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Conserved domains on  [gi|6678431|ref|NP_033451|]
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tumor necrosis factor ligand superfamily member 10 [Mus musculus]

Protein Classification

TNF domain-containing protein( domain architecture ID 10446394)

TNF domain-containing protein similar to Homo sapiens tumor necrosis factor, which acts as cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
TNF pfam00229
TNF(Tumour Necrosis Factor) family;
157-290 3.23e-53

TNF(Tumour Necrosis Factor) family;


:

Pssm-ID: 425540  Cd Length: 127  Bit Score: 169.80  E-value: 3.23e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678431    157 SWESSRKGHSFLNHVLFRNGELVIEQEGLYYIYSQTYFRFQEAEDASKmvskdkvrtkQLVQYIYKYT-SYPDPIVLMKS 235
Cdd:pfam00229   2 SWESDRGGAFLLNGVTYSNGELVVPQAGLYYVYSQVYFRGEGCPSGSV----------PLTHYLYKFSsSYPGPVLLLKG 71
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 6678431    236 ARNSCWSRDAEYGLYSIYQGGLFELKKNDRIFVSVTNEHLMDLD-QEASFFGAFLI 290
Cdd:pfam00229  72 AESPCSSENPEYWYQSIYLGGLFELRAGDRLSVNVSNPSLVDLSaPGKTYFGAFLL 127
 
Name Accession Description Interval E-value
TNF pfam00229
TNF(Tumour Necrosis Factor) family;
157-290 3.23e-53

TNF(Tumour Necrosis Factor) family;


Pssm-ID: 425540  Cd Length: 127  Bit Score: 169.80  E-value: 3.23e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678431    157 SWESSRKGHSFLNHVLFRNGELVIEQEGLYYIYSQTYFRFQEAEDASKmvskdkvrtkQLVQYIYKYT-SYPDPIVLMKS 235
Cdd:pfam00229   2 SWESDRGGAFLLNGVTYSNGELVVPQAGLYYVYSQVYFRGEGCPSGSV----------PLTHYLYKFSsSYPGPVLLLKG 71
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 6678431    236 ARNSCWSRDAEYGLYSIYQGGLFELKKNDRIFVSVTNEHLMDLD-QEASFFGAFLI 290
Cdd:pfam00229  72 AESPCSSENPEYWYQSIYLGGLFELRAGDRLSVNVSNPSLVDLSaPGKTYFGAFLL 127
TNF cd00184
Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT ...
126-288 3.79e-46

Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT (lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL), Fas ligand, and osteoprotegerin (OPG) ligand. These proteins generally have an intracellular N-terminal domain, a short transmembrane segment, an extracellular stalk, and a globular TNF-like extracellular domain of about 150 residues. They initiate apoptosis by binding to related receptors, some of which have intracellular death domains. They generally form homo- or hetero- trimeric complexes.TNF cytokines bind one elongated receptor molecule along each of three clefts formed by neighboring monomers of the trimer with ligand trimerization a requiste for receptor binding.


Pssm-ID: 238108  Cd Length: 137  Bit Score: 151.73  E-value: 3.79e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678431  126 VAAHITGITRRSnsalipiskdgktlGQKIESWESSRkGHSFLNHVL-FRNGELVIEQEGLYYIYSQTYFRFQEAedask 204
Cdd:cd00184   1 PAAHLIGTNSSS--------------GGTGLSWESDD-GRAFLSGGLeLQNGELVVPQDGLYYIYSQVYFRGQCC----- 60
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678431  205 mvskdkvRTKQLVQYIYKYT-SYPDPIVLMKSARNSCWSRdAEYGLYSIYQGGLFELKKNDRIFVSVTNEHLMDLDQEAS 283
Cdd:cd00184  61 -------STLSVSHVLQLRTdSYPEPILLLKGIRSVCSSV-SEGWYNSVYLGGLFQLRAGDRLSVNVSAPALLDLSQGTT 132

                ....*
gi 6678431  284 FFGAF 288
Cdd:cd00184 133 FFGAF 137
TNF smart00207
Tumour necrosis factor family; Family of cytokines that form homotrimeric or heterotrimeric ...
157-289 1.67e-37

Tumour necrosis factor family; Family of cytokines that form homotrimeric or heterotrimeric complexes. TNF mediates mature T-cell receptor-induced apoptosis through the p75 TNF receptor.


