|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
13-384 |
6.23e-123 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 361.15 E-value: 6.23e-123
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112363088 13 IIILTYVLAALELTCLFMQFSILPYLSRTLGLDSVSFGYLQTTFGVLQLLGGPVFGRFADQCGARAALSLSFLAASALYL 92
Cdd:cd17331 1 VLLIVHLNIVLYATCYWLQQPVLPYLTKKLGVDSVVFGYLQTTFSVLQLVGGPLFGRFGDLFGPRAALVLSFLSSALSYL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112363088 93 LLVASCSpalpgVFLLFASRIPSALMHTLPAAQMVITDLTAPTERPAALGRLGLCFGIGIIFGSLLGGTLNTAYGIQCPA 172
Cdd:cd17331 81 LLAFASS-----VPMLFLSRLPSVFMHAMQAAQMVVTDLTDPGERAAALGRLGLSYGIGMVVGSFLGGLLTKKFGEQAAA 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112363088 173 ILAFVVTLLGAVLSFTCVPATTKEASVQSAPQGGTKASVFDLKAITRLLLLPRVLPVFLVKVISGLPSGLFLVMFSIISM 252
Cdd:cd17331 156 LVAAVGSLLSIVLVILLIPSNTKSKREKEAKESASPPSVFNLKEILRLLRLPGVAFLLLVKLLSGLPIGMFQSMFSLVAM 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112363088 253 DFFQLEAAQAGYLMSFFGILQMMIQGLVIGRLSTHFPEEALLRSSVLVFAVVGLGMALMSSVLHFCFLMPGLVFSLCTLN 332
Cdd:cd17331 236 DFFGLTPEENGYLMSYAGVLGMVVQGLLVGPLTKRFGERSLLKLSVALLAIGYLLLAFVTTVWQLLVLLLPLVIGGSVLY 315
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 112363088 333 VVTDSMLTKAVSASDTGTMLGLSASVQPLTRTLGPTLGGLLYRSYGVPIFGH 384
Cdd:cd17331 316 TVITSLLTKAVPPEDTGTALGLSHALFSLVRTVSPTIGGALLQAYGFPSFGL 367
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
18-378 |
2.54e-47 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 165.06 E-value: 2.54e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112363088 18 YVLAALELTCLFMQFSILPYLSR---TLGLDSVSFGYLQTTFGVLQLLGGPVFGRFADQCGARAALSLSFLAASALYLLL 94
Cdd:cd17330 2 FLVVFLDALGFGIVFPVLPFYVRefnKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112363088 95 VASCSPAlpgvFLLFASRIPSALMHTLPAAQMVITDLTAPTERPAALGRLGLCFGIGIIFGSLLGGTLNTAYGIQCPAIL 174
Cdd:cd17330 82 GLSRNLW----LLFLARFLDGLTGGNVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLV 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112363088 175 AFVVTLLGAVLSFTCVPattkeasvqsapqggtkasvfdlkaitrllllpRVLPVFLVKVISGLPSGLFLVMFSIISMDF 254
Cdd:cd17330 158 AAALALLNLVLVLFFLP---------------------------------PLRRLLLVYFLIALAFAGLESVFSLFLKDR 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112363088 255 FQLEAAQAGYLMSFFGILQMMIQGLVIGRLSTHFPEEALLRSSVLVFAVVGLGMALMSSVLHFCFLMPGLVFSLCTLNVV 334
Cdd:cd17330 205 FGFSPSQIGLLLALVGIAGILAQLLLIPRLAKRLGERKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPA 284
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 112363088 335 TDSMLTKAVSASDTGTMLGLSASVQPLTRTLGPTLGGLLYRSYG 378
Cdd:cd17330 285 LSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLG 328
|
|
| MFS_MFSD9 |
cd17390 |
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ... |
18-374 |
8.76e-33 |
|
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340948 [Multi-domain] Cd Length: 350 Bit Score: 126.19 E-value: 8.76e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112363088 18 YVLAALELTCLFMQFSILPYLSRTLGLDSVSFGYLQTTFGVLQLLGGPVFGRFADQCGARAALSLSFLAASALYLLLVAS 97
Cdd:cd17390 2 YLVGFLDLFGVSMILPLLSTHIRSLGASPTVIGLIGSVYGALQLFSSPLVGSWSDVVGRRPVLLICLLLTALGYVLLGFS 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112363088 98 CSpalpgVFLLFASRIPSALM-HTLPAAQMVITDLTAPTERPAALGRLGLCFGIGIIFGSLLGGTL-NTAYGIQCPAILA 175
Cdd:cd17390 82 TS-----LALLFLSRIPLGIFkHTQSLCKAYLSDLVSEQERSRVLGRFNAASSLGFILGPVVGGHLaETDGGFYYVALLC 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112363088 176 FVVTLLGAVLSFTCVPattkeasvqsapqggtkaSVFDLkaitrllllprvlpvFLVKVISGLPSGLFLVMFSIISMDFF 255
Cdd:cd17390 157 SAIFILNAGLVWFLLS------------------KLWDL---------------LLVRFLMGFSVLLFRSNFSLYLEERF 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112363088 256 QLEAAQAGYLMSFFGILQMmIQGLVIGRLSTHFPEE---ALLRSSVLVFAVVgLGMALMSSVLHFCFLMPGLVFSLCTLN 332
Cdd:cd17390 204 DLSPKTIGYLISYSGVLGA-LSGFLVGRILKLYKNNeylLLLHSFILLALSL-LGLALAPSIWLLVLCLTPLSISSAVLR 281
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 112363088 333 VVTDSMLTKAVSASDTGTMLGLSASVQPLTRTLGPTLGGLLY 374
Cdd:cd17390 282 TCSTSLLLSRGKSKERGTLLGVGQSVTSLARILAPLLSGLLQ 323
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
18-380 |
3.49e-23 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 99.96 E-value: 3.49e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112363088 18 YVLAALELTCLFMQFSILPYLSRTLGLDSVSFGYLQTTFGVLQLLGGPVFGRFADQCGARAALSLSFLAASALYLLLVAS 97
Cdd:cd17325 2 SLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112363088 98 CSPALPgVFLLFASRIPSALmhTLPAAQMVITDLTAPTERPAALGRLGLCFGIGIIFGSLLGGTLNTAYGIQCPAILAFV 177
