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Conserved domains on  [gi|12621130|ref|NP_075242|]
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slit homolog 1 protein precursor [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LamG smart00282
Laminin G domain;
1186-1319 3.70e-38

Laminin G domain;


:

Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 139.40  E-value: 3.70e-38
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12621130    1186 NITLQVSTAEDNGILLYNG---DNDHIAVELYQGHVRVSYDPGSYPSSAIYSAETINDGQFHTVELVTFDQMVNLSIDGG 1262
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGskgGGDYLALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVERNGRSVTLSVDGG 80

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 12621130    1263 SPMTMDNFGKHYTLNSEAPLYVGGMPVDvnsaaFRLWQILNGTSFHGCIRNLYINNE 1319
Cdd:smart00282   81 NRVSGESPGGLTILNLDGPLYLGGLPED-----LKLPPLPVTPGFRGCIRNLKVNGK 132
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
43-217 1.85e-28

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 120.04  E-value: 1.85e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12621130   43 TTVDCHGTGLQAIPKNIPRNT--ERLELNGNNITRIHKnDFAGLKQLRVLQLMENQIGAVERgAFDDMKELERLRLNRNQ 120
Cdd:COG4886  116 ESLDLSGNQLTDLPEELANLTnlKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQ 193

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12621130  121 LQVLPELLfQNNQALSRLDLSENSLQAVPrKAFRGATDLKNLQLDKNQISCIEEgaFRALRGLEVLTLNNNNITTIPVSS 200
Cdd:COG4886  194 ITDLPEPL-GNLTNLEELDLSGNQLTDLP-EPLANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPPLA 269

                        170
                 ....*....|....*..
gi 12621130  201 fnHMPKLRTFRLHSNHL 217
Cdd:COG4886  270 --NLTNLKTLDLSNNQL 284
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
543-820 2.86e-23

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 104.63  E-value: 2.86e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12621130  543 TELRLNNNEisileatgLFKKLSHLKKINLSNNKVSEIEDgTFEGATSVSELHLTANQLESVRSGmFRGLDGLRTLMLRN 622
Cdd:COG4886   99 TELDLSGNE--------ELSNLTNLESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDLPEP-LGNLTNLKSLDLSN 168

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12621130  623 NRISCIhNDSFTGLRNVRLLSLYDNHITTIsPGAFDTLQALSTLNLlanpfncncqlawlgdwlrkrkivtgnprcqnpd 702
Cdd:COG4886  169 NQLTDL-PEELGNLTNLKELDLSNNQITDL-PEPLGNLTNLEELDL---------------------------------- 212

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12621130  703 flrqiplqdvafpdfrceegqeevgclprpqcpqecacldtvvrcSNKHLQALPKGIP--KNVTELYLDGNQFTLVPgQL 780
Cdd:COG4886  213 ---------------------------------------------SGNQLTDLPEPLAnlTNLETLDLSNNQLTDLP-EL 246

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 12621130  781 STFKYLQLVDLSNNKISSLSNSSftNMSQLTTLILSYNAL 820
Cdd:COG4886  247 GNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQL 284
PCC super family cl28216
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 644-730 5.01e-13

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


The actual alignment was detected with superfamily member TIGR00864:

Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 74.73  E-value: 5.01e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12621130    644 LYDNHITTISPGAFDTLQALSTLNLLANPFNCNCQLAWLGDWLRKRKIVTGNPR---CQNPDFLRQIPLQDVAFPDFRCe 720
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVRQPEaalCAGPGALAGQPLLGIPLLDSGC- 80

                           90
                   ....*....|
gi 12621130    721 eGQEEVGCLP 730
Cdd:TIGR00864   81 -DEEYVACLK 89
LRR_8 pfam13855
Leucine rich repeat;
312-369 2.18e-11

Leucine rich repeat;


:

Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 60.62  E-value: 2.18e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 12621130    312 TEIRLELNGIKSIPPGAFSPYRKLRRIDLSNNQIAEIAPDAFQGLRSLNSLVLYGNKI 369
Cdd:pfam13855    4 RSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PCC super family cl28216
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 842-1002 1.35e-10

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


The actual alignment was detected with superfamily member TIGR00864:

Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 66.64  E-value: 1.35e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12621130    842 NDVSTLQEGIFADVTSLSHLAIGANPLYCDCHLRWLSSWVK---TGYKEPGIARCAGPPEMEGKLLLTTPAKKFECqGPP 918
Cdd:TIGR00864    5 NKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEekgVKVRQPEAALCAGPGALAGQPLLGIPLLDSGC-DEE 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12621130    919 SLAvqakCDPCLSSpcqnQGTCHNDPLEVYRCTCPSGYKGRNCEVSLDSCSSNPCGNGGT----CHAQEGEDAGFT---- 990
Cdd:TIGR00864   84 YVA----CLKDNSS----GGGAARSELVIFSAAHEGLFQPEACNAFCFSAGHGLAALGEQgeclCGAAQPSEANFAcesl 155

