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Conserved domains on  [gi|67782362|ref|NP_061903|]
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ATP-dependent RNA helicase DHX29 isoform 1 [Homo sapiens]

Protein Classification

DEAD/DEAH box helicase( domain architecture ID 1000776)

DEAD/DEAH box containing ATP-dependent helicase catalyzes the unwinding of DNA or RNA; similar to ATP-dependent RNA helicase that is involved in translation initiation

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
DEXHc_DHX29 cd17975
DEXH-box helicase domain of DEAH-box helicase 29; DEAH-box helicase 29 (DHX29) is a part of ...
572-754 1.81e-130

DEXH-box helicase domain of DEAH-box helicase 29; DEAH-box helicase 29 (DHX29) is a part of the 43S pre-initiation complex involved in translation initiation of mRNAs with structured 5'-UTRs. DHX29 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


:

Pssm-ID: 350733 [Multi-domain]  Cd Length: 183  Bit Score: 399.29  E-value: 1.81e-130
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362  572 LPVFKHRDSIVETLKRHRVVVVAGETGSGKSTQVPHFLLEDLLLNEWEASKCNIVCTQPRRISAVSLANRVCDELGCENG 651
Cdd:cd17975    1 LPVFKHRESILETLKRHRVVVVAGETGSGKSTQVPQFLLEDLLLNGGTAQKCNIVCTQPRRISAMSLATRVCEELGCESG 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362  652 PGGRNSLCGYQIRMESRACESTRLLYCTTGVLLRKLQEDGLLSNVSHVIVDEVHERSVQSDFLLIILKEILQKRSDLHLI 731
Cdd:cd17975   81 PGGKNSLCGYQIRMESRTGEATRLLYCTTGVLLRKLQEDGLLSSISHIIVDEVHERSVQSDFLLIILKEILHKRSDLHLI 160
                        170       180
                 ....*....|....*....|...
gi 67782362  732 LMSATVDSEKFSTYFTHCPILRI 754
Cdd:cd17975  161 LMSATVDCEKFSSYFTHCPILRI 183
HrpA super family cl34328
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];
571-1271 8.62e-126

HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];


The actual alignment was detected with superfamily member COG1643:

Pssm-ID: 441249 [Multi-domain]  Cd Length: 836  Bit Score: 410.63  E-value: 8.62e-126
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362  571 QLPVFKHRDSIVETLKRHRVVVVAGETGSGKSTQVPHFLLEdlllNEWEASKcNIVCTQPRRISAVSLANRVCDELGCEn 650
Cdd:COG1643    9 DLPVSAVLPELLAALRAHQVVVLAAPPGAGKTTQLPLALLE----LGWGAGG-RIGMLEPRRLAARAAAERMAEELGEP- 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362  651 gPGGRnslCGYQIRMESRACESTRLLYCTTGVLLRKLQEDGLLSNVSHVIVDEVHERSVQSDFLLIILKEILQK-RSDLH 729
Cdd:COG1643   83 -VGET---VGYRVRFEDKVSAATRIEVVTEGILLRELQRDPELEGVDTVIFDEFHERSLNADLLLALLLDLQPAlRPDLK 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362  730 LILMSATVDSEKFSTYFTHCPILRISGRSYPVEVfhlediieetgfvlekdseycqkfleeeeevtinvtskaggikkyq 809
Cdd:COG1643  159 LLVMSATLDAERFARLLGDAPVIESSGRTYPVEV---------------------------------------------- 192
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362  810 EYIPVQTGAhADLNPfyqkyssrtqhAIlymnphkinLDLILELLayldkspqfRNIEGAVLIFLPGLAHIQQLYDLLsn 889
Cdd:COG1643  193 RYRPLPADE-RDLED-----------AV---------ADAVREAL---------AEEPGDILVFLPGEREIRRTAEAL-- 240
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362  890 dRRFYSERYKVIALHSILSTQDQAAAFTLPPPGVRKIVLATNIAETGITIPDVVFVIDTGRTKENKYHESSQMSSLVETF 969
Cdd:COG1643  241 -RGRLPPDTEILPLYGRLSAAEQDRAFAPAPHGRRRIVLATNIAETSLTVPGIRYVIDSGLARIPRYDPRSGVTRLPTER 319
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362  970 VSKASALQRQGRAGRVRDGFCFRMYTRERFEGFMDYSVPEILRVPLEELCLHiMKC-NLGSPEDFlsKALDPPQLQVISN 1048
Cdd:COG1643  320 ISQASANQRAGRAGRLAPGICYRLWSEEDFARRPAFTDPEILRADLASLILE-LAAwGLGDPEDL--PFLDPPPARAIAD 396
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362 1049 AMNLLRKIGACElNEPKLTPLGQHLAALPVNVKIGKMLIFGAIFGCLDPVATLAAVMTEKSPFttpigRKDeadlaksal 1128
Cdd:COG1643  397 ARALLQELGALD-ADGRLTPLGRALARLPLDPRLARMLLAAAELGCLREAAILAALLSERDPR-----RGA--------- 461
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362 1129 amADSDHLTIYNAylgWKKARQEggyrseitycRRNFLNRTSLLTLEDVKQELIKLVKAAgfsssttstswegnRASQTL 1208
Cdd:COG1643  462 --AGSDLLARLNL---WRRLREQ----------QREFLSYLRLREWRDLARQLRRLLGEG--------------ANEEPA 512
                        650       660       670       680       690       700
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 67782362 1209 SFQEIALLkavLVAGLYDNVGKiiytKSVDVTE-KLACivetaQGKAQVHPSSvnrDLQTHGWL 1271
Cdd:COG1643  513 DYEAIGLL---LALAYPDRIAR----RRGEGGRyLLAR-----GRGAALFPGS---PLAKKEWL 561
 
Name Accession Description Interval E-value
DEXHc_DHX29 cd17975
DEXH-box helicase domain of DEAH-box helicase 29; DEAH-box helicase 29 (DHX29) is a part of ...
572-754 1.81e-130

DEXH-box helicase domain of DEAH-box helicase 29; DEAH-box helicase 29 (DHX29) is a part of the 43S pre-initiation complex involved in translation initiation of mRNAs with structured 5'-UTRs. DHX29 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350733 [Multi-domain]  Cd Length: 183  Bit Score: 399.29  E-value: 1.81e-130
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362  572 LPVFKHRDSIVETLKRHRVVVVAGETGSGKSTQVPHFLLEDLLLNEWEASKCNIVCTQPRRISAVSLANRVCDELGCENG 651
Cdd:cd17975    1 LPVFKHRESILETLKRHRVVVVAGETGSGKSTQVPQFLLEDLLLNGGTAQKCNIVCTQPRRISAMSLATRVCEELGCESG 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362  652 PGGRNSLCGYQIRMESRACESTRLLYCTTGVLLRKLQEDGLLSNVSHVIVDEVHERSVQSDFLLIILKEILQKRSDLHLI 731
Cdd:cd17975   81 PGGKNSLCGYQIRMESRTGEATRLLYCTTGVLLRKLQEDGLLSSISHIIVDEVHERSVQSDFLLIILKEILHKRSDLHLI 160
                        170       180
                 ....*....|....*....|...
gi 67782362  732 LMSATVDSEKFSTYFTHCPILRI 754
Cdd:cd17975  161 LMSATVDCEKFSSYFTHCPILRI 183
HrpA COG1643
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];
571-1271 8.62e-126

HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441249 [Multi-domain]  Cd Length: 836  Bit Score: 410.63  E-value: 8.62e-126
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362  571 QLPVFKHRDSIVETLKRHRVVVVAGETGSGKSTQVPHFLLEdlllNEWEASKcNIVCTQPRRISAVSLANRVCDELGCEn 650
Cdd:COG1643    9 DLPVSAVLPELLAALRAHQVVVLAAPPGAGKTTQLPLALLE----LGWGAGG-RIGMLEPRRLAARAAAERMAEELGEP- 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362  651 gPGGRnslCGYQIRMESRACESTRLLYCTTGVLLRKLQEDGLLSNVSHVIVDEVHERSVQSDFLLIILKEILQK-RSDLH 729
Cdd:COG1643   83 -VGET---VGYRVRFEDKVSAATRIEVVTEGILLRELQRDPELEGVDTVIFDEFHERSLNADLLLALLLDLQPAlRPDLK 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362  730 LILMSATVDSEKFSTYFTHCPILRISGRSYPVEVfhlediieetgfvlekdseycqkfleeeeevtinvtskaggikkyq 809
Cdd:COG1643  159 LLVMSATLDAERFARLLGDAPVIESSGRTYPVEV---------------------------------------------- 192
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362  810 EYIPVQTGAhADLNPfyqkyssrtqhAIlymnphkinLDLILELLayldkspqfRNIEGAVLIFLPGLAHIQQLYDLLsn 889
Cdd:COG1643  193 RYRPLPADE-RDLED-----------AV---------ADAVREAL---------AEEPGDILVFLPGEREIRRTAEAL-- 240
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362  890 dRRFYSERYKVIALHSILSTQDQAAAFTLPPPGVRKIVLATNIAETGITIPDVVFVIDTGRTKENKYHESSQMSSLVETF 969
Cdd:COG1643  241 -RGRLPPDTEILPLYGRLSAAEQDRAFAPAPHGRRRIVLATNIAETSLTVPGIRYVIDSGLARIPRYDPRSGVTRLPTER 319
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362  970 VSKASALQRQGRAGRVRDGFCFRMYTRERFEGFMDYSVPEILRVPLEELCLHiMKC-NLGSPEDFlsKALDPPQLQVISN 1048
Cdd:COG1643  320 ISQASANQRAGRAGRLAPGICYRLWSEEDFARRPAFTDPEILRADLASLILE-LAAwGLGDPEDL--PFLDPPPARAIAD 396
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362 1049 AMNLLRKIGACElNEPKLTPLGQHLAALPVNVKIGKMLIFGAIFGCLDPVATLAAVMTEKSPFttpigRKDeadlaksal 1128
Cdd:COG1643  397 ARALLQELGALD-ADGRLTPLGRALARLPLDPRLARMLLAAAELGCLREAAILAALLSERDPR-----RGA--------- 461
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362 1129 amADSDHLTIYNAylgWKKARQEggyrseitycRRNFLNRTSLLTLEDVKQELIKLVKAAgfsssttstswegnRASQTL 1208
Cdd:COG1643  462 --AGSDLLARLNL---WRRLREQ----------QREFLSYLRLREWRDLARQLRRLLGEG--------------ANEEPA 512
                        650       660       670       680       690       700
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 67782362 1209 SFQEIALLkavLVAGLYDNVGKiiytKSVDVTE-KLACivetaQGKAQVHPSSvnrDLQTHGWL 1271
Cdd:COG1643  513 DYEAIGLL---LALAYPDRIAR----RRGEGGRyLLAR-----GRGAALFPGS---PLAKKEWL 561
PRK11131 PRK11131
ATP-dependent RNA helicase HrpA; Provisional
570-1190 2.77e-89

