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Conserved domains on  [gi|38016202|ref|NP_056080|]
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DNA-binding protein SATB2 [Homo sapiens]

Protein Classification

CUT homeobox family transcription factor; homeobox domain-containing protein( domain architecture ID 11243844)

CUT homeobox family transcription factor regulates gene networks by controlling the expression of other transcription factors and plays an important role in cell differentiation and metabolism| homeobox domain-containing protein may be involved in the transcriptional regulation of key eukaryotic developmental processes

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ULD pfam16534
Ubiquitin-like oligomerization domain of SATB; ULD is an N-terminal oligomerization domain of ...
 58-156 2.45e-52

Ubiquitin-like oligomerization domain of SATB; ULD is an N-terminal oligomerization domain of SATB or special AT-rich sequence-binding proteins. SATBs are global chromatin organizers and regulators of gene expression that are essential for T-cell development, breast cancer tumour growth and metastasis. SATBs assemble into a tetramer via the ULD domain, and the tetramerization of SATBs are essential for recognising specific DNA sequences (such as multiple AT-rich DNA fragments). Thus, SATBs may regulate gene expression directly by binding to various promoters and upstream regions and thereby influencing promoter activity.


:

Pssm-ID: 465165  Cd Length: 105  Bit Score: 176.38  E-value: 2.45e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38016202    58 LMIPVFCVVEQLDGSLEYDNRE------EHAEFVLVRKDVLFSQLVETALLALGYSHSSAAQAQGIIKLGRWNPLPLSYV 131
Cdd:pfam16534   1 KSLPVHCVVEQVESLQESNECDertpnvEHDSYVIIPKDTLFSDLVETALLRLGYSHSSAAQAKGSIQIKNWKPLSLESI 80

                          90       100
                  ....*....|....*....|....*
gi 38016202   132 TDAPDATVADMLQDVYHVVTLKIQL 156
Cdd:pfam16534  81 TDDPDATVGDMLGDLTTVATLRIQL 105
CUTL pfam16557
CUT1-like DNA-binding domain of SATB; CUTL is part of the N-terminal region of SATB proteins, ...
 162-233 1.40e-40

CUT1-like DNA-binding domain of SATB; CUTL is part of the N-terminal region of SATB proteins, special AT-rich sequence-binding proteins that are global chromatin organizers and gene expression regulators essential for T-cell development and breast cancer tumour growth and metastasis. CUTL carries a DNA-binding region just as CUT domains do.


:

Pssm-ID: 435427  Cd Length: 72  Bit Score: 142.76  E-value: 1.40e-40
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 38016202   162 LEDLPAEQWNHATVRNALKELLKEMNQSTLAKECPLSQSMISSIVNSTYYANVSATKCQEFGRWYKKYKKIK 233
Cdd:pfam16557   1 PELLPPDKWTDQTVRCAVKELLKEMLQSTLAKLCPLTQSMISSIVNSTYYANVSADKCQEFGRWYKQYKKIK 72
CUT pfam02376
CUT domain; The CUT domain is a DNA-binding motif which can bind independently or in ...
 477-556 6.96e-22

CUT domain; The CUT domain is a DNA-binding motif which can bind independently or in cooperation with the homeodomain, often found downstream of the CUT domain. Multiple copies of the CUT domain can exist in one protein.


:

Pssm-ID: 460543  Cd Length: 78  Bit Score: 89.96  E-value: 6.96e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38016202   477 DGANINiTAAIYDEIQQEMKRAKVSQALFAKVAANKSQGWLCELLRwkeNPSPenrtlWENLCT-------IRRFLNLPQ 549
Cdd:pfam02376   1 DSEELD-TKDIADRIKEELKRHKISQAVFAEKVLNRSQGTLSDLLR---KPKP-----WEKLKSggrtfirMYNWLSLPE 71


                  ....*..
gi 38016202   550 HERDVIY 556
Cdd:pfam02376  72 DERMEIL 78
CUT pfam02376
CUT domain; The CUT domain is a DNA-binding motif which can bind independently or in ...
 355-433 3.02e-19

CUT domain; The CUT domain is a DNA-binding motif which can bind independently or in cooperation with the homeodomain, often found downstream of the CUT domain. Multiple copies of the CUT domain can exist in one protein.