Pssm-ID: 214557  Cd Length: 125  Bit Score: 129.39  E-value: 1.67e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678431     157 SWESSRKGHSFLNHVLFRNGELVIEQEGLYYIYSQTYFRFQEAEDASKMVSkdkvrtkqlVQYIYKYTSYPDPIVLMKSA 236
Cdd:smart00207   2 SWESDRGLASLLSGMELQNGELVVPRDGLYYIYSQVYFRGQGCNGKSVELS---------LSLHLRKPSYPLPLLLLEAA 72
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 6678431     237 RNSCWSRDAEYgLYSIYQGGLFELKKNDRIFVSVTNEHLMDLDQEASFFGAFL 289
Cdd:smart00207  73 RSSCWSASSAW-KDSVYLGGLFPLTAGDRLSVNVTEPSLVDLAPGATFFGAFL 124
 
Name Accession Description Interval E-value
TNF pfam00229
TNF(Tumour Necrosis Factor) family;
157-290 3.23e-53

TNF(Tumour Necrosis Factor) family;


Pssm-ID: 425540  Cd Length: 127  Bit Score: 169.80  E-value: 3.23e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678431    157 SWESSRKGHSFLNHVLFRNGELVIEQEGLYYIYSQTYFRFQEAEDASKmvskdkvrtkQLVQYIYKYT-SYPDPIVLMKS 235
Cdd:pfam00229   2 SWESDRGGAFLLNGVTYSNGELVVPQAGLYYVYSQVYFRGEGCPSGSV----------PLTHYLYKFSsSYPGPVLLLKG 71
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 6678431    236 ARNSCWSRDAEYGLYSIYQGGLFELKKNDRIFVSVTNEHLMDLD-QEASFFGAFLI 290
Cdd:pfam00229  72 AESPCSSENPEYWYQSIYLGGLFELRAGDRLSVNVSNPSLVDLSaPGKTYFGAFLL 127
TNF cd00184
Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT ...
126-288 3.79e-46

Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT (lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL), Fas ligand, and osteoprotegerin (OPG) ligand. These proteins generally have an intracellular N-terminal domain, a short transmembrane segment, an extracellular stalk, and a globular TNF-like extracellular domain of about 150 residues. They initiate apoptosis by binding to related receptors, some of which have intracellular death domains. They generally form homo- or hetero- trimeric complexes.TNF cytokines bind one elongated receptor molecule along each of three clefts formed by neighboring monomers of the trimer with ligand trimerization a requiste for receptor binding.


Pssm-ID: 238108  Cd Length: 137  Bit Score: 151.73  E-value: 3.79e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678431  126 VAAHITGITRRSnsalipiskdgktlGQKIESWESSRkGHSFLNHVL-FRNGELVIEQEGLYYIYSQTYFRFQEAedask 204
Cdd:cd00184   1 PAAHLIGTNSSS--------------GGTGLSWESDD-GRAFLSGGLeLQNGELVVPQDGLYYIYSQVYFRGQCC----- 60
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678431  205 mvskdkvRTKQLVQYIYKYT-SYPDPIVLMKSARNSCWSRdAEYGLYSIYQGGLFELKKNDRIFVSVTNEHLMDLDQEAS 283
Cdd:cd00184  61 -------STLSVSHVLQLRTdSYPEPILLLKGIRSVCSSV-SEGWYNSVYLGGLFQLRAGDRLSVNVSAPALLDLSQGTT 132

                ....*
gi 6678431  284 FFGAF 288
Cdd:cd00184 133 FFGAF 137
TNF smart00207
Tumour necrosis factor family; Family of cytokines that form homotrimeric or heterotrimeric ...
157-289 1.67e-37

Tumour necrosis factor family; Family of cytokines that form homotrimeric or heterotrimeric complexes. TNF mediates mature T-cell receptor-induced apoptosis through the p75 TNF receptor.


Pssm-ID: 214557  Cd Length: 125  Bit Score: 129.39  E-value: 1.67e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678431     157 SWESSRKGHSFLNHVLFRNGELVIEQEGLYYIYSQTYFRFQEAEDASKMVSkdkvrtkqlVQYIYKYTSYPDPIVLMKSA 236
Cdd:smart00207   2 SWESDRGLASLLSGMELQNGELVVPRDGLYYIYSQVYFRGQGCNGKSVELS---------LSLHLRKPSYPLPLLLLEAA 72
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 6678431     237 RNSCWSRDAEYgLYSIYQGGLFELKKNDRIFVSVTNEHLMDLDQEASFFGAFL 289
Cdd:smart00207  73 RSSCWSASSAW-KDSVYLGGLFPLTAGDRLSVNVTEPSLVDLAPGATFFGAFL 124
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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