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Conserved domains on  [gi|20149304|ref|NP_065752|]
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pre-mRNA-splicing factor ISY1 homolog isoform 2 [Homo sapiens]

Protein Classification

pre-mRNA-splicing factor ISY1( domain architecture ID 10533340)

pre-mRNA-splicing factor ISY1 is involved in pre-mRNA splicing and cell cycle control

Gene Ontology:  GO:0071020|GO:0000389

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Isy1 pfam06246
Isy1-like splicing family; Isy1 protein is important in the optimization of splicing.
1-266 2.46e-125

Isy1-like splicing family; Isy1 protein is important in the optimization of splicing.


:

Pssm-ID: 461860  Cd Length: 247  Bit Score: 356.90  E-value: 2.46e-125
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20149304     1 MARNAEKAMTALARFRQAQLEEGKVKE---RRPFLASECTELPKAEKWRRQIIGEISKKVAQIQNAGLGEFRIRDLNDEI 77
Cdd:pfam06246   1 MARNEEKAQSMLNRFREAKAAELGLLEsngRRPKLASECTSLPEAEKWRRQVLREISRKVTKIQDAGLGEYQIRDLNDEI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20149304    78 NKLLREKGHWEVRIKELGGPDYGKVGPKMLDHEGKEVPGNRGYKYFGAAKDLPGVRELFEKEPLP--PPRKTRAELMKAI 155
Cdd:pfam06246  81 NKLLREKRHWERRIKELGGPDYRRGGPKMLDAEGREIPGGRGYRYFGRAKELPGVKELFEKEAPEeeKPRKTRAELYKNI 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20149304   156 DFEYYGYLDEDDGVIVPLEQEYEKKLRAELVEKWKAEREarlargekeeeeeeeeeiniyavtEEESDEEGSQEKGGDDS 235
Cdd:pfam06246 161 DADYYGYRDEEDGVLLEYEAEAEKEAREEAVWKEEKKLE------------------------EEEEGEEEWESDPSDAG 216
                         250       260       270
                  ....*....|....*....|....*....|.
gi 20149304   236 QQKFIAHVPVPSQQEIEEALVRRKKMELLQK 266
Cdd:pfam06246 217 DGSFIAHVPLPTQEEIEQWLLERRKQELLEK 247
 
Name Accession Description Interval E-value
Isy1 pfam06246
Isy1-like splicing family; Isy1 protein is important in the optimization of splicing.
1-266 2.46e-125

Isy1-like splicing family; Isy1 protein is important in the optimization of splicing.


Pssm-ID: 461860  Cd Length: 247  Bit Score: 356.90  E-value: 2.46e-125
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20149304     1 MARNAEKAMTALARFRQAQLEEGKVKE---RRPFLASECTELPKAEKWRRQIIGEISKKVAQIQNAGLGEFRIRDLNDEI 77
Cdd:pfam06246   1 MARNEEKAQSMLNRFREAKAAELGLLEsngRRPKLASECTSLPEAEKWRRQVLREISRKVTKIQDAGLGEYQIRDLNDEI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20149304    78 NKLLREKGHWEVRIKELGGPDYGKVGPKMLDHEGKEVPGNRGYKYFGAAKDLPGVRELFEKEPLP--PPRKTRAELMKAI 155
Cdd:pfam06246  81 NKLLREKRHWERRIKELGGPDYRRGGPKMLDAEGREIPGGRGYRYFGRAKELPGVKELFEKEAPEeeKPRKTRAELYKNI 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20149304   156 DFEYYGYLDEDDGVIVPLEQEYEKKLRAELVEKWKAEREarlargekeeeeeeeeeiniyavtEEESDEEGSQEKGGDDS 235
Cdd:pfam06246 161 DADYYGYRDEEDGVLLEYEAEAEKEAREEAVWKEEKKLE------------------------EEEEGEEEWESDPSDAG 216
                         250       260       270
                  ....*....|....*....|....*....|.
gi 20149304   236 QQKFIAHVPVPSQQEIEEALVRRKKMELLQK 266
Cdd:pfam06246 217 DGSFIAHVPLPTQEEIEQWLLERRKQELLEK 247
 
Name Accession Description Interval E-value
Isy1 pfam06246
Isy1-like splicing family; Isy1 protein is important in the optimization of splicing.
1-266 2.46e-125

Isy1-like splicing family; Isy1 protein is important in the optimization of splicing.


Pssm-ID: 461860  Cd Length: 247  Bit Score: 356.90  E-value: 2.46e-125
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20149304     1 MARNAEKAMTALARFRQAQLEEGKVKE---RRPFLASECTELPKAEKWRRQIIGEISKKVAQIQNAGLGEFRIRDLNDEI 77
Cdd:pfam06246   1 MARNEEKAQSMLNRFREAKAAELGLLEsngRRPKLASECTSLPEAEKWRRQVLREISRKVTKIQDAGLGEYQIRDLNDEI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20149304    78 NKLLREKGHWEVRIKELGGPDYGKVGPKMLDHEGKEVPGNRGYKYFGAAKDLPGVRELFEKEPLP--PPRKTRAELMKAI 155
Cdd:pfam06246  81 NKLLREKRHWERRIKELGGPDYRRGGPKMLDAEGREIPGGRGYRYFGRAKELPGVKELFEKEAPEeeKPRKTRAELYKNI 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20149304   156 DFEYYGYLDEDDGVIVPLEQEYEKKLRAELVEKWKAEREarlargekeeeeeeeeeiniyavtEEESDEEGSQEKGGDDS 235
Cdd:pfam06246 161 DADYYGYRDEEDGVLLEYEAEAEKEAREEAVWKEEKKLE------------------------EEEEGEEEWESDPSDAG 216
                         250       260       270
                  ....*....|....*....|....*....|.
gi 20149304   236 QQKFIAHVPVPSQQEIEEALVRRKKMELLQK 266
Cdd:pfam06246 217 DGSFIAHVPLPTQEEIEQWLLERRKQELLEK 247
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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