Cdd:cd17325 82 TSYWQL-LLARFLQGLASAA--VWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112363088 178 VTLLGAVLSFTCVPATTKEASVQSAPQGGTKASVFDLkaitrlLLLPRVLPVFLVKVISGLPSGLFLVMFSIISMDFFQL 257
Cdd:cd17325 159 LALLALVLALLLLPEPRPPPNKRAVSAARLRSGLRLL------LRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGL 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112363088 258 EAAQAGYLMSFFGILQMMIQGLViGRLSTHFPEEALLRSSVLVFAVVGLGMALMSSVLHFCFLMPGLVFSLCTLNVVTDS 337
Cdd:cd17325 233 SPAQIGLLFGAQGLASALSQPPA-GKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLA 311
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 112363088 338 MLTKAVSASDTGTMLGLSASVQPLTRTLGPTLGGLLYRSYGVP 380
Cdd:cd17325 312 LLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFA 354
|
|
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
12-374 |
2.04e-19 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 89.23 E-value: 2.04e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112363088 12 GIIILTYVLAALELTcLFMqfSILPYLSRTLGLDSVS----FGYLQTTFGVLQLLGGPVFGRFADQCGARAALSLSflAA 87
Cdd:cd17388 2 IFILVTVLLDAMGIG-LIM--PVLPTLLREFVGDSADaathYGVLLALYALMQFIFAPILGALSDRFGRRPVLLLS--LA 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112363088 88 SALYLLLVASCSPALPgvfLLFASRIPSALM-HTLPAAQMVITDLTAPTERPAALGRLGLCFGIGIIFGSLLGGTLNtAY 166
Cdd:cd17388 77 GAALDYLLMAFAPTLW---WLYLGRIIAGITgATGAVAAAYIADVTPPEQRARNFGLLGAAFGLGFIAGPALGGLLG-EI 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112363088 167 GIQCPAILAFVVTLLGAVLSFTCVPATTKEASVQSAPQGGTKAsvfdlkaitrlllLPRVLPVFLVKVISGLPSGLFLVM 246
Cdd:cd17388 153 SPRAPFLVAAGLNGLNFLLGLFVLPESLPPERRRAFRWRRANP-------------FGSLRWLTGFPGLLGLLAVFFLIQ 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112363088 247 ---------FSIISMDFFQLEAAQAGYLMSFFGILQMMIQGLVIGRLSTHFPEEallRSSVLVFAVVGLGMALMSSVLHF 317
Cdd:cd17388 220 ligqvpattWVLFTEDRFDWSPTMVGLSLAVFGLLHALFQAFVTGPIAKRLGEK---RAILLGLAADALGFLLLAFATQG 296
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 112363088 318 CFLMPGLVFsLCTLNVVT---DSMLTKAVSASDTGTMLGLSASVQPLTRTLGPTLGGLLY 374
Cdd:cd17388 297 WMVFPILIL-LALGGIAGpalQGLLSRQVPENEQGELQGVLTSLTSLTSIIGPLLFTGIF 355
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
4-359 |
9.92e-19 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 86.57 E-value: 9.92e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112363088 4 SMAALPRQGIIILTYVLAALELTCLFMQFSILPYLSRTLGLDSVSFGYLQTTFGVLQLLGGPVFGRFADQCGARAALSLS 83
Cdd:COG2814 2 PATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112363088 84 FLAASALYLLLVAScspalPGVFLLFASRIPSALMHTL--PAAQMVITDLTAPTERPAALGRLGLCFGIGIIFGSLLGGT 161
Cdd:COG2814 82 LLLFALGSLLCALA-----PSLWLLLAARFLQGLGAGAlfPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGL 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112363088 162 LNTAYGIQCPAILAFVVTLLGAVLSFTCVPATTKEASVQsapqggtkasvfDLKAITRLLLLPRVLPVFLVKVISGLPSG 241
Cdd:COG2814 157 LADLFGWRWVFLVNAVLALLALLLLLRLLPESRPAARAR------------LRGSLRELLRRPRLLLLLLLAFLLGFGFF 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112363088 242 LFLVMFSIISMDFFQLEAAQAGYLMSFFGILqMMIQGLVIGRLSTHFPEEALLRSSVLVFAVVGLGMALMSSVLHFCFLM 321
Cdd:COG2814 225 ALFTYLPLYLQEVLGLSASAAGLLLALFGLG-GVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLAL 303
|
330 340 350
....*....|....*....|....*....|....*...
gi 112363088 322 PGLVFSLCTLNVVTDSMLTKAVSASDTGTMLGLSASVQ 359
Cdd:COG2814 304 FLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAF 341
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
14-367 |
5.38e-15 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 75.53 E-value: 5.38e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112363088 14 IILTYVLAALELTCLFmqFSILPYLSRTLGLDSVSFGYLQTTFGVLQLLGGPVFGRFADQCGARAALSLSFLAASALYLL 93
Cdd:pfam07690 1 LFLAAFLAALGRSLLG--PALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112363088 94 LVAScspalPGVFLLFASRIPSALMH--TLPAAQMVITDLTAPTERPAALGRLGLCFGIGIIFGSLLGGTLNTAYGIQCP 171
Cdd:pfam07690 79 LLFA-----SSLWLLLVLRVLQGLGAgaLFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAA 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112363088 172 AILAFVVTLLGAVLSFtcVPATTKEASVQSAPQGGTKASVFDLKAITRLLLLPRVLPVFLVKVISGLpsglfLVMFSIIS 251
Cdd:pfam07690 154 FLILAILSLLAAVLLL--LPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFG-----LLTYLPLY 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112363088 252 MDFFQLEAAQAGYLMSFFGILqMMIQGLVIGRLSTHFPEEALLRSSVLVFAVVGLGMALMSSVLHFCFLMPGLV---FSL 328
Cdd:pfam07690 227 QEVLGLSALLAGLLLGLGGLL-GAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLllgFGF 305
|
330 340 350
....*....|....*....|....*....|....*....
