSF 276
7tmA_MCHR2 cd15339
melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane ...
45-345 5.10e-16

melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320461 [Multi-domain]  Cd Length: 283  Bit Score: 77.16  E-value: 5.10e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  45 TLLGFLAAATFTWNLLVLATILKVRTfHRVPHNLVASMAISDvLVAVLVMPLsLVHELS-GRRWQLGRRLCQLWIACDVL 123
Cdd:cd15339   5 SFIGILCSTGLVGNILVLFTIIRSRK-KTVPDIYVCNLAVAD-LVHIIVMPF-LIHQWArGGEWVFGSPLCTIITSLDTC 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 124 CCTASIWNVTAIALDRYWSITRHLEYT-LRTRKRVSNVMILLtWALSTVISLAPLLFGWGETYSEPSEECQVSREPS--- 199
Cdd:cd15339  82 NQFACSAIMTAMSLDRYIALVHPFRLTsLRTRSKTIRINLLV-WAASFILVLPVWVYAKVIKFRDGLESCAFNLTSPddv 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 200 --YTVFSTVGAFYLPLCVVLFVY-------WKIYRaaKFRMGSRKTNSVSpvpeavevknatqhpqmvftvrhatvtfqt 270
Cdd:cd15339 161 lwYTLYQTITTFFFPLPLILICYililcytWEMYR--KNKKAGRYNTSIP------------------------------ 208
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 84370345 271 egdtwrEQKEQRAALMVGILIGVFVLCWFPFFVTELISPLCSWDVPAIWKSIFL--WLGYSNSFFNPLIYTAFNRSY 345
Cdd:cd15339 209 ------RQRVMRLTKMVLVLVGVFLVSAAPYHVIQLVNLSVSQPTLAFYVSYYLsiCLSYASSSINPFLYILLSGNF 279
7tmA_TACR-like cd15202
tachykinin receptors and related receptors, member of the class A family of ...
41-349 6.03e-16

tachykinin receptors and related receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the neurokinin/tachykinin receptors and its closely related receptors such as orphan GPR83 and leucokinin-like peptide receptor. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320330 [Multi-domain]  Cd Length: 288  Bit Score: 77.16  E-value: 6.03e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  41 VLVLTLLGFLAAATFTWNLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSgRRWQLGRRLCQLWIAC 120
Cdd:cd15202   1 VLLIVAYSFIIVFSLFGNVLVCWIIFKNQRMRTVTNYFIVNLAVADIMITLFNTPFTFVRAVN-NTWIFGLFMCHFSNFA 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 121 DVLCCTASIWNVTAIALDRYWSITRHLEytLRTRKRVSNVMILLTWALSTVISLAPLLFGWGETYSEPSE---------- 190
Cdd:cd15202  80 QYCSVHVSAYTLTAIAVDRYQAIMHPLK--PRISKTKAKFIIAVIWTLALAFALPHAICSKLETFKYSEDivrslcledw 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 191 -ECQVSREPSYTVFSTVGAFYLPLCVVLFVYwkiyraakFRMGSRKTNSVSPvpeavevKNAtqhpqmvftvrhatvtfQ 269
Cdd:cd15202 158 pERADLFWKYYDLALFILQYFLPLLVISFAY--------ARVGIKLWASNMP-------GDA-----------------T 205
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 270 TEGDTWREQKEQRAALMVGILIGVFVLCWFPFFVTEL---ISPLCSWD-VPAIWKSiFLWLGYSNSFFNPLIYTAFNRSY 345
Cdd:cd15202 206 TERYFALRRKKKKVIKMLMVVVVLFALCWLPFNIYVLllsSKPDYLIKtINAVYFA-FHWLAMSSTCYNPFIYCWLNERF 284

                ....
gi 84370345 346 SSAF 349
Cdd:cd15202 285 RIEF 288
7tmA_GPR84-like cd15210
G protein-coupled receptor 84 and similar proteins, member of the class A family of ...
58-349 9.68e-16

G protein-coupled receptor 84 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR84, also known as the inflammation-related G-Protein coupled receptor EX33, is a receptor for medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Among these medium-chain FFAs, capric acid (C10:0), undecanoic acid (C11:0), and lauric acid (C12:0) are the most potent endogenous agonists of GPR84, whereas short-chain and long-chain saturated and unsaturated FFAs do not activate this receptor. GPR84 contains a [G/N]RY-motif instead of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors and important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. In the case of GPR84, activation of the receptor couples to a pertussis toxin sensitive G(i/o)-protein pathway. GPR84 knockout mice showed increased Th2 cytokine production including IL-4, IL-5, and IL-13 compared to wild-type mice. It has been also shown that activation of GPR84 augments lipopolysaccharide-stimulated IL-8 production in polymorphonuclear leukocytes and TNF-alpha production in macrophages, suggesting that GPR84 may function as a proinflammatory receptor.


Pssm-ID: 320338 [Multi-domain]  Cd Length: 254  Bit Score: 75.76  E-value: 9.68e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  58 NLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSgRRWQLGRRLCQLWIACDVLCCTASIWNVTAIAL 137
Cdd:cd15210  18 NLLTVLALLRSKKLRTRTNAFIINLSISDLLFCAFNLPLAASTFLH-QAWIHGETLCRVFPLLRYGLVAVSLLTLVLITL 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 138 DRYWSITRHLEYTLRTRKRVSNVMILLTWALSTVISLAPLLFGWGETYSEPS-EECQVSRE---PSYTVFSTVGAFYLPL 213
Cdd:cd15210  97 NRYILIAHPSLYPRIYTRRGLALMIAGTWIFSFGSFLPLWLGIWGRFGLDPKvCSCSILRDkkgRSPKTFLFVFGFVLPC 176
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 214 CVVLFVYWKiyraakfrmgsrktnsvspvpeavevknatqhpqmvftvrhatvtfqtegdtwreQKEQRAALMVGILIGV 293
Cdd:cd15210 177 LVIIICYAR-------------------------------------------------------REDRRLTRMMLVIFLC 201
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 84370345 294 FVLCWFPFFVTELISPLCSWDVPAIWKSIFLWLgysNSFFNPLIYTAFNRSYSSAF 349
Cdd:cd15210 202 FLVCYLPITLVNVFDDEVAPPVLHIIAYVLIWL---SSCINPIIYVAMNRQYRQAY 254
7tmA_PrRP_R cd15394
prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
42-345 2.28e-15

prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prolactin-releasing peptide (PrRP) receptor (previously known as GPR10) is expressed in the central nervous system with the highest levels located in the anterior pituitary and is activated by its endogenous ligand PrRP, a neuropeptide possessing a C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acids (PrRP-20) and the other consists of 31 amino acids (PrRP-31), where PrRP-20 is a C-terminal fragment of PrRP-31. Binding of PrRP to the receptor coupled to G(i/o) proteins activates the extracellular signal-related kinase (ERK) and it can also couple to G(q) protein leading to an increase in intracellular calcium and activation of c-Jun N-terminal protein kinase (JNK). The PrRP receptor shares significant sequence homology with the neuropeptide Y (NPY) receptor, and micromolar levels of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors. PrRP has been shown to reduce food intake and body weight and modify body temperature when administered in rats. It also has been shown to decrease circulating growth hormone levels by activating somatostatin-secreting neurons in the hypothalamic periventricular nucleus.


Pssm-ID: 320516 [Multi-domain]  Cd Length: 286  Bit Score: 75.55  E-value: 2.28e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  42 LVLTLLGFLAAATFTWNLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSGRRWQLGRRLCQLWIACD 121
Cdd:cd15394   2 LIIPLYSLVVLVGVVGNYLLIYVICRTKKMHNVTNFLIGNLAFSDMLMCATCVPLTLAYAFEPRGWVFGRFMCYFVFLMQ 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 122 VLCCTASIWNVTAIALDRYWSITrhleYTLRTR--KRVSNVMILLTWALSTVISLAPLLFGWGETYSEPS----EECQVS 195
Cdd:cd15394  82 PVTVYVSVFTLTAIAVDRYYVTV----YPLRRRisRRTCAYIVAAIWLLSCGLALPAAAHTYYVEFKGLDfsicEEFWFG 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 196 REPS---YTVFSTVGAFYLPLCVVLFVYWKIyrAAKFRmgsrktNSVSPvpeavevknatqhpqmvftvRHATvtfQTEG 272
Cdd:cd15394 158 QEKQrlaYACSTLLITYVLPLLAISLSYLRI--SVKLR------NRVVP--------------------GSMT---QSQA 206
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 273 DTWREQKEQRAALMVgILIGVFVLCWFPFFVTELISPLcswDVPAIWKSIF-------LWLGYSNSFFNPLIYTAFNRSY 345
Cdd:cd15394 207 EWDRARRRKTFRLLV-VVVVAFAICWLPLHIFNVIRDI---DIDLIDKQYFnliqllcHWLAMSSACYNPFLYAWLHDSF 282
7tmA_GPRnna14-like cd15001
GPRnna14 and related proteins, member of the class A family of seven-transmembrane G ...
58-349 2.46e-15

GPRnna14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the orphan G-protein coupled receptor GPRnna14 found in body louse (Pediculus humanus humanus) as well as its closely related proteins of unknown function. These receptors are members of the class A rhodopsin-like G-protein coupled receptors. As an obligatory parasite of humans, the body louse is an important vector for human diseases, including epidemic typhus, relapsing fever, and trench fever. GPRnna14 shares significant sequence similarity with the members of the neurotensin receptor family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320132 [Multi-domain]  Cd Length: 266  Bit Score: 75.00  E-value: 2.46e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  58 NLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSGrRWQLGRRLCQLWIACDVLCCTASIWNVTAIAL 137
Cdd:cd15001  17 NSLVIFVVARFRRMRSVTNVFLASLATADLLLLVFCVPLKTAEYFSP-TWSLGAFLCKAVAYLQLLSFICSVLTLTAISI 95
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 138 DRYWSITRHLE-YTLRTRKRVSNVmILLTWALSTVISlAPLLFGWG-ETYSEPSEECQVSREPSYTVFSTVGAFYLPLCV 215
Cdd:cd15001  96 ERYYVILHPMKaKSFCTIGRARKV-ALLIWILSAILA-SPVLFGQGlVRYESENGVTVYHCQKAWPSTLYSRLYVVYLAI 173
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 216 VLFVywkiyraakfrmgsrktnsvspVPEAVevknatqhpqMVFTVRhatvtfqtegdtwREQKEQRAALMVGILIgVFV 295
Cdd:cd15001 174 VIFF----------------------IPLIV----------MTFAYA-------------RDTRKQVIKMLISVVV-LFA 207
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 84370345 296 LCWFPFFVTELISP---LCSWDVPA--IWKSIFLWLGYSNSFFNPLIYTAFNRSYSSAF 349
Cdd:cd15001 208 VCWGPLLIDNLLVSfdvISTLHTQAlkYMRIAFHLLSYANSCINPIIYAFMSKNFRSSF 266
7tmA_purinoceptor-like cd14982
purinoceptor and its related proteins, member of the class A family of seven-transmembrane G ...
41-338 2.62e-15

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this subfamily include lysophosphatidic acid receptor, P2 purinoceptor, protease-activated receptor, platelet-activating factor receptor, Epstein-Barr virus induced gene 2, proton-sensing G protein-coupled receptors, GPR35, and GPR55, among others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341318 [Multi-domain]  Cd Length: 283  Bit Score: 74.99  E-value: 2.62e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  41 VLVLTLLGFLAAatftwnLLVLATILKVRTFHRVphnLVASMAISDVLVaVLVMPLSLVHELSGRRWQLGRRLCQLWIAC 120
Cdd:cd14982  10 IFILGLLGNILA------LWVFLRKMKKRSPTTI---YMINLALADLLF-VLTLPFRIYYYLNGGWWPFGDFLCRLTGLL 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 121 DVLCCTASIWNVTAIALDRYWSITRHLEYTLRTRKRVSNVMILLTWALSTVISLAPLLFGWGETYSEPSEEC------QV 194
Cdd:cd14982  80 FYINMYGSILFLTCISVDRYLAVVHPLKSRRLRRKRYAVGVCAGVWILVLVASVPLLLLRSTIAKENNSTTCfeflseWL 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 195 SREPSYTVFSTVGAFYLPLCVVLFVYWKIYRAAKfRMGSRKTNSVspvpeavevknatqhpqmvftvrhatvtfqtegdt 274
Cdd:cd14982 160 ASAAPIVLIALVVGFLIPLLIILVCYSLIIRALR-RRSKQSQKSV----------------------------------- 203
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 84370345 275 wreqKEQRAALMVGILIGVFVLCWFPFFVTELISPL--------CSWDVPA-IWKSIFLWLGYSNSFFNPLIY 338
Cdd:cd14982 204 ----RKRKALRMILIVLAVFLVCFLPYHVTRILYLLvrlsfiadCSARNSLyKAYRITLCLASLNSCLDPLIY 272
7tmA_Opsin_Gq_invertebrates cd15337
invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled ...
58-308 5.95e-15

invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The invertebrate Gq-coupled opsin subfamily includes the arthropod and mollusc visual opsins. Like the vertebrate visual opsins, arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. The invertebrate Gq opsins are closely related to the vertebrate melanopsins, the primary photoreceptor molecules for non-visual responses to light, and the R1-R6 photoreceptors, which are the fly equivalent to the vertebrate rods. The Gq opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320459 [Multi-domain]  Cd Length: 292  Bit Score: 74.28  E-value: 5.95e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  58 NLLVLATILKVRTFHRVPHNLVASMAISDV-LVAVLVMPLSLVHELSgRRWQLGRRLCQLWIACDVLCCTASIWNVTAIA 136
Cdd:cd15337  18 NLLVIYLFSKTKSLRTPSNMFIINLAISDFgFSAVNGFPLKTISSFN-KKWIWGKVACELYGFAGGIFGFMSITTLAAIS 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 137 LDRYWSITRHLEYTLRTRKRVSNVMILLTWALSTVISLAPlLFGWGETYSEPSE-ECQ---VSREP---SYTVFSTVGAF 209
Cdd:cd15337  97 IDRYLVIAKPLEAMKKMTFKRAFIMIIIIWLWSLLWSIPP-FFGWGRYVPEGFQtSCTfdyLSRDLnnrLFILGLFIFGF 175
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 210 YLPLCVVLFVYWKIYRAAKFRmgsrktnsvspvpEAVEVKNATQHPQMvftvrhatvtfQTEGDTWREQKEQRAALMVGI 289
Cdd:cd15337 176 LCPLLIIIFCYVNIIRAVRNH-------------EKEMTQTAKSGMGK-----------DTEKNDARKKAEIRIAKVAII 231
                       250
                ....*....|....*....
gi 84370345 290 LIGVFVLCWFPFFVTELIS 308
Cdd:cd15337 232 LISLFLLSWTPYAVVALLG 250
7tmA_Mel1C cd15401
melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G ...
58-349 9.94e-15

melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320523 [Multi-domain]  Cd Length: 279  Bit Score: 73.41  E-value: 9.94e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  58 NLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSGRrWQLGRRLCQLWIACDVLCCTASIWNVTAIAL 137
Cdd:cd15401  18 NLLVILSVLRNKKLRNAGNIFVVSLSVADLVVAVYPYPLILLAIFHNG-WTLGNIHCQISGFLMGLSVIGSVFNITAIAI 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 138 DRYWSITRHLEYTLRTRKRVSNVMILLTWALsTVISLAPLLFGWGETYSEPSEECQVSR--EPSYTVFSTVGAFYLPLCV 215
Cdd:cd15401  97 NRYCYICHSLRYDKLYNMKKTCCYVCLTWVL-TLAAIVPNFFVGSLQYDPRIYSCTFAQtvSSSYTITVVVVHFIVPLSI 175
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 216 VLFVYWKIYraakfrmgsrktnsvspvpeavevknatqhpQMVFTVRHATvtfQTEGDTWREQKEQRAALMVGILIGVFV 295
Cdd:cd15401 176 VTFCYLRIW-------------------------------VLVIQVKHRV---RQDSKQKLKANDIRNFLTMFVVFVLFA 221
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 84370345 296 LCWFPF-FVTELISPLCSWDVPAIWKSIFL---WLGYSNSFFNPLIYTAFNRSYSSAF 349
Cdd:cd15401 222 VCWGPLnFIGLAVAINPLKVAPKIPEWLFVlsyFMAYFNSCLNAVIYGVLNQNFRKEY 279
7tmA_QRFPR cd15205
pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane ...
41-349 1.10e-14

pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that belongs to a family of neuropeptides containing an Arg-Phe-NH2 (RFamide) motif at its C-terminus. 26Rfa/QRFP exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103.


Pssm-ID: 320333 [Multi-domain]  Cd Length: 298  Bit Score: 73.66  E-value: 1.10e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  41 VLVLTLLGflaaatftwNLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSgRRWQLGRRLCQLWIAC 120
Cdd:cd15205  10 IFVLALFG---------NSLVIYVVTRKRAMRTATNIFICSLALSDLLITFFCIPFTLLQNIS-SNWLGGAFMCKMVPFV 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 121 DVLCCTASIWNVTAIALDRYWSITRHLEYTLRTRKRVSNVMILLTWALStVISLAPLLFGWG-ETYSEPSEE-----CQ- 193
Cdd:cd15205  80 QSTAVVTSILTMTCIAVERHQGIVHPLKMKWQYTNRRAFTMLGLVWIVS-VIVGSPMLFVQQlEVKYDFLYEkrhvcCLe 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 194 ----VSREPSYTVFSTVGAFYLPLCVVLFVYWKIyraaKFRMGSRKtnsvsPVPEAvEVKNATQHPQMVFTVRhatvtfq 269
Cdd:cd15205 159 rwysPTQQKIYTTFILVILFLLPLTTMLFLYSRI----GYELWIKK-----RVGDA-SVLQTIHGIEMSKISR------- 221
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 270 tegdtwreqKEQRAALMVGILIGVFVLCWFPFFVTELISPLCSWDVPAIWKSIFL------WLGYSNSFFNPLIYTAFNR 343
Cdd:cd15205 222 ---------KKKRAVKMMVTVVLLFAVCWAPFHVVHMMIEYSNLENKYDGVTIKLifaivqLIGFSNSFNNPIVYAFMNE 292

                ....*.
gi 84370345 344 SYSSAF 349
Cdd:cd15205 293 NFKKNF 298
7tmA_SSTR2 cd15971
somatostatin receptor type 2, member of the class A family of seven-transmembrane G ...
43-349 2.11e-14

somatostatin receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin, a polypeptide hormone that regulates a wide variety of physiological such as neurotransmission, endocrine secretion, cell proliferation, and smooth muscle contractility. SSTRs are composed of five distinct subtypes (SSTR1-5) which are encoded by separate genes on different chromosomes. SSTR2 plays critical roles in growth hormone secretion, glucagon secretion, and immune responses. SSTR2 is expressed in the normal human pituitary and in nearly all pituitary growth hormone adenomas.


Pssm-ID: 320637 [Multi-domain]  Cd Length: 279  Bit Score: 72.57  E-value: 2.11e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  43 VLTLLGFLAAAT-FTWNLLVLATILKVRTFHRVPHNLVASMAISDVL----VAVLVMPLSLVHelsgrrWQLGRRLCQLW 117
Cdd:cd15971   2 FLTFIYFVVCIIgLCGNTLVIYVILRYAKMKTVTNIYILNLAIADELfmlgLPFLAIQVALVH------WPFGKAICRVV 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 118 IACDVLCCTASIWNVTAIALDRYWSITRHLEYTLRTRKRVSNVMILLTWALSTVISLAPLLFGWGETYSEPSEECQVSRE 197
Cdd:cd15971  76 MTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRKPRTAKMINMAVWGVSLLVILPIMIYAGVQTKHGRSSCTIIWPG 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 198 PS------YTVFSTVGAFYLPLCVVLFVYWKI---YRAAKFRMGSRKtnsvspvpeavevknatqhpqmvftvrhatvtf 268
Cdd:cd15971 156 ESsawytgFIIYTFILGFFVPLTIICLCYLFIiikVKSSGIRVGSSK--------------------------------- 202
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 269 qtegdtwREQKEQRAALMVGILIGVFVLCWFPFFVTELISPLCSWDVPAIWKSIFLW---LGYSNSFFNPLIYTAFNRSY 345
Cdd:cd15971 203 -------RKKSEKKVTRMVSIVVAVFVFCWLPFYIFNVSSVSVSISPTPGLKGMFDFvvvLSYANSCANPILYAFLSDNF 275

                ....
gi 84370345 346 SSAF 349
Cdd:cd15971 276 KKSF 279
7tmA_GPR61_GPR62-like cd15220
G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G ...
39-343 2.23e-14

G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the orphan receptors GPR61 and GPR62, which are both constitutively active and predominantly expressed in the brain. While GPR61 couples to G(s) subtype of G proteins, the signaling pathway and function of GPR 62 are unknown. GPR61-deficient mice displayed significant hyperphagia and heavier body weight compared to wild-type mice, suggesting that GPR61 is involved in the regulation of food intake and body weight. GPR61 transcript expression was found in the caudate, putamen, and thalamus of human brain, whereas GPR62 transcript expression was found in the basal forebrain, frontal cortex, caudate, putamen, thalamus, and hippocampus. Both receptors share the highest sequence homology with each other and comprise a conserved subgroup within the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. Members of this subgroup contain [A/E]RY motif, a variant of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the class A GPCRs and important for efficient G protein-coupled signal transduction.


Pssm-ID: 410633 [Multi-domain]  Cd Length: 264  Bit Score: 72.10  E-value: 2.23e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  39 FRVLVLTLLGFLAaatftwNLLVLATILKVRTFHRVPhnLVASMAISDVLVAVLVMPLSLvheLSGRRWQLGRRL----C 114
Cdd:cd15220   4 FCMVLLDLTALVG------NTAVMVVIAKTPHLRKFA--FVCHLCVVDLLAALLLMPLGI---LSSSPFFLGVVFgeaeC 72
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 115 QLWIACDVLCCTASIWNVTAIALDRYWSITRHLEYTLRTRKRVSNVMILLTWALSTVISLAPLL--FGWGETYSEPSEEC 192
Cdd:cd15220  73 RVYIFLSVCLVSASILTISAISVERYYYIVHPMRYEVKMTIGLVAAVLVGVWVKALLLGLLPVLgwPSYGGPAPIAARHC 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 193 QVSREPS-----YTVFSTVGAFYLPLCVVLFVYWKIYRAakfrMGSRKtnsvspvpeavevknatqhpqmvftvrhatvt 267
Cdd:cd15220 153 SLHWSHSghrgvFVVLFALVCFLLPLLLILVVYCGVFKV----FGGGK-------------------------------- 196
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 84370345 268 fqtegdtwreqkeqrAALMVGILIGVFVLCWFPFFVTELISPLCSWDV-PAIWKSIFLWLGYSNSFFNPLIYTAFNR 343
Cdd:cd15220 197 ---------------AALTLAAIVGQFLCCWLPYFAFHLYSALAASPVsGGEAEEVVTWLAYSCFAVNPFFYGLLNR 258
7tmA_TACR cd15390
neurokinin receptors (or tachykinin receptors), member of the class A family of ...
38-349 2.28e-14

neurokinin receptors (or tachykinin receptors), member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320512 [Multi-domain]  Cd Length: 289  Bit Score: 72.71  E-value: 2.28e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  38 AFRVLVLTLLGFLAAATftwNLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSGRrWQLGRRLCQLW 117
Cdd:cd15390   1 VLWSIVFVVMVLVAIGG---NLIVIWIVLAHKRMRTVTNYFLVNLAVADLLISAFNTVFNFTYLLYND-WPFGLFYCKFS 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 118 IACDVLCCTASIWNVTAIALDRYWSITRHLEYtlRTRKRVSNVMILLTWALSTVISLAPLLFGWGETYSEPSEE----CQ 193
Cdd:cd15390  77 NFVAITTVAASVFTLMAISIDRYIAIVHPLRP--RLSRRTTKIAIAVIWLASFLLALPQLLYSTTETYYYYTGSertvCF 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 194 VSREPS--------YTVFSTVGAFYLPLCVVLFVYwkiyraakFRMGSRKTNSvspvpEAVEVKNATQHPQMvftvrhat 265
Cdd:cd15390 155 IAWPDGpnslqdfvYNIVLFVVTYFLPLIIMAVAY--------TRVGVELWGS-----KTIGENTPRQLESV-------- 213
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 266 vtfqtegdtwreQKEQRAALMVGILIGVFVLCWFP----FFVTELISPLCSWD-VPAIWKSIFlWLGYSNSFFNPLIYTA 340
Cdd:cd15390 214 ------------RAKRKVVKMMIVVVVIFAICWLPyhlyFILTYLYPDINSWKyIQQIYLAIY-WLAMSNSMYNPIIYCW 280

                ....*....
gi 84370345 341 FNRSYSSAF 349
Cdd:cd15390 281 MNKRFRYGF 289
7tmA_Mel1 cd15209
melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
58-345 3.05e-14

melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320337 [Multi-domain]  Cd Length: 279  Bit Score: 72.12  E-value: 3.05e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  58 NLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLvHELSGRRWQLGRRLCQLWIACDVLCCTASIWNVTAIAL 137
Cdd:cd15209  18 NLLVILSVLRNKKLRNAGNIFVVSLSVADLVVAIYPYPLIL-HAIFHNGWTLGQLHCQASGFIMGLSVIGSIFNITAIAI 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 138 DRYWSITRHLEYTLRTRKRVSNVMILLTWALsTVISLAPLLFGWGETYSEPSEECQVSR--EPSYTVFSTVGAFYLPLCV 215
Cdd:cd15209  97 NRYCYICHSLQYDRLYSLRNTCCYLCLTWLL-TVLAVLPNFFIGSLQYDPRIYSCTFAQtvSTVYTITVVVIHFLLPLLI 175
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 216 VLFVY---WKIYRAAKFRMGSRKTNSVSPvpeavevknatqhpqmvftvrhatvtfqtegdtwreqKEQRAALMVGILIG 292
Cdd:cd15209 176 VSFCYlriWVLVLQVRQRVKPDQRPKLKP-------------------------------------ADVRNFLTMFVVFV 218
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 84370345 293 VFVLCWFPF-FVTELISPLCSWDVPAIWKSIFL---WLGYSNSFFNPLIYTAFNRSY 345
Cdd:cd15209 219 LFAVCWAPLnFIGLAVAINPKEMAPKIPEWLFVasyFMAYFNSCLNAIIYGLLNQNF 275
7tmA_GHSR-like cd15928
growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the ...
62-348 7.03e-14

growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes growth hormone secretagogue receptor (GHSR or ghrelin receptor), motilin receptor (also called GPR38), and related proteins. Both GHSR and GPR38 bind peptide hormones. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin is also called the hunger hormone and is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. Motilin, the ligand for GPR38, is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. It is involved in the regulation of digestive tract motility.


Pssm-ID: 320594 [Multi-domain]  Cd Length: 288  Bit Score: 70.98  E-value: 7.03e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  62 LATILKV--RTFHRVPHNL-VASMAISDVLVaVLVMPLSLVHELSGRRWQLGRRLCQLWIACDVLCCTASIWNVTAIALD 138
Cdd:cd15928  19 LLTVLVIgrSRDMRTTTNLyLSSLAVSDLLI-FLVLPLDLYRLWRYRPWRFGDLLCRLMYFFSETCTYASILHITALSVE 97
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 139 RYWSITRHLEYTLRTRKRVSNVMILLTWALStVISLAPLLFGWGETYSEPSE-----ECQVSREPS--YTVFSTVGA--F 209
Cdd:cd15928  98 RYLAICHPLRAKVLVTRGRVKLLIAVIWAVA-IVSAGPALVLVGVEHIQGQQtprgfECTVVNVSSglLSVMLWVSTsfF 176
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 210 YLPLCVVLFVYWKIYRAAKFRMGSRKTNSVSPvpeavevknatqhpqmvftvrhatvtfqtegdtwREQKEQRAALMVGI 289
Cdd:cd15928 177 FVPMVCLSLLYGLIGRALWDRRQRSRTAGASR----------------------------------RDNNHRQTVRMLAV 222
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 84370345 290 LIGVFVLCWFPFFVTELI------SPLCSWDVPAIWKSIFLWLGYSNSFFNPLIYTAFNRSYSSA 348
Cdd:cd15928 223 IVLAFVLCWLPFHVGRVIfnhsraSTKHLHYVSQYFNLVSFVLFYLSAAINPILYNLMSKRYRYA 287
7tmA_Mel1A cd15402
melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G ...
45-224 7.09e-14

melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320524 [Multi-domain]  Cd Length: 279  Bit Score: 71.09  E-value: 7.09e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  45 TLLGFLAAATFTWNLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVhELSGRRWQLGRRLCQLWIACDVLC 124
Cdd:cd15402   5 CILIFTIVVDILGNLLVILSVYRNKKLRNAGNIFVVSLAVADLVVAIYPYPLVLT-SIFHNGWNLGYLHCQISGFLMGLS 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 125 CTASIWNVTAIALDRYWSITRHLEYTLRTRKRVSNVMILLTWALsTVISLAPLLFGWGETYSEPSEECQVSREPS--YTV 202
Cdd:cd15402  84 VIGSIFNITGIAINRYCYICHSLKYDKLYSDKNSLCYVLLIWVL-TVAAIVPNLFVGSLQYDPRIYSCTFAQSVSsaYTI 162
                       170       180
                ....*....|....*....|..
gi 84370345 203 FSTVGAFYLPLCVVLFVYWKIY 224
Cdd:cd15402 163 AVVFFHFILPIIIVTFCYLRIW 184
7tmA_GPR135 cd15212
G protein-coupled receptor 135, member of the class A family of seven-transmembrane G ...
38-342 7.78e-14

G protein-coupled receptor 135, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR135, also known as the somatostatin- and angiotensin-like peptide receptor (SALPR), is found in various tissues including eye, brain, cervix, stomach, and testis. Pharmacological studies have shown that relaxin-3 (R3) is a high-affinity endogenous ligand for GPR135. R3 has recently been identified as a new member of the insulin/relaxin family of peptide hormones and is exclusively expressed in the brain neurons. In addition to GPR135, R3 also acts as an agonist for GPR142, a pseudogene in the rat, and can activate LGR7 (leucine repeat-containing G-protein receptor-7), which is the main receptor for relaxin-1 (R1) and relaxin-2 (R2). While R1 and R2 are hormones primarily associated with reproduction and pregnancy, R3 is involved in neuroendocrine and sensory processing. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320340 [Multi-domain]  Cd Length: 285  Bit Score: 70.95  E-value: 7.78e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  38 AFRVLVLTLLGFLAAATftwNLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSGRRWQLGRRLCqlw 117
Cdd:cd15212   1 AAQALVLLAIFLLSSLG---NCAVIGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPFAFLTLFSRPGWLFGDRLC--- 74
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 118 IACDVLCC---TASIWNVTAIALDRYWSITRHLEYTLRTRKRVSnvMILLTWALSTVISLAPLLFGWGETYSEPS--EEC 192
Cdd:cd15212  75 LANGFFNAcfgIVSTLTMTLISFDRYYAIVRQPQGKIGRRRALQ--LLAAAWLTALGFSLPWYLLASAPEYYEKLgfYHC 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 193 QV------SR-EPSYTVFSTVGAFYLPLCVVLFVYWKIYRAAKfrmgsrktNSVSpvpeavevknatqhpqmvfTVRHAT 265
Cdd:cd15212 153 LYvlhsgpSRlGAAYSSVLIVLCYLLPFALMCFCHYNICKTVR--------LSES-------------------RVRPVT 205
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 84370345 266 vtfqTEGDTWREQKEQRAALMVGILIGVFVLCWFPFFVTELISPLCSWDVPAIWKSIFLWLGYSNSFFNPLIYTAFN 342
Cdd:cd15212 206 ----TYAHLLRFYSEMRTATTVLIMIVFIICCWGPYCLLGLVAAAGGYQFPPLMDTVAIWMAWANGAINPLIYAIRN 278
7tmA_SREB3_GPR173 cd15217
super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of ...
44-343 8.16e-14

super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320345 [Multi-domain]  Cd Length: 329  Bit Score: 71.52  E-value: 8.16e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  44 LTLLGFLAAATFTWNLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSGRRWQLGRRLCQLWIACDVL 123
Cdd:cd15217   4 LVLLGLIICVSLAGNLIVSLLVLKDRALHKAPYYFLLDLCLADTIRSAVCFPFVLVSIRNGSAWTYSVLSCKIVAFMAVL 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 124 CCTASIWNVTAIALDRYWSITRHLEYTLRTRKRVSNVMILLTWALSTVISLAPlLFGWGeTYSEPSEECQVSREPSYTVF 203
Cdd:cd15217  84 FCFHAAFMLFCISVTRYMAIAHHRFYSKRMTFWTCIAVICMVWTLSVAMAFPP-VFDVG-TYKFIREEDQCIFEHRYFKA 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 204 STVGAFYLPLCVVLFVYWKIY-RAAKFRMGSRKTNSVSPVPEAVEvkNATQH---------------------PQMVFTV 261
Cdd:cd15217 162 NDTLGFMLMLAVLIVATHIVYgKLLLFEYRHRKMKPVQMVPAISQ--NWTFHgpgatgqaaanwiagfgrgpmPPTLLGI 239
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 262 RHATVTFQTEGDTWREQK-EQRAALMVGILIGVFVLCWFPFFVTelisplCSWDV-------PAIWKSIFLWLGYSNSFF 333
Cdd:cd15217 240 RQNAHTANRRLLGMEEFKaEKRLGRMFYVITLSFLVLWSPYIVA------CYWRVfvkacsiPHRYLSTAVWMSFAQAGV 313
                       330
                ....*....|
gi 84370345 334 NPLIYTAFNR 343
Cdd:cd15217 314 NPIVCFLLNK 323
7tmA_GPR26_GPR78-like cd15219
G protein-coupled receptors 26 and 78, member of the class A family of seven-transmembrane G ...
58-345 1.14e-13

G protein-coupled receptors 26 and 78, member of the class A family of seven-transmembrane G protein-coupled receptors; Orphan G-protein coupled receptor 26 (GPR26) and GPR78 are constitutively active and coupled to increased cAMP formation. They are closely related based on sequence homology and comprise a conserved subgroup within the class A G-protein coupled receptor (GPCR) superfamily. Both receptors are widely expressed in selected tissues of the brain but their endogenous ligands are unknown. GPR26 knockout mice showed increased levels of anxiety- and depression-like behaviors, whereas GPR78 has been implicated in susceptibility to bipolar affective disorder and schizophrenia. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320347 [Multi-domain]  Cd Length: 264  Bit Score: 70.18  E-value: 1.14e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  58 NLLVLATIL---KVRTfhRVPHNLVASMAISDVLVAVLVMPLSLVHELSGRRwQLGRRLCQLWIACDVLCCTASIWNVTA 134
Cdd:cd15219  17 NLLVLLCFLysaELRK--QVPGIFLLNLSFCNLLLTVLNMPFTLLGVVRNRQ-PFGDGFCQAVGFLETFLTSNAMLSMAA 93
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 135 IALDRYWSITRHLEYTLRTRKRVSNVMILLTWALSTVISLAPLLFGWGEtYSEPSEECQVS--REPS------YTVFSTV 206
Cdd:cd15219  94 LSIDRWIAVVFPLSYTSKMRYRDAALMVGYSWLHSLTFSLVALFLSWLG-YSSLYASCTLHlpREEErrrfavFTAFFHA 172
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 207 GAFYLPLCVVLFVYWKiyraakfrmgsrktnsvspvpeavevknatqhpqmVFTVRhatvtfqtegdtwreqKEQRAALM 286
Cdd:cd15219 173 FTFLLSLLVLCVTYLK-----------------------------------VLKVR----------------RRQRATKK 201
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 84370345 287 VGILIGVFVLCWFPFFVTELISPLCSWDVPAIWKSIFLWLGYSNSFFNPLIYTAFNRSY 345
Cdd:cd15219 202 ISIFIGTFVLCFAPYVITRLVELLPFVTINRYWGIVSKCLTYSKAASDPFVYSLLRQQY 260
7tm_GPCRs cd14964
seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...
58-342 1.81e-13

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410628 [Multi-domain]  Cd Length: 267  Bit Score: 69.76  E-value: 1.81e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  58 NLLVLATILKVRTFHRVPHNLVASMAISDvLVAVLVMPLSLVHELSGRRWQLGRRLCQLWIACDVLCCTASIWNVTAIAL 137
Cdd:cd14964  16 NLLVLLSLVRLRKRPRSTRLLLASLAACD-LLASLVVLVLFFLLGLTEASSRPQALCYLIYLLWYGANLASIWTTLVLTY 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 138 DRYWSITRHLEYTLRTRKRVSNVMILLTWALSTVISLAPLLFGWGE-TYSEPSEECQV-SREPSYTVFSTVGAFYLPLCV 215
Cdd:cd14964  95 HRYFALCGPLKYTRLSSPGKTRVIILGCWGVSLLLSIPPLVGKGAIpRYNTLTGSCYLiCTTIYLTWGFLLVSFLLPLVA 174
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 216 VLFVYWKIYRaAKFRMGSRKTNSVSPVPEavevknatqhpqmvftvrhatvtfqtegdtwreqKEQRAALMVGILIGVFV 295
Cdd:cd14964 175 FLVIFSRIVL-RLRRRVRAIRSAASLNTD----------------------------------KNLKATKSLLILVITFL 219
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 84370345 296 LCWFPFFVTELISPLCSWDVPAIWKSIF-LWLGYSNSFFNPLIYTAFN 342
Cdd:cd14964 220 LCWLPFSIVFILHALVAAGQGLNLLSILaNLLAVLASTLNPFIYCLGN 267
7tmA_GPR83 cd15389
G protein-coupled receptor 83, member of the class A family of seven-transmembrane G ...
41-348 1.86e-13

G protein-coupled receptor 83, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR83, also known as GPR72, is widely expressed in the brain, including hypothalamic nuclei which is involved in regulating energy balance and food intake. The hypothalamic expression of GPR83 is tightly regulated in response to nutrient availability and is decreased in obese mice. A recent study suggests that GPR83 has a critical role in the regulation of systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms. GPR83 shares a significant amino acid sequence identity with the tachykinin receptors, however its endogenous ligand is unknown.