ATP-dependent RNA helicase HrpA; Provisional


Pssm-ID: 182986 [Multi-domain]  Cd Length: 1294  Bit Score: 317.39  E-value: 2.77e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362   570 QQLPVFKHRDSIVETLKRHRVVVVAGETGSGKSTQVPHFLLEdllLNEweASKCNIVCTQPRRISAVSLANRVCDELGCE 649
Cdd:PRK11131   71 ENLPVSQKKQDILEAIRDHQVVIVAGETGSGKTTQLPKICLE---LGR--GVKGLIGHTQPRRLAARTVANRIAEELETE 145
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362   650 NGpggrnSLCGYQIRMESRACESTRLLYCTTGVLLRKLQEDGLLSNVSHVIVDEVHERSVQSDFLLIILKEILQKRSDLH 729
Cdd:PRK11131  146 LG-----GCVGYKVRFNDQVSDNTMVKLMTDGILLAEIQQDRLLMQYDTIIIDEAHERSLNIDFILGYLKELLPRRPDLK 220
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362   730 LILMSATVDSEKFSTYFTHCPILRISGRSYPVEVfhlediieetgfvlekdseycqkfleeeeevtinvtskaggikkyq 809
Cdd:PRK11131  221 VIITSATIDPERFSRHFNNAPIIEVSGRTYPVEV---------------------------------------------- 254
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362   810 EYIPVQTGAHAdlnpfyqkySSRTQ-HAIlymnphkinLDLILELLAyldKSPqfrnieGAVLIFLPGLAHIQQLYDLLS 888
Cdd:PRK11131  255 RYRPIVEEADD---------TERDQlQAI---------FDAVDELGR---EGP------GDILIFMSGEREIRDTADALN 307
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362   889 NDRRFYSErykVIALHSILSTQDQAAAFTlpPPGVRKIVLATNIAETGITIPDVVFVIDTGRTKENKYHESSQMSSLVET 968
Cdd:PRK11131  308 KLNLRHTE---ILPLYARLSNSEQNRVFQ--SHSGRRIVLATNVAETSLTVPGIKYVIDPGTARISRYSYRTKVQRLPIE 382
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362   969 FVSKASALQRQGRAGRVRDGFCFRMYTRERFEGFMDYSVPEILRVPLEELCLHIMKCNLGSPEDFlsKALDPPQLQVISN 1048
Cdd:PRK11131  383 PISQASANQRKGRCGRVSEGICIRLYSEDDFLSRPEFTDPEILRTNLASVILQMTALGLGDIAAF--PFVEAPDKRNIQD 460
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362  1049 AMNLLRKIGACELNEP----KLTPLGQHLAALPVNVKIGKMLIFGAIFGCLDPVATLAAVMTEKSPFTTPIGRKDEADLA 1124
Cdd:PRK11131  461 GVRLLEELGAITTDEQasayKLTPLGRQLAQLPVDPRLARMVLEAQKHGCVREVMIITSALSIQDPRERPMDKQQASDEK 540
                         570       580       590       600       610       620
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 67782362  1125 KSALAMADSDHLTIYNA--YLG-WKKARQEGGYRSEityCRRNFLNRTSLLTLEDVKQELIKLVKAAGF 1190
Cdd:PRK11131  541 HRRFADKESDFLAFVNLwnYLQeQQKALSSNQFRRL---CRTDYLNYLRVREWQDIYTQLRQVVKELGI 606
SF2_C_RHA cd18791
C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A ...
837-994 2.84e-67

C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family members are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350178 [Multi-domain]  Cd Length: 171  Bit Score: 223.95  E-value: 2.84e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362  837 ILYMNPHKINLDLILELLAYLDKSpqfrNIEGAVLIFLPGLAHIQQLYDLL-SNDRRFYSERYKVIALHSILSTQDQAAA 915
Cdd:cd18791   17 ISSEKEDPDYVDAAVRLILQIHRT----EEPGDILVFLPGQEEIERLCELLrEELLSPDLGKLLVLPLHSSLPPEEQQRV 92
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 67782362  916 FTLPPPGVRKIVLATNIAETGITIPDVVFVIDTGRTKENKYHESSQMSSLVETFVSKASALQRQGRAGRVRDGFCFRMY 994
Cdd:cd18791   93 FEPPPPGVRKVVLATNIAETSITIPGVVYVIDSGLVKEKVYDPRTGLSSLVTVWISKASAEQRAGRAGRTRPGKCYRLY 171
DEXDc smart00487
DEAD-like helicases superfamily;
578-764 1.24e-24

DEAD-like helicases superfamily;


Pssm-ID: 214692 [Multi-domain]  Cd Length: 201  Bit Score: 102.96  E-value: 1.24e-24
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362     578 RDSIVETLKRHRVVVVAGETGSGKSTQVPHFLLEDLLlnewEASKCNIVCTQPRRisavSLANRVCDELGCENGPGGRNS 657
Cdd:smart00487   14 KEAIEALLSGLRDVILAAPTGSGKTLAALLPALEALK----RGKGGRVLVLVPTR----ELAEQWAEELKKLGPSLGLKV 85
                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362     658 LC---GYQIRMESRACES--TRLLYCTTGVLLRKLQEDGL-LSNVSHVIVDEVHERSVQsDFLLIILKEILQKRSDLHLI 731
Cdd:smart00487   86 VGlygGDSKREQLRKLESgkTDILVTTPGRLLDLLENDKLsLSNVDLVILDEAHRLLDG-GFGDQLEKLLKLLPKNVQLL 164
                           170       180       190
                    ....*....|....*....|....*....|....*..
gi 67782362     732 LMSAT--VDSEKFSTYFTHCP--ILRISGRSYPVEVF 764
Cdd:smart00487  165 LLSATppEEIENLLELFLNDPvfIDVGFTPLEPIEQF 201
HA2 pfam04408
Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in ...
1049-1138 8.46e-21

Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.


Pssm-ID: 461295 [Multi-domain]  Cd Length: 104  Bit Score: 88.45  E-value: 8.46e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362   1049 AMNLLRKIGAceLNE-PKLTPLGQHLAALPVNVKIGKMLIFGAIFGCLDPVATLAAVMTEKSPFTTPIG----------- 1116
Cdd:pfam04408    1 ALELLYYLGA--LDEdGELTPLGRKMAELPLDPRLAKMLLAAAELGCLDEVLTIVAALSVRDPFVQPNFldprsaakaar 78
                           90       100
                   ....*....|....*....|....*.
gi 67782362   1117 ----RKDEADLAKSALAMADSDHLTI 1138
Cdd:pfam04408   79 rrrrAADEKARAKFARLDLEGDHLTL 104
HA2 smart00847
Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino ...
1056-1137 1.89e-20

Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.


Pssm-ID: 214852 [Multi-domain]  Cd Length: 82  Bit Score: 86.94  E-value: 1.89e-20
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362    1056 IGACELNEpKLTPLGQHLAALPVNVKIGKMLIFGAIFGCLDPVATLAAVMTEKSPFttPIGRKDEADLAKSALAMADSDH 1135
Cdd:smart00847    2 LGALDDDG-RLTPLGRKMAELPLDPRLAKMLLAAAEFGCLDEILTIVAMLSVGDPR--PKEKREDADAARRRFADPESDH 78

                    ..
gi 67782362    1136 LT 1137
Cdd:smart00847   79 LT 80
DEAD pfam00270
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ...
580-740 6.14e-13

DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.


