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Conserved domains on  [gi|10834942|ref|NP_066903|]
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transcriptional regulator ICP4 [Gallid alphaherpesvirus 3]

Protein Classification

protein kinase family protein; Mps1 family protein kinase( domain architecture ID 11476204)

protein kinase family protein, may catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine and/or tyrosine residues on protein substrates| Mps1 family protein kinase may be a dual-specificity kinase that catalyzes the transfer of the gamma-phosphoryl group from ATP to serine/threonine as well as tyrosine residues on protein substrates

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 873-1992 0e+00

transcriptional regulator ICP4; Provisional


:

Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 918.79  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10834942   873 WNGPSPRPGLVSSPTGTQERYRRVQPGSGSDGSHTTAPPAVLKQALQQEVGTPATRASHPLPRPPPASYPSLGCRSRSSS 952
Cdd:PHA03307  275 WNGPSSRPGPASSSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRESSSSSTSSSSESSRGAAVSPGPSPSRSPSPS 354

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10834942   953 SSSASSSSSSSSSAPSSSEQSSAAPSSRTSSRSptrEAGAPQCAARGRGRGRGGRRGRGRRAPSP------SSETAAPPP 1026
Cdd:PHA03307  355 RPPPPADPSSPRKRPRPSRAPSSPAASAGRPTR---RRARAAVAGRARRRDATGRFPAGRPRPSPldagaaSGAFYARYP 431

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10834942  1027 PDDLDQEVWWQIPSPPAGRCWFGPLGGHRQALRGIPEVEQAAVRFLSTPGPLPVYVEEMGNCAKQYEALVSAMLNKDVKA 1106
Cdd:PHA03307  432 LLTPSGEPWPGSPPPPPGRVRYGGLGDSRPGLWDAPEVREAAARYEASPGPVPVYVPEMGDSAKQYAALVRLLYTPDREA 511

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10834942  1107 NPlnWAHHGKLSPTDAALNHIYVTKFRsSHSSPGAAVTGTVNKCIPHIASAMKKRNLLWALPHIAASVSMTRRYCKDQKE 1186
Cdd:PHA03307  512 MG--WLQNPKLTGPDQALDQFCQKKFQ-APRGSGSFITGSVARPVPHIGDAMAAGNALWALPHAAAAVAMSRRYDRAQKG 588

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10834942  1187 FMFRSLRKAYAPMASAASAEMRRpsaspisnrapvtaqstaaglipvidvstihdrvrrgvaafnsaleeglldVPEYRL 1266
Cdd:PHA03307  589 FLLQSLRRAYAPMAYPENAADTG---------------------------------------------------AGAAAP 617

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10834942  1267 VAPARPDIPAGDGFASTRPLNELVDACALECEGVVAALLRGPDGPGAvaemlssCEDGPFPRPAGH-EQWEKCRALLGSW 1345
Cdd:PHA03307  618 APAAPRPDAAAAGGASARPLRELADACVLACRAVLEALLEGPDGLSA-------VPGLAFPRPACPpRALEACPARLESW 690

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10834942  1346 LRDLLDLRSAVYAAYANG--SAPRGRQERTLAANAAALITEAIGPLLSKDPARPWRCPGSRDITSVLLRECGSRG----- 1418
Cdd:PHA03307  691 LRELRDLRDAVYLARLRGdlPVAGGREERVAAVRAVSLVARTVAPLVRYSPRRARARASAWDITDALFSNPSLVPaklae 770

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10834942  1419 -----------------EPVRSREKARRLQRVARLLADADAASSGTSEGRSR---------SAEPCYDPGPASSPEPVRa 1472
Cdd:PHA03307  771 alallepaepqrgagssPPVRAEAAFRRPGRLRRSGPAADAASRTASKRKSRshtpdggseSSGPARPPGAAARPPPAR- 849

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10834942  1473 lcaqtSAESRKRKSAPAAVLDGADNAVENPRPRLGRSRTGAGPPPVASCTRPPTPPEACRDAGPFPPKrprcfpwrdpar 1552
Cdd:PHA03307  850 -----SSESSKSKPAAAGGRARGKNGRRRPRPPEPRARPGAAAPPKAAAAAPPAGAPAPRPRPAPRVK------------ 912

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10834942  1553 imDGSLSLGDRRHRGaAFRKPPIGTPIAGYAGPPHLDAYCPGEGVDELTSFAQIPTLWRQPLARSPEAMAEIARVASTPS 1632
Cdd:PHA03307  913 --LGPMPPGGPDPRG-GFRRVPPGDLHTPAPSAAALAAYCPPEVVAELVDHPLFPEPWRPALAFDPEALAEIAARCGGPP 989

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10834942  1633 HVSRSPdtaasegVLCRTAVVSLRARTAWMRhQQASPEDVALVILYTANPGEHLFCVPAPGSPPGGPRFDPNRGGLSFLL 1712
Cdd:PHA03307  990 PRSGSA-------FGPLRASGPLRRRAAWMR-QIPDPEDVRVVVLYSPLPGEHLFGVPAPDASPGGPAWSPERGGLSFLL 1061

