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Conserved domains on  [gi|50845399|ref|NP_067044|]
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lymphocyte antigen 6 complex locus protein G5b precursor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TFP_LU_ECD_Ly6G5b cd23544
extracellular domain (ECD) found in lymphocyte antigen 6 complex locus protein G5b (Ly6G5b) ...
 25-106 6.12e-49

extracellular domain (ECD) found in lymphocyte antigen 6 complex locus protein G5b (Ly6G5b) and similar proteins; Ly6G5b is a glycosylated, potentially secreted protein which could act as ligand for other cell-surface receptors and could thus potentially have a role in cell signaling. It contains an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


:

Pssm-ID: 467074  Cd Length: 82  Bit Score: 154.10  E-value: 6.12e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50845399  25 IRTCHFCLVEDPSVGCISGSEKCTISSSSLCMVITIYYDVKVRFIVRGCGQYISYRCQEKRNTYFAEYWYQAQCCQYDYC 104
Cdd:cd23544   1 ARRCHLCLLEDPSIGCISGSEKCTPSSGEPCMTITIYYEGKVRFLVRGCGQHSSYRCGERKKTYVSGYWYNARCCQYDYC 80


                ..
gi 50845399 105 NS 106
Cdd:cd23544  81 NS 82
 
Name Accession Description Interval E-value
TFP_LU_ECD_Ly6G5b cd23544
extracellular domain (ECD) found in lymphocyte antigen 6 complex locus protein G5b (Ly6G5b) ...
 25-106 6.12e-49

extracellular domain (ECD) found in lymphocyte antigen 6 complex locus protein G5b (Ly6G5b) and similar proteins; Ly6G5b is a glycosylated, potentially secreted protein which could act as ligand for other cell-surface receptors and could thus potentially have a role in cell signaling. It contains an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467074  Cd Length: 82  Bit Score: 154.10  E-value: 6.12e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50845399  25 IRTCHFCLVEDPSVGCISGSEKCTISSSSLCMVITIYYDVKVRFIVRGCGQYISYRCQEKRNTYFAEYWYQAQCCQYDYC 104
Cdd:cd23544   1 ARRCHLCLLEDPSIGCISGSEKCTPSSGEPCMTITIYYEGKVRFLVRGCGQHSSYRCGERKKTYVSGYWYNARCCQYDYC 80


                ..
gi 50845399 105 NS 106
Cdd:cd23544  81 NS 82
 
Name Accession Description Interval E-value
TFP_LU_ECD_Ly6G5b cd23544
extracellular domain (ECD) found in lymphocyte antigen 6 complex locus protein G5b (Ly6G5b) ...
 25-106 6.12e-49

extracellular domain (ECD) found in lymphocyte antigen 6 complex locus protein G5b (Ly6G5b) and similar proteins; Ly6G5b is a glycosylated, potentially secreted protein which could act as ligand for other cell-surface receptors and could thus potentially have a role in cell signaling. It contains an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467074  Cd Length: 82  Bit Score: 154.10  E-value: 6.12e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50845399  25 IRTCHFCLVEDPSVGCISGSEKCTISSSSLCMVITIYYDVKVRFIVRGCGQYISYRCQEKRNTYFAEYWYQAQCCQYDYC 104
Cdd:cd23544   1 ARRCHLCLLEDPSIGCISGSEKCTPSSGEPCMTITIYYEGKVRFLVRGCGQHSSYRCGERKKTYVSGYWYNARCCQYDYC 80


                ..
gi 50845399 105 NS 106
Cdd:cd23544  81 NS 82
TFP cd00117
three-fingered protein (TFP) fold found in Ly6/uPAR (LU) and snake toxin superfamily; The LU ...
 27-105 1.29e-07

three-fingered protein (TFP) fold found in Ly6/uPAR (LU) and snake toxin superfamily; The LU (also known as Ly-6 antigen/uPA receptor)-like extracellular domain (ECD) occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. It is a structural domain involved in protein-protein interactions, tolerating an unusual degree of variation and binding with high specificity to a broad spectrum of targets. The snake toxin domain is present in short and long neurotoxins, cytotoxins, and short toxins, and in other miscellaneous venom peptides. The toxin acts by binding to the nicotinic acetylcholine receptors in the postsynaptic membrane of skeletal muscles and preventing the binding of acetylcholine, thereby blocking the excitation of muscles. Both the LU-like ECD and the snake toxin domain belong to three-fingered protein (TFP) fold, which is characterized by containing 70 to 100 amino acids including eight to ten cysteine residues spaced at conserved distances.