                          170
                   ....*....|..
gi 12621130    991 CSCPSGFEGLTC 1002
Cdd:TIGR00864  156 CSGPPPPPAAAC 167
LRR_8 pfam13855
Leucine rich repeat;
389-441 6.91e-09

Leucine rich repeat;


:

Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 53.30  E-value: 6.91e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 12621130    389 NANKINCIRPDAFQDLQNLSLLSLYDNKIQSLAKGTFTSLRAIQTLHLAQNPF 441
Cdd:pfam13855    9 SNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PCC super family cl28216
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 188-328 5.01e-08

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


The actual alignment was detected with superfamily member TIGR00864:

Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 58.17  E-value: 5.01e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12621130    188 LNNNNITTIPVSSFNHMPKLRTFRLHSNHLFCDCHLAWLSQWLRQ------RPTIglfTQCSGPASLRGLNVAEVQKSEF 261
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEkgvkvrQPEA---ALCAGPGALAGQPLLGIPLLDS 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12621130    262 SC----------SGQGEAAQVPACTLSSGS---------CPAMC-SCSNGIVDCRGKGLTAIPANLPETMTEIRLELNGI 321
Cdd:TIGR00864   79 GCdeeyvaclkdNSSGGGAARSELVIFSAAheglfqpeaCNAFCfSAGHGLAALGEQGECLCGAAQPSEANFACESLCSG 158


                   ....*..
gi 12621130    322 KSIPPGA 328
Cdd:TIGR00864  159 PPPPPAA 165
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1085-1119 2.08e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.71  E-value: 2.08e-06
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 12621130 1085 DDCKD-HQCQNGAQCVDEINSYACLCAEGYSGQLCE 1119
Cdd:cd00054    3 DECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1005-1041 4.51e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.55  E-value: 4.51e-06
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 12621130 1005 NTDDCV-KHDCVNGGVCVDGIGNYTCQCPLQYTGRACE 1041
Cdd:cd00054    1 DIDECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1044-1080 6.94e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.16  E-value: 6.94e-06
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 12621130 1044 VDFCSPDlNPCQHEAQCVGTPEGPRCECVPGYTGDNC 1080
Cdd:cd00054    2 IDECASG-NPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
PCC super family cl28216
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 412-475 2.59e-05

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


The actual alignment was detected with superfamily member TIGR00864:

Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 49.31  E-value: 2.59e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 12621130    412 LYDNKIQSLAKGTFTSLRAIQTLHLAQNPFICDCNLKWLADFLRTNPIETT---GARCASPRRLANK 475
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVRqpeAALCAGPGALAGQ 68
LRRNT smart00013
Leucine rich repeat N-terminal domain;
512-544 1.64e-04

Leucine rich repeat N-terminal domain;


:

Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 40.38  E-value: 1.64e-04
                            10        20        30
                    ....*....|....*....|....*....|...
gi 12621130     512 ACPHKCRCEASVVECSGLKLSKIPERIPQSTTE 544
Cdd:smart00013    1 ACPAPCNCSGTAVDCSGRGLTEVPLDLPPDTTL 33
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 733-760 2.18e-03

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


:

Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 36.84  E-value: 2.18e-03
                           10        20
                   ....*....|....*....|....*...
gi 12621130    733 QCPQECACLDTVVRCSNKHLQALPKGIP 760
Cdd:pfam01462    1 ACPVPCHCSATVVNCSDRGLTAVPRDLP 28
 
Name Accession Description Interval E-value
LamG smart00282
Laminin G domain;
1186-1319 3.70e-38

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 139.40  E-value: 3.70e-38
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12621130    1186 NITLQVSTAEDNGILLYNG---DNDHIAVELYQGHVRVSYDPGSYPSSAIYSAETINDGQFHTVELVTFDQMVNLSIDGG 1262
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGskgGGDYLALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVERNGRSVTLSVDGG 80

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 12621130    1263 SPMTMDNFGKHYTLNSEAPLYVGGMPVDvnsaaFRLWQILNGTSFHGCIRNLYINNE 1319
Cdd:smart00282   81 NRVSGESPGGLTILNLDGPLYLGGLPED-----LKLPPLPVTPGFRGCIRNLKVNGK 132
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 1164-1317 3.92e-37