gi 112363088 329 CTLNVVTDSMLTKAVSASDTGTMLGLSASVQPLTRTLGP 367
Cdd:pfam07690 306 GLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
18-374 |
3.38e-11 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 64.37 E-value: 3.38e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112363088 18 YVLAALELTCLFMQFSILPYLSRTLGLDSVSFGYLQTTFGVLQLLGGPVFGRFADQCGARAALSLSFlaaSALYLLLVAS 97
Cdd:cd06174 2 LLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGL---LLFALGALLF 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112363088 98 CSPALPGVFLLFASRIPSALMHTLPAAQMVITDLTAPTERPAALGRLGLCFGIGIIFGSLLGGTLNTAYGIQCPAilAFV 177
Cdd:cd06174 79 AFAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRA--VFL 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112363088 178 VTLLGAVLSFTCVPATTKEASVQSAPQGGTKASVFDLKAITRLLLLPRVLPVFLVKVISGLPSGLFLVMFSIISMDFFQL 257
Cdd:cd06174 157 IAAALALLAAILLLLVVPDPPESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGL 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112363088 258 EAAQAGYLMSFFGILQMMIQGLVIGRLSTHFPEEALLRSSVLVFAVVGLGMALMSSVLHFCFLMPGLVFSLCTLNVVTDS 337
Cdd:cd06174 237 SVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFA 316
|
330 340 350
....*....|....*....|....*....|....*..
gi 112363088 338 MLTKAVSASDTGTMLGLSASVQPLTRTLGPTLGGLLY 374
Cdd:cd06174 317 LIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLL 353
|
|
| MFS_MFSD10 |
cd17389 |
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ... |
45-378 |
2.14e-10 |
|
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340947 [Multi-domain] Cd Length: 391 Bit Score: 61.91 E-value: 2.14e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112363088 45 DSVSFG-YLQTTFGVLQLLGGPVFGRFADQCGARAALSLSFLAASALYLLLVASCSPalpGVFLLfaSRIPSALMH-TLP 122
Cdd:cd17389 61 NSVLFGgLIGSLFSLLQFLSSPITGAASDVYGRKPVLLLTMIGLAISYALWAVSRSF---TIFLL--SRIVGGISKgNVS 135
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112363088 123 AAQMVITDLTAPTERPAALGRLGLCFGIGIIFGSLLGG---TLNTAYGI---QCPAILAFVVTLLGAVLSFTCVPATTKE 196
Cdd:cd17389 136 LSTAIVADVTSPKKRSKGMALIGVAFSLGFIIGPMIGAyfaSFTRSLGEvffSMPALFALVLALADLLFIFFFLPETLPS 215
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112363088 197 AsvqsapqggtkasvfdlkaitrllllprvlpvflVKVIsGLPSGLFLVMFS-------IISMDFFQLEAAQAGYLMSFF 269
Cdd:cd17389 216 N----------------------------------LRRL-GLVYFLYLFLFSgleftltFLTHQRFQYTSMQQGKMFFFI 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112363088 270 GILQMMIQGLVIGRLSTHFPEEALLRSSVLVF-AVVGLGMALMSSVLHFCFLMpglvFSLCTLNVVT--DSMLTKAVSAS 346
Cdd:cd17389 261 GIIMALVQGGYVRRIKPGKEKKAVLQGLILLIpAFLLIGWASSVTVLYAGLFL----YSFAAATVVPclTTLVSGYGSDD 336
|
330 340 350
....*....|....*....|....*....|..
gi 112363088 347 DTGTMLGLSASVQPLTRTLGPTLGGLLYRSYG 378
Cdd:cd17389 337 QKGTVMGIFRSLGALARALGPIVACTVYWLAG 368
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
30-381 |
7.11e-10 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 60.32 E-value: 7.11e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112363088 30 MQFSILPYLSRTLGLDSVSFGYLQTTFGVLQLLGGPVFGRFADQCGARAALSLSFLAASALYLLLVASCSPALPGVFLLF 109
Cdd:cd06173 17 IFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLALLGSLSLWLLL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112363088 110 ASRIPSALMHTL--PAAQMVITDLTAPTERPAALGRLGLCFGIGIIFGSLLGGTLNTAYGIQCPAILAFVVTLLGAVLSF 187
Cdd:cd06173 97 VLAFLLGIASAFfgPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALSFLLSALLLL 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112363088 188 TCVPATTKEASVQSAPQGGtkasvFDLKAITRLLLLPRVLPVFLVKVISGLPSGLFLVMFSIISMDFFQLEAAQAGYLMS 267
Cdd:cd06173 177 FIRRPPPAAPGESSSLLLR-----DLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLA 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112363088 268 FFGIlQMMIQGLVIGRLSTHFPEEALLRSSVLVFAVVGLGMALMSSVLHFCFLMPGLVFSLCTLNVVTDSMLTKAVSASD 347
Cdd:cd06173 252 AFGV-GALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDEL 330
|
330 340 350
....*....|....*....|....*....|....