:

Pssm-ID: 460543  Cd Length: 78  Bit Score: 82.64  E-value: 3.02e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38016202   355 NSSVEVSPDIYQQVRDELKRASVSQAVFARVAFNRTQGLLSEILRKeedPRTASQSLLV--NLRAMQNFLNLPEVERDRI 432
Cdd:pfam02376   1 DSEELDTKDIADRIKEELKRHKISQAVFAEKVLNRSQGTLSDLLRK---PKPWEKLKSGgrTFIRMYNWLSLPEDERMEI 77


                  .
gi 38016202   433 Y 433
Cdd:pfam02376  78 L 78
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 614-671 1.11e-07

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


:

Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 48.79  E-value: 1.11e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 38016202    614 KPRSRTKISLEALGILQSFIHDvGLYPDQEAIHTLSAQLDLPKHTIIKFFQNQRYHVK 671
Cdd:smart00389   1 KRRKRTSFTPEQLEELEKEFQK-NPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
 
Name Accession Description Interval E-value
ULD pfam16534
Ubiquitin-like oligomerization domain of SATB; ULD is an N-terminal oligomerization domain of ...
 58-156 2.45e-52

Ubiquitin-like oligomerization domain of SATB; ULD is an N-terminal oligomerization domain of SATB or special AT-rich sequence-binding proteins. SATBs are global chromatin organizers and regulators of gene expression that are essential for T-cell development, breast cancer tumour growth and metastasis. SATBs assemble into a tetramer via the ULD domain, and the tetramerization of SATBs are essential for recognising specific DNA sequences (such as multiple AT-rich DNA fragments). Thus, SATBs may regulate gene expression directly by binding to various promoters and upstream regions and thereby influencing promoter activity.


Pssm-ID: 465165  Cd Length: 105  Bit Score: 176.38  E-value: 2.45e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38016202    58 LMIPVFCVVEQLDGSLEYDNRE------EHAEFVLVRKDVLFSQLVETALLALGYSHSSAAQAQGIIKLGRWNPLPLSYV 131
Cdd:pfam16534   1 KSLPVHCVVEQVESLQESNECDertpnvEHDSYVIIPKDTLFSDLVETALLRLGYSHSSAAQAKGSIQIKNWKPLSLESI 80

                          90       100
                  ....*....|....*....|....*
gi 38016202   132 TDAPDATVADMLQDVYHVVTLKIQL 156
Cdd:pfam16534  81 TDDPDATVGDMLGDLTTVATLRIQL 105
SATB1_N cd11585
N-terminal domain of SATB1 and similar proteins; SATB1, the special AT-rich sequence-binding ...
 60-155 1.91e-50

N-terminal domain of SATB1 and similar proteins; SATB1, the special AT-rich sequence-binding protein 1, is involved in organizing chromosomal loci into distinct loops, creating a "loopscape" that has a direct bearing on gene expression. This N-terminal domain, which may be involved in various interactions with chromatin proteins, resembles a ubiquitin domain and has been shown to form tetramers, a function critical to SATB1-DNA interactions. The related Drosophila homeobox gene defective proventriculus (dve) plays a key role in the functional specification during endoderm development.


Pssm-ID: 211426  Cd Length: 100  Bit Score: 170.97  E-value: 1.91e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38016202  60 IPVFCVVEQLDGSLE----YDNREEHAEFVLVRKDVLFSQLVETALLALGYSHSSAAQAQGIIKLGRWNPLPLSYVTDAP 135
Cdd:cd11585   1 LPVHCVVETVDSLHEsvwrRRPRVETDSYVIIPKDTLFNQLVETALLRLGYSHSSAASAKGLIQIKNWKPLPFDQITDNP 80

                        90       100
                ....*....|....*....|
gi 38016202 136 DATVADMLQDVYHVVTLKIQ 155
Cdd:cd11585  81 DATVGDMLGELTHVATLRIQ 100
CUTL pfam16557
CUT1-like DNA-binding domain of SATB; CUTL is part of the N-terminal region of SATB proteins, ...
 162-233 1.40e-40

CUT1-like DNA-binding domain of SATB; CUTL is part of the N-terminal region of SATB proteins, special AT-rich sequence-binding proteins that are global chromatin organizers and gene expression regulators essential for T-cell development and breast cancer tumour growth and metastasis. CUTL carries a DNA-binding region just as CUT domains do.


Pssm-ID: 435427  Cd Length: 72  Bit Score: 142.76  E-value: 1.40e-40
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 38016202   162 LEDLPAEQWNHATVRNALKELLKEMNQSTLAKECPLSQSMISSIVNSTYYANVSATKCQEFGRWYKKYKKIK 233
Cdd:pfam16557   1 PELLPPDKWTDQTVRCAVKELLKEMLQSTLAKLCPLTQSMISSIVNSTYYANVSADKCQEFGRWYKQYKKIK 72
CUT pfam02376
CUT domain; The CUT domain is a DNA-binding motif which can bind independently or in ...
 477-556 6.96e-22

CUT domain; The CUT domain is a DNA-binding motif which can bind independently or in cooperation with the homeodomain, often found downstream of the CUT domain. Multiple copies of the CUT domain can exist in one protein.