Pssm-ID: 320511 [Multi-domain]  Cd Length: 285  Bit Score: 69.67  E-value: 1.86e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  41 VLVLTLLGFLAAATFTWNLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSGRrWQLGRRLCQLWIAC 120
Cdd:cd15389   1 ALLIVAYSIIIVISLFGNSLVCHVIFKNKRMHTATNLFIVNLAVSDILITLLNTPFTLVRFVNST-WVFGKIMCHLSRFA 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 121 DVLCCTASIWNVTAIALDRYWSITRHLEYtlRTRKRVSNVMILLTWALSTVISLAPLLFG--WGETYSEPSEE--CQVS- 195
Cdd:cd15389  80 QYCSVYVSTLTLTAIALDRHRVILHPLKP--RITPCQGVVVIAIIWIMASCLSLPHAIYQklVEFEYSNERTRsrCLPSf 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 196 REPS-----YTVFSTVGAFY-LPLCVVLFVYWKIYRaakfRMGSRKTnsvspvpeaveVKNATQHPQMvftvrhatvtfq 269
Cdd:cd15389 158 PEPSdlfwkYLDLATFILQYvLPLLIIGVAYTRVAK----KLWLRNA-----------IGDVTTEQYV------------ 210
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 84370345 270 tegdtWREQKEQRAALMVGILIGVFVLCWFPFFVTELISPLCSWDVPAIWKSIFLWLGYSNSFFNPLIYTAFNRSYSSA 348
Cdd:cd15389 211 -----AQRRKKKKTIKMLMLVVLLFAICWLPLNCYHVLLSSHPIRSNSALFFAFHWLAMSSTCYNPFIYCWLNDSFRSE 284
7tmA_GnRHR_invertebrate cd15384
invertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
41-341 2.25e-13

invertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320506 [Multi-domain]  Cd Length: 293  Bit Score: 69.77  E-value: 2.25e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  41 VLVLTLLGFLAAATFTWNLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPlSLVHELSGRRWQLGRRLCQLWIAC 120
Cdd:cd15384   1 LLKIVVLAVMFVISFIGNLLTIIQIYRLRRSRRTIYSLLLHLAIADLLVTFFCIP-SEAIWAYTVAWLAGNTMCKLVKYL 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 121 DVLCCTASIWNVTAIALDRYWSITRHLEyTLRTRKRVSNvMILLTWALSTVISLA------------PLLFGWGETYSEP 188
Cdd:cd15384  80 QVFGLYLSTYITVLISLDRCVAILYPMK-RNQAPERVRR-MVTVAWILSPIFSIPqavifhvergpfVEDFHQCVTYGFY 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 189 SEECQvsrEPSYTVFSTVGAFYLPLCVVLFVYWKIYRAAKfrmgsrktnsvspvpeavevknatQHPQMVFTVRHATVTF 268
Cdd:cd15384 158 TAEWQ---EQLYNMLSLVFMFPIPLVIMVTCYVLIFITLS------------------------KSSRDFQGLEIYTRNR 210
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 84370345 269 QTEGDTWREQKEQRAALMVGILIGVFVLCWFPFFVTELISPLCSWD-VPAIWKSIFLWLGYSNSFFNPLIYTAF 341
Cdd:cd15384 211 GPNRQRLFHKAKVKSLRMSAVIVTAFILCWTPYYVIMIWFLFFNPYpLNDILFDVIFFFGMSNSCVNPLIYGAF 284
7tmA_SREB2_GPR85 cd15218
super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of ...
42-349 3.78e-13

super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320346 [Multi-domain]  Cd Length: 330  Bit Score: 69.29  E-value: 3.78e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  42 LVLTLLGFLAAATFTWNLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSGRRWQLGRRLCQLWIACD 121
Cdd:cd15218   2 LKLTSLGFIIGVSVVGNLLISILLVKDKTLHRAPYYFLLDLCCSDILRSAICFPFVFTSVKNGSTWTYGTLTCKVIAFLG 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 122 VLCCTASIWNVTAIALDRYWSITRHLEYTLRTRKRVSNVMILLTWALSTVISLAPLLFGWGETYSEPSEECQVSREpSYT 201
Cdd:cd15218  82 VLSCFHTAFMLFCISVTRYLAIAHHRFYTKRLTFWTCLAVICMVWTLSVAMAFPPVLDVGTYSFIREEDQCTFQHR-SFR 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 202 VFSTVGaFYLPLCVVLFVYWKIYRAAKFRMGSRKtnSVSPVPEAVEV-KNATQH----------------------PQMV 258
Cdd:cd15218 161 ANDSLG-FMLLLALILLATQLVYLKLIFFVHDRR--KMKPVQFVAAVsQNWTFHgpgasgqaaanwlagfgrgptpPTLL 237
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 259 FTVRHATVTFQTEGDTWREQK-EQRAALMVGILIGVFVLCWFPFFVTelisplCSWD-------VPAIWKSIFLWLGYSN 330
Cdd:cd15218 238 GIRQNANTTGRRRLLVLDEFKmEKRISRMFYIMTFLFLTLWGPYLVA------CYWRvfargpvVPGGFLTAAVWMSFAQ 311
                       330
                ....*....|....*....
gi 84370345 331 SFFNPLIYTAFNRSYSSAF 349
Cdd:cd15218 312 AGINPFVCIFSNRELRRCF 330
7tmA_SSTR cd15093
somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
58-349 4.16e-13

somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. They share common signaling cascades such as inhibition of adenylyl cyclase, activation of phosphotyrosine phosphatase activity, and G-protein-dependent regulation of MAPKs.


Pssm-ID: 320221 [Multi-domain]  Cd Length: 280  Bit Score: 68.64  E-value: 4.16e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  58 NLLVLATILKVRTFHRVPHNLVASMAISDVLVaVLVMPLsLVHELSGRRWQLGRRLCQLWIACDVLCCTASIWNVTAIAL 137
Cdd:cd15093  18 NSLVIYVVLRYAKMKTVTNIYILNLAIADELF-MLGLPF-LAASNALRHWPFGSVLCRLVLSVDGINMFTSIFCLTVMSV 95
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 138 DRYWSITRHLEYTLRTRKRVSNVMILLTWALSTVISLAPLLFGWGETYSEPSEECQVS-REPS------YTVFSTVGAFY 210
Cdd:cd15093  96 DRYLAVVHPIKSARWRRPRVAKVVNLAVWVASLLVILPVVVFAGTRENQDGSSACNMQwPEPAaawsagFIIYTFVLGFL 175
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 211 LPLCVVLFVYWKIYRaaKFRMGSRKTnsvspvpeavevknatqhpqmvftvrhatvtfqteGDTWREQKEQRAALMVGIL 290
Cdd:cd15093 176 LPLLIICLCYLLIVI--KVKSAGLRA-----------------------------------GWQQRKRSERKVTRMVVMV 218
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 84370345 291 IGVFVLCWFPFFVTELISPLCSWDVPAIWKSIF---LWLGYSNSFFNPLIYTAFNRSYSSAF 349
Cdd:cd15093 219 VVVFVICWLPFYVLQLVNVFVQLPETPALVGVYhfvVILSYANSCANPILYGFLSDNFKKSF 280
7tmA_GnRHR-like cd15195
gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A ...
39-349 4.55e-13

gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Gonadotropin-releasing hormone (GnRH) and adipokinetic hormone (AKH) receptors share strong sequence homology to each other, suggesting that they have a common evolutionary origin. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flying, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320323 [Multi-domain]  Cd Length: 293  Bit Score: 68.96  E-value: 4.55e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  39 FRVLVLTLLGFLAAATftwNLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSgRRWQLGRRLCQLWI 118
Cdd:cd15195   2 VRVLVTWVLFVISAAG---NLTVLIQLFRRRRAKSHIQILIMHLALADLMVTFFNMPMDAVWNYT-VEWLAGDLMCRVMM 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 119 ACDVLCCTASIWNVTAIALDRYWSITRHLEYTlRTRKRVSnVMILLTWALSTVISLAPL-LFGWGETYSEPSEECQV--- 194
Cdd:cd15195  78 FLKQFGMYLSSFMLVVIALDRVFAILSPLSAN-QARKRVK-IMLTVAWVLSALCSIPQSfIFSVLRKMPEQPGFHQCvdf 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 195 ------SREPSYTVFSTVGAFYLPLCVVLFVYWKIyraakfrmgsrktnsvspVPEAVEVKNATQHPQMVFTVRHATVTF 268
Cdd:cd15195 156 gsaptkKQERLYYFFTMILSFVIPLIITVTCYLLI------------------LFEISKMAKRARDTPISNRRRSRTNSL 217
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 269 QtegdtwREQKeqRAALMVGILIGVFVLCWFPFFVTEL---ISPLCSWDVPAIWKSIFLWLGYSNSFFNPLIYTAFNRSY 345
Cdd:cd15195 218 E------RARM--RTLRMTALIVLTFIVCWGPYYVLGLwywFDKESIKNLPPALSHIMFLLGYLNPCLHPIIYGVFMKEI 289

                ....
gi 84370345 346 SSAF 349
Cdd:cd15195 290 RNWI 293
7tmA_AstA_R_insect cd15096
allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G ...
41-349 5.10e-13

allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled AstA receptor binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320224 [Multi-domain]  Cd Length: 284  Bit Score: 68.48  E-value: 5.10e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  41 VLVLTLLGFLAAATFTWNLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSGRrWQLGRRLCQLWIAC 120
Cdd:cd15096   1 IVVPVIFGLIFIVGLIGNSLVILVVLSNQQMRSTTNILILNLAVADLLFVVFCVPFTATDYVLPT-WPFGDVWCKIVQYL 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 121 DVLCCTASIWNVTAIALDRYWSITRHLEY-TLRTrKRVSNVMILLTWALsTVISLAPLLFGWGETY----SEPSEECQVS 195
Cdd:cd15096  80 VYVTAYASVYTLVLMSLDRYLAVVHPITSmSIRT-ERNTLIAIVGIWIV-ILVANIPVLFLHGVVSygfsSEAYSYCTFL 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 196 REPSYTVFSTVGAFY-----LPLCVVLFVYWKIYraakFRMGSRKTNSVSPVPEAVEVKNatqhpqmvftvrhatvtfqt 270
Cdd:cd15096 158 TEVGTAAQTFFTSFFlfsylIPLTLICVLYMLML----RRLRRQKSPGGRRSAESQRGKR-------------------- 213
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 271 egdtwreqkeqRAALMVGILIGVFVLCWFPFFVTELISPLcSWDVPAIWKSIFL----WLGYSNSFFNPLIYTAFNRSYS 346
Cdd:cd15096 214 -----------RVTRLVVVVVVVFAICWLPIHIILLLKYY-GVLPETVLYVVIQilsnCLAYGNSCVNPILYAFLSQNFR 281

                ...
gi 84370345 347 SAF 349
Cdd:cd15096 282 KAF 284
7tmA_GPR39 cd15135
G protein-coupled receptor 39, member of the class A family of seven-transmembrane G ...
41-349 9.12e-13

G protein-coupled receptor 39, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR39 is an orphan G protein-coupled receptor that belongs to the growth hormone secretagogue and neurotensin receptor subfamily. GPR39 is expressed in peripheral tissues such as pancreas, gut, gastrointestinal tract, liver, kidney as well as certain regions of the brain. The divalent metal ion Zn(2+) has been shown to be a ligand capable of activating GPR39. Thus, it has been suggested that GPR39 function as a G(q)-coupled Zn(2+)-sensing receptor which involved in the regulation of endocrine pancreatic function, body weight, gastrointestinal mobility, and cell death.


Pssm-ID: 320263 [Multi-domain]  Cd Length: 320  Bit Score: 68.28  E-value: 9.12e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  41 VLVLTLLGFLAAATFTWNLLVLATILKVRTFHRVphnlvaSMAISDVLVAVLVMPLSLVHEL-SGRRWQLGRRLCQLWIA 119
Cdd:cd15135  10 ILVAGILGNSATIKVTQVLQKKGYLQKSVTDHMV------SLACSDLLVLLLGMPVELYSAIwDPFATPSGNIACKIYNF 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 120 CDVLCCTASIWNVTAIALDRYWSITRHLEYtLRTRKRVSNVMILLTWALSTVISLaPLLFGWG-ETYSEPSEECQVSREP 198
Cdd:cd15135  84 LFEACSYATILNVATLSFERYIAICHPFKY-KALSGSRVRLLICFVWLTSALVAL-PLLFAMGtEDPLEAFPSYRGTRHH 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 199 ----------------SYTVF--STVGAFYLPLCVVLFVYWKIYRAAKFRMGSRKtnsvspvpEAVEVKNATQHPQMVft 260
Cdd:cd15135 162 cqdqksnltictslssKWTVFqaSIFSAFVLYLLVLASVAFMCRRMMRALMGSKK--------GAVAVKGPGGSVQLL-- 231
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 261 VRHATvtfqTEGDTWREQkeqrAALMVGILIGVFVLCWFPFFVTELIS---PLCSWDVPAIWKSIFLwLGYSNSFF---- 333
Cdd:cd15135 232 RKHES----AEGKTARKQ----TILFLGLIVGTLAVCWMPNQIRRIMAaakPKDDWTRSYFRAYIIL-LPIADTFFylss 302
                       330
                ....*....|....*...
gi 84370345 334 --NPLIYTAFNRSYSSAF 349
Cdd:cd15135 303 vlNPLLYNLSSQQFRSVF 320
7tmA_GHSR cd15131
growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G ...
49-348 9.17e-13

growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Growth hormone secretagogue receptor, GHSR, is also known as GH-releasing peptide receptor (GHRP) or Ghrelin receptor. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin, also called hunger hormone, is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. It also plays a role in the cardiovascular, immune, and reproductive systems. GHSR couples to G-alpha-11 proteins. Both ghrelin and GHSR are expressed in a wide range of cancer tissues. Recent studies suggested that ghrelin may play a role in processes associated with cancer progression, including cell proliferation, metastasis, apoptosis, and angiogenesis.


Pssm-ID: 320259 [Multi-domain]  Cd Length: 291  Bit Score: 67.99  E-value: 9.17e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  49 FLAAATFTWNLLVLATILKVRTFHRVPHNLVASMAISDVLVaVLVMPLSLVHELSGRRWQLGRRLCQLWIACDVLCCTAS 128
Cdd:cd15131   9 LLFVVGVTGNLMTMLVVSKYRDMRTTTNLYLSSMAFSDLLI-FLCMPLDLYRLWQYRPWNFGDLLCKLFQFVSESCTYST 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 129 IWNVTAIALDRYWSITRHLEYTLRTRKRVSNVMILLTWALStVISLAPLLFGWG---ETYSEP--SEECQVS----REPS 199
Cdd:cd15131  88 ILNITALSVERYFAICFPLRAKVVVTKRRVKLVILVLWAVS-FLSAGPIFVLVGvehENGTNPidTNECKATeyavRSGL 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 200 YTVFSTVGA--FYLPLCVVLFVYWKIYRaakfRMGSRKTNSVSPvpeavevknatqhpqmvftvrhatvtfqteGDTWRE 277
Cdd:cd15131 167 LTIMVWVSSvfFFLPVFCLTVLYSLIGR----KLWRRRRENIGP------------------------------NASHRD 212
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 84370345 278 QKEQRAALMVGILIGVFVLCWFPFFVTELISPLCSWDVPAIWKSIFLW-------LGYSNSFFNPLIYTAFNRSYSSA 348
Cdd:cd15131 213 KNNRQTVKMLAVVVFAFVLCWLPFHVGRYLFSKSFEAGSLEIALISQYcnlvsfvLFYLSAAINPILYNIMSKKYRVA 290
7tmA_tmt_opsin cd15086
teleost multiple tissue (tmt) opsin, member of the class A family of seven-transmembrane G ...
41-349 1.15e-12

teleost multiple tissue (tmt) opsin, member of the class A family of seven-transmembrane G protein-coupled receptors; Teleost multiple tissue (tmt) opsins are homologs of encephalopsin. Mouse encephalopsin (or panopsin) is highly expressed in the brain and testes, whereas the teleost homologs are localized to multiple tissues. The exact functions of the encephalopsins and tmt-opsins are unknown. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Tmt opsins belong to the class A of the G protein-coupled receptors and show strong homology to the vertebrate visual opsins.


Pssm-ID: 320214 [Multi-domain]  Cd Length: 276  Bit Score: 67.45  E-value: 1.15e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  41 VLVLTLLGFLAAATFTWNLLVLATILKVRTFhRVPHN-LVASMAISDVLVAVLVMPLSLVHELSGrRWQLGRRLCQLWIA 119
Cdd:cd15086   1 TVVAVFLGFILTFGFLNNLLVLVLFCKYKVL-RSPINlLLLNISLSDLLVCVLGTPFSFAASTQG-RWLIGEHGCRWYGF 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 120 CDVLCCTASIWNVTAIALDRYWSITRHLEYTLRTRKRVSnVMILLTWALSTVISLAPlLFGWGETYSE-PSEECQV---S 195
Cdd:cd15086  79 ANSLFGIVSLISLAVLSYERYCTLLRPTEADVSDYRKAW-LGVGGSWLYSLLWTLPP-LLGWSSYGPEgPGTTCSVqwtS 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 196 REP---SYTVFSTVGAFYLPLCVVLFVYWKIYRAAKFRMGSRKTNSvspvpeavevknatqhpqmvftvrhatvtfqteg 272
Cdd:cd15086 157 RSAnsiSYIICLFIFCLLLPFLVMVYCYGRLLYAIKQVGKINKSTA---------------------------------- 202
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 273 dtwrEQKEQRAALMVGILIGVFVLCWFPFFV---------TELISPLCSWdVPAIwksiflwLGYSNSFFNPLIYTAFNR 343
Cdd:cd15086 203 ----RKREQHVLLMVVTMVICYLLCWLPYGVmallatfgkPGLVTPVASI-VPSI-------LAKSSTVVNPIIYVFMNK 270

                ....*.
gi 84370345 344 SYSSAF 349
Cdd:cd15086 271 QFYRCF 276
7tmA_prokineticin-R cd15204
prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
58-342 1.48e-12

prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Prokineticins 1 (PROK1) and 2 (PROK2), also known as endocrine gland vascular endothelial factor and Bombina varigata 8, respectively, are multifunctional chemokine-like peptides that are highly conserved across species. Prokineticins can bind with similar affinities to two closely homologous 7-transmembrane G protein coupled receptors, PROKR1 and PROKR2, which are phylogenetically related to the tachykinin receptors. Prokineticins and their GPCRs are widely distributed in human tissues and are involved in numerous physiological roles, including gastrointestinal motility, generation of circadian rhythms, neuron migration and survival, pain sensation, angiogenesis, inflammation, and reproduction. Moreover, different point mutations in genes encoding PROK2 or its receptor (PROKR2) can lead to Kallmann syndrome, a disease characterized by delayed or absent puberty and impaired olfactory function.


Pssm-ID: 320332 [Multi-domain]  Cd Length: 288  Bit Score: 67.30  E-value: 1.48e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  58 NLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSL----VHELSgrrWQLGRRLCqlwIACDVLcCTASIWNVT 133
Cdd:cd15204  18 NLLLIAVLARYKKLRTLTNLLIANLALSDFLVAVFCLPFEMdyyvVRQRS---WTHGDVLC---AVVNYL-RTVSLYVST 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 134 ----AIALDRYWSITRHLeyTLRTRKRVSNVMILLTWALSTVISLAPLLFgwGETYSEPSEE---C-------QVSREPS 199
Cdd:cd15204  91 nallVIAIDRYLVIVHPL--KPRMKRRTACVVIALVWVVSLLLAIPSAVY--SKTTPYANQGkifCgqiwpvdQQAYYKA 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 200 YTVFSTVGAFYLPLCVVLFVYWKIYRAAKFRmgsrktnsvsPVPeavevknatqhpqmvftvrhatvTFQTEGDTWREQK 279
Cdd:cd15204 167 YYLFLFVLEFVLPVLIMTLCYLRIVRKVWFR----------RVP-----------------------GQQTEQIRRRLRR 213
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 84370345 280 EQRAALMVGILIGVFVLCWFPFFVTELI---SPLCSWDVPaIWKSIFLW---LGYSNSFFNPLIYTAFN 342
Cdd:cd15204 214 RRRKVRLLVVILTAFVLCWAPYYGYAIVrdfFPTLLSKEK-LNTTIFYIveaLAMSNSMINTVVYVAFN 281
7tmA_GPR161 cd15214
orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G ...
58-344 1.68e-12

orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR161, an orphan GPCR, is a negative regulator of Sonic hedgehog (Shh) signaling, which promotes the processing of zinc finger protein GLI3 into its transcriptional repressor form (GLI3R) during neural tube development. In the absence of Shh, this proteolytic processing is normally mediated by cAMP-dependent protein kinase A (PKA). GPR161 is recruited to primary cilia by a mechanism depends on TULP3 (tubby-related protein 3) and the intraflagellar complex A (IFT-A). Moreover, Gpr161 knockout mice show phenotypes observed in Tulp3/IFT-A mutants, and cause increased Shh signaling in the neural tube. Taken together, GPR161 negatively regulates the PKA-dependent GLI3 processing in the absence of Shh signal by coupling to G(s) protein, which causes activation of adenylate cyclase, elevated cAMP levels, and activation of PKA. Conversely, in the presence of Shh, GPR161 is removed from the cilia by internalization into the endosomal recycling compartment, leading to downregulation of its activity and thereby allowing Shh signaling to proceed. In addition, GPR161 is over-expressed in triple-negative breast cancer (lacking estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 (HER2) expression) and correlates with poor prognosis. Mutations of GPR161 have also been implicated as a novel cause for pituitary stalk interruption syndrome (PSIS), a rare congenital disease of the pituitary gland. GPR161 is a member of the class A family of GPCRs, which contains receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320342 [Multi-domain]  Cd Length: 261  Bit Score: 66.89  E-value: 1.68e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  58 NLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSgRRWQLGRRLCQLWIACDVLCCTASIWNVTAIAL 137
Cdd:cd15214  17 NLVIVVTLYKKSYLLTLSNKFVFSLTLSNLLLSVLVLPFVVTSSIR-REWIFGVVWCNFSALLYLLISSASMLTLGAIAI 95
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 138 DRYWSITRHLEYTLRTRKRVSNVMILLTWaLSTVISLAPLLFGWGE-TYSEPSEECQVS--REPSYTVFSTVGAFYLPLC 214
Cdd:cd15214  96 DRYYAVLYPMVYPMKITGNRAVLALVYIW-LHSLIGCLPPLFGWSSlEFDRFKWMCVAAwhKEAGYTAFWQVWCALLPFV 174
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 215 VVLFVYWKIYRAAKfrmgsrktnsvspvpeavevknatqhpqmvftvrhatvtfqtegdtwreQKEQRAALMVGILIGVF 294
Cdd:cd15214 175 VMLVCYGFIFRVAR-------------------------------------------------ANQCKAFITILVVLGAF 205
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 84370345 295 VLCWFPFFVteLISPLCSW---DVPAIWKSIFLWLGYSNSFFNPLIYTAFNRS 344
Cdd:cd15214 206 VTTWGPYMV--VISTEALWgknSVSPQLETLATWLSFTSAVCHPLIYGLWNKT 256
7tmA_Mel1B cd15400
melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G ...
45-345 3.93e-12

melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320522 [Multi-domain]  Cd Length: 279  Bit Score: 66.03  E-value: 3.93e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  45 TLLGFLAAATFTWNLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSGRrWQLGRRLCQLWIACDVLC 124
Cdd:cd15400   5 SVLIFTTVVDILGNLLVIISVFRNRKLRNSGNVFVVSLALADLVVALYPYPLVLVAIFHNG-WALGEMHCKVSGFVMGLS 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 125 CTASIWNVTAIALDRYWSITRHLEYTLRTRKRVSNVMILLTWALsTVISLAPLLFGWGETYSEPSEECQVSREPS--YTV 202
Cdd:cd15400  84 VIGSIFNITGIAINRYCYICHSFAYDKLYSRWNTLLYVCLIWAL-TVVAIVPNFFVGSLEYDPRIYSCTFVQTASssYTI 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 203 FSTVGAFYLPLCVVLFVYWKIYraakfrmgsrktnsvspvpeavevknatqhpQMVFTVRHATvtfQTEGDTWREQKEQR 282
Cdd:cd15400 163 AVVVIHFIVPITVVSFCYLRIW-------------------------------VLVIQVRRKV---KSESKPRLKPSDFR 208
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 84370345 283 AALMVGILIGVFVLCWFPFFVTELISPLCSWDV-PAIWKSIFL---WLGYSNSFFNPLIYTAFNRSY 345
Cdd:cd15400 209 NFLTMFVVFVIFAICWAPLNLIGLAVAINPQEMaPKVPEWLFVvsyFMAYFNSCLNAIIYGLLNQNF 275
7tmA_BK-2 cd15381
bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled ...
55-338 6.18e-12

bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320503 [Multi-domain]  Cd Length: 284  Bit Score: 65.17  E-value: 6.18e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  55 FTWNLLVLATI-----LKVRTFHR----VPHNLVASMAISDvLVAVLVMPLSLVHELSGRRWQLGRRLCQLWIACDVLCC 125
Cdd:cd15381   6 YLWIIFVLGTIenafvLIVFCLHKssctVAEIYLGNLAAAD-LLLVCCLPFWAINISNGFNWPFGEFLCKSVNAVIYMNL 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 126 TASIWNVTAIALDRYWSITRHLEYTLRTRKRVSNVMILLTWALSTVISLAPLLFGWGETYSEPSEECQVSREPS--YTVF 203
Cdd:cd15381  85 YSSIYFLMMVSIDRYLALVKTMSSGRMRRPACAKLNCLIIWMFGLLMSTPMIVFRTVMYFPEYNITACVLDYPSegWHVA 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 204 S----TVGAFYLPLCVVLFVYWKIYRAAKfrmgsrktnsvspvpeavevKNATQHPQMVftvrhatvtfqtegdtwreQK 279
Cdd:cd15381 165 LnillNVVGFLIPLSIITFCSTQIIQVLR--------------------NNKMQKFKEI-------------------QT 205
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 84370345 280 EQRAALMVGILIGVFVLCWFPFFVTELIS--------PLCSW-DVPAIWKSIFLWLGYSNSFFNPLIY 338
Cdd:cd15381 206 ERKATVLVLAVLLMFFICWLPFHIFTFLDtlhklgliSGCRWeDILDIGTQIATFLAYSNSCLNPLLY 273
7tmA_Adenosine_R_A3 cd15070
adenosine receptor subtype A3, member of the class A family of seven-transmembrane G ...
58-338 7.76e-12

adenosine receptor subtype A3, member of the class A family of seven-transmembrane G protein-coupled receptors; The A3 receptor, a member of the adenosine receptor family of G protein-coupled receptors, is coupled to G proteins of the inhibitory G(i) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels. The A3 receptor has a sustained protective function in the heart during cardiac ischemia and contributes to inhibition of neutrophil degranulation in neutrophil-mediated tissue injury. Moreover, activation of A3 receptor by adenosine protects astrocytes from cell death induced by hypoxia.


Pssm-ID: 320198 [Multi-domain]  Cd Length: 280  Bit Score: 65.18  E-value: 7.76e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  58 NLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSgrrWQLGRRLCqLWIACDVLCCT-ASIWNVTAIA 136
Cdd:cd15070  18 NVLVIWVVKLNPSLRTTTFYFIVSLALADIAVGVLVIPLAIVVSLG---VTIHFYSC-LFMSCLLVVFThASIMSLLAIA 93
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 137 LDRYWSITRHLEYTLRTRKRVSNVMILLTWALSTVISLAPlLFGW-----GETYSEPSEECQ---VSREPSYTVFSTVGA 208
Cdd:cd15070  94 VDRYLRVKLTVRYRIVTTQRRIWLALGLCWLVSFLVGLTP-MFGWnrkpsLESVNTTPLQCQftsVMRMDYMVYFSFFTW 172
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 209 FYLPLCVVLFVYWKIYRAAKFRMGSRKTnsvspvpeavevknatqhpqmvftvrhatvTFQTEGDTWReqKEQRAALMVG 288
Cdd:cd15070 173 ILIPLVIMCALYVDIFYIIRNKLSQNAT------------------------------GFRETGAFYG--REFKTAKSLA 220
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 84370345 289 ILIGVFVLCWFPFFVTELISPLCSwDVPAIWKSIFLWLGYSNSFFNPLIY 338
Cdd:cd15070 221 LVLFLFAVCWLPLSIINCVVYFNP-KVPKIALYLGILLSHANSMMNPIVY 269
7tmA_SSTR4 cd15973
somatostatin receptor type 4, member of the class A family of seven-transmembrane G ...
58-349 9.18e-12

somatostatin receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR4 plays a critical role in mediating inflammation. Unlike other SSTRs, SSTR4 subtype is not detected in all pituitary adenomas while it is expressed in the normal human pituitary.


Pssm-ID: 320639 [Multi-domain]  Cd Length: 274  Bit Score: 64.88  E-value: 9.18e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  58 NLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELsgRRWQLGRRLCQLWIACDVLCCTASIWNVTAIAL 137
Cdd:cd15973  18 NSMVIFVILRYAKMKTATNIYILNLAIADELFMLSVPFLAASAAL--QHWPFGSAMCRTVLSVDGINMFTSVFCLTVLSV 95
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 138 DRYWSITRHLEYTLRTRKRVSNVMILLTWALSTVISLAPLLFGWGETYSEPSEECQV-----SREPSYTVFSTVGAFYLP 212
Cdd:cd15973  96 DRYIAVVHPLRAARYRRPTVAKMINICVWILSLLVISPIIIFADTATRKGQAVACNLiwphpAWSAAFVIYTFLLGFLLP 175
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 213 LCVVLFVYwkIYRAAKFRmgsrktnsvspvpeAVEVKNATQHpqmvftvrhatvtfqtegdtwREQKEQRAALMVGILIG 292
Cdd:cd15973 176 VLAIGLCY--ILIIGKMR--------------AVALKAGWQQ---------------------RRKSEKKITRMVLMVVT 218
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 84370345 293 VFVLCWFPFFVTELISpLCSWDVPAIWKSIFLWLGYSNSFFNPLIYTAFNRSYSSAF 349
Cdd:cd15973 219 VFVICWMPFYVVQLLN-LFLPRLDATVNHASLILSYANSCANPILYGFLSDNFRRSF 274
7tmA_LPAR3_Edg7 cd15343
lysophosphatidic acid receptor subtype 3 (LPAR3 or LPA3), also called endothelial ...
41-339 9.22e-12

lysophosphatidic acid receptor subtype 3 (LPAR3 or LPA3), also called endothelial differentiation gene 7 (Edg7), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320465 [Multi-domain]  Cd Length: 274  Bit Score: 64.90  E-value: 9.22e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  41 VLVLTLLGFLAAATFTWNLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPL-----SLVHELSGRRWQLGRRLCQ 115
Cdd:cd15343   1 IIVLCVGTFCCLFIFVSNSLVIAAVVKNKRFHYPFYYLLANLAAADFFAGIAYVFLmfntgPVSKTLTVNRWFLRQGLLD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 116 LWIacdvlccTASIWNVTAIALDRYWSITRHLEYTLRTRKRVSnVMILLTWALSTVISLAPLLfGWG---ETYSEPSEEC 192
Cdd:cd15343  81 TSL-------SASLTNLLVIAVERHISIMRMKVHSNLTKRRVT-LLIALVWAIAIFMGAVPTL-GWNcicNISACSSLAP 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 193 QVSRepSYTVFSTVGAFYLPLcVVLFVYWKIYRAAKfrmgsRKTNSVSPvpeavevknatqhpqmvftvrhatvtfQTEG 272
Cdd:cd15343 152 IYSR--SYLVFWSVSNLVVFL-IMVVVYLRIYVYVQ-----RKTNVLSP---------------------------HTSG 196
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 84370345 273 DTWREQKEQRAALMVGILIGVFVLCWFPFFVTELISPL-CSWDVPAIWKSIFLWLGYSNSFFNPLIYT 339
Cdd:cd15343 197 SINRRRTPIKLMKTVMTVLGAFVICWTPGLVVLLLDGLnCTRCGVQHVKRWFLLLALLNSVMNPIIYS 264
7tmA_MCHR1 cd15338
melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane ...
41-349 1.09e-11

melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320460 [Multi-domain]  Cd Length: 282  Bit Score: 64.45  E-value: 1.09e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  41 VLVLTLLGFLAAATFTWNLLVLATILKVRTFH---RVPHNLVASMAISDVLVaVLVMPLsLVHELSGR-RWQLGRRLCQL 116
Cdd:cd15338   1 VIMPSVFGVICFLGIIGNSIVIYTIVKKSKFRcqqTVPDIFIFNLSIVDLLF-LLGMPF-LIHQLLGNgVWHFGETMCTL 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 117 WIACDVLCCTASIWNVTAIALDRYWSITRHLEYTLRTRKRVSNVMILLTWALStVISLAPL------------LFGWGET 184
Cdd:cd15338  79 ITALDTNSQITSTYILTVMTLDRYLATVHPIRSTKIRTPRVAVAVICLVWILS-LLSITPVwmyaglmplpdgSVGCALL 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 185 YSEPSEECQvsrepSYTVFSTVGAFYLPLCVVLFVYWKIYRaakfrmgsRKTNSVSPVPeavevknatQHPQMVftvrha 264
Cdd:cd15338 158 LPNPETDTY-----WFTLYQFFLAFALPLVVICVVYFKILQ--------NMASTVAPLP---------QRSLRV------ 209
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 265 tvtfqtegdtwREQKEQRAALMVGIligVFVLCWFPFFVTELISplCSWDVPAI----WKSIFLWLGYSNSFFNPLIYTA 340
Cdd:cd15338 210 -----------RTKKVTRMAVAICL---AFFICWAPFYILQLAH--LSIDRPSLaflyAYNVAISMGYANSCINPFLYIM 273

                ....*....
gi 84370345 341 FNRSYSSAF 349
Cdd:cd15338 274 LSETFKRQF 282
7tmA_GnRHR_vertebrate cd15383
vertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
39-341 1.17e-11

vertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320505 [Multi-domain]  Cd Length: 295  Bit Score: 64.70  E-value: 1.17e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  39 FRVLVlTLLGFLAAATFtwNLLVLATILKVRTFHRVPHN-LVASMAISDVLVAVLVMPLSLVHELSgRRWQLGRRLCQLW 117
Cdd:cd15383   2 VRVAV-TFVLFVLSACS--NLAVLWSATRNRRRKLSHVRiLILHLAAADLLVTFVVMPLDAAWNVT-VQWYAGDLACRLL 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 118 IACDVLCCTASIWNVTAIALDRYWSITRHLEyTLRTRKRvSNVMILLTWALSTVISLaPLLFGWGETYSEPSE---EC-- 192
Cdd:cd15383  78 MFLKLFAMYSSAFVTVVISLDRHAAILNPLA-IGSARRR-NRIMLCAAWGLSALLAL-PQLFLFHTVTATPPVnftQCat 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 193 -----QVSREPSYTVFSTVGAFYLPLCVVLFVYWKIYRAAKFRMgsRKTNSVSPVPEAVEVKNAtqhpqMVFTVRHATVt 267
Cdd:cd15383 155 hgsfpAHWQETLYNMFTFFCLFLLPLLIMIFCYTRILLEISRRM--KEKKDSAKNEVALRSSSD-----NIPKARMRTL- 226
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 84370345 268 fqtegdtwreqkeqraaLMVGILIGVFVLCWFPFFVTEL---ISPLCSWDV--PAIWKSIFLWlGYSNSFFNPLIYTAF 341
Cdd:cd15383 227 -----------------KMTIVIVSSFIVCWTPYYLLGLwywFSPEMLEQTvpESLSHILFLF-GLLNACLDPLIYGLF 287
7tmA_Prostanoid_R cd14981
G protein-coupled receptors for prostanoids, member of the class A family of ...
58-178 1.94e-11

G protein-coupled receptors for prostanoids, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320112 [Multi-domain]  Cd Length: 288  Bit Score: 63.80  E-value: 1.94e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  58 NLLVLATILKVRTFHR--VPHNLVASMAISDVLVAVLVMPLSLVHELSGRRWQLGRRLCQL--WIACDVLCCTASIwnVT 133
Cdd:cd14981  18 NLLALIVLARSSKSHKwsVFYRLVAGLAITDLLGILLTSPVVLAVYASNFEWDGGQPLCDYfgFMMSFFGLSSLLI--VC 95
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 84370345 134 AIALDRYWSITRHLEYTLRTRKRVSNVMILLTWALSTVISLAPLL 178
Cdd:cd14981  96 AMAVERFLAITHPFFYNSHVKKRRARLMLGAVWAFALLIASLPLL 140
7tmA_SSTR3 cd15972
somatostatin receptor type 3, member of the class A family of seven-transmembrane G ...
58-349 2.11e-11

somatostatin receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR3 is coupled to inward rectifying potassium channels. SSTR3 plays critical roles in growth hormone secretion, endothelial cell cycle arrest and apoptosis. Furthermore, SSTR3 is expressed in the normal human pituitary and in nearly half of pituitary growth hormone adenomas.


Pssm-ID: 320638 [Multi-domain]  Cd Length: 279  Bit Score: 63.67  E-value: 2.11e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  58 NLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSgrRWQLGRRLCQLWIACDVLCCTASIWNVTAIAL 137
Cdd:cd15972  18 NTLVIYVVLRYSASESVTNIYILNLALADELFMLGLPFLAAQNALS--YWPFGSFMCRLVMTVDAINQFTSIFCLTVMSV 95
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 138 DRYWSITRHLEYTLRTRKRVSNVMILLTWALSTVISLAPLLF-----GWGETYSEPSEECQVSREPSYTVFSTVGaFYLP 212
Cdd:cd15972  96 DRYLAVVHPIRSSKWRKPPVAKTVNATVWALSFLVVLPVVIFsgvpgGMGTCHIAWPEPAQVWRAGFIIYTATLG-FFCP 174
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 213 LCVVLFVYWKIyrAAKFRMGSRKTNSVSpvpeavevknatqhpqmvftvrhatvtfqtegdTWREQKEQRAALMVGILIG 292
Cdd:cd15972 175 LLVICLCYLLI--VVKVRSSGRRVRATS---------------------------------TKRRGSERKVTRMVVIVVA 219
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 293 VFVLCWFPFFVTELISPLCSWDVPAIWKSIFLW---LGYSNSFFNPLIYTAFNRSYSSAF 349
Cdd:cd15972 220 AFVLCWLPFYALNIVNLVCPLPEEPSLFGLYFFvvvLSYANSCANPIIYGFLSDNFKQGF 279
7tmA_OXR cd15208
orexin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
58-339 5.85e-11

orexin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Orexins (OXs, also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. Thus, activation of OX1R or OX2R will activate phospholipase activity and the phosphatidylinositol and calcium signaling pathways. Additionally, OX2R activation can also lead to inhibition of adenylate cyclase.


Pssm-ID: 320336 [Multi-domain]  Cd Length: 303  Bit Score: 62.79  E-value: 5.85e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  58 NLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSgRRWQLGRRLCQLWIACDVLCCTASIWNVTAIAL 137
Cdd:cd15208  18 NVLVCFAVWRNHHMRTVTNYFIVNLSLADFLVIIICLPATLLVDVT-ETWFFGQVLCKIIPYLQTVSVSVSVLTLSCIAL 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 138 DRYWSITRHLEYTLrTRKRvSNVMILLTWALSTVISL-----------------APLLFGWGETYSEPSEEcqvsrePSY 200
Cdd:cd15208  97 DRWYAICHPLMFKS-TAKR-ARVSILIIWIVSLLIMIpqaivmecsrvvplankTILLTVCDERWSDSIYQ------KVY 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 201 TVFSTVGAFYLPLCVVLFVYWKIYRaakfRMGSRKTnsvsPVPEAVEVKNATQHpqmvftvRHATVTFQtegdtwREQKE 280
Cdd:cd15208 169 HICFFLVTYLLPLCLMILAYFQIFR----KLWCRQI----PGTSSVVQRKWNKP-------RKSAVAAE------EKQLR 227
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 84370345 281 QR--AALMVGILIGVFVLCWFP---FFVTELISPLCSWDVPAI--WKSIFLWLGYSNSFFNPLIYT 339
Cdd:cd15208 228 SRrkTAKMLIVVVIMFAICYLPvhlLNILRYVFGLFTVDRETIyaWFLFSHWLVYANSAINPIIYN 293
7tmA_Apelin_R cd15190
apelin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
58-348 7.71e-11

apelin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Apelin (APJ) receptor is a G protein-coupled receptor that binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake.