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 137.16  E-value: 3.92e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12621130 1164 SVNFvDRDTYLQFTDLQN-WPRANITLQVSTAEDNGILLYNGD---NDHIAVELYQGHVRVSYDPGSypSSAIYSAET-I 1238
Cdd:cd00110    1 GVSF-SGSSYVRLPTLPApRTRLSISFSFRTTSPNGLLLYAGSqngGDFLALELEDGRLVLRYDLGS--GSLVLSSKTpL 77

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 12621130 1239 NDGQFHTVELVTFDQMVNLSIDGGSPMTMDNFGKHYTLNSEAPLYVGGMPVDVnsaafRLWQILNGTSFHGCIRNLYIN 1317
Cdd:cd00110   78 NDGQWHSVSVERNGRSVTLSVDGERVVESGSPGGSALLNLDGPLYLGGLPEDL-----KSPGLPVSPGFVGCIRDLKVN 151
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 1191-1319 4.24e-34

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 127.54  E-value: 4.24e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12621130   1191 VSTAEDNGILLYNGD--NDHIAVELYQGHVRVSYDPGSYPSSAIYSAETINDGQFHTVELVTFDQMVNLSIDGGSPMTMD 1268
Cdd:pfam02210    1 FRTRQPNGLLLYAGGggSDFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVSSL 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 12621130   1269 NFGKHYTLNSEAPLYVGGMPVDVnsaafRLWQILNGTSFHGCIRNLYINNE 1319
Cdd:pfam02210   81 PPGESLLLNLNGPLYLGGLPPLL-----LLPALPVRAGFVGCIRDVRVNGE 126
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
43-217 1.85e-28

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 120.04  E-value: 1.85e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12621130   43 TTVDCHGTGLQAIPKNIPRNT--ERLELNGNNITRIHKnDFAGLKQLRVLQLMENQIGAVERgAFDDMKELERLRLNRNQ 120
Cdd:COG4886  116 ESLDLSGNQLTDLPEELANLTnlKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQ 193

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12621130  121 LQVLPELLfQNNQALSRLDLSENSLQAVPrKAFRGATDLKNLQLDKNQISCIEEgaFRALRGLEVLTLNNNNITTIPVSS 200
Cdd:COG4886  194 ITDLPEPL-GNLTNLEELDLSGNQLTDLP-EPLANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPPLA 269

                        170
                 ....*....|....*..
gi 12621130  201 fnHMPKLRTFRLHSNHL 217
Cdd:COG4886  270 --NLTNLKTLDLSNNQL 284
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
543-820 2.86e-23

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 104.63  E-value: 2.86e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12621130  543 TELRLNNNEisileatgLFKKLSHLKKINLSNNKVSEIEDgTFEGATSVSELHLTANQLESVRSGmFRGLDGLRTLMLRN 622
Cdd:COG4886   99 TELDLSGNE--------ELSNLTNLESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDLPEP-LGNLTNLKSLDLSN 168

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12621130  623 NRISCIhNDSFTGLRNVRLLSLYDNHITTIsPGAFDTLQALSTLNLlanpfncncqlawlgdwlrkrkivtgnprcqnpd 702
Cdd:COG4886  169 NQLTDL-PEELGNLTNLKELDLSNNQITDL-PEPLGNLTNLEELDL---------------------------------- 212

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12621130  703 flrqiplqdvafpdfrceegqeevgclprpqcpqecacldtvvrcSNKHLQALPKGIP--KNVTELYLDGNQFTLVPgQL 780
Cdd:COG4886  213 ---------------------------------------------SGNQLTDLPEPLAnlTNLETLDLSNNQLTDLP-EL 246

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 12621130  781 STFKYLQLVDLSNNKISSLSNSSftNMSQLTTLILSYNAL 820
Cdd:COG4886  247 GNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQL 284
LRR_8 pfam13855
Leucine rich repeat;
589-649 1.16e-13

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 66.78  E-value: 1.16e-13
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 12621130    589 TSVSELHLTANQLESVRSGMFRGLDGLRTLMLRNNRISCIHNDSFTGLRNVRLLSLYDNHI 649
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 644-730 5.01e-13

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 74.73  E-value: 5.01e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12621130    644 LYDNHITTISPGAFDTLQALSTLNLLANPFNCNCQLAWLGDWLRKRKIVTGNPR---CQNPDFLRQIPLQDVAFPDFRCe 720
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVRQPEaalCAGPGALAGQPLLGIPLLDSGC- 80

