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Conserved domains on  [gi|1579876405|ref|NP_034087|]
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protocadherin alpha-7 precursor [Mus musculus]

Protein Classification

protocadherin( domain architecture ID 11175747)

protocadherin is a transmembrane protein belonging to the cadherin superfamily and may be a calcium-dependent cell-adhesion protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cadherin_tail pfam15974
Cadherin C-terminal cytoplasmic tail, catenin-binding region; Cadherin_tail is the cytoplasmic ...
 796-912 6.52e-70

Cadherin C-terminal cytoplasmic tail, catenin-binding region; Cadherin_tail is the cytoplasmic domain at the C-terminus of cadherin proteins. This domain binds p120 catenin, an action critical for the surface stability of cadherin-catenin cell-cell adhesion complexes.


:

Pssm-ID: 435046  Cd Length: 134  Bit Score: 227.98  E-value: 6.52e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1579876405 796 RQPNPDWRYSASLRAG-MHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQ 874
Cdd:pfam15974   1 KPPNPDWRYSASLRAGpMQSSVHMEEAGVLRGGPGGLEQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFRYGPGNPKQ 80

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1579876405 875 SGPGELPDKFIIPGSPAIISIRQEPANNQiDKSDFITF 912
Cdd:pfam15974  81 PVPGEYPENFIIPGSPAIISIRQPQAQTQ-DQSDFITF 117
Cadherin_2 pfam08266
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.
 39-120 1.59e-35

Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.


:

Pssm-ID: 462413  Cd Length: 83  Bit Score: 129.18  E-value: 1.59e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1579876405  39 QLHYSVPEEAKHGTFVGRIAQDLGLELTELVPRLFRVASKDRGDLLEVNLQNGILFVNSRIDREELCGRSAECSIHLEVI 118
Cdd:pfam08266   1 QIRYSVPEETERGSFVGNLAKDLGLEVGELAARGARVVSKGNKQYFQLNPETGDLLLNEKLDREELCGSTEPCVLHFQVL 80


                  ..
gi 1579876405 119 VD 120
Cdd:pfam08266  81 LE 82
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 256-355 5.33e-31

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 117.03  E-value: 5.33e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1579876405 256 YTVKLPENVPNGTLVIKVNASDLDEGVNGDVMYSFssdVSSDIKSKFHMDTVSGEITVIGIIDFEESKAYKIPLEARDKG 335
Cdd:cd11304     2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSI---VSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG 78

                          90       100
                  ....*....|....*....|
gi 1579876405 336 FPQLPGHCTILVEVVDANDN 355
Cdd:cd11304    79 GPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 468-570 5.38e-28

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 108.55  E-value: 5.38e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1579876405 468 EYTVFVKENNPPGAHIFTVSAMDADAQENALVSYSLVERRVgerllSSYVSVHAESGKVFALQPLDHEELELLQFQVSAR 547
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNE-----DGLFSIDPSTGEITTAKPLDREEQSSYTLTVTAT 75

                          90       100
                  ....*....|....*....|...
gi 1579876405 548 DAGVPALGSNVTLQVFVLDENDN 570
Cdd:cd11304    76 DGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 363-460 5.32e-26

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 102.78  E-value: 5.32e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1579876405 363 SLSLPVSEDSQPGRVVTLISVFDRDSGANGQVTCSLTPHIPFKLVSTFKNYYSLVLDSALDRETIANYDVIVTARDGGSP 442
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                          90
                  ....*....|....*...
gi 1579876405 443 SLWATASVSVEVADVNDN 460
Cdd:cd11304    81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 149-247 1.84e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 89.68  E-value: 1.84e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1579876405 149 LFILESRLLDSRFPLEGASDADVGSNALLTYRLS---TNEHFSLDvPPNHEqvkplgLVLRKPLDREEAAEIRLLLTATD 225
Cdd:cd11304     4 VSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVsgnEDGLFSID-PSTGE------ITTAKPLDREEQSSYTLTVTATD 76