Pssm-ID: 341340 [Multi-domain]  Cd Length: 304  Bit Score: 62.09  E-value: 7.71e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  58 NLLVLATILKVRT-FHRVPHNLVASMAISDvLVAVLVMPLSLVHELSGRRWQLGRRLCQLWIACDVLCCTASIWNVTAIA 136
Cdd:cd15190  28 NGLVLWTVFRSKRkRRRSADTFIANLALAD-LTFVVTLPLWAVYTALGYHWPFGSFLCKLSSYLVFVNMYASVFCLTGLS 106
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 137 LDRYWSITRHLEYTlRTRKRVSNVMIL-LTWALSTVISLAPLLFGWGETYSEP-------------SEECQVSREPSYTV 202
Cdd:cd15190 107 FDRYLAIVRSLASA-KLRSRTSGIVALgVIWLLAALLALPALILRTTSDLEGTnkvicdmdysgvvSNESEWAWIAGLGL 185
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 203 FSTVGAFYLPLCVVLFVYWKIYR--AAKFRMGSRKtnsvspvpeavevknatqhpqmvftvrhatvtfqtegdtwrEQKE 280
Cdd:cd15190 186 SSTVLGFLLPFLIMLTCYFFIGRtvARHFSKLRRK-----------------------------------------EDKK 224
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 84370345 281 QRAALMVGI-LIGVFVLCWFPFFVTELISPLCSWDVPAIWKSIFLWL----------GYSNSFFNPLIYTAFNRSYSSA 348
Cdd:cd15190 225 KRRLLKIIItLVVTFALCWLPFHLVKTLYALMYLGILPFSCGFDLFLmnahpyatclAYVNSCLNPFLYAFFDPRFRQQ 303
7tmA_S1PR cd15102
sphingosine-1-phosphate receptors, member of the class A family of seven-transmembrane G ...
58-349 8.88e-11

sphingosine-1-phosphate receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320230 [Multi-domain]  Cd Length: 270  Bit Score: 61.72  E-value: 8.88e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  58 NLLVLATILKVRTFHRVPHNLVASMAISDVL-----VAVLVMPLSLVHELSGRRWQLgrRLCQLWIAcdvlcCTASIWNV 132
Cdd:cd15102  18 NLLVLIAIWRHMKFHRPMYYFLGNLALSDLLagaayLANILLSGARTLRLSPAQWFL--REGSMFVA-----LSASVFSL 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 133 TAIALDRYWSITRHLEYTLRTRKRVSnVMILLTWALSTVISLAPLLfGWgetysepseECQVSREPSYTVFSTVGAFYLP 212
Cdd:cd15102  91 LAIAIERHLTMAKMKPYGASKTSRVL-LLIGACWLISLLLGGLPIL-GW---------NCLGALDACSTVLPLYSKHYVL 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 213 LCVVLFV---------YWKIYRAAKFRmgsrktnsvspvpeAVEVKNATQHPQMVFTVRhaTVTfqtegdtwreqkeqra 283
Cdd:cd15102 160 FCVTIFAgilaaivalYARIYCLVRAS--------------GRKATRASASPRSLALLK--TVL---------------- 207
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 84370345 284 almvgILIGVFVLCWFPFFVTELISPLCS-WDVPAIWKS-IFLWLGYSNSFFNPLIYTAFNRSYSSAF 349
Cdd:cd15102 208 -----IVLLVFIACWGPLFILLLLDVACPvKTCPILYKAdWFLALAVLNSALNPIIYTLRSRELRRAV 270
7tmA_CCK_R cd15206
cholecystokinin receptors, member of the class A family of seven-transmembrane G ...
41-349 9.65e-11

cholecystokinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320334 [Multi-domain]  Cd Length: 269  Bit Score: 61.64  E-value: 9.65e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  41 VLVLTLLGflaaatftwNLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSgRRWQLGRRLCQLWIAC 120
Cdd:cd15206  10 IFLLAVVG---------NILVIVTLVQNKRMRTVTNVFLLNLAVSDLLLAVFCMPFTLVGQLL-RNFIFGEVMCKLIPYF 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 121 DVLCCTASIWNVTAIALDRYWSITRHLEYTLRTRKRVSNVMILLTWALSTVISLAPLLFGWGETYSEP-SEECQV----- 194
Cdd:cd15206  80 QAVSVSVSTFTLVAISLERYFAICHPLKSRVWQTLSHAYKVIAGIWLLSFLIMSPILVFSNLIPMSRPgGHKCREvwpne 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 195 SREPSYTVFSTVGAFYLPLCVVLFVYWKIYRaakfrmgsrktnsvspvpeavevknatqhpqmvftvrhatvtfqtegdT 274
Cdd:cd15206 160 IAEQAWYVFLDLMLLVIPGLVMSVAYGLISW------------------------------------------------T 191
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 275 WREQKeQRAALMVGILIGVFVLCWFPFFVtelISPLCSWDVPAIWK-------SIFLWLGYSNSFFNPLIYTAFNRSYSS 347
Cdd:cd15206 192 LLEAK-KRVIRMLFVIVVEFFICWTPLYV---INTWKAFDPPSAARyvssttiSLIQLLAYISSCVNPITYCFMNKRFRQ 267

                ..
gi 84370345 348 AF 349
Cdd:cd15206 268 AF 269
7tmA_SSTR5 cd15974
somatostatin receptor type 5, member of the class A family of seven-transmembrane G ...
41-349 1.16e-10

somatostatin receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR5 is coupled to inward rectifying K channels and phospholipase C, and plays critical roles in growth hormone and insulin secretion. SSTR5 acts as a negative regulator of PDX-1 (pancreatic and duodenal homeobox-1) expression, which is a conserved homeodomain-containing beta cell-specific transcription factor essentially involved in pancreatic development, among many other functions.


Pssm-ID: 320640 [Multi-domain]  Cd Length: 277  Bit Score: 61.36  E-value: 1.16e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  41 VLVLTLLGFLAAATFTWNLLVLATILKVRTFHRVPHNLVASMAISDVLVaVLVMPLsLVHELSGRRWQLGRRLCQLWIAC 120
Cdd:cd15974   1 VLIPVIYLLVCAIGLSGNTLVIYVVLRYAKMKTVTNIYILNLAVADELF-MLGLPF-LATQNAISYWPFGSFLCRLVMTV 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 121 DVLCCTASIWNVTAIALDRYWSITRHLEYTLRTRKRVSNVMILLTWALSTVISLAPLLFGwgeTYSEPSEECQVS-REP- 198
Cdd:cd15974  79 DGVNQFTSIFCLTVMSIDRYLAVVHPIKSTKWRRPRVAKLINATVWTLSFLVVLPVIIFS---DVQPDLNTCNISwPEPv 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 199 -----SYTVFSTVGAFYLPLCVVLFVYWKI---YRAAKFRMGSRKtnsvspvpeavevknatqhpqmvftvrhatvtfqt 270
Cdd:cd15974 156 svwstAFIIYTAVLGFFGPLLVICLCYLLIvikVKSSGLRVGSTK----------------------------------- 200
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 271 egdtwREQKEQRAALMVGILIGVFVLCWFPFFVTELISPLCSWDVPAIWKSIFLW---LGYSNSFFNPLIYTAFNRSYSS 347
Cdd:cd15974 201 -----RRKSERKVTRMVVIIVVVFVFCWLPFYMLNIVNLIVILPEEPAFVGVYFFvvvLSYANSCANPILYGFLSDNFKQ 275

                ..
gi 84370345 348 AF 349
Cdd:cd15974 276 SF 277
7tmA_NPY1R cd15395
neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G ...
58-303 2.57e-10

neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320517 [Multi-domain]  Cd Length: 293  Bit Score: 60.60  E-value: 2.57e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  58 NLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSGrRWQLGRRLCQLWIACDVLCCTASIWNVTAIAL 137
Cdd:cd15395  18 NLALIIIILKQKEMHNVTNILIVNLSFSDLLMTIMCLPFTFVYTLMD-HWVFGEAMCKLNSMVQCISITVSIFSLVLIAI 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 138 DRYWSITRHLEYtlRTRKRVSNVMILLTWALSTVISLAPLLFgwGETYSEPSEECQVSREP------------------S 199
Cdd:cd15395  97 ERHQLIINPRGW--RPNNRHAYVGIAVIWVLAVLTSLPFLIF--QVLTDEPFKNVNVSLDAykgkyvcldqfpsdtirlS 172
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 200 YTVFSTVGAFYLPLCVVLFVYWKIYRAAKfrmgsRKTNSVSPVPEavevknatqhpqmvftvrhatvtfqtegDTWREQK 279
Cdd:cd15395 173 YTTCLLVLQYFGPLCFIFICYLKIYIRLK-----RRNNMMDKMRD----------------------------NKYRSSE 219
                       250       260
                ....*....|....*....|....
gi 84370345 280 EQRAALMVGILIGVFVLCWFPFFV 303
Cdd:cd15395 220 TKRINIMLISIVVAFAVCWLPLNI 243
7tmA_Mu_opioid_R cd15090
opioid receptor subtype mu, member of the class A family of seven-transmembrane G ...
41-349 2.90e-10

opioid receptor subtype mu, member of the class A family of seven-transmembrane G protein-coupled receptors; The mu-opioid receptor binds endogenous opioids such as beta-endorphin and endomorphin. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320218 [Multi-domain]  Cd Length: 279  Bit Score: 60.39  E-value: 2.90e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  41 VLVLTLLGFLAAATFTWNLLVLATILKVRTFHRVPHNLVASMAISDVLvAVLVMPLSLVHELSGRrWQLGRRLCQLWIAC 120
Cdd:cd15090   1 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADAL-ATSTLPFQSVNYLMGT-WPFGNILCKIVISI 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 121 DVLCCTASIWNVTAIALDRYWSITRHLEYTLRTRKRVSNVMILLTWALSTVISLaPLLFGWGETYSEPSEECQVS-REPS 199
Cdd:cd15090  79 DYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGL-PVMFMATTKYRQGSIDCTLTfSHPS 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 200 Y------TVFSTVGAFYLPLCVVLFVY-WKIYRAAKFRMGSrktnsvspvpeavevknatqhpqmvftvrhatvtfqteG 272
Cdd:cd15090 158 WywenllKICVFIFAFIMPVLIITVCYgLMILRLKSVRMLS--------------------------------------G 199
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 273 DTWREQKEQRAALMVGILIGVFVLCWFPFFVTELISPLCSwdVPAIWKSIFLW-----LGYSNSFFNPLIYTAFNRSYSS 347
Cdd:cd15090 200 SKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVT--IPETTFQTVSWhfciaLGYTNSCLNPVLYAFLDENFKR 277

                ..
gi 84370345 348 AF 349
Cdd:cd15090 278 CF 279
7tmA_Angiotensin_R-like cd14985
angiotesin receptor family and its related G protein-coupled receptors, member of the class A ...
55-349 3.10e-10

angiotesin receptor family and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the angiotensin receptors, the bradykinin receptors, apelin receptor as well as putative G-protein coupled receptors (GPR15 and GPR25). Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2 receptor, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Bradykinins (BK) are pro-inflammatory peptides that mediate various vascular and pain responses to tissue injury through its B1 and B2 receptors. Apelin (APJ) receptor binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body, and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake. Orphan receptors, GPR15 and GPR25, share strong sequence homology to the angiotensin II type AT1 and AT2 receptors.


Pssm-ID: 341320 [Multi-domain]  Cd Length: 284  Bit Score: 60.08  E-value: 3.10e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  55 FTWNLLVLATILKVRTFHRVPHNLVASMAISDvLVAVLVMPLSLVHELSGRRWQLGRRLCQLWIACDVLCCTASIWNVTA 134
Cdd:cd14985  15 LLGNLFVVWVFLFPRGPKRVADIFIANLAAAD-LVFVLTLPLWATYTANQYDWPFGAFLCKVSSYVISVNMFASIFLLTC 93
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 135 IALDRYWSITRHLEYTLRTRKRVSNVMILLTWALSTVISLAPLLFGwGETYSEPSEECQVSREPSYT-------VFSTVG 207
Cdd:cd14985  94 MSVDRYLAIVHPVASRRLRRRRQARVTCALIWVVACLLSLPTFLLR-SLQAIENLNKTACIMLYPHEawhfglsLELNIL 172
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 208 AFYLPLCVVLFVYWKIYRAAKfrmgsrktnsvspvpeavevknatqhpqmvftvrhatvtfQTEGDTWREQKEQRAAL-M 286
Cdd:cd14985 173 GFVLPLLIILTCYFHIARSLR----------------------------------------KRYERTGKNGRKRRKSLkI 212
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 84370345 287 VGILIGVFVLCWFPFFVTELISPLCSWDV--PAIWKSIFLW-------LGYSNSFFNPLIYTAFNRSYSSAF 349
Cdd:cd14985 213 IFALVVAFLVCWLPFHFFKFLDFLAQLGAirPCFWELFLDLglpiatcLAFTNSCLNPFIYVFVDRRFRQKV 284
7tmA_Parapinopsin cd15075
non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled ...
45-346 3.33e-10

non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the non-visual pineal pigment, parapinopsin, which is a member of the class A of the seven transmembrane G protein-coupled receptors. Parapinopsin serves as a UV-sensitive pigment for the wavelength discrimination in the pineal-related organs of lower vertebrates such as reptiles, amphibians, and fish. Although parapinopsin is phylogenetically related to vertebrate visual pigments such as rhodopsin, which releases its retinal chromophore and bleaches, the parapinopsin photoproduct is stable and does not bleach. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells.


Pssm-ID: 320203 [Multi-domain]  Cd Length: 279  Bit Score: 60.18  E-value: 3.33e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  45 TLLGFLAAATFTWNLLVLATILKVRTFH---RVPHNL-VASMAISDVLVAVLVMPLSLVHELSGRrWQLGRRLCQLWIAC 120
Cdd:cd15075   1 TILSIIMAVFSIASVVLNATVIIVTLRHkqlRQPLNYaLVNLAVADLGTTVFGGLLSVVTNAVGY-FNLGRVGCVLEGFA 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 121 DVLCCTASIWNVTAIALDRYWSITRHLEyTLRTRKRVSNVMILLTWALSTVISLAPlLFGWGETYSE-PSEECQ---VSR 196
Cdd:cd15075  80 VAFFGIAALCTVAVIAVDRLFVVCKPLG-TLTFQTRHALAGIASSWLWSLIWNTPP-LFGWGSYQLEgVMTSCApdwYSR 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 197 EP---SYTVFSTVGAFYLPLCVVLFVY----WKIYRAAKFRMGSRKTNSvspvpeavevknatqhpqmvftvrhatvtfq 269
Cdd:cd15075 158 DPvnvSYILCYFSFCFAIPFAIILVSYgyllWTLRQVAKLGVAEGGSTA------------------------------- 206
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 270 tegdtwreQKEQRAALMVGILIGVFVLCWFP---FFVTELISPLCSWDVpaIWKSIFLWLGYSNSFFNPLIYTAFNRSYS 346
Cdd:cd15075 207 --------KAEVQVARMVVVMVMAFLLCWLPyaaFALTVVSKPDVYINP--LIATVPMYLAKSSTVYNPIIYIFMNKQFR 276
7tmA_NKR_NK3R cd16003
neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
48-349 4.05e-10

neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin-K receptor (NKR), also known as tachykinin receptor 3 (TACR3) or neurokinin B receptor or NK3R, is a G-protein coupled receptor that specifically binds to neurokinin B. The tachykinins (TKs) act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320669 [Multi-domain]  Cd Length: 282  Bit Score: 59.94  E-value: 4.05e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  48 GFLAAATFTWNLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSGRrWQLGRRLCQLWIACDVLCCTA 127
Cdd:cd16003   8 GFVVAVAVFGNLIVIWIILAHKRMRTVTNYFLVNLAFSDASMAAFNTLINFIYALHSE-WYFGEAYCRFHNFFPITSVFA 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 128 SIWNVTAIALDRYWSITRHLEytLRTRKRVSNVMILLTWALSTVISLAPLLFgwGETYSEPSEECQVSREPSytvfSTVG 207
Cdd:cd16003  87 SIYSMTAIAVDRYMAIIDPLK--PRLSATATKVVIGSIWILAFLLAFPQCLY--SKTKVMPGRTLCFVAWPG----GPDQ 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 208 AFYLPLCVVLFVYWkiyraakfrmgsrktnsvspvpeavevknatqHPQMVFTVRHATVTF-----QTEGDTWREQKEQ- 281
Cdd:cd16003 159 HFTYHIIVIVLVYC--------------------------------LPLLVMGITYTIVGItlwggEIPGDTSDKYHEQl 206
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 84370345 282 ----RAALMVGILIGVFVLCWFP----FFVTELISPLCSWD-VPAIWKSIFlWLGYSNSFFNPLIYTAFNRSYSSAF 349
Cdd:cd16003 207 rakrKVVKMMIIVVLTFAICWLPyhiyFIVTGLYQQLNRWKyIQQVYLASF-WLAMSSTMYNPIIYCCLNKRFRAGF 282
7tmA_S1PR5_Edg8 cd15348
sphingosine-1-phosphate receptor subtype 5 (S1PR5 or S1P5), also called endothelial ...
58-348 4.78e-10

sphingosine-1-phosphate receptor subtype 5 (S1PR5 or S1P5), also called endothelial differentiation gene 8 (Edg8), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320470 [Multi-domain]  Cd Length: 277  Bit Score: 59.45  E-value: 4.78e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  58 NLLVLATILKVRTFHRVPHNLVASMAISDVLVAV-----LVMPLSLVHELSGRRWQLgrRLCQLWIAcdvlcCTASIWNV 132
Cdd:cd15348  18 NLIVLLALWRNKKFHSPMFYLLGSLTLSDLLAGAayaanILMSGANTLKLTPALWFL--REGGVFIT-----LTASVFSL 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 133 TAIALDRYWSITRHLEYTLRTRKRVSnVMILLTWALSTVISLAPLLfGWgetysepseECQVSREPSYTVFSTVGAFYLP 212
Cdd:cd15348  91 LAIAIERHITMVRMKPYPGDKRGRMF-LLIGAAWLVSILLGVLPIL-GW---------NCLGNLDACSTVLPLYAKSYIL 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 213 LCVVLFV---------YWKIYRAAKF---RMGSRKtnsvspvpeavevknatqhpqmvftvrhatvtfQTEGDTWREQKE 280
Cdd:cd15348 160 FCITVFLailaaivvlYARIYRIVKAnsqRLGALP---------------------------------TRKGRARRSQKY 206
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 281 QRAALMVGILIGVFVLCWFPFFVTELISPLCSWDV-PAIWKS-IFLWLGYSNSFFNPLIYTAFNRSYSSA 348
Cdd:cd15348 207 LALLKTVTIVLGTFVACWLPLFLLLLLDVSCPAQAcPVLLKAdYFLGLAMINSLLNPIIYTLTSRDMRRA 276
7tmA_V2R cd15388
vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled ...
44-347 5.30e-10

vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The vasopressin type 2 receptor (V2R) is a G(s)-coupled receptor that controls balance of water and sodium ion by regulating their reabsorption in the renal collecting duct. Mutations of V2R is responsible for nephrogenic diabetes insipidus. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320510 [Multi-domain]  Cd Length: 295  Bit Score: 59.79  E-value: 5.30e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  44 LTLLGFLAAATFTWNLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSGRrWQLGRRLCQLWIACDVL 123
Cdd:cd15388   4 IAVLAIIFACALLSNSLVLLVLWRRRKQLARMHVFMLHLCIADLVVAFFQVLPQLVWDITDR-FRGPDVLCRLVKYLQVV 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 124 CCTASIWNVTAIALDRYWSITRHLEyTLRTRKRVSNVMILLTWALSTVISLaPLLFGWGETYSEPS-EECQVS-REP--- 198
Cdd:cd15388  83 GMFASSYMIVAMTFDRHQAICRPMV-TFQKGRARWNGPVCVAWAISLILSL-PQVFIFSKVEVAPGvYECWACfIEPwgl 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 199 -SYTVFSTVGAFYLPLCVVLFVYWKIYRAAKFRMGSRKTNSVSpvpeavEVKNATQHPQMVFTVRHATVTFQtegdtwre 277
Cdd:cd15388 161 kAYVTWITLVVFVLPTLIITVCQVLIFKEIHINIYLKSQIIVA------VVKKKQLLSSRASSVAEVSKAMI-------- 226
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 84370345 278 qkeqRAALMVGILIGVFVLCWFPFFVTELISplcSWDVPAIWK----SIFLWLGYSNSFFNPLIYTAFNRSYSS 347
Cdd:cd15388 227 ----KTVKMTLVIVLVYVLCWAPFFLVQLWS---VWDPKAPTEgatfTILMLLASLNSCTNPWIYMAFSSSVSK 293
7tmA_S1PR1_Edg1 cd15346
sphingosine-1-phosphate receptor subtype 1 (S1PR1 or S1P1), also called endothelial ...
58-349 5.39e-10

sphingosine-1-phosphate receptor subtype 1 (S1PR1 or S1P1), also called endothelial differentiation gene 1 (Edg1), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320468 [Multi-domain]  Cd Length: 277  Bit Score: 59.50  E-value: 5.39e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  58 NLLVLATILKVRTFHRVPHNLVASMAISDVLVAV-----LVMPLSLVHELSGRRWQLgrRLCQLWIAcdvlcCTASIWNV 132
Cdd:cd15346  18 NIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVaytanLLLSGATTYKLTPTQWFL--REGSMFVA-----LSASVFSL 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 133 TAIALDRYWSItrhLEYTLRTRKRVSNVMILLT--WALSTVISLAPLLfGWGETYSEPSEECQVSREPSYTVFSTVGAFY 210
Cdd:cd15346  91 LAIAIERYITM---LKMKLHNGSNSFRSFLLISacWVISLILGGLPIM-GWNCISALSSCSTVLPLYHKHYILFCTTVFT 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 211 LPLCVVLFVYWKIYRAAKFRmgSRKtnsvspvpeavevknatqhpqmvftvrhatVTFQTEGDTWREQKEQRAALM--VG 288
Cdd:cd15346 167 LLLLSIVILYCRIYSLVRTR--SRR------------------------------LTFRKNIRKASRSSEKSMALLktVI 214
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 84370345 289 ILIGVFVLCWFPFFVTELISPLCSWDV-PAIWKS-IFLWLGYSNSFFNPLIYTAFNRSYSSAF 349
Cdd:cd15346 215 IVLSVFIACWAPLFILLLLDVGCKVKTcSILFKAeYFLVLAVLNSATNPIIYTLTNKEMRRAF 277
7tmA_Chemokine_R cd14984
classical and atypical chemokine receptors, member of the class A family of ...
34-341 5.41e-10

classical and atypical chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. In addition to these classical chemokine receptors, there exists a subfamily of atypical chemokine receptors (ACKRs) that are unable to couple to G-proteins and, instead, they preferentially mediate beta-arrestin dependent processes, such as receptor internalization, after ligand binding. The classical chemokine receptors contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. However, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 341319 [Multi-domain]  Cd Length: 278  Bit Score: 59.54  E-value: 5.41e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  34 PFLSAFRVLVLtLLGFLAaatftwNLLVLATILKVRTFHRVPHNLVASMAISDvLVAVLVMPLSLVHELSGrrWQLGRRL 113
Cdd:cd14984   1 VFLPVLYSLVF-LLGLVG------NSLVLLVLLYYRKLRSMTDVYLLNLALAD-LLFVLTLPFWAVYAADG--WVFGSFL 70
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 114 CQLWIACDVLCCTASIWNVTAIALDRYWSITrHLEYTLRTRKRVSNVMI-LLTWALSTVISLAPLLFG--------WGET 184
Cdd:cd14984  71 CKLVSALYTINFYSGILFLACISIDRYLAIV-HAVSALRARTLLHGKLTcLGVWALALLLSLPEFIFSqvseengsSICS 149
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 185 YSEPSEECQVSREPSyTVFSTVGAFYLPLCVVLFVYWKIYRaakfrmgsrktnsvspvpeavevknatqhpqmvfTVRHA 264
Cdd:cd14984 150 YDYPEDTATTWKTLL-RLLQNILGFLLPLLVMLFCYSRIIR----------------------------------TLLRA 194
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 265 tvtfqtegdtwREQKEQRAALMVGILIGVFVLCWFPFFVTELISPLCSWDVPA----------IWKSIFLWLGYSNSFFN 334
Cdd:cd14984 195 -----------RNHKKHRALRVIFAVVVVFFLCWLPYNIVLLLDTLQLLGIISrscelsksldYALQVTESLAFSHCCLN 263

                ....*..
gi 84370345 335 PLIYtAF 341
Cdd:cd14984 264 PVLY-AF 269
7tmA_motilin_R cd15132
motilin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
64-348 8.45e-10

motilin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Motilin receptor, also known as GPR38, is a G-protein coupled receptor that binds the endogenous ligand motilin. Motilin is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. Motilin is also called as the housekeeper of the gut because it is responsible for the proper filling and emptying of the gastrointestinal tract in response to food intake, and for stimulating the production of pepsin. Motilin receptor shares significant amino acid sequence identity with the growth hormone secretagogue receptor (GHSR) and neurotensin receptors (NTS-R1 and 2).


Pssm-ID: 320260 [Multi-domain]  Cd Length: 289  Bit Score: 59.04  E-value: 8.45e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  64 TILKVRTFH--RVPHNL-VASMAISDVLVaVLVMPLSLVHELSGRRWQLGRRLCQLWIACDVLCCTASIWNVTAIALDRY 140
Cdd:cd15132  21 TVLIIRRYKdmRTTTNLyLSSMAVSDLLI-LLCLPFDLYRLWKSRPWIFGEFLCRLYHYISEGCTYATILHITALSIERY 99
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 141 WSITRHLEY-TLRTRKRVSNVMILLtWALStVISLAPLLFGWGETYSEPSEECQVSREPSYT------------VFSTVG 207
Cdd:cd15132 100 LAICFPLRAkVLVTRRRVKCVIAAL-WAFA-LLSAGPFLFLVGVEQDNNIHPDDFSRECKHTpyavssgllgimIWVTTT 177
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 208 AFYLPLCVVLFVYWKIYRaakfrmgsrktnsvspvpEAVEVKNATQHPqmvftvrhatvtfqteGDTWREQKEQRAALMV 287
Cdd:cd15132 178 YFFLPMLCLSFLYGFIGR------------------KLWKSKNDLRGP----------------NAAARERSHRQTVRIL 223
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 84370345 288 GILIGVFVLCWFPFFVTELISPLCSWDVPAIWKSIF----LWLGYSNSFFNPLIYTAFNRSYSSA 348
Cdd:cd15132 224 AVVVLAFIICWLPFHIGRILFANTEDYRTMMFSQYFnivaMQLFYLSASINPILYNLISRKYRAA 288
7tmA_RNL3R cd14976
relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G ...
41-349 9.00e-10

relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This G protein-coupled receptor subfamily is composed of the relaxin-3 like peptide receptors, RNL3R1 and RNL3R2, and similar proteins. The relaxin-3 like peptide family includes relaxin-1, -2, -3, as well as insulin-like (INSL) peptides 3 to 6. RNL3/relaxin-3 and INSL5 are the endogenous ligands for RNL3R1 and RNL3R2, respectively. RNL3R1, also called GPCR135 or RXFP3, is predominantly expressed in the brain and is implicated in stress, anxiety, feeding, and metabolism. Insulin-like peptide 5 (INSL5), the endogenous ligand for RNL3R2 (also called GPCR142 or RXFP4), plays a role in fat and glucose metabolism. INSL5 is highly expressed in human rectal and colon tissues. Both RNL3R1 and RNL3R2 signal through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation. RNL3R1 is shown to activate Erk1/2 signaling pathway.


Pssm-ID: 320107 [Multi-domain]  Cd Length: 290  Bit Score: 59.05  E-value: 9.00e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  41 VLVLTLLGFLAAATFTWNLLVLATILKVRTFHRVP--HNLVASMAISDvLVAVLVMPLSLVHELSGRRWQLGRRLCQLWI 118
Cdd:cd14976   1 NLVSVVYMVVFTVGLLGNLLVLYLLKSNKKLRQQSesNKFVFNLALTD-LIFVLTLPFWAVEYALDFVWPFGTAMCKVVR 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 119 ACDVLCCTASIWNVTAIALDRYWSITRHLEYTLRTRKRVSNVMILLTWALSTVISLAPLLFGwGETYSEPSEECQVSREP 198
Cdd:cd14976  80 YVTKLNMYSSIFFLTALSVTRYIAVARALKHGWIRKAFGAFATTIAIWAAAALAAIPEAIFS-TDTWSSVNHTLCLLRFP 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 199 S-------------YTVFSTVGAFYLPLCVVLFVYWKIYRAAKFRMGSRKtnsvspvpeavevknatqhpqmvftvrhat 265
Cdd:cd14976 159 KnssvtrwynwlgmYQLQKVVLGFFLPLGIITLSYLLLLRFLQRKRGGSK------------------------------ 208
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 266 vtfqtegdtwreQKEQRAALMVGILIGVFVLCWFPFFVTELISPLCSWDVPAIWKSIFL----------WLGYSNSFFNP 335
Cdd:cd14976 209 ------------RRKSRVTKSVFIVVLSFFICWLPNQALSLWSALIKFDDVPFSDAFFAfqtyafpvaiCLAHSNSCLNP 276
                       330
                ....*....|....
gi 84370345 336 LIYTAFNRSYSSAF 349
Cdd:cd14976 277 VLYCLVRREFRDAL 290
7tmA_LPAR cd15101
lysophosphatidic acid receptor subfamily, member of the class A family of seven-transmembrane ...
41-349 1.60e-09

lysophosphatidic acid receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 341325 [Multi-domain]  Cd Length: 274  Bit Score: 57.91  E-value: 1.60e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  41 VLVLTLLGFLAAATFTWNLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSGRRWQLGRRLCQLWIAC 120
Cdd:cd15101   1 VLVMGLGITVCIFIMLANLLVIAAIYKNRRFHFPIYYLLANLAAADFFAGLAYFFLMFNTGPNTRRLTVSTWFLRQGLLD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 121 DVLccTASIWNVTAIALDRYWSITRHLEYTLRTRKRVSnVMILLTWALSTVISLAPLLfGWGETysepseeCQVSR---- 196
Cdd:cd15101  81 TSL--TASVANLLAIAVERHISVMRMQLHSRLSNRRVV-VLIVLVWTMAIVMGAIPSV-GWNCL-------CAIDAcsnm 149
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 197 ----EPSYTVFSTVGAFyLPLCVVLFVYWKIYRAAKfrmgsRKTNSVSPvpeavevknatqhpqmvftvrhatvtfQTEG 272
Cdd:cd15101 150 aplySRSYLVFWAISNL-VTFLVMVVVYARIFVYVR-----RRTNRMSP---------------------------HTSG 196
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 84370345 273 DTWREQKEQRAALMVGILIGVFVLCWFPFFVTELISPLC--SWDVPAIwKSIFLWLGYSNSFFNPLIYTAFNRSYSSAF 349
Cdd:cd15101 197 SIRNRDTMMSLLKTVVIVLGAFVVCWTPGLVVLLLDGLCcrQCNVLAV-EKFFLLLAEFNSAVNPIIYSYRDKEMSGTF 274
7tmA_LTB4R cd14975
leukotriene B4 receptors, member of the class A family of seven-transmembrane G ...
41-261 1.86e-09

leukotriene B4 receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the G(q)-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320106 [Multi-domain]  Cd Length: 278  Bit Score: 57.88  E-value: 1.86e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  41 VLVLTLLGFLAAATFTWNLLVLATILKVRTFHRVPHNLVASMAISDVLVaVLVMPLsLVHELSGRRWQLGRRLCQlwiAC 120
Cdd:cd14975   1 VLGCTLLSLAFAIGLPGNSFVIWSILIKVKQRSVTMLLVLNLALADLAV-LLTLPV-WIYFLATGTWDFGLAACK---GC 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 121 DVLCCT---ASIWNVTAIALDRYWSITRHLEYTLRTRKRVSNVMILLTWALSTVisLAPLLFGWGETYSEPSEECQVSRE 197
Cdd:cd14975  76 VYVCAVsmyASVFLITLMSLERFLAVSRPFVSQGWRAKALAHKVLAIIWLLAVL--LATPVIAFRHVEETVENGMCKYRH 153
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 198 PS------YTVFSTVGAFYLPLCVVLFVYWKIYRAAKFRMGSRKTNSVSPVPEAVEVKNATQHPQMVFTV 261
Cdd:cd14975 154 YSdgqlvfHLLLETVVGFAVPFTAVVLCYSCLLRRLRRRRFRRRRRTGRLIASVVVAFAACWLPYHVGNL 223
7tmA_NPFFR2 cd15980
neuropeptide FF receptor 2, member of the class A family of seven-transmembrane G ...
58-349 4.08e-09

neuropeptide FF receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320646 [Multi-domain]  Cd Length: 299  Bit Score: 57.20  E-value: 4.08e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  58 NLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSGRrWQLGRRLCQLWIACDVLCCTASIWNVTAIAL 137
Cdd:cd15980  18 NGVVCFIVLRSKHMRTVTNLFILNLAISDLLVGIFCMPTTLLDNIIAG-WPFGSTVCKMSGMVQGISVSASVFTLVAIAV 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 138 DRYWSITRHLEYTLRTRKRVSNVMILLTWALSTVISLAPLLFGWGETYSEPSEECQVSREPSY------------TVFST 205
Cdd:cd15980  97 DRFRCIVYPFKQKLTISTAVVIIVIIWVLAIAIMCPSAVMLHVQEEKNYRVVLGSQNKTSPVYwcredwpnqemrKIYTT 176
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 206 V--GAFYL-PLCVVLFVYWKIyraakfrmgsrktnSVSPVPEAVEVKNATQHPQmvftvRHATvtfqtegdtwrEQKEQR 282
Cdd:cd15980 177 VlfANIYLaPLSLIVIMYARI--------------GITLFKTAMPHTGKHNQEQ-----RHVV-----------SRKKQK 226
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 84370345 283 AALMVGILIGVFVLCWFPFFVTELISPLCS-----WDVPAIWKSIFL-WLGYSNSFFNPLIYTAFNRSYSSAF 349
Cdd:cd15980 227 VIKMLLIVALLFILSWLPLWTLMMLSDYANlspnqLQIINIYIYPFAhWLAFFNSSVNPIIYGFFNENFRRGF 299
7tmA_GPR45 cd15403
G protein-coupled receptor 45, member of the class A family of seven-transmembrane G ...
41-338 4.16e-09

G protein-coupled receptor 45, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the human orphan receptor GPR45 and closely related proteins found in vertebrates. GPR45 is also called PSP24 in Xenopus and PSP24-alpha (or PSP24-1) in mammals. GPR45 shows the highest sequence homology with GPR63 (PSP24-beta, or PSP24-2). PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Mammalian PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320525 [Multi-domain]  Cd Length: 301  Bit Score: 57.17  E-value: 4.16e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  41 VLVLTLLGFLAAATFTWNLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSGRrWQLGRRLCQLWIAC 120
Cdd:cd15403   1 ILLAIVMILMIAIGFLGNAIVCLIVYQKPAMRSAINLLLATLAFSDIMLSLLCMPFTAVTIITVD-WHFGAHFCRISAML 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 121 DVLCCTASIWNVTAIALDRYWSITRHLEytlRTRKRVSNVMILLTWALSTVISLaPLLFGWgeTYSE-PSEECQ------ 193
Cdd:cd15403  80 YWFFVLEGVAILLIISVDRFLIIVQRQD---KLNPHRAKVMIAISWVLSFCISF-PSVVGW--TLVEvPARAPQcvlgyt 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 194 -VSREPSYTVFSTVGAFYLPLCVVLFVYWKIYRAAKfrmgsRKTNSVSPVPEAVEVKNATQHPQMVFTVRH---ATVTFQ 269
Cdd:cd15403 154 eSPADRVYAVLLVVAVFFVPFSIMLYSYLCILNTVR-----RNAVRIHNHADSLCLSQVSKLGLMGLQRPHqmnVDMSFK 228
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 84370345 270 TegdtwreqkeqRAALMVGILIGVFVLCWFPFFVTELISPL-----CSWDVPAIwKSIFLWLGYSNSFFNPLIY 338
Cdd:cd15403 229 T-----------RAFTTILILFVGFSLCWLPHTVFSLLSVFsrrfyYSSSFYPI-STCVLWLSYLKSVFNPVIY 290
7tmA_NMU-R2 cd15357
neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G ...
58-349 4.22e-09

neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320479 [Multi-domain]  Cd Length: 293  Bit Score: 56.79  E-value: 4.22e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  58 NLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSGRRWQLGRRLCQLWIACDVLCCTASIWNVTAIAL 137
Cdd:cd15357  18 NLLVCLVILKHQNMKTPTNYYLFSLAVSDLLVLLFGMPLEVYEMWSNYPFLFGPVGCYFKTALFETVCFASILSVTTVSV 97
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 138 DRYWSITRHLEYTLR-TRKRVSNVMILLtWALSTVISLA-------PLLFGWGETYSEPSEECQVSREP---SYTVFSTV 206
Cdd:cd15357  98 ERYVAILHPFRAKLNsTRERALKIIVVL-WVLSVLFSIPntsihgiKLQYFPNGTLIPDSATCTVVKPLwiyNLIIQITS 176
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 207 GAFY-LPLCVVLFVYwkiyraakFRMGSRKTNSVSpvPEAVEVKNATQHPQmvftvrhatvtfqtegdtwreqkEQRAAL 285
Cdd:cd15357 177 LLFYvLPMGVISVLY--------YLMGLKLRGDKS--LEADEMNVNIQRPS-----------------------RKSVTK 223
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 84370345 286 MVGILIGVFVLCWFPF--------FVTELISPLCS-WDVPAIWKSIFLWLgysNSFFNPLIYTAFNRSYSSAF 349
Cdd:cd15357 224 MLFVLVLVFAICWAPFhvdrlffsFVVEWTEPLANvFNLIHVVSGVFFYL---SSAVNPIIYNLLSRRFRTAF 293
7tmA_Adenosine_R_A1 cd15071
adenosine receptor subtype A1, member of the class A family of seven-transmembrane G ...
58-349 4.26e-09

adenosine receptor subtype A1, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine A1 receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand. The A1 receptor has primarily inhibitory function on the tissues in which it is located. The A1 receptor slows metabolic activity in the brain and has a strong anti-adrenergic effects in the heart. Thus, it antagonizes beta1-adrenergic receptor-induced stimulation and thereby reduces cardiac contractility. The A1 receptor preferentially couples to G proteins of the G(i/o) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels.