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10834942  1713 AALANRLCLPESAAWAGRWRAAPDVSALTAAGVMFLSPQDLGFAGVLEHLQRLCLKREKRLVVLDTLEDRDRPENGPRlV 1792
Cdd:PHA03307 1062 AALGNRLCLPDSHAWAGNWTGAPDVSALNAQGVLLLSTRDLAFAGAVEYLCLRLGSARRRLIVLDTVDPEDWPADGPA-V 1140

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10834942  1793 EEAVRYVRCTVSPRSQCSVRWPGHPDLATTVITSRDVLGPVVLRELETHFRRENPAAGDISLCCGSNVRYKVATRLDRVA 1872
Cdd:PHA03307 1141 SQYHVYLRCAVLPRAQCAVRWPAARDLARAVLTSSRVFGPGLFARVEAAFARLYPDAPPLRLCRGANVRYTVRTRLGPRT 1220

                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10834942  1873 TVPMTALSYLAASSALVAGR---------QRPPGPDFLAGESHSHRAALKWGLYAPLRPVYVLEPKKNAIVSPDFLNRTV 1943
Cdd:PHA03307 1221 RVPLPPREYRQAVLPALDGCkdmaaqaegLGLGAPDFLEGEAHSHRAANRWGLGAPLRPVYLAEGRRAAIAGPDELPAVV 1300

                        1130      1140      1150      1160
                  ....*....|....*....|....*....|....*....|....*....
gi 10834942  1944 CDVCRSVVLPPDPHAQPVVVHVpeatcSLLAREMlaHLRSSSVVWLEGD 1992
Cdd:PHA03307 1301 RAFCRAALLEPDPEAPPLVLPP-----SAAAEAA--HARAPRVTWAKSE 1342
PHA03307 super family cl33723
transcriptional regulator ICP4; Provisional
 1-418 1.30e-11

transcriptional regulator ICP4; Provisional


The actual alignment was detected with superfamily member PHA03307:

Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 70.20  E-value: 1.30e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10834942     1 MENPPDFYSLLEMLADNGGFSPQPPATPGDPyqdvclntpsvavpptpgrqpvpprsksparaapvagslagarapfgie 80
Cdd:PHA03307    1 SDNAPDLYDLIEAAAEGGEFFPRPPATPGDA------------------------------------------------- 31

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10834942    81 gavsegsdtglrsaepPDGAHQGSPGEVVSSTADIVDVCGNETAAAAPRSCSWQKTvgdlvpagsergEPSPMDPRKSND 160
Cdd:PHA03307   32 ----------------ADDLLSGSQGQLVSDSAELAAVTVVAGAAACDRFEPPTGP------------PPGPGTEAPANE 83

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10834942   161 PvrcvsdapckptgactplavcvetlpppsgvppppppepIVNFPWTFSPLTPGPFAQHHSPTPPTPPPLSPPPPTPPPL 240
Cdd:PHA03307   84 S---------------------------------------RSTPTWSLSTLAPASPAREGSPTPPGPSSPDPPPPTPPPA 124

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10834942   241 SPPPPTPPPLSPPPPTPPPHTPPPHGSPPPTPLPSTSPPSTQTSSPSASLPLDSPPASTPPPPTPLHDRPLSPDPPALSA 320
Cdd:PHA03307  125 SPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQAALPLSSPEETARAPSSPPAEPPPSTPPAAASP 204

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10834942   321 SCQRPSPPLSPSAPRLAPAPLRSDRVPARRKSSVSEGGGPRTRGAGFQYVCRLSASARIPSPPREELELVARQPGSHAML 400
Cdd:PHA03307  205 RPPRRSSPISASASSPAPAPGRSAADDAGASSSDSSSSESSGCGWGPENECPLPRPAPITLPTRIWEASGWNGPSSRPGP 284

                         410       420
                  ....*....|....*....|..
gi 10834942   401 WR----AGARDGATEPSSGDDP 418
Cdd:PHA03307  285 ASssssPRERSPSPSPSSPGSG 306
PHA03307 super family cl33723
transcriptional regulator ICP4; Provisional
 408-581 4.58e-05

transcriptional regulator ICP4; Provisional


The actual alignment was detected with superfamily member PHA03307:

Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 48.63  E-value: 4.58e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10834942   408 GATEPSSGDDPKVFLLALSDARRCPSYWDRLAREAVLREILPTPRGSPLRTSPGSIELpreAPLLDSDYRPFEWRCAKGR 487
Cdd:PHA03307  118 PPTPPPASPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQAALP---LSSPEETARAPSSPPAEPP 194

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10834942   488 PLPQEPVFPCPPNELGNDWAACKMWLFSRCARlvlSTLDDMSPSEDGESVLESQGCGWGPQNECPLPLPAPIVLPTRIWE 567
Cdd:PHA03307  195 PSTPPAAASPRPPRRSSPISASASSPAPAPGR---SAADDAGASSSDSSSSESSGCGWGPENECPLPRPAPITLPTRIWE 271