gi 112363088 348 TGTMLGLSASVQPLTRTLGPTLGGLLYRSYGVPI 381
Cdd:cd06173 331 RGRVFSVYNALNSGAMPLGALLAGLLADALGLSA 364
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
37-378 |
6.40e-09 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 57.24 E-value: 6.40e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112363088 37 YLSRTLGLDSVSFGYLQTTFGVLQLLGGPVFGRFADQCGARAALSLSFLAASALYLLLVASCSPALPGVFLLFASrIPSA 116
Cdd:cd17329 25 YLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTG-FGGG 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112363088 117 LMHtlPAAQMVITDLTAPTERPAALGRLGLCFGIGIIFGSLLGGTLnTAYGIQCPAILAFVVTLLGAVLSFTCVPAT-TK 195
Cdd:cd17329 104 LFE--PASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLL-LLYSFRLLFLAAAVLFLLAALVLLFLLPETrPK 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112363088 196 EASVQSAPQGGTKASVFDLKAITrllllprvlPVFLVKVISGLPSGLFLVMFSIISMDFFQLEAAQAGYLMSFFGILQMM 275
Cdd:cd17329 181 RRAAEKTEILRGYKIVLRDRAFL---------LFLLASFLISLIYFQLESTLPVYVVEILGLGESLLGLLLALNALLIVL 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112363088 276 IQGLVIgRLSTHFPEEALLRSSVLVFAV----VGLGMALMSSVLHFCFLMPGLVFSLCTLNVVTDSMltkaVSASDTGTM 351
Cdd:cd17329 252 LQFPVA-RLVERFRLRKILMIGILLFAIgfavLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAAL----APPDKRGSY 326
|
330 340
....*....|....*....|....*..
gi 112363088 352 LGLSASVQPLTRTLGPTLGGLLYRSYG 378
Cdd:cd17329 327 MGFYALAWGLGRAIGPLVGGLLLDLLG 353
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
34-378 |
5.34e-08 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 54.50 E-value: 5.34e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112363088 34 ILPYLSRTLGLDSVSFGYLQTTFGVLQLLGGPVFGRFADQCGARAALSLSFLAAsalylllvascspALPGVFLLFASRI 113
Cdd:cd17474 21 ILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLF-------------GIGGLLCGLSDSF 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112363088 114 PSALM----------HTLPAAQMVITDLTAPTERPAALGRLGLCFGIGIIFGSLLGGTLnTAYGIQCPAILAFVVTLLGA 183
Cdd:cd17474 88 ALLLAgralqgigaaGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLL-AAISWRYPFFLLAALIPVAF 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112363088 184 VLSFTCVPATTKEASVQSAPQGGTKASVFDLKAITRLLLLPRVLPVFLvkvisglpsGLFLVMFSIISMDFFQLEAAQAG 263
Cdd:cd17474 167 LAILFLLPEPKEKAKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLY---------FAFLTYLPFLLELLYGISPIIIG 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112363088 264 YLMSFFGILqMMIQGLVIGRLSTH-FPEEALLRSSVLVFAVVGLGMALMSSVLhfCFLMPGLVFSLC--TLNVVTDSMLT 340
Cdd:cd17474 238 LLFAGWSVL-LALGSLFVGRLLKKrFGARRILVIGLLLYALSLLLLGFVPSLA--LLLIAIVLFGLGlgLNLPLLTTLVT 314
|
330 340 350
....*....|....*....|....*....|....*...
gi 112363088 341 KAVSASDTGTMLGLSASVQPLTRTLGPTLGGLLYRSYG 378
Cdd:cd17474 315 ELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFG 352
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
34-378 |
1.25e-07 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 53.34 E-value: 1.25e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112363088 34 ILPYLSRTLGLDSVSFGYLQTTFGVLQLLGGPVFGRFADQCGARAALSLSFLAASALYLLLVAScspalPGVFLLFASRI 113
Cdd:COG2271 32 AAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFA-----TSFWQLLLLRF 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112363088 114 PSALMH--TLPAAQMVITDLTAPTERPAALGRLGLCFGIGIIFGSLLGGTLNTAYGIQCPAILAFVVTLLGAVLSFTCVp 191
Cdd:COG2271 107 LLGLGEagFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILGLPGLLLALLRFWLL- 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112363088 192 attkeasvqsapqggtkasvfdlkaitrllllprvlpvFLVKVISGLPSGLFLVMFSIISMDFFQLEAAQAGYLMSFFGI 271
Cdd:COG2271 186 --------------------------------------ALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFL 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112363088 272 LqMMIQGLVIGRLSTHFPEE--ALLRSSVLVFAVVGLGMALMSSVLHFCFLMPGLVFSLCTLNVVTDSMLTKAVSASDTG 349
Cdd:COG2271 228 A-GIVGSLLGGWLSDRLGRRrkLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARG 306
|
330 340
....*....|....*....|....*....