Pssm-ID: 460543  Cd Length: 78  Bit Score: 89.96  E-value: 6.96e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38016202   477 DGANINiTAAIYDEIQQEMKRAKVSQALFAKVAANKSQGWLCELLRwkeNPSPenrtlWENLCT-------IRRFLNLPQ 549
Cdd:pfam02376   1 DSEELD-TKDIADRIKEELKRHKISQAVFAEKVLNRSQGTLSDLLR---KPKP-----WEKLKSggrtfirMYNWLSLPE 71


                  ....*..
gi 38016202   550 HERDVIY 556
Cdd:pfam02376  72 DERMEIL 78
CUT pfam02376
CUT domain; The CUT domain is a DNA-binding motif which can bind independently or in ...
 355-433 3.02e-19

CUT domain; The CUT domain is a DNA-binding motif which can bind independently or in cooperation with the homeodomain, often found downstream of the CUT domain. Multiple copies of the CUT domain can exist in one protein.


Pssm-ID: 460543  Cd Length: 78  Bit Score: 82.64  E-value: 3.02e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38016202   355 NSSVEVSPDIYQQVRDELKRASVSQAVFARVAFNRTQGLLSEILRKeedPRTASQSLLV--NLRAMQNFLNLPEVERDRI 432
Cdd:pfam02376   1 DSEELDTKDIADRIKEELKRHKISQAVFAEKVLNRSQGTLSDLLRK---PKPWEKLKSGgrTFIRMYNWLSLPEDERMEI 77


                  .
gi 38016202   433 Y 433
Cdd:pfam02376  78 L 78
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 614-671 1.11e-07

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 48.79  E-value: 1.11e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 38016202    614 KPRSRTKISLEALGILQSFIHDvGLYPDQEAIHTLSAQLDLPKHTIIKFFQNQRYHVK 671
Cdd:smart00389   1 KRRKRTSFTPEQLEELEKEFQK-NPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 615-673 7.65e-06

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 43.77  E-value: 7.65e-06
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 38016202 615 PRSRTKISLEALGILQSFIHDVGlYPDQEAIHTLSAQLDLPKHTIIKFFQNQRYHVKHH 673
Cdd:cd00086   1 RRKRTRFTPEQLEELEKEFEKNP-YPSREEREELAKELGLTERQVKIWFQNRRAKLKRS 58
 
Name Accession Description Interval E-value
ULD pfam16534
Ubiquitin-like oligomerization domain of SATB; ULD is an N-terminal oligomerization domain of ...
 58-156 2.45e-52

Ubiquitin-like oligomerization domain of SATB; ULD is an N-terminal oligomerization domain of SATB or special AT-rich sequence-binding proteins. SATBs are global chromatin organizers and regulators of gene expression that are essential for T-cell development, breast cancer tumour growth and metastasis. SATBs assemble into a tetramer via the ULD domain, and the tetramerization of SATBs are essential for recognising specific DNA sequences (such as multiple AT-rich DNA fragments). Thus, SATBs may regulate gene expression directly by binding to various promoters and upstream regions and thereby influencing promoter activity.


Pssm-ID: 465165  Cd Length: 105  Bit Score: 176.38  E-value: 2.45e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38016202    58 LMIPVFCVVEQLDGSLEYDNRE------EHAEFVLVRKDVLFSQLVETALLALGYSHSSAAQAQGIIKLGRWNPLPLSYV 131
Cdd:pfam16534   1 KSLPVHCVVEQVESLQESNECDertpnvEHDSYVIIPKDTLFSDLVETALLRLGYSHSSAAQAKGSIQIKNWKPLSLESI 80

                          90       100
                  ....*....|....*....|....*
gi 38016202   132 TDAPDATVADMLQDVYHVVTLKIQL 156
Cdd:pfam16534  81 TDDPDATVGDMLGDLTTVATLRIQL 105
SATB1_N cd11585
N-terminal domain of SATB1 and similar proteins; SATB1, the special AT-rich sequence-binding ...
 60-155 1.91e-50

N-terminal domain of SATB1 and similar proteins; SATB1, the special AT-rich sequence-binding protein 1, is involved in organizing chromosomal loci into distinct loops, creating a "loopscape" that has a direct bearing on gene expression. This N-terminal domain, which may be involved in various interactions with chromatin proteins, resembles a ubiquitin domain and has been shown to form tetramers, a function critical to SATB1-DNA interactions. The related Drosophila homeobox gene defective proventriculus (dve) plays a key role in the functional specification during endoderm development.