                         170
                  ....*....|....
gi 10834942   568 AVTRLPRPAPRTPT 581
Cdd:PHA03307  272 ASGWNGPSSRPGPA 285
 
Name Accession Description Interval E-value
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 873-1992 0e+00

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 918.79  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10834942   873 WNGPSPRPGLVSSPTGTQERYRRVQPGSGSDGSHTTAPPAVLKQALQQEVGTPATRASHPLPRPPPASYPSLGCRSRSSS 952
Cdd:PHA03307  275 WNGPSSRPGPASSSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRESSSSSTSSSSESSRGAAVSPGPSPSRSPSPS 354

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10834942   953 SSSASSSSSSSSSAPSSSEQSSAAPSSRTSSRSptrEAGAPQCAARGRGRGRGGRRGRGRRAPSP------SSETAAPPP 1026
Cdd:PHA03307  355 RPPPPADPSSPRKRPRPSRAPSSPAASAGRPTR---RRARAAVAGRARRRDATGRFPAGRPRPSPldagaaSGAFYARYP 431

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10834942  1027 PDDLDQEVWWQIPSPPAGRCWFGPLGGHRQALRGIPEVEQAAVRFLSTPGPLPVYVEEMGNCAKQYEALVSAMLNKDVKA 1106
Cdd:PHA03307  432 LLTPSGEPWPGSPPPPPGRVRYGGLGDSRPGLWDAPEVREAAARYEASPGPVPVYVPEMGDSAKQYAALVRLLYTPDREA 511

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10834942  1107 NPlnWAHHGKLSPTDAALNHIYVTKFRsSHSSPGAAVTGTVNKCIPHIASAMKKRNLLWALPHIAASVSMTRRYCKDQKE 1186
Cdd:PHA03307  512 MG--WLQNPKLTGPDQALDQFCQKKFQ-APRGSGSFITGSVARPVPHIGDAMAAGNALWALPHAAAAVAMSRRYDRAQKG 588

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10834942  1187 FMFRSLRKAYAPMASAASAEMRRpsaspisnrapvtaqstaaglipvidvstihdrvrrgvaafnsaleeglldVPEYRL 1266
Cdd:PHA03307  589 FLLQSLRRAYAPMAYPENAADTG---------------------------------------------------AGAAAP 617

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10834942  1267 VAPARPDIPAGDGFASTRPLNELVDACALECEGVVAALLRGPDGPGAvaemlssCEDGPFPRPAGH-EQWEKCRALLGSW 1345
Cdd:PHA03307  618 APAAPRPDAAAAGGASARPLRELADACVLACRAVLEALLEGPDGLSA-------VPGLAFPRPACPpRALEACPARLESW 690

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10834942  1346 LRDLLDLRSAVYAAYANG--SAPRGRQERTLAANAAALITEAIGPLLSKDPARPWRCPGSRDITSVLLRECGSRG----- 1418
Cdd:PHA03307  691 LRELRDLRDAVYLARLRGdlPVAGGREERVAAVRAVSLVARTVAPLVRYSPRRARARASAWDITDALFSNPSLVPaklae 770

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10834942  1419 -----------------EPVRSREKARRLQRVARLLADADAASSGTSEGRSR---------SAEPCYDPGPASSPEPVRa 1472
Cdd:PHA03307  771 alallepaepqrgagssPPVRAEAAFRRPGRLRRSGPAADAASRTASKRKSRshtpdggseSSGPARPPGAAARPPPAR- 849

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10834942  1473 lcaqtSAESRKRKSAPAAVLDGADNAVENPRPRLGRSRTGAGPPPVASCTRPPTPPEACRDAGPFPPKrprcfpwrdpar 1552
Cdd:PHA03307  850 -----SSESSKSKPAAAGGRARGKNGRRRPRPPEPRARPGAAAPPKAAAAAPPAGAPAPRPRPAPRVK------------ 912

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10834942  1553 imDGSLSLGDRRHRGaAFRKPPIGTPIAGYAGPPHLDAYCPGEGVDELTSFAQIPTLWRQPLARSPEAMAEIARVASTPS 1632
Cdd:PHA03307  913 --LGPMPPGGPDPRG-GFRRVPPGDLHTPAPSAAALAAYCPPEVVAELVDHPLFPEPWRPALAFDPEALAEIAARCGGPP 989

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10834942  1633 HVSRSPdtaasegVLCRTAVVSLRARTAWMRhQQASPEDVALVILYTANPGEHLFCVPAPGSPPGGPRFDPNRGGLSFLL 1712
Cdd:PHA03307  990 PRSGSA-------FGPLRASGPLRRRAAWMR-QIPDPEDVRVVVLYSPLPGEHLFGVPAPDASPGGPAWSPERGGLSFLL 1061

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10834942  1713 AALANRLCLPESAAWAGRWRAAPDVSALTAAGVMFLSPQDLGFAGVLEHLQRLCLKREKRLVVLDTLEDRDRPENGPRlV 1792
Cdd:PHA03307 1062 AALGNRLCLPDSHAWAGNWTGAPDVSALNAQGVLLLSTRDLAFAGAVEYLCLRLGSARRRLIVLDTVDPEDWPADGPA-V 1140