                           90
                   ....*....|
gi 12621130    721 eGQEEVGCLP 730
Cdd:TIGR00864   81 -DEEYVACLK 89
LRR_8 pfam13855
Leucine rich repeat;
159-217 2.17e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 63.31  E-value: 2.17e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 12621130    159 LKNLQLDKNQISCIEEGAFRALRGLEVLTLNNNNITTIPVSSFNHMPKLRTFRLHSNHL 217
Cdd:pfam13855    3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
312-369 2.18e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 60.62  E-value: 2.18e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 12621130    312 TEIRLELNGIKSIPPGAFSPYRKLRRIDLSNNQIAEIAPDAFQGLRSLNSLVLYGNKI 369
Cdd:pfam13855    4 RSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 530-673 8.97e-11

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 63.27  E-value: 8.97e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12621130  530 KLSKIpERIPQST--TELRLNNNEISILEatGLfKKLSHLKKINLSNNKVSEIEDgtFEGATSVSELHLTANQLES---- 603
Cdd:cd21340   35 KITKI-ENLEFLTnlTHLYLQNNQIEKIE--NL-ENLVNLKKLYLGGNRISVVEG--LENLTNLEELHIENQRLPPgekl 108

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 12621130  604 ---VRSgMFRGLDGLRTLMLRNNRISCIhnDSFTGLRNVRLLSLYDNHITTISP--GAFDTLQALSTLNLLANPF 673
Cdd:cd21340  109 tfdPRS-LAALSNSLRVLNISGNNIDSL--EPLAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGNPV 180
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 66-217 1.06e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 63.27  E-value: 1.06e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12621130   66 LELNGNNITRIhkNDFAGLKQLRVLQLMENQIGAVErgAFDDMKELERLRLNRNQLQVLPELlfQNNQALSRLDLSENSL 145
Cdd:cd21340    7 LYLNDKNITKI--DNLSLCKNLKVLYLYDNKITKIE--NLEFLTNLTHLYLQNNQIEKIENL--ENLVNLKKLYLGGNRI 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 12621130  146 QAVprKAFRGATDLKNLQLDKNQIS-----CIEEGAFRALRG-LEVLTLNNNNITTIpvSSFNHMPKLRTFRLHSNHL 217
Cdd:cd21340   81 SVV--EGLENLTNLEELHIENQRLPpgeklTFDPRSLAALSNsLRVLNISGNNIDSL--EPLAPLRNLEQLDASNNQI 154
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 842-1002 1.35e-10

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 66.64  E-value: 1.35e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12621130    842 NDVSTLQEGIFADVTSLSHLAIGANPLYCDCHLRWLSSWVK---TGYKEPGIARCAGPPEMEGKLLLTTPAKKFECqGPP 918
Cdd:TIGR00864    5 NKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEekgVKVRQPEAALCAGPGALAGQPLLGIPLLDSGC-DEE 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12621130    919 SLAvqakCDPCLSSpcqnQGTCHNDPLEVYRCTCPSGYKGRNCEVSLDSCSSNPCGNGGT----CHAQEGEDAGFT---- 990
Cdd:TIGR00864   84 YVA----CLKDNSS----GGGAARSELVIFSAAHEGLFQPEACNAFCFSAGHGLAALGEQgeclCGAAQPSEANFAcesl 155

                          170
                   ....*....|..
gi 12621130    991 CSCPSGFEGLTC 1002
Cdd:TIGR00864  156 CSGPPPPPAAAC 167
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
529-818 1.48e-10

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 65.87  E-value: 1.48e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12621130   529 LKLSKIPERIPQSTTELRLNNNEISILEATglfkKLSHLKKINLSNNKVSEIEDGTfegATSVSELHLTANQLESVRSgm 608
Cdd:PRK15370  188 LGLTTIPACIPEQITTLILDNNELKSLPEN----LQGNIKTLYANSNQLTSIPATL---PDTIQEMELSINRITELPE-- 258

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12621130   609 fRGLDGLRTLMLRNNRISCIHNDSFTGLRNvrlLSLYDNHITTIsPGAFDTlqALSTLNLLANpfncncQLAWLGDWLrk 688
Cdd:PRK15370  259 -RLPSALQSLDLFHNKISCLPENLPEELRY---LSVYDNSIRTL-PAHLPS--GITHLNVQSN------SLTALPETL-- 323

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12621130   689 rkivtgnprcqnPDFLRQIplqdvafpdfrcEEGQEEVGCLPRpQCPQECACLDTvvrcSNKHLQALPKGIPKNVTELYL 768
Cdd:PRK15370  324 ------------PPGLKTL------------EAGENALTSLPA-SLPPELQVLDV----SKNQITVLPETLPPTITTLDV 374

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 12621130   769 DGNQFTLVPGQLSTfkYLQLVDLSNNKISSLSNS--SFTNMS-QLTTLILSYN 818
Cdd:PRK15370  375 SRNALTNLPENLPA--ALQIMQASRNNLVRLPESlpHFRGEGpQPTRIIVEYN 425
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
28-197 3.66e-09