Pssm-ID: 341323 [Multi-domain]  Cd Length: 290  Bit Score: 56.78  E-value: 4.26e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  58 NLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSgrrWQLGRRLCqLWIACDVLCCT-ASIWNVTAIA 136
Cdd:cd15071  18 NVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAIIINIG---PQTEFYSC-LMVACPVLILTqSSILALLAIA 93
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 137 LDRYWSITRHLEYTLRTRKRVSNVMILLTWALSTVISLAPlLFGWGE------------TYSEPSEECQVSREPS--YTV 202
Cdd:cd15071  94 VDRYLRVKIPTRYKSVVTPRRAAVAIAGCWILSFLVGLTP-MFGWNNlnaverawaansSMGELVIKCQFETVISmeYMV 172
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 203 FSTVGAFYL-PLCVVLFVYWKIyraakFRMGSRKTNSvspvpeavEVKNATQHPQMVFtvrhatvtfqtegdtwreQKEQ 281
Cdd:cd15071 173 YFNFFVWVLpPLLLMLLIYLEV-----FYLIRKQLNK--------KVSSSSSDPQKYY------------------GKEL 221
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 84370345 282 RAALMVGILIGVFVLCWFPFFVTELISPLC-SWDVPAIWKSIFLWLGYSNSFFNPLIYTAFNRSYSSAF 349
Cdd:cd15071 222 KIAKSLALILFLFALSWLPLHILNCITLFCpSCKKPMILTYIAIFLTHGNSAMNPIVYAFRIKKFRTTF 290
7tmA_LPAR2_Edg4 cd15342
lysophosphatidic acid receptor subtype 2 (LPAR2 or LPA2), also called Endothelial ...
58-349 6.19e-09

lysophosphatidic acid receptor subtype 2 (LPAR2 or LPA2), also called Endothelial differentiation gene 4 (Edg4), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320464 [Multi-domain]  Cd Length: 274  Bit Score: 56.34  E-value: 6.19e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  58 NLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSL-----VHELSGRRWQLGRRLCQLWIacdvlccTASIWNV 132
Cdd:cd15342  18 NLLVIAAIFINRRFHYPIYYLLGNLAAADLFAGVAYLFLMFhtgpwTAKLSLYQWFLRQGLLDTSL-------TASVANL 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 133 TAIALDRYWSITRHLEYTLRTRKRVSnVMILLTWALSTVISLAPlLFGWgetysepSEECQVSR--------EPSYTVFS 204
Cdd:cd15342  91 LAIAVERHQTIFTMQLHSKMSNQRVV-ILIFGIWMVALILGLIP-AMGW-------NCLCDLKRcstmaplySRSYLVFW 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 205 TVGAFyLPLCVVLFVYWKIYRAAKFRMGSRKTNSVSPvpeavevknatqhpqmvftVRHatvtfqtegdtwreqKEQRAA 284
Cdd:cd15342 162 ALSNL-LTFLIMVAVYTRIFIYVRRKSQRMSEHHSSH-------------------PRY---------------RETVLG 206
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 84370345 285 LM--VGILIGVFVLCWFPFFVTELISPLC--SWDVPAIWKsIFLWLGYSNSFFNPLIYTAFNRSYSSAF 349
Cdd:cd15342 207 LMktVVIILGAFVVCWTPGQVVLLLDGLGceSCNVLAYEK-YFLLLAEINSLVNPIVYSYRDKEMRKTF 274
7tmA_GPR19 cd15008
G protein-coupled receptor 19, member of the class A family of seven-transmembrane G ...
58-345 6.31e-09

G protein-coupled receptor 19, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 19 is an orphan receptor that is expressed predominantly in neuronal cells during mouse embryogenesis. Its mRNA is found frequently over-expressed in patients with small cell lung cancer. GPR19 shares a significant amino acid sequence identity with the D2 dopamine and neuropeptide Y families of receptors. Human GPR19 gene, intronless in the coding region, also has a distribution in brain overlapping that of the D2 dopamine receptor gene, and is located on chromosome 12. GPR19 is a member of the class A family of GPCRs, which represents a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320137 [Multi-domain]  Cd Length: 275  Bit Score: 56.38  E-value: 6.31e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  58 NLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSGrRWQLGRRLCQLWIACDVLCCTASIWNVTAIAL 137
Cdd:cd15008  17 NSLVCLVIHRSRRTQSTTNYFVVSMACADLLLSVASAPFVLLQFTSG-RWTLGSAMCKLVRYFQYLTPGVQIYVLLSICV 95
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 138 DRYWSITRHLEYTLRTRKrvSNVMILLTWALSTVIsLAPLLFGWGetySEPSEECQVSREPS-----YTVFSTVGAFYLP 212
Cdd:cd15008  96 DRFYTIVYPLSFKVSREK--AKKMIAASWLFDAAF-VSPALFFYG---SNWGPHCNFFLPDSwdgaaYAIIHLLVGFLVP 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 213 LCVVLFVYWK----IYRAAKFRMGSRKTNSVSPVPEAVEVKnatqhpqmvftvrhatvtfqtegdtwreqkeqraalMVG 288
Cdd:cd15008 170 SILIILFYQKvikyIWRIGTDGRTVRRTMNIVPRTKVKTIK------------------------------------MFL 213
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 84370345 289 ILIGVFVLCWFPFFVTELISPLCS-WDVPAIWKSIFLWLGYSNSFFNPLIYTAFNRSY 345
Cdd:cd15008 214 MLNSMFLLSWLPFYVVQLWHPRESdYRQSSLVFLAVTWISFSSSASKPTLYSVYNANF 271
7tmA_GPR150 cd15198
G protein-coupled receptor 150, member of the class A family of seven-transmembrane G ...
44-342 6.86e-09

G protein-coupled receptor 150, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors. Its endogenous ligand is not known. These receptors share a significant amino acid sequence similarity, suggesting that they have a common evolutionary origin.


Pssm-ID: 320326 [Multi-domain]  Cd Length: 299  Bit Score: 56.35  E-value: 6.86e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  44 LTLLGFLAAATFTWNLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSGRRWQLGRRLCQLWIACDVL 123
Cdd:cd15198   4 LIFLGVILVAGVAGNTTVLCWLCGGRRRKSRMNFLLLQLALADLLVIGGTALSQIIWELLGDRWMAGDVACRLLKLLQAS 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 124 CCTASIWNVTAIALDRYWSITRHLEYTLRTRKrvsnvMILLTWALSTVISLAPL-LFGWGETYSEPSEECQVSREPS--- 199
Cdd:cd15198  84 ARGASANLVVLLALDRHQAIRAPLGQPLRAWK-----LAALGWLLALLLALPQAyVFRVDFPDDPASAWPGHTLCRGifa 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 200 ---------YTVFSTVGAFYLPLCVVLFVYWKIYRAAKFRmgsrktNSVSPVPEAVEVKNATQHpqmvftvrhatvtFQT 270
Cdd:cd15198 159 plprwhlqvYATYEAVVGFVAPVVILGVCYGRLLLKWWER------ANQAPGAKKPWKKPSKSH-------------LRA 219
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 84370345 271 EGDTWREQKEQRAALMVGILIGVFVLCWFPFFVTELISPLCSWD-VPAIWKSIFLWLGYSNSFFNPLIYTAFN 342
Cdd:cd15198 220 TAPSALPRAKVKTLKMTLVIALLFVGCSLPYFIAELAAAFGSGDwEPEKVAAALGVMAVANSATNPFVFLFFN 292
7tmA_Trissin_R cd15012
trissin receptor and related proteins, member of the class A family of seven-transmembrane G ...
42-223 7.23e-09

trissin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the Drosophila melanogaster trissin receptor and closely related invertebrate proteins which are a member of the class A family of seven-transmembrane G-protein coupled receptors. The cysteine-rich trissin has been shown to be an endogenous ligand for the orphan CG34381 in Drosophila melanogaster. Trissin is a peptide composed of 28 amino acids with three intrachain disulfide bonds with no significant structural similarities to known endogenous peptides. Cysteine-rich peptides are known to have antimicrobial or toxicant activities, although frequently their mechanism of action is poorly understood. Since the expression of trissin and its receptor is reported to predominantly localize to the brain and thoracicoabdominal ganglion, trissin is predicted to behave as a neuropeptide. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320140 [Multi-domain]  Cd Length: 277  Bit Score: 55.91  E-value: 7.23e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  42 LVLTLLGFLAAATFTWNLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELsGRRWQLGRRLCQLWIACD 121
Cdd:cd15012   1 IFIILYTLVFCCCFFGNLLVILVVTSHRRMRTITNFFLANLAVADLCVGIFCVLQNLSIYL-IPSWPFGEVLCRMYQFVH 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 122 VLCCTASIWNVTAIALDRYWSITRHLEYTLRTRKRVSNVMILLTWALSTVISLAPLLFGWGETYSEPSEECQVSRE---- 197
Cdd:cd15012  80 SLSYTASIGILVVISVERYIAILHPLRCKQLLTAARLRVTIVTVWLTSAVYNTPYFVFSQTVEILVTQDGQEEEICvldr 159
                       170       180       190
                ....*....|....*....|....*....|.
gi 84370345 198 -----PSYTVFSTVGAFYLPLCVVLFVYWKI 223
Cdd:cd15012 160 emfnsKLYDTINFIVWYLIPLLIMTVLYSKI 190
7tmA_Retinal_GPR cd15072
retinal G protein coupled receptor, member of the class A family of seven-transmembrane G ...
42-242 7.36e-09

retinal G protein coupled receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the retinal G-protein coupled receptor (RGR) found exclusively in retinal pigment epithelium (RPE) and Muller cells. RGR is a member of the class A rhodopsin-like receptor family. As with other opsins, RGR binds all-trans retinal and contains a conserved lysine reside on the seventh helix. RGR functions as a photoisomerase to catalyze the conversion of all-trans-retinal to 11-cis-retinal. Two mutations in RGR gene are found in patients with retinitis pigmentosa, indicating that RGR is essential to the visual process.


Pssm-ID: 320200 [Multi-domain]  Cd Length: 260  Bit Score: 55.83  E-value: 7.36e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  42 LVLTLLGFlaaatfTWNLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLvmplSLVHELSG--RRWQLGRRLCQLWIA 119
Cdd:cd15072   8 LVEALVGF------SLNGLTILSFCKTRELRTPSNLLVLSLAVADMGISLN----ALVAASSSllRRWPYGSEGCQAHGF 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 120 CDVLCCTASIWNVTAIALDRYwsitrhLEYTLRTRKRVSNV--MILLTWALSTVISLAPLLfGWGETYSEPSEEC----- 192
Cdd:cd15072  78 QGFFTALASICSSAAIAWDRY------HHYCTRSKLQWSTAisLVLFVWLFSAFWAAMPLL-GWGEYDYEPLGTCctldy 150
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|..
gi 84370345 193 QVSREP--SYTVFSTVGAFYLPLCVVLFVYWKIYRAAKfRMGSRKTNSVSPV 242
Cdd:cd15072 151 SKGDRNyvSYLFTMAFFNFILPLFILLTSYSSIEQKLK-KEGHLRFNTGLPL 201
7tmA_GPR25 cd15193
G protein-coupled receptor 25, member of the class A family of seven-transmembrane G ...
55-225 7.96e-09

G protein-coupled receptor 25, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR25 is an orphan G-protein coupled receptor that shares strong sequence homology to GPR15 and the angiotensin II receptors. These closely related receptors form a group within the class A G-protein coupled receptors (GPCRs). GPR15 controls homing of T cells, especially FOXP3(+) regulatory T cells, to the large intestine mucosa and thereby mediates local immune homeostasis. Moreover, GRP15-deficient mice were shown to be prone to develop more severe large intestine inflammation. Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors.


Pssm-ID: 320321 [Multi-domain]  Cd Length: 279  Bit Score: 55.91  E-value: 7.96e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  55 FTWNLLVLATILKVRTFHRVPHNLVASMAISDvLVAVLVMPLSLVHELSGRRWQLGRRLCQLWIACDVLCCTASIWNVTA 134
Cdd:cd15193  15 LLGNLFVIALMSKRSTTKRLVDTFVLNLAVAD-LVFVLTLPFWAASTALGGQWLFGEGLCKLSSFIIAVNRCSSILFLTG 93
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 135 IALDRYWSITRHLEYT-LRTRkRVSNVMILLTWALSTVISLAPLLFGWGETYSEPSEECQVSREPSYTVFSTVGAFYLPL 213
Cdd:cd15193  94 MSVDRYLAVVKLLDSRpLRTR-RCALITCCIIWAVSLVLGIPSLVYRNLINESVCVEDSSSRFFQGISLATLFLTFVLPL 172
                       170
                ....*....|..
gi 84370345 214 CVVLFVYWKIYR 225
Cdd:cd15193 173 IVILFCYCSILV 184
7tmA_Gal1_R cd15098
galanin receptor subtype 1, member of the class A family of seven-transmembrane G ...
41-349 8.51e-09

galanin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320226 [Multi-domain]  Cd Length: 282  Bit Score: 55.89  E-value: 8.51e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  41 VLVLTLLGFLAAATFTWNLLVLATILKVRTFHRV-PHNL-VASMAISDVLVAVLVMPL-SLVHELSGrrWQLGRRLCQLW 117
Cdd:cd15098   1 VIVPVVFGLIFCLGVLGNSLVITVLARVKPGKRRsTTNVfILNLSIADLFFLLFCVPFqATIYSLPE--WVFGAFMCKFV 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 118 IACDVLCCTASIWNVTAIALDRYWSITRHL-EYTLRTRkRVSNVMILLTWALSTVISLAPLLF--------GWGETYSEP 188
Cdd:cd15098  79 HYFFTVSMLVSIFTLVAMSVDRYIAVVHSRtSSSLRTR-RNALLGVLVIWVLSLAMASPVAVHqdlvhhwtASNQTFCWE 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 189 SEECQVSRePSYTVFSTVGAFYLPLCVVLFVYWKIYRA--AKFRMGSRKTnsvspvpeavevknatqhpqmvftvrhatv 266
Cdd:cd15098 158 NWPEKQQK-PVYVVCTFVFGYLLPLLLITFCYAKVLNHlhKKLKNMSKKS------------------------------ 206
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 267 tfqtegdtwrEQKEQRAALMVGILIGVFVLCWFPFFVTELISPLCSW---DVPAIWKSIFLWLGYSNSFFNPLIYTAFNR 343
Cdd:cd15098 207 ----------ERSKKKTAQTVLVVVVVFGISWLPHHIIHLWVEFGDFpltQASFVLRITAHCLAYANSCVNPIIYAFLSE 276

                ....*.
gi 84370345 344 SYSSAF 349
Cdd:cd15098 277 NFRKAY 282
7tmA_LTB4R1 cd15121
leukotriene B4 receptor subtype 1 (LTB4R1 or BLT1), member of the class A family of ...
42-237 8.83e-09

leukotriene B4 receptor subtype 1 (LTB4R1 or BLT1), member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the Gq-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320249 [Multi-domain]  Cd Length: 278  Bit Score: 55.98  E-value: 8.83e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  42 LVLTLLGFLAAATFTWNLLVLATILKVRTFHRVPHNLVASMAISDVLVaVLVMPLSLvHELSGRRWQLGRRLCQLwiaCD 121
Cdd:cd15121   2 LGIAILSLAFILGFPGNLFVVWSVLCRMKKRSVTCILVLNLALADAAV-LLTAPFFL-HFLSGGGWEFGSVVCKL---CH 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 122 VLCCT---ASIWNVTAIALDRYWSITR-HLEYTLRTrKRVSNVMILLTWALSTVISLaPLLFGWGETYSEPSEECQVSRE 197
Cdd:cd15121  77 YVCGVsmyASIFLITLMSMDRCLAVAKpFLSQKMRT-KRSVRALLLAIWIVAFLLSL-PMPFYRTVLKKNINMKLCIPYH 154
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*....
gi 84370345 198 PS------YTVFSTVGAFYLPLCVVLFVYWKI---YRAAKFRMgSRKTN 237
Cdd:cd15121 155 PSvgheafQYLFETITGFLLPFTAIVTCYSTIgrrLRSARFRR-KRRTN 202
7tmA_KiSS1R cd15095
KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of ...
43-349 1.01e-08

KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled KiSS1-derived peptide receptor (GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (previously known as metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. The KiSS1 receptor is coupled to G proteins of the G(q/11) family, which lead to activation of phospholipase C and increase of intracellular calcium. This signaling cascade plays an important role in reproduction by regulating the secretion of gonadotropin-releasing hormone.


Pssm-ID: 320223 [Multi-domain]  Cd Length: 288  Bit Score: 55.75  E-value: 1.01e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  43 VLTLLGFLAaatftwNLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLS-LVHELSGrrWQLGRRLCQLWIACD 121
Cdd:cd15095   9 IIFLVGLAG------NSLVIYVVSRHREMRTVTNYYIVNLAVTDLAFLVCCVPFTaALYATPS--WVFGDFMCKFVNYMM 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 122 VLCCTASIWNVTAIALDRYWSITRHLEyTLRTR-KRVSNVMILLTWALSTVISLaPLLFGWGETYSEPSEECQVSRE--- 197
Cdd:cd15095  81 QVTVQATCLTLTALSVDRYYAIVHPIR-SLRFRtPRVAVVVSACIWIVSFLLSI-PVAIYYRLEEGYWYGPQTYCREvwp 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 198 -----PSYTVFSTVGAFYLPLCVVLFVYWKIYRaakfRMGSRKtnsvspvpeaveVKNATQHPQMvfTVRHAtvtfqteg 272
Cdd:cd15095 159 skafqKAYMIYTVLLTYVIPLAIIAVCYGLILR----RLWRRS------------VDGNNQSEQL--SERAL-------- 212
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 273 dtwreQKEQRAALMVGILIGVFVLCWFPFFVTEL-----ISPLCSWDVPAiWKSIFLWLGYSNSFFNPLIYTAFNRSYSS 347
Cdd:cd15095 213 -----RQKRKVTRMVIVVVVLFAICWLPNHVLNLwqrfdPNFPETYATYA-LKIAALCLSYANSAVNPFVYAFMGENFRK 286

                ..
gi 84370345 348 AF 349
Cdd:cd15095 287 YF 288
7tmA_Kappa_opioid_R cd15091
opioid receptor subtype kappa, member of the class A family of seven-transmembrane G ...
58-349 1.04e-08

opioid receptor subtype kappa, member of the class A family of seven-transmembrane G protein-coupled receptors; The kappa-opioid receptor binds the opioid peptide dynorphin as the primary endogenous ligand. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320219 [Multi-domain]  Cd Length: 282  Bit Score: 55.73  E-value: 1.04e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  58 NLLVLATILKVRTFHRVPHNLVASMAISDVLVAVlVMPLSLVHELSGRrWQLGRRLCQLWIACDVLCCTASIWNVTAIAL 137
Cdd:cd15091  18 NSLVMFVIIRYTKMKTATNIYIFNLALADALVTT-TMPFQSTVYLMNS-WPFGDVLCKIVISIDYYNMFTSIFTLTMMSV 95
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 138 DRYWSI---TRHLEYTLRTRKRVSNVMIlltWALSTVISLAPLLFGWGETY-SEPSEECQVS-REPSYTVFSTVgafyLP 212
Cdd:cd15091  96 DRYIAVchpVKALDFRTPLKAKIINICI---WLLSSSVGISAIVLGGTKVReDVDSTECSLQfPDDDYSWWDTF----MK 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 213 LCVVLFVYwkiyraakfrmgsrktnsVSPVpeaveVKNATQHPQMVFTVRHATVtfqTEGDTWREQKEQRAALMVGILIG 292
Cdd:cd15091 169 ICVFIFAF------------------VIPV-----LIIIVCYTLMILRLKSVRL---LSGSREKDRNLRRITRLVLVVVA 222
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 293 VFVLCWFPFFVTELISPLCSWDVPAIWKSIFLW---LGYSNSFFNPLIYTAFNRSYSSAF 349
Cdd:cd15091 223 VFVVCWTPIHIFILVEALGSVSHSTAAVSSYYFciaLGYTNSSLNPILYAFLDENFKRCF 282
7tmA_GPR17 cd15161
G protein-coupled receptor 17, member of the class A family of seven-transmembrane G ...
82-234 1.08e-08

G protein-coupled receptor 17, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR17 is a Forkhead box protein O1 (FOXO1) target and abundantly expressed in agouti-related peptide (AGRP) neurons. FOXO1 is a transcription factor that plays key roles in regulation of gluconeogenesis and glycogenolysis by insulin signaling. For instance, food intake and body weight increase when hypothalamic FOXO1 is activated, whereas they both decrease when FOXO1 is inhibited. However, a recent study has been reported that GPR17 deficiency in mice did not affect food intake or glucose homeostasis. Thus, GPR17 may not play a role in the control of food intake, body weight, or glycemic control. GPR17 is phylogenetically closely related to purinergic P2Y and cysteinyl-leukotriene receptors.


Pssm-ID: 320289 [Multi-domain]  Cd Length: 277  Bit Score: 55.48  E-value: 1.08e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  82 MAISDvLVAVLVMPLSLVHELSGRRWQLGRRLCQLWIACDVLCCTASIWNVTAIALDRYWSITrHLEYTLRTRK-RVSNV 160
Cdd:cd15161  42 LAVAD-LSYVLILPMRLVYHLSGNHWPFGEVPCRLAGFLFYLNMYASLYFLACISVDRFLAIV-HPVKSMKIRKpLYAHV 119
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 84370345 161 MILLTWALSTViSLAPLLFGWGETYSEPSEEC-QVSRE--PSYTVFSTVGAFYLPLCVVLFVYWKIYRaaKFRMGSR 234
Cdd:cd15161 120 VCGFLWVIVTV-AMAPLLVSPQTVEVNNTTVClQLYREkaSRGALVSLAVAFTIPFVTTVTCYLLIIR--SLRTGKR 193
7tmA_capaR cd15134
neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of ...
58-349 1.78e-08

neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; CapaR is a G-protein coupled receptor for the Drosophila melanogaster capa neuropeptides (Drm-capa-1 and -2), which act on the Malpighian tubules to increase fluid transport. The capa peptides are evolutionarily related to vertebrate Neuromedin U neuropeptide and contain a C-terminal FPRXamide motif. CapaR regulates fluid homeostasis through its ligands, thereby acts as a desiccation stress-responsive receptor. CapaR undergoes desensitization, with internalization mediated by beta-arrestin-2.


Pssm-ID: 320262 [Multi-domain]  Cd Length: 298  Bit Score: 55.03  E-value: 1.78e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  58 NLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSGRRWQLGRRLCQLWIACDVLCCTASIWNVTAIAL 137
Cdd:cd15134  18 NLCTCIVIARNRSMHTATNYYLFSLAVSDLLLLILGLPFELYTIWQQYPWVFGEVFCKLRAFLSEMSSYASVLTITAFSV 97
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 138 DRYWSITRHL-EYTLRTRKRvSNVMILLTWALSTVISL----------APLLFGWGETYSEpSEECQVSRE-PSYTV--- 202
Cdd:cd15134  98 ERYLAICHPLrSHTMSKLSR-AIRIIIAIWIIAFVCALpfaiqtrivyLEYPPTSGEALEE-SAFCAMLNEiPPITPvfq 175
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 203 FSTVGAFYLPLCVVLFVYWKIyraakfrmgsrktnsvspvpeAVEVKNATQHPQMVFTVRhatvtfqtegDTWREQKEQR 282
Cdd:cd15134 176 LSTFLFFIIPMIAIIVLYVLI---------------------GLQLRRSTLLRRGQRSVS----------GGRRSSQSRR 224
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 84370345 283 AAL-MVGILIGVFVLCWFPFFVTELISPLCSWDVPAIWKsIFLWLGYSNSFF-------NPLIYTAFNRSYSSAF 349
Cdd:cd15134 225 TVLrMLVAVVVAFFICWAPFHAQRLLTVYAKNMTPPYLF-INRILFYISGVLyyvsstvNPILYNVMSAKYRQAF 298
7tmA_MCR cd15103
melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
58-338 2.26e-08

melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320231 [Multi-domain]  Cd Length: 270  Bit Score: 54.42  E-value: 2.26e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  58 NLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHEL--SGRRWQLGRRLCQLWIACDVLCCT---ASIWNV 132
Cdd:cd15103  18 NILVILAIAKNKNLHSPMYFFICSLAVADMLVSVSNALETIVIILlnNGYLVPRDSFEQHIDNVIDSMICSsllASICSL 97
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 133 TAIALDRYWSITRHLEYTLRTRKRVSNVMILLTWALSTVISLAPLLFGwgetysepseecqvsrEPSYTVFSTVGAFYLP 212
Cdd:cd15103  98 LAIAVDRYITIFYALRYHSIMTVRRAGVIITAIWVFCTVCGILFIIYS----------------DSVPVIICLISMFFAM 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 213 LCVVLFVYWKIYRAAkfRMGSRKtnsVSPVPEAVEVKnatQHPQMvftvrhatvtfqtegdtwreqkeqRAALMVGILIG 292
Cdd:cd15103 162 LVLMASLYVHMFLLA--RSHVKK---IAALPGQRSTR---QRANM------------------------KGAVTLTILLG 209
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 84370345 293 VFVLCWFPFFVTELISPLCSWDVPAIWK----SIFLWLGYSNSFFNPLIY 338
Cdd:cd15103 210 VFIFCWAPFFLHLTLMISCPSNPYCACYmshfNVYLILIMCNSVIDPLIY 259
7tmA_LPAR1_Edg2 cd15344
lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial ...
58-349 2.57e-08

lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial differentiation gene 2 (Edg2), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 341348 [Multi-domain]  Cd Length: 273  Bit Score: 54.26  E-value: 2.57e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  58 NLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSGRRWQLGRRLCQLWIACDVLccTASIWNVTAIAL 137
Cdd:cd15344  18 NLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVSTWLLRQGLIDTSL--TASVANLLAIAI 95
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 138 DRYWSITRHLEYTLRTRKRVSnVMILLTWALSTVISLAPLLfGWgetysepseECQVSREPSYTVFSTVGAFYLplcvvl 217
Cdd:cd15344  96 ERHITVFRMQLHTRMSNRRVV-VVIVVIWTMAIVMGAIPSV-GW---------NCICDIENCSNMAPLYSDSYL------ 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 218 fVYWKIYRAAKFrmgsrktnsvspvpeaveVKNATQHPQMVFTVRHATVTFQTEGDTWREQKEQRAALM--VGILIGVFV 295
Cdd:cd15344 159 -VFWAIFNLVTF------------------VVMVVLYAHIFGYVRQRTMRMSRHSSGPRRNRDTMMSLLktVVIVLGAFI 219
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 84370345 296 LCWFPFFVTELISPLCSWDVPAIWKSIFLWLGYSNSFFNPLIYTAFNRSYSSAF 349
Cdd:cd15344 220 ICWTPGLVLLLLDVCCPQCDVLAYEKFFLLLAEFNSAMNPIIYSYRDKEMSATF 273
7tmA_MC2R_ACTH_R cd15350
melanocortin receptor subtype 2, also called adrenocorticotropic hormone receptor, member of ...
50-338 2.80e-08

melanocortin receptor subtype 2, also called adrenocorticotropic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320472 [Multi-domain]  Cd Length: 270  Bit Score: 54.40  E-value: 2.80e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  50 LAAATFTWNLLVLATILKVRTFHRVPHNLVASMAISDVLVAV------LVMPLSLVHELSgRRWQLGRRLCQLWIACDVL 123
Cdd:cd15350  10 IAAVGLLENLLVLVAVIKNKNLHSPMYFFICSLAVSDMLGSLyktlenILIILADMGYLN-RRGPFETKLDDIMDSLFCL 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 124 CCTASIWNVTAIALDRYWSITRHLEY-TLRTRKRVSnVMILLTWALSTVISLAPLLFgwgetysepseecqvSREPSYTV 202
Cdd:cd15350  89 SLLGSIFSILAIAADRYITIFHALRYhNIMTMRRTL-VILAIIWTFCGGSGILMILF---------------FHFVATVI 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 203 FSTVgAFYLPLCVVLFVYWKIYRAAkfRMGSRKTNSVSPvpeavevkNATQHPQmvftvrhatvtfqtegdtwreqKEQR 282
Cdd:cd15350 153 CFTV-LFFLMLVLILCLYVHMFLLA--RSHARKIASLPN--------HHAQHQR----------------------SNMR 199
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 283 AALMVGILIGVFVLCWFPFFVTELISPLCSWD-VPAIWKSIF---LWLGYSNSFFNPLIY 338
Cdd:cd15350 200 GAITLTILLGVFVCCWAPFVLHLLLMMFCPMNpYCACYRSLFqvnGTLIMSHAVIDPAIY 259
7tmA_NMU-R1 cd15358
neuromedin U receptor subtype 1, member of the class A family of seven-transmembrane G ...
58-349 3.90e-08

neuromedin U receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320480 [Multi-domain]  Cd Length: 305  Bit Score: 54.00  E-value: 3.90e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  58 NLLVLATILKVRTFhRVPHNL-VASMAISDVLVAVLVMPLSLVHELSGRRWQLGRRLCQLWIACDVLCCTASIWNVTAIA 136
Cdd:cd15358  18 NGLTCIVILRHKVM-RTPTNYyLFSLAVSDLLVLLLGMPLELYEMWSNYPFLLGAGGCYFKTLLFETVCFASILNVTALS 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 137 LDRYWSITRHLEYTLRTRKRVSNVMILLTWALSTVISLAPL-------LFGWGETYSEPSEECQVSRePSYTV-----FS 204
Cdd:cd15358  97 VERYIAVVHPLKAKYVVTRTHAKRVIGAVWVVSILCSIPNTslhgifqLTVPCRGPVPDSATCMLVK-PRWMYnliiqIT 175
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 205 TVGAFYLPLCVVLFVYWKI-YRAAKFRMgsrktnsvspvPEAVEVKNatqhpqmvftvRHATVTFQTEGDTWREQKEQRA 283
Cdd:cd15358 176 TLLFFFLPMGTISVLYLLIgLQLKREKM-----------LLVLEAKG-----------SKAGDSYQHRRIQQEKRRRRQV 233
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 84370345 284 ALMVGILIGVFVLCWFPFFVTELI-SPLCSWDVPA--------IWKSIFLWLGysnSFFNPLIYTAFNRSYSSAF 349
Cdd:cd15358 234 TKMLFVLVVVFGICWAPFHTDRLMwSFISQWTGELhlafqyvhIISGVFFYLS---SAANPVLYNLMSTRFREMF 305
7tmA_NPY4R cd15397
neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G ...
41-345 4.05e-08

neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety.


Pssm-ID: 320519 [Multi-domain]  Cd Length: 293  Bit Score: 53.97  E-value: 4.05e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  41 VLVLTLLGflaaatftwNLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSGrRWQLGRRLCQLWIAC 120
Cdd:cd15397  10 VMAVGLLG---------NICLICVIARQKEKTNVTNILIANLSFSDILVCLVCLPFTVVYTLMD-YWIFGEVLCKMTPFI 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 121 DVLCCTASIWNVTAIALDRYWSITRHLEYtlRTRKRVSNVMILLTWALSTVISLAPLLFGWGET--------YSEPSEEC 192
Cdd:cd15397  80 QCMSVTVSILSLVLIALERHQLIINPTGW--KPSVSQAYLAVVVIWMLACFISLPFLAFHILTDepyknlshFFAPLADK 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 193 QVSRE--PS------YTVFSTVGAFYLPLCVVLFVYWKIYRaakfRMGSRKtnsvspvpeavevknatqhpqmvftvrha 264
Cdd:cd15397 158 AVCTEswPSehhklaYTTWLLLFQYCLPLLFILVCYLRIYL----RLRRRK----------------------------- 204
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 265 TVTFQTEGDTWREQKEQRAALMVGILIGVFVLCWFPFFVTELISplcSWDVPAIWKS----IFL---WLGYSNSFFNPLI 337
Cdd:cd15397 205 DMLERRGEYNRRAGHSKRINVMLVSLVAAFALCWLPLNVFNAIA---DWNHEAIPHCqhnlIFSlchLAAMASTCVNPII 281

                ....*...
gi 84370345 338 YTAFNRSY 345
Cdd:cd15397 282 YGFLNSNF 289
7tmA_MC5R cd15354
melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G ...
58-338 4.20e-08

melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320476 [Multi-domain]  Cd Length: 270  Bit Score: 53.79  E-value: 4.20e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  58 NLLVLATILKVRTFHRVPHNLVASMAISDVLVAVL-VMPLSLVHELSGRRWQLG----RRLCQLWIACDVLCCTASIWNV 132
Cdd:cd15354  18 NILVILAIVKNKNLHSPMYFFVCSLAVADMLVSVSnAWETITIYLLNNRHLVIEdafvRHIDNVFDSLICISVVASMCSL 97
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 133 TAIALDRYWSITRHLEYTLRTRKRVSNVMILLTWALSTVISLAPLLFGwgetysepseecqvsrEPSYTVFSTVGAFYLP 212
Cdd:cd15354  98 LAIAVDRYVTIFYALRYHNIMTVRRAGIIIACIWTFCTGCGIIFILYS----------------ESTYVIICLITMFFAM 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 213 LCVVLFVYWKIYRAAKfrmgsRKTNSVSPVPEAVEVknatqhpqmvftvrhatvtfqtegdtwREQKEQRAALMVGILIG 292
Cdd:cd15354 162 LFLMVSLYIHMFLLAR-----THVKRIAALPGYNSV---------------------------RQRTSMKGAVTLTILLG 209
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 84370345 293 VFVLCWFPFFVTELISPLCSWDVPAI----WKSIFLWLGYSNSFFNPLIY 338
Cdd:cd15354 210 IFIVCWAPFFLHLILMISCPQNLYCVcfmsHFNMYLILIMCNSVIDPLIY 259
7tmA_FMRFamide_R-like cd14978
FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...
41-349 4.93e-08

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.


Pssm-ID: 410630 [Multi-domain]  Cd Length: 299  Bit Score: 53.79  E-value: 4.93e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  41 VLVLTLLGFLAAATftwNLLVLAtilkvRTFHRVPHNLV-ASMAISDVLVAVLVMPLSLVHELsgrRWQLGRRLCQLWIA 119
Cdd:cd14978   7 LPVICIFGIIGNIL---NLVVLT-----RKSMRSSTNVYlAALAVSDILVLLSALPLFLLPYI---ADYSSSFLSYFYAY 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 120 CDVL-------CCTASIWNVTAIALDRYWSITRHLEY-TLRTRKRVSNVmILLTWALSTVISLaPLLFGW--GETYSEPS 189
Cdd:cd14978  76 FLPYiyplantFQTASVWLTVALTVERYIAVCHPLKArTWCTPRRARRV-ILIIIIFSLLLNL-PRFFEYevVECENCNN 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 190 EECQVSREPS-----------YTVFSTVGAFYLPLCVVLF----VYWKIYRAAKFRMGSRKTNSVSPVpeavevknatqh 254
Cdd:cd14978 154 NSYYYVIPTLlrqnetyllkyYFWLYAIFVVLLPFILLLIlnilLIRALRKSKKRRRLLRRRRRLLSR------------ 221
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 255 pqmvftvrhatvtfqtegdtwREQKEQRAALMVGILIGVFVLCWFPFFVTELISPLCSWDVP----AIWKSIFLWLGYSN 330
Cdd:cd14978 222 ---------------------SQRRERRTTIMLIAVVIVFLICNLPAGILNILEAIFGESFLspiyQLLGDISNLLVVLN 280
                       330
                ....*....|....*....
gi 84370345 331 SFFNPLIYTAFNRSYSSAF 349
Cdd:cd14978 281 SAVNFIIYCLFSSKFRRTF 299
7tmA_V1bR cd15386
vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G ...
40-342 6.25e-08

vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; The V1b receptor is specifically expressed in corticotropes of the anterior pituitary and plays a critical role in regulating the activity of hypothalamic-pituitary-adrenal axis, a key part of the neuroendocrine system that controls reactions to stress, by maintaining adrenocorticotropic hormone (ACTH) and corticosterone levels. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320508 [Multi-domain]  Cd Length: 302  Bit Score: 53.26  E-value: 6.25e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  40 RVLVLTLLGFLAAATfTWNLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSgRRWQLGRRLCQLWIA 119
Cdd:cd15386   1 KVEIGVLAAILVVAT-AGNLAVLLAMYRMRRKMSRMHLFVLHLALTDLVVALFQVLPQLIWEIT-YRFQGPDLLCRAVKY 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 120 CDVLCCTASIWNVTAIALDRYWSITRHLEyTLRTRKRVSNVMILLTWALSTVISLaPLLFGWGETYSEPSE---ECQVSR 196
Cdd:cd15386  79 LQVLSMFASTYMLIMMTVDRYIAVCHPLR-TLQQPSRQAYLMIGATWLLSCILSL-PQVFIFSLREVDQGSgvlDCWADF 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 197 EPS-----YTVFSTVGAFYLPLCVVLFVY----WKIYRAAKFRMGSRKtnsvspvpEAVEVKNATQHPQMVFTVRHATvt 267
Cdd:cd15386 157 GFPwgakaYITWTTLSIFVLPVAILIVCYslicYEICKNLKGKTQTSR--------SEGGGWRTQGMPSRVSSVRTIS-- 226
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 268 fqtegdtwreQKEQRAALMVGILIGVFVLCWFPFFVTELISplcSWDVPA-------IWKSIFLWLGYSNSFFNPLIYTA 340
Cdd:cd15386 227 ----------RAKIRTVKMTFVIVLAYIACWAPFFSVQMWS---VWDENApdedssdFAFTITMLLASLSSCCNPWIYMF 293

                ..
gi 84370345 341 FN 342
Cdd:cd15386 294 FS 295
7tmA_Galanin_R-like cd14971
galanin receptor and related proteins, member of the class A family of seven-transmembrane G ...
41-349 7.04e-08

galanin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled galanin receptors, kisspeptin receptor and allatostatin-A receptor (AstA-R) in insects. These receptors, which are members of the class A of seven transmembrane GPCRs, share a high degree of sequence homology among themselves. The galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, eating disorders, and epilepsy, among many others. KiSS1-derived peptide receptor (also known as GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. AstA-R is a G-protein coupled receptor that binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320102 [Multi-domain]  Cd Length: 281  Bit Score: 53.24  E-value: 7.04e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  41 VLVLTLLGFLAAATFTWNLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPL-SLVHELsgRRWQLGRRLCQLWIA 119
Cdd:cd14971   1 WIVPLFFALIFLLGLVGNSLVILVVARNKPMRSTTNLFILNLAVADLTFLLFCVPFtATIYPL--PGWVFGDFMCKFVHY 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 120 CDVLCCTASIWNVTAIALDRYWSITRHLEYTLRTRKRVSNVMILLTWALSTVISlAPLLFGWGETYSEPSEECQVS---- 195
Cdd:cd14971  79 FQQVSMHASIFTLVAMSLDRFLAVVYPLRSLHIRTPRNALAASGCIWVVSLAVA-APVLALHRLRNYTPGNRTVCSeawp 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 196 ---REPSYTVFSTVGAFYLPLCVVLFVYWKIYRaakfRMGSrktnsvSPVPEAVEVKNatqhpqmvftvrhatvtfqteg 272
Cdd:cd14971 158 sraHRRAFALCTFLFGYLLPLLLICVCYAAMLR----HLWR------VAVRPVLSEGS---------------------- 205
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 273 dtwrEQKEQRAALMVGILIGVFVLCWFPFFVTELIS-----PLCSWDVPA-IWKSIflwLGYSNSFFNPLIYTAFNRSYS 346
Cdd:cd14971 206 ----RRAKRKVTRLVLVVVVLFAACWGPIHAILLLValgpfPLTYATYALrIWAHC---LAYSNSAVNPVLYAFLSEHFR 278

                ...
gi 84370345 347 SAF 349
Cdd:cd14971 279 KAF 281
7tmA_MC4R cd15353
melanocortin receptor subtype 4, member of the class A family of seven-transmembrane G ...
58-338 7.25e-08

melanocortin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320475 [Multi-domain]  Cd Length: 269  Bit Score: 52.99  E-value: 7.25e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  58 NLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHEL-SGRRWQLGRRLCQLWIACDVLCCT---ASIWNVT 133
Cdd:cd15353  18 NILVIAAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETVVITLlNGNDTDAQSFTVNIDNVIDSVICSsllASICSLL 97
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 134 AIALDRYWSITRHLEYTLRTRKRVSNVMILLTWALSTVISLAPLLFGwgetysepseecqvsrEPSYTVFSTVGAFYLPL 213
Cdd:cd15353  98 SIAVDRYFTIFYALQYHNIMTVRRAGVIITCIWTACTVSGVLFIIYS----------------DSSVVIICLISMFFTML 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 214 CVVLFVYWKIYRAAKFRMgsrKTNSVSPVPEAVevknatqhpqmvftvrhatvtfqtegdtwREQKEQRAALMVGILIGV 293
Cdd:cd15353 162 ALMASLYVHMFLLARLHI---KRIAVLPGTGPI-----------------------------RQGANMKGAITLTILLGV 209
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 84370345 294 FVLCWFPFFVTELISPLCSWDVPAIW----KSIFLWLGYSNSFFNPLIY 338
Cdd:cd15353 210 FVVCWAPFFLHLIFYISCPRNPYCVCfmshFNMYLILIMCNSVIDPLIY 258
7tmA_GPR12 cd15961
G protein-coupled receptor 12, member of the class A family of seven-transmembrane G ...
78-349 8.26e-08

G protein-coupled receptor 12, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3.


