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Conserved domains on  [gi|11128035|ref|NP_061746|]
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protocadherin gamma-B2 isoform 1 precursor [Homo sapiens]

Protein Classification

protocadherin( domain architecture ID 11175791)

protocadherin may have tightly regulated functions in the development, regionalization, and functional differentiation of the central nervous system

CATH:  2.60.40.60
Gene Ontology:  GO:0007156|GO:0005509
PubMed:  28268172|18430161
SCOP:  4007535

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cadherin_2 pfam08266
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.
 32-112 4.50e-36

Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.


:

Pssm-ID: 462413  Cd Length: 83  Bit Score: 130.73  E-value: 4.50e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11128035    32 QIRYSIPEELAKNSVVGNLAKDLGLSVRDLPARKLRV--SAEKEYFTVNPESGDLLVSDRIDREQICGKQPLCVLDFDTV 109
Cdd:pfam08266   1 QIRYSVPEETERGSFVGNLAKDLGLEVGELAARGARVvsKGNKQYFQLNPETGDLLLNEKLDREELCGSTEPCVLHFQVL 80


                  ...
gi 11128035   110 AEN 112
Cdd:pfam08266  81 LEN 83
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 246-342 2.90e-30

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 114.72  E-value: 2.90e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11128035 246 VYRVTLREDVPPGFFVLQVTATDRDEGINAEITYSFhnVDEQVKHFFNLNEKTGEITTKDDLDFEIASSYTLSIEAKDPG 325
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSI--VSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG 78

                        90
                ....*....|....*....
gi 11128035 326 D--LAAHCSIQVEILDDND 342
Cdd:cd11304  79 GppLSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 456-558 5.94e-29

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 111.25  E-value: 5.94e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11128035 456 SYMVHVAENNPPGASIAQISASDPDLGPSGQVSYSIVASDlkpreILSYVSVSAQSGVVFAQRAFDHEQLRAFELTLQAR 535
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGN-----EDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTAT 75

                        90       100
                ....*....|....*....|...
gi 11128035 536 DQGSPALSANVSLRVLVGDLNDN 558
Cdd:cd11304  76 DGGGPPLSSTATVTITVLDVNDN 98
Cadherin_tail super family cl24520
Cadherin C-terminal cytoplasmic tail, catenin-binding region; Cadherin_tail is the cytoplasmic ...
 810-904 6.39e-29

Cadherin C-terminal cytoplasmic tail, catenin-binding region; Cadherin_tail is the cytoplasmic domain at the C-terminus of cadherin proteins. This domain binds p120 catenin, an action critical for the surface stability of cadherin-catenin cell-cell adhesion complexes.


The actual alignment was detected with superfamily member pfam15974:

Pssm-ID: 435046  Cd Length: 134  Bit Score: 112.42  E-value: 6.39e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11128035   810 PPNTDWRFSQAQRPGTSGS-QNGDDTGTWPNNQFDTEMLQAMIlASASEAADGSSTL---GGGAGTMGLSARYGPQFTLQ 885
Cdd:pfam15974   2 PPNPDWRYSASLRAGPMQSsVHMEEAGVLRGGPGGLEQQWPTV-SSATPEPEAGEVSppvGAGVNSNSWTFRYGPGNPKQ 80

                          90       100
                  ....*....|....*....|
gi 11128035   886 HVPD-YRQNVYIPGSNATLT 904
Cdd:pfam15974  81 PVPGeYPENFIIPGSPAIIS 100
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 356-448 1.26e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 107.40  E-value: 1.26e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11128035 356 LPEDSPPGTVIALIKTRDRDSGENGEVYCQVLGNA---KFILKSSSknyYKLVTDGALDREEIPEYNLTITATDGGKPPL 432
Cdd:cd11304   6 VPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNedgLFSIDPST---GEITTAKPLDREEQSSYTLTVTATDGGGPPL 82

                        90
                ....*....|....*.
gi 11128035 433 SSSIIVTLHISDVNDN 448
Cdd:cd11304  83 SSTATVTITVLDVNDN 98
Cadherin_C_2 pfam16492
Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some ...
 688-769 9.80e-24

Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some proto-cadherins. It is this region of the cadherins that allows cell-adhesion and the essential feature of metazoan multicellularity. Cadherins are cell-surface receptors that function in cell adhesion, cell polarity, and tissue morphogenesis.