gi 112363088 350 TMLGLSASVQPLTRTLGPTLGGLLYRSYG 378
Cdd:COG2271 307 TASGLVNTFGFLGGALGPLLVGYLLDATG 335
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
29-378 |
5.73e-07 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 51.03 E-value: 5.73e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112363088 29 FMQFSIL-PYLSRTLGLDSVSFGYLQTTFGVLQLLGGPVFGRFADQCGARAALSLSFLAAsalylllvascspALPGVFL 107
Cdd:COG2223 21 WYLWSVLaPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLL-------------GIGLLLL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112363088 108 LFASRIPSALMH----------TLPAAQMVITDLTAPTERPAALGRLGLCFGIGIIFGSLLGGTLNTAYGIQCPAILAFV 177
Cdd:COG2223 88 ALAVSYWLLLLLglllgiggggSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGI 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112363088 178 VTLLGAVLSFTCVPATTKEASVQSapqggtKASVFDLKAITRLLLLPRVLPVFLVKVISGLPsglFLVMFSIISMDFFQL 257
Cdd:COG2223 168 LLLVVAVLAWLFLRDPPAGAAAAA------KASLRDQLEALRDPRFWLLSLLYFGTFGSFIG---FSSWLPPYLVDQFGL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112363088 258 EAAQAGYLMSFFGILQMMIqGLVIGRLSTHFPEEALLrssVLVFAVVGLGMALMSSVLH--FCFLMPGLVFSLCT--LNV 333
Cdd:COG2223 239 SAATAGLLAALFALLGALG-RPLGGWLSDRIGGRRVL---LIVFALMALGLLLLALALGslWLFLVLFLLLGLALggGNG 314
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 112363088 334 VTDSMLTKAVSASDTGTMLGLSASVQPLTRTLGPTLGGLLYRSYG 378
Cdd:COG2223 315 AVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATG 359
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
30-382 |
8.45e-07 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 50.65 E-value: 8.45e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112363088 30 MQFSILPYLSRTLGLDSVSFGYLQTTFGVLQLLGGPVFGRFADQCGARAALSLSFLAASALYLLLVAScsPALPgvFLLF 109
Cdd:cd17504 14 MLSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFA--PNLP--VLIA 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112363088 110 ASRIPSALMHTLPAAQMVITDLTAPTERPAALGRLGLCFGIGIIFGSLLGGTLNTAYGIQcpaiLAFVVTLLGAVLSFTC 189
Cdd:cd17504 90 GRALQGIGGAVFPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWR----WIFWTAAPVAVLLAAL 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112363088 190 VPattkeasvqsapqggtkasVFDLKAITRLLLLPRVLPVFLVKVISGLPSGLFLVMFSIISMDFFQLEAAQAGYLMSFF 269
Cdd:cd17504 166 VP-------------------LIDLRLLRRRNVLLANITALLAGFGMFMVFQLLPQLLQLPTPTGFGLGITEAGLLLLPG 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112363088 270 GILqMMIQGLVIGRLSTHFPEEALLRSSVLVFAVVGLGMALMSSVLHFCFLMPGLV---FSLCTLNVVTdsMLTKAVSAS 346
Cdd:cd17504 227 ALV-MLIAGPLAGRLIARVGPRRVLLIGLVISAVGLLLLALLHSSLWALVVALLLIgigLGLAFASLPN--IVVESVPPD 303
|
330 340 350
....*....|....*....|....*....|....*.
gi 112363088 347 DTGTMLGLSASVQPLTRTLGPTLGGLLYRSYGVPIF 382
Cdd:cd17504 304 RTGIATGMNTVLRTIGSAIGPAIAGAILTTYTVSIT 339
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
128-378 |
5.23e-06 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 48.36 E-value: 5.23e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112363088 128 ITDLTA-PTERPAALGRLGLCFGIGIIFGSLLGGTLNTAYGIQCPA---ILAFVVTLLGAVLSFTCVpATTKEASVQSAP 203
Cdd:COG2211 135 GAELTPdYEERTRLSSWRFAFAGLGGLLASVLPPPLVAAFGGDAALgyrLTALIFAVLGLLAFLLTF-FGTKERPVPEEE 213
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112363088 204 QGGTKASVFDLKAITRLLLLprvlpvFLVKVISGLPSGLFLVMFSIISMDFFQLEAAQAGYLMSFFGILQMMIQgLVIGR 283
Cdd:COG2211 214 KVSLKESLKALLKNRPFLLL------LLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGA-PLWPR 286
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112363088 284 LSTHFPEEALLRSSVLVFAVVGLGMALM--SSVLHFCFLMPGLVFSLCTLNVVTDSMLTKAVSASD-------TGTMLGL 354
Cdd:COG2211 287 LAKRFGKKKAFIIGLLLAALGLLLLFFLgpGNLWLLLVLAALAGIGLGAILVLPWAMLADVVDYDEwktgrrrEGLYFGI 366
|
250 260
....*....|....*....|....
gi 112363088 355 SASVQPLTRTLGPTLGGLLYRSYG 378
Cdd:COG2211 367 FTFAIKLGQALAGALAGLLLALFG 390
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
2-284 |
7.38e-06 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 47.50 E-value: 7.38e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112363088 2 SGSMAALPRQGIIILTYVLAALELTCLFMQFSILPYLSRTLGLDSVSFGYLQTTFGVLQLLGGPVFGRFADQCGARAALS 81
Cdd:COG0477 4 TDAAPTRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112363088 82 LSFLAASALYLllvasCSPALPGVFLLFASRIPSALMHTL--PAAQMVITDLTAPTERPAALGRLGLCFGIGIIFGSLLG 159
Cdd:COG0477 84 IGLLLFGLASL-----LCGLAPSPELLIAARALQGIGAGGlmPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLG 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112363088 160 GTLNTAYGIQCPAILAFVVTLLGAVLSFTCV-PATTKEASVQSAPQGGTKASVFDLKAITRLLLLPRVLPVFLVKVISGL 238
Cdd:COG0477 159 GLLVAALGWRWIFLINAPLGLLALVLRLRLPeSRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAA 238
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 112363088 239 PSGLFLVMFSIISMDFFQLEAAQAGYLMSFFGILQMMIQGLVIGRL 284
Cdd:COG0477 239 LLLLLALLLLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLL 284
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
29-381 |
9.07e-06 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 47.20 E-value: 9.07e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112363088 29 FMQFSILPYLSRTLGLDSVSFGYLQTTFGVLQLLGGPVFGRFADQCGARAALSLSFLAASALYLLLVAScspalPGVFLL 108
Cdd:cd17489 13 YLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLA-----TSVALL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112363088 109 FASRIPSALMH--TLPAAQMVITDLTAPTERPAALGRLGLCFGIGIIFGSLLGGTLNTAYGIQCPAILAFVVTLLGAVLS 186
Cdd:cd17489 88 LVLRLIHGIGWgaFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALLLV 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112363088 187 FTcVPATTKEASVQSAPQGGTKASVFDLKAitrllllprvlpvFLVKVISGLPSGLFLVMFSIISMDFFQLEAAQAGYLM 266
Cdd:cd17489 168 FL-VKDPPPVAAEEAEAGTRAFRRLVEKKV-------------LPPALILFLASIAYGAISTFLPLYAAERGISNAGLFF 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112363088 267 SFFGILqMMIQGLVIGRLSTHFPEEALLRSSVLVFAVVGLGMALMSSVLHF--CFLMPGLVFSLctLNVVTDSMLTKAVS 344
Cdd:cd17489 234 TVYAIA-LLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLllAAVLYGLGFGL--LFPALQALAVDLVP 310
|
330 340 350
....*....|....*....|....*....|....*..