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 61.64  E-value: 3.66e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12621130    28 RLGATACPALCTCTGTTVDCHGTGLQAIPKNIPRNTERLELNGNNITRI-------------HKNDFAGLKQ-----LRV 89
Cdd:PRK15370  187 ILGLTTIPACIPEQITTLILDNNELKSLPENLQGNIKTLYANSNQLTSIpatlpdtiqemelSINRITELPErlpsaLQS 266

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12621130    90 LQLMENQIGAVERGAFDdmkELERLRLNRNQLQVLPELLfqnNQALSRLDLSENSLQAVPRKAFRGatdLKNLQLDKNQI 169
Cdd:PRK15370  267 LDLFHNKISCLPENLPE---ELRYLSVYDNSIRTLPAHL---PSGITHLNVQSNSLTALPETLPPG---LKTLEAGENAL 337

                         170       180
                  ....*....|....*....|....*...
gi 12621130   170 SCIEEGAFRALRgleVLTLNNNNITTIP 197
Cdd:PRK15370  338 TSLPASLPPELQ---VLDVSKNQITVLP 362
LRR_8 pfam13855
Leucine rich repeat;
389-441 6.91e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 53.30  E-value: 6.91e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 12621130    389 NANKINCIRPDAFQDLQNLSLLSLYDNKIQSLAKGTFTSLRAIQTLHLAQNPF 441
Cdd:pfam13855    9 SNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 131-671 4.67e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 57.94  E-value: 4.67e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12621130   131 NNQALSRLDLSENSLQAVPRKAFRGATDLKNLQLDKNQISC-IEEGAFRALRGLEVLTLNNNNIT-TIPVSSfnhMPKLR 208
Cdd:PLN00113   67 NSSRVVSIDLSGKNISGKISSAIFRLPYIQTINLSNNQLSGpIPDDIFTTSSSLRYLNLSNNNFTgSIPRGS---IPNLE 143

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12621130   209 TFRLHSNHLFCDCHLawlsqwlrqrpTIGLFTqcsgpaSLRGLNVAevqksefscsGQGEAAQVPACTLSSGSCPAMCSC 288
Cdd:PLN00113  144 TLDLSNNMLSGEIPN-----------DIGSFS------SLKVLDLG----------GNVLVGKIPNSLTNLTSLEFLTLA 196

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12621130   289 SNGIVDcrgkgltAIPANLPE--TMTEIRLELNGIKSIPPGAFSPYRKLRRIDLSNNQIAEIAPDAFQGLRSLNSLVLYG 366
Cdd:PLN00113  197 SNQLVG-------QIPRELGQmkSLKWIYLGYNNLSGEIPYEIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQ 269

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12621130   367 NKITD-LPRGVFGgLYTLQLLLLNANKINCIRPDAFQDLQNLSLLSLYDNKIQSLAKGTFTSLRAIQTLHLAQNPFICDC 445
Cdd:PLN00113  270 NKLSGpIPPSIFS-LQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFSGEI 348

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12621130   446 --------NLKWLAdfLRTNPI--ETTGARCASPR-----RLANKRIGQIKSKKFRCSAKEQYFIpgtEDYHLNSECTSD 510
Cdd:PLN00113  349 pknlgkhnNLTVLD--LSTNNLtgEIPEGLCSSGNlfkliLFSNSLEGEIPKSLGACRSLRRVRL---QDNSFSGELPSE 423

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12621130   511 vacphkcrceasvvecsglkLSKIPeripqSTTELRLNNNEISILEATGLFkKLSHLKKINLSNNKVS-EIEDgtFEGAT 589
Cdd:PLN00113  424 --------------------FTKLP-----LVYFLDISNNNLQGRINSRKW-DMPSLQMLSLARNKFFgGLPD--SFGSK 475

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12621130   590 SVSELHLTANQLESVRSGMFRGLDGLRTLMLRNNRISCIHNDSFTGLRNVRLLSLYDNHITTISPGAFDTLQALSTLNLL 669
Cdd:PLN00113  476 RLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLS 555


                  ..
gi 12621130   670 AN 671
Cdd:PLN00113  556 QN 557
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 188-328 5.01e-08

