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Conserved domains on  [gi|160298126|ref|NP_034410|]
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GDNF family receptor alpha-3 preproprotein [Mus musculus]

Protein Classification

GDNF family receptor alpha( domain architecture ID 10658249)

glial cell line-derived neurotrophic factor (GDNF) family receptor alpha is a glycosylphosphatidylinositol-linked cell surface receptor for GDNF, the glial cell line-derived neurotrophic factor

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GDNF pfam02351
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 245-337 7.57e-21

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


:

Pssm-ID: 460537  Cd Length: 87  Bit Score: 86.05  E-value: 7.57e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160298126  245 CLDLRSFCRADPLCRSRLMDFQTHCHPMDILGTCATEQSRCLRAYlgligtAMTPNFISKVNTTVALSCTCRGSGNLQDE 324
Cdd:pfam02351   1 CLEAAKACRADEVCRSRLADFQSNCQPSPESCSGCPNPARCLRAY------RMTPNYVDNLGTSLLLWCTCKGSGNQDEE 74

                          90
                  ....*....|...
gi 160298126  325 CEQLERSFSQNPC 337
Cdd:pfam02351  75 CEEFRRNFTVNSC 87
GDNF pfam02351
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 159-236 6.34e-09

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


:

Pssm-ID: 460537  Cd Length: 87  Bit Score: 52.53  E-value: 6.34e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160298126  159 CLKFAMLCTLHDKCDRLRKAYGEAC--SGIRCQRHL----CLAQLRSFFEKAAESHAQGLLLCPCA---PEDAGCGERRR 229
Cdd:pfam02351   1 CLEAAKACRADEVCRSRLADFQSNCqpSPESCSGCPnparCLRAYRMTPNYVDNLGTSLLLWCTCKgsgNQDEECEEFRR 80


                  ....*..
gi 160298126  230 NTIAPSC 236
Cdd:pfam02351  81 NFTVNSC 87
GDNF smart00907
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 41-118 1.01e-06

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons.. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


:

Pssm-ID: 197975  Cd Length: 86  Bit Score: 46.48  E-value: 1.01e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160298126    41 CTQARKKCEANPACK-AAYQHLGSCTSSLSRPLPLEesaMSADCLEAAEQLRNSSLID--------CRCHRrmKHQATCL 111
Cdd:smart00907   1 CLEALKACELDPVCRsRLADYLSACSPSPSSSCPGE---NSEACLRAYCGLALRPFYDdnssvllfCTCAG--NRDEECL 75


                   ....*..
gi 160298126   112 DIYWTVH 118
Cdd:smart00907  76 EFRRLFH 82
 
Name Accession Description Interval E-value
GDNF pfam02351
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 245-337 7.57e-21

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


Pssm-ID: 460537  Cd Length: 87  Bit Score: 86.05  E-value: 7.57e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160298126  245 CLDLRSFCRADPLCRSRLMDFQTHCHPMDILGTCATEQSRCLRAYlgligtAMTPNFISKVNTTVALSCTCRGSGNLQDE 324
Cdd:pfam02351   1 CLEAAKACRADEVCRSRLADFQSNCQPSPESCSGCPNPARCLRAY------RMTPNYVDNLGTSLLLWCTCKGSGNQDEE 74

                          90
                  ....*....|...
gi 160298126  325 CEQLERSFSQNPC 337
Cdd:pfam02351  75 CEEFRRNFTVNSC 87
GDNF smart00907
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 245-337 8.08e-16

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons.. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


Pssm-ID: 197975  Cd Length: 86  Bit Score: 72.29  E-value: 8.08e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160298126   245 CLDLRSFCRADPLCRSRLMDFQTHCHPMDILGTCATEQSRCLRAYlglIGTAMTPNFISkvNTTVALSCTCRgsGNLQDE 324
Cdd:smart00907   1 CLEALKACELDPVCRSRLADYLSACSPSPSSSCPGENSEACLRAY---CGLALRPFYDD--NSSVLLFCTCA--GNRDEE 73

                           90
                   ....*....|...
gi 160298126   325 CEQLERSFSQNPC 337
Cdd:smart00907  74 CLEFRRLFHSNPC 86
GDNF pfam02351
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 159-236 6.34e-09

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


Pssm-ID: 460537  Cd Length: 87  Bit Score: 52.53  E-value: 6.34e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160298126  159 CLKFAMLCTLHDKCDRLRKAYGEAC--SGIRCQRHL----CLAQLRSFFEKAAESHAQGLLLCPCA---PEDAGCGERRR 229
Cdd:pfam02351   1 CLEAAKACRADEVCRSRLADFQSNCqpSPESCSGCPnparCLRAYRMTPNYVDNLGTSLLLWCTCKgsgNQDEECEEFRR 80


                  ....*..
gi 160298126  230 NTIAPSC 236
Cdd:pfam02351  81 NFTVNSC 87
GDNF smart00907
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 159-236 5.32e-08

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons.. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


