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Conserved domains on  [gi|93004088|ref|NP_055215|]
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ly6/PLAUR domain-containing protein 3 precursor [Homo sapiens]

Protein Classification

ly6/PLAUR domain-containing protein 3( domain architecture ID 10061497)

ly6/PLAUR domain-containing protein 3 (LYPD3/C4.4A) may be involved in urothelial cell-matrix interactions, as well as in tumor progression; contains two LU (Ly-6 antigen/uPA receptor-like) domains

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TFP_LU_ECD_LYPD3_rpt2 cd23563
second extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 3 (LYPD3) and ...
 135-226 2.62e-41

second extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 3 (LYPD3) and similar proteins; LYPD3 (also called GPI-anchored metastasis-associated protein C4.4A homolog, or matrigel-induced gene C4 protein (MIG-C4)) supports cell migration. It may be involved in urothelial cell-matrix interactions as well as in tumor progression. LYPD3 contains two extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the second ECD.


:

Pssm-ID: 467093  Cd Length: 88  Bit Score: 139.51  E-value: 2.62e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004088 135 PNGVECYSCVGLSREACQGTSPPVVSCYNAsdhvYKGCFDGNVTLTAANVTVSLPVRGCVQDEFCTRDGVTGPGFTLSGS 214
Cdd:cd23563   1 PNGVECYSCVGNSRGACSPSNAPVVRCYGA----YSGCFDGNVTLTIGNVTLSLPVKGCVQDGDCTRESKGGASVTLKGS 76

                        90
                ....*....|..
gi 93004088 215 CCQGSRCNSDLR 226
Cdd:cd23563  77 CCSGNLCNSDLS 88
TFP_LU_ECD_LYPD3_rpt1 cd23562
first extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 3 (LYPD3) and ...
 31-117 3.61e-38

first extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 3 (LYPD3) and similar proteins; LYPD3 (also called GPI-anchored metastasis-associated protein C4.4A homolog, or matrigel-induced gene C4 protein (MIG-C4)) supports cell migration. It may be involved in urothelial cell-matrix interactions as well as in tumor progression. LYPD3 contains two extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the first ECD.


:

Pssm-ID: 467092  Cd Length: 87  Bit Score: 131.32  E-value: 3.61e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004088  31 LECYSCVQKADDGCSPNKMKTVKCAPGVDVCTEAVGAVETIHGQFSLAVRGCGSGLPGKNDRGLDLHGLLAFIQLQQCAQ 110
Cdd:cd23562   1 LECYSCVEEGDGGCSPAKMTTVSCAPPMNVCTEYVAAVKTSHGTLTLRKKGCGSGLPGKLDRGLTLHGLYAFIQLRACNT 80


                ....*..
gi 93004088 111 DRCNAKL 117
Cdd:cd23562  81 SLCNNEL 87
 
Name Accession Description Interval E-value
TFP_LU_ECD_LYPD3_rpt2 cd23563
second extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 3 (LYPD3) and ...
 135-226 2.62e-41

second extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 3 (LYPD3) and similar proteins; LYPD3 (also called GPI-anchored metastasis-associated protein C4.4A homolog, or matrigel-induced gene C4 protein (MIG-C4)) supports cell migration. It may be involved in urothelial cell-matrix interactions as well as in tumor progression. LYPD3 contains two extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the second ECD.


Pssm-ID: 467093  Cd Length: 88  Bit Score: 139.51  E-value: 2.62e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004088 135 PNGVECYSCVGLSREACQGTSPPVVSCYNAsdhvYKGCFDGNVTLTAANVTVSLPVRGCVQDEFCTRDGVTGPGFTLSGS 214
Cdd:cd23563   1 PNGVECYSCVGNSRGACSPSNAPVVRCYGA----YSGCFDGNVTLTIGNVTLSLPVKGCVQDGDCTRESKGGASVTLKGS 76

                        90
                ....*....|..
gi 93004088 215 CCQGSRCNSDLR 226
Cdd:cd23563  77 CCSGNLCNSDLS 88
TFP_LU_ECD_LYPD3_rpt1 cd23562
first extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 3 (LYPD3) and ...
 31-117 3.61e-38

first extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 3 (LYPD3) and similar proteins; LYPD3 (also called GPI-anchored metastasis-associated protein C4.4A homolog, or matrigel-induced gene C4 protein (MIG-C4)) supports cell migration. It may be involved in urothelial cell-matrix interactions as well as in tumor progression. LYPD3 contains two extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the first ECD.