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 58.17  E-value: 5.01e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12621130    188 LNNNNITTIPVSSFNHMPKLRTFRLHSNHLFCDCHLAWLSQWLRQ------RPTIglfTQCSGPASLRGLNVAEVQKSEF 261
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEkgvkvrQPEA---ALCAGPGALAGQPLLGIPLLDS 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12621130    262 SC----------SGQGEAAQVPACTLSSGS---------CPAMC-SCSNGIVDCRGKGLTAIPANLPETMTEIRLELNGI 321
Cdd:TIGR00864   79 GCdeeyvaclkdNSSGGGAARSELVIFSAAheglfqpeaCNAFCfSAGHGLAALGEQGECLCGAAQPSEANFACESLCSG 158


                   ....*..
gi 12621130    322 KSIPPGA 328
Cdd:TIGR00864  159 PPPPPAA 165
LRRCT smart00082
Leucine rich repeat C-terminal domain;
866-915 5.67e-07

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 47.81  E-value: 5.67e-07
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 12621130     866 NPLYCDCHLRWLSSWV--KTGYKEPGIARCAGPPEMEGKLLLTTPAkKFECQ 915
Cdd:smart00082    1 NPFICDCELRWLLRWLqaNEHLQDPVDLRCASPSSLRGPLLELLHS-EFKCP 51
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1085-1119 2.08e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.71  E-value: 2.08e-06
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 12621130 1085 DDCKD-HQCQNGAQCVDEINSYACLCAEGYSGQLCE 1119
Cdd:cd00054    3 DECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1005-1041 4.51e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.55  E-value: 4.51e-06
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 12621130 1005 NTDDCV-KHDCVNGGVCVDGIGNYTCQCPLQYTGRACE 1041
Cdd:cd00054    1 DIDECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1044-1080 6.94e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.16  E-value: 6.94e-06
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 12621130 1044 VDFCSPDlNPCQHEAQCVGTPEGPRCECVPGYTGDNC 1080
Cdd:cd00054    2 IDECASG-NPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 927-962 8.96e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.78  E-value: 8.96e-06
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 12621130  927 DPCLS-SPCQNQGTCHNDPlEVYRCTCPSGYKGRNCE 962
Cdd:cd00054    3 DECASgNPCQNGGTCVNTV-GSYRCSCPPGYTGRNCE 38
LRRNT smart00013
Leucine rich repeat N-terminal domain;
33-64 1.28e-05

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 43.46  E-value: 1.28e-05
                            10        20        30
                    ....*....|....*....|....*....|..
gi 12621130      33 ACPALCTCTGTTVDCHGTGLQAIPKNIPRNTE 64
Cdd:smart00013    1 ACPAPCNCSGTAVDCSGRGLTEVPLDLPPDTT 32
LRRCT smart00082
Leucine rich repeat C-terminal domain;
671-719 1.55e-05

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 43.57  E-value: 1.55e-05
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|.
gi 12621130     671 NPFNCNCQLAWLGDWLRKRKIV--TGNPRCQNPDFLRQiPLQDVAFPDFRC 719
Cdd:smart00082    1 NPFICDCELRWLLRWLQANEHLqdPVDLRCASPSSLRG-PLLELLHSEFKC 50
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
296-373 2.48e-05

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 48.92  E-value: 2.48e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12621130   296 RGKGLTAIPANLPETMTEIRLELNGIKSIP---PGAfspyrkLRRIDLSNNQIAEIAPDAFQGLRSLNslvLYGNKITDL 372
Cdd:PRK15370  228 NSNQLTSIPATLPDTIQEMELSINRITELPerlPSA------LQSLDLFHNKISCLPENLPEELRYLS---VYDNSIRTL 298


                  .
gi 12621130   373 P 373
Cdd:PRK15370  299 P 299
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 412-475 2.59e-05

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 49.31  E-value: 2.59e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 12621130    412 LYDNKIQSLAKGTFTSLRAIQTLHLAQNPFICDCNLKWLADFLRTNPIETT---GARCASPRRLANK 475
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVRqpeAALCAGPGALAGQ 68
EGF_CA smart00179
Calcium-binding EGF-like domain;
1085-1119 4.69e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.85  E-value: 4.69e-05
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 12621130    1085 DDCK-DHQCQNGAQCVDEINSYACLCAEGYS-GQLCE 1119
Cdd:smart00179    3 DECAsGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
LRRNT smart00013
Leucine rich repeat N-terminal domain;
282-313 6.63e-05