:

Pssm-ID: 465139  Cd Length: 84  Bit Score: 95.67  E-value: 9.80e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11128035   688 LQFYLVVALALISVLFFLAVILAISLRLRLSSRSDAWDCFQpGLSSKPGPGVLPNYSEGTLP--YSYNLCVASQSAKTEF 765
Cdd:pfam16492   2 LTFYLVIALASVSFLFLLFVIVLIALRLRRWRSSALLQSSG-NLCSVPAPHFPGNDGTGTLPqsYSYEVCLTSDSGKSEF 80


                  ....
gi 11128035   766 NFLN 769
Cdd:pfam16492  81 KFLK 84
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 138-238 2.46e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 92.38  E-value: 2.46e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11128035 138 INLKIGESTKPGTTFPLDPALDSDVGPNSLQRYHL---NDNEYFDLaekqtpdGRKYPELILKHSLDREEHSLHQLVLTA 214
Cdd:cd11304   2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIvsgNEDGLFSI-------DPSTGEITTAKPLDREEQSSYTLTVTA 74

                        90       100
                ....*....|....*....|....
gi 11128035 215 VDGGDPPQSGTTQIRIKVTDANDN 238
Cdd:cd11304  75 TDGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 578-662 4.78e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 88.52  E-value: 4.78e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11128035 578 VPRAAEPGYLVTKVVAVDADSGHNAWLSYHVLQASEPGLFSLGLRTGEVRTARALgDRDAARQ-RLLVAVRDGGQPPLSA 656
Cdd:cd11304   6 VPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPL-DREEQSSyTLTVTATDGGGPPLSS 84


                ....*.
gi 11128035 657 TATLHL 662
Cdd:cd11304  85 TATVTI 90
 
Name Accession Description Interval E-value
Cadherin_2 pfam08266
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.
 32-112 4.50e-36

Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.


Pssm-ID: 462413  Cd Length: 83  Bit Score: 130.73  E-value: 4.50e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11128035    32 QIRYSIPEELAKNSVVGNLAKDLGLSVRDLPARKLRV--SAEKEYFTVNPESGDLLVSDRIDREQICGKQPLCVLDFDTV 109
Cdd:pfam08266   1 QIRYSVPEETERGSFVGNLAKDLGLEVGELAARGARVvsKGNKQYFQLNPETGDLLLNEKLDREELCGSTEPCVLHFQVL 80


                  ...
gi 11128035   110 AEN 112
Cdd:pfam08266  81 LEN 83
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 246-342 2.90e-30

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 114.72  E-value: 2.90e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11128035 246 VYRVTLREDVPPGFFVLQVTATDRDEGINAEITYSFhnVDEQVKHFFNLNEKTGEITTKDDLDFEIASSYTLSIEAKDPG 325
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSI--VSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG 78

                        90
                ....*....|....*....
gi 11128035 326 D--LAAHCSIQVEILDDND 342
Cdd:cd11304  79 GppLSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 456-558 5.94e-29

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 111.25  E-value: 5.94e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11128035 456 SYMVHVAENNPPGASIAQISASDPDLGPSGQVSYSIVASDlkpreILSYVSVSAQSGVVFAQRAFDHEQLRAFELTLQAR 535
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGN-----EDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTAT 75

                        90       100
                ....*....|....*....|...
gi 11128035 536 DQGSPALSANVSLRVLVGDLNDN 558
Cdd:cd11304  76 DGGGPPLSSTATVTITVLDVNDN 98
Cadherin_tail pfam15974
Cadherin C-terminal cytoplasmic tail, catenin-binding region; Cadherin_tail is the cytoplasmic ...
 810-904 6.39e-29

Cadherin C-terminal cytoplasmic tail, catenin-binding region; Cadherin_tail is the cytoplasmic domain at the C-terminus of cadherin proteins. This domain binds p120 catenin, an action critical for the surface stability of cadherin-catenin cell-cell adhesion complexes.