                          90       100
                  ....*....|....*....|..
gi 1579876405 226 GGKPELTGTVQLLITVLDVNDN 247
Cdd:cd11304    77 GGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 590-680 3.91e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 80.44  E-value: 3.91e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1579876405 590 VSRALVPGQVVAKVRAVDEDSGYNAWLSFELqpVAGGVRSPFRVGLYTGEISTTRAL--EETDALRqcLLVLVKDHGEPS 667
Cdd:cd11304     6 VPENAPPGTVVLTVSATDPDSGENGEVTYSI--VSGNEDGLFSIDPSTGEITTAKPLdrEEQSSYT--LTVTATDGGGPP 81

                          90
                  ....*....|...
gi 1579876405 668 LTATATVLLSLVD 680
Cdd:cd11304    82 LSSTATVTITVLD 94
 
Name Accession Description Interval E-value
Cadherin_tail pfam15974
Cadherin C-terminal cytoplasmic tail, catenin-binding region; Cadherin_tail is the cytoplasmic ...
 796-912 6.52e-70

Cadherin C-terminal cytoplasmic tail, catenin-binding region; Cadherin_tail is the cytoplasmic domain at the C-terminus of cadherin proteins. This domain binds p120 catenin, an action critical for the surface stability of cadherin-catenin cell-cell adhesion complexes.


Pssm-ID: 435046  Cd Length: 134  Bit Score: 227.98  E-value: 6.52e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1579876405 796 RQPNPDWRYSASLRAG-MHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQ 874
Cdd:pfam15974   1 KPPNPDWRYSASLRAGpMQSSVHMEEAGVLRGGPGGLEQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFRYGPGNPKQ 80

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1579876405 875 SGPGELPDKFIIPGSPAIISIRQEPANNQiDKSDFITF 912
Cdd:pfam15974  81 PVPGEYPENFIIPGSPAIISIRQPQAQTQ-DQSDFITF 117
Cadherin_2 pfam08266
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.
 39-120 1.59e-35

Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.


Pssm-ID: 462413  Cd Length: 83  Bit Score: 129.18  E-value: 1.59e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1579876405  39 QLHYSVPEEAKHGTFVGRIAQDLGLELTELVPRLFRVASKDRGDLLEVNLQNGILFVNSRIDREELCGRSAECSIHLEVI 118
Cdd:pfam08266   1 QIRYSVPEETERGSFVGNLAKDLGLEVGELAARGARVVSKGNKQYFQLNPETGDLLLNEKLDREELCGSTEPCVLHFQVL 80


                  ..
gi 1579876405 119 VD 120
Cdd:pfam08266  81 LE 82
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 256-355 5.33e-31

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 117.03  E-value: 5.33e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1579876405 256 YTVKLPENVPNGTLVIKVNASDLDEGVNGDVMYSFssdVSSDIKSKFHMDTVSGEITVIGIIDFEESKAYKIPLEARDKG 335
Cdd:cd11304     2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSI---VSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG 78

                          90       100
                  ....*....|....*....|
gi 1579876405 336 FPQLPGHCTILVEVVDANDN 355
Cdd:cd11304    79 GPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 468-570 5.38e-28

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 108.55  E-value: 5.38e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1579876405 468 EYTVFVKENNPPGAHIFTVSAMDADAQENALVSYSLVERRVgerllSSYVSVHAESGKVFALQPLDHEELELLQFQVSAR 547
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNE-----DGLFSIDPSTGEITTAKPLDREEQSSYTLTVTAT 75

                          90       100
                  ....*....|....*....|...
gi 1579876405 548 DAGVPALGSNVTLQVFVLDENDN 570
Cdd:cd11304    76 DGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 363-460 5.32e-26