Pssm-ID: 320627 [Multi-domain]  Cd Length: 268  Bit Score: 52.72  E-value: 8.26e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  78 LVASMAISDVLVAV-LVMPLSLVHELSGRRWQLgrrlcqLWIACDVLCCTASIWNVTAIALDRYWSITRHLEYTLRTRKR 156
Cdd:cd15961  38 LIGSLALADLLAGIgLILNFIFAYLLQSEAAKL------VTVGLIVASFSASVCSLLAITVDRYLSLYYALTYNSERTVT 111
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 157 VSNVMILLTWALSTVISLAPLLfGWGETYSEPSeeCQVSREPSYTVFSTVG-AFYLPLCVVLFVYWKIyraakfrmgsrk 235
Cdd:cd15961 112 FTYVMLVLLWGASICLGLLPVM-GWNCLADEST--CSVVRPLTKNNAAILSvSFLLMFALMLQLYIQI------------ 176
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 236 tnsvspvpeaveVKNATQHPQMVFTVRH--ATVTFQTegdtwreqkEQRAALMVGILIGVFVLCWFPFFVTELISplcSW 313
Cdd:cd15961 177 ------------CKIVMRHAHQIALQHHflATSHYVT---------TRKGVSTLAIILGTFAACWMPFTLYSLIA---DY 232
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 84370345 314 DVPAIWKSIFLWLGYSNSFFNPLIYTAFNRSYSSAF 349
Cdd:cd15961 233 TYPSIYTYATLLPATYNSIINPVIYAFRNQEIQKAL 268
7tmA_GPR3_GPR6_GPR12-like cd15100
G protein-coupled receptors 3, 6, 12, and related proteins, member of the class A family of ...
58-338 8.85e-08

G protein-coupled receptors 3, 6, 12, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3. Also included in this subfamily is GPRx, also known as GPR185, which involved in the maintenance of meiotic arrest in frog oocytes.


Pssm-ID: 320228 [Multi-domain]  Cd Length: 268  Bit Score: 52.86  E-value: 8.85e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  58 NLLVLATILKVRTFHRVPHNLVASMAISDVLVAV-LVMPLSLVHELSGRRWQLGRrlcqlwIACDVLCCTASIWNVTAIA 136
Cdd:cd15100  18 NAIVVAIIFSTPSLRAPMFLLIGSLALADLLAGLgLILHFVFRYCVYSEALSLVS------VGLLVAAFSASVCSLLAIT 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 137 LDRYWSITRHLEYTLRTRKRVSNVMILLTWALSTVISLAPLLfGWGETYSEPSeeCQVSREPSYTVFSTV-GAFYLPLCV 215
Cdd:cd15100  92 VDRYLSLYNALTYYSERTLTFTYVMLALLWTLALGLGLLPVL-GWNCLREGSS--CSVVRPLTKNHLAVLaVAFLLVFAL 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 216 VLFVYWKIYRAakfrmgsrktnsvspvpeavevknATQHPQMVFTVRHATVTFQTegdtwreQKEQRAALMVGILIGVFV 295
Cdd:cd15100 169 MLQLYAQICRI------------------------VLRHAHQIALQRHFLAPSHY-------VATRKGVSTLALILGTFA 217
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 84370345 296 LCWFPFFVTELISplcSWDVPAIWKSIFLWLGYSNSFFNPLIY 338
Cdd:cd15100 218 ACWIPFAVYCLLG---DGSSPALYTYATLLPATYNSMINPIIY 257
7tmA_Cannabinoid_R cd15099
cannabinoid receptors, member of the class A family of seven-transmembrane G protein-coupled ...
45-349 9.36e-08

cannabinoid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cannabinoid receptors belong to the class A G-protein coupled receptor superfamily. Two types of cannabinoid receptors, CB1 and CB2, have been identified so far. They are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 320227 [Multi-domain]  Cd Length: 281  Bit Score: 52.92  E-value: 9.36e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  45 TLLGFLaaaTFTWNLLVLATILKVRTFHRVPHNL-VASMAISDVLVAVL-VMPLSLVHELSGRRwqlGRRLCQLWIACDV 122
Cdd:cd15099   8 FLAGPV---TFLENILVLLTILSSTALRRRPSYLfIGSLALADMLASVIfTISFLDFHVFHQRD---SRNLFLFKLGGVT 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 123 LCCTASIWNVTAIALDRYWSITRHLEYTLRTRKRVSNVMILLTWALSTVISLAPLLfGWG-ETYSEPSEECQVSREPSYT 201
Cdd:cd15099  82 MAFTASVGSLLLTALDRYLCIYQPSNYKLLVTRTRAKVAILLMWCVTIIISFLPLM-GWRcKTWDSPCSRLFPYIDRHYL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 202 VFST-VGAFYLPLCVVLFVY--WKIYRAAKfRMGSRKTNSVSPVPEAvevknatqhpqmvftvrhatvtfqtegdtwREQ 278
Cdd:cd15099 161 ASWTgLQLVLLFLIIYAYPYilWKAHRHEA-NMGGPKLGRQQVKGQA------------------------------RMR 209
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 84370345 279 KEQRAALMVGILIGVFVLCWFPFFVTELISPLCSwdVPAIWKSIFLW---LGYSNSFFNPLIYTAFNRSYSSAF 349
Cdd:cd15099 210 MDIRLAKTLSLILLVLAICWLPVLAFMLVDVRVT--LTNKQKRMFAFcsmLCLVNSCVNPIIYALRSRELRGAM 281
7tmA_GPR151 cd15002
G protein-coupled receptor 151, member of the class A family of seven-transmembrane G ...
42-237 1.34e-07

G protein-coupled receptor 151, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 151 (GRP151) is an orphan receptor of unknown function. Its expression is conserved in habenular axonal projections of vertebrates and may be a promising novel target for psychiatric drug development. GPR151 shows high sequence similarity with galanin receptors (GALR). GPR151 is a member of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320133 [Multi-domain]  Cd Length: 280  Bit Score: 52.41  E-value: 1.34e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  42 LVLTLLGFLAAATFTWNLLVLATIL--KVRTFHRVPHNLVASMAISDVLVAVLVMPLsLVHELSGRRWQLGRRLCQLWIA 119
Cdd:cd15002   1 LVPILLGVICLLGFAGNLMVIGILLnnARKGKPSLIDSLILNLSAADLLLLLFSVPF-RAAAYSKGSWPLGWFVCKTADW 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 120 CDVLCCTASIWNVTAIALDRYWSITRHLEYTLRTRKRVSNVmILLTWALSTVISLaPLLFGWGETYSEPSEECQVS---- 195
Cdd:cd15002  80 FGHACMAAKSFTIAVLAKACYMYVVNPTKQVTIKQRRITAV-VASIWVPACLLPL-PQWLFRTVKQSEGVYLCILCippl 157
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
gi 84370345 196 REPSYTVFSTV---GAFYLPLCVVLFVYWKIYRAAKFRmgSRKTN 237
Cdd:cd15002 158 AHEFMSAFVKLyplFVFCLPLTFALFYFWRAYGQCQRR--GTKTQ 200
7tmA_ETH-R cd14997
ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G ...
58-349 1.76e-07

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the ecdysis-triggering hormone receptors found in insects, which are members of the class A family of seven-transmembrane G-protein coupled receptors. Ecdysis-triggering hormones are vital regulatory signals that govern the stereotypic physiological sequence leading to cuticle shedding in insects. Thus, the ETH signaling system has been a target for the design of more sophisticated insect-selective pest control strategies. Two subtypes of ecdysis-triggering hormone receptor were identified in Drosophila melanogaster. Blood-borne ecdysis-triggering hormone (ETH) activates the behavioral sequence through direct actions on the central nervous system. In insects, ecdysis is thought to be controlled by the interaction between peptide hormones; in particular between ecdysis-triggering hormone (ETH) from the periphery and eclosion hormone (EH) and crustacean cardioactive peptide (CCAP) from the central nervous system. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320128 [Multi-domain]  Cd Length: 294  Bit Score: 51.91  E-value: 1.76e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  58 NLLVLATILKVRTFhRVPHN-LVASMAISDVLVAVLVMPLSLVHELSGRRWQLGRRLCQLWIACDVLCCTASIWNVTAIA 136
Cdd:cd14997  18 NVLVGIVVWKNKDM-RTPTNiFLVNLSVADLLVLLVCMPVALVETWAREPWLLGEFMCKLVPFVELTVAHASVLTILAIS 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 137 LDRYWSITRHLE--YTLrTRKRVSnVMILLTWALSTVISLaPLLF-------GWGETYSEPSEECQVSREPS--YTVFST 205
Cdd:cd14997  97 FERYYAICHPLQakYVC-TKRRAL-VIIALIWLLALLTSS-PVLFitefkeeDFNDGTPVAVCRTPADTFWKvaYILSTI 173
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 206 VGAFYLPLCVVLFVYWKIyraakfrmgSRKTNSVspvpeavevkNATQHPQMVFTVRHatvtfqtegdtwREQKEQRAAL 285
Cdd:cd14997 174 VVFFVVPLAILSGLYSVI---------CRRLVGH----------PALESRRADAANRH------------TLRSRRQVVY 222
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 84370345 286 MVGILIGVFVLCWFPFFVTELISPLCS-WDVPAIWKSIFLWL-------GYSNSFFNPLIYTAFNRSYSSAF 349
Cdd:cd14997 223 MLITVVVLFFVCLLPFRVVTLWIIFAPdEDLQALGLEGYLNLlvfcrvmVYLNSALNPILYNLMSTKFRSAF 294
7tmA_NOFQ_opioid_R cd15092
nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G ...
58-349 1.81e-07

nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The nociceptin (NOP) receptor binds nociceptin or orphanin FQ, a 17 amino acid endogenous neuropeptide. The NOP receptor is involved in the modulation of various brain activities including instinctive and emotional behaviors. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320220 [Multi-domain]  Cd Length: 279  Bit Score: 51.79  E-value: 1.81e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  58 NLLVLATILKVRTFHRVPHNLVASMAISDVLVaVLVMPLSLVHELSGRrWQLGRRLCQLWIACDVLCCTASIWNVTAIAL 137
Cdd:cd15092  18 NCLVMYVILRHTKMKTATNIYIFNLALADTLV-LLTLPFQGTDIFLGF-WPFGNALCKTVIAIDYYNMFTSTFTLTAMSV 95
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 138 DRYWSI---TRHLEYTLRTRKRVSNVMIlltWALSTVISLAPLLFGWGETYSEpSEECQVSREPSYTVFSTVGAfylpLC 214
Cdd:cd15092  96 DRYVAIchpIKALDVRTPHKAKVVNVCI---WALASVVGVPVMVMGSAQVEDE-EIECLVEIPTPQDYWDPVFG----IC 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 215 VVLFVYWkiyraakfrmgsrktnsvspVPEAVevkNATQHPQMVFTVRHATVtfqTEGDTWREQKEQRAALMVGILIGVF 294
Cdd:cd15092 168 VFLFSFI--------------------IPVLI---ISVCYSLMIRRLRGVRL---LSGSKEKDRNLRRITRLVLVVVAVF 221
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 84370345 295 VLCWFPFFVTELISPL---CSWDVPAIWKSIFLWLGYSNSFFNPLIYTAFNRSYSSAF 349
Cdd:cd15092 222 VGCWTPIQIFVLAQGLgvqPSSETAVAILRFCTALGYVNSSLNPVLYAFLDENFKACF 279
7tmA_Delta_opioid_R cd15089
opioid receptor subtype delta, member of the class A family of seven-transmembrane G ...
41-349 1.98e-07

opioid receptor subtype delta, member of the class A family of seven-transmembrane G protein-coupled receptors; The delta-opioid receptor binds the endogenous pentapeptide ligands such as enkephalins and produces antidepressant-like effects. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320217 [Multi-domain]  Cd Length: 281  Bit Score: 51.87  E-value: 1.98e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  41 VLVLTLLGFLAAATFTWNLLVLATILKVRTFHRVPHNLVASMAISDVLvAVLVMPLSLVHELSGRrWQLGRRLCQLWIAC 120
Cdd:cd15089   1 IAITALYSVVCVVGLLGNVLVMYGIVRYTKMKTATNIYIFNLALADAL-ATSTLPFQSAKYLMET-WPFGELLCKAVLSI 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 121 DVLCCTASIWNVTAIALDRYWSI---TRHLEYTLRTRKRVSNVMIlltWALSTVISLAPLLFGWGETYSEPSEECQVSRE 197
Cdd:cd15089  79 DYYNMFTSIFTLTMMSVDRYIAVchpVKALDFRTPAKAKLINICI---WVLSSGVGVPIMVMAVTKTPRDGAVVCMLQFP 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 198 PSYTVFSTVgafyLPLCVVLFVYwkiyraakfrmgsrktnsVSPVpeavevknatqhpqMVFTVRHATVTFQTE------ 271
Cdd:cd15089 156 SPSWYWDTV----TKICVFIFAF------------------VVPI--------------LVITVCYGLMILRLRsvrlls 199
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 272 GDTWREQKEQRAALMVGILIGVFVLCWFPFFVTELISPLCSWD-----VPAIWKsIFLWLGYSNSFFNPLIYTAFNRSYS 346
Cdd:cd15089 200 GSKEKDRNLRRITRMVLVVVAAFIICWTPIHIFVIVWTLVDIDrrnplVVAALH-LCIALGYANSSLNPVLYAFLDENFK 278

                ...
gi 84370345 347 SAF 349
Cdd:cd15089 279 RCF 281
7tmA_GPR6 cd15962
G protein-coupled receptor 6, member of the class A family of seven-transmembrane G ...
58-343 2.15e-07

G protein-coupled receptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3.


Pssm-ID: 320628 [Multi-domain]  Cd Length: 268  Bit Score: 51.47  E-value: 2.15e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  58 NLLVLATILKVRTFHRVPHNLVASMAISDVLVAV-LVMPLSLVHELSGRRWQLgrrlcqLWIACDVLCCTASIWNVTAIA 136
Cdd:cd15962  18 NAIVVAIIFYTPTLRTPMFVLIGSLATADLLAGCgLILNFVFQYVIQSETISL------ITVGFLVASFTASVSSLLAIT 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 137 LDRYWSITRHLEYTLRTRKRVSNVMILLTWALSTVISLAPLLfGWgETYSEPSeECQVSR---EPSYTVFSTvgAFYLPL 213
Cdd:cd15962  92 VDRYLSLYNALTYYSEKTVLGVHLMLAATWGVSLCLGLLPVL-GW-NCLEERA-SCSIVRpltKSNVTLLSA--SFFFIF 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 214 CVVLFVYWKIYRAAkfrmgSRKTNSVspvpeavevknATQhpQMVFTVRHATVTfqtegdtwreqkeQRAALMVGILIGV 293
Cdd:cd15962 167 ILMLHLYIKICKIV-----CRHAHQI-----------ALQ--QHFLTASHYVAT-------------KKGVSTLAIILGT 215
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 84370345 294 FVLCWFPFFVTELISplcSWDVPAIWKSIFLWLGYSNSFFNPLIYTAFNR 343
Cdd:cd15962 216 FGASWLPFAIYCVVG---DHEYPAVYTYATLLPATYNSMINPIIYAYRNQ 262
7tmA_LWS_opsin cd15081
long wave-sensitive opsins, member of the class A family of seven-transmembrane G ...
50-345 2.58e-07

long wave-sensitive opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Long Wave-Sensitive opsin is also called red-sensitive opsin or red cone photoreceptor pigment, which mediates visual transduction in response to light at long wavelengths. Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320209 [Multi-domain]  Cd Length: 292  Bit Score: 51.45  E-value: 2.58e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  50 LAAATFTwNLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSGrRWQLGRRLCQLWIACDVLCCTASI 129
Cdd:cd15081  23 VFASVFT-NGLVLVATLKFKKLRHPLNWILVNLAIADLGETVIASTISVVNQIFG-YFILGHPMCVLEGFTVSVCGITGL 100
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 130 WNVTAIALDRYWSITRHLEyTLRTRKRVSNVMILLTWALSTVISlAPLLFGW------GETYSEPSEECQVSREP---SY 200
Cdd:cd15081 101 WSLTIISWERWVVVCKPFG-NIKFDGKLAIVGIIFSWVWSAVWC-APPIFGWsrywphGLKTSCGPDVFSGSSDPgvqSY 178
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 201 TVFSTVGAFYLPLCVVLFVYWKIYRAAkfrmgsrktnsvspvpeavevknatqhpqmvftvrHATVTFQTEGDTwREQKE 280
Cdd:cd15081 179 MIVLMITCCIIPLAIIILCYLQVWLAI-----------------------------------RAVAQQQKESES-TQKAE 222
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 84370345 281 QRAALMVGILIGVFVLCWFPF-FVTELISPLCSWDVPAIWKSIFLWLGYSNSFFNPLIYTAFNRSY 345
Cdd:cd15081 223 KEVSRMVVVMIFAYCFCWGPYtFFACFAAANPGYAFHPLAAALPAYFAKSATIYNPIIYVFMNRQF 288
7tmA_Pinopsin cd15084
non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled ...
43-347 2.85e-07

non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Pinopsins are found in the pineal organ of birds, reptiles and amphibians, but are absent from teleosts and mammals. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Pinopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320212 [Multi-domain]  Cd Length: 295  Bit Score: 51.40  E-value: 2.85e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  43 VLTLLGFLAAATFTWNLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSGRrWQLGRRLCQLWIACDV 122
Cdd:cd15084  13 VAVLMGMVVALASFVNGLVIVVSIKYKKLRSPLNYILVNLAVADLLVTLFGSSVSFSNNIVGF-FVFGKTMCEFEGFMVS 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 123 LCCTASIWNVTAIALDRYWSITRHL-EYTLRTRKRVSNVMILLTWALstvISLAPLLFGWGETYSE-------PSEECQV 194
Cdd:cd15084  92 LTGIVGLWSLAILAFERYLVICKPMgDFRFQQRHAVSGCAFTWGWSL---LWTSPPLFGWSSYVPEglrtscgPNWYTGG 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 195 SREPSYTVFSTVGAFYLPLCVVLFVYwkiyraakfrmgsrktnsvspvpeavevknatqhPQMVFTVRhATVTFQTEGDT 274
Cdd:cd15084 169 TNNNSYILALFVTCFALPLSTIIFSY----------------------------------SNLLLTLR-AVAAQQKESET 213
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 84370345 275 wREQKEQRAALMVGILIGVFVLCWFPFFVTELISPLCSWDV--PAIwKSIFLWLGYSNSFFNPLIYTAFNRSYSS 347
Cdd:cd15084 214 -TQRAEKEVTRMVIAMVMAFLICWLPYATFAMVVATNKDVViqPTL-ASLPSYFSKTATVYNPIIYVFMNKQFRS 286
7tmA_CB1 cd15340
cannabinoid receptor subtype 1, member of the class A family of seven-transmembrane G ...
38-349 5.19e-07

cannabinoid receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Cannabinoid receptors belong to the class A G-protein coupled receptor superfamily. Two types of cannabinoid receptors, CB1 and CB2, have been identified so far. They are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 320462 [Multi-domain]  Cd Length: 292  Bit Score: 50.68  E-value: 5.19e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  38 AFRVLVLTLLGFlaaaTFTWNLLVLATILKVRTFH-RVPHNLVASMAISDVLVAVLVMPLSLVHELSGRRWQLGRRLCQL 116
Cdd:cd15340   2 AIAVLSLTLGTF----TVLENLLVLCVILHSRSLRcRPSYHFIGSLAVADLLGSVIFVYSFLDFHVFHRKDSPNVFLFKL 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 117 wiACDVLCCTASIWNVTAIALDRYWSITRHLEYTLRTRKRVSNVMILLTWALSTVISLAPLLfGWgetysepseECQVSR 196
Cdd:cd15340  78 --GGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRTKAVIAFCVMWTIAIVIAVLPLL-GW---------NCKKLN 145
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 197 EPSYTVFSTVGAFYLPLCV-------------VLFVYWKIYRAAkFRMGSRKTNSVSPVPEAVEVKNATQHPQmvftvrh 263
Cdd:cd15340 146 SVCSDIFPLIDETYLMFWIgvtsvlllfivyaYMYILWKAHHHA-VRMLQRGTQKSIIVYTSEDGKVQTTRPD------- 217
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 264 atvtfQTEGDTwreqkeqRAALMVGILIGVFVLCWFPFFVTELISPLcsWDVPAIWKSIFLW---LGYSNSFFNPLIYTA 340
Cdd:cd15340 218 -----QTRMDI-------RLAKTLVLILVVLIICWGPLLAIMVYDVF--GKMNKLIKTVFAFcsmLCLLNSTVNPIIYAL 283

                ....*....
gi 84370345 341 FNRSYSSAF 349
Cdd:cd15340 284 RSKDLRHAF 292
7tmA_Bradykinin_R cd15189
bradykinin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
41-338 5.93e-07

bradykinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320317 [Multi-domain]  Cd Length: 284  Bit Score: 50.16  E-value: 5.93e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  41 VLVLTLLGFLAaatftwNLLVLATILKVRTFHRVPHNLVASMAISDvLVAVLVMPLSLVHELSGRRWQLGRRLCQLWIAC 120
Cdd:cd15189   7 IFSLCLFGLLG------NLFVLLVFLLHRRRLTVAEIYLGNLAAAD-LVFVSGLPFWAMNILNQFNWPFGELLCRVVNGV 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 121 DVLCCTASIWNVTAIALDRYWSITRHLEYTLRTRKRVSNVMILLTWALSTVISLAPLLFGWGETYSE-PSEECQVSR--- 196
Cdd:cd15189  80 IKVNLYTSIYLLVMISQDRYLALVKTMAARRLRRRRYAKLICVLIWVVGLLLSIPTFLLRKIKAIPDlNITACVLLYphe 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 197 --EPSYTVFSTVGAFYLPLCVVLFVYWKIYRAAKFRmgsrktnsvspvpeavevknatqhpqmvftvrhatvtfqTEGDT 274
Cdd:cd15189 160 awHFAHIVLLNIVGFLLPLLVITFCNYNILQALRTR---------------------------------------EESTR 200
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 84370345 275 WREQKEQRAALMVGILIGVFVLCWFPFFVTELISPL--------CSW-DVPAIWKSIFLWLGYSNSFFNPLIY 338
Cdd:cd15189 201 CEDRNDSKATALVLAVTLLFLVCWGPYHFFTFLDFLfdvgvldeCFWeHFIDIGLQLAVFLAFSNSCLNPVLY 273
7tmA_S1PR3_Edg3 cd15345
sphingosine-1-phosphate receptor subtype 3 (S1PR3 or S1P3), also called endothelial ...
58-349 7.71e-07

sphingosine-1-phosphate receptor subtype 3 (S1PR3 or S1P3), also called endothelial differentiation gene 3 (Edg3), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320467 [Multi-domain]  Cd Length: 270  Bit Score: 49.82  E-value: 7.71e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  58 NLLVLATILKVRTFHRVPHNLVASMAISDVLVAV-----LVMPLSLVHELSGRRWQLgrRLCQLWIACdvlccTASIWNV 132
Cdd:cd15345  18 NLMVLIAIWKNNRFHNRMYFFIGNLALCDLLAGIaykvnILMSGKKTFSLSPTQWFL--REGSMFVAL-----GASTFSL 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 133 TAIALDRYWSITRHLEYTLRTRKRVSnVMILLTWALSTVISLAPLLfGWGETYSEPSEECQVSREPSYTVFSTVGAFYLP 212
Cdd:cd15345  91 LAIAIERHLTMIKMRPYDANKRYRVF-LLIGTCWLISVLLGALPIL-GWNCLDNLPDCSTILPLYSKKYVAFCISIFIAI 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 213 LCVVLFVYWKIYRAAKfrMGSRKTNSVSPvpeavevknatqhpqmvftvrhatvtfqtegdtwreqKEQRAALM--VGIL 290
Cdd:cd15345 169 LVAIVILYARIYILVK--SSSRRVTNHRN-------------------------------------SERSMALLrtVVIV 209
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 84370345 291 IGVFVLCWFPFFVTELISPLCS-WDVPAIWKS-IFLWLGYSNSFFNPLIYTAFNRSYSSAF 349
Cdd:cd15345 210 VGVFIACWSPLFILLLIDVACEvKQCPILYKAdWFIALAVLNSAMNPIIYTLASKEMRRAF 270
7tmA_Parietopsin cd15085
non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled ...
43-345 8.90e-07

non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Parietopsin is a non-visual green light-sensitive opsin that was initially identified in the parietal eye of lizards. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Parietopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.


Pssm-ID: 320213 [Multi-domain]  Cd Length: 280  Bit Score: 49.85  E-value: 8.90e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  43 VLTLLGFLAAATFTWN-LLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSGRRWqLGRRLCQLWIACD 121
Cdd:cd15085   2 ILSFLMFLNATFSIFNnVLVIAVTLKNPQLRNPINIFILNLSFSDLMMALCGTTIVTVTNYEGYFY-LGDAFCIFQGFAV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 122 VLCCTASIWNVTAIALDRYWSITRHLEyTLRTRKRVSNVMILLTWALSTVISLAPlLFGWGETYSEPSE-ECQVSREP-- 198
Cdd:cd15085  81 NYFGIVSLWSLTLLAYERYNVVCKPMG-GLKLSTKRGYQGLLFIWLFCLFWAVAP-LFGWSSYGPEGVQtSCSIGWEErs 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 199 ----SYTVFSTVGAFYLPLCVVLFVYWKIYRaakfrmgsrktnsvspvpeavevknatqhpqmvfTVRHATVTFQTEGDT 274
Cdd:cd15085 159 wsnySYLILYFLMCFVIPVAIIGFSYGNVLR----------------------------------SLHKLNKKIEQQGGK 204
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 84370345 275 WREQKEQRAALMVGILIGVFVLCWFPFFVTELI---SPLCSwdVPAIWKSIFLWLGYSNSFFNPLIYTAFNRSY 345
Cdd:cd15085 205 NCPEEEERAVIMVLAMVIAFLICWLPYTVFALIvvvNPELS--ISPLAATMPTYFAKTSPVYNPIIYIFLNKQF 276
7tmA_NPFFR1 cd15981
neuropeptide FF receptor 1, member of the class A family of seven-transmembrane G ...
58-349 9.52e-07

neuropeptide FF receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320647 [Multi-domain]  Cd Length: 299  Bit Score: 49.82  E-value: 9.52e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  58 NLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSgRRWQLGRRLCQLWIACDVLCCTASIWNVTAIAL 137
Cdd:cd15981  18 NGLVCFIVLKNRQMRTVTNMFILNLAVSDLLVGIFCMPTTLVDNLI-TGWPFDNAMCKMSGLVQGMSVSASVFTLVAIAV 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 138 DRYWSITRHLEYTLRTRKRVsnVMILLTWALSTVI-----------------------SLAPLLFGWgETYSEPseecQV 194
Cdd:cd15981  97 ERFRCIVHPFRQKLTLRKAI--VTIVIIWVLALIImcpsavtltvtreehhfmvddynNSYPLYSCW-EAWPDT----EM 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 195 SREPSYTVFSTVGAFYLPLCVVLFVywkiyraakfRMGSRKTNSVSPVPEAVEvknatqhpqmvftvrhatvtfQTEGDT 274
Cdd:cd15981 170 RKIYTTVLFSHIYLAPLTLIVIMYA----------RIAFKLFKSSAPIRGSQG---------------------EEEEGR 218
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 275 WREQKEQRAALMVGILIGVFVLCWFPFFVTELISP---LCSWDVPAIWKSIF---LWLGYSNSFFNPLIYTAFNRSYSSA 348
Cdd:cd15981 219 RVSKRKIKVINMLIIVALFFTLSWLPLWTLMLLTDyghLSEDQLNLVTVYVFpfaHWLAFFNSSVNPIIYGYFNENFRRG 298

                .
gi 84370345 349 F 349
Cdd:cd15981 299 F 299
7tmA_ET_R-like cd14977
endothelin receptors and related proteins, member of the class A family of seven-transmembrane ...
58-349 9.58e-07

endothelin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes endothelin receptors, bombesin receptor subtype 3 (BRS-3), gastrin-releasing peptide receptor (GRPR), neuromedin B receptor (NMB-R), endothelin B receptor-like 2 (ETBR-LP-2), and GRP37. The endothelin receptors and related proteins are members of the seven transmembrane rhodopsin-like G-protein coupled receptor family (class A GPCRs) which activate multiple effectors via different types of G protein.


Pssm-ID: 320108 [Multi-domain]  Cd Length: 292  Bit Score: 49.73  E-value: 9.58e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  58 NLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSgRRWQLGRRLCQLWIACDVLCCTASIWNVTAIAL 137
Cdd:cd14977  18 NLMVLCIVCTNYYMRSVPNILIASLALGDLLLLLLCVPLNAYNLLT-KDWLFGDVMCKLVPFIQVTSLGVTVFSLCALSI 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 138 DRYWSITRHLEYTLRTRKRVSNVMILLTWALStVISLAPLLFGWGETYSEPSEECQVSREPSYTVFSTVGAFY------- 210
Cdd:cd14977  97 DRYRAAVNSMPMQTIGACLSTCVKLAVIWVGS-VLLAVPEAVLSTVARESSLDNSSLTVCIMKPSTPFAETYPkarswwl 175
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 211 ------LPLCVVLFVYWKIYRaakfRMGSRKTNSvspvpeavevknatqhpqmvftvrhatvtfqTEGDTWREQKEQRAA 284
Cdd:cd14977 176 fgcyfcLPLAFTAVCYLLMAR----TLIRAAKEY-------------------------------TRGTKKHMKQRRQLA 220
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 84370345 285 LMVGILIGVFVLCWFPFFVTELISPLCSWDVPAIWKS-------IFLWLGYSNSFFNPLIYTAFNRSYSSAF 349
Cdd:cd14977 221 KTVLCLVLVFAFCWLPEHISNILRATLYNEVLIDTRStldildlIGQFLSFFNSCVNPIALYLLSEPFRRAF 292
7tmA_RNL3R2 cd15925
relaxin-3 receptor 2 (RNL3R2), member of the class A family of seven-transmembrane G ...
41-348 1.06e-06

relaxin-3 receptor 2 (RNL3R2), member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled receptor RNL3R2 is also known as GPR100, GPR142, and relaxin family peptide receptor 4 (RXFP4). Insulin-like peptide 5 (INSL5) is an endogenous ligand for RNL3R2 and plays a role in fat and glucose metabolism. INSL5 is highly expressed in human rectal and colon tissues. RNL3R2 signals through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation.


Pssm-ID: 320591 [Multi-domain]  Cd Length: 283  Bit Score: 49.49  E-value: 1.06e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  41 VLVLTLLGFLAAATFTWNLLVLATILKVRTFHRVPHN-LVASMAISDVLVAvLVMPLSLVHELSGRRWQLGRRLCQLWIA 119
Cdd:cd15925   1 ILVALAYGLVCAIGLLGNLAVMYLLRNCARRAPPPIDvFVFNLALADFGFA-LTLPFWAVESALDFHWPFGGAMCKMVLT 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 120 CDVLCCTASIWNVTAIALDRYWSITRHLEYTLRTRKRVSNVMILLTWALSTVISLAPLLFgwGETYSEPSEECQVSREPS 199
Cdd:cd15925  80 ATVLNVYASVFLLTAMSVTRYWVVASAAGPGTHLSTFWAKIITLALWAAALLATVPTAIF--ATEGEVCGVELCLLKFPS 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 200 ------YTVFSTVGAFYLPLCVVLFVYWKIyraakfrmgsrktnsvspvpeavevknatqhpqMVFTVRHATvtfqtegD 273
Cdd:cd15925 158 nywlgaYHLQRVVVAFVVPLGVITTSYLLL---------------------------------LSFLQQHKV-------N 197
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 274 TWREQKEQRAALMVGILIGVFVLCWFPFFVTELISPLCSWD-VPaiWKSIF-----------LWLGYSNSFFNPLIYTAF 341
Cdd:cd15925 198 QNNRQRQSVIARSVRLVVASFFLCWFPNHVVTFWGVLVKFRaVP--WNSTFyfihtyvfpvtTCLAHSNSCLNPVLYCLM 275

                ....*..
gi 84370345 342 NRSYSSA 348
Cdd:cd15925 276 RREFRQA 282
7tmA_GPR3 cd15963
G protein-coupled receptor 3, member of the class A family of seven-transmembrane G ...
58-343 1.14e-06

G protein-coupled receptor 3, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3.


Pssm-ID: 320629 [Multi-domain]  Cd Length: 268  Bit Score: 49.50  E-value: 1.14e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  58 NLLVLATILKVRTFHRVPHNLVASMAISDVLVAV-LVMPLSLVHELSGRRWQLgrrlcqLWIACDVLCCTASIWNVTAIA 136
Cdd:cd15963  18 NAIVVAVIFYTPAFRAPMFLLIGSLATADLLAGLgLILHFAFVYCIQSAPVNL------VTVGLLAPSFTASVSSLLAIT 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 137 LDRYWSITRHLEYTLRTRKRVSNVMILLTWALSTVISLAPLLfGWgETYSEPSeECQVSREPSYTVFSTVG-AFYLPLCV 215
Cdd:cd15963  92 IDRYLSLYNALTYYSERTVTRTYIMLILTWGASLCLGLLPVV-GW-NCLKDPS-TCSVVKPLTKNHLVILSiSFFMVFAL 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 216 VLFVYWKIYRAakfrmgsrktnsvspvpeavevknATQHPQMVFTVRHATVTFQTegdtwreQKEQRAALMVGILIGVFV 295
Cdd:cd15963 169 MLQLYAQICRI------------------------VCRHAHQIALQRHFLPTSHY-------VTTRKGIATLAVILGTFA 217
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 84370345 296 LCWFPFFVTELispLCSWDVPAIWKSIFLWLGYSNSFFNPLIYTAFNR 343
Cdd:cd15963 218 SCWLPFAVYCL---LGDYTYPALYTYATLLPATYNSMINPIIYAFRNQ 262
7tmA_VA_opsin cd15082
non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane ...
39-345 1.42e-06

non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The vertebrate ancient (VA) opsin photopigments were originally identified in salmon and they appear to have diverged early in the evolution of vertebrate opsins. VA opsins are localized in the inner retina and the brain in teleosts. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extraretinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity, and body color change. The VA opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320210 [Multi-domain]  Cd Length: 291  Bit Score: 49.41  E-value: 1.42e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  39 FRVLVlTLLGFLAAATFTWNLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSGRRWqLGRRLCQLWI 118
Cdd:cd15082  13 FTVLA-ALMFVVTSLSLAENFAVMLVTFRFKQLRQPLNYIIVNLSVADFLVSLTGGTISFLTNARGYFF-LGVWACVLEG 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 119 ACDVLCCTASIWNVTAIALDRYWSITRHLEyTLRTRKRVSNVMILLTWALSTVISLAPLLfGWGE-------TYSEPSEE 191
Cdd:cd15082  91 FAVTFFGIVALWSLAVLAFERFFVICRPLG-NIRLQGKHAALGLLFVWTFSFIWTIPPVL-GWSSytvskigTTCEPNWY 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 192 CQVSREPSYTVFSTVGAFYLPLCVVLFVYWKIYraakfrmgsRKTNSVSpvpeavevknatqhpqmvftvrhatvtfQTE 271
Cdd:cd15082 169 SGNMHDHTYIITFFTTCFILPLGVIFVSYGKLL---------QKLRKVS----------------------------NTQ 211
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 84370345 272 GDTWREQK-EQRAALMVGILIGVFVLCWFPFFVTELISPLC-SWDVPAIWKSIFLWLGYSNSFFNPLIYTAFNRSY 345
Cdd:cd15082 212 GRLGNARKpERQVTRMVVVMIVAFMVCWTPYAAFSILVTAHpTIHLDPRLAAIPAFFSKTAAVYNPIIYVFMNKQF 287
7tmA_GPR15 cd15194
G protein-coupled receptor 15, member of the class A family of seven-transmembrane G ...
58-343 1.64e-06

G protein-coupled receptor 15, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR15, also called as Brother of Bonzo (BOB), is an orphan G-protein coupled receptor that was originally identified as a co-receptor for human immunodeficiency virus. GPR15 is upregulated in patients with rheumatoid arthritis and shares high sequence homology with angiotensin II type AT1 and AT2 receptors; however, its endogenous ligand is unknown. GPR15 controls homing of T cells, especially FOXP3(+) regulatory T cells, to the large intestine mucosa and thereby mediates local immune homeostasis. Moreover, GRP15-deficient mice were shown to be prone to develop more severe large intestine inflammation.


Pssm-ID: 320322 [Multi-domain]  Cd Length: 281  Bit Score: 49.08  E-value: 1.64e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  58 NLLVLATILKVRTFHRVPHNLVASMAISDvLVAVLVMPLSLVHELSGRRWQLGRRLCQLWIACDVLCCTASIWNVTAIAL 137
Cdd:cd15194  18 NAILMGALVFKRGVRRLIDIFISNLAASD-FIFLVTLPLWVDKEVVLGPWRSGSFLCKGSSYIISVNMYCSVFLLTCMSL 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 138 DRYWSITRHLEYTLRTRKRVSNVMILLTWALSTVISLAPLLFGWGETYSEPSEECQVSREPSYTVFSTVG---AFYLPLC 214
Cdd:cd15194  97 DRYLAIVLPLVSRKFRTKHNAKVCCTCVWMLSCLLGLPTLLSRELKKYEEKEYCNEDAGTPSKVIFSLVSlivAFFLPLL 176
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 215 VVLFVYWKIyraakfrmgsrktnsvspvpeavevknatqhpqmvftVRHATVTFQTEGDtwREQKEQRAALMVGILIGVF 294
Cdd:cd15194 177 SILTCYCTI-------------------------------------IWKLCHHYQKSGK--HQKKLRKSIKIVFIVVAAF 217
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 84370345 295 VLCWFPFFVTELIS---------PLCSWDVPAIWKSIFLWLGYSNSFFNPLIYTAFNR 343
Cdd:cd15194 218 VFSWMPFNLFKALAiasglqvevTCLPYTLAQLGMEVSAPLAFANSCANPFIYYFFDR 275
7tmA_NTSR1 cd15355
neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G ...
41-349 1.66e-06

neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320477 [Multi-domain]  Cd Length: 310  Bit Score: 49.08  E-value: 1.66e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  41 VLVLTLLGFLAAATFTWNLLVLATILK---VRTFHRVPHNLVASMAISDVLVAVLVMPLSL-----VHElsgrRWQLGRR 112
Cdd:cd15355   1 VLVTAIYLALFVVGTVGNSITLYTLARkksLQHLQSTVHYHLASLALSDLLILLLAMPVELynfiwVHH----PWAFGDA 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 113 LCQLWIACDVLCCTASIWNVTAIALDRYWSITRHLEY-TLRTRKRVSNVmILLTWALSTVISlAPLLFGWGETYSEPSEE 191
Cdd:cd15355  77 ACRGYYFLRDACTYATALNVASLSVERYLAICHPFKAkSLMSRSRTKKF-ISAIWLASALLA-IPMLFTMGEQNRSGTHP 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 192 CQ------VSREPSYTVFS--TVGAFYLPLCVVLFVywkiyraakfrmgsrktNSVSPVPEAVEVKNATQhPQMVFTVRH 263
Cdd:cd15355 155 GGlictpiVDTSTLKVVIQvnAFLSFLFPMLVISVL-----------------NTLIANQLTVMVNQAEQ-ENQVCTIGG 216
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 264 ATVTFQTEGDTWREQKEQRAALMVGILIGVFVLCWFPFFVTELIspLCSwdVPAIWKSIFLW------------LGYSNS 331
Cdd:cd15355 217 QRTVLSVSMEPGRVQSLRHGVLVLRAVVIAFVVCWLPYHVRRLM--FCY--VSDEQWTTFLYdfyhyfymltnvLFYVSS 292
                       330
                ....*....|....*...
gi 84370345 332 FFNPLIYTAFNRSYSSAF 349
Cdd:cd15355 293 AINPILYNLVSANFRQIF 310
7tmA_UII-R cd14999
urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled ...
43-345 1.79e-06

urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The urotensin-II receptor (UII-R, also known as the hypocretin receptor) is a member of the class A rhodopsin-like G-protein coupled receptors, which binds the peptide hormone urotensin-II. Urotensin II (UII) is a vasoactive somatostatin-like or cortistatin-like peptide hormone. However, despite the apparent structural similarity to these peptide hormones, they are not homologous to UII. Urotensin II was first identified in fish spinal cord, but later found in humans and other mammals. In fish, UII is secreted at the back part of the spinal cord, in a neurosecretory centre called uroneurapophysa, and is involved in the regulation of the renal and cardiovascular systems. In mammals, urotensin II is the most potent mammalian vasoconstrictor identified to date and causes contraction of arterial blood vessels, including the thoracic aorta. The urotensin II receptor is a rhodopsin-like G-protein coupled receptor, which binds urotensin-II. The receptor was previously known as GPR14, or sensory epithelial neuropeptide-like receptor (SENR). The UII receptor is expressed in the CNS (cerebellum and spinal cord), skeletal muscle, pancreas, heart, endothelium and vascular smooth muscle. It is involved in the pathophysiological control of cardiovascular function and may also influence CNS and endocrine functions. Binding of urotensin II to the receptor leads to activation of phospholipase C, through coupling to G(q/11) family proteins. The resulting increase in intracellular calcium may cause the contraction of vascular smooth muscle.