Pssm-ID: 425570 [Multi-domain]  Cd Length: 165  Bit Score: 68.04  E-value: 6.14e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362    580 SIVETLKRHRVVVVAGETGSGKST--QVPhflLEDLLLNEWEASKCNIVCtqPRRisavSLAN---RVCDELGCENGPGG 654
Cdd:pfam00270    6 EAIPAILEGRDVLVQAPTGSGKTLafLLP---ALEALDKLDNGPQALVLA--PTR----ELAEqiyEELKKLGKGLGLKV 76
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362    655 RNSLCGYQIRMESRACESTRLLYCTTGVLLRKLQEDGLLSNVSHVIVDEVHeRSVQSDFLLIILKEILQKRSDLHLILMS 734
Cdd:pfam00270   77 ASLLGGDSRKEQLEKLKGPDILVGTPGRLLDLLQERKLLKNLKLLVLDEAH-RLLDMGFGPDLEEILRRLPKKRQILLLS 155

                   ....*.
gi 67782362    735 ATVDSE 740
Cdd:pfam00270  156 ATLPRN 161
 
Name Accession Description Interval E-value
DEXHc_DHX29 cd17975
DEXH-box helicase domain of DEAH-box helicase 29; DEAH-box helicase 29 (DHX29) is a part of ...
572-754 1.81e-130

DEXH-box helicase domain of DEAH-box helicase 29; DEAH-box helicase 29 (DHX29) is a part of the 43S pre-initiation complex involved in translation initiation of mRNAs with structured 5'-UTRs. DHX29 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350733 [Multi-domain]  Cd Length: 183  Bit Score: 399.29  E-value: 1.81e-130
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362  572 LPVFKHRDSIVETLKRHRVVVVAGETGSGKSTQVPHFLLEDLLLNEWEASKCNIVCTQPRRISAVSLANRVCDELGCENG 651
Cdd:cd17975    1 LPVFKHRESILETLKRHRVVVVAGETGSGKSTQVPQFLLEDLLLNGGTAQKCNIVCTQPRRISAMSLATRVCEELGCESG 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362  652 PGGRNSLCGYQIRMESRACESTRLLYCTTGVLLRKLQEDGLLSNVSHVIVDEVHERSVQSDFLLIILKEILQKRSDLHLI 731
Cdd:cd17975   81 PGGKNSLCGYQIRMESRTGEATRLLYCTTGVLLRKLQEDGLLSSISHIIVDEVHERSVQSDFLLIILKEILHKRSDLHLI 160
                        170       180
                 ....*....|....*....|...
gi 67782362  732 LMSATVDSEKFSTYFTHCPILRI 754
Cdd:cd17975  161 LMSATVDCEKFSSYFTHCPILRI 183
HrpA COG1643
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];
571-1271 8.62e-126

HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441249 [Multi-domain]  Cd Length: 836  Bit Score: 410.63  E-value: 8.62e-126
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362  571 QLPVFKHRDSIVETLKRHRVVVVAGETGSGKSTQVPHFLLEdlllNEWEASKcNIVCTQPRRISAVSLANRVCDELGCEn 650
Cdd:COG1643    9 DLPVSAVLPELLAALRAHQVVVLAAPPGAGKTTQLPLALLE----LGWGAGG-RIGMLEPRRLAARAAAERMAEELGEP- 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362  651 gPGGRnslCGYQIRMESRACESTRLLYCTTGVLLRKLQEDGLLSNVSHVIVDEVHERSVQSDFLLIILKEILQK-RSDLH 729
Cdd:COG1643   83 -VGET---VGYRVRFEDKVSAATRIEVVTEGILLRELQRDPELEGVDTVIFDEFHERSLNADLLLALLLDLQPAlRPDLK 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362  730 LILMSATVDSEKFSTYFTHCPILRISGRSYPVEVfhlediieetgfvlekdseycqkfleeeeevtinvtskaggikkyq 809
Cdd:COG1643  159 LLVMSATLDAERFARLLGDAPVIESSGRTYPVEV---------------------------------------------- 192
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362  810 EYIPVQTGAhADLNPfyqkyssrtqhAIlymnphkinLDLILELLayldkspqfRNIEGAVLIFLPGLAHIQQLYDLLsn 889
Cdd:COG1643  193 RYRPLPADE-RDLED-----------AV---------ADAVREAL---------AEEPGDILVFLPGEREIRRTAEAL-- 240
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362  890 dRRFYSERYKVIALHSILSTQDQAAAFTLPPPGVRKIVLATNIAETGITIPDVVFVIDTGRTKENKYHESSQMSSLVETF 969
Cdd:COG1643  241 -RGRLPPDTEILPLYGRLSAAEQDRAFAPAPHGRRRIVLATNIAETSLTVPGIRYVIDSGLARIPRYDPRSGVTRLPTER 319
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362  970 VSKASALQRQGRAGRVRDGFCFRMYTRERFEGFMDYSVPEILRVPLEELCLHiMKC-NLGSPEDFlsKALDPPQLQVISN 1048
Cdd:COG1643  320 ISQASANQRAGRAGRLAPGICYRLWSEEDFARRPAFTDPEILRADLASLILE-LAAwGLGDPEDL--PFLDPPPARAIAD 396
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362 1049 AMNLLRKIGACElNEPKLTPLGQHLAALPVNVKIGKMLIFGAIFGCLDPVATLAAVMTEKSPFttpigRKDeadlaksal 1128
Cdd:COG1643  397 ARALLQELGALD-ADGRLTPLGRALARLPLDPRLARMLLAAAELGCLREAAILAALLSERDPR-----RGA--------- 461
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362 1129 amADSDHLTIYNAylgWKKARQEggyrseitycRRNFLNRTSLLTLEDVKQELIKLVKAAgfsssttstswegnRASQTL 1208
Cdd:COG1643  462 --AGSDLLARLNL---WRRLREQ----------QREFLSYLRLREWRDLARQLRRLLGEG--------------ANEEPA 512
                        650       660       670       680       690       700
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 67782362 1209 SFQEIALLkavLVAGLYDNVGKiiytKSVDVTE-KLACivetaQGKAQVHPSSvnrDLQTHGWL 1271
Cdd:COG1643  513 DYEAIGLL---LALAYPDRIAR----RRGEGGRyLLAR-----GRGAALFPGS---PLAKKEWL 561
PRK11131 PRK11131
ATP-dependent RNA helicase HrpA; Provisional
570-1190 2.77e-89

ATP-dependent RNA helicase HrpA; Provisional


Pssm-ID: 182986 [Multi-domain]  Cd Length: 1294  Bit Score: 317.39  E-value: 2.77e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362   570 QQLPVFKHRDSIVETLKRHRVVVVAGETGSGKSTQVPHFLLEdllLNEweASKCNIVCTQPRRISAVSLANRVCDELGCE 649
Cdd:PRK11131   71 ENLPVSQKKQDILEAIRDHQVVIVAGETGSGKTTQLPKICLE---LGR--GVKGLIGHTQPRRLAARTVANRIAEELETE 145
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362   650 NGpggrnSLCGYQIRMESRACESTRLLYCTTGVLLRKLQEDGLLSNVSHVIVDEVHERSVQSDFLLIILKEILQKRSDLH 729
Cdd:PRK11131  146 LG-----GCVGYKVRFNDQVSDNTMVKLMTDGILLAEIQQDRLLMQYDTIIIDEAHERSLNIDFILGYLKELLPRRPDLK 220
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362   730 LILMSATVDSEKFSTYFTHCPILRISGRSYPVEVfhlediieetgfvlekdseycqkfleeeeevtinvtskaggikkyq 809
Cdd:PRK11131  221 VIITSATIDPERFSRHFNNAPIIEVSGRTYPVEV---------------------------------------------- 254
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362   810 EYIPVQTGAHAdlnpfyqkySSRTQ-HAIlymnphkinLDLILELLAyldKSPqfrnieGAVLIFLPGLAHIQQLYDLLS 888
Cdd:PRK11131  255 RYRPIVEEADD---------TERDQlQAI---------FDAVDELGR---EGP------GDILIFMSGEREIRDTADALN 307
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362   889 NDRRFYSErykVIALHSILSTQDQAAAFTlpPPGVRKIVLATNIAETGITIPDVVFVIDTGRTKENKYHESSQMSSLVET 968
Cdd:PRK11131  308 KLNLRHTE---ILPLYARLSNSEQNRVFQ--SHSGRRIVLATNVAETSLTVPGIKYVIDPGTARISRYSYRTKVQRLPIE 382
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362   969 FVSKASALQRQGRAGRVRDGFCFRMYTRERFEGFMDYSVPEILRVPLEELCLHIMKCNLGSPEDFlsKALDPPQLQVISN 1048
Cdd:PRK11131  383 PISQASANQRKGRCGRVSEGICIRLYSEDDFLSRPEFTDPEILRTNLASVILQMTALGLGDIAAF--PFVEAPDKRNIQD 460
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362  1049 AMNLLRKIGACELNEP----KLTPLGQHLAALPVNVKIGKMLIFGAIFGCLDPVATLAAVMTEKSPFTTPIGRKDEADLA 1124
Cdd:PRK11131  461 GVRLLEELGAITTDEQasayKLTPLGRQLAQLPVDPRLARMVLEAQKHGCVREVMIITSALSIQDPRERPMDKQQASDEK 540
                         570       580       590       600       610       620
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 67782362  1125 KSALAMADSDHLTIYNA--YLG-WKKARQEGGYRSEityCRRNFLNRTSLLTLEDVKQELIKLVKAAGF 1190
Cdd:PRK11131  541 HRRFADKESDFLAFVNLwnYLQeQQKALSSNQFRRL---CRTDYLNYLRVREWQDIYTQLRQVVKELGI 606
DEXHc_RHA-like cd17917
DEXH-box helicase domain of DEAD-like helicase RHA family proteins; The RNA helicase A (RHA) ...
588-754 1.31e-86

DEXH-box helicase domain of DEAD-like helicase RHA family proteins; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 438707 [Multi-domain]  Cd Length: 159  Bit Score: 278.57  E-value: 1.31e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362  588 HRVVVVAGETGSGKSTQVPHFLLEDLLLNEweaSKCNIVCTQPRRISAVSLANRVCDELGCENGpggrnSLCGYQIRMES 667
Cdd:cd17917    1 NQVVVIVGETGSGKTTQVPQFLLEDGLAKG---GKGRIVCTQPRRIAAISVAERVAEERGEKLG-----EEVGYQIRFES 72
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362  668 RACESTRLLYCTTGVLLRKLQEDGLLSNVSHVIVDEVHERSVQSDFLLIILKEILQKRSDLHLILMSATVDSEKFSTYFT 747
Cdd:cd17917   73 KTSSKTRIKFCTDGILLRELLSDPLLSGYSHVILDEAHERSLDTDFLLGLLKDLLRKRPDLKVILMSATLDAEKFSSYFG 152