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 102.78  E-value: 5.32e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1579876405 363 SLSLPVSEDSQPGRVVTLISVFDRDSGANGQVTCSLTPHIPFKLVSTFKNYYSLVLDSALDRETIANYDVIVTARDGGSP 442
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                          90
                  ....*....|....*...
gi 1579876405 443 SLWATASVSVEVADVNDN 460
Cdd:cd11304    81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 149-247 1.84e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 89.68  E-value: 1.84e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1579876405 149 LFILESRLLDSRFPLEGASDADVGSNALLTYRLS---TNEHFSLDvPPNHEqvkplgLVLRKPLDREEAAEIRLLLTATD 225
Cdd:cd11304     4 VSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVsgnEDGLFSID-PSTGE------ITTAKPLDREEQSSYTLTVTATD 76

                          90       100
                  ....*....|....*....|..
gi 1579876405 226 GGKPELTGTVQLLITVLDVNDN 247
Cdd:cd11304    77 GGGPPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 274-357 2.87e-21

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 88.56  E-value: 2.87e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1579876405  274 NASDLDEGVNGDVMYSFssdVSSDIKSKFHMDTVSGEITVIGIIDFEESKAYKIPLEARDKGFPQLPGHCTILVEVVDAN 353
Cdd:smart00112   1 SATDADSGENGKVTYSI---LSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVN 77


                   ....
gi 1579876405  354 DNAP 357
Cdd:smart00112  78 DNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 166-249 3.71e-20

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 85.48  E-value: 3.71e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1579876405  166 ASDADVGSNALLTYRLS---TNEHFSLDvpPNHEQVkplglVLRKPLDREEAAEIRLLLTATDGGKPELTGTVQLLITVL 242
Cdd:smart00112   2 ATDADSGENGKVTYSILsgnDDGLFSID--PETGEI-----TTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVL 74


                   ....*..
gi 1579876405  243 DVNDNAP 249
Cdd:smart00112  75 DVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 487-572 7.49e-20

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 84.71  E-value: 7.49e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1579876405  487 SAMDADAQENALVSYSLVERRVGerllsSYVSVHAESGKVFALQPLDHEELELLQFQVSARDAGVPALGSNVTLQVFVLD 566
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDD-----GLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLD 75


                   ....*.
gi 1579876405  567 ENDNAP 572
Cdd:smart00112  76 VNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 382-462 1.29e-19

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 83.94  E-value: 1.29e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1579876405  382 SVFDRDSGANGQVTCSLTPHIPFKLVSTFKNYYSLVLDSALDRETIANYDVIVTARDGGSPSLWATASVSVEVADVNDNA 461
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                   .
gi 1579876405  462 P 462
Cdd:smart00112  81 P 81
Cadherin pfam00028
Cadherin domain;
256-349 3.11e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 80.42  E-value: 3.11e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1579876405 256 YTVKLPENVPNGTLVIKVNASDLDEGVNGDVMYSFSSDVSSDIkskFHMDTVSGEITVIGIIDFEESKAYKIPLEARDKG 335
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGN---FRIDPDTGDISTTKPLDRESIGEYELTVEATDSG 77

                          90
                  ....*....|....
gi 1579876405 336 FPQLPGHCTILVEV 349
Cdd:pfam00028  78 GPPLSSTATVTITV 91
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 590-680 3.91e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 80.44  E-value: 3.91e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1579876405 590 VSRALVPGQVVAKVRAVDEDSGYNAWLSFELqpVAGGVRSPFRVGLYTGEISTTRAL--EETDALRqcLLVLVKDHGEPS 667
Cdd:cd11304     6 VPENAPPGTVVLTVSATDPDSGENGEVTYSI--VSGNEDGLFSIDPSTGEITTAKPLdrEEQSSYT--LTVTATDGGGPP 81

                          90
                  ....*....|...
gi 1579876405 668 LTATATVLLSLVD 680
Cdd:cd11304    82 LSSTATVTITVLD 94
Cadherin pfam00028
Cadherin domain;
469-565 1.95e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 69.64  E-value: 1.95e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1579876405 469 YTVFVKENNPPGAHIFTVSAMDADAQENALVSYSLVERRVGERLlssyvSVHAESGKVFALQPLDHEELELLQFQVSARD 548
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNF-----RIDPDTGDISTTKPLDRESIGEYELTVEATD 75

