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Conserved domains on  [gi|6753832|ref|NP_034316|]
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high affinity immunoglobulin gamma Fc receptor I precursor [Mus musculus]

Protein Classification

Ig1_FcgammaR_like and Ig2_FcgammaR_like domain-containing protein( domain architecture ID 10146250)

protein containing domains Ig1_FcgammaR_like, Ig2_FcgammaR_like, and ig

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ig2_FcgammaR_like cd05753
Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains; ...
 114-194 5.18e-35

Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains; The members here are composed of the second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs). Interactions between IgG and FcgammaR are important to the initiation of cellular and humoral response. IgG binding to FcgammaR leads to a cascade of signals and ultimately to functions such as antibody-dependent-cellular-cytotoxicity (ADCC), endocytosis, phagocytosis, release of inflammatory mediators, etc. FcgammaR has two Ig-like domains. This group also contains FcepsilonRI which binds IgE with high affinity.


:

Pssm-ID: 409411  Cd Length: 83  Bit Score: 123.95  E-value: 5.18e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753832  114 WLLLQASRRVLTEGEPLALRCHGWKNKLVYNVVFYRNGKSFQFS-SDSEVAILKTNLSHSGIYHCSGTGR-HRYTSAGVS 191
Cdd:cd05753   1 WLLLQAPSAVVFEGEPLTLRCHGWKDKKVHKVTYYKDGKALKFSyENSNFSIPQATLSDSGSYHCSGTVRiKRRSSESVN 80


                ...
gi 6753832  192 ITV 194
Cdd:cd05753  81 ITV 83
Ig1_FcgammaR_like cd05752
First immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains; ...
 32-110 1.32e-34

First immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains; The members here are composed of the first immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs). Interactions between IgG and FcgammaR are important to the initiation of cellular and humoral response. IgG binding to FcgammaR leads to a cascade of signals and ultimately to functions such as antibody-dependent-cellular-cytotoxicity (ADCC), endocytosis, phagocytosis, release of inflammatory mediators, etc. FcgammaR has two Ig-like domains. This group also contains FcepsilonRI which binds IgE with high affinity.


:

Pssm-ID: 409410 [Multi-domain]  Cd Length: 79  Bit Score: 122.86  E-value: 1.32e-34
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6753832   32 AVITLQPPWVSIFQKENVTLWCEGPHLPGDSSTQWFINGTAVQISTPSYSIPEASFQDSGEYRCQIGSSMPSDPVQLQI 110
Cdd:cd05752   1 AVVSLDPPWTTVFQGEKVTLTCQGFYSPEQNSTQWYHNGTLISSTSSSYRIVAATVNDSGEYRCQTQGSSLSDPVHLEV 79
ig pfam00047
Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of ...
 205-283 5.41e-10

Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies, the giant muscle kinase titin and receptor tyrosine kinases. Immunoglobulin-like domains may be involved in protein-protein and protein-ligand interactions.


:

Pssm-ID: 395002  Cd Length: 86  Bit Score: 55.66  E-value: 5.41e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753832    205 ASVSSPFPEGSLVTLNCETNLllQRPGLQLHFSFYVGSKIL-------EYRNTSSEYHIARAEREDAGFYWCEVATEDSS 277
Cdd:pfam00047   2 APPTVTVLEGDSATLTCSAST--GSPGPDVTWSKEGGTLIEslkvkhdNGRTTQSSLLISNVTKEDAGTYTCVVNNPGGS 79


                  ....*.
gi 6753832    278 VLKRSP 283
Cdd:pfam00047  80 ATLSTS 85
 
Name Accession Description Interval E-value
Ig2_FcgammaR_like cd05753
Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains; ...
 114-194 5.18e-35

Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains; The members here are composed of the second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs). Interactions between IgG and FcgammaR are important to the initiation of cellular and humoral response. IgG binding to FcgammaR leads to a cascade of signals and ultimately to functions such as antibody-dependent-cellular-cytotoxicity (ADCC), endocytosis, phagocytosis, release of inflammatory mediators, etc. FcgammaR has two Ig-like domains. This group also contains FcepsilonRI which binds IgE with high affinity.