                 ....*..
gi 67782362  748 HCPILRI 754
Cdd:cd17917  153 GAPVIHI 159
DEXHc_DHX30 cd17976
DEXH-box helicase domain of DEAH-box helicase 30; DEAH-box helicase 30 (DHX30) plays an ...
572-754 8.16e-69

DEXH-box helicase domain of DEAH-box helicase 30; DEAH-box helicase 30 (DHX30) plays an important role in the assembly of the mitochondrial large ribosomal subunit. DHX30 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350734 [Multi-domain]  Cd Length: 178  Bit Score: 228.91  E-value: 8.16e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362  572 LPVFKHRDSIVETLKRHRVVVVAGETGSGKSTQVPHFLLEDLLLnEWEASKCNIVCTQPRRISAVSLANRVCDELGceng 651
Cdd:cd17976    1 LPVDSHKESILSAIEQNPVVVISGDTGCGKTTRIPQFILEDYVL-RGRGARCNVVITQPRRISAVSVAQRVAHELG---- 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362  652 PGGRNSLcGYQIRMESRACEST-RLLYCTTGVLLRKLQEDGLLSNVSHVIVDEVHERSVQSDFLLIILKEILQKRSDLHL 730
Cdd:cd17976   76 PNLRRNV-GYQVRLESRPPPRGgALLFCTVGVLLKKLQSNPRLEGVSHVIVDEVHERDVNTDFLLILLKGVLQLNPELRV 154
                        170       180
                 ....*....|....*....|....
gi 67782362  731 ILMSATVDSEKFSTYFTHCPILRI 754
Cdd:cd17976  155 VLMSATGDNQRLSRYFGGCPVVRV 178
SF2_C_RHA cd18791
C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A ...
837-994 2.84e-67

C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family members are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350178 [Multi-domain]  Cd Length: 171  Bit Score: 223.95  E-value: 2.84e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362  837 ILYMNPHKINLDLILELLAYLDKSpqfrNIEGAVLIFLPGLAHIQQLYDLL-SNDRRFYSERYKVIALHSILSTQDQAAA 915
Cdd:cd18791   17 ISSEKEDPDYVDAAVRLILQIHRT----EEPGDILVFLPGQEEIERLCELLrEELLSPDLGKLLVLPLHSSLPPEEQQRV 92
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 67782362  916 FTLPPPGVRKIVLATNIAETGITIPDVVFVIDTGRTKENKYHESSQMSSLVETFVSKASALQRQGRAGRVRDGFCFRMY 994
Cdd:cd18791   93 FEPPPPGVRKVVLATNIAETSITIPGVVYVIDSGLVKEKVYDPRTGLSSLVTVWISKASAEQRAGRAGRTRPGKCYRLY 171
DEXHc_DHX36 cd17981
DEXH-box helicase domain of DEAH-box helicase 36; DEAH-box helicase 36 (DHX36, also known as ...
572-754 1.12e-66

DEXH-box helicase domain of DEAH-box helicase 36; DEAH-box helicase 36 (DHX36, also known as G4-resolvase 1 or G4R1, MLE-like protein 1 and RNA helicase associated with AU-rich element or RHAU) unwinds a G4-quadruplex in human telomerase RNA. DHX36 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350739 [Multi-domain]  Cd Length: 180  Bit Score: 222.80  E-value: 1.12e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362  572 LPVFKHRDSIVETLKRHRVVVVAGETGSGKSTQVPHFLLEDLLLnEWEASKCNIVCTQPRRISAVSLANRVCDELgCENG 651
Cdd:cd17981    1 LPSYGMKQEIINMIDNNQVTVISGETGCGKTTQVTQFILDDAIE-RGKGSSCRIVCTQPRRISAISVAERVAAER-AESC 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362  652 PGGRNSlcGYQIRMESR-ACESTRLLYCTTGVLLRKLQEDGLLSNVSHVIVDEVHERSVQSDFLLIILKEILQKRSDLHL 730
Cdd:cd17981   79 GLGNST--GYQIRLESRkPRKQGSILYCTTGIVLQWLQSDPHLSNVSHLVLDEIHERNLQSDVLMGIVKDLLPFRSDLKV 156
                        170       180
                 ....*....|....*....|....
gi 67782362  731 ILMSATVDSEKFSTYFTHCPILRI 754
Cdd:cd17981  157 ILMSATLNAEKFSDYFNNCPMIHI 180
DEXHc_DHX9 cd17972
DEXH-box helicase domain of DEAH-box helicase 9; DEAH-box helicase 9 (DHX9, also known as ...
520-754 8.76e-66

DEXH-box helicase domain of DEAH-box helicase 9; DEAH-box helicase 9 (DHX9, also known as ATP-dependent RNA helicase A or RHA and leukophysin or LKP) plays an important role in many cellular processes, including regulation of DNA replication, transcription, translation, microRNA biogenesis, RNA processing and transport, and maintenance of genomic stability. DHX9 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350730 [Multi-domain]  Cd Length: 234  Bit Score: 222.40  E-value: 8.76e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362  520 PEESWENLVSDE-DFSALSLESANVEDLEPVRNLFRKLQSTPKYQKLLKERQQLPVFKHRDSIVETLKRHRVVVVAGETG 598
Cdd:cd17972    6 PQSNWNPWTSSNiDEGPLAFATPEQISMDLKNELMYQREQDHNLQQILQERELLPVKKFREEILEAISNNPVVIIRGATG 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362  599 SGKSTQVPHFLLEDLLLNEwEASKCNIVCTQPRRISAVSLANRVCDELGCENGPGgrnslCGYQIRMES---RACEStrL 675
Cdd:cd17972   86 CGKTTQVPQYILDDFIQND-RAAECNIVVTQPRRISAVSVAERVAFERGEEVGKS-----CGYSVRFESvlpRPHAS--I 157
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 67782362  676 LYCTTGVLLRKLqEDGLlSNVSHVIVDEVHERSVQSDFLLIILKEILQKRSDLHLILMSATVDSEKFSTYFTHCPILRI 754
Cdd:cd17972  158 LFCTVGVLLRKL-EAGI-RGISHVIVDEIHERDINTDFLLVVLRDVVQAYPDLRVILMSATIDTSMFCEYFFNCPVIEV 234
PRK11664 PRK11664
ATP-dependent RNA helicase HrpB; Provisional
571-1110 3.10e-65

ATP-dependent RNA helicase HrpB; Provisional


Pssm-ID: 236950 [Multi-domain]  Cd Length: 812  Bit Score: 238.29  E-value: 3.10e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362   571 QLPVFKHRDSIVETLKRHRVVVVAGETGSGKSTQVPhflLEDLLLNEWEAskcNIVCTQPRRISAVSLANRVCDELGCEn 650
Cdd:PRK11664    3 SLPVAAVLPELLTALKTAPQVLLKAPTGAGKSTWLP---LQLLQHGGING---KIIMLEPRRLAARNVAQRLAEQLGEK- 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362   651 gPGGRnslCGYQIRMESRACESTRLLYCTTGVLLRKLQEDGLLSNVSHVIVDEVHERSVQSDFLLIILKEILQK-RSDLH 729
Cdd:PRK11664   76 -PGET---VGYRMRAESKVGPNTRLEVVTEGILTRMIQRDPELSGVGLVILDEFHERSLQADLALALLLDVQQGlRDDLK 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362   730 LILMSATVDSEKFSTYFTHCPILRISGRSYPVEvfhlediieetgfvlekdseycqkfleeeeevtinvtskaggikkyQ 809
Cdd:PRK11664  152 LLIMSATLDNDRLQQLLPDAPVIVSEGRSFPVE----------------------------------------------R 185
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362   810 EYIPVqtGAHadlNPFYQKYSSRtqhailymnphkinldlILELLayldkspqfRNIEGAVLIFLPGLAHIQQLYDLLSN 889
Cdd:PRK11664  186 RYQPL--PAH---QRFDEAVARA-----------------TAELL---------RQESGSLLLFLPGVGEIQRVQEQLAS 234
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362   890 DrrfYSERYKVIALHSILSTQDQAAAFTLPPPGVRKIVLATNIAETGITIPDVVFVIDTGRTKENKYHESSQMSSLVETF 969
Cdd:PRK11664  235 R---VASDVLLCPLYGALSLAEQQKAILPAPAGRRKVVLATNIAETSLTIEGIRLVVDSGLERVARFDPKTGLTRLVTQR 311
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362   970 VSKASALQRQGRAGRVRDGFCFRMYTRERFEGFMDYSVPEILRVPLEELCLHIMKCNLGSPEDFlsKALDPPQLQVISNA 1049
Cdd:PRK11664  312 ISQASMTQRAGRAGRLEPGICLHLYSKEQAERAAAQSEPEILHSDLSGLLLELLQWGCHDPAQL--SWLDQPPAAALAAA 389
                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 67782362  1050 MNLLRKIGACElNEPKLTPLGQHLAALPVNVKIGKMLIFGAIFG-CLDPVATLAAVMTEKSP 1110
Cdd:PRK11664  390 KRLLQQLGALD-GQGRLTARGRKMAALGNDPRLAAMLVAAKEDDeAALATAAKLAAILEEPP 450
DEXHc_DHX57 cd17985
DEXH-box helicase domain of DEAH-box helicase 57; DEAH-box helicase 57 (DHX57) belongs to the ...
572-754 3.80e-65