                          90
                  ....*....|....*..
gi 1579876405 549 AGVPALGSNVTLQVFVL 565
Cdd:pfam00028  76 SGGPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 604-680 3.14e-12

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 63.14  E-value: 3.14e-12
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1579876405  604 RAVDEDSGYNAWLSFELQPvaGGVRSPFRVGLYTGEISTTRAL--EETDALRqcLLVLVKDHGEPSLTATATVLLSLVD 680
Cdd:smart00112   1 SATDADSGENGKVTYSILS--GNDDGLFSIDPETGEITTTKPLdrEEQPEYT--LTVEATDGGGPPLSSTATVTITVLD 75
Cadherin pfam00028
Cadherin domain;
368-454 4.10e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 63.09  E-value: 4.10e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1579876405 368 VSEDSQPGRVVTLISVFDRDSGANGQVTCSLTPHIPFKLVSTFKNYYSLVLDSALDRETIANYDVIVTARDGGSPSLWAT 447
Cdd:pfam00028   5 VPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPLSST 84


                  ....*..
gi 1579876405 448 ASVSVEV 454
Cdd:pfam00028  85 ATVTITV 91
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 41-138 1.29e-11

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 61.95  E-value: 1.29e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1579876405  41 HYSVPEEAKHGTFVGRI-AQDLGLELTELVprLFRVASKDRGDLLEVNLQNGILFVNSRIDREELcgrsaeCSIHLEVIV 119
Cdd:cd11304     3 EVSVPENAPPGTVVLTVsATDPDSGENGEV--TYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQ------SSYTLTVTA 74

                          90       100
                  ....*....|....*....|....
gi 1579876405 120 -DRPLQVF----HVEVEVKDINDN 138
Cdd:cd11304    75 tDGGGPPLsstaTVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
165-242 3.67e-10

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 57.31  E-value: 3.67e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1579876405 165 GASDADVGSNALLTYRLSTNE---HFSLDVppnheqvKPLGLVLRKPLDREEAAEIRLLLTATDGGKPELTGTVQLLITV 241
Cdd:pfam00028  19 TATDPDLGPNGRIFYSILGGGpggNFRIDP-------DTGDISTTKPLDRESIGEYELTVEATDSGGPPLSSTATVTITV 91


                  .
gi 1579876405 242 L 242
Cdd:pfam00028  92 L 92
Cadherin pfam00028
Cadherin domain;
595-678 6.33e-10

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 56.93  E-value: 6.33e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1579876405 595 VPGQVVAKVRAVDEDSGYNAWLSFELqpVAGGVRSPFRVGLYTGEISTTRAL--EETDALRqcLLVLVKDHGEPSLTATA 672
Cdd:pfam00028  10 PVGTEVLTVTATDPDLGPNGRIFYSI--LGGGPGGNFRIDPDTGDISTTKPLdrESIGEYE--LTVEATDSGGPPLSSTA 85


                  ....*.
gi 1579876405 673 TVLLSL 678
Cdd:pfam00028  86 TVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 73-140 5.75e-06

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 45.03  E-value: 5.75e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1579876405   73 FRVASKDRGDLLEVNLQNGILFVNSRIDREELCgrsaecSIHLEVIV----DRPLQVF-HVEVEVKDINDNPP 140
Cdd:smart00112  15 YSILSGNDDGLFSIDPETGEITTTKPLDREEQP------EYTLTVEAtdggGPPLSSTaTVTITVLDVNDNAP 81
 
Name Accession Description Interval E-value
Cadherin_tail pfam15974
Cadherin C-terminal cytoplasmic tail, catenin-binding region; Cadherin_tail is the cytoplasmic ...
 796-912 6.52e-70

Cadherin C-terminal cytoplasmic tail, catenin-binding region; Cadherin_tail is the cytoplasmic domain at the C-terminus of cadherin proteins. This domain binds p120 catenin, an action critical for the surface stability of cadherin-catenin cell-cell adhesion complexes.