Pssm-ID: 409411  Cd Length: 83  Bit Score: 123.95  E-value: 5.18e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753832  114 WLLLQASRRVLTEGEPLALRCHGWKNKLVYNVVFYRNGKSFQFS-SDSEVAILKTNLSHSGIYHCSGTGR-HRYTSAGVS 191
Cdd:cd05753   1 WLLLQAPSAVVFEGEPLTLRCHGWKDKKVHKVTYYKDGKALKFSyENSNFSIPQATLSDSGSYHCSGTVRiKRRSSESVN 80


                ...
gi 6753832  192 ITV 194
Cdd:cd05753  81 ITV 83
Ig1_FcgammaR_like cd05752
First immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains; ...
 32-110 1.32e-34

First immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains; The members here are composed of the first immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs). Interactions between IgG and FcgammaR are important to the initiation of cellular and humoral response. IgG binding to FcgammaR leads to a cascade of signals and ultimately to functions such as antibody-dependent-cellular-cytotoxicity (ADCC), endocytosis, phagocytosis, release of inflammatory mediators, etc. FcgammaR has two Ig-like domains. This group also contains FcepsilonRI which binds IgE with high affinity.


Pssm-ID: 409410 [Multi-domain]  Cd Length: 79  Bit Score: 122.86  E-value: 1.32e-34
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6753832   32 AVITLQPPWVSIFQKENVTLWCEGPHLPGDSSTQWFINGTAVQISTPSYSIPEASFQDSGEYRCQIGSSMPSDPVQLQI 110
Cdd:cd05752   1 AVVSLDPPWTTVFQGEKVTLTCQGFYSPEQNSTQWYHNGTLISSTSSSYRIVAATVNDSGEYRCQTQGSSLSDPVHLEV 79
ig pfam00047
Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of ...
 205-283 5.41e-10

Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies, the giant muscle kinase titin and receptor tyrosine kinases. Immunoglobulin-like domains may be involved in protein-protein and protein-ligand interactions.


Pssm-ID: 395002  Cd Length: 86  Bit Score: 55.66  E-value: 5.41e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753832    205 ASVSSPFPEGSLVTLNCETNLllQRPGLQLHFSFYVGSKIL-------EYRNTSSEYHIARAEREDAGFYWCEVATEDSS 277
Cdd:pfam00047   2 APPTVTVLEGDSATLTCSAST--GSPGPDVTWSKEGGTLIEslkvkhdNGRTTQSSLLISNVTKEDAGTYTCVVNNPGGS 79


                  ....*.
gi 6753832    278 VLKRSP 283
Cdd:pfam00047  80 ATLSTS 85
Ig_2 pfam13895
Immunoglobulin domain; This domain contains immunoglobulin-like domains.
 114-194 1.98e-09

Immunoglobulin domain; This domain contains immunoglobulin-like domains.


Pssm-ID: 464026 [Multi-domain]  Cd Length: 79  Bit Score: 53.94  E-value: 1.98e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753832    114 WLLLQASRRVLTEGEPLALRCHGWKNKLVyNVVFYRNGKSfqFSSDSEVAILKTNLSHSGIYHCSGT-GRHRYTSAGVSI 192
Cdd:pfam13895   1 KPVLTPSPTVVTEGEPVTLTCSAPGNPPP-SYTWYKDGSA--ISSSPNFFTLSVSAEDSGTYTCVARnGRGGKVSNPVEL 77


                  ..
gi 6753832    193 TV 194
Cdd:pfam13895  78 TV 79
Ig_2 pfam13895
Immunoglobulin domain; This domain contains immunoglobulin-like domains.
 35-110 1.11e-08

Immunoglobulin domain; This domain contains immunoglobulin-like domains.


Pssm-ID: 464026 [Multi-domain]  Cd Length: 79  Bit Score: 51.63  E-value: 1.11e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6753832     35 TLQPPWVSIFQKENVTLWCEGPHLPGDsSTQWFINGTAVQiSTPSYSIPEASFQDSGEYRCQIG---SSMPSDPVQLQI 110
Cdd:pfam13895   3 VLTPSPTVVTEGEPVTLTCSAPGNPPP-SYTWYKDGSAIS-SSPNFFTLSVSAEDSGTYTCVARngrGGKVSNPVELTV 79
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 213-271 1.23e-03

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 37.48  E-value: 1.23e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 6753832     213 EGSLVTLNCETN------LLLQRPGLQLHFsfYVGSKILEYRNTSSEYHIARAEREDAGFYWCEV 271
Cdd:smart00410   8 EGESVTLSCEASgspppeVTWYKQGGKLLA--ESGRFSVSRSGSTSTLTISNVTPEDSGTYTCAA 70
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 125-194 2.10e-03