Pssm-ID: 467092  Cd Length: 87  Bit Score: 131.32  E-value: 3.61e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004088  31 LECYSCVQKADDGCSPNKMKTVKCAPGVDVCTEAVGAVETIHGQFSLAVRGCGSGLPGKNDRGLDLHGLLAFIQLQQCAQ 110
Cdd:cd23562   1 LECYSCVEEGDGGCSPAKMTTVSCAPPMNVCTEYVAAVKTSHGTLTLRKKGCGSGLPGKLDRGLTLHGLYAFIQLRACNT 80


                ....*..
gi 93004088 111 DRCNAKL 117
Cdd:cd23562  81 SLCNNEL 87
UPAR_LY6 pfam00021
u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087.
 140-222 4.59e-14

u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087.


Pssm-ID: 394978  Cd Length: 77  Bit Score: 66.41  E-value: 4.59e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004088   140 CYSCVGLSREACqgtsPPVVSCYNASDHvykgCFDGNVTLTAANVTVSLPVRGCVQdEFCTR---DGVTGPGFTLSGSCC 216
Cdd:pfam00021   1 CYSCLGVSNEDC----LSEVTCPLSDGQ----CVTTTLELPEGNLRGTVVSKGCAR-SSCPRllsDFINGGIISVSESCC 71


                  ....*.
gi 93004088   217 QGSRCN 222
Cdd:pfam00021  72 QSDLCN 77
LU smart00134
Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type ...
 31-118 8.36e-11

Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type plasminogen activator receptor; occurs singly in other GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2). Topology of these domains is similar to that of snake venom neurotoxins.


Pssm-ID: 214530  Cd Length: 85  Bit Score: 57.54  E-value: 8.36e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004088     31 LECYSCVQKADDGCSPnkmkTVKCAPGVDVCTEAVGAVETIHGQfSLAVRGCG--SGLPGKNdrGLDLHGLLAFIQLQQC 108
Cdd:smart00134   1 LQCYSCTGNPDSSCSS----EEECRSPDDVCLTVVAEVISDSRG-SVVYKGCAtsPICPGSH--GYEINLTIAFLKVSCC 73

                           90
                   ....*....|
gi 93004088    109 AQDRCNAKLN 118
Cdd:smart00134  74 QTDLCNAAGP 83
 
Name Accession Description Interval E-value
TFP_LU_ECD_LYPD3_rpt2 cd23563
second extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 3 (LYPD3) and ...
 135-226 2.62e-41

second extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 3 (LYPD3) and similar proteins; LYPD3 (also called GPI-anchored metastasis-associated protein C4.4A homolog, or matrigel-induced gene C4 protein (MIG-C4)) supports cell migration. It may be involved in urothelial cell-matrix interactions as well as in tumor progression. LYPD3 contains two extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the second ECD.


Pssm-ID: 467093  Cd Length: 88  Bit Score: 139.51  E-value: 2.62e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004088 135 PNGVECYSCVGLSREACQGTSPPVVSCYNAsdhvYKGCFDGNVTLTAANVTVSLPVRGCVQDEFCTRDGVTGPGFTLSGS 214
Cdd:cd23563   1 PNGVECYSCVGNSRGACSPSNAPVVRCYGA----YSGCFDGNVTLTIGNVTLSLPVKGCVQDGDCTRESKGGASVTLKGS 76

                        90
                ....*....|..
gi 93004088 215 CCQGSRCNSDLR 226
Cdd:cd23563  77 CCSGNLCNSDLS 88
TFP_LU_ECD_LYPD3_rpt1 cd23562
first extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 3 (LYPD3) and ...
 31-117 3.61e-38

first extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 3 (LYPD3) and similar proteins; LYPD3 (also called GPI-anchored metastasis-associated protein C4.4A homolog, or matrigel-induced gene C4 protein (MIG-C4)) supports cell migration. It may be involved in urothelial cell-matrix interactions as well as in tumor progression. LYPD3 contains two extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the first ECD.


Pssm-ID: 467092  Cd Length: 87  Bit Score: 131.32  E-value: 3.61e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004088  31 LECYSCVQKADDGCSPNKMKTVKCAPGVDVCTEAVGAVETIHGQFSLAVRGCGSGLPGKNDRGLDLHGLLAFIQLQQCAQ 110
Cdd:cd23562   1 LECYSCVEEGDGGCSPAKMTTVSCAPPMNVCTEYVAAVKTSHGTLTLRKKGCGSGLPGKLDRGLTLHGLYAFIQLRACNT 80


                ....*..
gi 93004088 111 DRCNAKL 117
Cdd:cd23562  81 SLCNNEL 87
UPAR_LY6 pfam00021
u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087.
 140-222 4.59e-14

u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087.