Pssm-ID: 435046  Cd Length: 134  Bit Score: 112.42  E-value: 6.39e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11128035   810 PPNTDWRFSQAQRPGTSGS-QNGDDTGTWPNNQFDTEMLQAMIlASASEAADGSSTL---GGGAGTMGLSARYGPQFTLQ 885
Cdd:pfam15974   2 PPNPDWRYSASLRAGPMQSsVHMEEAGVLRGGPGGLEQQWPTV-SSATPEPEAGEVSppvGAGVNSNSWTFRYGPGNPKQ 80

                          90       100
                  ....*....|....*....|
gi 11128035   886 HVPD-YRQNVYIPGSNATLT 904
Cdd:pfam15974  81 PVPGeYPENFIIPGSPAIIS 100
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 356-448 1.26e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 107.40  E-value: 1.26e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11128035 356 LPEDSPPGTVIALIKTRDRDSGENGEVYCQVLGNA---KFILKSSSknyYKLVTDGALDREEIPEYNLTITATDGGKPPL 432
Cdd:cd11304   6 VPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNedgLFSIDPST---GEITTAKPLDREEQSSYTLTVTATDGGGPPL 82

                        90
                ....*....|....*.
gi 11128035 433 SSSIIVTLHISDVNDN 448
Cdd:cd11304  83 SSTATVTITVLDVNDN 98
Cadherin_C_2 pfam16492
Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some ...
 688-769 9.80e-24

Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some proto-cadherins. It is this region of the cadherins that allows cell-adhesion and the essential feature of metazoan multicellularity. Cadherins are cell-surface receptors that function in cell adhesion, cell polarity, and tissue morphogenesis.


Pssm-ID: 465139  Cd Length: 84  Bit Score: 95.67  E-value: 9.80e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11128035   688 LQFYLVVALALISVLFFLAVILAISLRLRLSSRSDAWDCFQpGLSSKPGPGVLPNYSEGTLP--YSYNLCVASQSAKTEF 765
Cdd:pfam16492   2 LTFYLVIALASVSFLFLLFVIVLIALRLRRWRSSALLQSSG-NLCSVPAPHFPGNDGTGTLPqsYSYEVCLTSDSGKSEF 80


                  ....
gi 11128035   766 NFLN 769
Cdd:pfam16492  81 KFLK 84
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 138-238 2.46e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 92.38  E-value: 2.46e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11128035 138 INLKIGESTKPGTTFPLDPALDSDVGPNSLQRYHL---NDNEYFDLaekqtpdGRKYPELILKHSLDREEHSLHQLVLTA 214
Cdd:cd11304   2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIvsgNEDGLFSI-------DPSTGEITTAKPLDREEQSSYTLTVTA 74

                        90       100
                ....*....|....*....|....
gi 11128035 215 VDGGDPPQSGTTQIRIKVTDANDN 238
Cdd:cd11304  75 TDGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 578-662 4.78e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 88.52  E-value: 4.78e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11128035 578 VPRAAEPGYLVTKVVAVDADSGHNAWLSYHVLQASEPGLFSLGLRTGEVRTARALgDRDAARQ-RLLVAVRDGGQPPLSA 656
Cdd:cd11304   6 VPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPL-DREEQSSyTLTVTATDGGGPPLSS 84


                ....*.
gi 11128035 657 TATLHL 662
Cdd:cd11304  85 TATVTI 90
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 372-450 1.16e-19

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 83.94  E-value: 1.16e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11128035    372 RDRDSGENGEVYCQVLGNA---KFILKSSSKnyyKLVTDGALDREEIPEYNLTITATDGGKPPLSSSIIVTLHISDVNDN 448
Cdd:smart00112   3 TDADSGENGKVTYSILSGNddgLFSIDPETG---EITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDN 79


                   ..
gi 11128035    449 AP 450
Cdd:smart00112  80 AP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 265-345 2.54e-19

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 83.17  E-value: 2.54e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11128035    265 TATDRDEGINAEITYSFhnVDEQVKHFFNLNEKTGEITTKDDLDFEIASSYTLSIEAKDPG--DLAAHCSIQVEILDDND 342
Cdd:smart00112   1 SATDADSGENGKVTYSI--LSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGgpPLSSTATVTITVLDVND 78


                   ...
gi 11128035    343 CAP 345
Cdd:smart00112  79 NAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 475-560 4.13e-19

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 82.40  E-value: 4.13e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11128035    475 SASDPDLGPSGQVSYSIVASDLKpreilSYVSVSAQSGVVFAQRAFDHEQLRAFELTLQARDQGSPALSANVSLRVLVGD 554
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDD-----GLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLD 75


