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Conserved domains on  [gi|9506867|ref|NP_062330|]
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dynein axonemal assembly factor 11 [Mus musculus]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 1903219)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PPP1R42 super family cl42388
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 23-161 4.91e-20

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


The actual alignment was detected with superfamily member cd21340:

Pssm-ID: 455733 [Multi-domain]  Cd Length: 220  Bit Score: 88.30  E-value: 4.91e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9506867   23 LEELSLHQQEIERLEHIDKwCRDLKILYLQNNLIGKIENVSKLKKLE------------------------------YLN 72
Cdd:cd21340  48 LTHLYLQNNQIEKIENLEN-LVNLKKLYLGGNRISVVEGLENLTNLEelhienqrlppgekltfdprslaalsnslrVLN 126

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9506867   73 LALNNIERIENLEGCEWLTKLDLTVNFIGELSSVK-TLTHNIHLKELFLMGNPCADFDGYRQFVVVTLQQLKWLDGKEIE 151
Cdd:cd21340 127 ISGNNIDSLEPLAPLRNLEQLDASNNQISDLEELLdLLSSWPSLRELDLTGNPVCKKPKYRDKIILASKSLEVLDGKEIT 206

                       170
                ....*....|
gi 9506867  152 RSERiQALQN 161
Cdd:cd21340 207 DTER-QFLKR 215
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 23-161 4.91e-20

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 88.30  E-value: 4.91e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9506867   23 LEELSLHQQEIERLEHIDKwCRDLKILYLQNNLIGKIENVSKLKKLE------------------------------YLN 72
Cdd:cd21340  48 LTHLYLQNNQIEKIENLEN-LVNLKKLYLGGNRISVVEGLENLTNLEelhienqrlppgekltfdprslaalsnslrVLN 126

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9506867   73 LALNNIERIENLEGCEWLTKLDLTVNFIGELSSVK-TLTHNIHLKELFLMGNPCADFDGYRQFVVVTLQQLKWLDGKEIE 151
Cdd:cd21340 127 ISGNNIDSLEPLAPLRNLEQLDASNNQISDLEELLdLLSSWPSLRELDLTGNPVCKKPKYRDKIILASKSLEVLDGKEIT 206

                       170
                ....*....|
gi 9506867  152 RSERiQALQN 161
Cdd:cd21340 207 DTER-QFLKR 215
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
22-241 1.59e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 66.11  E-value: 1.59e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9506867   22 SLEELSLHQQEIERLEHIDKWCRDLKILYLQNNLIGKI-ENVSKLKKLEYLNLALNNIERIENLEGCEWLTKLDLTVNFI 100
Cdd:COG4886 183 NLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLpEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQL 262

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9506867  101 GELSSVKTLThniHLKELFLMGNPCADFDGYRQFVVVTLQQLKWLDGKEIERSERIQALQNYTSVEQQIREQEKAYCLRR 180
Cdd:COG4886 263 TDLPPLANLT---NLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTT 339

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 9506867  181 AKEKEEAQRKLEEENESEDKKKSSTGFDGHWYTDIHTACPSATENQDYPQVPETQEEQHNT 241
Cdd:COG4886 340 LALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGV 400
LRR_9 pfam14580
Leucine-rich repeat;
1-164 9.03e-10

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 57.85  E-value: 9.03e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9506867      1 MGRITEDLIRRNAEHNDCVifSLEELSLHQQEIERLEHIDKWCRDLKILYLQNNLIGKIENVSKLKKLEYLNLALNNIER 80
Cdd:pfam14580   1 MVKLTAELIEQSAQYTNPV--RERELDLRGYKIPIIENLGATLDQFDTIDFSDNEIRKLDGFPLLRRLKTLLLNNNRICR 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9506867     81 I-ENL-EGCEWLTKLDLTVNFIGELSSVKTLTHNIHLKELFLMGNPCADFDGYRQFVVVTLQQLKWLDGKEIERSERIQA 158
Cdd:pfam14580  79 IgEGLgEALPNLTELILTNNNLQELGDLDPLASLKKLTFLSLLRNPVTNKPHYRLYVIYKVPQLRLLDFRKVKQKERQAA 158