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10834942  1793 EEAVRYVRCTVSPRSQCSVRWPGHPDLATTVITSRDVLGPVVLRELETHFRRENPAAGDISLCCGSNVRYKVATRLDRVA 1872
Cdd:PHA03307 1141 SQYHVYLRCAVLPRAQCAVRWPAARDLARAVLTSSRVFGPGLFARVEAAFARLYPDAPPLRLCRGANVRYTVRTRLGPRT 1220

                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10834942  1873 TVPMTALSYLAASSALVAGR---------QRPPGPDFLAGESHSHRAALKWGLYAPLRPVYVLEPKKNAIVSPDFLNRTV 1943
Cdd:PHA03307 1221 RVPLPPREYRQAVLPALDGCkdmaaqaegLGLGAPDFLEGEAHSHRAANRWGLGAPLRPVYLAEGRRAAIAGPDELPAVV 1300

                        1130      1140      1150      1160
                  ....*....|....*....|....*....|....*....|....*....
gi 10834942  1944 CDVCRSVVLPPDPHAQPVVVHVpeatcSLLAREMlaHLRSSSVVWLEGD 1992
Cdd:PHA03307 1301 RAFCRAALLEPDPEAPPLVLPP-----SAAAEAA--HARAPRVTWAKSE 1342
Herpes_ICP4_C pfam03585
Herpesvirus ICP4-like protein C-terminal region; The immediate-early protein ICP4 ...
 1568-1993 2.14e-113

Herpesvirus ICP4-like protein C-terminal region; The immediate-early protein ICP4 (infected-cell polypeptide 4) is required for efficient transcription of early and late viral genes and is thus essential for productive infection. ICP4 is a large phosphoprotein that binds DNA in a sequence specific manner as a homodimer. ICP4 represses transcription from LAT, ICP4 and ORF-P that have high-affinity a ICP4 binding site that spans the transcription initiation site. ICP4 proteins have two highly conserved regions, this family contains the C-terminal region that probably acts as an enhancer for the N-terminal region.


Pssm-ID: 281570  Cd Length: 444  Bit Score: 368.55  E-value: 2.14e-113
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10834942   1568 AAFRKPPIGTPIAGYAGPPHLDAYCPGEGVDELTSFAQIPTLWRQPLARSPEAMAEI-ARVAST-----PSHVSRSPDTA 1641
Cdd:pfam03585    1 GGFRRFPVGTVHTQTPPQSALNAYCPPGAFAELVDFPLFPEPWRPALRFDPEALADIaARVANAlpgggDYNSNEIITSA 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10834942   1642 ASEGVLCRTAVVSLRARTAWMRhQQASPEDVALVILYTANPGEHLFCVPAPGSPPggpRFDPNRGGLSFLLAALANRLCL 1721
Cdd:pfam03585   81 ASRAFGPPTATSKLRRRTAWMR-QIPDPEDVRIVVLYSPLPGEDLFCVPAPDTPP---KWSNKRGGLSFLLAALSNRLCL 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10834942   1722 PESAAWAGRWRAAPDVSALTAAGVMFLSPQDLGFAGVLEHLQRLCLKREKRLVVLDTLEDRDRPENGPRLVEEAVrYVRC 1801
Cdd:pfam03585  157 PKTSAWAGNWTGAPDVSALTAMGVLLLSTRDLAFAGAVEYLGRQCMKRKRRLIVMDTVEDRYWPPDGPAISEEHT-YMKC 235

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10834942   1802 TVSPRSQCSVRWPGHPDLATTVITSRDVLGPVVLRELETHFRRENPAAGDISLCCGSNVRYKVATRLDRVATVPMTALSY 1881
Cdd:pfam03585  236 IISPRSQCCVRWPGLLDLGRTVIASRRVFGPLTFARLEQAYAELYPEDSPLNLCRGGNVRYTVETRLGPVTCVPTSPREY 315

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10834942   1882 LAASSALVAGRQR---------PPGPDFLAGESHSHRAALKWGLYAPLRPVYVLEPKKNAIVSPDFLNR-TVCDVCRSVV 1951
Cdd:pfam03585  316 RAAVLPVFDGCKDlarqsrglgLGAPDFLCEEAHSHRAARRWGLGAPLRPVYVIEGRMNAIAGPSFLHVpTARNFCRSAL 395

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|....
gi 10834942   1952 LPPDPHAQPVVVHVPEATCSLLAREMLAHLRSS--SVVWLEGDG 1993
Cdd:pfam03585  396 LEPDPEARPLVLHIPEGTCSALAEDMVASALPPcpRITWGQGFG 439
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 1-418 1.30e-11

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 70.20  E-value: 1.30e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10834942     1 MENPPDFYSLLEMLADNGGFSPQPPATPGDPyqdvclntpsvavpptpgrqpvpprsksparaapvagslagarapfgie 80
Cdd:PHA03307    1 SDNAPDLYDLIEAAAEGGEFFPRPPATPGDA------------------------------------------------- 31