Pssm-ID: 435046  Cd Length: 134  Bit Score: 227.98  E-value: 6.52e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1579876405 796 RQPNPDWRYSASLRAG-MHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQ 874
Cdd:pfam15974   1 KPPNPDWRYSASLRAGpMQSSVHMEEAGVLRGGPGGLEQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFRYGPGNPKQ 80

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1579876405 875 SGPGELPDKFIIPGSPAIISIRQEPANNQiDKSDFITF 912
Cdd:pfam15974  81 PVPGEYPENFIIPGSPAIISIRQPQAQTQ-DQSDFITF 117
Cadherin_2 pfam08266
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.
 39-120 1.59e-35

Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.


Pssm-ID: 462413  Cd Length: 83  Bit Score: 129.18  E-value: 1.59e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1579876405  39 QLHYSVPEEAKHGTFVGRIAQDLGLELTELVPRLFRVASKDRGDLLEVNLQNGILFVNSRIDREELCGRSAECSIHLEVI 118
Cdd:pfam08266   1 QIRYSVPEETERGSFVGNLAKDLGLEVGELAARGARVVSKGNKQYFQLNPETGDLLLNEKLDREELCGSTEPCVLHFQVL 80


                  ..
gi 1579876405 119 VD 120
Cdd:pfam08266  81 LE 82
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 256-355 5.33e-31

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 117.03  E-value: 5.33e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1579876405 256 YTVKLPENVPNGTLVIKVNASDLDEGVNGDVMYSFssdVSSDIKSKFHMDTVSGEITVIGIIDFEESKAYKIPLEARDKG 335
Cdd:cd11304     2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSI---VSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG 78

                          90       100
                  ....*....|....*....|
gi 1579876405 336 FPQLPGHCTILVEVVDANDN 355
Cdd:cd11304    79 GPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 468-570 5.38e-28

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 108.55  E-value: 5.38e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1579876405 468 EYTVFVKENNPPGAHIFTVSAMDADAQENALVSYSLVERRVgerllSSYVSVHAESGKVFALQPLDHEELELLQFQVSAR 547
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNE-----DGLFSIDPSTGEITTAKPLDREEQSSYTLTVTAT 75

                          90       100
                  ....*....|....*....|...
gi 1579876405 548 DAGVPALGSNVTLQVFVLDENDN 570
Cdd:cd11304    76 DGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 363-460 5.32e-26

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 102.78  E-value: 5.32e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1579876405 363 SLSLPVSEDSQPGRVVTLISVFDRDSGANGQVTCSLTPHIPFKLVSTFKNYYSLVLDSALDRETIANYDVIVTARDGGSP 442
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                          90
                  ....*....|....*...
gi 1579876405 443 SLWATASVSVEVADVNDN 460
Cdd:cd11304    81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 149-247 1.84e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 89.68  E-value: 1.84e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1579876405 149 LFILESRLLDSRFPLEGASDADVGSNALLTYRLS---TNEHFSLDvPPNHEqvkplgLVLRKPLDREEAAEIRLLLTATD 225
Cdd:cd11304     4 VSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVsgnEDGLFSID-PSTGE------ITTAKPLDREEQSSYTLTVTATD 76

                          90       100
                  ....*....|....*....|..
gi 1579876405 226 GGKPELTGTVQLLITVLDVNDN 247
Cdd:cd11304    77 GGGPPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 274-357 2.87e-21

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 88.56  E-value: 2.87e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1579876405  274 NASDLDEGVNGDVMYSFssdVSSDIKSKFHMDTVSGEITVIGIIDFEESKAYKIPLEARDKGFPQLPGHCTILVEVVDAN 353
Cdd:smart00112   1 SATDADSGENGKVTYSI---LSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVN 77