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 37.10  E-value: 2.10e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753832     125 TEGEPLALRCHGWKNKlVYNVVFYRNGKS-------FQFSSDSEVAIL---KTNLSHSGIYHCSGTGRHRYTSAGVSITV 194
Cdd:smart00410   7 KEGESVTLSCEASGSP-PPEVTWYKQGGKllaesgrFSVSRSGSTSTLtisNVTPEDSGTYTCAATNSSGSASSGTTLTV 85
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 38-110 3.27e-03

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 36.33  E-value: 3.27e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753832      38 PPWVSIFQKENVTLWCEGPHLPgDSSTQWFINGTAVQISTPSYS-----------IPEASFQDSGEYRCQIGSSMPSD-- 104
Cdd:smart00410   1 PPSVTVKEGESVTLSCEASGSP-PPEVTWYKQGGKLLAESGRFSvsrsgststltISNVTPEDSGTYTCAATNSSGSAss 79


                   ....*.
gi 6753832     105 PVQLQI 110
Cdd:smart00410  80 GTTLTV 85
 
Name Accession Description Interval E-value
Ig2_FcgammaR_like cd05753
Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains; ...
 114-194 5.18e-35

Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains; The members here are composed of the second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs). Interactions between IgG and FcgammaR are important to the initiation of cellular and humoral response. IgG binding to FcgammaR leads to a cascade of signals and ultimately to functions such as antibody-dependent-cellular-cytotoxicity (ADCC), endocytosis, phagocytosis, release of inflammatory mediators, etc. FcgammaR has two Ig-like domains. This group also contains FcepsilonRI which binds IgE with high affinity.


Pssm-ID: 409411  Cd Length: 83  Bit Score: 123.95  E-value: 5.18e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753832  114 WLLLQASRRVLTEGEPLALRCHGWKNKLVYNVVFYRNGKSFQFS-SDSEVAILKTNLSHSGIYHCSGTGR-HRYTSAGVS 191
Cdd:cd05753   1 WLLLQAPSAVVFEGEPLTLRCHGWKDKKVHKVTYYKDGKALKFSyENSNFSIPQATLSDSGSYHCSGTVRiKRRSSESVN 80


                ...
gi 6753832  192 ITV 194
Cdd:cd05753  81 ITV 83
Ig1_FcgammaR_like cd05752
First immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains; ...
 32-110 1.32e-34

First immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains; The members here are composed of the first immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs). Interactions between IgG and FcgammaR are important to the initiation of cellular and humoral response. IgG binding to FcgammaR leads to a cascade of signals and ultimately to functions such as antibody-dependent-cellular-cytotoxicity (ADCC), endocytosis, phagocytosis, release of inflammatory mediators, etc. FcgammaR has two Ig-like domains. This group also contains FcepsilonRI which binds IgE with high affinity.


Pssm-ID: 409410 [Multi-domain]  Cd Length: 79  Bit Score: 122.86  E-value: 1.32e-34
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6753832   32 AVITLQPPWVSIFQKENVTLWCEGPHLPGDSSTQWFINGTAVQISTPSYSIPEASFQDSGEYRCQIGSSMPSDPVQLQI 110
Cdd:cd05752   1 AVVSLDPPWTTVFQGEKVTLTCQGFYSPEQNSTQWYHNGTLISSTSSSYRIVAATVNDSGEYRCQTQGSSLSDPVHLEV 79
ig pfam00047
Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of ...
 205-283 5.41e-10

Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies, the giant muscle kinase titin and receptor tyrosine kinases. Immunoglobulin-like domains may be involved in protein-protein and protein-ligand interactions.


Pssm-ID: 395002  Cd Length: 86  Bit Score: 55.66  E-value: 5.41e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753832    205 ASVSSPFPEGSLVTLNCETNLllQRPGLQLHFSFYVGSKIL-------EYRNTSSEYHIARAEREDAGFYWCEVATEDSS 277
Cdd:pfam00047   2 APPTVTVLEGDSATLTCSAST--GSPGPDVTWSKEGGTLIEslkvkhdNGRTTQSSLLISNVTKEDAGTYTCVVNNPGGS 79


                  ....*.
gi 6753832    278 VLKRSP 283
Cdd:pfam00047  80 ATLSTS 85
Ig_2 pfam13895
Immunoglobulin domain; This domain contains immunoglobulin-like domains.
 114-194 1.98e-09

Immunoglobulin domain; This domain contains immunoglobulin-like domains.