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10834942    81 gavsegsdtglrsaepPDGAHQGSPGEVVSSTADIVDVCGNETAAAAPRSCSWQKTvgdlvpagsergEPSPMDPRKSND 160
Cdd:PHA03307   32 ----------------ADDLLSGSQGQLVSDSAELAAVTVVAGAAACDRFEPPTGP------------PPGPGTEAPANE 83

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10834942   161 PvrcvsdapckptgactplavcvetlpppsgvppppppepIVNFPWTFSPLTPGPFAQHHSPTPPTPPPLSPPPPTPPPL 240
Cdd:PHA03307   84 S---------------------------------------RSTPTWSLSTLAPASPAREGSPTPPGPSSPDPPPPTPPPA 124

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10834942   241 SPPPPTPPPLSPPPPTPPPHTPPPHGSPPPTPLPSTSPPSTQTSSPSASLPLDSPPASTPPPPTPLHDRPLSPDPPALSA 320
Cdd:PHA03307  125 SPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQAALPLSSPEETARAPSSPPAEPPPSTPPAAASP 204

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10834942   321 SCQRPSPPLSPSAPRLAPAPLRSDRVPARRKSSVSEGGGPRTRGAGFQYVCRLSASARIPSPPREELELVARQPGSHAML 400
Cdd:PHA03307  205 RPPRRSSPISASASSPAPAPGRSAADDAGASSSDSSSSESSGCGWGPENECPLPRPAPITLPTRIWEASGWNGPSSRPGP 284

                         410       420
                  ....*....|....*....|..
gi 10834942   401 WR----AGARDGATEPSSGDDP 418
Cdd:PHA03307  285 ASssssPRERSPSPSPSSPGSG 306
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 408-581 4.58e-05

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 48.63  E-value: 4.58e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10834942   408 GATEPSSGDDPKVFLLALSDARRCPSYWDRLAREAVLREILPTPRGSPLRTSPGSIELpreAPLLDSDYRPFEWRCAKGR 487
Cdd:PHA03307  118 PPTPPPASPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQAALP---LSSPEETARAPSSPPAEPP 194

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10834942   488 PLPQEPVFPCPPNELGNDWAACKMWLFSRCARlvlSTLDDMSPSEDGESVLESQGCGWGPQNECPLPLPAPIVLPTRIWE 567
Cdd:PHA03307  195 PSTPPAAASPRPPRRSSPISASASSPAPAPGR---SAADDAGASSSDSSSSESSGCGWGPENECPLPRPAPITLPTRIWE 271

                         170
                  ....*....|....
gi 10834942   568 AVTRLPRPAPRTPT 581
Cdd:PHA03307  272 ASGWNGPSSRPGPA 285
 
Name Accession Description Interval E-value
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 873-1992 0e+00

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 918.79  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10834942   873 WNGPSPRPGLVSSPTGTQERYRRVQPGSGSDGSHTTAPPAVLKQALQQEVGTPATRASHPLPRPPPASYPSLGCRSRSSS 952
Cdd:PHA03307  275 WNGPSSRPGPASSSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRESSSSSTSSSSESSRGAAVSPGPSPSRSPSPS 354

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10834942   953 SSSASSSSSSSSSAPSSSEQSSAAPSSRTSSRSptrEAGAPQCAARGRGRGRGGRRGRGRRAPSP------SSETAAPPP 1026
Cdd:PHA03307  355 RPPPPADPSSPRKRPRPSRAPSSPAASAGRPTR---RRARAAVAGRARRRDATGRFPAGRPRPSPldagaaSGAFYARYP 431

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10834942  1027 PDDLDQEVWWQIPSPPAGRCWFGPLGGHRQALRGIPEVEQAAVRFLSTPGPLPVYVEEMGNCAKQYEALVSAMLNKDVKA 1106
Cdd:PHA03307  432 LLTPSGEPWPGSPPPPPGRVRYGGLGDSRPGLWDAPEVREAAARYEASPGPVPVYVPEMGDSAKQYAALVRLLYTPDREA 511

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10834942  1107 NPlnWAHHGKLSPTDAALNHIYVTKFRsSHSSPGAAVTGTVNKCIPHIASAMKKRNLLWALPHIAASVSMTRRYCKDQKE 1186
Cdd:PHA03307  512 MG--WLQNPKLTGPDQALDQFCQKKFQ-APRGSGSFITGSVARPVPHIGDAMAAGNALWALPHAAAAVAMSRRYDRAQKG 588

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10834942  1187 FMFRSLRKAYAPMASAASAEMRRpsaspisnrapvtaqstaaglipvidvstihdrvrrgvaafnsaleeglldVPEYRL 1266
Cdd:PHA03307  589 FLLQSLRRAYAPMAYPENAADTG---------------------------------------------------AGAAAP 617