Pssm-ID: 320130 [Multi-domain]  Cd Length: 282  Bit Score: 48.98  E-value: 1.79e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  43 VLTLLGFLAAATFTWNLLVLATILKVRTFHRVphnLVASMAISDvLVAVLVMPLsLVHELSGRRWQLGRRLCQLWIACDV 122
Cdd:cd14999   5 VLSLMCVVGVAGNVYTLVVMCLSMRPRASMYV---YILNLALAD-LLYLLTIPF-YVSTYFLKKWYFGDVGCRLLFSLDF 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 123 LCCTASIWNVTAIALDRYWSITRHLEyTLRTRKRVSNVMILLTWALSTVISLAPLLF---GWGETYSEPSEECQVS--RE 197
Cdd:cd14999  80 LTMHASIFTLTVMSTERYLAVVKPLD-TVKRSKSYRKLLAGVIWLLSLLLTLPMAIMirlVTVEDKSGGSKRICLPtwSE 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 198 PSYTVFSTV---GAFYLPLCVVLFVY-------WKIYRAAKFRMGSRKTNsvspvpeavevknatqhpqmvftvrhatvt 267
Cdd:cd14999 159 ESYKVYLTLlfsTSIVIPGLVIGYLYirlarkyWLSQAAASNSSRKRLPK------------------------------ 208
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 268 fqtegdtwreqkeQRAALMVGILIGVFVLCWFPFFVTELIsPLCSWDVPAIWKSI----FLW--LGYSNSFFNPLIYTAF 341
Cdd:cd14999 209 -------------QKVLKMIFTIVLVFWACFLPFWIWQLL-YLYSPSLSLSPRTTtyvnYLLtcLTYSNSCINPFLYTLL 274

                ....
gi 84370345 342 NRSY 345
Cdd:cd14999 275 TKNY 278
7tmA_GPR65_TDAG8 cd15365
proton-sensing G protein-coupled receptor 65, member of the class A family of ...
81-228 1.82e-06

proton-sensing G protein-coupled receptor 65, member of the class A family of seven-transmembrane G protein-coupled receptors; The T cell death associated gene-8 receptor (TDAG8, also known as GPR65) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. Activation of TDAG8 by extracellular acidosis increases the cAMP production, stimulates Rho, and induces stress fiber formation. TDAG8 has also been shown to regulate the extracellular acidosis-induced inhibition of pro-inflammatory cytokine production in peritoneal macrophages.


Pssm-ID: 320487 [Multi-domain]  Cd Length: 277  Bit Score: 48.62  E-value: 1.82e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  81 SMAISDVLVAVlVMPLSLVHELSGRRWQLGRRLCQLWIACDVLCCTASIWNVTAIALDRYWSITRHLEYTLRTRKRVSNV 160
Cdd:cd15365  41 NLSLSDLLYIV-ILPLWIDYLWNGDNWTLSGFVCIFSAFLLYTNFYTSTALLTCIALDRYLAVVHPLKFMHLRTIRTALS 119
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 84370345 161 MILLTWALSTVISLAPLLfgWGETYSEPSEE--CQVSREPS-----YTVFSTVGAFYLPLCVVLFVYWKIYRAAK 228
Cdd:cd15365 120 VSVAIWLLEICFNAVILT--WEDSFHESSSHtlCYDKFPLEdwqarLNLFRICLGYLLPLLIILFCYWKIYQAVR 192
7tmA_NPY6R cd15396
neuropeptide Y receptor type 6, member of the class A family of seven-transmembrane G ...
58-232 2.80e-06

neuropeptide Y receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety.


Pssm-ID: 320518 [Multi-domain]  Cd Length: 293  Bit Score: 48.29  E-value: 2.80e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  58 NLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSGrRWQLGRRLCQLWIACDVLCCTASIWNVTAIAL 137
Cdd:cd15396  18 NLCLITIIKKQKEEHNVTNILIANLSLSDVLVCVMCIPFTAVYTLMD-HWIFGETMCKLTSFVQSVSVSVSIFSLVLIAI 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 138 DRYWSITRHLEYtlrtRKRVSNVM--ILLTWALSTVISLAPLLFGW--GETYSEPSEECQVSRE--------PSYT---V 202
Cdd:cd15396  97 ERYQLIVNPRGW----KPSASHAYwgIVLIWLFSLMISIPFLIFHQltDEPFRNLSSHSDFYKDkvvcieawPSETerlI 172
                       170       180       190
                ....*....|....*....|....*....|...
gi 84370345 203 FST---VGAFYLPLCVVLFVYWKIYRAAKFRMG 232
Cdd:cd15396 173 FTTsllVFQYFVPLGFIFICYLKIFVCLKKRNS 205
7tmA_SKR_NK2R cd16004
substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
49-349 3.27e-06

substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The substance-K receptor (SKR), also known as tachykinin receptor 2 (TACR2) or neurokinin A receptor or NK2R, is a G-protein coupled receptor that specifically binds to neurokinin A. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320670 [Multi-domain]  Cd Length: 285  Bit Score: 47.92  E-value: 3.27e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  49 FLAAATFTWNLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHElSGRRWQLGRRLCQLWIACDVLCCTAS 128
Cdd:cd16004   9 LIVLVAVTGNATVIWIILAHRRMRTVTNYFIVNLALADLSMAAFNTAFNFVYA-SHNDWYFGLEFCRFQNFFPITAMFVS 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 129 IWNVTAIALDRYWSITRHLEYTLRTRKrvSNVMILLTWALSTVISLaPLLFGWGETYSEPSEECQVS--------REPSY 200
Cdd:cd16004  88 IYSMTAIAADRYMAIIHPFKPRLSAGS--TKVVIAGIWLVALALAF-PQCFYSTVTMDQGRTKCIVAwpgdsggkHQLTY 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 201 TVFSTVGAFYLPLCVVLFVYWKIYRaakfrmgsrkTNSVSPVP-EAVEVKNATQhpqmvftvrhatvtfqtegdtwREQK 279
Cdd:cd16004 165 HLAVIVLIYLLPLAVMFVTYSIIGI----------TLWRSAVPgHQAHGAYHRQ----------------------LQAK 212
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 84370345 280 EQRAALMVGILIgVFVLCWFPFFVTELISPL-----CSWDVPAIWKSIFlWLGYSNSFFNPLIYTAFNRSYSSAF 349
Cdd:cd16004 213 KKFVKTMVVVVV-TFAICWLPYHLYFILGSFnediyCQKYIQQVYLAIF-WLAMSSTMYNPIIYCCLNQRFRSGF 285
7tmA_AstC_insect cd15094
somatostatin-like receptor for allatostatin C, member of the class A family of ...
45-349 3.43e-06

somatostatin-like receptor for allatostatin C, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. In Drosophila melanogaster and other insects, a 15-amino-acid peptide named allatostatin C(AstC) binds the somatostatin-like receptors. Two AstC receptors have been identified in Drosophila with strong sequence homology to human somatostatin and opioid receptors.


Pssm-ID: 320222 [Multi-domain]  Cd Length: 282  Bit Score: 47.86  E-value: 3.43e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  45 TLLGFLAAATFTWNLLVLATILKVRTFHRVPHNLVASMAISDVLVaVLVMPLSLVHELSGRrWQLGRRLCQLWIACDVLC 124
Cdd:cd15094   5 VLYGLICIVGLVGNGLVIYVVLRYAKMKTVTNLYILNLAVADECF-LIGLPFLIVTMILKY-WPFGAAMCKIYMVLTSIN 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 125 CTASIWNVTAIALDRYWSITRHLEYTLRTRKRVSNVMILLTWALSTVISLAPLLFG--------------WGETYSEPSE 190
Cdd:cd15094  83 QFTSSFTLTVMSADRYLAVCHPIRSMRYRTPFIAKVVCATTWSISFLVMLPIILYAstvpdsgrysctivWPDSSAVNGQ 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 191 EcqvsrepSYTVFSTVGAFYLPLCVVLFVYWKIYRaakfrmgsrKTNSVSPVPEAVEVKNAtqhpqmvftvrHATVTFqt 270
Cdd:cd15094 163 K-------AFTLYTFLLGFAIPLLLISVFYTLVIL---------RLRTVGPKNKSKEKRRS-----------HRKVTR-- 213
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 271 egdtwreqkeqraalMVGILIGVFVLCWFPFFVTE--LISPLCSWDVPAIWKSIFLW---LGYSNSFFNPLIYTAFNRSY 345
Cdd:cd15094 214 ---------------LVLTVISVYIICWLPYWAFQvhLIFLPPGTDMPKWEILMFLLltvLSYANSMVNPLLYAFLSENF 278

                ....
gi 84370345 346 SSAF 349
Cdd:cd15094 279 RKSF 282
7tmA_V1aR cd15385
vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G ...
44-342 3.53e-06

vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; V1a-type receptor is a G(q/11)-coupled receptor that mediates blood vessel constriction. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320507 [Multi-domain]  Cd Length: 301  Bit Score: 47.89  E-value: 3.53e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  44 LTLLGFLAAATFTWNLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSGRrWQLGRRLCQLWIACDVL 123
Cdd:cd15385   4 IAVLAVIFAVAVIGNSSVLLALYKTKKKASRMHLFIKHLSLADLVVAFFQVLPQLCWDITYR-FYGPDFLCRIVKHLQVL 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 124 CCTASIWNVTAIALDRYWSITRHLEyTLRTRKRVSNVMILLTWALSTVISlAPLLFGWgeTYSEPSEECQVSR------E 197
Cdd:cd15385  83 GMFASTYMLVMMTADRYIAICHPLK-TLQQPTKRSYLMIGSAWALSFILS-TPQYFIF--SLSEIENGSGVYDcwanfiV 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 198 P----SYTVFSTVGAFYLPLCVVL----FVYWKIYRAAKFRMGSRKTNS-VSPVPEAVEVKNatqhpqmVFTVRHATVtf 268
Cdd:cd15385 159 PwgikAYITWITISIFVVPVIILLtcygFICYNIWRNIKCKTRRGLSDNaLKNILLAVCVSS-------VKTISRAKI-- 229
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 269 qtegdtwreqkeqRAALMVGILIGVFVLCWFPFFVTELISplcSWDVPAIWK-------SIFLWLGYSNSFFNPLIYTAF 341
Cdd:cd15385 230 -------------RTVKMTFVIVLAYIVCWAPFFTIQMWS---VWDQNFPWDesentavTITALLASLNSCCNPWIYMFF 293

                .
gi 84370345 342 N 342
Cdd:cd15385 294 S 294
7tmA_LTB4R2 cd15122
leukotriene B4 receptor subtype 2 (LTB4R2 or BLT2), member of the class A family of ...
78-234 4.03e-06

leukotriene B4 receptor subtype 2 (LTB4R2 or BLT2), member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the Gq-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320250 [Multi-domain]  Cd Length: 281  Bit Score: 47.88  E-value: 4.03e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  78 LVASMAISDVlvAVLVMPLSLVHELSGRRWQLGRRLCQlwiACDVLCCT---ASIWNVTAIALDRYWSITR-HLEYTLRT 153
Cdd:cd15122  40 LILNLAVADG--AVLLLTPFFITFLTRKTWPFGQAVCK---AVYYLCCLsmyASIFIIGLMSLDRCLAVTRpYLAQSLRK 114
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 154 RKRVSNVMILLtWALSTVISLAPLLF-------GWGETYSEPSEECQVSREPSYTvFSTVGAFYLPLCVVLFVYWKI--- 223
Cdd:cd15122 115 KALVRKILLAI-WLLALLLALPAFVYrhvwkdeGMNDRICEPCHASRGHAIFHYT-FETLVAFVLPFGVILFSYSVIlvr 192
                       170
                ....*....|.
gi 84370345 224 YRAAKFRMGSR 234
Cdd:cd15122 193 LKGARFRRRAR 203
7tmA_HCAR-like cd14991
hydroxycarboxylic acid receptors and related proteins, member of the class A family of ...
81-338 4.93e-06

hydroxycarboxylic acid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the hydroxycarboxylic acid receptors (HCARs) as well as their closely related receptors, GPR31 and oxoeicosanoid receptor 1 (OXER1). HCARs are members of the class A family of G-protein coupled receptors (GPCRs). HCAR subfamily contain three receptor subtypes: HCAR1, HCAR2, and HCAR3. The endogenous ligand of HCAR1 (also known as lactate receptor 1, GPR104, or GPR81) is L-lactic acid. The endogenous ligands of HCAR2 (also known as niacin receptor 1, GPR109A, nicotinic acid receptor) and HCAR3 (also known as niacin receptor 2, orGPR109B) are 3-hydroxybutyric acid and 3-hydroxyoctanoic acid, respectively. All three HCA receptors are expressed in adipocytes, and are coupled to G(i)-proteins mediating anti-lipolytic effects in fat cells. OXER1 is a receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid, whereas GPR31 is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid (12-S-HETE).


Pssm-ID: 320122 [Multi-domain]  Cd Length: 280  Bit Score: 47.44  E-value: 4.93e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  81 SMAISDVLVAVlVMPLSLVHELSGRRWQLGRRLCQLWIACDVLCCTASIWNVTAIALDRYWSITR-HLEYTLRTRKRVSN 159
Cdd:cd14991  41 NLVLADFLLLI-CLPFRIDYYLRGEHWIFGEAWCRVNLFMLSVNRSASIAFLTAVALDRYFKVVHpHHRVNRMSVKAAAG 119
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 160 VMILLtWALstVISL-APLLFGWGETYSEPSEECQVSREPSYTVFST-------VGAFYLPLCVVLFVYWKIYRAAKFRm 231
Cdd:cd14991 120 VAGLL-WAL--VLLLtLPLLLSTLLTVNSNKSSCHSFSSYTKPSLSIrwhnalfLLEFFLPLGLIVFCSVRIACNLRIR- 195
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 232 gsrktnsvspvpeavevknatqhpqmvftvrhatvtfqteGDTWREQKEQRAALMVGILIGVFVLCWFPFFVTELISPLC 311
Cdd:cd14991 196 ----------------------------------------QSLGKQARVQRAIRLVFLVVIVFVLCFLPSIIAGLLALVF 235
                       250       260       270
                ....*....|....*....|....*....|....
gi 84370345 312 SW-------DVPAIWKSIFLWLGYSNSFFNPLIY 338
Cdd:cd14991 236 KNlgscrclNSVAQLFHISLAFTYLNSALDPVIY 269
7tmA_NMU-R cd15133
neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled ...
58-349 5.14e-06

neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320261 [Multi-domain]  Cd Length: 298  Bit Score: 47.52  E-value: 5.14e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  58 NLLVLATILKVRTFhRVPHNL-VASMAISDVLVAVLVMPLSLVHELSGRRWQLGRRLCQLWIACDVLCCTASIWNVTAIA 136
Cdd:cd15133  18 NVLTCLVIARHKAM-RTPTNYyLFSLAVSDLLVLLLGMPLELYELWQNYPFLLGSGGCYFKTFLFETVCLASILNVTALS 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 137 LDRYWSITRHLEY-TLRTRKRVSNVmILLTWALSTVISL---APLLFGWGETYSEPSEECQVSREPSYTVF----STVGA 208
Cdd:cd15133  97 VERYIAVVHPLAArTCSTRPRVTRV-LGCVWGVSMLCALpntSLHGIKFLGSGVPASAQCTVRKPQAIYNMipqhTGHLF 175
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 209 FYLPLCVVLFVYWKIYRAAKFRMGSRKTNSVSpvPEAVEVKNATQHPQmvftvRHATVTfqtegdtwreqkeqraaLMVG 288
Cdd:cd15133 176 FVLPMAVISVLYLLMALRLARERGLDATGAGS--KIGTRTGQLLQHPR-----TRAQVT-----------------KMLF 231
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 84370345 289 ILIGVFVLCWFPFFVTELI-SPLCSW--DVPAIWKSIFLWLG---YSNSFFNPLIYTAFNRSYSSAF 349
Cdd:cd15133 232 ILVVVFAICWAPFHIDRLMwSFISDWtdNLHEVFQYVHIISGvffYLSSAVNPILYNLMSTRFREMF 298
7tmA_CXCR5 cd15181
CXC chemokine receptor type 5, member of the class A family of seven-transmembrane G ...
42-339 5.20e-06

CXC chemokine receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR5 is a B-cell selective receptor that binds specifically to the homeostatic chemokine CXCL13 and regulates adaptive immunity. The receptor is found on all peripheral blood and tonsillar B cells and is involved in lymphocyte migration (homing) to specific tissues and development of normal lymphoid tissue. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341336 [Multi-domain]  Cd Length: 281  Bit Score: 47.44  E-value: 5.20e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  42 LVLTLLGFLAaatftwNLLVLATILKVRTFHRVPHNLVASMAISDVLVaVLVMPLSLVHELSGrrWQLGRRLCQLWIACD 121
Cdd:cd15181   8 SLVFLLGVVG------NGLVLTILLRRRRSRRTTENYLLHLALADLLL-LLTFPFSVVESIAG--WVFGTFLCKLVGAIH 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 122 VLCCTASIWNVTAIALDRYWSITrHLEYTLRTRKRVS-NVMILLTWALSTVISLAPLLFGWGETYSEPSE-ECQVSRE-- 197
Cdd:cd15181  79 KLNFYCSSLLLACISVDRYLAIV-HAIHSYRHRRLRSvHLTCGSIWLVCFLLSLPNLVFLEVETSTNANRtSCSFHQYgi 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 198 PSYTVFST------VGAFYLPLCVVLFVYWKIYRAakfrmgsrktnsvspvpeaveVKNATQHPQmvftvrhatvtfqte 271
Cdd:cd15181 158 HESNWWLTsrflyhVVGFFLPLLIMGYCYATIVVT---------------------LCQSSRRLQ--------------- 201
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 272 gdtwrEQKEQRAALMVgilIGVFVLCWFPFFVTELISPLCswDVPAIWKSIFL------------WLGYSNSFFNPLIYT 339
Cdd:cd15181 202 -----KQKAIRVAILV---TLVFCLCWLPYNIVIFLDTLD--DLKAVVKNCKLndlldaaitvteSLGFSHCCLNPILYA 271
7tmA_PAR cd15162
protease-activated receptors, member of the class A family of seven-transmembrane G ...
78-226 5.30e-06

protease-activated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes purinergic receptor P2Y8 and protease-activated receptors. P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PAR3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 341328 [Multi-domain]  Cd Length: 280  Bit Score: 47.44  E-value: 5.30e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  78 LVASMAISDVLVAVlVMPLSLVHELSGRRWQLGRRLCQLWIACDVLCCTASIWNVTAIALDRYWSITRHLEYTLRTRKRV 157
Cdd:cd15162  38 YMANLAIADLLLVI-WLPFKIAYHIHGNNWIFGEALCRLVTVAFYGNMYCSILLLTCISIDRYLAIVHPMGHRRLRARRY 116
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 158 SNVMILLTWALstVISLAPLLFGWGETYSEP-----------SEECQVSREPSYTVFSTVGAFYLPLCVVLFVYWKIYRA 226
Cdd:cd15162 117 ALGTCLAIWLL--ALLVTLPLYLVKQTIFLPaldittchdvlPEQLLVGDWFYYFLSLAIVGFLIPFILTASCYVATIRT 194
7tmA_CCK-BR cd15979
cholecystokinin receptor type B, member of the class A family of seven-transmembrane G ...
58-349 7.39e-06

cholecystokinin receptor type B, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320645 [Multi-domain]  Cd Length: 275  Bit Score: 47.12  E-value: 7.39e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  58 NLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSGrRWQLGRRLCQLWIACDVLCCTASIWNVTAIAL 137
Cdd:cd15979  18 NMLIIVVLGLNKRLRTVTNSFLLSLALSDLMLAVFCMPFTLIPNLMG-TFIFGEVICKAVAYLMGVSVSVSTFSLVAIAI 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 138 DRYWSITRHLEYTL-RTRKRVSNVmILLTWALSTVISLAPLLFGWGETYSEPS----EECqVSREPSYTVFStvgAFYLP 212
Cdd:cd15979  97 ERYSAICNPLQSRVwQTRSHAYRV-IAATWLLSGLIMIPYPVYSVTVPVPVGDrprgHQC-RHAWPSAQVRQ---AWYVL 171
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 213 LCVVLFVYwkiyraakfrmgsrktnsvspvpeavevknatqhPQMVFTVRHATVTfqtegdtwRE-----QKEQRAALMV 287
Cdd:cd15979 172 LLLILFFI----------------------------------PGVVMIVAYGLIS--------RElyrglLAKKRVIRML 209
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 84370345 288 GILIGVFVLCWFPFFVTELISplcSWDVPAIWK-------SIFLWLGYSNSFFNPLIYTAFNRSYSSAF 349
Cdd:cd15979 210 VVIVAMFFLCWLPIFSANTWR---AFDPLSAHRalsgapiSFIHLLSYTSACVNPLVYCFMNRRFRKAF 275
7tmA_ACKR3_CXCR7 cd14987
CXC chemokine receptor 7, member of the class A family of seven-transmembrane G ...
58-226 8.24e-06

CXC chemokine receptor 7, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR3, also known as CXCR7, is an atypical chemokine receptor for CXCL12 and CXCR11. Unlike the classical chemokine receptors, ACKR3 contains a DRYLSIT-sequence instead of the conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. Thus, ACKR3 does not activate classical GPCR signaling, instead induces beta-arrestin recruitment which is leading to ligand internalization and MAP-kinase activation. It is acting as a scavenger for CXCL12 and, to a lesser degree, for CXCL11. ACKR3 is highly expressed by blood vascular endothelial cells in brain, in numerous embryonic and neonatal tissues, in inflamed tissues and in a variety of cancers such as lymphomas, sarcomas, prostate and breast cancers, and gliomas. Five receptors have been identified for the ACKR family, including CC-Chemokine Receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, DARC, and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320118 [Multi-domain]  Cd Length: 282  Bit Score: 46.67  E-value: 8.24e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  58 NLLVLATILKVRTFHRVPHNLVASMAISDVLVaVLVMPLSLVHELSGRRWQLGRRLCQLWIACDVLCCTASIWNVTAIAL 137
Cdd:cd14987  18 NSVVVWVNLQAKRTGYETHLYILNLAIADLCV-VATLPVWVVSLVQHNQWPMGEFTCKITHLIFSINLFGSIFFLTCMSV 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 138 DRYWSITRHLEYTLRTRKRVSNVMILLTWALSTVISLAPLLF-------GWGETYSEPSEECQVSRE--PSYTVFSTVGA 208
Cdd:cd14987  97 DRYLSVTLFGNTSSRRKKIVRRIICVLVWLLAFVASLPDTYFlktvtspSNNETYCRSFYPEESFKEwlIGMELVSIVLG 176
                       170
                ....*....|....*...
gi 84370345 209 FYLPLCVVLFVYWKIYRA 226
Cdd:cd14987 177 FVIPFPIIAVFYFLLARA 194
7tmA_NPBWR cd15087
neuropeptide B/W receptors, member of the class A family of seven-transmembrane G ...
52-349 9.48e-06

neuropeptide B/W receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide B/W receptor 1 and 2 are members of the class A G-protein coupled receptors that bind the neuropeptides B and W, respectively. NPBWR1 (previously known as GPR7) is expressed predominantly in cerebellum and frontal cortex, while NPBWR2 (previously known as GPR8) is located mostly in the frontal cortex and is present in human, but not in rat and mice. These receptors are suggested to be involved in the regulation of food intake, neuroendocrine function, and modulation of inflammatory pain, among many others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320215 [Multi-domain]  Cd Length: 282  Bit Score: 46.66  E-value: 9.48e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  52 AATFTWNLLVLATILKVRTFHRVPHNLVASMAISDVLVaVLVMPLSLVHELSgRRWQLGRRLCQLWIACDVLCCTASIWN 131
Cdd:cd15087  12 AVGLTGNTAVIYVILRAPKMKTVTNVFILNLAIADDLF-TLVLPINIAEHLL-QQWPFGELLCKLILSIDHYNIFSSIYF 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 132 VTAIALDRYWSI-----TRHLEY-TLRTRKRVSnvmiLLTWALSTVISLAPLLFG------WGET---YSEPSEEC---Q 193
Cdd:cd15087  90 LTVMSVDRYLVVlatvrSRRMPYrTYRAAKIVS----LCVWLLVTIIVLPFTVFAgvysneLGRKscvLSFPSPESlwfK 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 194 VSRepsytVFSTVGAFYLPLCVVLFVYwkIYRAAKFRMGSRKTNSVSpvpeavevknatqhpqmvftvrhatvtfqtegd 273
Cdd:cd15087 166 ASR-----IYTLVLGFAIPVSTICILY--TMMLYKLRNMRLNSNAKA--------------------------------- 205
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 274 twREQKEQRAALMVGILIGVFVLCWFPFFVTELISplCSWDVP----AIWKSIFLW-LGYSNSFFNPLIYTAFNRSYSSA 348
Cdd:cd15087 206 --LDKAKKKVTLMVLVVLAVCLFCWTPFHLSTVVA--LTTDLPqtplVIGISYFITsLSYANSCLNPFLYAFLDDSFRKS 281

                .
gi 84370345 349 F 349
Cdd:cd15087 282 F 282
7tmA_NK1R cd16002
neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled ...
127-349 1.36e-05

neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neurokinin 1 receptor (NK1R), also known as tachykinin receptor 1 (TACR1) or substance P receptor (SPR), is a G-protein coupled receptor found in the mammalian central nervous and peripheral nervous systems. The tachykinins act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. SP is an extremely potent vasodilator through endothelium dependent mechanism and is released from the autonomic sensory nerves. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320668 [Multi-domain]  Cd Length: 284  Bit Score: 46.01  E-value: 1.36e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 127 ASIWNVTAIALDRYWSITRHLEYtlRTRKRVSNVMILLTWALStvISLAPLLFGWGETYSEPS---------EECQVSRE 197
Cdd:cd16002  86 ASIYSMTAIALDRYMAIIHPLQP--RLSATATKVVICVIWVLA--FLLAFPQGYYSDTEEMPGrvvcyvewpEHEERKYE 161
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 198 PSYTVFSTVGAFYLPLCVVLFVYWKIyraakfrmgsRKTNSVSPVPeavevknatqhpqmvftvrhatvtfQTEGDTWRE 277
Cdd:cd16002 162 TVYHVCVTVLIYFLPLLVIGCAYTVV----------GITLWASEIP-------------------------GDSSDRYHE 206
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 84370345 278 QKEQRAAL--MVGILIGVFVLCWFPFFVTELISPLC-SWDVPAIWKSIFL---WLGYSNSFFNPLIYTAFNRSYSSAF 349
Cdd:cd16002 207 QVSAKRKVvkMMIVVVCTFAICWLPYHIYFLLQYFHpELYEQKFIQQVYLaimWLAMSSTMYNPIIYCCLNDRFRVGF 284
7tmA_MC3R cd15352
melanocortin receptor subtype 3, member of the class A family of seven-transmembrane G ...
58-338 1.53e-05

melanocortin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320474 [Multi-domain]  Cd Length: 272  Bit Score: 46.04  E-value: 1.53e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  58 NLLVLATILKVRTFHRVPHNLVASMAISDVLVAVL-VMPLSLVHELSGRRWQLGRRLCQLWI-ACDVLCC---TASIWNV 132
Cdd:cd15352  18 NILVILAVVKNKNLHSPMYFFLCSLAVADMLVSVSnSLETIMIAVLNSGYLVISDQFIQHMDnVFDSMICislVASICNL 97
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 133 TAIALDRYWSITRHLEYTLRTRKRVSNVMILLTWALSTVISLAPLLFGwgetysepseecqvsrEPSYTVFSTVGAFYLP 212
Cdd:cd15352  98 LAIAVDRYVTIFYALRYHSIMTVRKALVLIAVIWVVCIVCGIVFIVYS----------------ESKTVIVCLITMFFAM 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 213 LCVVLFVYWKIYRAAKFRMgsrktNSVSPVPEAVEVKnATQHPQMvftvrhatvtfqtegdtwreqkeqRAALMVGILIG 292
Cdd:cd15352 162 LVLMATLYVHMFLFARLHV-----KRIAALPPAVDGA-PQQRSCM------------------------KGAVTITILLG 211
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 84370345 293 VFVLCWFPFFVTELISPLCSWDVPAI----WKSIFLWLGYSNSFFNPLIY 338
Cdd:cd15352 212 VFIVCWAPFFLHLILIISCPHNPYCLcytsHFNTYLVLIMCNSVIDPLIY 261
7tmA_GPR33 cd15120
orphan receptor GPR33, member of the class A family of seven-transmembrane G protein-coupled ...
84-179 1.55e-05

orphan receptor GPR33, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor GPR33, an orphan member of the chemokine-like receptor family, was originally identified as a pseudogene in humans as well as in several apes and rodent species. Although the intact GPR33 allele is still present in a small fraction of the human population, the human GPR33 contains a premature stop codon. The amino acid sequence of GPR33 shares a high degree of sequence identity with the members of the chemokine and chemoattractant receptors that control leukocyte chemotaxis. The human GPR33 is expressed in spleen, lung, heart, kidney, pancreas, thymus, gonads, and leukocytes.


Pssm-ID: 320248 [Multi-domain]  Cd Length: 282  Bit Score: 45.93  E-value: 1.55e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  84 ISDVLVAVLVMPLSLVHELSGRRWQLGRRLCQLWIACDVLCCTASIWNVTAIALDRYWSITRHLEYTLRTRKRVSNVMIL 163
Cdd:cd15120  42 ILSNLIFTLILPFMAVHVLMDNHWAFGTVLCKVLNSTLSVGMFTSVFLLTAISLDRYLLTLHPVWSRQHRTNRWASAIVL 121
                        90
                ....*....|....*.
gi 84370345 164 LTWALSTVISLAPLLF 179
Cdd:cd15120 122 GVWISAILLSIPYLAF 137
7tmA_C3aR cd15115
complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of ...
82-338 1.68e-05

complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The anaphylatoxin receptors are a group of G-protein coupled receptors which bind anaphylatoxins; members of this group include C3a receptors and C5a receptors. Anaphylatoxins are also known as complement peptides (C3a, C4a and C5a) that are produced from the activation of the complement system cascade. These complement anaphylatoxins can trigger degranulation of endothelial cells, mast cells, or phagocytes, which induce a local inflammatory response and stimulate smooth muscle cell contraction, histamine release, and increased vascular permeability. They are potent mediators involved in chemotaxis, inflammation, and generation of cytotoxic oxygen-derived free radicals. In humans, a single receptor for C3a (C3AR1) and two receptors for C5a (C5AR1 and C5AR2, also known as C5L2 or GPR77) have been identified, but there is no known receptor for C4a.


Pssm-ID: 320243 [Multi-domain]  Cd Length: 265  Bit Score: 45.92  E-value: 1.68e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  82 MAISDvLVAVLVMPLSLVHELSGRRWQLGRRLCQLWIACDVLCCTASIWNVTAIALDRYWSITRHLEYTLRTRKRVSNVM 161
Cdd:cd15115  41 LAVAD-LLCCLSLPFSIAHLLLNGHWPYGRFLCKLLPSIIVLNMFASVFTLTAISLDRFLLVIKPVWAQNHRSVLLACLL 119
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 162 ILLTWALSTVISLAplLFGWGETYSEPSE-ECQVSREPSYTVFSTVGAFYLPLCVVLFVYWKIYRaaKFRMGSRKtnsvs 240
Cdd:cd15115 120 CGCIWILALLLCLP--VFIYRTTVTDGNHtRCGYDFLVAITITRAVFGFLLPLLIIAACYSFIAF--RMQRGRFA----- 190
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 241 pvpeavevknatqhpqmvftvrhatvtfqtegdtwreQKEQRAALMVGILIGVFVLCWFPFFVTELISplcSWDVPAIWK 320
Cdd:cd15115 191 -------------------------------------KSQSKTFRVIIAVVVAFFVCWAPYHIIGILS---LYGDPPLSK 230
                       250       260
                ....*....|....*....|....
gi 84370345 321 SIFLW------LGYSNSFFNPLIY 338
Cdd:cd15115 231 VLMSWdhlsiaLAYANSCLNPVLY 254
7tmA_SREB1_GPR27 cd15216
super conserved receptor expressed in brain 1 (or GPR27), member of the class A family of ...
42-349 1.74e-05

super conserved receptor expressed in brain 1 (or GPR27), member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320344 [Multi-domain]  Cd Length: 332  Bit Score: 46.17  E-value: 1.74e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  42 LVLTLLGFLAAATFTWNLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLvheLSGRRWQL------GRRLCQ 115
Cdd:cd15216   2 LRLATLSLLLCVSLAGNVLFALLIVRERSLHRAPYYLLLDLCLADGLRALACLPAVM---LAARRAAAaagtppGALGCK 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 116 LWIACDVLCCTASIWNVTAIALDRYWSITRHLEYTLRTRK-RVSNVMILLTWALSTVISLAPLL-FGWGETYSEPseeCQ 193
Cdd:cd15216  79 LLAFLAALFCFHAAFLLLGVGVTRYLAIAHHRFYAERLAGwPCAAMLVCAAWALALAAAFPPVLdGGGADDEDAP---CA 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 194 VSREPSYTVFSTvgAFYLPLCVVLFVYWKIY-RAAKFRMGSRKTNSVSPVPE-----AVEVKNATQHPQMVFTVRH---- 263
Cdd:cd15216 156 LEQRPDGAPGAL--GFLLLLAAVVGATHLVYlRLLFFIHDRRKMRPARLVPAvshdwTFHGPGATGQAAANWTAGFgrgp 233
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 264 ---ATVTFQTEGDTWREQK---------EQRAALMVGILIGVFVLCWFPFFVTELISPLCS-WDVPAIWKSIFLWLGYSN 330
Cdd:cd15216 234 tppALVGIRPAGPGRGARRllvleefktEKRLCKMFYAITLLFLLLWGPYVVASYLRVLVRpGAVPQAYLTASVWLTFAQ 313
                       330
                ....*....|....*....
gi 84370345 331 SFFNPLIYTAFNRSYSSAF 349
Cdd:cd15216 314 AGINPVVCFLFNRELRDCF 332
7tmA_GPR88-like cd15211
G protein-coupled receptor 88, member of the class A family of seven-transmembrane G ...
42-349 1.77e-05

G protein-coupled receptor 88, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR88, an orphan G protein-coupled receptor, is predominantly and almost exclusively expressed within medium spiny neurons (MSNs) of the brain's striatum in both human and rodents; thus it is also called Striatum-specific GPCR (STRG). The striatum is known to involve in motor coordination, reward-based decision making, and response learning. GPR88 is shown to co-localize with both dopamine D1 and D2 receptors and displays the highest sequence similarity to receptors for biogenic amines such as dopamine and serotonin. GPR88 knockout mice showed abnormal behaviors observed in schizophrenia, such as disrupted sensorimotor gating, increased stereotypic behavior and locomotor activity in response to treatment with dopaminergic compounds such as apomorphine and amphetamine, respectively, suggesting a role for GPR88 in dopaminergic signaling. Furthermore, the transcriptional profiling studies showed that GPR88 expression is altered in a number of psychiatric disorders such as depression, drug addiction, bipolar and schizophrenia, providing further evidence that GPR88 plays an important role in CNS signaling pathways related to psychiatric disorder. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320339 [Multi-domain]  Cd Length: 283  Bit Score: 46.00  E-value: 1.77e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  42 LVLTLLGFLAAATFTWNLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSGRRWQLGRRLcqLWIACD 121
Cdd:cd15211   1 SLSTVYSFLAVSGTLANVLVIYLVVSFKKLQTTSNAFIVNGCVADLLVCAFWMPQEAVLGSTGTLLVLGYRL--FREGLL 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 122 VLCCTASIWNVTAIALDRYWSITRHLE-YTLRTRKRVSNVMILLTWALStVISLAPLLFGWgetySEPSEECQVSREPSY 200
Cdd:cd15211  79 FLGLTVSLLSHSLIALNRYVLITKLPAvYQALYQKRNTEWMIALSWALA-LGLLLPWLTSF----RYPTKSCHDSADGSF 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 201 TVFSTVGAFYLPL----------CVVLFVYWKIYRAAKfrmGSRKTNSVSPVPeaveVKNATQHPqmvftvrhatvtfqt 270
Cdd:cd15211 154 AVVSVLSSRYPALllaftvlgqtALVLHCYFGIFRRVQ---ISVKRVSVLNFQ----IVNNLPYS--------------- 211
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 84370345 271 egdtwREQKEQRAALMVGILIGVFVLCWFPFFVTELISpLCSWDVPAIWKSIFLwLGYSNSFFNPLIYTAFNRSYSSAF 349
Cdd:cd15211 212 -----RPRKDKRLGLYVLLVCCVFLLTTEPLVWVSLAG-LFVPVPVALQTASWL-LFCTLFVLNPFLYTWKNEEFRRSF 283
7tmA_Proton-sensing_R cd15160
proton-sensing G protein-coupled receptors, member of the class A family of ...
79-235 1.96e-05

proton-sensing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Proton/pH-sensing G-protein coupled receptors sense pH of 7.6 to 6.0. They mediate a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. The proton/pH-sensing receptor family includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 (TDAG8, GPR65) receptor, ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4).


Pssm-ID: 320288 [Multi-domain]  Cd Length: 280  Bit Score: 45.84  E-value: 1.96e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  79 VASMAISDvLVAVLVMPLSLVHELSGRRWQLGRRLCQLWIACDVLCCTASIWNVTAIALDRYWSITRHLEY-TLRTRKrv 157
Cdd:cd15160  39 LLNLSLSD-LLYILTLPLWIDYTANHHNWTFGPLSCKVVGFFFYTNIYASIGFLCCIAVDRYLAVVHPLRFrGLRTRR-- 115
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 158 SNVMILLT-WALSTVISLAPLlfgWGETYSEPSEECQV--------SREPSYTVFSTVGAFYLPLCVVLFVYWKIYRAAK 228
Cdd:cd15160 116 FALKVSASiWVLELGTHSVFL---GHDELFRDEPNHTLcyekypmeGWQASYNYARFLVGFLIPLSLILFFYRRVLRAVR 192

                ....*..
gi 84370345 229 FRMGSRK 235
Cdd:cd15160 193 QSPSLER 199
7tmA_P2Y11 cd15376
P2Y purinoceptor 11, member of the class A family of seven-transmembrane G protein-coupled ...
80-226 2.43e-05

P2Y purinoceptor 11, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y11 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. The activation of P2Y11 is a major pathway of macrophage activation that leads to the release of cytokines. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320498 [Multi-domain]  Cd Length: 284  Bit Score: 45.46  E-value: 2.43e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  80 ASMAISDVLVAvLVMPLSLVHELSGRRWQLGRRLCQL---WIACDVLcctASIWNVTAIALDRYWSITRHLEYTLRTRKR 156
Cdd:cd15376  41 FNLAVSDLLYA-LSLPLLAAYYYPPKNWRFGEAACKLerfLFTCNLY---GSIFFITCISLNRYLGIVHPFFTRSHVRPK 116
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 84370345 157 VSNVMILLTWALSTVISLAPLLFGWGETYSEPSEEC----QVSREPSYTVFSTVGAFY---LPLCVVLFVYWKIYRA 226
Cdd:cd15376 117 HAKLVSLAVWLLVAALSAPVLSFSHLEVERHNKTEClgtaVDSRLPTYLPYSLFLAVVgcgLPFLLTLASYLAIVWA 193
7tmA_GRPR cd15124
gastrin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
43-349 2.46e-05

gastrin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The gastrin-releasing peptide receptor (GRPR) is a G-protein coupled receptor whose endogenous ligand is gastrin releasing peptide. GRP shares high sequence homology with the neuropeptide neuromedin B in the C-terminal region. This receptor is high glycosylated and couples to a pertussis-toxin-insensitive G protein of the family of Gq/11, which leads to the activation of phospholipase C. Gastrin-releasing peptide (GRP) is a potent mitogen for neoplastic tissues and involved in regulating multiple functions of the gastrointestinal and central nervous systems. These include the release of gastrointestinal hormones, the contraction of smooth muscle cells, and the proliferation of epithelial cells. GRPR belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin.