                  ....*.
gi 9506867    159 LQNYTS 164
Cdd:pfam14580 159 EKMFRS 164
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 23-161 4.91e-20

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 88.30  E-value: 4.91e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9506867   23 LEELSLHQQEIERLEHIDKwCRDLKILYLQNNLIGKIENVSKLKKLE------------------------------YLN 72
Cdd:cd21340  48 LTHLYLQNNQIEKIENLEN-LVNLKKLYLGGNRISVVEGLENLTNLEelhienqrlppgekltfdprslaalsnslrVLN 126

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9506867   73 LALNNIERIENLEGCEWLTKLDLTVNFIGELSSVK-TLTHNIHLKELFLMGNPCADFDGYRQFVVVTLQQLKWLDGKEIE 151
Cdd:cd21340 127 ISGNNIDSLEPLAPLRNLEQLDASNNQISDLEELLdLLSSWPSLRELDLTGNPVCKKPKYRDKIILASKSLEVLDGKEIT 206

                       170
                ....*....|
gi 9506867  152 RSERiQALQN 161
Cdd:cd21340 207 DTER-QFLKR 215
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
22-241 1.59e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 66.11  E-value: 1.59e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9506867   22 SLEELSLHQQEIERLEHIDKWCRDLKILYLQNNLIGKI-ENVSKLKKLEYLNLALNNIERIENLEGCEWLTKLDLTVNFI 100
Cdd:COG4886 183 NLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLpEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQL 262

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9506867  101 GELSSVKTLThniHLKELFLMGNPCADFDGYRQFVVVTLQQLKWLDGKEIERSERIQALQNYTSVEQQIREQEKAYCLRR 180
Cdd:COG4886 263 TDLPPLANLT---NLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTT 339

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 9506867  181 AKEKEEAQRKLEEENESEDKKKSSTGFDGHWYTDIHTACPSATENQDYPQVPETQEEQHNT 241
Cdd:COG4886 340 LALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGV 400
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
22-146 4.26e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 64.57  E-value: 4.26e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9506867   22 SLEELSLHQQEIERL-EHIDKwCRDLKILYLQNNLIGKI-ENVSKLKKLEYLNLALNNIERI-ENLEGCEWLTKLDLTVN 98
Cdd:COG4886 114 NLESLDLSGNQLTDLpEELAN-LTNLKELDLSNNQLTDLpEPLGNLTNLKSLDLSNNQLTDLpEELGNLTNLKELDLSNN 192

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 9506867   99 FIGELSsvKTLTHNIHLKELFLMGNPCADFDGyrqfVVVTLQQLKWLD 146
Cdd:COG4886 193 QITDLP--EPLGNLTNLEELDLSGNQLTDLPE----PLANLTNLETLD 234
LRR_9 pfam14580
Leucine-rich repeat;
1-164 9.03e-10

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 57.85  E-value: 9.03e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9506867      1 MGRITEDLIRRNAEHNDCVifSLEELSLHQQEIERLEHIDKWCRDLKILYLQNNLIGKIENVSKLKKLEYLNLALNNIER 80
Cdd:pfam14580   1 MVKLTAELIEQSAQYTNPV--RERELDLRGYKIPIIENLGATLDQFDTIDFSDNEIRKLDGFPLLRRLKTLLLNNNRICR 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9506867     81 I-ENL-EGCEWLTKLDLTVNFIGELSSVKTLTHNIHLKELFLMGNPCADFDGYRQFVVVTLQQLKWLDGKEIERSERIQA 158
Cdd:pfam14580  79 IgEGLgEALPNLTELILTNNNLQELGDLDPLASLKKLTFLSLLRNPVTNKPHYRLYVIYKVPQLRLLDFRKVKQKERQAA 158


                  ....*.
gi 9506867    159 LQNYTS 164
Cdd:pfam14580 159 EKMFRS 164
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 46-86 1.57e-06