                   ....*.
gi 11128035    555 LNDNAP 560
Cdd:smart00112  76 VNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 157-240 4.40e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 79.70  E-value: 4.40e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11128035    157 ALDSDVGPNSLQRYHLNDNEYFDLAEKQTPDGrkypELILKHSLDREEHSLHQLVLTAVDGGDPPQSGTTQIRIKVTDAN 236
Cdd:smart00112   2 ATDADSGENGKVTYSILSGNDDGLFSIDPETG----EITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVN 77


                   ....
gi 11128035    237 DNPP 240
Cdd:smart00112  78 DNAP 81
Cadherin pfam00028
Cadherin domain;
247-336 3.73e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 77.34  E-value: 3.73e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11128035   247 YRVTLREDVPPGFFVLQVTATDRDEGINAEITYSFHNVDEqvKHFFNLNEKTGEITTKDDLDFEIASSYTLSIEAKDPGD 326
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGP--GGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGG 78

                          90
                  ....*....|....
gi 11128035   327 LA----AHCSIQVE 336
Cdd:pfam00028  79 PPlsstATVTITVL 92
Cadherin pfam00028
Cadherin domain;
457-552 2.39e-16

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 75.03  E-value: 2.39e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11128035   457 YMVHVAENNPPGASIAQISASDPDLGPSGQVSYSIVASDLKPReilsyVSVSAQSGVVFAQRAFDHEQLRAFELTLQARD 536
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGN-----FRIDPDTGDISTTKPLDRESIGEYELTVEATD 75

                          90
                  ....*....|....*.
gi 11128035   537 QGSPALSANVSLRVLV 552
Cdd:pfam00028  76 SGGPPLSSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
356-442 1.56e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 70.02  E-value: 1.56e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11128035   356 LPEDSPPGTVIALIKTRDRDSGENGEVYcqvlgnaKFILKSSSKNYYKLVTD-------GALDREEIPEYNLTITATDGG 428
Cdd:pfam00028   5 VPENAPVGTEVLTVTATDPDLGPNGRIF-------YSILGGGPGGNFRIDPDtgdisttKPLDRESIGEYELTVEATDSG 77

                          90
                  ....*....|....
gi 11128035   429 KPPLSSSIIVTLHI 442
Cdd:pfam00028  78 GPPLSSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 592-663 2.67e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 68.92  E-value: 2.67e-14
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 11128035    592 VAVDADSGHNAWLSYHVLQASEPGLFSLGLRTGEVRTARALgDRDA-ARQRLLVAVRDGGQPPLSATATLHLI 663
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPL-DREEqPEYTLTVEATDGGGPPLSSTATVTIT 72
Cadherin pfam00028
Cadherin domain;
578-661 1.72e-11

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 61.16  E-value: 1.72e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11128035   578 VPRAAEPGYLVTKVVAVDADSGHNAWLSYHVLQASEPGLFSLGLRTGEVRTARALgDRDAARQ-RLLVAVRDGGQPPLSA 656
Cdd:pfam00028   5 VPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPL-DRESIGEyELTVEATDSGGPPLSS 83


                  ....*
gi 11128035   657 TATLH 661
Cdd:pfam00028  84 TATVT 88
Cadherin pfam00028
Cadherin domain;
142-233 2.19e-10

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 58.08  E-value: 2.19e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11128035   142 IGESTKPGTTFPLDPALDSDVGPNSLQRYHL---NDNEYFDLaEKQTPDgrkypeLILKHSLDREEHSLHQLVLTAVDGG 218
Cdd:pfam00028   5 VPENAPVGTEVLTVTATDPDLGPNGRIFYSIlggGPGGNFRI-DPDTGD------ISTTKPLDRESIGEYELTVEATDSG 77

                          90
                  ....*....|....*
gi 11128035   219 DPPQSGTTQIRIKVT 233
Cdd:pfam00028  78 GPPLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 32-129 4.75e-06

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 45.77  E-value: 4.75e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11128035  32 QIRYSIPEELAKNSVVGNL-AKDlglsvRDLPAR-----KLRVSAEKEYFTVNPESGDLLVSDRIDREQICGKQpLCVLD 105
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVsATD-----PDSGENgevtySIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYT-LTVTA 74