Pssm-ID: 320252 [Multi-domain]  Cd Length: 293  Bit Score: 45.28  E-value: 2.46e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  43 VLTLLGFLAaatftwNLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSgRRWQLGRRLCQLWIACDV 122
Cdd:cd15124   9 IIILIGLIG------NITLIKIFCTVKSMRNVPNLFISSLALGDLLLLVTCAPVDASRYLA-DEWLFGRVGCKLIPFIQL 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 123 LCCTASIWNVTAIALDRYWSITRHLEYTLRTRKRVSNVMILLTWALSTVISLAPLLFGWGETYSEPS-EECQVSREPS-- 199
Cdd:cd15124  82 TSVGVSVFTLTALSADRYKAIVRPMDIQASNALMKICLKAALIWILSMLLAIPEAVFSDLHPFYDKStNKTFVSCAPYph 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 200 --------YTVFSTVGAFYLPLCVVLFVYWKIyraAKFRMGSRKTnsvSPVPEAVEVKNATqhpqmvftvrhatvtfqte 271
Cdd:cd15124 162 snelhpkiHSMASFLIFYVIPLSIISVYYYFI---AKNLIRSAYN---LPVEGNVHVRRQI------------------- 216
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 272 gdtwreQKEQRAALMVGILIGVFVLCWFPFFVTELISPLCSWDVPA-----IWKSIFLWLGYSNSFFNPLIYTAFNRSYS 346
Cdd:cd15124 217 ------ESRKRLAKTVLVFVGLFAFCWLPNHIIYLYRSYHYSEVDTsmlhfVSSICARILAFTNSCVNPFALYLLSKSFR 290

                ...
gi 84370345 347 SAF 349
Cdd:cd15124 291 KQF 293
7tmA_Bombesin_R-like cd15927
bombesin receptor subfamily, member of the class A family of seven-transmembrane G ...
58-336 2.78e-05

bombesin receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This bombesin subfamily of G-protein coupled receptors consists of neuromedin B receptor (NMBR), gastrin-releasing peptide receptor (GRPR), and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple mainly to the G proteins of G(q/11) family. NMBR functions as the receptor for the neuropeptide neuromedin B, a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. Gastrin-releasing peptide is an endogenous ligand for GRPR and shares high sequence homology with NMB in the C-terminal region. Both NMB and GRP possess bombesin-like biochemical properties. BRS-3 is classified as an orphan receptor and suggested to play a role in sperm cell division and maturation. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. The bombesin receptor family belongs to the seven transmembrane rhodopsin-like G-protein coupled receptors (class A GPCRs), which perceive extracellular signals and transduce them to guanine nucleotide-binding (G) proteins.


Pssm-ID: 320593 [Multi-domain]  Cd Length: 294  Bit Score: 45.34  E-value: 2.78e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  58 NLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSgRRWQLGRRLCQLWIACDVLCCTASIWNVTAIAL 137
Cdd:cd15927  18 NGTLILIFLRNKSMRNVPNIFILSLALGDLLLLLTCVPFTSTIYTL-DSWPFGEFLCKLSEFLKDTSIGVSVFTLTALSA 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 138 DRYWSITRHLEYTLRTRKRVSNVMILLTWALSTVISLAPLLFGWGETYSEPSEE----CQ---VSREPSYTVFSTVGAFY 210
Cdd:cd15927  97 DRYFAIVNPMRKHRSQATRRTLVTAASIWIVSILLAIPEAIFSHVVTFTLTDNQtiqiCYpypQELGPNYPKIMVLLRFL 176
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 211 ----LPLCVVLFVYWKIYRAAkfrmgsrktnsvspvpeaveVKNATQHPQMvftvrhatvtfqtEGDTWREQKEQR--AA 284
Cdd:cd15927 177 vyylIPLLIIGVFYVLMARHL--------------------IRSTRNIGSG-------------QNQAAQRQIEARkkVA 223
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 84370345 285 LMVGILIGVFVLCWFPFFVTEL---ISPLCSWDVPA---IWKSIFLWLGYSNSFFNPL 336
Cdd:cd15927 224 KTVLAFVVLFAVCWLPRHVFMLwfhFAPNGLVDYNAfwhVLKIVGFCLSFINSCVNPV 281
7tmA_GPR1 cd15119
G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane ...
82-179 3.54e-05

G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 1 (GPR1) belongs to the class A of the seven transmembrane domain receptors. This is an orphan receptor that can be activated by the leukocyte chemoattractant chemerin, thereby suggesting that some of the anti-inflammatory actions of chemerin may be mediated through GPR1. GPR1 is most closely related to another chemerin receptor CMKLR1. In an in-vitro study, GPR1 has been shown to act as a co-receptor to allow replication of HIV viruses.


Pssm-ID: 320247 [Multi-domain]  Cd Length: 278  Bit Score: 44.73  E-value: 3.54e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  82 MAISDvLVAVLVMPLSLVHELSGRRWQLGRRLCQLWIACDVLCCTASIWNVTAIALDRYWSITR-HLEYTLRTRKRvSNV 160
Cdd:cd15119  41 LAIAD-FVFVLFLPLHITYVALDFHWPFGVWLCKINSFVAVLNMFASVLFLTVISLDRYISLAHpVWSHRYRTLKS-ALI 118
                        90
                ....*....|....*....
gi 84370345 161 MILLTWALSTVISLAPLLF 179
Cdd:cd15119 119 LCGIVWLSAAAISGPALYF 137
7tmA_OT_R cd15387
oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
41-341 3.97e-05

oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Oxytocin is a peptide of nine amino acids synthesized in the hypothalamus and is released from the posterior pituitary gland. Oxytocin plays an important role in sexual reproduction of both sexes and is structurally very similar to vasopressin. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320509 [Multi-domain]  Cd Length: 297  Bit Score: 44.81  E-value: 3.97e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  41 VLVLTLLGFLAaatFTWNLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSGRRWQlGRRLCQLWIAC 120
Cdd:cd15387   4 VTVLALILFLA---LTGNICVLLAIHTTRHKHSRMYFFMKHLSIADLVVAVFQVLPQLIWDITFRFYG-PDFLCRLVKYL 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 121 DVLCCTASIWNVTAIALDRYWSITRHLEytlRTRKRVSNVMILLTWALSTVISLAPL-LFGWGETYSEPSEECQVSREP- 198
Cdd:cd15387  80 QVVGMFASTYMLLLMSIDRCLAICQPLR---SLHRRSDRVYVLFSWLLSLVFSIPQVhIFSLREVGNGVYDCWADFIQPw 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 199 ---SYTVFSTVGAFYLPLCVVLFVY----WKIYRAAKFRMgsrKTNSVSPVPEAVEVKNATQHPQMVFTVRHATVtfqte 271
Cdd:cd15387 157 gpkAYITWITLSVYIIPVLILSVCYglisFKIWQNVKLKT---RRETKTPLSSAASGGAALARVSSVKLISKAKI----- 228
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 84370345 272 gdtwreqkeqRAALMVGILIGVFVLCWFPFFVTELISplcSWDVPAIWKS----IFLWLGYSNSFFNPLIYTAF 341
Cdd:cd15387 229 ----------RTVKMTFVIVLAYIVCWTPFFFVQMWS---VWDPNAPKEAspfiIAMLLASLNSCCNPWIYMFF 289
7tmA_GPR63 cd15404
G protein-coupled receptor 63, member of the class A family of seven-transmembrane G ...
49-338 4.60e-05

G protein-coupled receptor 63, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the human orphan receptor GPR63, which is also called PSP24-beta or PSP24-2, and its closely related proteins found in vertebrates. GPR63 shares the highest sequence homology with GPR45 (Xenopus PSP24, mammalian PSP24-alpha or PSP24-1). PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Mammalian PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320526 [Multi-domain]  Cd Length: 265  Bit Score: 44.44  E-value: 4.60e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  49 FLAAATFTWNLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSgRRWQLGRRLCQLWIACDVLCCTAS 128
Cdd:cd15404   9 FILLVSFLGNFVVCLMVYQKAAMRSAINILLASLAFADMMLAVLNMPFALVTIIT-TRWIFGDAFCRVSAMFFWLFVMEG 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 129 IWNVTAIALDRYWSITRHLEYTLRTRKRvsnVMILLTWALSTVISLaPLLFGWGETYSEPSEECQV---SREP---SYTV 202
Cdd:cd15404  88 VAILLIISIDRFLIIVQKQDKLNPYRAK---VLIAVSWAVSFCVAF-PLAVGSPDLQIPSRAPQCVfgyTTNPgyqAYVI 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 203 FSTVGAFYLPLCVVLFVYWKIYRaakfrmgsrktnsvspvpeavevknatqhpqmvfTVRhatvTFQTegdtwreqkeqR 282
Cdd:cd15404 164 LIMLIFFFIPFMVMLYSFMGILN----------------------------------TVR----SFKT-----------R 194
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 283 AALMVGILIGVFVLCWFPFFVTELISPLCS--WDVPAIWK--SIFLWLGYSNSFFNPLIY 338
Cdd:cd15404 195 AFTTILILFIVFTVCWAPFTTYSLVATFNShfYHKHNFFEisTWLLWLCYLKSALNPLIY 254
7tmA_MC1R cd15351
melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G ...
49-338 4.93e-05

melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320473 [Multi-domain]  Cd Length: 271  Bit Score: 44.40  E-value: 4.93e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  49 FLAAATFTWNLLVLATILKVRTFHRVPHNLVASMAISDVLVAV------LVMPLsLVHELSGRRWQLGRRLCQLwiaCDV 122
Cdd:cd15351   9 FLGLVSLVENILVVVAIAKNRNLHSPMYYFICCLAVSDMLVSVsnlietLFMLL-LEHGVLVCRAPMLQHMDNV---IDT 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 123 LCCTA---SIWNVTAIALDRYWSITRHLEY-TLRTRKRVSNVmILLTWALSTVISLAPLLFgwgetysepseecqvsREP 198
Cdd:cd15351  85 MICSSvvsSLSFLGAIAVDRYITIFYALRYhSIMTLQRAVNA-IAGIWLASTVSSTLFIVY----------------YNS 147
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 199 SYTVFSTVGAFYLPLCVVLFVYWKIYRAAKfrmgsrktnsvspvpeavevknatQHPQMVftvrhatVTFQTEGDTWREQ 278
Cdd:cd15351 148 NAVILCLIVFFLFMLVLMLVLYIHMFILAC------------------------RHSQSI-------SSQQRRQCPHQQT 196
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 84370345 279 KEQRAALMVGILIGVFVLCWFPFF------VTELISPLCSwdvpAIWK--SIFLWLGYSNSFFNPLIY 338
Cdd:cd15351 197 ASLKGAITLTILLGIFFLCWGPFFlhltliVTCPTHPFCL----CYFKyfNLFLILIICNSIIDPLIY 260
7tmA_P2Y1-like cd15967
P2Y purinoceptor 1-like; P2Y1-like is an uncharacterized group that is phylogenetically ...
78-220 7.24e-05

P2Y purinoceptor 1-like; P2Y1-like is an uncharacterized group that is phylogenetically related to a family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320633 [Multi-domain]  Cd Length: 281  Bit Score: 43.91  E-value: 7.24e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  78 LVASMAISDVLVaVLVMPLSLVHELSGRRWQLGRRLCQLWIACDVLCCTASIWNVTAIALDRYWSITRHLEYTLRTRKRV 157
Cdd:cd15967  38 FVLNLGLADLLY-LLTLPFLVVYYLKGRKWIFGQVFCKITRFCFNLNLYGSIGFLTCISVYRYLAIVHPMRVMGRITTTH 116
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 158 SNVMILLTWALsTVISLAPLLFgWGETYSEPsEECQVSRE----PSYTVFS---TVGAFYLPLCVVLFVY 220
Cdd:cd15967 117 SVVISALVWLL-VVIQSLPDLF-FSKTNSNG-TKCFDTTFndylESYLTYSlgwTVTGFVIPLLIILGCY 183
7tmA_NPSR cd15197
neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled ...
44-349 7.27e-05

neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR is widely expressed in the brain, and its activation induces an elevation of intracellular calcium and cAMP concentrations, presumably by coupling to G(s) and G(q) proteins. Mutations in NPSR have been associated with an increased susceptibility to asthma. NPSR was originally identified as an orphan receptor GPR154 and is also known as G protein receptor for asthma susceptibility (GPRA) or vasopressin receptor-related receptor 1 (VRR1).


Pssm-ID: 320325 [Multi-domain]  Cd Length: 294  Bit Score: 43.95  E-value: 7.27e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  44 LTLLGFLAAATFTWNLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSGRrWQLGRRLCQLWIACDVL 123
Cdd:cd15197   4 LATLWVLFVFIVVGNSSVLFALWMRKAKKSRMNFFITQLAIADLCVGLINVLTDIIWRITVE-WRAGDFACKVIRYLQVV 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 124 CCTASIWNVTAIALDRYWSITRHLEYtLRTRKRvSNVMILLTWALSTVISLAPLLFGWGETYSEPSEECQVS-REPSYT- 201
Cdd:cd15197  83 VTYASTYVLVALSIDRYDAICHPMNF-SQSGRQ-ARVLICVAWILSALFSIPMLIIFEKTGLSNGEVQCWILwPEPWYWk 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 202 VFSTVGA---FYLPLCVVlfvywkiyraakfrmgsrktnsvspvpeavevknATQHPQMVFTVRHATVTFQTEGDTWREQ 278
Cdd:cd15197 161 VYMTIVAflvFFIPATII----------------------------------SICYIIIVRTIWKKSKIQVTINKAGLHD 206
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 279 KEQRAALMVGIL--------------IGVFVLCWFPFFVTELISPLCswDVP----AIWKSIFLW-LGYSNSFFNPLIYT 339
Cdd:cd15197 207 GSSRRSSSRGIIprakiktikmtfviVTVFIICWSPYFVFDLLDVFG--LLPrsktKIAAATFIQsLAPLNSAINPLIYC 284
                       330
                ....*....|
gi 84370345 340 AFNRSYSSAF 349
Cdd:cd15197 285 LFSTHLCRPL 294
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
82-350 7.28e-05

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 44.00  E-value: 7.28e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345   82 MAISDvLVAVLVMPLSLVHELSgRRWQLGRRLCQLWIACDVLCCTASIWNVTAIALDRYWSITRHLEYTLRTRKRVSNVM 161
Cdd:PHA03087  81 LAVSD-LLFVMTLPFQIYYYIL-FQWSFGEFACKIVSGLYYIGFYNSMNFITVMSVDRYIAIVHPVKSNKINTVKYGYIV 158
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  162 ILLTWALSTVISLaPLLFGWGETYSEPSEECQVSRE-------PSYTVFSTVGAFYLPLCVVLFVYWKIYRAAKfrmGSR 234
Cdd:PHA03087 159 SLVIWIISIIETT-PILFVYTTKKDHETLICCMFYNnktmnwkLFINFEINIIGMLIPLTILLYCYSKILITLK---GIN 234
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  235 KTNsvspvpeavevknatqhpqmvftvrhatvtfqtegdtwreqKEQRAALMVGILIGVFVLCWFPFFVTELISPLCSW- 313
Cdd:PHA03087 235 KSK-----------------------------------------KNKKAIKLVLIIVILFVIFWLPFNVSVFVYSLHILh 273
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 84370345  314 ------DVPAIWKSIFL--WLGYSNSFFNPLIYTAFNRSYSSAFK 350
Cdd:PHA03087 274 fksgckAVKYIQYALHVteIISLSHCCINPLIYAFVSEFFNKHKK 318
7tmA_BRS-3 cd15123
bombesin receptor subtype 3, member of the class A family of seven-transmembrane G ...
58-349 7.83e-05

bombesin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors; BRS-3 is classified as an orphan receptor and belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and gastrin-releasing peptide receptor (GRPR). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple primarily to the G proteins of G(q/11) family. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. BRS-3 is suggested to play a role in sperm cell division and maturation.


Pssm-ID: 320251 [Multi-domain]  Cd Length: 294  Bit Score: 43.76  E-value: 7.83e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  58 NLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSgRRWQLGRRLCQLWIACDVLCCTASIWNVTAIAL 137
Cdd:cd15123  18 NAILIKVFFKIKSMQTVPNIFITSLAFGDLLLLLTCVPVDATRYIA-DTWLFGRIGCKLLSFIQLTSVGVSVFTLTVLSA 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 138 DRYWSITRHLEYTLRTRKRVSNVMILLTWALSTVISLAPLLFGWGETYSEPSEECQVSREPSYTVFSTV----------G 207
Cdd:cd15123  97 DRYRAIVKPLELQTSDAVLKTCCKAGCVWIVSMLFAIPEAVFSDLYSFRDPEKNTTFEACAPYPVSEKIlqeihsllcfL 176
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 208 AFYL-PLCVVLFVYWKIYRAAkfrmgsrktnsvspvpeaveVKNATQHPqmvfTVRHATVTFQTEgdtwreqKEQRAALM 286
Cdd:cd15123 177 VFYIiPLSIISVYYFLIARTL--------------------YKSTFNMP----AEEHSHARKQIE-------SRKRVAKT 225
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 84370345 287 VGILIGVFVLCWFP---FFVTELISPLCSWDVPAIWKSIFLW---LGYSNSFFNPLIYTAFNRSYSSAF 349
Cdd:cd15123 226 VLVLVALFAFCWLPnhiLYLYRSFTYHTSVDSSAFHLIATIFsrvLAFSNSCVNPFALYWLSKSFRQHF 294
7tmA_GPR185-like cd15960
G protein-coupled receptor 185 and similar proteins, member of the class A family of ...
58-338 7.92e-05

G protein-coupled receptor 185 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR185, also called GPRx, is a member of the constitutively active GPR3/6/12 subfamily of G protein-coupled receptors. It plays a role in the maintenance of meiotic arrest in Xenopus laevis oocytes through G(s) protein, which leads to increased cAMP levels. In Xenopus laevis, GPR185 is primarily expressed in brain, ovary, and testis; however, its ortholog has not been identified in other vertebrate genomes. GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest.


Pssm-ID: 320626 [Multi-domain]  Cd Length: 268  Bit Score: 43.73  E-value: 7.92e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  58 NLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVhelsgrRWQLGRRLCQLWIACDVLCC-TASIWNVTAIA 136
Cdd:cd15960  18 NAIVIAILFYTPSLRAPMFILIGSLALADLLAGLGLIANFVA------IYVMNSEAVTLCSAGLLLAAfSASVCSLLAIT 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 137 LDRYWSITRHLEYTLRTRKRVSNVMILLTWALSTVISLAPLLfGWGETYSEPSeeCQVSREPSYTVFSTVGAFYLPL-CV 215
Cdd:cd15960  92 VDRYLSLYNALTYHTERTLTFTYGLLALLWLTCIGIGLLPAM-GWNCLRAPAS--CSVLRPVTKNNAAVLAVSFLLLfAL 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 216 VLFVYWKIYRAAkFRmgsrktnsvspvpeavevknatqHPQMVFTVRHATVTFQTEGDTwreqkeqRAALMVGILIGVFV 295
Cdd:cd15960 169 MMQLYLQICRIA-FR-----------------------HAQQIAVQHQFVNFCLASSTR-------KGVSTLSLILATFA 217
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 84370345 296 LCWFPFFVTELISplcSWDVPAIWKSIFLWLGYSNSFFNPLIY 338
Cdd:cd15960 218 FCWVPFAVYSMVA---DSSYPMIYTYYLVLPAACNSVINPIIY 257
7tmA_Glyco_hormone_R cd15136
glycoprotein hormone receptors, member of the class A family of seven-transmembrane G ...
49-345 8.61e-05

glycoprotein hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors (GPHRs) are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG) and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. GPHRs couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein.


Pssm-ID: 320264 [Multi-domain]  Cd Length: 275  Bit Score: 43.74  E-value: 8.61e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  49 FLAAATFTWNLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELS-------GRRWQLGRrLCQLWIACD 121
Cdd:cd15136   9 FVFLLALVGNIIVLLVLLTSRTKLTVPRFLMCNLAFADFCMGIYLGLLAIVDAKTlgeyynyAIDWQTGA-GCKTAGFLA 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 122 VLCCTASIWNVTAIALDRYWSITRHLEYTLRTRKRVSNVMILLTWALSTVISLAPlLFGWgETYSEPS----EECQVSRE 197
Cdd:cd15136  88 VFSSELSVFTLTVITLERWYAITHAMHLNKRLSLRQAAIIMLGGWIFALIMALLP-LVGV-SSYSKTSiclpFETETPVS 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 198 PSYTVFS---TVGAFylplCVVLFVYWKIYraakfrmgsrktnsvspvpeavevknatqhpqmvFTVRHAtvtfqteGDT 274
Cdd:cd15136 166 KAYVIFLllfNGLAF----LIICGCYIKIY----------------------------------LSVRGS-------GRA 200
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 84370345 275 WREqKEQRAALMVGILIGVFVLCWFP--FFVtelISPLCSWDVPAIWKS-IFLWLGYS-NSFFNPLIYTAFNRSY 345
Cdd:cd15136 201 ANS-NDTRIAKRMALLVFTDFLCWAPiaFFG---LTAAFGLPLISVSNAkILLVFFYPlNSCANPFLYAIFTKQF 271
7tmA_Anaphylatoxin_R-like cd14974
anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class ...
81-338 1.13e-04

anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes anaphylatoxin receptors, formyl peptide receptors (FPR), prostaglandin D2 receptor 2, GPR1, and related chemokine receptors. The anaphylatoxin receptors are a group of G-protein coupled receptors that bind anaphylatoxins. The members of this group include C3a and C5a receptors. The formyl peptide receptors (FPRs) are chemoattractant GPCRs that involved in mediating immune responses to infection. They are expressed mainly on polymorphonuclear and mononuclear phagocytes and bind N-formyl-methionyl peptides (FMLP), which are derived from the mitochondrial proteins of ruptured host cells or invading pathogens. Chemokine receptor-like 1 (also known as chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. Prostaglandin D2 receptor, also known as CRTH2, is a chemoattractant G-protein coupled receptor expressed on T helper type 2 cells that binds prostaglandin D2 (PGD2). PGD2 functions as a mast cell-derived mediator to trigger asthmatic responses and also causes vasodilation. PGD2 exerts its inflammatory effects by binding to two G-protein coupled receptors, the D-type prostanoid receptor (DP) and PD2R2 (CRTH2). PD2R2 couples to the G protein G(i/o) type which leads to a reduction in intracellular cAMP levels and an increase in intracellular calcium. GPR1 is an orphan receptor that can be activated by the leukocyte chemoattractant chemerin, thereby suggesting that some of the anti-inflammatory actions of chemerin may be mediated through GPR1.


Pssm-ID: 320105 [Multi-domain]  Cd Length: 274  Bit Score: 43.44  E-value: 1.13e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  81 SMAISDVLvAVLVMPLSLVHELSGRRWQLGRRLCQLWIACDVLCCTASIWNVTAIALDRYWSITR------HleytlRTR 154
Cdd:cd14974  40 NLALADFL-FCLFLPFLIVYIAMGHHWPFGSVLCKLNSFVISLNMFASVFLLTAISLDRCLLVLHpvwaqnH-----RTV 113
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 155 KRVSnVMILLTWALSTVISLAPLLF------GWGETYSEPSEECQ---VSREPSYTVFSTVGAFYLPLCVVLFVY----W 221
Cdd:cd14974 114 RLAS-VVCVGIWILALVLSVPYFVFrdtvthHNGRSCNLTCVEDYdlrRSRHKALTVIRFLCGFLLPLLIIAICYsviaV 192
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 222 KIYRaaKFRMGSRKTNSVspvpeavevknatqhpqmvftvrhatvtfqtegdtwreqkeqraalmVGILIGVFVLCWFPF 301
Cdd:cd14974 193 KLRR--KRLAKSSKPLRV-----------------------------------------------LLAVVVAFFLCWLPY 223
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 84370345 302 FVTELISPLCSWDVPAIWK-SIFL--WLGYSNSFFNPLIY 338
Cdd:cd14974 224 HVFALLELVAAAGLPEVVLlGLPLatGLAYFNSCLNPILY 263
7tmA_GPR31 cd15199
G protein-coupled receptor 31, member of the class A family of seven-transmembrane G ...
45-345 1.38e-04

G protein-coupled receptor 31, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR31, also known as 12-(S)-HETE receptor, is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid. Phylogenetic analysis showed that GPR31 and oxoeicosanoid receptor 1 (OXER1, GPR170) are the most closely related receptors to the hydroxycarboxylic acid receptor family (HCARs). GPR31, like OXER1, activates the ERK1/2 (MAPK3/MAPK1) pathway of intracellular signaling, but unlike the OXER1, does not cause increase in the cytosolic calcium level. GPR31 is also shown to activate NFkB. 12-(S)-HETE is a 12-lipoxygenase metabolite of arachidonic acid produced by mammalian platelets and tumor cells. It promotes tumor cells adhesion to endothelial cells and sub-endothelial matrix, which is a critical step for metastasis.


Pssm-ID: 320327 [Multi-domain]  Cd Length: 278  Bit Score: 43.24  E-value: 1.38e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  45 TLLGFLAAATFTWNLLVLAT-ILKVRTFHrvPHNL-VASMAISDVLVAVlVMPLSLVHELSGRRWQLGRRLCQLWIACDV 122
Cdd:cd15199   5 SLLILEFGLGLPGNAIALWTfIFRLKVWK--PYAVyLLNLVLADVLLLI-CLPFKAYFYLNGNRWSLGGGTCKALLFMLS 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 123 LCCTASIWNVTAIALDRYWSITRHLEYTLRTRKRVSNVMILLTWALSTVISLAPLLFGWGETYSE-----PSEECQVSRE 197
Cdd:cd15199  82 LSRGVSIAFLTAVALDRYFRVVHPRGKKNSLSLQAAPYISFLVWLLLVGLTIPTLLASQPKNFTEcnsfsPKDDEDFSDT 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 198 PSYTVFSTvgAFYLPLCVVLFVYWKIYRAAKfrmgsRKTNSVSPVPeavevknatqhpqmvftvrhatvtfqtegdtwre 277
Cdd:cd15199 162 WQEAVFFL--QFLLPFGLIVFCTVRIIRRLK-----KRLRDVGKQP---------------------------------- 200
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 84370345 278 qKEQRAALMVGILIGVFVLCWFPFFVTEL------ISPLCSWDVPAIWKS-IFLWLGYSNSFFNPLIY----TAFNRSY 345
Cdd:cd15199 201 -KLQRAMALVTSVVVVFGFCFLPCFLARVlmlifqNKESCNALNIAVHTYdVTMCLTYLNSVLDPIVYcfssPTFRSSY 278
7tmA_AT2R cd15191
type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G ...
43-338 1.80e-04

type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2R, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Moreover, AT1R promotes cell proliferation, whereas AT2R inhibits proliferation and stimulates cell differentiation. The AT2R is highly expressed during fetal development, however it is scarcely present in adult tissues and is induced in pathological conditions. Generally, the AT1R mediates many actions of Ang II, while the AT2R is involved in the regulation of blood pressure and renal function.


Pssm-ID: 341341 [Multi-domain]  Cd Length: 285  Bit Score: 42.82  E-value: 1.80e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  43 VLTLLGFLAaatftwNLLVLATILKVRTFHRVPHNLVASMAISDvLVAVLVMPLSLVHELSGRRWQLGRRLCQLWIACDV 122
Cdd:cd15191   9 IIFILGFLG------NSLVVCVFCHQSGPKTVASIYIFNLAVAD-LLFLATLPLWATYYSYGYNWLFGSVMCKICGSLLT 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 123 LCCTASIWNVTAIALDRYWSITRHLEyTLRTRKRVSNVMILLTWALSTVISLAPLLFGWGETYSEPS-EECQVSREPSYT 201
Cdd:cd15191  82 LNLFASIFFITCMSVDRYLAVVYPLR-SQRRRSWQARLVCLLVWVLACLSSLPTFYFRDTYYIEELGvNACIMAFPNEKY 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 202 VFSTVG--------AFYLPLCVVLFVYWKIYraakfrmgsrktnsvspvpeavevknatqhpqmvftvRHATvtfQTEGD 273
Cdd:cd15191 161 AQWSAGlalmkntlGFLIPLIVIATCYFGIG-------------------------------------RHLL---KTKGF 200
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 84370345 274 TWREQKEQRAALMVGILIGVFVLCWFPFFVTELISPLCS-------WDVPAIWK--SIFLWLGYSNSFFNPLIY 338
Cdd:cd15191 201 GKNKQRRDKVLKMVAAVVLAFLICWFPFHVLTFLDALARmgvinncWVITVIDKalPFAICLGFSNSCINPFLY 274
7tmA_S1PR2_Edg5 cd15347
sphingosine-1-phosphate receptor subtype 2 (S1PR2 or S1P2), also called endothelial ...
58-339 1.83e-04

sphingosine-1-phosphate receptor subtype 2 (S1PR2 or S1P2), also called endothelial differentiation gene 5 (Edg5), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320469 [Multi-domain]  Cd Length: 266  Bit Score: 42.49  E-value: 1.83e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  58 NLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLvheLSGRRwQLGRRLCQLWI--ACDVLCCTASIWNVTAI 135
Cdd:cd15347  18 NLLVLIAVARNKKFHSAMFFFIGNLAFSDLLAGVAFIANIL---LSGSV-TFRLTPVQWFIreGTAFITLSASVFSLLAI 93
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 136 ALDRYWSITRHLEYTLRTRKRVSnVMILLTWALSTVISLAPLLfGWGETYSEPSEECQVSREPSYTVFSTVGAFYLPLCV 215
Cdd:cd15347  94 AIERHVAITKVKLYGSDKNCRMV-LLIGACWVISIVLGGLPIL-GWNCIGNLEDCSTVLPLYSKHYILFVVTIFSIILLS 171
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 216 VLFVYWKIYRAAKfrmgsrktnsvspvpeavevknaTQHPQMVFTVRHATVTfqtegdtwreqkeqraalMVGILIGVFV 295
Cdd:cd15347 172 IVILYVRIYCIVR-----------------------SSHAEMAAPQTLALLK------------------TVTIVLGVFI 210
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 84370345 296 LCWFPFFVTELISPLCSW-DVPAIWKS-IFLWLGYSNSFFNPLIYT 339
Cdd:cd15347 211 VCWLPAFIILLLDTSCKVkSCPILYKAdYFFSVATLNSALNPVIYT 256
7tmA_CCK-AR cd15978
cholecystokinin receptor type A, member of the class A family of seven-transmembrane G ...
38-349 2.00e-04

cholecystokinin receptor type A, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320644 [Multi-domain]  Cd Length: 278  Bit Score: 42.55  E-value: 2.00e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  38 AFRVLVLTLLGFLaaaTFTWNLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSgRRWQLGRRLCQLW 117
Cdd:cd15978   1 TVRILLYSLIFLL---SVLGNSLIIAVLIRNKRMRTVTNIFLLSLAVSDLMLCLFCMPFTLIPNLL-KDFIFGSAVCKTA 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 118 IACDVLCCTASIWNVTAIALDRYWSITRHLEYTLRTRKRVSNVMILLTWALS-TVISLAPL---LFGWGETYSEPSEECQ 193
Cdd:cd15978  77 TYFMGISVSVSTFNLVAISLERYSAICKPLKSRVWQTKSHALKVIAATWCLSfTIMLPYPIysnLVPFTRINNSTGNMCR 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 194 V-----SREPSYTVFSTVGAFYLPLCVVLFVY----WKIYRAAKFRMGsrktnsvspvpeavevknatqhpqmvftvrha 264
Cdd:cd15978 157 LlwpndVTQQSWYIFLLLILFLIPGIVMMTAYglisLELYRGIKFLMA-------------------------------- 204
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 265 tvtfqtegdtwreqkEQRAALMVGILIGVFVLCWFPFFVTELISPLCSWDVPAIWK----SIFLWLGYSNSFFNPLIYTA 340
Cdd:cd15978 205 ---------------KKRVIRMLIVIVILFFLCWTPIFSANAWRAFDTRSADRLLSgapiSFIHLLSYTSACVNPIIYCF 269

                ....*....
gi 84370345 341 FNRSYSSAF 349
Cdd:cd15978 270 MNKRFRMGF 278
7tmA_S1PR4_Edg6 cd15349
sphingosine-1-phosphate receptor subtype 4 (S1PR4 or S1P4), also called endothelial ...
58-339 2.01e-04

sphingosine-1-phosphate receptor subtype 4 (S1PR4 or S1P4), also called endothelial differentiation gene 6 (Edg6), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320471 [Multi-domain]  Cd Length: 271  Bit Score: 42.46  E-value: 2.01e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  58 NLLVLATILKVRTFHRVPHNLVASMAISDVLVAV-----LVMPLSLVHELSGRRWQLGRRLcqLWIAcdvlcCTASIWNV 132
Cdd:cd15349  18 NLLVLLAILRRVRLRRWVYICLANIALSDLLTGTsylvnICLSGERTFRLTPALWFLREGL--LFTA-----LAASTFSL 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 133 TAIALDRYWSITRHLEYTLRTRKRVSNVMILLTWALSTVISLAPLLfGWgetysepseECQVSREPSYTVFSTVGAFYLP 212
Cdd:cd15349  91 LVTAVERYATMVRPVAENTATKTYRVYGMIVLCWILAFLIGFLPLL-GW---------NCLCDFRSCSSLLPLYSKSYIL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 213 LCVVLF---------VYWKIYraakfrmgsrktnsvspvpeavevknatqhpqmvftvRHATVTFQTEGDTWREQKEQRA 283
Cdd:cd15349 161 FCLVIFfiilltiigLYFAIY-------------------------------------CLVRASGQRVISARSRRRSLRL 203
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 84370345 284 ALMVGILIGVFVLCWFPFFVTELISPLCSwdvPAIWKSIF-----LWLGYSNSFFNPLIYT 339
Cdd:cd15349 204 LKTVLMILGAFMVCWGPLFILLLVDFFCS---SRSCKPLFgmewvLALAVLNSAINPLIYS 261
7tmA_GPR176 cd15006
orphan G protein-coupled receptor 176, member of the rhodopsin-like class A GPCR family; ...
58-344 2.58e-04

orphan G protein-coupled receptor 176, member of the rhodopsin-like class A GPCR family; GPR176 is a putative G protein-coupled receptor that belongs to the class A GPCR superfamily; no endogenous ligand for GPR176 has yet been identified. The class A rhodopsin-like GPCRs represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320135 [Multi-domain]  Cd Length: 289  Bit Score: 42.17  E-value: 2.58e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  58 NLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSgrrwqlgrRLCQLWIACDVLC----------CTA 127
Cdd:cd15006  17 NFMVLWSTCRTSVFKSVTNRFIKNLACSGICASLVCVPFDIVLSAS--------PHCCWWIYTLLFCkvikflhkvfCSV 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 128 SIWNVTAIALDRYWSITRHLEYTLRTRKrvSNVMILLTWALSTVISlAPLLFGWGETYSEPSEECQVSREPS-----YTV 202
Cdd:cd15006  89 TVLSFAAIALDRYYSVLYPLERKISDAK--SRDLVIYIWAHAVVAS-VPVFAVTNVTDIYAMSTCTESWGYSlghlvYVI 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 203 FSTVGAFYLPLCVVLFVYWKIYRAakfrmgsrktnsVSPVPEAVEVKNATQHPQMVFTVRHATvtfqtegdtwreQKEQR 282
Cdd:cd15006 166 IYNITTVILPVAVVFLFMILIRRA------------LSASQKKKVIIAALRTPQNTISIPYVS------------QREAE 221
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 84370345 283 AALMVGILIGVFVLCWFPfFVTELI--SPLCSWDVPAIWKSIFLWLGYSNSFFNPLIYTAFNRS 344
Cdd:cd15006 222 LHAMLLSMVLVFILCSVP-YATLVIyrTILNISDISVFLLLTAIWLPKVSLLANPLLFLTVNKS 284
7tmA_NTSR2 cd15356
neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G ...
43-185 2.75e-04

neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320478 [Multi-domain]  Cd Length: 285  Bit Score: 42.16  E-value: 2.75e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  43 VLTLLGFLAAATftwNLLVLATILKVRTFH----RVPHNLVaSMAISDVLVAVLVMPLSLVHELSGRR-WQLGRRLCQLW 117
Cdd:cd15356   6 VYALIWALGAAG---NALTIHLVLKKRSLRglqgTVHYHLV-SLALSDLLILLISVPIELYNFVWFHYpWVFGDLVCRGY 81
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 84370345 118 IACDVLCCTASIWNVTAIALDRYWSITRHLEYTLRTRKRVSNVMILLTWALSTVISLaPLLFGWGETY 185
Cdd:cd15356  82 YFVRDICSYATVLNIASLSAERYLAICQPLRAKRLLSKRRTKWLLALIWASSLGFAL-PMAFIMGQKY 148
7tmA_P2Y1 cd15377
P2Y purinoceptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
35-242 4.80e-04

P2Y purinoceptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y1 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. This family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 341350 [Multi-domain]  Cd Length: 289  Bit Score: 41.43  E-value: 4.80e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  35 FLSAFRVLVLtLLGFLAAATFTWNLLvlatilkvrtFHRVPHNLVA----SMAISDVLVaVLVMPLSLVHELSGRRWQLG 110
Cdd:cd15377   2 YLPAVYILVF-ITGFLGNSVAIWMFV----------FHMKPWSGISvymfNLALADFLY-VLTLPALIFYYFNKTDWIFG 69
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 111 RRLCQLWIACDVLCCTASIWNVTAIALDRYWSITRHLEYTLRTRKRVSNVMILLTWALsTVISLAPLLFGWGETYSEPS- 189
Cdd:cd15377  70 DAMCKLQRFIFHVNLYGSILFLTCISVHRYTGVVHPLKSLGRLKKKNAICISVLVWLI-VVVAISPILFYSGTGVRKNKt 148
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 190 ----EECQVSREPSYTVFS---TVGAFYLPLCVVLFVYWKIYRAAKFRMGSRKTNSVSPV 242
Cdd:cd15377 149 itcyDTTSDEYLRSYFIYSmctTVAMFCVPFILILGCYGLIVRALIYKDMKYTEENNAPL 208
7tmA_C5aR cd15114
complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of ...
72-343 5.61e-04

complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The anaphylatoxin receptors are a group of G-protein coupled receptors which bind anaphylatoxins; members of this group include C3a receptors and C5a receptors. Anaphylatoxins are also known as complement peptides (C3a, C4a and C5a) that are produced from the activation of the complement system cascade. These complement anaphylatoxins can trigger degranulation of endothelial cells, mast cells, or phagocytes, which induce a local inflammatory response and stimulate smooth muscle cell contraction, histamine release, and increased vascular permeability. They are potent mediators involved in chemotaxis, inflammation, and generation of cytotoxic oxygen-derived free radicals. In humans, a single receptor for C3a (C3AR1) and two receptors for C5a (C5AR1 and C5AR2, also known as C5L2 or GPR77) have been identified, but there is no known receptor for C4a.