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10834942  1267 VAPARPDIPAGDGFASTRPLNELVDACALECEGVVAALLRGPDGPGAvaemlssCEDGPFPRPAGH-EQWEKCRALLGSW 1345
Cdd:PHA03307  618 APAAPRPDAAAAGGASARPLRELADACVLACRAVLEALLEGPDGLSA-------VPGLAFPRPACPpRALEACPARLESW 690

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10834942  1346 LRDLLDLRSAVYAAYANG--SAPRGRQERTLAANAAALITEAIGPLLSKDPARPWRCPGSRDITSVLLRECGSRG----- 1418
Cdd:PHA03307  691 LRELRDLRDAVYLARLRGdlPVAGGREERVAAVRAVSLVARTVAPLVRYSPRRARARASAWDITDALFSNPSLVPaklae 770

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10834942  1419 -----------------EPVRSREKARRLQRVARLLADADAASSGTSEGRSR---------SAEPCYDPGPASSPEPVRa 1472
Cdd:PHA03307  771 alallepaepqrgagssPPVRAEAAFRRPGRLRRSGPAADAASRTASKRKSRshtpdggseSSGPARPPGAAARPPPAR- 849

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10834942  1473 lcaqtSAESRKRKSAPAAVLDGADNAVENPRPRLGRSRTGAGPPPVASCTRPPTPPEACRDAGPFPPKrprcfpwrdpar 1552
Cdd:PHA03307  850 -----SSESSKSKPAAAGGRARGKNGRRRPRPPEPRARPGAAAPPKAAAAAPPAGAPAPRPRPAPRVK------------ 912

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10834942  1553 imDGSLSLGDRRHRGaAFRKPPIGTPIAGYAGPPHLDAYCPGEGVDELTSFAQIPTLWRQPLARSPEAMAEIARVASTPS 1632
Cdd:PHA03307  913 --LGPMPPGGPDPRG-GFRRVPPGDLHTPAPSAAALAAYCPPEVVAELVDHPLFPEPWRPALAFDPEALAEIAARCGGPP 989

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10834942  1633 HVSRSPdtaasegVLCRTAVVSLRARTAWMRhQQASPEDVALVILYTANPGEHLFCVPAPGSPPGGPRFDPNRGGLSFLL 1712
Cdd:PHA03307  990 PRSGSA-------FGPLRASGPLRRRAAWMR-QIPDPEDVRVVVLYSPLPGEHLFGVPAPDASPGGPAWSPERGGLSFLL 1061

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10834942  1713 AALANRLCLPESAAWAGRWRAAPDVSALTAAGVMFLSPQDLGFAGVLEHLQRLCLKREKRLVVLDTLEDRDRPENGPRlV 1792
Cdd:PHA03307 1062 AALGNRLCLPDSHAWAGNWTGAPDVSALNAQGVLLLSTRDLAFAGAVEYLCLRLGSARRRLIVLDTVDPEDWPADGPA-V 1140

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10834942  1793 EEAVRYVRCTVSPRSQCSVRWPGHPDLATTVITSRDVLGPVVLRELETHFRRENPAAGDISLCCGSNVRYKVATRLDRVA 1872
Cdd:PHA03307 1141 SQYHVYLRCAVLPRAQCAVRWPAARDLARAVLTSSRVFGPGLFARVEAAFARLYPDAPPLRLCRGANVRYTVRTRLGPRT 1220

                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10834942  1873 TVPMTALSYLAASSALVAGR---------QRPPGPDFLAGESHSHRAALKWGLYAPLRPVYVLEPKKNAIVSPDFLNRTV 1943
Cdd:PHA03307 1221 RVPLPPREYRQAVLPALDGCkdmaaqaegLGLGAPDFLEGEAHSHRAANRWGLGAPLRPVYLAEGRRAAIAGPDELPAVV 1300

                        1130      1140      1150      1160
                  ....*....|....*....|....*....|....*....|....*....
gi 10834942  1944 CDVCRSVVLPPDPHAQPVVVHVpeatcSLLAREMlaHLRSSSVVWLEGD 1992
Cdd:PHA03307 1301 RAFCRAALLEPDPEAPPLVLPP-----SAAAEAA--HARAPRVTWAKSE 1342
Herpes_ICP4_C pfam03585
Herpesvirus ICP4-like protein C-terminal region; The immediate-early protein ICP4 ...
 1568-1993 2.14e-113

Herpesvirus ICP4-like protein C-terminal region; The immediate-early protein ICP4 (infected-cell polypeptide 4) is required for efficient transcription of early and late viral genes and is thus essential for productive infection. ICP4 is a large phosphoprotein that binds DNA in a sequence specific manner as a homodimer. ICP4 represses transcription from LAT, ICP4 and ORF-P that have high-affinity a ICP4 binding site that spans the transcription initiation site. ICP4 proteins have two highly conserved regions, this family contains the C-terminal region that probably acts as an enhancer for the N-terminal region.