DEXH-box helicase domain of DEAH-box helicase 57; DEAH-box helicase 57 (DHX57) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350743 [Multi-domain]  Cd Length: 177  Bit Score: 218.17  E-value: 3.80e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362  572 LPVFKHRDSIVETLKRHRVVVVAGETGSGKSTQVPHFLLEDLLLNEWEASkCNIVCTQPRRISAVSLANRVCDELGCENG 651
Cdd:cd17985    1 LPAWQERETILELLEKHQVLVISGMTGCGKTTQIPQFILDNSLQGPPLPV-ANIICTQPRRISAISVAERVAQERAERVG 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362  652 pggrnSLCGYQIRMESRACESTRLLYCTTGVLLRKLQEDGLLSNVSHVIVDEVHERSVQSDFLLIILKEILQKRSDLHLI 731
Cdd:cd17985   80 -----QSVGYQIRLESVKSSATRLLYCTTGVLLRRLEGDPTLQGVTHVIVDEVHERTEESDFLLLVLKDLMVQRPDLKVI 154
                        170       180
                 ....*....|....*....|...
gi 67782362  732 LMSATVDSEKFSTYFTHCPILRI 754
Cdd:cd17985  155 LMSATLNAELFSDYFNSCPVIHI 177
DEXHc_YTHDC2 cd17987
DEXH-box helicase domain of YTH domain containing 2; YTH domain containing 2 (YTHDC2) ...
572-754 9.40e-59

DEXH-box helicase domain of YTH domain containing 2; YTH domain containing 2 (YTHDC2) regulates mRNA translation and stability via binding to N6-methyladenosine, a modified RNA nucleotide enriched in the stop codons and 3' UTRs of eukaryotic messenger RNAs. YTHDC2 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350745 [Multi-domain]  Cd Length: 176  Bit Score: 200.06  E-value: 9.40e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362  572 LPVFKHRDSIVETLKRHRVVVVAGETGSGKSTQVPHFLLEDLLLNeweASKCNIVCTQPRRISAVSLANRVCDELGCENG 651
Cdd:cd17987    1 LPVFEKQEQIVRIIKENKVVLIVGETGSGKTTQIPQFLLDDCYAN---GIPCRIFCTQPRRLAAIAVAERVAAERGEKIG 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362  652 pggrnSLCGYQIRMESRACESTRLLYCTTGVLLRKLQE-DGLLSNVSHVIVDEVHERSVQSDFLLIILKEILQKRSDLHL 730
Cdd:cd17987   78 -----QTVGYQIRLESRVSPKTLLTFCTNGVLLRTLMAgDSALSTVTHVIVDEVHERDRFSDFLLTKLRDILQKHPNLKL 152
                        170       180
                 ....*....|....*....|....
gi 67782362  731 ILMSATVDSEKFSTYFTHCPILRI 754
Cdd:cd17987  153 ILSSAALDVNLFIRYFGSCPVIYI 176
DEXHc_DHX15 cd17973
DEXH-box helicase domain of DEAH-box helicase 15; DEAH-box helicase 15 (DHX15) is a pre-mRNA ...
560-754 3.02e-57

DEXH-box helicase domain of DEAH-box helicase 15; DEAH-box helicase 15 (DHX15) is a pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA. DHX15 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 438709 [Multi-domain]  Cd Length: 187  Bit Score: 196.10  E-value: 3.02e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362  560 PKYQKLLKERQQLPVFKHRDSIVETLKRHRVVVVAGETGSGKSTQVPHFLLEDLLLnewEASKCNIVCTQPRRISAVSLA 639
Cdd:cd17973    1 QRYFEILEKRRELPVWEQKEDFLKLLKNNQILVLVGETGSGKTTQIPQFVLDDELP---HQPKKLVACTQPRRVAAMSVA 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362  640 NRVCDELGCENGpggrnSLCGYQIRMESRACESTRLLYCTTGVLLRKLQEDGLLSNVSHVIVDEVHERSVQSDFLLIILK 719
Cdd:cd17973   78 QRVAEEMDVKLG-----EEVGYSIRFEDCSSAKTILKYMTDGMLLREAMSDPLLSRYSVIILDEAHERTLATDILMGLLK 152
                        170       180       190
                 ....*....|....*....|....*....|....*
gi 67782362  720 EILQKRSDLHLILMSATVDSEKFSTYFTHCPILRI 754
Cdd:cd17973  153 EVVRRRPDLKLIVMSATLDAGKFQKYFDNAPLLKV 187
DEXHc_DHX34 cd17979
DEXH-box helicase domain of DEAH-box helicase 34; DEAH-box helicase 34 (DHX34) plays a role in ...
572-754 1.34e-55

DEXH-box helicase domain of DEAH-box helicase 34; DEAH-box helicase 34 (DHX34) plays a role in the nonsense-mediated decay (NMD), a surveillance mechanism that degrades aberrant mRNAs. DHX34 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350737 [Multi-domain]  Cd Length: 170  Bit Score: 190.73  E-value: 1.34e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362  572 LPVFKHRDSIVETLKRHRVVVVAGETGSGKSTQVPHFLLEdlllneweASKCNIVCTQPRRISAVSLANRVCDELGCENG 651
Cdd:cd17979    1 LPIAQYREKIIELLKTHQVVIVAGDTGCGKSTQVPQYLLA--------AGFRHIACTQPRRIACISLAKRVAFESLNQYG 72
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362  652 pggrnSLCGYQIRMESRACESTRLLYCTTGVLLRKLQEDGLLSNVSHVIVDEVHERSVQSDFLLIILKEILQKRSDLHLI 731
Cdd:cd17979   73 -----SKVAYQIRFERTRTLATKLLFLTEGLLLRQIQRDASLPQYNVLILDEVHERHLHGDFLLGVLRCLLRLRPDLKLI 147
                        170       180
                 ....*....|....*....|...
gi 67782362  732 LMSATVDSEKFSTYFTHCPILRI 754
Cdd:cd17979  148 LMSATINIELFSGYFEGAPVVQV 170
DEXHc_DHX33 cd17978
DEXH-box helicase domain of DEAH-box helicase 33; DEAH-box helicase 33 (DHX33) stimulates RNA ...
572-754 7.98e-53

DEXH-box helicase domain of DEAH-box helicase 33; DEAH-box helicase 33 (DHX33) stimulates RNA polymerase I transcription of the 47S precursor rRNA. DHX33 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 438710 [Multi-domain]  Cd Length: 178  Bit Score: 182.94  E-value: 7.98e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362  572 LPVFKHRDSIVETLKRHRVVVVAGETGSGKSTQVPHFLLEDlllneWEASKCNIVCTQPRRISAVSLANRVCDELGCENG 651
Cdd:cd17978    1 LPIYSARKRLLEELRKHDTVIIIGETGSGKTTQIPQYLYEA-----GFARGGMIGITQPRRVAAVSVAKRVAEEMGVELG 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362  652 pggrnSLCGYQIRMESRACESTRLLYCTTGVLLRKLQEDGLLSNVSHVIVDEVHERSVQSDFLLIILKEILQKR-----S 726
Cdd:cd17978   76 -----QLVGYSVRFDDVTSEETRIKYMTDGMLLREAIGDPLLSKYSVIILDEAHERTVHTDVLFGLVKSAQRRRkeqklS 150
                        170       180
                 ....*....|....*....|....*...
gi 67782362  727 DLHLILMSATVDSEKFSTYFTHCPILRI 754
Cdd:cd17978  151 PLKVIIMSATLDADLFSEYFNGAPVLYI 178
DEXHc_TDRD9 cd17988
DEXH-box helicase domain of tudor domain containing 9; Tudor domain containing 9 (TDRD9, also ...
572-747 2.50e-51

DEXH-box helicase domain of tudor domain containing 9; Tudor domain containing 9 (TDRD9, also known as HIG-1or NET54 or C14orf75) is a part of the nuclear PIWI-interacting RNA (piRNA) pathway essential for transposon silencing and male fertility TDRD9 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350746 [Multi-domain]  Cd Length: 180  Bit Score: 178.85  E-value: 2.50e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362  572 LPVFKHRDSIVETLKRHRVVVVAGETGSGKSTQVPHFLLEDLLlnewEASK-CNIVCTQPRRISAVSLANRVCDELGCEN 650
Cdd:cd17988    1 LPIYAKREEILSLIEANSVVIIKGATGCGKTTQLPQFILDHYY----KRGKyCNIVVTQPRRIAAISIARRVSQEREWTL 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362  651 GpggrnSLCGYQIRMESRACESTRLLYCTTGVLLRKLQEDGLLSNVSHVIVDEVHERSVQSDFLLIILKEILQKRSD-LH 729
Cdd:cd17988   77 G-----SLVGYQVGLERPASEETRLIYCTTGVLLQKLINNKTLTEYTHIILDEVHERDQELDFLLLVVRRLLRTNSRhVK 151
                        170
                 ....*....|....*...
gi 67782362  730 LILMSATVDSEKFSTYFT 747
Cdd:cd17988  152 IILMSATISCKEFADYFT 169
DEXHc_DHX35 cd17980
DEXH-box helicase domain of DEAH-box helicase 35; DHX35 plays a role in colorectal cancers and ...
572-746 2.04e-50