                        90       100
                ....*....|....*....|....
gi 11128035 106 FDTVAENPLNIFYIAVIVQDINDN 129
Cdd:cd11304  75 TDGGGPPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 71-131 9.69e-06

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 44.65  E-value: 9.69e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 11128035     71 EKEYFTVNPESGDLLVSDRIDREQIcGKQPLCVLDFDTVAENPLNIFYIAVIVQDINDNTP 131
Cdd:smart00112  22 DDGLFSIDPETGEITTTKPLDREEQ-PEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
 
Name Accession Description Interval E-value
Cadherin_2 pfam08266
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.
 32-112 4.50e-36

Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.


Pssm-ID: 462413  Cd Length: 83  Bit Score: 130.73  E-value: 4.50e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11128035    32 QIRYSIPEELAKNSVVGNLAKDLGLSVRDLPARKLRV--SAEKEYFTVNPESGDLLVSDRIDREQICGKQPLCVLDFDTV 109
Cdd:pfam08266   1 QIRYSVPEETERGSFVGNLAKDLGLEVGELAARGARVvsKGNKQYFQLNPETGDLLLNEKLDREELCGSTEPCVLHFQVL 80


                  ...
gi 11128035   110 AEN 112
Cdd:pfam08266  81 LEN 83
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 246-342 2.90e-30

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 114.72  E-value: 2.90e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11128035 246 VYRVTLREDVPPGFFVLQVTATDRDEGINAEITYSFhnVDEQVKHFFNLNEKTGEITTKDDLDFEIASSYTLSIEAKDPG 325
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSI--VSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG 78

                        90
                ....*....|....*....
gi 11128035 326 D--LAAHCSIQVEILDDND 342
Cdd:cd11304  79 GppLSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 456-558 5.94e-29

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 111.25  E-value: 5.94e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11128035 456 SYMVHVAENNPPGASIAQISASDPDLGPSGQVSYSIVASDlkpreILSYVSVSAQSGVVFAQRAFDHEQLRAFELTLQAR 535
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGN-----EDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTAT 75

                        90       100
                ....*....|....*....|...
gi 11128035 536 DQGSPALSANVSLRVLVGDLNDN 558
Cdd:cd11304  76 DGGGPPLSSTATVTITVLDVNDN 98
Cadherin_tail pfam15974
Cadherin C-terminal cytoplasmic tail, catenin-binding region; Cadherin_tail is the cytoplasmic ...
 810-904 6.39e-29

Cadherin C-terminal cytoplasmic tail, catenin-binding region; Cadherin_tail is the cytoplasmic domain at the C-terminus of cadherin proteins. This domain binds p120 catenin, an action critical for the surface stability of cadherin-catenin cell-cell adhesion complexes.


Pssm-ID: 435046  Cd Length: 134  Bit Score: 112.42  E-value: 6.39e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11128035   810 PPNTDWRFSQAQRPGTSGS-QNGDDTGTWPNNQFDTEMLQAMIlASASEAADGSSTL---GGGAGTMGLSARYGPQFTLQ 885
Cdd:pfam15974   2 PPNPDWRYSASLRAGPMQSsVHMEEAGVLRGGPGGLEQQWPTV-SSATPEPEAGEVSppvGAGVNSNSWTFRYGPGNPKQ 80

                          90       100
                  ....*....|....*....|
gi 11128035   886 HVPD-YRQNVYIPGSNATLT 904
Cdd:pfam15974  81 PVPGeYPENFIIPGSPAIIS 100
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 356-448 1.26e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 107.40  E-value: 1.26e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11128035 356 LPEDSPPGTVIALIKTRDRDSGENGEVYCQVLGNA---KFILKSSSknyYKLVTDGALDREEIPEYNLTITATDGGKPPL 432
Cdd:cd11304   6 VPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNedgLFSIDPST---GEITTAKPLDREEQSSYTLTVTATDGGGPPL 82

                        90
                ....*....|....*.
gi 11128035 433 SSSIIVTLHISDVNDN 448
Cdd:cd11304  83 SSTATVTITVLDVNDN 98
Cadherin_C_2 pfam16492
Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some ...
 688-769 9.80e-24

Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some proto-cadherins. It is this region of the cadherins that allows cell-adhesion and the essential feature of metazoan multicellularity. Cadherins are cell-surface receptors that function in cell adhesion, cell polarity, and tissue morphogenesis.