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 41.15  E-value: 6.63e-05
                            10        20        30
                    ....*....|....*....|....*....|..
gi 12621130     282 CPAMCSCSNGIVDCRGKGLTAIPANLPETMTE 313
Cdd:smart00013    2 CPAPCNCSGTAVDCSGRGLTEVPLDLPPDTTL 33
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 114-374 7.93e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 45.55  E-value: 7.93e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12621130  114 LRLNRNQLQVLPEL-LFQNnqaLSRLDLSENSLQAVPrkAFRGATDLKNLQLDKNQISCIEEgaFRALRGLEVLTLNNNN 192
Cdd:cd21340    7 LYLNDKNITKIDNLsLCKN---LKVLYLYDNKITKIE--NLEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNR 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12621130  193 ITTipVSSFNHMPKLRTfrLHsnhlfcdchlawLSqwlRQRPTIGlFTQCSGPASLRGLnvaevqksefscsgqgeaaqv 272
Cdd:cd21340   80 ISV--VEGLENLTNLEE--LH------------IE---NQRLPPG-EKLTFDPRSLAAL--------------------- 118

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12621130  273 pACTLSsgscpamcscsngIVDCRGkgltaipanlpetmteirlelNGIKSIPPgaFSPYRKLRRIDLSNNQIAEIAP-- 350
Cdd:cd21340  119 -SNSLR-------------VLNISG---------------------NNIDSLEP--LAPLRNLEQLDASNNQISDLEEll 161

                        250       260
                 ....*....|....*....|....
gi 12621130  351 DAFQGLRSLNSLVLYGNKITDLPR 374
Cdd:cd21340  162 DLLSSWPSLRELDLTGNPVCKKPK 185
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 282-308 1.35e-04

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 40.30  E-value: 1.35e-04
                           10        20
                   ....*....|....*....|....*..
gi 12621130    282 CPAMCSCSNGIVDCRGKGLTAIPANLP 308
Cdd:pfam01462    2 CPVPCHCSATVVNCSDRGLTAVPRDLP 28
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1087-1115 1.41e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 40.44  E-value: 1.41e-04
                           10        20
                   ....*....|....*....|....*....
gi 12621130   1087 CKDHQCQNGAQCVDEINSYACLCAEGYSG 1115
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTG 29
LRRNT smart00013
Leucine rich repeat N-terminal domain;
512-544 1.64e-04

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 40.38  E-value: 1.64e-04
                            10        20        30
                    ....*....|....*....|....*....|...
gi 12621130     512 ACPHKCRCEASVVECSGLKLSKIPERIPQSTTE 544
Cdd:smart00013    1 ACPAPCNCSGTAVDCSGRGLTEVPLDLPPDTTL 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
1005-1041 1.70e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.31  E-value: 1.70e-04
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 12621130    1005 NTDDCV-KHDCVNGGVCVDGIGNYTCQCPLQYT-GRACE 1041
Cdd:smart00179    1 DIDECAsGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
LRRNT smart00013
Leucine rich repeat N-terminal domain;
733-765 1.88e-04

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 39.99  E-value: 1.88e-04
                            10        20        30
                    ....*....|....*....|....*....|...
gi 12621130     733 QCPQECACLDTVVRCSNKHLQALPKGIPKNVTE 765
Cdd:smart00013    1 ACPAPCNCSGTAVDCSGRGLTEVPLDLPPDTTL 33
LRRCT smart00082
Leucine rich repeat C-terminal domain;
439-469 3.26e-04

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 39.72  E-value: 3.26e-04
                            10        20        30
                    ....*....|....*....|....*....|...
gi 12621130     439 NPFICDCNLKWLADFLRTNPI--ETTGARCASP 469
Cdd:smart00082    1 NPFICDCELRWLLRWLQANEHlqDPVDLRCASP 33
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1050-1079 5.40e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 38.90  E-value: 5.40e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 12621130   1050 DLNPCQHEAQCVGTPEGPRCECVPGYTGDN 1079
Cdd:pfam00008    2 APNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
1044-1080 8.86e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.38  E-value: 8.86e-04
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 12621130    1044 VDFCSPDlNPCQHEAQCVGTPEGPRCECVPGYT-GDNC 1080
Cdd:smart00179    2 IDECASG-NPCQNGGTCVNTVGSYRCECPPGYTdGRNC 38
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 733-760 2.18e-03

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 36.84  E-value: 2.18e-03
                           10        20
                   ....*....|....*....|....*...
gi 12621130    733 QCPQECACLDTVVRCSNKHLQALPKGIP 760
Cdd:pfam01462    1 ACPVPCHCSATVVNCSDRGLTAVPRDLP 28
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 929-960 2.18e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.98  E-value: 2.18e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 12621130    929 CLSSPCQNQGTCHNDPlEVYRCTCPSGYKGRN 960
Cdd:pfam00008    1 CAPNPCSNGGTCVDTP-GGYTCICPEGYTGKR 31
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 512-539 2.70e-03