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 44.93  E-value: 1.57e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 9506867     46 LKILYLQNNLIGKIENVSKLKKLEYLNLALNN-IERIENLEG 86
Cdd:pfam12799   3 LEVLDLSNNQITDIPPLAKLPNLETLDLSGNNkITDLSDLAN 44
LRR_8 pfam13855
Leucine rich repeat;
46-98 3.12e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.44  E-value: 3.12e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 9506867     46 LKILYLQNNLIGKIENVS--KLKKLEYLNLALNNIERIEN--LEGCEWLTKLDLTVN 98
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAfkGLSNLKVLDLSNNLLTTLSPgaFSGLPSLRYLDLSGN 59
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
46-146 7.10e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 44.92  E-value: 7.10e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9506867   46 LKILYLQNNligkiENVSKLKKLEYLNLALNNIERI-ENLEGCEWLTKLDLTVNFIGELSSVktLTHNIHLKELFLMGNP 124
Cdd:COG4886  98 LTELDLSGN-----EELSNLTNLESLDLSGNQLTDLpEELANLTNLKELDLSNNQLTDLPEP--LGNLTNLKSLDLSNNQ 170

                        90       100
                ....*....|....*....|..
gi 9506867  125 CADFDGyrqfVVVTLQQLKWLD 146
Cdd:COG4886 171 LTDLPE----ELGNLTNLKELD 188
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 66-107 4.73e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 37.61  E-value: 4.73e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 9506867     66 KKLEYLNLALNNIERIENLEGCEWLTKLDLT-VNFIGELSSVK 107
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPLAKLPNLETLDLSgNNKITDLSDLA 43
LRR_8 pfam13855
Leucine rich repeat;
22-78 1.07e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.12  E-value: 1.07e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 9506867     22 SLEELSLHQQEIERLEhiDKW---CRDLKILYLQNNLIGKIENVS--KLKKLEYLNLALNNI 78
Cdd:pfam13855   2 NLRSLDLSNNRLTSLD--DGAfkgLSNLKVLDLSNNLLTTLSPGAfsGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
23-146 2.02e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 40.30  E-value: 2.02e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9506867   23 LEELSLHQQEIERLEHIDKWCRDLKILYLQNNLIGKIENVSKLKKLEYLNLALNNierieNLEGCEWLTKLDLTVNFIGE 102
Cdd:COG4886  53 LSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-----ELSNLTNLESLDLSGNQLTD 127

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 9506867  103 LSsvKTLTHNIHLKELFLMGNPCADFDgyrqFVVVTLQQLKWLD 146
Cdd:COG4886 128 LP--EELANLTNLKELDLSNNQLTDLP----EPLGNLTNLKSLD 165
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 46-127 2.16e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 40.54  E-value: 2.16e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9506867   46 LKILYLQNNLIGK------IENVSKLKKLEYLNLALNNI------ERIENLEGCEWLTKLDLTVNFIGELSSV---KTLT 110
Cdd:COG5238 210 VTTLWLKRNPIGDegaeilAEALKGNKSLTTLDLSNNQIgdegviALAEALKNNTTVETLYLSGNQIGAEGAIalaKALQ 289

                        90
                ....*....|....*..
gi 9506867  111 HNIHLKELFLMGNPCAD 127
Cdd:COG5238 290 GNTTLTSLDLSVNRIGD 306
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 49-127 3.25e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 39.77  E-value: 3.25e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9506867   49 LYLQNNLIGK------IENVSKLKKLEYLNLALNNI------ERIENLEGCEWLTKLDLTVNFIGE---LSSVKTLTHNI 113
Cdd:COG5238 269 LYLSGNQIGAegaialAKALQGNTTLTSLDLSVNRIgdegaiALAEGLQGNKTLHTLNLAYNGIGAqgaIALAKALQENT 348

                        90
                ....*....|....
gi 9506867  114 HLKELFLMGNPCAD 127
Cdd:COG5238 349 TLHSLDLSDNQIGD 362
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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