gi 112363088 345 ASDTGTMLGLSASVQPLTRTLGPTLGGLLYRSYGVPI 381
Cdd:cd17489 311 PHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRA 347
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
33-313 |
1.44e-05 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 46.77 E-value: 1.44e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112363088 33 SILPYLSRTLGLDSVSFGYLQTTFGVLQLLGGPVFGRFADQCGARAALSLSFLAASALYLLLVAScspalPGVFLLFASR 112
Cdd:COG0738 29 PLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALA-----PSYPLLLLAL 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112363088 113 IPSALMHTL--PAAQMVITDLTaPTERPAALGRLGLCFGIGIIFGSLLGGTL---NTAYGIQCP-AILAFVVTLLGAVLS 186
Cdd:COG0738 104 FLLGLGLGLldVAANPYVAALG-PETAASRLNLLHAFFSLGALLGPLLGGLLillGLSLSWHLPyLILAVLLLLLALLFL 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112363088 187 FTCVPATTKEASvQSAPQGGTKASVFDLKAItrllllprvLPVFLVKVISGLPSGLFLVMFSIISMDFFQLEAAQAGYLM 266
Cdd:COG0738 183 RSKLPEIEEEEE-EAAGSAASLKSLLKNPRL---------LLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGL 252
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 112363088 267 SFFGILqMMIQGLVIGRLSTHFPEEALLRSSvLVFAVVGLGMALMSS 313
Cdd:COG0738 253 SLFWGG-MTIGRFLGGFLLKRFGPVRLLRLS-ALLAAVGLLLALLAP 297
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
3-187 |
4.06e-05 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 45.23 E-value: 4.06e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112363088 3 GSMAALPRQGIIILTYVLAALELTCLFMQFSIL-PYLSRTLGLDSVSFGYLQTTFGVLQLLGGPVFGRFADQCGARAALS 81
Cdd:cd17324 189 SSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLaPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLI 268
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112363088 82 LSFLAASALYLLLVASCSP--ALPGVFLLFAsripsALMHTLPAAQMVITDLtAPTERPAALGRLGLCFGIGIIFGSLLG 159
Cdd:cd17324 269 ALLLLAAALLLLTLLGPSPllLLVGLVLWGL-----GFFAAHSALQTRVLRL-APEARGLASSLYLAAYNLGGALGAALG 342
|
170 180
....*....|....*....|....*...
gi 112363088 160 GTLNTAYGIQCPAILAFVVTLLGAVLSF 187
Cdd:cd17324 343 GLVLDHGGWAGVGWVGAALLLLALLLAL 370
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
28-380 |
5.68e-05 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 44.85 E-value: 5.68e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112363088 28 LFMQFSILPYLSRTLGLDSVSFGYLQTTFGVLQLLGGPVFGRFADQCGARAALSLSFLAASALYLllvasCSPALPGVFL 107
Cdd:cd17324 15 EYVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNL-----LAALAPSFAL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112363088 108 LFASRIPSALMHTL--PAAQMVITDLTAPTERPAALGRLGLCFGIGIIFGSLLGGTLNTAYGIQCPAILAFVVTLLGAVL 185
Cdd:cd17324 90 LLLARALAGLAHGGfwAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112363088 186 SFTCVPATTKEASVQSAPQGGTKASVFDLKAitrllllprvlpvFLVKVISGLPSGLFLVMFSIIS---MDFFQLEAAQA 262
Cdd:cd17324 170 LWRLLPSLPPKKPGSLGLLSSLLLLLRNPRL-------------RLAYLITFLLFGGFFALYTYLApflTDVPGFSSSAI 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112363088 263 GYLMSFFGILqMMIQGLVIGRLSTHFPEEALLrSSVLVFAVVGLGMALMSSVLHFCFLMPGLVFSLCTLNVVTDSMLTKA 342
Cdd:cd17324 237 IGLLLLFGVA-GVVGSPLAGRLADRGGRRALL-IALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLR 314
|
330 340 350
....*....|....*....|....*....|....*...