DEXH-box helicase domain of DEAH-box helicase 35; DHX35 plays a role in colorectal cancers and seems to be associated with risk to thyroid cancers. It also has been shown to positively regulate poxviruses, such as Myxoma virus. DEAH-box helicase 35 (DHX35) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350738 [Multi-domain]  Cd Length: 185  Bit Score: 176.51  E-value: 2.04e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362  572 LPVFKHRDSIVETLKRHRVVVVAGETGSGKSTQVPHFLLEdlllNEWEASKCNIVCTQPRRISAVSLANRVCDELGCENG 651
Cdd:cd17980    1 LPVFKLRNHILYLVENYQTIVIVGETGCGKSTQIPQYLAE----AGWTAGGRVVGCTQPRRVAAVTVAGRVAEEMGAVLG 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362  652 pggrnSLCGYQIRMESRACE-STRLLYCTTGVLLRKLQEDGLLSNVSHVIVDEVHERSVQSDFLLIILKEILQKRSDLHL 730
Cdd:cd17980   77 -----HEVGYCIRFDDCTDPqATRIKFLTDGMLVREMMLDPLLTKYSVIMLDEAHERTLYTDILIGLLKKIQKKRGDLRL 151
                        170
                 ....*....|....*.
gi 67782362  731 ILMSATVDSEKFSTYF 746
Cdd:cd17980  152 IVASATLDAEKFRDFF 167
DEXHc_DHX8 cd17971
DEXH-box helicase domain of DEAH-box helicase 8; DEAH-box helicase 8 (DHX8 ,also known as ...
568-754 6.53e-50

DEXH-box helicase domain of DEAH-box helicase 8; DEAH-box helicase 8 (DHX8 ,also known as pre-mRNA-splicing factor ATP-dependent RNA helicase PRP22) acts late in the splicing of pre-mRNA and mediates the release of the spliced mRNA from spliceosomes. DHX8 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350729 [Multi-domain]  Cd Length: 179  Bit Score: 174.59  E-value: 6.53e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362  568 ERQQLPVFKHRDSIVETLKRHRVVVVAGETGSGKSTQVPHFLLEdlllnEWEASKCNIVCTQPRRISAVSLANRVCDELG 647
Cdd:cd17971    2 QRESLPIYKLKEQLIQAVHDNQILVVIGETGSGKTTQITQYLAE-----AGYTSRGKIGCTQPRRVAAMSVAKRVAEEFG 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362  648 CENGpggrnSLCGYQIRMESRACESTRLLYCTTGVLLRKLQEDGLLSNVSHVIVDEVHERSVQSDFLLIILKEILQKRSD 727
Cdd:cd17971   77 CCLG-----QEVGYTIRFEDCTSPETVIKYMTDGMLLRECLIDPDLSQYSVIMLDEAHERTIHTDVLFGLLKKTVQKRPD 151
                        170       180
                 ....*....|....*....|....*..
gi 67782362  728 LHLILMSATVDSEKFSTYFTHCPILRI 754
Cdd:cd17971  152 LKLIVTSATLDAVKFSQYFYEAPIFTI 178
DEXHc_DHX38 cd17983
DEXH-box helicase domain of DEAH-box helicase 38; DEAH-box helicase 38 (DHX38, also known as ...
572-754 4.73e-49

DEXH-box helicase domain of DEAH-box helicase 38; DEAH-box helicase 38 (DHX38, also known as PRP16) is involved in pre-mRNA splicing. DHX38 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350741 [Multi-domain]  Cd Length: 173  Bit Score: 171.88  E-value: 4.73e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362  572 LPVFKHRDSIVETLKRHRVVVVAGETGSGKSTQVPHFLLEDLLlneweASKCNIVCTQPRRISAVSLANRVCDELGCENG 651
Cdd:cd17983    1 LPIFAVRQELLNVIRDNNVVIVVGETGSGKTTQLTQYLHEDGY-----TDYGMIGCTQPRRVAAMSVAKRVSEEMGVELG 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362  652 pggrnSLCGYQIRMESRACESTRLLYCTTGVLLRKLQEDGLLSNVSHVIVDEVHERSVQSDFLLIILKEILQKRSDLHLI 731
Cdd:cd17983   76 -----EEVGYAIRFEDCTSENTVIKYMTDGILLRESLRDPDLDKYSAIIMDEAHERSLNTDVLFGLLREVVARRRDLKLI 150
                        170       180
                 ....*....|....*....|...
gi 67782362  732 LMSATVDSEKFSTYFTHCPILRI 754
Cdd:cd17983  151 VTSATMDADKFADFFGNVPIFTI 173
DEXHc_DHX16 cd17974
DEXH-box helicase domain of DEAH-box helicase 16; DEAH-box helicase 16 (DHX16) is probably ...
572-754 4.89e-48

DEXH-box helicase domain of DEAH-box helicase 16; DEAH-box helicase 16 (DHX16) is probably involved in pre-mRNA splicing. DHX16 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350732 [Multi-domain]  Cd Length: 174  Bit Score: 169.22  E-value: 4.89e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362  572 LPVFKHRDSIVETLKRHRVVVVAGETGSGKSTQVPHFLLEDlllnEWEASKCNIVCTQPRRISAVSLANRVCDELGCENG 651
Cdd:cd17974    1 LPVYPYRDDLLAAVKEHQVLIIVGETGSGKTTQIPQYLHEA----GYTKGGGKIGCTQPRRVAAMSVAARVAEEMGVKLG 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362  652 pggrnSLCGYQIRMESRACESTRLLYCTTGVLLRKLQEDGLLSNVSHVIVDEVHERSVQSDFLLIILKEILQKRSDLHLI 731
Cdd:cd17974   77 -----NEVGYSIRFEDCTSEKTVLKYMTDGMLLREFLTEPDLASYSVMIIDEAHERTLHTDILFGLVKDIARFRPDLKLL 151
                        170       180
                 ....*....|....*....|...
gi 67782362  732 LMSATVDSEKFSTYFTHCPILRI 754
Cdd:cd17974  152 ISSATMDAEKFSAFFDDAPIFRI 174
DEXHc_HrpA cd17989
DEXH-box helicase domain of ATP-dependent RNA helicase HrpA; HrpA is part of the HrpB-HrpA ...
572-754 2.09e-47

DEXH-box helicase domain of ATP-dependent RNA helicase HrpA; HrpA is part of the HrpB-HrpA two-partner secretion (TPS) system, a secretion pathway important to the secretion of large virulence-associated proteins. HrpA belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350747 [Multi-domain]  Cd Length: 173  Bit Score: 167.25  E-value: 2.09e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362  572 LPVFKHRDSIVETLKRHRVVVVAGETGSGKSTQVPHFLLEDLLlneweASKCNIVCTQPRRISAVSLANRVCDELGCENG 651
Cdd:cd17989    1 LPVSQKRDEIAKAIAENQVVIIAGETGSGKTTQLPKICLELGR-----GIRGLIGHTQPRRLAARSVAERIAEELKTELG 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362  652 pggrnSLCGYQIRMESRACESTRLLYCTTGVLLRKLQEDGLLSNVSHVIVDEVHERSVQSDFLLIILKEILQKRSDLHLI 731
Cdd:cd17989   76 -----GAVGYKVRFTDQTSDETCVKLMTDGILLAETQTDRYLRAYDTIIIDEAHERSLNIDFLLGYLKQLLPRRPDLKVI 150
                        170       180
                 ....*....|....*....|...
gi 67782362  732 LMSATVDSEKFSTYFTHCPILRI 754
Cdd:cd17989  151 ITSATIDAERFSRHFNNAPIIEV 173
DEXHc_DHX37 cd17982
DEXH-box helicase domain of DEAH-box helicase 37; DHX37 plays a role in the development of the ...
572-743 2.17e-46

DEXH-box helicase domain of DEAH-box helicase 37; DHX37 plays a role in the development of the human nervous system and has been linked to schizophrenia. It also negatively regulates poxviruses such as Myxoma virus. DEAH-box helicase 37 (DHX37) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350740 [Multi-domain]  Cd Length: 191  Bit Score: 165.22  E-value: 2.17e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362  572 LPVFKHRDSIVETLKRHRVVVVAGETGSGKSTQVPHFLLEDLLLNEWEASKCNIVCTQPRRISAVSLANRVCDELgceNG 651
Cdd:cd17982    1 LPILAEEQEIMEAINENPVVIICGETGSGKTTQVPQFLYEAGFGSPESDNPGMIGITQPRRVAAVSMAKRVAEEL---NV 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362  652 PGGRnslCGYQIRMESRACESTRLLYCTTGVLLRKLQEDGLLSNVSHVIVDEVHERSVQSDFLLIILKEILQKRSDLH-- 729
Cdd:cd17982   78 FGKE---VSYQIRYDSTVSENTKIKFMTDGVLLKEIQTDFLLRKYSVIIIDEAHERSVNTDILIGMLSRIVPLRAKLYlq 154
                        170       180
                 ....*....|....*....|..
gi 67782362  730 --------LILMSATVDSEKFS 743
Cdd:cd17982  155 dqtvkplkLVIMSATLRVEDFT 176
DEXHc_DHX40 cd17984
DEXH-box helicase domain of DEAH-box helicase 40; DEAH-box helicase 40 (DHX40) belongs to the ...
572-754 4.87e-41

DEXH-box helicase domain of DEAH-box helicase 40; DEAH-box helicase 40 (DHX40) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350742 [Multi-domain]  Cd Length: 178  Bit Score: 149.23  E-value: 4.87e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362  572 LPVFKHRDSIVETLKRHRVVVVAGETGSGKSTQVPHFLLEDLLlneweASKCNIVCTQPRRISAVSLANRVCDELGCENG 651
Cdd:cd17984    1 LPIQKQRKKLVQAVRDNSFLIVTGNTGSGKTTQLPKYLYEAGF-----SQHGMIGVTQPRRVAAISVAQRVAEEMKCTLG 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362  652 pggrnSLCGYQIRMESRACESTRLLYCTTGVLLRKLQEDGLLSNVSHVIVDEVHERSVQSDFLLIILKEILQKRS----- 726
Cdd:cd17984   76 -----SKVGYQVRFDDCSSKETAIKYMTDGCLLRHILADPNLTKYSVIILDEAHERSLTTDILFGLLKKLFQEKSpnrke 150
                        170       180
                 ....*....|....*....|....*...
gi 67782362  727 DLHLILMSATVDSEKFSTYFTHCPILRI 754
Cdd:cd17984  151 HLKVVVMSATLELAKLSAFFGNCPVFDI 178
DEXHc_HrpB cd17990
DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA ...
572-753 1.23e-40

DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA two-partner secretion (TPS) system, a secretion pathway important to the secretion of large virulence-associated proteins. HrpB belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 438711 [Multi-domain]  Cd Length: 174  Bit Score: 147.86  E-value: 1.23e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362  572 LPVFKHRDSIVETLKRHRVVVVAGETGSGKSTQVPHFLLEDLLLnewEASKcnIVCTQPRRISAVSLANRVCDELGCEng 651
Cdd:cd17990    1 LPIAAVLPALRAALDAGGQVVLEAPPGAGKTTRVPLALLAELWI---AGGK--IIVLEPRRVAARAAARRLATLLGEA-- 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362  652 PGGRnslCGYQIRMESRACESTRLLYCTTGVLLRKLQEDGLLSNVSHVIVDEVHERSVQSDFLLIILKEILQ-KRSDLHL 730
Cdd:cd17990   74 PGET---VGYRVRGESRVGRRTRVEVVTEGVLLRRLQRDPELSGVGAVILDEFHERSLDADLALALLLEVQQlLRDDLRL 150
                        170       180
                 ....*....|....*....|...
gi 67782362  731 ILMSATVDSEKFSTYFTHCPILR 753
Cdd:cd17990  151 LAMSATLDGDGLAALLPEAPVVE 173
DEXHc_DHX32 cd17977
DEXH-box helicase domain of DEAH-box helicase 32; DEAH-box helicase 32 (DHX32) belongs to the ...
572-754 1.54e-31

DEXH-box helicase domain of DEAH-box helicase 32; DEAH-box helicase 32 (DHX32) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350735 [Multi-domain]  Cd Length: 176  Bit Score: 121.86  E-value: 1.54e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362  572 LPVFKHRDSIVETLKRHRVVVVAGETGSGKSTQVPHFLLEDLLLNEWEASKcnIVCTQPRRISAVSLANRVCDELGCENG 651
Cdd:cd17977    1 LPVWEAKYEFMESLAHNQIVIVSGDAKTGKSSQIPQWCAEYCLSAHYQHGV--VVCTQVHKQTAVWLALRVADEMDVNIG 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362  652 pggrnSLCGYQIRMESRACESTRLLYCTTGVLLRKLQEDGLLSNVSHVIVDEVHERSVQSDFLLIILKEILQKRSDLHLI 731
Cdd:cd17977   79 -----HEVGYVIPFENCCTNETILRYCTDDMLLREMMSDPLLESYGVIILDDAHERTVSTDVLLGLLKDVLLSRPELKLV 153
                        170       180
                 ....*....|....*....|...
gi 67782362  732 LMSATVDSEKFSTYFTHCPILRI 754
Cdd:cd17977  154 IITCPHLSSKLLSYYGNVPLIEV 176
DEXQc_DQX1 cd17986
DEXQ-box helicase domain of DEAQ-box RNA dependent ATPase 1; DEAQ-box RNA dependent ATPase 1 ...
572-754 7.45e-25

DEXQ-box helicase domain of DEAQ-box RNA dependent ATPase 1; DEAQ-box RNA dependent ATPase 1 (DQX1) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350744 [Multi-domain]  Cd Length: 177  Bit Score: 102.67  E-value: 7.45e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362  572 LPVFKHRDSIVETLKRHR-VVVVAGETGSGKSTQVPHFLLEDLLLNEWeaSKCNIVCTQPRRISAVSLANRVCDE----L 646
Cdd:cd17986    1 LPIWAAKFTFLEQLESPSgIVLVSGEPGSGKSTQVPQWCAEFALSRGF--QKGQVTVTQPHPLAARSLALRVADEmdlnL 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362  647 GCEngpggrnslCGYQIRMESRACESTRLLYCTTGVLLRKLQEDGLLSNVSHVIVDEVHERSVQSDFLLIILKEILQKRS 726
Cdd:cd17986   79 GHE---------VGYSIPQEDCTGPNTILRFCWDRLLLQEMTSTPLLGAWGVVVLDEAQERSVASDSLLGLLKDVRLQRP 149
                        170       180
                 ....*....|....*....|....*...
gi 67782362  727 DLHLILMSATVDSEKFSTYFTHCPILRI 754
Cdd:cd17986  150 ELRVVVVTSPALEPKLRAFWGNPPVVHV 177
DEXDc smart00487
DEAD-like helicases superfamily;
578-764 1.24e-24

DEAD-like helicases superfamily;


Pssm-ID: 214692 [Multi-domain]  Cd Length: 201  Bit Score: 102.96  E-value: 1.24e-24
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362     578 RDSIVETLKRHRVVVVAGETGSGKSTQVPHFLLEDLLlnewEASKCNIVCTQPRRisavSLANRVCDELGCENGPGGRNS 657
Cdd:smart00487   14 KEAIEALLSGLRDVILAAPTGSGKTLAALLPALEALK----RGKGGRVLVLVPTR----ELAEQWAEELKKLGPSLGLKV 85
                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362     658 LC---GYQIRMESRACES--TRLLYCTTGVLLRKLQEDGL-LSNVSHVIVDEVHERSVQsDFLLIILKEILQKRSDLHLI 731
Cdd:smart00487   86 VGlygGDSKREQLRKLESgkTDILVTTPGRLLDLLENDKLsLSNVDLVILDEAHRLLDG-GFGDQLEKLLKLLPKNVQLL 164
                           170       180       190
                    ....*....|....*....|....*....|....*..
gi 67782362     732 LMSAT--VDSEKFSTYFTHCP--ILRISGRSYPVEVF 764
Cdd:smart00487  165 LLSATppEEIENLLELFLNDPvfIDVGFTPLEPIEQF 201
HA2 pfam04408
Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in ...
1049-1138 8.46e-21

Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.


Pssm-ID: 461295 [Multi-domain]  Cd Length: 104  Bit Score: 88.45  E-value: 8.46e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362   1049 AMNLLRKIGAceLNE-PKLTPLGQHLAALPVNVKIGKMLIFGAIFGCLDPVATLAAVMTEKSPFTTPIG----------- 1116
Cdd:pfam04408    1 ALELLYYLGA--LDEdGELTPLGRKMAELPLDPRLAKMLLAAAELGCLDEVLTIVAALSVRDPFVQPNFldprsaakaar 78
                           90       100
                   ....*....|....*....|....*.
gi 67782362   1117 ----RKDEADLAKSALAMADSDHLTI 1138
Cdd:pfam04408   79 rrrrAADEKARAKFARLDLEGDHLTL 104
HA2 smart00847
Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino ...
1056-1137 1.89e-20

Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.


Pssm-ID: 214852 [Multi-domain]  Cd Length: 82  Bit Score: 86.94  E-value: 1.89e-20
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362    1056 IGACELNEpKLTPLGQHLAALPVNVKIGKMLIFGAIFGCLDPVATLAAVMTEKSPFttPIGRKDEADLAKSALAMADSDH 1135
Cdd:smart00847    2 LGALDDDG-RLTPLGRKMAELPLDPRLAKMLLAAAEFGCLDEILTIVAMLSVGDPR--PKEKREDADAARRRFADPESDH 78

                    ..
gi 67782362    1136 LT 1137
Cdd:smart00847   79 LT 80
OB_NTP_bind pfam07717
Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus ...
1216-1302 2.22e-16

Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus of the DEAD-box helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. There do seem to be a couple of instances where it occurs by itself -. The structure PDB:3i4u adopts an OB-fold. helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. This C-terminal domain of the yeast helicase contains an oligonucleotide/oligosaccharide-binding (OB)-fold which seems to be placed at the entrance of the putative nucleic acid cavity. It also constitutes the binding site for the G-patch-containing domain of Pfa1p. When found on DEAH/RHA helicases, this domain is central to the regulation of the helicase activity through its binding of both RNA and G-patch domain proteins.


Pssm-ID: 400182 [Multi-domain]  Cd Length: 82  Bit Score: 75.37  E-value: 2.22e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362   1216 LKAVLVAGLYDNVGKIIYTKSVDVTEKLacivetaQGKAQVHPSSVNRDLQTH--GWLLYQEKIRYARVYLRETTLITPF 1293
Cdd:pfam07717    1 LRAALAAGLYPNVARRDPKGKGYTTLSD-------NQRVFIHPSSVLFNEKTFppEWVVYQELVETTKVYIRTVTAISPE 73

                   ....*....
gi 67782362   1294 PVLLFGGDI 1302
Cdd:pfam07717   74 WLLLFAPHI 82
HELICc smart00490
helicase superfamily c-terminal domain;
881-984 2.65e-14

helicase superfamily c-terminal domain;


Pssm-ID: 197757 [Multi-domain]  Cd Length: 82  Bit Score: 69.16  E-value: 2.65e-14
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362     881 QQLYDLLSNdrrfysERYKVIALHSILSTQDQAAAFTLPPPGVRKIVLATNIAETGITIPDVVFVIDTGrtkenkyhess 960
Cdd:smart00490    1 EELAELLKE------LGIKVARLHGGLSQEEREEILDKFNNGKIKVLVATDVAERGLDLPGVDLVIIYD----------- 63
                            90       100
                    ....*....|....*....|....
gi 67782362     961 qmsslveTFVSKASALQRQGRAGR 984
Cdd:smart00490   64 -------LPWSPASYIQRIGRAGR 80
SF2-N cd00046
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ...
591-736 8.25e-14

N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.