Pssm-ID: 394978  Cd Length: 77  Bit Score: 66.41  E-value: 4.59e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004088   140 CYSCVGLSREACqgtsPPVVSCYNASDHvykgCFDGNVTLTAANVTVSLPVRGCVQdEFCTR---DGVTGPGFTLSGSCC 216
Cdd:pfam00021   1 CYSCLGVSNEDC----LSEVTCPLSDGQ----CVTTTLELPEGNLRGTVVSKGCAR-SSCPRllsDFINGGIISVSESCC 71


                  ....*.
gi 93004088   217 QGSRCN 222
Cdd:pfam00021  72 QSDLCN 77
TFP_LU_ECD_LYPD5_rpt2 cd23566
second extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 5 (LYPD5) and ...
 134-224 2.72e-11

second extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 5 (LYPD5) and similar proteins; LYPD5 (also called Haldisin (human antigen with LU-domains expressed in skin)) is a novel differentiation marker of stratum granulosum in squamous epithelia. LYPD5 contains two extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the second ECD.


Pssm-ID: 467096  Cd Length: 96  Bit Score: 59.34  E-value: 2.72e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004088 134 PPNGVECYSCVGLSREACQGTSPPVVSCYNASDHvykgCFDGNVTLTAANVTVSLP--VRGCvQDEFCTRDGVTGPGF-- 209
Cdd:cd23566   5 TPNGMECYACLSFSPDDCSPENAEKVKCHGDMTR----CYEGNGTVTIGNDNFSVPiyIKTC-QAPSCTTPGSTSPWTai 79

                        90
                ....*....|....*.
gi 93004088 210 -TLSGSCCQGSRCNSD 224
Cdd:cd23566  80 iSQQGSCCSGSLCNGP 95
LU smart00134
Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type ...
 31-118 8.36e-11

Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type plasminogen activator receptor; occurs singly in other GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2). Topology of these domains is similar to that of snake venom neurotoxins.


Pssm-ID: 214530  Cd Length: 85  Bit Score: 57.54  E-value: 8.36e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004088     31 LECYSCVQKADDGCSPnkmkTVKCAPGVDVCTEAVGAVETIHGQfSLAVRGCG--SGLPGKNdrGLDLHGLLAFIQLQQC 108
Cdd:smart00134   1 LQCYSCTGNPDSSCSS----EEECRSPDDVCLTVVAEVISDSRG-SVVYKGCAtsPICPGSH--GYEINLTIAFLKVSCC 73

                           90
                   ....*....|
gi 93004088    109 AQDRCNAKLN 118
Cdd:smart00134  74 QTDLCNAAGP 83
TFP_LU_ECD_uPAR_rpt3 cd23558
third extracellular domain (ECD) found in urokinase plasminogen activator surface receptor ...
 131-223 6.79e-07

third extracellular domain (ECD) found in urokinase plasminogen activator surface receptor (uPAR) and similar proteins; uPAR (also called U-PAR, or monocyte activation antigen Mo3, or CD87) acts as a receptor for urokinase plasminogen activator. It plays a role in localizing and promoting plasmin formation. It mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form. uPAR contains three extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the third ECD.


Pssm-ID: 467088  Cd Length: 93  Bit Score: 47.00  E-value: 6.79e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004088 131 SAYPPNGVECYSCVGLSREACQGTSPPVVSCYNASDHvykgCFDGNVTLTAANVTVSLPVRGCVQDEFCtrdgvTGPGFT 210
Cdd:cd23558   1 PDLPPNGIQCYSCNGNSTHGCSSEETSKVRCRGPQTQ----CLEATGTTAHGGKNQSYMVKGCATPSMC-----QSTALS 71

                        90       100
                ....*....|....*....|
gi 93004088 211 LSG-------SCCQGSRCNS 223
Cdd:cd23558  72 LNQvlnsadvRCCNGSLCNN 91
TFP_LU_ECD_uPAR_rpt3 cd23558
third extracellular domain (ECD) found in urokinase plasminogen activator surface receptor ...
 30-84 3.21e-05

third extracellular domain (ECD) found in urokinase plasminogen activator surface receptor (uPAR) and similar proteins; uPAR (also called U-PAR, or monocyte activation antigen Mo3, or CD87) acts as a receptor for urokinase plasminogen activator. It plays a role in localizing and promoting plasmin formation. It mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form. uPAR contains three extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the third ECD.


Pssm-ID: 467088  Cd Length: 93  Bit Score: 42.00  E-value: 3.21e-05
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*
gi 93004088  30 ALECYSCVQKADDGCSPNKMKTVKCAPGVDVCTEAVGAVETIHGQFSLAVRGCGS 84
Cdd:cd23558   7 GIQCYSCNGNSTHGCSSEETSKVRCRGPQTQCLEATGTTAHGGKNQSYMVKGCAT 61
TFP cd00117
three-fingered protein (TFP) fold found in Ly6/uPAR (LU) and snake toxin superfamily; The LU ...
 31-114 9.94e-05

three-fingered protein (TFP) fold found in Ly6/uPAR (LU) and snake toxin superfamily; The LU (also known as Ly-6 antigen/uPA receptor)-like extracellular domain (ECD) occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. It is a structural domain involved in protein-protein interactions, tolerating an unusual degree of variation and binding with high specificity to a broad spectrum of targets. The snake toxin domain is present in short and long neurotoxins, cytotoxins, and short toxins, and in other miscellaneous venom peptides. The toxin acts by binding to the nicotinic acetylcholine receptors in the postsynaptic membrane of skeletal muscles and preventing the binding of acetylcholine, thereby blocking the excitation of muscles. Both the LU-like ECD and the snake toxin domain belong to three-fingered protein (TFP) fold, which is characterized by containing 70 to 100 amino acids including eight to ten cysteine residues spaced at conserved distances.