gi 112363088 343 VSASDTGTMLGLSASVQPLTRTLGPTLGGLLYRSYGVP 380
Cdd:cd17324 315 LAPEARGLASSLYLAAYNLGGALGAALGGLVLDHGGWA 352
|
|
| MFS_MFSD8 |
cd17326 |
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) ... |
13-378 |
6.92e-05 |
|
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) domain-containing protein 8 (MFSD8) is also called ceroid-lipofuscinosis neuronal protein 7 (CLN7). It is a polytopic lysosomal membrane protein that may transport small solutes by using chemiosmotic ion gradients. Mutations in MFSD8/CLN7 cause a variant of late-infantile neuronal ceroid lipofuscinoses (vLINCL), a neurodegenerative lysosomal storage disorder. Some variants are associated with nonsyndromic autosomal recessive macular dystrophy. MFSD8/CLN7 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340884 [Multi-domain] Cd Length: 374 Bit Score: 44.51 E-value: 6.92e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112363088 13 IIILTYVLAALELTCLFMqfSILPYLSR-TLGLDSVSFGYLQTTFGVLQLLGGPVFGRFADQCG-ARAALSLSFLAASAL 90
Cdd:cd17326 3 VMYLTMFLSSLQFSIVLT--SIWPYLQKiDPTATASFFGWVVAAYSLGQLVFSPVFGYWSNKTSsVKEPLIVSILIAIVG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112363088 91 YLLLVASCSPALPGVFLLFASRIPSAL-MHTLPAAQMVITDLTAPTERPAALGRLGLCFGIGIIFGSLLGGTLNTA---- 165
Cdd:cd17326 81 NILYALAEYFPSNRKYVMLVARFLIGVgAGNVAVLRAYVAAASTLKDRTRAMAVISAAQALGFIVGPALQAAFTPIgypg 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112363088 166 YGIQC---------PAILAFVVTLLGAVLSFTCVpattKEASVqsapqggtkasvfdlkaitrllllprvlpvFLVKVIS 236
Cdd:cd17326 161 YVIGIklrfnmytaPAWLMAILGIINIILILFFF----KEVVC------------------------------IFLFFVV 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112363088 237 GLPSGLFLVMFSIISMDFFQLEAAQA----GYLMSFFGILQmMIQGLVIGRLSTHFPEEALLRSSVLVFAVVGLgmaLMS 312
Cdd:cd17326 207 LFIFANLETIGTPLTMDMYGWTREEAvlynGIILAVSGVLS-VLVFLLFKFLSLGLIDERKILLGGLILFFLGF---VVT 282
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 112363088 313 SVLHFCFlmpGLVFSLC--TLNVVTDSMLTKAVSASDTGTMLGLSASVQPLTRTLGPTLGGLLYRSYG 378
Cdd:cd17326 283 LPWGITG---VILFGLGypIGNVMLYTLYSKILGPKPQGTMQGVLTASGSLARTLGPIFVTAIYTHFG 347
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
13-195 |
1.99e-04 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 43.32 E-value: 1.99e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112363088 13 IIILTYVLAALELTCLFMQFSIL----PYLSRTLGLDSVSFGYLQTTFGVLQLLGGPVFGRFADQCGARAALSLSFLAAS 88
Cdd:COG2271 178 ALLRFWLLALAYFLVYFALYGFLtwlpTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLL 257
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112363088 89 ALYLLLVASCSPALPGVFLLFAsrIPSALMH-TLPAAQMVITDLTAPTERPAALGRLGLCFGIGIIFGSLLGGTLNTAYG 167
Cdd:COG2271 258 AALALLLLALLPSPALAIALLF--LAGFGLGgAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATG 335
|
170 180
....*....|....*....|....*...
gi 112363088 168 IQCPAILAFVVTLLGAVLSFTCVPATTK 195
Cdd:COG2271 336 YQAAFLLLAALALLAALLALLLLRETRK 363
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
230-378 |
1.17e-03 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 40.73 E-value: 1.17e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112363088 230 FLVKVISGLPSGLFLVMFSIISMDFfQLEAAQAGYLMSFFGILQMMIQgLVIGRLSTHFPEEALLRSSVLVFAVVGLGMA 309
Cdd:COG2814 16 ALGAFLSGLGIGIVLPALPLIAADL-GASPAQAGLVVTAYLLGAALGA-PLAGRLADRFGRRRVLLLGLLLFALGSLLCA 93
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 112363088 310 LMSSVLHFCFLMPGLVFSLCTLNVVTDSMLTKAVSASDTGTMLGLSASVQPLTRTLGPTLGGLLYRSYG 378
Cdd:COG2814 94 LAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFG 162
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
230-378 |
1.60e-03 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 40.48 E-value: 1.60e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112363088 230 FLVKVISGLPSGLFLVMFSIISMDFFQLEAAQAGYLMSFFGILQMMIQgLVIGRLSTHFPEEALLRSSVLVFAVVGLGMA 309
Cdd:pfam07690 2 FLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQ-PLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 112363088 310 LMSSVLHFCFLMPGLVFSLCTLNVVTDSMLTKAVSASDTGTMLGLSASVQPLTRTLGPTLGGLLYRSYG 378
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFG 149
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
33-217 |
1.67e-03 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 40.30 E-value: 1.67e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112363088 33 SILPYLSRTLGLDSVSFGYLQTTFGVLQLLGGPVFGRFADQCGARAALSLSFLAASALYLLlvascSPALPGVFLLFASR 112
Cdd:cd17328 20 GVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLL-----SSFAPNFWQLLLFR 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112363088 113 IPSALMHTL--PAAQMVITDLTAPTERPAALGRLGLCFGIGIIFGSLLGGTLNTA-YGIQCPAILAFVVTLLGAVLSFTC 189
Cdd:cd17328 95 ALVGIGEASysPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQAtGGWRWAFRVTGVLGVLLAILLLLF 174
|
170 180
....*....|....*....|....*....