Pssm-ID: 350668 [Multi-domain]  Cd Length: 146  Bit Score: 70.12  E-value: 8.25e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362  591 VVVAGETGSGKSTQVPHFLLEDLLLNEweaskCNIVCTQPRRISAVSLANRVCDELGcengpggRNSLCGYQIRMESrAC 670
Cdd:cd00046    4 VLITAPTGSGKTLAALLAALLLLLKKG-----KKVLVLVPTKALALQTAERLRELFG-------PGIRVAVLVGGSS-AE 70
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 67782362  671 ESTR-------LLYCTTGVLLRKLQEDGLL--SNVSHVIVDEVHERSVQSDFLLII-LKEILQKRSDLHLILMSAT 736
Cdd:cd00046   71 EREKnklgdadIIIATPDMLLNLLLREDRLflKDLKLIIVDEAHALLIDSRGALILdLAVRKAGLKNAQVILLSAT 146
DEAD pfam00270
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ...
580-740 6.14e-13

DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.


Pssm-ID: 425570 [Multi-domain]  Cd Length: 165  Bit Score: 68.04  E-value: 6.14e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362    580 SIVETLKRHRVVVVAGETGSGKST--QVPhflLEDLLLNEWEASKCNIVCtqPRRisavSLAN---RVCDELGCENGPGG 654
Cdd:pfam00270    6 EAIPAILEGRDVLVQAPTGSGKTLafLLP---ALEALDKLDNGPQALVLA--PTR----ELAEqiyEELKKLGKGLGLKV 76
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362    655 RNSLCGYQIRMESRACESTRLLYCTTGVLLRKLQEDGLLSNVSHVIVDEVHeRSVQSDFLLIILKEILQKRSDLHLILMS 734
Cdd:pfam00270   77 ASLLGGDSRKEQLEKLKGPDILVGTPGRLLDLLQERKLLKNLKLLVLDEAH-RLLDMGFGPDLEEILRRLPKKRQILLLS 155

                   ....*.
gi 67782362    735 ATVDSE 740
Cdd:pfam00270  156 ATLPRN 161
Helicase_C pfam00271
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ...
847-985 3.56e-11

Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.


Pssm-ID: 459740 [Multi-domain]  Cd Length: 109  Bit Score: 61.46  E-value: 3.56e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362    847 LDLILELLAyldkspqfRNIEGAVLIFLPGLAHIQqlYDLLSNdrrfySERYKVIALHSILSTQDQAAAFTLPPPGVRKI 926
Cdd:pfam00271    3 LEALLELLK--------KERGGKVLIFSQTKKTLE--AELLLE-----KEGIKVARLHGDLSQEEREEILEDFRKGKIDV 67
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 67782362    927 VLATNIAETGITIPDVVFVIDTGRTKenkyhessqmsslvetfvSKASALQRQGRAGRV 985
Cdd:pfam00271   68 LVATDVAERGLDLPDVDLVINYDLPW------------------NPASYIQRIGRAGRA 108
PHA02653 PHA02653
RNA helicase NPH-II; Provisional
581-1055 1.99e-10

RNA helicase NPH-II; Provisional


Pssm-ID: 177443 [Multi-domain]  Cd Length: 675  Bit Score: 65.38  E-value: 1.99e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362   581 IVETLKRHRVVVVAGETGSGKSTQVPHFLL---------EDLLLNEWEASKCNIVCTQPRRISAVSLANRVCDELGCENG 651
Cdd:PHA02653  172 IFEAWISRKPVVLTGGTGVGKTSQVPKLLLwfnylfggfDNLDKIDPNFIERPIVLSLPRVALVRLHSITLLKSLGFDEI 251
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362   652 PGGRNSLCGYQIRMESR--ACESTRLLYCTTGVLLRKLqedgllSNVSHVIVDEVHERSVQSDFLLIIL-KEILQKRSdl 728
Cdd:PHA02653  252 DGSPISLKYGSIPDELIntNPKPYGLVFSTHKLTLNKL------FDYGTVIIDEVHEHDQIGDIIIAVArKHIDKIRS-- 323
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362   729 hLILMSATvdsekfstyfthcpilrisgrsypvevfhlediieetgfvLEKDSEYCQKFLEEEEEVtinvtskaggikky 808
Cdd:PHA02653  324 -LFLMTAT----------------------------------------LEDDRDRIKEFFPNPAFV-------------- 348
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362   809 qeYIPVQTgahadLNPF---YQKYSSRTQHAILYMNPHKINLDLILELLAYLDKSpqfrniegAVLIFLPGLAHIQQLYD 885
Cdd:PHA02653  349 --HIPGGT-----LFPIsevYVKNKYNPKNKRAYIEEEKKNIVTALKKYTPPKGS--------SGIVFVASVSQCEEYKK 413
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362   886 LLSNdrrfYSERYKVIALHSILSTQDQAAAFTLPPPGVrKIVLATNIAETGITIPDVVFVIDTGRTKENKYHESSQMssl 965
Cdd:PHA02653  414 YLEK----RLPIYDFYIIHGKVPNIDEILEKVYSSKNP-SIIISTPYLESSVTIRNATHVYDTGRVYVPEPFGGKEM--- 485
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362   966 vetFVSKASALQRQGRAGRVRDGFCFRMYTrerfegfMDYSVPeILRVPLEELCLHIM---KCNLGSPEDFLskaldppq 1042
Cdd:PHA02653  486 ---FISKSMRTQRKGRVGRVSPGTYVYFYD-------LDLLKP-IKRIDSEFLHNYILyakYFNLTLPEDLF-------- 546
                         490
                  ....*....|...
gi 67782362  1043 lqVISNAMNLLRK 1055
Cdd:PHA02653  547 --VIPSNLDRLRK 557
SSL2 COG1061
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
510-942 2.84e-08

Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];


Pssm-ID: 440681 [Multi-domain]  Cd Length: 566  Bit Score: 58.11  E-value: 2.84e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362  510 SENKRENSEDPEESWENLVSDEDFSALSLESANVEDLEPVRNLFRKLQSTPKYQKLLKERQQLPVFKHR---------DS 580
Cdd:COG1061   12 DKLRSSLLLLDLERLELSLLRNLVEARRLAIKEGTREDGRRLPEEDTERELAEAEALEAGDEASGTSFElrpyqqealEA 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362  581 IVETLKRH--RVVVVAGeTGSGKSTqvphFLLEDLllnEWEASKCNIVCTQPRRISAVSLANRVCDELGCENGPGGRNSl 658
Cdd:COG1061   92 LLAALERGggRGLVVAP-TGTGKTV----LALALA---AELLRGKRVLVLVPRRELLEQWAEELRRFLGDPLAGGGKKD- 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362  659 cgyqirmesracESTRLLYCTTGVLLRKLQEDGLLSNVSHVIVDEVHERSVQSdflliiLKEILQKRSDLHLILMSATvd 738
Cdd:COG1061  163 ------------SDAPITVATYQSLARRAHLDELGDRFGLVIIDEAHHAGAPS------YRRILEAFPAAYRLGLTAT-- 222
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362  739 sekfstyfthcPIlRISGRsyPVEVFHLEDIIEETGfvlekdseycqkfLEEEEEvtinvtskAGGIKKYqEYIPVqtga 818
Cdd:COG1061  223 -----------PF-RSDGR--EILLFLFDGIVYEYS-------------LKEAIE--------DGYLAPP-EYYGI---- 262
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362  819 HADLNPFYQKYSSRTQHAILYMNPHKINLDLILEllAYLDKSPQFRniegAVLIFLPGLAHIQQLYDLLSndrrfySERY 898
Cdd:COG1061  263 RVDLTDERAEYDALSERLREALAADAERKDKILR--ELLREHPDDR----KTLVFCSSVDHAEALAELLN------EAGI 330
                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*..
gi 67782362  899 KVIALHSILSTQDQA---AAFTLpppGVRKIVLATNIAETGITIPDV 942
Cdd:COG1061  331 RAAVVTGDTPKKEREeilEAFRD---GELRILVTVDVLNEGVDVPRL 374
DEXHc_Ski2 cd17921
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases ...
571-754 2.91e-06

DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350679 [Multi-domain]  Cd Length: 181  Bit Score: 49.18  E-value: 2.91e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362  571 QLPVFKHRDsivetLKRHRVVVVAGeTGSGKStqvphFLLEDLLLNEWEASKCNIVCTQPRRisavSLANRVCDELGCEN 650
Cdd:cd17921    6 QREALRALY-----LSGDSVLVSAP-TSSGKT-----LIAELAILRALATSGGKAVYIAPTR----ALVNQKEADLRERF 70
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362  651 GPGGRN-SLCGYQIRMESRACESTRLLYCTT---GVLLRKLQEDgLLSNVSHVIVDEVH--ERSVQSDFLLIILKEILQK 724
Cdd:cd17921   71 GPLGKNvGLLTGDPSVNKLLLAEADILVATPeklDLLLRNGGER-LIQDVRLVVVDEAHliGDGERGVVLELLLSRLLRI 149
                        170       180       190
                 ....*....|....*....|....*....|.
gi 67782362  725 RSDLHLILMSATVDS-EKFSTYFTHCPILRI 754
Cdd:cd17921  150 NKNARFVGLSATLPNaEDLAEWLGVEDLIRF 180
SF2_C cd18785
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ...
925-984 1.46e-04

C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350172 [Multi-domain]  Cd Length: 77  Bit Score: 41.54  E-value: 1.46e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362  925 KIVLATNIAETGITIPDVVFVIDTGRTKenkyhessqmsslvetfvSKASALQRQGRAGR 984
Cdd:cd18785   24 EILVATNVLGEGIDVPSLDTVIFFDPPS------------------SAASYIQRVGRAGR 65
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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