Pssm-ID: 467060  Cd Length: 81  Bit Score: 47.48  E-value: 1.29e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50845399  27 TCHFCLVEDPSVGCIS--GSEKCTiSSSSLCMVITIYYDVKVRFIVRGCGQYISYRCQEKRNTYFAEYWYQAQCCQYDYC 104
Cdd:cd00117   2 KCYQCNSSNDPNCCNSspTLVTCS-SPETFCRKIVGKVGGGETLVIRGCATECECGCTECCSGTGTSGTTCTSCCDTDLC 80


                .
gi 50845399 105 N 105
Cdd:cd00117  81 N 81
TFP_LU_ECD_Ly6G5c cd23545
extracellular domain (ECD) found in lymphocyte antigen 6 complex locus protein G5c (Ly6G5c) ...
 28-106 6.62e-05

extracellular domain (ECD) found in lymphocyte antigen 6 complex locus protein G5c (Ly6G5c) and similar proteins; Ly6G5c is a glycosylated, potentially secreted protein which could act as ligand for other cell-surface receptors and could thus potentially have a role in cell signaling. Ly6G5c may have a role in hematopoietic cell differentiation. It contains an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467075  Cd Length: 88  Bit Score: 40.25  E-value: 6.62e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50845399  28 CHFCLVEDPSVGCISGSEKCTISSSSLCMVITIYYDVKVRFIVRGC-GQYISYRCQEKRNTYFAEYWYQAQCCQYDYCNS 106
Cdd:cd23545   5 CYRCLLETKELGCLLGSDICLTPKGSSCITLHIKNGSGDEVMVSDCrSKEQMSECSLTRASPVFGFWIFSQCCFLDFCNN 84
TFP_LU_ECD_PATE3 cd23579
extracellular domain (ECD) found in prostate and testis expressed protein 3 (PATE3) and ...
 26-105 4.42e-04

extracellular domain (ECD) found in prostate and testis expressed protein 3 (PATE3) and similar proteins; PATE3 (also called acrosomal vesicle protein HEL-127, or PATE-like protein DJ (PATE-DJ)) is a member of the prostate and testis expression (PATE)-like family of proteins that likely play important roles in reproductive and neuronal physiology. They are expressed mainly in the male genital tract and involved in sperm-oolemma fusion and penetration, but not sperm-zona binding. PATE3 contains an extracellular domain (ECD), which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467109  Cd Length: 80  Bit Score: 37.80  E-value: 4.42e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50845399  26 RTCHFCLVEDpsvGCISGSEKCTISSSSLCMVITIYYDVKVRFIVRGCGQYisyrCQEKRnTYFAEYWYQAQCCQYDYCN 105
Cdd:cd23579   8 ITCHLRTVSD---RCRRGFGTCTAQKDESCMRLRIYQGDTLQLSYMVCQKF----CRDLT-YHFNNRTYVHTCCNKDYCN 79
TFP_LU_ECD_PATE4 cd23580
extracellular domain (ECD) found in prostate and testis expressed protein 4 (PATE4) and ...
 27-106 4.52e-04

extracellular domain (ECD) found in prostate and testis expressed protein 4 (PATE4) and similar proteins; PATE4, also called prostate and testis expressed 4, or PATE-like protein B) is a member of the prostate and testis expression (PATE)-like family of proteins that likely play important roles in reproductive and neuronal physiology. They are expressed mainly in the male genital tract and involved in sperm-oolemma fusion and penetration, but not sperm-zona binding. PATE4 may modulate the function of nicotinic acetylcholine receptors and enhance sperm motility. PATE4 contains an extracellular domain (ECD), which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467110  Cd Length: 79  Bit Score: 37.77  E-value: 4.52e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50845399  27 TCHFCLVEDPSvGCISGSEKCTISSSSLCMVITIYYDVKVRFIVRGCgqyiSYRCQEKRNTYFAEYWYqAQCCQYDYCNS 106
Cdd:cd23580   5 ICNVCIYSKNS-RCMSGQGRCTAKPGGSCSTISYYRGSKHLYSKHMC----KYHCKEEQYYKGDLLRY-TMCCEKNLCNS 78
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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