Pssm-ID: 465139  Cd Length: 84  Bit Score: 95.67  E-value: 9.80e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11128035   688 LQFYLVVALALISVLFFLAVILAISLRLRLSSRSDAWDCFQpGLSSKPGPGVLPNYSEGTLP--YSYNLCVASQSAKTEF 765
Cdd:pfam16492   2 LTFYLVIALASVSFLFLLFVIVLIALRLRRWRSSALLQSSG-NLCSVPAPHFPGNDGTGTLPqsYSYEVCLTSDSGKSEF 80


                  ....
gi 11128035   766 NFLN 769
Cdd:pfam16492  81 KFLK 84
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 138-238 2.46e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 92.38  E-value: 2.46e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11128035 138 INLKIGESTKPGTTFPLDPALDSDVGPNSLQRYHL---NDNEYFDLaekqtpdGRKYPELILKHSLDREEHSLHQLVLTA 214
Cdd:cd11304   2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIvsgNEDGLFSI-------DPSTGEITTAKPLDREEQSSYTLTVTA 74

                        90       100
                ....*....|....*....|....
gi 11128035 215 VDGGDPPQSGTTQIRIKVTDANDN 238
Cdd:cd11304  75 TDGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 578-662 4.78e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 88.52  E-value: 4.78e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11128035 578 VPRAAEPGYLVTKVVAVDADSGHNAWLSYHVLQASEPGLFSLGLRTGEVRTARALgDRDAARQ-RLLVAVRDGGQPPLSA 656
Cdd:cd11304   6 VPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPL-DREEQSSyTLTVTATDGGGPPLSS 84


                ....*.
gi 11128035 657 TATLHL 662
Cdd:cd11304  85 TATVTI 90
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 372-450 1.16e-19

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 83.94  E-value: 1.16e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11128035    372 RDRDSGENGEVYCQVLGNA---KFILKSSSKnyyKLVTDGALDREEIPEYNLTITATDGGKPPLSSSIIVTLHISDVNDN 448
Cdd:smart00112   3 TDADSGENGKVTYSILSGNddgLFSIDPETG---EITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDN 79


                   ..
gi 11128035    449 AP 450
Cdd:smart00112  80 AP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 265-345 2.54e-19

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 83.17  E-value: 2.54e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11128035    265 TATDRDEGINAEITYSFhnVDEQVKHFFNLNEKTGEITTKDDLDFEIASSYTLSIEAKDPG--DLAAHCSIQVEILDDND 342
Cdd:smart00112   1 SATDADSGENGKVTYSI--LSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGgpPLSSTATVTITVLDVND 78


                   ...
gi 11128035    343 CAP 345
Cdd:smart00112  79 NAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 475-560 4.13e-19

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 82.40  E-value: 4.13e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11128035    475 SASDPDLGPSGQVSYSIVASDLKpreilSYVSVSAQSGVVFAQRAFDHEQLRAFELTLQARDQGSPALSANVSLRVLVGD 554
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDD-----GLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLD 75


                   ....*.
gi 11128035    555 LNDNAP 560
Cdd:smart00112  76 VNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 157-240 4.40e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 79.70  E-value: 4.40e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11128035    157 ALDSDVGPNSLQRYHLNDNEYFDLAEKQTPDGrkypELILKHSLDREEHSLHQLVLTAVDGGDPPQSGTTQIRIKVTDAN 236
Cdd:smart00112   2 ATDADSGENGKVTYSILSGNDDGLFSIDPETG----EITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVN 77


                   ....
gi 11128035    237 DNPP 240
Cdd:smart00112  78 DNAP 81
Cadherin pfam00028
Cadherin domain;
247-336 3.73e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 77.34  E-value: 3.73e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11128035   247 YRVTLREDVPPGFFVLQVTATDRDEGINAEITYSFHNVDEqvKHFFNLNEKTGEITTKDDLDFEIASSYTLSIEAKDPGD 326
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGP--GGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGG 78

                          90
                  ....*....|....
gi 11128035   327 LA----AHCSIQVE 336
Cdd:pfam00028  79 PPlsstATVTITVL 92
Cadherin pfam00028
Cadherin domain;
457-552 2.39e-16