Pssm-ID: 281570  Cd Length: 444  Bit Score: 368.55  E-value: 2.14e-113
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10834942   1568 AAFRKPPIGTPIAGYAGPPHLDAYCPGEGVDELTSFAQIPTLWRQPLARSPEAMAEI-ARVAST-----PSHVSRSPDTA 1641
Cdd:pfam03585    1 GGFRRFPVGTVHTQTPPQSALNAYCPPGAFAELVDFPLFPEPWRPALRFDPEALADIaARVANAlpgggDYNSNEIITSA 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10834942   1642 ASEGVLCRTAVVSLRARTAWMRhQQASPEDVALVILYTANPGEHLFCVPAPGSPPggpRFDPNRGGLSFLLAALANRLCL 1721
Cdd:pfam03585   81 ASRAFGPPTATSKLRRRTAWMR-QIPDPEDVRIVVLYSPLPGEDLFCVPAPDTPP---KWSNKRGGLSFLLAALSNRLCL 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10834942   1722 PESAAWAGRWRAAPDVSALTAAGVMFLSPQDLGFAGVLEHLQRLCLKREKRLVVLDTLEDRDRPENGPRLVEEAVrYVRC 1801
Cdd:pfam03585  157 PKTSAWAGNWTGAPDVSALTAMGVLLLSTRDLAFAGAVEYLGRQCMKRKRRLIVMDTVEDRYWPPDGPAISEEHT-YMKC 235

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10834942   1802 TVSPRSQCSVRWPGHPDLATTVITSRDVLGPVVLRELETHFRRENPAAGDISLCCGSNVRYKVATRLDRVATVPMTALSY 1881
Cdd:pfam03585  236 IISPRSQCCVRWPGLLDLGRTVIASRRVFGPLTFARLEQAYAELYPEDSPLNLCRGGNVRYTVETRLGPVTCVPTSPREY 315

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10834942   1882 LAASSALVAGRQR---------PPGPDFLAGESHSHRAALKWGLYAPLRPVYVLEPKKNAIVSPDFLNR-TVCDVCRSVV 1951
Cdd:pfam03585  316 RAAVLPVFDGCKDlarqsrglgLGAPDFLCEEAHSHRAARRWGLGAPLRPVYVIEGRMNAIAGPSFLHVpTARNFCRSAL 395

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|....
gi 10834942   1952 LPPDPHAQPVVVHVPEATCSLLAREMLAHLRSS--SVVWLEGDG 1993
Cdd:pfam03585  396 LEPDPEARPLVLHIPEGTCSALAEDMVASALPPcpRITWGQGFG 439
Herpes_ICP4_N pfam03584
Herpesvirus ICP4-like protein N-terminal region; The immediate-early protein ICP4 ...
 1041-1200 1.89e-61

Herpesvirus ICP4-like protein N-terminal region; The immediate-early protein ICP4 (infected-cell polypeptide 4) is required for efficient transcription of early and late viral genes and is thus essential for productive infection. ICP4 is a large phosphoprotein that binds DNA in a sequence specific manner as a homodimer. ICP4 represses transcription from LAT, ICP4 and ORF-P that have high-affinity a ICP4 binding site that spans the transcription initiation site. ICP4 proteins have two highly conserved regions, this family contains the N-terminal region that contains sites for DNA binding and homodimerization.


Pssm-ID: 367571 [Multi-domain]  Cd Length: 163  Bit Score: 207.76  E-value: 1.89e-61
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10834942   1041 PPAGRCWFGPLGGHRQALRGIPEVEQAAVRFLSTPGPLPVYVEEMGNCAKQYEALVSAMLNKDVkaNPLNWAHHGKLSPT 1120
Cdd:pfam03584    2 PPPGRVLYGGLGDSRPGLWGAPEVREARARFEASGAPAPVYVPELGDAAQQYAALVNLLYTPDA--EPLGWLQNPRLNPG 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10834942   1121 DAALNHIYvTKFRSSHSSPGAAVTGTVNKCIPHIASAMKKRNLLWALPHIAASVSMTRRYCKDQKEFMFRSLRKAYAPMA 1200
Cdd:pfam03584   80 DVALNQIC-QKISGAARNSGSAVTGSVARAVPHIGYAMAAGRALWALPHAAAAVAMSRRYDRAQKTFLLTSLRRAYAPLA 158
PHA03308 PHA03308
transcriptional regulator ICP4; Provisional
 1038-1221 1.50e-17

transcriptional regulator ICP4; Provisional


Pssm-ID: 165563 [Multi-domain]  Cd Length: 1463  Bit Score: 89.87  E-value: 1.50e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10834942  1038 IPSPPA-GRCWFGplGGHRQALRGIPEVEQAAVRFLSTPGPLPVYVEEMGNCAKQYEALVSAMLnkdvkANPLNWAHHG- 1115
Cdd:PHA03308  355 IPSPPSrGQVYHG--SGYRQSLVDDPQVREAAAEFHANPKSASVYLEEYGMPVEQLERLVEEFM-----VHPLSRVSYGy 427

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10834942  1116 ---KLSPTDAALNHIyvTKFRSSHSSPGAAVTGTVNKCIPHIASAMKKRNLLWALPHIAASVSMTRRYCKDQKEFMFRSL 1192
Cdd:PHA03308  428 ggpKLSPRDKRLCEL--CALRGPGSSEGGLSRSAVPTCLPHVAHAMRDGRVSLALPHLTELVRVCRRYDHPQKTYLLAAL 505