                   ....
gi 1579876405  354 DNAP 357
Cdd:smart00112  78 DNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 166-249 3.71e-20

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 85.48  E-value: 3.71e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1579876405  166 ASDADVGSNALLTYRLS---TNEHFSLDvpPNHEQVkplglVLRKPLDREEAAEIRLLLTATDGGKPELTGTVQLLITVL 242
Cdd:smart00112   2 ATDADSGENGKVTYSILsgnDDGLFSID--PETGEI-----TTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVL 74


                   ....*..
gi 1579876405  243 DVNDNAP 249
Cdd:smart00112  75 DVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 487-572 7.49e-20

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 84.71  E-value: 7.49e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1579876405  487 SAMDADAQENALVSYSLVERRVGerllsSYVSVHAESGKVFALQPLDHEELELLQFQVSARDAGVPALGSNVTLQVFVLD 566
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDD-----GLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLD 75


                   ....*.
gi 1579876405  567 ENDNAP 572
Cdd:smart00112  76 VNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 382-462 1.29e-19

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 83.94  E-value: 1.29e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1579876405  382 SVFDRDSGANGQVTCSLTPHIPFKLVSTFKNYYSLVLDSALDRETIANYDVIVTARDGGSPSLWATASVSVEVADVNDNA 461
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                   .
gi 1579876405  462 P 462
Cdd:smart00112  81 P 81
Cadherin pfam00028
Cadherin domain;
256-349 3.11e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 80.42  E-value: 3.11e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1579876405 256 YTVKLPENVPNGTLVIKVNASDLDEGVNGDVMYSFSSDVSSDIkskFHMDTVSGEITVIGIIDFEESKAYKIPLEARDKG 335
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGN---FRIDPDTGDISTTKPLDRESIGEYELTVEATDSG 77

                          90
                  ....*....|....
gi 1579876405 336 FPQLPGHCTILVEV 349
Cdd:pfam00028  78 GPPLSSTATVTITV 91
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 590-680 3.91e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 80.44  E-value: 3.91e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1579876405 590 VSRALVPGQVVAKVRAVDEDSGYNAWLSFELqpVAGGVRSPFRVGLYTGEISTTRAL--EETDALRqcLLVLVKDHGEPS 667
Cdd:cd11304     6 VPENAPPGTVVLTVSATDPDSGENGEVTYSI--VSGNEDGLFSIDPSTGEITTAKPLdrEEQSSYT--LTVTATDGGGPP 81

                          90
                  ....*....|...
gi 1579876405 668 LTATATVLLSLVD 680
Cdd:cd11304    82 LSSTATVTITVLD 94
Cadherin pfam00028
Cadherin domain;
469-565 1.95e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 69.64  E-value: 1.95e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1579876405 469 YTVFVKENNPPGAHIFTVSAMDADAQENALVSYSLVERRVGERLlssyvSVHAESGKVFALQPLDHEELELLQFQVSARD 548
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNF-----RIDPDTGDISTTKPLDRESIGEYELTVEATD 75

                          90
                  ....*....|....*..
gi 1579876405 549 AGVPALGSNVTLQVFVL 565
Cdd:pfam00028  76 SGGPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 604-680 3.14e-12

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 63.14  E-value: 3.14e-12
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1579876405  604 RAVDEDSGYNAWLSFELQPvaGGVRSPFRVGLYTGEISTTRAL--EETDALRqcLLVLVKDHGEPSLTATATVLLSLVD 680
Cdd:smart00112   1 SATDADSGENGKVTYSILS--GNDDGLFSIDPETGEITTTKPLdrEEQPEYT--LTVEATDGGGPPLSSTATVTITVLD 75
Cadherin pfam00028
Cadherin domain;
368-454 4.10e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 63.09  E-value: 4.10e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1579876405 368 VSEDSQPGRVVTLISVFDRDSGANGQVTCSLTPHIPFKLVSTFKNYYSLVLDSALDRETIANYDVIVTARDGGSPSLWAT 447
Cdd:pfam00028   5 VPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPLSST 84