gi 112363088 190 VPATTKEASVQSAPQGGTKASVF-DLKAI 217
Cdd:cd17328 175 VREPPRGAAEGGVMAKSTATSFLaDLKAL 203
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
128-379 |
2.15e-03 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 39.89 E-value: 2.15e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112363088 128 ITDLTAPTERPAALGRLGLCFGIGIIFGSLLGGTLNTAYGIQCPAILAFVVTLLGAVLSFTCVPATTKEASVQSAPQGGT 207
Cdd:cd17472 108 LADLTREENRTKAMALIGASIGIAFAISMVLGPLLAAHLGVSGLFLITAILSLVSLLILLFFVPDPPKIVQISEKEKKKL 187
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112363088 208 KASVFDLKaitrllllprvlpVFLVKVISGLPSGLFLVMFSIISMDFFQLEAAQAGYLMSFfgiLQMMIQGLVIGRLSTH 287
Cdd:cd17472 188 KKLLKNKR-------------LLRLDFSIFILHFVLMAFFYILPLLLTQLGGGKGQLWKVY---LPAILIGFILMVPFVI 251
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112363088 288 FPEEALLRSSVLVFAVVGLGMA---LMSSVLHFCFLMPGLVF---SLCTLNVVTDSMLTKAVSASDTGTMLGLSASVQPL 361
Cdd:cd17472 252 YAEKKGKMKQVFVSSILLIAVGfllLLFAATSLWLLIIGLIIffiGFNLLEALLPSLVSKIAPKEYRGTAMGIYNTSQFL 331
|
250
....*....|....*...
gi 112363088 362 TRTLGPTLGGLLYRSYGV 379
Cdd:cd17472 332 GSFLGGALGGLLWGLLGY 349
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
10-188 |
2.60e-03 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 39.52 E-value: 2.60e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112363088 10 RQGIIILTYVLAALELTCLFMQFSILPYLSR-TLGLDSVSFGYLQTTFGVLQLLGGPVFGRFADQCGARAALSLSFLAAS 88
Cdd:cd06173 206 RSPLLRLLLLALALFALLGGALTVLLPLLAKeVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLG 285
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112363088 89 ALYLLLVASCSPALPGVFLLFASripSALMHTLPAAQMVITDLTAPTERPAALGRLGLCFGIGIIFGSLLGGTLNTAYGI 168
Cdd:cd06173 286 LALLVLGLSPSLWLLLAALFLLG---LAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGL 362
|
170 180
....*....|....*....|
gi 112363088 169 QCPAILAFVVTLLGAVLSFT 188
Cdd:cd06173 363 SAVFLLAGALLLLAALLLLL 382
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
124-381 |
3.23e-03 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 39.48 E-value: 3.23e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112363088 124 AQMVITDLTAPTERPAALGRLGLCFGIGIIFGSLLGGTLNTAYGIQCPAILAFVVTLLGAVLSFTCVPATTKEASVQSAP 203
Cdd:cd17320 108 ARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALLGLLLLLLVLLFLPETLPEEKRKPLL 187
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112363088 204 Q---GGTKASVFDLKAITRLLLLPRVLPVFLVkvisglpsglFLVMFSIISMDFFQLEAAQAGYLMSFFGILqMMIQGLV 280
Cdd:cd17320 188 SsllRAYKRVLKNRRFLGYALALGLSFAGLFA----------YLAAAPFIYIEQLGLSPAQFGLLFALNAIA-LILGSLL 256
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112363088 281 IGRLSTHFPEEALLRSSVLVFAVVGLGMALMSSVLHFCF--LMPGLVFSLCTLNVVTDSMLTKAVSA--SDTGTMLGLSA 356
Cdd:cd17320 257 NGRLVRRFGPRRLLRLGLLLLLAAALVLLLAALLGGLSLwpLVAPLFLIFFGFGLIFPNATSLALEPfpHVAGTASALLG 336
|
250 260
....*....|....*....|....*
gi 112363088 357 SVQPLTRTLGPTLGGLLYRSYGVPI 381
Cdd:cd17320 337 FLQFLIGALAGALVGLLPNGTALPM 361
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
18-378 |
5.71e-03 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 38.69 E-value: 5.71e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112363088 18 YVLAALELTCLFMQFSILPYLSRTLGLDSVSFGYLQTTFGVLQLLGGPVFGRFADQCGARAALSLSFLAASALYLllvas 97
Cdd:cd17477 2 LLSVALLGLGSGLLLPLLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVL----- 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112363088 98 CSPALPGVFLLFASRIPS--ALMHTLPAAQMVITDLTAPTERPAALGRLGLCFGIGIIFGSLLGGTLNTAygIQCPAILA 175
Cdd:cd17477 77 LLALTDSPWVWFLLRFVMgiGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALVGTA--GALPFLIA 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112363088 176 FVVTLLGAV-LSFTCVPATTKEASVqsapqggtkasvfdlkAITRLLLLPRVLPVFLVKVISGLPSGLFLVMFSIISMDf 254
Cdd:cd17477 155 AVLLLLALVpLLLTRRAAPEIEEAE----------------SISLRRLLRIAPLALLGAFVAGFLEGAFYSLLPLYGLR- 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112363088 255 FQLEAAQAGYLMSFFGILQMMIQgLVIGRLSTHFPEEALLRSSVLVFAVVGLGMALMSSVLH----FCFLMPGLVFSLCT 330
Cdd:cd17477 218 LGLSVAQAALLLAAFVLGGLLLQ-WPLGWLADRFDRRRVLLGCALLGALAALLLPLVPGLPLallvLLFLWGGAAGPLYT 296
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 112363088 331 LNVvtdSMLTKAVSASDTGTMLGLSASVQPLTRTLGPTLGGLLYRSYG 378
Cdd:cd17477 297 LAL---ALAGDRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFG 341
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
28-185 |
8.13e-03 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 38.32 E-value: 8.13e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112363088 28 LFMQFSILPYLSRTLGLDSVSFGYLQTTFGVLQLLGGPVFGRFADQCGARAALSLSFLAASALYLLLVASCSPALPGVFL 107
Cdd:COG2223 222 IGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGSLWLFLVL 301
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 112363088 108 LFAsrIPSALMHTLPAAQMVITDLTAPTERPAALGRLGLCFGIGIIFGSLLGGTLNTAYGIQCPAILAFVVTLLGAVL 185
Cdd:COG2223 302 FLL--LGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAFLVFAVLALVALV 377
|
|
| |