Pssm-ID: 464026 [Multi-domain]  Cd Length: 79  Bit Score: 53.94  E-value: 1.98e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753832    114 WLLLQASRRVLTEGEPLALRCHGWKNKLVyNVVFYRNGKSfqFSSDSEVAILKTNLSHSGIYHCSGT-GRHRYTSAGVSI 192
Cdd:pfam13895   1 KPVLTPSPTVVTEGEPVTLTCSAPGNPPP-SYTWYKDGSA--ISSSPNFFTLSVSAEDSGTYTCVARnGRGGKVSNPVEL 77


                  ..
gi 6753832    193 TV 194
Cdd:pfam13895  78 TV 79
Ig_2 pfam13895
Immunoglobulin domain; This domain contains immunoglobulin-like domains.
 35-110 1.11e-08

Immunoglobulin domain; This domain contains immunoglobulin-like domains.


Pssm-ID: 464026 [Multi-domain]  Cd Length: 79  Bit Score: 51.63  E-value: 1.11e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6753832     35 TLQPPWVSIFQKENVTLWCEGPHLPGDsSTQWFINGTAVQiSTPSYSIPEASFQDSGEYRCQIG---SSMPSDPVQLQI 110
Cdd:pfam13895   3 VLTPSPTVVTEGEPVTLTCSAPGNPPP-SYTWYKDGSAIS-SSPNFFTLSVSAEDSGTYTCVARngrGGKVSNPVELTV 79
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 33-96 1.16e-05

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 43.32  E-value: 1.16e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 6753832     33 VITLQPPWVSIFQKENVTLWCEGPHLPgDSSTQWFINGTA----------VQISTPSYSIPEASFQDSGEYRCQ 96
Cdd:pfam13927   3 VITVSPSSVTVREGETVTLTCEATGSP-PPTITWYKNGEPissgstrsrsLSGSNSTLTISNVTRSDAGTYTCV 75
Ig_2 pfam13895
Immunoglobulin domain; This domain contains immunoglobulin-like domains.
 201-289 3.29e-05

Immunoglobulin domain; This domain contains immunoglobulin-like domains.


Pssm-ID: 464026 [Multi-domain]  Cd Length: 79  Bit Score: 42.00  E-value: 3.29e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753832    201 PVLRASvSSPFPEGSLVTLNCETNlllQRPGLQlhFSFYVGSKILeyrNTSSEYHIARAEREDAGFYWCEVatEDSSVLK 280
Cdd:pfam13895   2 PVLTPS-PTVVTEGEPVTLTCSAP---GNPPPS--YTWYKDGSAI---SSSPNFFTLSVSAEDSGTYTCVA--RNGRGGK 70


                  ....*....
gi 6753832    281 RSPELELQV 289
Cdd:pfam13895  71 VSNPVELTV 79
IgC2_D1_D2_LILR_KIR_like cd16843
Immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors, Natural killer ...
 47-108 5.60e-05

Immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors, Natural killer inhibitory receptors (KIRs) and similar domains; member of Immunoglobulin Constant-2 set of IgSF domains; The members here are composed of the first and second immunoglobulin (Ig)-like domains found in Leukocyte Ig-like receptors (LILRs), Natural killer inhibitory receptors (KIRs, also known as also known as cluster of differentiation (CD) 158), and similar proteins. This group includes LILRB1 (also known as LIR-1), LILRA5 (also known as LIR9), an activating natural cytotoxicity receptor NKp46, the immune-type receptor glycoprotein VI (GPVI), and the IgA-specific receptor Fc-alphaRI (also known as cluster of differentiation (CD) 89). LILRs are a family of immunoreceptors expressed on expressed on T and B cells, on monocytes, dendritic cells, and subgroups of natural killer (NK) cells. The human LILR family contains nine proteins (LILRA1-3, and 5, and LILRB1-5). From functional assays, and as the cytoplasmic domains of various LILRs, for example LILRB1, LILRB2 (also known as LIR-2), and LILRB3 (also known as LIR-3) contain immunoreceptor tyrosine-based inhibitory motifs (ITIMs), it is thought that LIR proteins are inhibitory receptors. Of the eight LIR family proteins, only LILRB1, and LILRB2, show detectable binding to class I MHC molecules; ligands for the other members have yet to be determined. The extracellular portions of the different LIR proteins contain different numbers of Ig-like domains for example, four in the case of LILRB1, and LILRB2, and two in the case of LILRB4 (also known as LIR-5). The activating natural cytotoxicity receptor NKp46 is expressed in natural killer cells, and is organized as an extracellular portion having two Ig-like extracellular domains, a transmembrane domain, and a small cytoplasmic portion. GPVI, which also contains two Ig-like domains, participates in the processes of collagen-mediated platelet activation and arterial thrombus formation. Fc-alphaRI is expressed on monocytes, eosinophils, neutrophils, and macrophages; it mediates IgA-induced immune effector responses such as phagocytosis, antibody-dependent cell-mediated cytotoxicity and respiratory burst. Killer cell immunoglobulin-like receptors (KIRs; also known as CD158 for human KIR) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. KIRs are a family of highly polymorphic activating and inhibitory receptors that serve as key regulators of human NK cell function. The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The major ligands for KIR are MHC class I (HLA-A, -B or -C) molecules.