Pssm-ID: 211426  Cd Length: 100  Bit Score: 170.97  E-value: 1.91e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38016202  60 IPVFCVVEQLDGSLE----YDNREEHAEFVLVRKDVLFSQLVETALLALGYSHSSAAQAQGIIKLGRWNPLPLSYVTDAP 135
Cdd:cd11585   1 LPVHCVVETVDSLHEsvwrRRPRVETDSYVIIPKDTLFNQLVETALLRLGYSHSSAASAKGLIQIKNWKPLPFDQITDNP 80

                        90       100
                ....*....|....*....|
gi 38016202 136 DATVADMLQDVYHVVTLKIQ 155
Cdd:cd11585  81 DATVGDMLGELTHVATLRIQ 100
CUTL pfam16557
CUT1-like DNA-binding domain of SATB; CUTL is part of the N-terminal region of SATB proteins, ...
 162-233 1.40e-40

CUT1-like DNA-binding domain of SATB; CUTL is part of the N-terminal region of SATB proteins, special AT-rich sequence-binding proteins that are global chromatin organizers and gene expression regulators essential for T-cell development and breast cancer tumour growth and metastasis. CUTL carries a DNA-binding region just as CUT domains do.


Pssm-ID: 435427  Cd Length: 72  Bit Score: 142.76  E-value: 1.40e-40
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 38016202   162 LEDLPAEQWNHATVRNALKELLKEMNQSTLAKECPLSQSMISSIVNSTYYANVSATKCQEFGRWYKKYKKIK 233
Cdd:pfam16557   1 PELLPPDKWTDQTVRCAVKELLKEMLQSTLAKLCPLTQSMISSIVNSTYYANVSADKCQEFGRWYKQYKKIK 72
CUT pfam02376
CUT domain; The CUT domain is a DNA-binding motif which can bind independently or in ...
 477-556 6.96e-22

CUT domain; The CUT domain is a DNA-binding motif which can bind independently or in cooperation with the homeodomain, often found downstream of the CUT domain. Multiple copies of the CUT domain can exist in one protein.


Pssm-ID: 460543  Cd Length: 78  Bit Score: 89.96  E-value: 6.96e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38016202   477 DGANINiTAAIYDEIQQEMKRAKVSQALFAKVAANKSQGWLCELLRwkeNPSPenrtlWENLCT-------IRRFLNLPQ 549
Cdd:pfam02376   1 DSEELD-TKDIADRIKEELKRHKISQAVFAEKVLNRSQGTLSDLLR---KPKP-----WEKLKSggrtfirMYNWLSLPE 71


                  ....*..
gi 38016202   550 HERDVIY 556
Cdd:pfam02376  72 DERMEIL 78
CUT pfam02376
CUT domain; The CUT domain is a DNA-binding motif which can bind independently or in ...
 355-433 3.02e-19

CUT domain; The CUT domain is a DNA-binding motif which can bind independently or in cooperation with the homeodomain, often found downstream of the CUT domain. Multiple copies of the CUT domain can exist in one protein.


Pssm-ID: 460543  Cd Length: 78  Bit Score: 82.64  E-value: 3.02e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38016202   355 NSSVEVSPDIYQQVRDELKRASVSQAVFARVAFNRTQGLLSEILRKeedPRTASQSLLV--NLRAMQNFLNLPEVERDRI 432
Cdd:pfam02376   1 DSEELDTKDIADRIKEELKRHKISQAVFAEKVLNRSQGTLSDLLRK---PKPWEKLKSGgrTFIRMYNWLSLPEDERMEI 77


                  .
gi 38016202   433 Y 433
Cdd:pfam02376  78 L 78
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 614-671 1.11e-07

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 48.79  E-value: 1.11e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 38016202    614 KPRSRTKISLEALGILQSFIHDvGLYPDQEAIHTLSAQLDLPKHTIIKFFQNQRYHVK 671
Cdd:smart00389   1 KRRKRTSFTPEQLEELEKEFQK-NPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 615-673 7.65e-06

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 43.77  E-value: 7.65e-06
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 38016202 615 PRSRTKISLEALGILQSFIHDVGlYPDQEAIHTLSAQLDLPKHTIIKFFQNQRYHVKHH 673
Cdd:cd00086   1 RRKRTRFTPEQLEELEKEFEKNP-YPSREEREELAKELGLTERQVKIWFQNRRAKLKRS 58
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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