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 75.03  E-value: 2.39e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11128035   457 YMVHVAENNPPGASIAQISASDPDLGPSGQVSYSIVASDLKPReilsyVSVSAQSGVVFAQRAFDHEQLRAFELTLQARD 536
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGN-----FRIDPDTGDISTTKPLDRESIGEYELTVEATD 75

                          90
                  ....*....|....*.
gi 11128035   537 QGSPALSANVSLRVLV 552
Cdd:pfam00028  76 SGGPPLSSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
356-442 1.56e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 70.02  E-value: 1.56e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11128035   356 LPEDSPPGTVIALIKTRDRDSGENGEVYcqvlgnaKFILKSSSKNYYKLVTD-------GALDREEIPEYNLTITATDGG 428
Cdd:pfam00028   5 VPENAPVGTEVLTVTATDPDLGPNGRIF-------YSILGGGPGGNFRIDPDtgdisttKPLDRESIGEYELTVEATDSG 77

                          90
                  ....*....|....
gi 11128035   429 KPPLSSSIIVTLHI 442
Cdd:pfam00028  78 GPPLSSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 592-663 2.67e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 68.92  E-value: 2.67e-14
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 11128035    592 VAVDADSGHNAWLSYHVLQASEPGLFSLGLRTGEVRTARALgDRDA-ARQRLLVAVRDGGQPPLSATATLHLI 663
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPL-DREEqPEYTLTVEATDGGGPPLSSTATVTIT 72
Cadherin pfam00028
Cadherin domain;
578-661 1.72e-11

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 61.16  E-value: 1.72e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11128035   578 VPRAAEPGYLVTKVVAVDADSGHNAWLSYHVLQASEPGLFSLGLRTGEVRTARALgDRDAARQ-RLLVAVRDGGQPPLSA 656
Cdd:pfam00028   5 VPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPL-DRESIGEyELTVEATDSGGPPLSS 83


                  ....*
gi 11128035   657 TATLH 661
Cdd:pfam00028  84 TATVT 88
Cadherin pfam00028
Cadherin domain;
142-233 2.19e-10

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 58.08  E-value: 2.19e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11128035   142 IGESTKPGTTFPLDPALDSDVGPNSLQRYHL---NDNEYFDLaEKQTPDgrkypeLILKHSLDREEHSLHQLVLTAVDGG 218
Cdd:pfam00028   5 VPENAPVGTEVLTVTATDPDLGPNGRIFYSIlggGPGGNFRI-DPDTGD------ISTTKPLDRESIGEYELTVEATDSG 77

                          90
                  ....*....|....*
gi 11128035   219 DPPQSGTTQIRIKVT 233
Cdd:pfam00028  78 GPPLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 32-129 4.75e-06

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 45.77  E-value: 4.75e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11128035  32 QIRYSIPEELAKNSVVGNL-AKDlglsvRDLPAR-----KLRVSAEKEYFTVNPESGDLLVSDRIDREQICGKQpLCVLD 105
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVsATD-----PDSGENgevtySIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYT-LTVTA 74

                        90       100
                ....*....|....*....|....
gi 11128035 106 FDTVAENPLNIFYIAVIVQDINDN 129
Cdd:cd11304  75 TDGGGPPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 71-131 9.69e-06

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 44.65  E-value: 9.69e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 11128035     71 EKEYFTVNPESGDLLVSDRIDREQIcGKQPLCVLDFDTVAENPLNIFYIAVIVQDINDNTP 131
Cdd:smart00112  22 DDGLFSIDPETGEITTTKPLDREEQ-PEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 33-129 1.22e-05

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 44.64  E-value: 1.22e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11128035  33 IRYSIPEELAKNSVVGNLAKDLGLSVRDLpARKLRVSAEK--EYFTVNPESGDLLVSDRIDREQICgKQPLCVLDFDTVA 110
Cdd:cd00031   2 PDGSAVEGRSRGSFRVSIPTDLIASSGEI-IKISAAGKEAlpSWLHWEPHSGILEGLEKLDREDKG-VHYISVSAASLGA 79

                        90
                ....*....|....*....
gi 11128035 111 ENPLNIFYIAVIVQDINDN 129
Cdd:cd00031  80 NVPQTSSVFSIEVYDENDN 98
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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