Pssm-ID: 320242 [Multi-domain]  Cd Length: 274  Bit Score: 41.24  E-value: 5.61e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  72 HRVPHNLVASMAISDVLvAVLVMPLSLVHELSGRRWQLGRRLCQLWIACDVLCCTASIWNVTAIALDRYWSITRHLEYTL 151
Cdd:cd15114  31 RSVNAVWFLNLAVADLL-CCLSLPILAVPIAQDGHWPFGAAACKLLPSLILLNMYASVLLLTAISADRCLLVLRPVWCQN 109
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 152 RTRKRVSNVMILLTWALSTVISLAPLLF-GWGETYSEPSEECQV------SREPSYTVFSTVGAFYLPLCVVLFVYWKIY 224
Cdd:cd15114 110 HRRARLAWIACGAAWLLALLLTVPSFIYrRIHQEHFPEKTVCVVdyggstGVEWAVAIIRFLLGFLGPLVVIASCHGVLL 189
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 225 RAAKFRMGSRKTNsvspvpeavevknatqhpqmvftvrhatvtfqtegdTWReqkeqraaLMVGILIGvFVLCWFPFFVT 304
Cdd:cd15114 190 VRTWSRRRQKSRR------------------------------------TLK--------VVTAVVVG-FFLCWTPYHVV 224
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 84370345 305 ELI----SPLCSWDVPAI-WKSIFLWLGYSNSFFNPLIYTAFNR 343
Cdd:cd15114 225 GLIiaasAPNSRLLANALkADPLTVSLAYINSCLNPIIYVVAGR 268
7tmA_Glycoprotein_LRR_R-like cd14980
glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, ...
49-180 5.84e-04

glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the glycoprotein hormone receptors (GPHRs), vertebrate receptors containing 17 leucine-rich repeats (LGR4-6), and the relaxin family peptide receptors (also known as LGR7 and LGR8). They are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone receptor family contains receptors for the pituitary hormones, thyrotropin (thyroid-stimulating hormone receptor), follitropin (follicle-stimulating hormone receptor), and lutropin (luteinizing hormone receptor). Glycoprotein hormone receptors couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein. Two orphan GPCRs, LGR7 and LGR8, have been recently identified as receptors for the relaxin peptide hormones.


Pssm-ID: 320111 [Multi-domain]  Cd Length: 286  Bit Score: 41.07  E-value: 5.84e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  49 FLAAATFTWNLLVLATIL-KVRTFHRVPHNLVASMAISDVLVAVLVMPLSLV----HELSGRR---WQLGRrLCQLwiAC 120
Cdd:cd14980   9 IIGILALIGNILVIIWHIsSKKKKKKVPKLLIINLAIADFLMGIYLLIIAIAdqyyRGRYAQYseeWLRSP-PCLL--AC 85
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 84370345 121 dVLCCTASIWNV---TAIALDRYWSITRHLEYTLRTRKRVSNVMILLtWALSTVISLAPLLFG 180
Cdd:cd14980  86 -FLVSLSSLMSVlmmLLITLDRYICIVYPFSNKRLSYKSAKIILILG-WLFSIIFAAIPILYS 146
7tmA_P2Y1-like cd15168
P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of ...
82-338 6.40e-04

P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14). This cluster only includes P2Y1-like receptors as well as other closely related orphan receptors, such as GPR91 (a succinate receptor) and GPR80/GPR99 (an alpha-ketoglutarate receptor).


Pssm-ID: 341329 [Multi-domain]  Cd Length: 284  Bit Score: 41.15  E-value: 6.40e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  82 MAISDVLVAvLVMPLSLVHELSGRRWQLGRRLCQL---WIACDVLCctaSIWNVTAIALDRYWSITRHLEYTLRTRKRVS 158
Cdd:cd15168  42 LAVSDLLYL-LSLPFLIYYYANGDHWIFGDFMCKLvrfLFYFNLYG---SILFLTCISVHRYLGICHPLRSLGKLKKRHA 117
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 159 NVMILLTWALSTViSLAPLLFGWGETYSEPSEECQVSREP-------SYTVFSTVGAFYLPLCVVLFVYWKIYRAAKFRM 231
Cdd:cd15168 118 VAISVAVWILVLL-QLLPILFFATTGRKNNRTTCYDTTSPeelndyvIYSMVLTGLGFLLPLLIILACYGLIVRALIRKL 196
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 232 GSrktnsvspvpeavevkNATQHPQmvftvrhatvtfqtegdtwreqkeQRAALMVGILIGVFVLCWFPFFVTELI---- 307
Cdd:cd15168 197 GE----------------GVTSALR------------------------RKSIRLVIIVLALFAVCFLPFHVTRTInlaa 236
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 84370345 308 ------SPLCSWDVPAIWKSIFLWLGYSNSFFNPLIY 338
Cdd:cd15168 237 rllsgtASCATLNGIYVAYKVTRPLASLNSCLNPLLY 273
7tmA_OR13-like cd15232
olfactory receptor family 13 and related proteins, member of the class A family of ...
41-174 6.69e-04

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13A1 and 13G1) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320360 [Multi-domain]  Cd Length: 270  Bit Score: 40.70  E-value: 6.69e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  41 VLVLTLLGFLAAATFTWNLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSGRR-------------- 106
Cdd:cd15232   1 VLLFWLFLFLYAAALTGNSLIILAISTSPKLHTPMYFFLVNLSLVDIICTSTVVPKLLQNLLTERKtisfggcmaqlyff 80
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 84370345 107 -WQLGRRLCQLwiacdvlcctasiwnvTAIALDRYWSITRHLEYTLRTRKRVSNVMILLTWALSTVISL 174
Cdd:cd15232  81 tWSLGSELLLL----------------TAMAYDRYVAICHPLHYSTIMRKEVCVGLATGVWAIGMLNSA 133
7tmA_MWS_opsin cd15080
medium wave-sensitive opsins, member of the class A family of seven-transmembrane G ...
128-345 7.83e-04

medium wave-sensitive opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Medium Wave-Sensitive opsin, which mediates visual transduction in response to light at medium wavelengths (green). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 381742 [Multi-domain]  Cd Length: 280  Bit Score: 40.59  E-value: 7.83e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 128 SIWNVTAIALDRYWSITRHLEyTLRTRKRVSNVMILLTWALSTVISlAPLLFGWGETYSEPSE-ECQV---SREP----- 198
Cdd:cd15080  87 ALWSLVVLAIERYVVVCKPMS-NFRFGENHAIMGVAFTWVMALACA-APPLVGWSRYIPEGMQcSCGIdyyTLKPevnne 164
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 199 SYTVFSTVGAFYLPLCVVLFVYwkiyraakfrmgsrktnsvspvpeavevknatqhPQMVFTVRHATVTFQTEGDTWREQ 278
Cdd:cd15080 165 SFVIYMFVVHFTIPLIVIFFCY----------------------------------GRLVCTVKEAAAQQQESATTQKAE 210
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 84370345 279 KEqrAALMVGILIGVFVLCWFPF-FVTELISPLCSWDVPAIWKSIFLWLGYSNSFFNPLIYTAFNRSY 345
Cdd:cd15080 211 KE--VTRMVIIMVIAFLICWVPYaSVAFYIFTHQGSDFGPIFMTIPAFFAKSSAVYNPVIYILMNKQF 276
7tmA_FFAR cd14983
free fatty acid receptors, member of the class A family of seven-transmembrane G ...
58-338 8.21e-04

free fatty acid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the free fatty acid receptors (FFARs) which bind free fatty acids (FFAs). They belong to the class A G-protein coupled receptors and are composed of three members, each encoded by a separate gene (FFAR1, FFAR2, and FFAR3). These genes and a fourth pseudogene, GPR42, are localized together on chromosome 19. FFAR1 is a receptor for medium- and long-chain FFAs, whereas FFAR2 and FFAR3 are receptors for short chain FFAs (SCFAs), which have different ligand affinities. FFAR1 directly mediates FFA stimulation of glucose-stimulated insulin secretion and also indirectly increases insulin secretion by enhancing the release of incretin. FFAR2 activation by SCFA suppresses adipose insulin signaling, which leads to the inhibition of fat accumulation in adipose tissue. FAAR3 is expressed in intestinal L cells, which produces glucagon-like peptide 1 (GLP-1) and peptide YY (PYY), suggesting that this receptor may be involved in energy homeostasis. FFARs are considered important components of the body's nutrient sensing mechanism, and therefore, these receptors are potential therapeutic targets for the treatment of metabolic disorders, such as type 2 diabetes and obesity.


Pssm-ID: 320114 [Multi-domain]  Cd Length: 278  Bit Score: 40.49  E-value: 8.21e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  58 NLLVL-ATILKVRTFHRVPHNLVASMAISDvLVAVLVMPLSLVHELSGRrWQLGRRLCQLWIACDVLCCTASIWNVTAIA 136
Cdd:cd14983  18 NLLALyAFVNRARLRLTPNVIYMINLCLSD-LVFILSLPIKIVEALSSA-WTLPAVLCPLYNLAHFSTLYASTCFLTAIS 95
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 137 LDRYWSITRHLEYTLRTRKRVSNVMILLTWALS----TVISLAPLLFGWGET----------YSEPSEECQVSREPSYTV 202
Cdd:cd14983  96 AGRYLGVAFPIKYQLYKKPLYSCLVCVAIWALVifhvTLVFILETSGGTLDIntpvgnsstcYENFTPEQLALLAPVRLE 175
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 203 FSTVgAFYLPLCVVLFVYWKIYRA-AKFRMGsrktnsvspvpeavevknatqhpqmvftvrhatvtfqtegdtwrEQKEQ 281
Cdd:cd14983 176 LSLV-LFFLPLAITAFCYVRCIRIlVRSRLH--------------------------------------------ERRKR 210
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 84370345 282 RAALMVGILIGVFVLCWFPFFVTELISPLCSWDVPaiWKSIFLWLGYSNSFFNPLIY 338
Cdd:cd14983 211 RAVRVAVSTLLTFVVCFGPYNISHVVGFVRHESVW--WRKLALLTSTCNAFLDPLIF 265
7tmA_Relaxin_R cd15137
relaxin family peptide receptors, member of the class A family of seven-transmembrane G ...
50-178 8.23e-04

relaxin family peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes relaxin/insulin-like family peptide receptor 1 (RXFP1 or LGR7) and 2 (RXFP2 or LGR8), which contain a very large extracellular N-terminal domain with numerous leucine-rich repeats responsible for hormone recognition and binding. Relaxin is a member of the insulin superfamily that has diverse actions in both reproductive and non-reproductive tissues. The relaxin-like peptide family includes relaxin-1, relaxin-2, and the insulin-like (INSL) peptides such as INSL3, INSL4, INSL5 and INSL6. The relaxin family peptides share high structural but low sequence similarity, and exert their physiological functions by activating a group of four GPCRs, RXFP1-4. Relaxin and INSL3 are the endogenous ligands for RXFP1 and RXFP2, respectively. Upon receptor binding, relaxin activates a variety of signaling pathways to produce second messengers such as cAMP.


Pssm-ID: 320265 [Multi-domain]  Cd Length: 284  Bit Score: 40.65  E-value: 8.23e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  50 LAAATFTWNLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLV----------HELSGRR-WqlgrrLCQLWI 118
Cdd:cd15137  10 VGIIALLGNLFVLIWRLKYKEENKVHSFLIKNLAIADFLMGVYLLIIASVdlyyrgvyikHDEEWRSsW-----LCTFAG 84
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 119 ACDVLCCTASIWNVTAIALDRYWSITRHLEYTLRTRKRVSNVMILLtWALSTVISLAPLL 178
Cdd:cd15137  85 FLATLSSEVSVLILTLITLDRFICIVFPFSGRRLGLRRAIIVLACI-WLIGLLLAVLPLL 143
7tmA_ACKR4_CCR11 cd15176
atypical chemokine receptor 4, member of the class A family of seven-transmembrane G ...
82-255 1.08e-03

atypical chemokine receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR4 was first reported to bind several CC chemokines including CCL19, CCL21, and CCL25 and was originally designated CCR11. AKCR4 is unable to couple to G-protein and, instead, it preferentially mediates beta-arrestin dependent processes, such as receptor internalization, after ligand binding. Thus, ACKR4 may act as a scavenger receptor to suppress the effects of proinflammatory chemokines. Unlike the classical chemokine receptors that contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320304 [Multi-domain]  Cd Length: 276  Bit Score: 40.11  E-value: 1.08e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  82 MAISDVLVaVLVMPLSLVHELSGrrWQLGRRLCQLWIACDVLCCTASIWNVTAIALDRYWSITRhleytLRTRKRVSN-- 159
Cdd:cd15176  42 LAVADLLL-LFTLPFWAADAVNG--WVLGTAMCKITSALYTMNFSCGMQFLACISVDRYVAITK-----ATSRQFTGKhc 113
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 160 -VMILLTWALSTVISLAPLLFGWGETYSEPSeECQVSRePSYTVFST---------VGAFYLPLCVVLFVYWKIYRAAKF 229
Cdd:cd15176 114 wIVCLCVWLLAILLSIPDLVFSTVRENSDRY-RCLPVF-PPSLVTSAkatiqilevLLGFVLPFLVMVFCYSRVARALSR 191
                       170       180
                ....*....|....*....|....*.
gi 84370345 230 RMGSRKTNSVSPVPEAVEVKNATQHP 255
Cdd:cd15176 192 TPNVKKSRALKVLLAVVGVFIVTQLP 217
7tmA_NMBR cd15125
neuromedin B receptor, member of the class A family of seven-transmembrane G protein-coupled ...
58-300 1.15e-03

neuromedin B receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin B receptor (NMBR), also known as BB1, is a G-protein coupled receptor whose endogenous ligand is the neuropeptide neuromedin B. Neuromedin B is a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. NMBR is widely distributed in the CNS, with especially high levels in olfactory nucleus and thalamic regions. The receptor couples primarily to a pertussis-toxin-insensitive G protein of the Gq/11 family, which leads to the activation of phospholipase C. NMBR belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include gastrin-releasing peptide receptor (GRPR) and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin.


Pssm-ID: 320253 [Multi-domain]  Cd Length: 292  Bit Score: 40.32  E-value: 1.15e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  58 NLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSgRRWQLGRRLCQLWIACDVLCCTASIWNVTAIAL 137
Cdd:cd15125  18 NITLVKIFITNSAMRSVPNIFISSLAAGDLLLLVTCVPVDASRYFY-EEWMFGTVGCKLIPVIQLTSVGVSVFTLTALSA 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 138 DRYWSITRHLEYTLRTRKRVSNVMILLTWALSTVISLAPLLFGWGETYSEPSEECQVSREP----------SYTVFSTVG 207
Cdd:cd15125  97 DRYKAIVNPMDIQTSSAVLRTCLKAIAIWVVSVLLAVPEAVFSEVAHIMPDDNTTFTACIPypqtdemhpkIHSVLIFLV 176
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 208 AFYLPLCVVLFVYWKIYRAAkfrmgsrktnsvspvpeaveVKNATQHPQMVftvrhatvtfqTEGDTWREQKEQRAALMV 287
Cdd:cd15125 177 YFLIPLAIISIYYYHIAKTL--------------------IKSAHNIPGEY-----------SEHSKRQMETRKRLAKIV 225
                       250
                ....*....|...
gi 84370345 288 GILIGVFVLCWFP 300
Cdd:cd15125 226 LVFVGLFAFCWFP 238
7tmA_SWS2_opsin cd15077
short wave-sensitive 2 opsins, member of the class A family of seven-transmembrane G ...
49-347 1.42e-03

short wave-sensitive 2 opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Short Wave-Sensitive opsin 2 (SWS2), which mediates visual transduction in response to light at short wavelengths (violet to blue). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320205 [Multi-domain]  Cd Length: 280  Bit Score: 39.81  E-value: 1.42e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  49 FLAAATFTWNLLVLATILKVRTFHRVPHNLVASMAISDVLVaVLVMPLSLVHELSGRRWQLGRRLCQLWIACDVLCCTAS 128
Cdd:cd15077   9 FLVIAGFPINVLTIICTIKYKKLRSHLNYILVNLAVANLIV-VCFGSTTAFYSFSQMYFVLGPLACKIEGFTATLGGMVS 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 129 IWNVTAIALDRYWSITRHL-EYTLRTRKRVsnVMILLTWALSTVISLAPLlFGWGETYSEpseECQVSREP--------- 198
Cdd:cd15077  88 LWSLAVVAFERFLVICKPLgNFTFRGTHAI--IGCIATWVFGLAASLPPL-FGWSRYIPE---GLQCSCGPdwyttnnkw 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 199 ---SYTVFSTVGAFYLPLCVVLFVYwkiyraakfrmgsrktnsvspvpeavevknatqhPQMVFTVRhaTVTFQTEGDTW 275
Cdd:cd15077 162 nneSYVMFLFCFCFGVPLSIIVFSY----------------------------------GRLLLTLR--AVAKQQEQSAS 205
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 84370345 276 REQKEQRAALMVGILIGVFVLCWFPFFVTELisplcsWDVPAIWKSIFLWLGY-------SNSFFNPLIYTAFNRSYSS 347
Cdd:cd15077 206 TQKAEREVTKMVVVMVLGFLVCWLPYASFAL------WVVTNRGEPFDLRLASipsvfskASTVYNPVIYVFMNKQFRS 278
7tmA_RNL3R1 cd15926
relaxin 3 receptor 1 (RNL3R1), member of the class A family of seven-transmembrane G ...
58-179 1.71e-03

relaxin 3 receptor 1 (RNL3R1), member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled receptor RNL3R1 is also known as GPCR135, relaxin family peptide receptor 3 (RXFP3), and somatostatin- and angiotensin-like peptide receptor (SALPR). RNL3/relaxin-3, a member of the insulin superfamily, is an endogenous neuropeptide ligand for RNL3R1. RNL3R1 is predominantly expressed in brain regions and implicated in stress, anxiety, and feeding, and metabolism. RNL3R1 signals through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation, and also activates Erk1/2 signaling pathway.


Pssm-ID: 320592 [Multi-domain]  Cd Length: 288  Bit Score: 39.88  E-value: 1.71e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  58 NLLVLATILKVRTFHRVPHNL-VASMAISDvLVAVLVMPLSLVHELSGRRWQLGRRLCQLWIACDVLCCTASIWNVTAIA 136
Cdd:cd15926  18 NLLVLYLMKSKQGWKKSSINLfVTSLAVTD-FQFVLTLPFWAVENALDFTWLFGKAMCKIVSYVTAMNMYASVFFLTAMS 96
                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 84370345 137 LDRYWSITRHLEYTLRTRKRVSNVMILLTWALSTVISLAPLLF 179
Cdd:cd15926  97 VARYHSVASALKSKRRRGCCSAKWLCVLIWVLAILASLPNAIF 139
7tmA_FPR-like cd15117
N-formyl peptide receptors, member of the class A family of seven-transmembrane G ...
92-345 1.91e-03

N-formyl peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The formyl peptide receptors (FPRs) are chemoattractant GPCRs that involved in mediating immune responses to infection. They are expressed at elevated levels on polymorphonuclear and mononuclear phagocytes. FPRs bind N-formyl peptides, which are derived from the mitochondrial proteins of ruptured host cells or invading pathogens. Activation of FPRs by N-formyl peptides such as N-formyl-Met-Leu-Phe (FMLP) triggers a signaling cascade that stimulates neutrophil accumulation, phagocytosis and superoxide production. These responses are mediated through a pertussis toxin-sensitive G(i) protein that activates a PLC-IP3-calcium signaling pathway. While FPRs are involved in host defense responses to bacterial infection, they can also suppress the immune system under certain conditions. Yet, the physiological role of the FPR family is not fully understood.


Pssm-ID: 320245 [Multi-domain]  Cd Length: 288  Bit Score: 39.72  E-value: 1.91e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  92 LVMPLSLVHELSGRRWQLGRRLCQLWIACDVLCCTASIWNVTAIALDRYWSITRHLEYTLRTRKRVSNVMILLTWALSTV 171
Cdd:cd15117  50 LFLPFSVVYTALGFHWPFGWFLCKLYSTLVVFNLFASVFLLTLISLDRCVSVLWPVWARNHRTPARAALVAVGAWLLALA 129
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 172 ISLAPLLF-----------------GWGETYSEPSE--ECQVSREPSYTVFSTVGAFYLPLCVVLFVYWKIyrAAKFrmg 232
Cdd:cd15117 130 LSGPHLVFrdtrkengcthcylnfdPWNETAEDPVLwlETVVQRLSAQVITRFVLGFLVPLVIIGGCYGLI--AARL--- 204
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 233 srktnsvspvpeavevknatqhpqmvftvrhatvtfqtegdtWREQ--KEQRAALMVGILIGVFVLCWFPFFVTELISPL 310
Cdd:cd15117 205 ------------------------------------------WREGwvHSSRPFRVLTAVVAAFFLCWFPFHLVSLLELV 242
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 84370345 311 CSWDVPAIWKSIFLW-------LGYSNSFFNPLIYTAFNRSY 345
Cdd:cd15117 243 VILNQKEDLNPLLILllplsssLACVNSCLNPLLYVFVGRDF 284
7tmA_AT1R cd15192
type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G ...
58-179 2.26e-03

type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2R, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Moreover, AT1R promotes cell proliferation, whereas AT2R inhibits proliferation and stimulates cell differentiation. The AT2R is highly expressed during fetal development, however it is scarcely present in adult tissues and is induced in pathological conditions. Generally, the AT1R mediates many actions of Ang II, while the AT2R is involved in the regulation of blood pressure and renal function.


Pssm-ID: 320320 [Multi-domain]  Cd Length: 285  Bit Score: 39.34  E-value: 2.26e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  58 NLLVLATI---LKVRTfhrVPHNLVASMAISDvLVAVLVMPLSLVHELSGRRWQLGRRLCQLWIACDVLCCTASIWNVTA 134
Cdd:cd15192  18 NSLVVIVIycyMKLKT---VANIFLLNLALAD-LCFLITLPLWAAYTAMEYHWPFGNFLCKIASALVSFNLYASVFLLTC 93
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 84370345 135 IALDRYWSITRHLEYTLRTRKRVSNVMILLTWALSTVISLAPLLF 179
Cdd:cd15192  94 LSIDRYLAIVHPMKSRLRRTLVVARVTCIVIWLLAGVASLPAIIH 138
7tmA_PAR4 cd15372
protease-activated receptor 4, member of the class A family of seven-transmembrane G ...
78-226 2.26e-03

protease-activated receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320494 [Multi-domain]  Cd Length: 274  Bit Score: 39.35  E-value: 2.26e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  78 LVASMAISDVLVaVLVMPLSLVHELSGRRWQLGRRLCQLWIA-------CDVLCctasiwnVTAIALDRYWSITRHL-EY 149
Cdd:cd15372  37 FLINLAVADLLL-ILVLPFKISYHFLGNNWPFGEGLCRVVTAffygnmyCSVLL-------LMCISLDRYLAVVHPFfAR 108
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 150 TLRTRkRVSNVMILLTWALSTVISLAPLLFGWGETYSEPS---------EECQVSREPSYTVFSTVGAFYLPLCVVLFVY 220
Cdd:cd15372 109 TLRSR-RFALCMCTAIWLIAAALTLPLTLQRQSYPLERLNitlchdvlpLDEQDTYLFYYFACLAVLGFLLPLVVILFCY 187

                ....*.
gi 84370345 221 WKIYRA 226
Cdd:cd15372 188 GSVLHT 193
7tmA_NTSR cd15130
neurotensin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
41-183 2.39e-03

neurotensin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320258 [Multi-domain]  Cd Length: 281  Bit Score: 39.16  E-value: 2.39e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  41 VLVLTLLGFLAAATFTWNLLVLATILKVRTFHRVP---HNLVASMAISDVLVAVLVMPLSLVHELSGRR-WQLGRRLCQL 116
Cdd:cd15130   1 VLVTAIYLALFVVGTVGNSVTLFTLARKKSLQSLQstvRYHLGSLALSDLLILLLAMPVELYNFIWVHHpWAFGDAGCRG 80
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 84370345 117 WIACDVLCCTASIWNVTAIALDRYWSITRHLEY-TLRTRKRvSNVMILLTWALSTVISLaPLLFGWGE 183
Cdd:cd15130  81 YYFLRDACTYATALNVASLSVERYLAICHPFKAkTLMSRSR-TKKFISAIWLASALLAI-PMLFTMGL 146
7tmA_SWS1_opsin cd15076
short wave-sensitive 1 opsins, member of the class A family of seven-transmembrane G ...
47-345 2.47e-03

short wave-sensitive 1 opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Short Wave-Sensitive opsin 1 (SWS1), which mediates visual transduction in response to light at short wavelengths (ultraviolet to blue). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320204 [Multi-domain]  Cd Length: 280  Bit Score: 39.03  E-value: 2.47e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  47 LGFLAAATFTWNLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSGRrWQLGRRLCQLWIACDVLCCT 126
Cdd:cd15076   7 MGFVFIVGTPLNAIVLFVTIKYKKLRQPLNYILVNISLAGFIFCIFSVFPVFVASAQGY-FFFGRTVCALEAFVGSLAGL 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 127 ASIWNVTAIALDRYWSITRHLEyTLRTRKRVSNVMILLTWALSTVISLAPLlFGWGEtYSEPSEECQVS----------R 196
Cdd:cd15076  86 VTGWSLAFLAFERYIVICKPFG-NFRFGSKHALGAVVATWIIGIGVSLPPF-FGWSR-YIPEGLQCSCGpdwytvgtkyR 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 197 EPSYTVFSTVGAFYLPLCVVLFVYWKIYRAAKfrmgsrktnsvspvpeavevknatqhpqmvftvrhATVTFQTEGDTwR 276
Cdd:cd15076 163 SEYYTWFLFIFCFIVPLSIIIFSYSQLLGALR-----------------------------------AVAAQQQESAS-T 206
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 84370345 277 EQKEQRAALMVGILIGVFVLCWFPFFVTELIspLCSWDVPAI---WKSIFLWLGYSNSFFNPLIYTAFNRSY 345
Cdd:cd15076 207 QKAEREVSRMVVVMVGSFCLCYVPYAALAMY--MVNNRDHGLdlrLVTIPAFFSKSSCVYNPIIYCFMNKQF 276
7tmA_GPR35-like cd15164
G protein-coupled receptor 35 and similar proteins, member of the class A family of ...
128-307 2.99e-03

G protein-coupled receptor 35 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR35 shares closest homology with GPR55, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A number of studies have suggested that GPR35 may play important physiological roles in hypertension, atherosclerosis, nociception, asthma, glucose homeostasis and diabetes, and inflammatory bowel disease. GPR35 is thought to be responsible for brachydactyly mental retardation syndrome, which is associated with a deletion comprising chromosome 2q37 in human, and is also implicated as a potential oncogene in stomach cancer. Several endogenous ligands for GPR35 have been identified including kynurenic acid, 2-oleoyl lysophosphatidic acid, and zaprinast. GPR35 couples to G(13) and G(i/o) proteins.


Pssm-ID: 320292 [Multi-domain]  Cd Length: 272  Bit Score: 38.78  E-value: 2.99e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 128 SIWNVTAIALDRYWSITRHLE-YTLRTRKRVSNVMILLtWALstVISLAPLLFGWGEtysEPSEEC--QVSREPSY-TVF 203
Cdd:cd15164  84 SIYIITAIAVDRYIAIKYPLKaKSLRSPRKAALTCGLL-WVL--VIISVSLRLAWEE---QEENFCfgKTSTRPSKrTLI 157
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 204 STVGAFYLPLCVVLFVYWKIYRAAKFRMgsrKTNSvspvpeavevknatqhpqmvftvrhatvtfqtegdtwREQKE-QR 282
Cdd:cd15164 158 FSLLGFFIPLIILSFCSIQVIRSLKKKK---KTNP-------------------------------------HEEKLiQK 197
                       170       180
                ....*....|....*....|....*
gi 84370345 283 AALMVGILIGVFVLCWFPFFVTELI 307
Cdd:cd15164 198 AIYIVSANLIVFIVCFLPLHIGLLV 222
7tmA_PAR3 cd15371
protease-activated receptor 3, member of the class A family of seven-transmembrane G ...
42-226 3.22e-03

protease-activated receptor 3, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320493 [Multi-domain]  Cd Length: 274  Bit Score: 39.01  E-value: 3.22e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  42 LVLTLLGFLAAATFTWNLLVLATILKVRTFHrvphnlvASMAISDVLVAVLvMPLSLVHELSGRRWQLGRRLCQLWIACD 121
Cdd:cd15371   8 IIVVVLGVPSNAIILWMLFFRLRSVCTAIFY-------ANLAISDLLFCIT-LPFKIVYHLNGNNWVFGETMCRIITITF 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 122 VLCCTASIWNVTAIALDRYWSITRHLEYTLRTRKRVSNVMILLTWALSTVISLAplLFGWGETYS------------EPS 189
Cdd:cd15371  80 YGNMYCSILLLTCISINRYLAIVHPFIYRSLPKKTYAVLICALVWTIVFLYMLP--FFILKQTYYlkelnittchdvLPE 157
                       170       180       190
                ....*....|....*....|....*....|....*..
gi 84370345 190 EECQVSREPSYTVFSTVGAFYLPLCVVLFVYWKIYRA 226
Cdd:cd15371 158 CEQNSNFQFYYFISMAVFGFLIPLVITIFCYISIIRT 194
7tmA_BNGR-A34-like cd15000
putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of ...
58-349 4.05e-03

putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor BNGR-A34 found in silkworm and its closely related proteins from invertebrates. They are members of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320131 [Multi-domain]  Cd Length: 285  Bit Score: 38.56  E-value: 4.05e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  58 NLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSgRRWQLGRRLCQLWIACDVLCCTASIWNVTAIAL 137
Cdd:cd15000  17 NFVLLYILASNRSLRTPTNLLIGNMALADLLTLLVCPWMFLVHDFF-QNYVLGSVGCKLEGFLEGSLLLASVLALCAVSY 95
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 138 DRYWSITrhLEYTLRTRKRVSNVMILLTWALSTVISLaPLLF----------GWGETYSepSEECQVSrePSYTVFSTVG 207
Cdd:cd15000  96 DRLTAIV--LPSEARLTKRGAKIVIVITWIVGLLLAL-PLAIyrsyrerqwkNFLETYC--AENTQVL--PIYWHVIITV 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 208 AFYLPLCVVLFVY----WKIYRAAkfRMGSRKTNsvspvpeavevknatqhpqmvftvrHATVTFQtegdtwreqkeQRA 283
Cdd:cd15000 169 LVWLPLGIMLICYsaifWKLDKYE--RRVLRREH-------------------------PSVVRYK-----------KKA 210
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 84370345 284 ALMVGILIGVFVLCWFPF----------FVTELISPLCSWDVPAIWkSIFLWLGYSNSFFNPLIYTAFNRSYSSAF 349
Cdd:cd15000 211 AKTLFIVLITFVVCRIPFtalifyryklVPNDNTQNSVSGSFHILW-FASKYLMFLNAAVNPLIYGFTNENFRKAF 285
7tmA_CCR6 cd15172
CC chemokine receptor type 6, member of the class A family of seven-transmembrane G ...
41-270 4.80e-03

CC chemokine receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR6 is the only known receptor identified for the chemokine CCL20 (also known as macrophage inflammatory protein-3alpha, MIP-3alpha). CCR6 is expressed by all mature human B cells, effector memory T-cells, and dendritic cells found in the gut mucosal immune system. CCL20 contributes to recruitment of CCR6-expressing cells to Peyer's patches and isolated lymphoid follicles in the intestine, thereby promoting the assembly and maintenance of organized lymphoid structures. Also, CCL20 expression is highly inducible in response to inflammatory signals. Thus, CCL20 is involved in both inflammatory and homeostatic functions in the immune system. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341330 [Multi-domain]  Cd Length: 281  Bit Score: 38.20  E-value: 4.80e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  41 VLVLTLLGFLAAATFTWNLLVLATILKVRTFHRVPHNLVASMAISDVLVaVLVMPLSLVHELSgrRWQLGRRLCQLWIAC 120
Cdd:cd15172   1 VFVPVIYSLICVVGLIGNSLVVITYAFYKRTKSMTDVYLLNMAIADILF-VLTLPFWAVYEAH--QWIFGNFSCKLLRGI 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 121 DVLCCTASIWNVTAIALDRYWSI---TRHLEYTLRTRKRvSNVMILLTWALSTVISLAPLLFGwgETYSEPSEECQVSrE 197
Cdd:cd15172  78 YAINFYSGMLLLACISVDRYIAIvqaTKSFRLRSRTLAY-SKLICAAVWLLAILISLPTFIFS--EVYDFGLEEQYVC-E 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 198 PSYTVFSTVG-------------AFYLPLCVVLFVYWKIYRAAKFRMGSRKTNSVSPVPEAVEVKNATQHPQMVFTVRHA 264
Cdd:cd15172 154 PKYPKNSTAImwkllvlslqvslGFFIPLLVMIFCYSFIIKTLLQAQNSQRHKAVRVVVAVVLVFLVCQVPYNIVLLIEA 233

                ....*.
gi 84370345 265 TVTFQT 270
Cdd:cd15172 234 INLGEQ 239
7tmA_Gal2_Gal3_R cd15097
galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G ...
58-349 4.97e-03

galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320225 [Multi-domain]  Cd Length: 279  Bit Score: 38.27  E-value: 4.97e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  58 NLLVLATILKVRTFHRVPHNL-VASMAISDVLVAVLVMPL-SLVHELSGrrWQLGRRLCQLWIACDVLCCTASIWNVTAI 135
Cdd:cd15097  18 NSLVLAVLLRSGQSGHNTTNLfILNLSVADLCFILFCVPFqATIYSLEG--WVFGSFLCKAVHFFIYLTMYASSFTLAAV 95
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 136 ALDRYWSItrhlEYTLRTRK----RVSNVMILLTWALSTVISlAPLLFGWGETYSEPSEEC----QVSREPSYTVFSTVG 207
Cdd:cd15097  96 SVDRYLAI----RYPLRSRElrtpRNAVAAIALIWGLSLLFA-GPYLSYYDLIDYANSTVCmpgwEEARRKAMDTCTFAF 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 208 AFYLPLCVVLFVYwkiYRAAKFRMgsrktNSVSPVPEAVEVKNATQhpqmvftvrhatvtfqtegdtwreqkeqRAALMV 287
Cdd:cd15097 171 GYLIPVLVVSLSY---TRTIKYLW-----TAVDPLEAMSESKRAKR----------------------------KVTKMI 214
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 84370345 288 GILIGVFVLCWFPFFVteLIspLCSW--DVPAIWKSIFLWL-----GYSNSFFNPLIYTAFNRSYSSAF 349
Cdd:cd15097 215 IIVTALFCLCWLPHHV--VI--LCYLygDFPFNQATYAFRLlshcmAYANSCLNPIVYALVSKHFRKGF 279
7tmA_FSH-R cd15360
follicle-stimulating hormone receptor, member of the class A family of seven-transmembrane G ...
46-177 6.11e-03

follicle-stimulating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. FSH-R functions in gonad development and is found in the ovary, testis, and uterus. Defects in this receptor cause ovarian dysgenesis type 1, and also ovarian hyperstimulation syndrome. The FSH-R activation couples to the G(s)-protein and stimulates adenylate cyclase, thereby promoting cAMP production.


Pssm-ID: 320482  Cd Length: 275  Bit Score: 37.92  E-value: 6.11e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  46 LLGFLAAATFTWNLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSGRR-------WQLGRRlCQLWI 118
Cdd:cd15360   6 LIWFINILAITGNIVVLAILLTSQYKLTVPRFLMCNLAFADLCMGIYLLLIASVDIRTKSQyynyaidWQTGAG-CAAAG 84
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 84370345 119 ACDVLCCTASIWNVTAIALDRYWSITRHLEYTLRTRKRVSNVMILLTWALSTVISLAPL 177
Cdd:cd15360  85 FFTVFASELSVYTLTVITLERWHTITYAMQLDRKVRLRHAAVIMVGGWIFAFTVALLPI 143
7tmA_CysLTR cd15921
cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G ...
78-338 6.77e-03

cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320587 [Multi-domain]  Cd Length: 283  Bit Score: 37.87  E-value: 6.77e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  78 LVASMAISDVLVaVLVMPLSLVHELSGRRWQLGRRLCQLWIACDVLCCTASIWNVTAIALDRYWSITRHLEYTLRTRKRV 157
Cdd:cd15921  38 LMVNLAISDLLL-VCTLPLRLTYYVLNSHWPFGDIACRIILYVLYVNMYSSIYFLTALSVFRYLALVWPYLYLRVQTHSV 116
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 158 SNVMILLTWALsTVISLAPLLFGWGETYSEPSEEC------QVSREPSYTVFSTVGAFYLPLCVVLFVYWKIYRaakfrm 231
Cdd:cd15921 117 AGIICGLIWIL-MGLASSPLLFAKSKQHDEGSTRClelahdAVDKLLLINYVTLPVGFVVPFMTVIFCYIFIIK------ 189
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 232 gsrktnsVSPVPEAVEVKNATQHpqmvftvrhatvtfqtegdtwreqkeQRAALMVGILIGVFVLCWFPFFVTELISpLC 311
Cdd:cd15921 190 -------NLLKPSPALGRTRPSR--------------------------RKACALIIISLGIFLVCFLPYHIVRTIH-LI 235
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 84370345 312 SWDVP--------AIWKS--IFLWLGYSNSFFNPLIY 338
Cdd:cd15921 236 TERQIkescgyilRVRKAavITLCLAASNSCFDPLLY 272
7tmA_CX3CR1 cd15186
CX3C chemokine receptor 1, member of the class A family of seven-transmembrane G ...
35-225 7.66e-03

CX3C chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; CX3CR1 is an inflammatory receptor specific for CX3CL1 (also known as fractalkine in human), which is involved in the adhesion and migration of leukocytes. The CX3C chemokine subfamily is only represented by CX3CL1, which exists in both soluble and membrane-anchored forms. Membrane-anchored form promotes strong adhesion of receptor-bearing leukocytes to CX3CL1-expressing endothelial cells. On the other hand, soluble CX3CL1, which is released by the proteolytic cleavage of membrane-anchored CX3CL1, is a potent chemoattractant for CX3CR1-expressing T cells and monocytes. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling.


Pssm-ID: 320314 [Multi-domain]  Cd Length: 273  Bit Score: 37.51  E-value: 7.66e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  35 FLSAFRVLVLTLlgflaaaTFTWNLLVLATILKVRTFHRVPHNLVASMAISDVLVaVLVMPLSLVHELSGrrWQLGRRLC 114
Cdd:cd15186   2 FLSIFYSLVFAF-------GLVGNLLVVLALTNSGKSKSITDIYLLNLALSDLLF-VATLPFWTHYLINE--WGLHNAMC 71
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345 115 QLWIACDVLCCTASIWNVTAIALDRYWSITRhLEYTLRTRKRVSNVMILL-TWALSTVISLAPLLFGW---GETYSEPSE 190
Cdd:cd15186  72 KLTTAFFFIGFFGGIFFITVISIDRYLAIVL-AANSMNNRTVQHGVTISLgVWAAAILVAVPQFMFTKmkeNECLGDYPE 150
                       170       180       190
                ....*....|....*....|....*....|....*
gi 84370345 191 ECQVSREPSYTVFSTVGAFYLPLCVVLFVYWKIYR 225
Cdd:cd15186 151 VLQEIWPVLRNVELNFLGFLLPLLIMSYCYFRIIQ 185
7tmA_ET-BR cd15976
endothelin B receptor, member of the class A family of seven-transmembrane G protein-coupled ...
58-174 9.62e-03

endothelin B receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320642 [Multi-domain]  Cd Length: 296  Bit Score: 37.53  E-value: 9.62e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370345  58 NLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSlVHELSGRRWQLGRRLCQLWIACDVLCCTASIWNVTAIAL 137
Cdd:cd15976  18 NSTLLRIIYKNKCMRNGPNILIASLALGDLLHIIIDIPIN-VYKLLAEDWPFGVEMCKLVPFIQKASVGITVLSLCALSI 96
                        90       100       110
                ....*....|....*....|....*....|....*..
gi 84370345 138 DRYWSITRHLEYTLRTRKRVSNVMILLTWALSTVISL 174
Cdd:cd15976  97 DRYRAVASWSRIKGIGVPKWTAVEIVLIWVVSIILAV 133
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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