                  ....*..
gi 1579876405 448 ASVSVEV 454
Cdd:pfam00028  85 ATVTITV 91
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 41-138 1.29e-11

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 61.95  E-value: 1.29e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1579876405  41 HYSVPEEAKHGTFVGRI-AQDLGLELTELVprLFRVASKDRGDLLEVNLQNGILFVNSRIDREELcgrsaeCSIHLEVIV 119
Cdd:cd11304     3 EVSVPENAPPGTVVLTVsATDPDSGENGEV--TYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQ------SSYTLTVTA 74

                          90       100
                  ....*....|....*....|....
gi 1579876405 120 -DRPLQVF----HVEVEVKDINDN 138
Cdd:cd11304    75 tDGGGPPLsstaTVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
165-242 3.67e-10

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 57.31  E-value: 3.67e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1579876405 165 GASDADVGSNALLTYRLSTNE---HFSLDVppnheqvKPLGLVLRKPLDREEAAEIRLLLTATDGGKPELTGTVQLLITV 241
Cdd:pfam00028  19 TATDPDLGPNGRIFYSILGGGpggNFRIDP-------DTGDISTTKPLDRESIGEYELTVEATDSGGPPLSSTATVTITV 91


                  .
gi 1579876405 242 L 242
Cdd:pfam00028  92 L 92
Cadherin pfam00028
Cadherin domain;
595-678 6.33e-10

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 56.93  E-value: 6.33e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1579876405 595 VPGQVVAKVRAVDEDSGYNAWLSFELqpVAGGVRSPFRVGLYTGEISTTRAL--EETDALRqcLLVLVKDHGEPSLTATA 672
Cdd:pfam00028  10 PVGTEVLTVTATDPDLGPNGRIFYSI--LGGGPGGNFRIDPDTGDISTTKPLdrESIGEYE--LTVEATDSGGPPLSSTA 85


                  ....*.
gi 1579876405 673 TVLLSL 678
Cdd:pfam00028  86 TVTITV 91
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 42-138 5.14e-06

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 45.80  E-value: 5.14e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1579876405  42 YSVPEEAKHGTFVGRIAQDLGLELTELVPRLFRVASKDRGdLLEVNLQNGILFVNSRIDREELcgrsaeCSIHLEVIVDR 121
Cdd:cd00031     4 GSAVEGRSRGSFRVSIPTDLIASSGEIIKISAAGKEALPS-WLHWEPHSGILEGLEKLDREDK------GVHYISVSAAS 76

                          90       100
                  ....*....|....*....|..
gi 1579876405 122 -----PLQVFHVEVEVKDINDN 138
Cdd:cd00031    77 lganvPQTSSVFSIEVYDENDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 73-140 5.75e-06

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 45.03  E-value: 5.75e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1579876405   73 FRVASKDRGDLLEVNLQNGILFVNSRIDREELCgrsaecSIHLEVIV----DRPLQVF-HVEVEVKDINDNPP 140
Cdd:smart00112  15 YSILSGNDDGLFSIDPETGEITTTKPLDREEQP------EYTLTVEAtdggGPPLSSTaTVTITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
41-142 7.29e-04

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 39.59  E-value: 7.29e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1579876405  41 HYSVPEEAKHGTFVGRI-AQDLGLELTELVprLFRVASKDRGDLLEVNLQNGILFVNSRIDREElcgrsaecsihleviv 119
Cdd:pfam00028   2 SASVPENAPVGTEVLTVtATDPDLGPNGRI--FYSILGGGPGGNFRIDPDTGDISTTKPLDRES---------------- 63

                          90       100
                  ....*....|....*....|...
gi 1579876405 120 drpLQVFHVEVEVKDiNDNPPMF 142
Cdd:pfam00028  64 ---IGEYELTVEATD-SGGPPLS 82
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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