Pssm-ID: 409518 [Multi-domain]  Cd Length: 90  Bit Score: 41.60  E-value: 5.60e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 6753832   47 ENVTLWCEGPhlPGDSSTQWFINGTAVQISTP---------SYSIPEASFQDSGEYRCQIGS----SMPSDPVQL 108
Cdd:cd16843  16 ENVTIRCQGP--PEAVLFQLYKEGNSLSQGTVrekepqnkaEFYIPHMDRNHAGRYRCRYRSgtlwSEPSDPLEL 88
Ig2_FcgammaR_like cd05753
Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains; ...
 35-110 1.88e-04

Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains; The members here are composed of the second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs). Interactions between IgG and FcgammaR are important to the initiation of cellular and humoral response. IgG binding to FcgammaR leads to a cascade of signals and ultimately to functions such as antibody-dependent-cellular-cytotoxicity (ADCC), endocytosis, phagocytosis, release of inflammatory mediators, etc. FcgammaR has two Ig-like domains. This group also contains FcepsilonRI which binds IgE with high affinity.


Pssm-ID: 409411  Cd Length: 83  Bit Score: 39.98  E-value: 1.88e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753832   35 TLQ-PPWVsIFQKENVTLWCEGPHLPGDSSTQWFINGTAVQIS--TPSYSIPEASFQDSGEYRC--QIGS-SMPSDPVQL 108
Cdd:cd05753   3 LLQaPSAV-VFEGEPLTLRCHGWKDKKVHKVTYYKDGKALKFSyeNSNFSIPQATLSDSGSYHCsgTVRIkRRSSESVNI 81


                ..
gi 6753832  109 QI 110
Cdd:cd05753  82 TV 83
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 213-271 1.23e-03

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 37.48  E-value: 1.23e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 6753832     213 EGSLVTLNCETN------LLLQRPGLQLHFsfYVGSKILEYRNTSSEYHIARAEREDAGFYWCEV 271
Cdd:smart00410   8 EGESVTLSCEASgspppeVTWYKQGGKLLA--ESGRFSVSRSGSTSTLTISNVTPEDSGTYTCAA 70
IgC2_D1_LILR_KIR_like cd05751
First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILRs), Natural ...
 43-108 1.25e-03