Pssm-ID: 467060  Cd Length: 81  Bit Score: 40.55  E-value: 9.94e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004088  31 LECYSCVQKADDGCSPNKMKTVKCAPGVDVCTEAVGaveTIHGQFSLAVRGCGSGLPGKNDRGLDLHGLLAFIQLQQCAQ 110
Cdd:cd00117   1 LKCYQCNSSNDPNCCNSSPTLVTCSSPETFCRKIVG---KVGGGETLVIRGCATECECGCTECCSGTGTSGTTCTSCCDT 77


                ....
gi 93004088 111 DRCN 114
Cdd:cd00117  78 DLCN 81
TFP_LU_ECD_LYPD5_rpt2 cd23566
second extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 5 (LYPD5) and ...
 31-79 8.59e-04

second extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 5 (LYPD5) and similar proteins; LYPD5 (also called Haldisin (human antigen with LU-domains expressed in skin)) is a novel differentiation marker of stratum granulosum in squamous epithelia. LYPD5 contains two extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the second ECD.


Pssm-ID: 467096  Cd Length: 96  Bit Score: 38.16  E-value: 8.59e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*....
gi 93004088  31 LECYSCVQKADDGCSPNKMKTVKCAPGVDVCTEAVGAVETIHGQFSLAV 79
Cdd:cd23566   9 MECYACLSFSPDDCSPENAEKVKCHGDMTRCYEGNGTVTIGNDNFSVPI 57
TFP_LU_ECD_uPAR_rpt1 cd23556
first extracellular domain (ECD) found in urokinase plasminogen activator surface receptor ...
 31-114 9.79e-04

first extracellular domain (ECD) found in urokinase plasminogen activator surface receptor (uPAR) and similar proteins; uPAR (also called U-PAR, or monocyte activation antigen Mo3, or CD87) acts as a receptor for urokinase plasminogen activator. It plays a role in localizing and promoting plasmin formation. It mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form. uPAR contains three extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the first ECD.


Pssm-ID: 467086  Cd Length: 79  Bit Score: 37.44  E-value: 9.79e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004088  31 LECYSCvqKADDGCSpnkmKTVKCAPGVDVCTEAVGAVETIHGQFSLAVRGCGSGLPGKNDRGLDLHGLLAFIQLQQCAQ 110
Cdd:cd23556   1 LRCYSC--KSNGDCR----VEEVCALGQDLCRTTVMTLWEEGEELELVVKGCDVSGKTNASSSYRTGLNINSLQETVCSS 74


                ....
gi 93004088 111 DRCN 114
Cdd:cd23556  75 DLCN 78
TFP cd00117
three-fingered protein (TFP) fold found in Ly6/uPAR (LU) and snake toxin superfamily; The LU ...
 139-222 1.20e-03

three-fingered protein (TFP) fold found in Ly6/uPAR (LU) and snake toxin superfamily; The LU (also known as Ly-6 antigen/uPA receptor)-like extracellular domain (ECD) occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. It is a structural domain involved in protein-protein interactions, tolerating an unusual degree of variation and binding with high specificity to a broad spectrum of targets. The snake toxin domain is present in short and long neurotoxins, cytotoxins, and short toxins, and in other miscellaneous venom peptides. The toxin acts by binding to the nicotinic acetylcholine receptors in the postsynaptic membrane of skeletal muscles and preventing the binding of acetylcholine, thereby blocking the excitation of muscles. Both the LU-like ECD and the snake toxin domain belong to three-fingered protein (TFP) fold, which is characterized by containing 70 to 100 amino acids including eight to ten cysteine residues spaced at conserved distances.


Pssm-ID: 467060  Cd Length: 81  Bit Score: 37.46  E-value: 1.20e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004088 139 ECYSCVGLSREACQGTSPPVVSCYNASDHvykgCFDGNVTLTAANVTVslpVRGCVQDEFCTRDG---VTGPGFTLSGSC 215
Cdd:cd00117   2 KCYQCNSSNDPNCCNSSPTLVTCSSPETF----CRKIVGKVGGGETLV---IRGCATECECGCTEccsGTGTSGTTCTSC 74


                ....*..
gi 93004088 216 CQGSRCN 222
Cdd:cd00117  75 CDTDLCN 81
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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