                         170       180
                  ....*....|....*....|....*....
gi 10834942  1193 RKAYAPMASAASAEmrRPSASPISNRAPV 1221
Cdd:PHA03308  506 RRAFVPFVFPGAAV--DPTAASASGDHPV 532
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 1-418 1.30e-11

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 70.20  E-value: 1.30e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10834942     1 MENPPDFYSLLEMLADNGGFSPQPPATPGDPyqdvclntpsvavpptpgrqpvpprsksparaapvagslagarapfgie 80
Cdd:PHA03307    1 SDNAPDLYDLIEAAAEGGEFFPRPPATPGDA------------------------------------------------- 31

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10834942    81 gavsegsdtglrsaepPDGAHQGSPGEVVSSTADIVDVCGNETAAAAPRSCSWQKTvgdlvpagsergEPSPMDPRKSND 160
Cdd:PHA03307   32 ----------------ADDLLSGSQGQLVSDSAELAAVTVVAGAAACDRFEPPTGP------------PPGPGTEAPANE 83

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10834942   161 PvrcvsdapckptgactplavcvetlpppsgvppppppepIVNFPWTFSPLTPGPFAQHHSPTPPTPPPLSPPPPTPPPL 240
Cdd:PHA03307   84 S---------------------------------------RSTPTWSLSTLAPASPAREGSPTPPGPSSPDPPPPTPPPA 124

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10834942   241 SPPPPTPPPLSPPPPTPPPHTPPPHGSPPPTPLPSTSPPSTQTSSPSASLPLDSPPASTPPPPTPLHDRPLSPDPPALSA 320
Cdd:PHA03307  125 SPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQAALPLSSPEETARAPSSPPAEPPPSTPPAAASP 204

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10834942   321 SCQRPSPPLSPSAPRLAPAPLRSDRVPARRKSSVSEGGGPRTRGAGFQYVCRLSASARIPSPPREELELVARQPGSHAML 400
Cdd:PHA03307  205 RPPRRSSPISASASSPAPAPGRSAADDAGASSSDSSSSESSGCGWGPENECPLPRPAPITLPTRIWEASGWNGPSSRPGP 284

                         410       420
                  ....*....|....*....|..
gi 10834942   401 WR----AGARDGATEPSSGDDP 418
Cdd:PHA03307  285 ASssssPRERSPSPSPSSPGSG 306
PHA03309 PHA03309
transcriptional regulator ICP4; Provisional
 1038-1256 2.14e-08

transcriptional regulator ICP4; Provisional


Pssm-ID: 165564 [Multi-domain]  Cd Length: 2033  Bit Score: 59.87  E-value: 2.14e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10834942  1038 IPSPPAGRCWFGPLGGHRQALRGIPEVEQAAVRFLSTPGPLPVYVEEMGNCAKQYEALVSAMLnkdvkANPLNWAHHG-- 1115
Cdd:PHA03309  629 LPKPPAADYVYYGKTGYRPSMAAHPDVRRAAEEFSASDAAARVYVEEFGMAVEQHERLVAEFM-----LQPLSRVSHSyg 703

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10834942  1116 --KLSPTDAALNHIYVTKFRSSHSSPGAAVTG------------TVNKCIPHIASAMKKRNLLWALPHIAASVSMTRRYC 1181
Cdd:PHA03309  704 gsRLNKTEKNLCKICLPPDGGDDRDGGGKSRGgrgggskdasrtAMATGVPHIVHAMRDGRAALALPHLMDVIRVCRRYD 783

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 10834942  1182 KDQKEFMFRSLRKAYAPMASaasaemrrPSASPisnraPVTAQSTAAGLIPVIDVSTIhdrVRRGVAAFNSALEE 1256
Cdd:PHA03309  784 ASQKTYLLSCLRLAFAPLVF--------PGASP-----PVGADDSPWPTSPIRECAAA---LREGFRALNDIRAE 842
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 408-581 4.58e-05

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 48.63  E-value: 4.58e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10834942   408 GATEPSSGDDPKVFLLALSDARRCPSYWDRLAREAVLREILPTPRGSPLRTSPGSIELpreAPLLDSDYRPFEWRCAKGR 487
Cdd:PHA03307  118 PPTPPPASPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQAALP---LSSPEETARAPSSPPAEPP 194

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10834942   488 PLPQEPVFPCPPNELGNDWAACKMWLFSRCARlvlSTLDDMSPSEDGESVLESQGCGWGPQNECPLPLPAPIVLPTRIWE 567
Cdd:PHA03307  195 PSTPPAAASPRPPRRSSPISASASSPAPAPGR---SAADDAGASSSDSSSSESSGCGWGPENECPLPRPAPITLPTRIWE 271

                         170
                  ....*....|....
gi 10834942   568 AVTRLPRPAPRTPT 581
Cdd:PHA03307  272 ASGWNGPSSRPGPA 285
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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