First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILRs), Natural killer inhibitory receptors (KIRs) and similar domains; member of Immunoglobulin Constant-2 set of IgSF domains; The members here are composed of the first immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILRs) and Natural killer inhibitory receptors (KIRs, also known as also known as cluster of differentiation (CD) 158), and similar proteins. This group includes LILRB1 (also known as LIR-1), LILRA5 (also known as LIR9), an activating natural cytotoxicity receptor NKp46, the immune-type receptor glycoprotein VI (GPVI), and the IgA-specific receptor Fc-alphaRI (also known as cluster of differentiation (CD) 89). LILRs are a family of immunoreceptors expressed on expressed on T and B cells, on monocytes, dendritic cells, and subgroups of natural killer (NK) cells. The human LILR family contains nine proteins (LILRA1-3, and 5, and LILRB1-5). From functional assays, and as the cytoplasmic domains of various LILRs, for example LILRB1, LILRB2 (also known as LIR-2), and LILRB3 (also known as LIR-3) contain immunoreceptor tyrosine-based inhibitory motifs (ITIMs), it is thought that LIR proteins are inhibitory receptors. Of the eight LIR family proteins, only LILRB1, and LILRB2, show detectable binding to class I MHC molecules; ligands for the other members have yet to be determined. The extracellular portions of the different LIR proteins contain different numbers of Ig-like domains for example, four in the case of LILRB1, and LILRB2, and two in the case of LILRB4 (also known as LIR-5). The activating natural cytotoxicity receptor NKp46 is expressed in natural killer cells, and is organized as an extracellular portion having two Ig-like extracellular domains, a transmembrane domain, and a small cytoplasmic portion. GPVI, which also contains two Ig-like domains, participates in the processes of collagen-mediated platelet activation and arterial thrombus formation. Fc-alphaRI is expressed on monocytes, eosinophils, neutrophils, and macrophages; it mediates IgA-induced immune effector responses such as phagocytosis, antibody-dependent cell-mediated cytotoxicity and respiratory burst. Killer cell immunoglobulin-like receptors (KIRs; also known as CD158 for human KIR) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. KIRs are a family of highly polymorphic activating and inhibitory receptors that serve as key regulators of human NK cell function. The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The major ligands for KIR are MHC class I (HLA-A, -B or -C) molecules.


Pssm-ID: 409409  Cd Length: 88  Bit Score: 37.81  E-value: 1.25e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 6753832   43 IFQKENVTLWCEGPhlPGDSSTQWFINGTAVQ-------ISTPSYSIPEASFQDSGEYRCQIGS----SMPSDPVQL 108
Cdd:cd05751  12 IPLEKSVTIRCQGT--PEAFLYQLEKEGNSTEtvipkkpQKKAEFIIPHMNSRTAGRYRCRYRKgagwSEPSDLLEL 86
IgI_hCEACAM_2_4_6_like cd05740
Immunoglobulin (Ig)-like domain of human carcinoembryonic antigen (CEA) related cell adhesion ...
 46-110 1.35e-03

Immunoglobulin (Ig)-like domain of human carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM) domains 2, 4, and 6, and similar domains; The members here are composed of the second, fourth, and sixth immunoglobulin (Ig)-like domains in human carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM) protein subfamily. The CEA family is a group of anchored or secreted glycoproteins expressed by epithelial cells, leukocytes, endothelial cells, and placenta. The CEA family is divided into the CEACAM and pregnancy-specific glycoprotein (PSG) subfamilies. This group represents the CEACAM subfamily. CEACAM1 has many important cellular functions; it is a cell adhesion molecule and a signaling molecule that regulates the growth of tumor cells, an angiogenic factor, and a receptor for bacterial and viral pathogens, including mouse hepatitis virus (MHV). In mice, four isoforms of CEACAM1 generated by alternative splicing have either two [D1, D4] or four [D1-D4] Ig-like domains on the cell surface.


Pssm-ID: 409402 [Multi-domain]  Cd Length: 89  Bit Score: 37.76  E-value: 1.35e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 6753832   46 KENVTLWCEGPHLpgDSSTQWFINGTAVQIS---TPS-----YSIPEASFQDSGEYRCQIG---SSMPSDPVQLQI 110
Cdd:cd05740  15 KDAVTLTCEPETQ--NTSYLWWFNGQSLPVTprlTLSngnrtLTLLNVTREDAGAYQCEISnpvSANRSDPVTLDV 88
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 125-194 2.10e-03

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 37.10  E-value: 2.10e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753832     125 TEGEPLALRCHGWKNKlVYNVVFYRNGKS-------FQFSSDSEVAIL---KTNLSHSGIYHCSGTGRHRYTSAGVSITV 194
Cdd:smart00410   7 KEGESVTLSCEASGSP-PPEVTWYKQGGKllaesgrFSVSRSGSTSTLtisNVTPEDSGTYTCAATNSSGSASSGTTLTV 85
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 38-110 3.27e-03

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 36.33  E-value: 3.27e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753832      38 PPWVSIFQKENVTLWCEGPHLPgDSSTQWFINGTAVQISTPSYS-----------IPEASFQDSGEYRCQIGSSMPSD-- 104
Cdd:smart00410   1 PPSVTVKEGESVTLSCEASGSP-PPEVTWYKQGGKLLAESGRFSvsrsgststltISNVTPEDSGTYTCAATNSSGSAss 79


                   ....*.
gi 6753832     105 PVQLQI 110
Cdd:smart00410  80 GTTLTV 85
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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