Pssm-ID: 197975  Cd Length: 86  Bit Score: 49.95  E-value: 5.32e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160298126   159 CLKFAMLCTLHDKCDRLRKAYGEACSG-----------IRCQRHLCLAQLRSFFekaaESHAQGLLLCPCA-PEDAGCGE 226
Cdd:smart00907   1 CLEALKACELDPVCRSRLADYLSACSPspssscpgensEACLRAYCGLALRPFY----DDNSSVLLFCTCAgNRDEECLE 76

                           90
                   ....*....|
gi 160298126   227 RRRNTIAPSC 236
Cdd:smart00907  77 FRRLFHSNPC 86
GDNF smart00907
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 41-118 1.01e-06

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons.. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


Pssm-ID: 197975  Cd Length: 86  Bit Score: 46.48  E-value: 1.01e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160298126    41 CTQARKKCEANPACK-AAYQHLGSCTSSLSRPLPLEesaMSADCLEAAEQLRNSSLID--------CRCHRrmKHQATCL 111
Cdd:smart00907   1 CLEALKACELDPVCRsRLADYLSACSPSPSSSCPGE---NSEACLRAYCGLALRPFYDdnssvllfCTCAG--NRDEECL 75


                   ....*..
gi 160298126   112 DIYWTVH 118
Cdd:smart00907  76 EFRRLFH 82
 
Name Accession Description Interval E-value
GDNF pfam02351
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 245-337 7.57e-21

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


Pssm-ID: 460537  Cd Length: 87  Bit Score: 86.05  E-value: 7.57e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160298126  245 CLDLRSFCRADPLCRSRLMDFQTHCHPMDILGTCATEQSRCLRAYlgligtAMTPNFISKVNTTVALSCTCRGSGNLQDE 324
Cdd:pfam02351   1 CLEAAKACRADEVCRSRLADFQSNCQPSPESCSGCPNPARCLRAY------RMTPNYVDNLGTSLLLWCTCKGSGNQDEE 74

                          90
                  ....*....|...
gi 160298126  325 CEQLERSFSQNPC 337
Cdd:pfam02351  75 CEEFRRNFTVNSC 87
GDNF smart00907
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 245-337 8.08e-16

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons.. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


Pssm-ID: 197975  Cd Length: 86  Bit Score: 72.29  E-value: 8.08e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160298126   245 CLDLRSFCRADPLCRSRLMDFQTHCHPMDILGTCATEQSRCLRAYlglIGTAMTPNFISkvNTTVALSCTCRgsGNLQDE 324
Cdd:smart00907   1 CLEALKACELDPVCRSRLADYLSACSPSPSSSCPGENSEACLRAY---CGLALRPFYDD--NSSVLLFCTCA--GNRDEE 73

                           90
                   ....*....|...
gi 160298126   325 CEQLERSFSQNPC 337
Cdd:smart00907  74 CLEFRRLFHSNPC 86
GDNF pfam02351
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 159-236 6.34e-09

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


Pssm-ID: 460537  Cd Length: 87  Bit Score: 52.53  E-value: 6.34e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160298126  159 CLKFAMLCTLHDKCDRLRKAYGEAC--SGIRCQRHL----CLAQLRSFFEKAAESHAQGLLLCPCA---PEDAGCGERRR 229
Cdd:pfam02351   1 CLEAAKACRADEVCRSRLADFQSNCqpSPESCSGCPnparCLRAYRMTPNYVDNLGTSLLLWCTCKgsgNQDEECEEFRR 80


                  ....*..
gi 160298126  230 NTIAPSC 236
Cdd:pfam02351  81 NFTVNSC 87
GDNF smart00907
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 159-236 5.32e-08

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons.. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


Pssm-ID: 197975  Cd Length: 86  Bit Score: 49.95  E-value: 5.32e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160298126   159 CLKFAMLCTLHDKCDRLRKAYGEACSG-----------IRCQRHLCLAQLRSFFekaaESHAQGLLLCPCA-PEDAGCGE 226
Cdd:smart00907   1 CLEALKACELDPVCRSRLADYLSACSPspssscpgensEACLRAYCGLALRPFY----DDNSSVLLFCTCAgNRDEECLE 76

                           90
                   ....*....|
gi 160298126   227 RRRNTIAPSC 236
Cdd:smart00907  77 FRRLFHSNPC 86
GDNF smart00907
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 41-118 1.01e-06

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons.. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


Pssm-ID: 197975  Cd Length: 86  Bit Score: 46.48  E-value: 1.01e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160298126    41 CTQARKKCEANPACK-AAYQHLGSCTSSLSRPLPLEesaMSADCLEAAEQLRNSSLID--------CRCHRrmKHQATCL 111
Cdd:smart00907   1 CLEALKACELDPVCRsRLADYLSACSPSPSSSCPGE---NSEACLRAYCGLALRPFYDdnssvllfCTCAG--NRDEECL 75


                   ....*..
gi 160298126   112 DIYWTVH 118
Cdd:smart00907  76 EFRRLFH 82
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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