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 36.84  E-value: 2.70e-03
                           10        20
                   ....*....|....*....|....*...
gi 12621130    512 ACPHKCRCEASVVECSGLKLSKIPERIP 539
Cdd:pfam01462    1 ACPVPCHCSATVVNCSDRGLTAVPRDLP 28
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1009-1038 3.02e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.59  E-value: 3.02e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 12621130   1009 CVKHDCVNGGVCVDGIGNYTCQCPLQYTGR 1038
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGK 30
 
Name Accession Description Interval E-value
LamG smart00282
Laminin G domain;
1186-1319 3.70e-38

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 139.40  E-value: 3.70e-38
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12621130    1186 NITLQVSTAEDNGILLYNG---DNDHIAVELYQGHVRVSYDPGSYPSSAIYSAETINDGQFHTVELVTFDQMVNLSIDGG 1262
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGskgGGDYLALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVERNGRSVTLSVDGG 80

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 12621130    1263 SPMTMDNFGKHYTLNSEAPLYVGGMPVDvnsaaFRLWQILNGTSFHGCIRNLYINNE 1319
Cdd:smart00282   81 NRVSGESPGGLTILNLDGPLYLGGLPED-----LKLPPLPVTPGFRGCIRNLKVNGK 132
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 1164-1317 3.92e-37

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 137.16  E-value: 3.92e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12621130 1164 SVNFvDRDTYLQFTDLQN-WPRANITLQVSTAEDNGILLYNGD---NDHIAVELYQGHVRVSYDPGSypSSAIYSAET-I 1238
Cdd:cd00110    1 GVSF-SGSSYVRLPTLPApRTRLSISFSFRTTSPNGLLLYAGSqngGDFLALELEDGRLVLRYDLGS--GSLVLSSKTpL 77

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 12621130 1239 NDGQFHTVELVTFDQMVNLSIDGGSPMTMDNFGKHYTLNSEAPLYVGGMPVDVnsaafRLWQILNGTSFHGCIRNLYIN 1317
Cdd:cd00110   78 NDGQWHSVSVERNGRSVTLSVDGERVVESGSPGGSALLNLDGPLYLGGLPEDL-----KSPGLPVSPGFVGCIRDLKVN 151
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 1191-1319 4.24e-34

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 127.54  E-value: 4.24e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12621130   1191 VSTAEDNGILLYNGD--NDHIAVELYQGHVRVSYDPGSYPSSAIYSAETINDGQFHTVELVTFDQMVNLSIDGGSPMTMD 1268
Cdd:pfam02210    1 FRTRQPNGLLLYAGGggSDFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVSSL 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 12621130   1269 NFGKHYTLNSEAPLYVGGMPVDVnsaafRLWQILNGTSFHGCIRNLYINNE 1319
Cdd:pfam02210   81 PPGESLLLNLNGPLYLGGLPPLL-----LLPALPVRAGFVGCIRDVRVNGE 126
Laminin_G_1 pfam00054
Laminin G domain;
1191-1322 1.71e-28

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 111.64  E-value: 1.71e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12621130   1191 VSTAEDNGILLYNGDNDH---IAVELYQGHVRVSYDPGSYPSSaIYSAETINDGQFHTVELVTFDQMVNLSIDGG-SPMT 1266
Cdd:pfam00054    1 FRTTEPSGLLLYNGTQTErdfLALELRDGRLEVSYDLGSGAAV-VRSGDKLNDGKWHSVELERNGRSGTLSVDGEaRPTG 79

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 12621130   1267 MDNFGKHYTLNSEAPLYVGGMPVDVNSAafrlWQILNGTSFHGCIRNLYINNELQD 1322
Cdd:pfam00054   80 ESPLGATTDLDVDGPLYVGGLPSLGVKK----RRLAISPSFDGCIRDVIVNGKPLD 131
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
43-217 1.85e-28

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 120.04  E-value: 1.85e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12621130   43 TTVDCHGTGLQAIPKNIPRNT--ERLELNGNNITRIHKnDFAGLKQLRVLQLMENQIGAVERgAFDDMKELERLRLNRNQ 120
Cdd:COG4886  116 ESLDLSGNQLTDLPEELANLTnlKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQ 193

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12621130  121 LQVLPELLfQNNQALSRLDLSENSLQAVPrKAFRGATDLKNLQLDKNQISCIEEgaFRALRGLEVLTLNNNNITTIPVSS 200
Cdd:COG4886  194 ITDLPEPL-GNLTNLEELDLSGNQLTDLP-EPLANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPPLA 269

                        170
                 ....*....|....*..
gi 12621130  201 fnHMPKLRTFRLHSNHL 217
Cdd:COG4886  270 --NLTNLKTLDLSNNQL 284
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
543-820 2.86e-23

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 104.63  E-value: 2.86e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12621130  543 TELRLNNNEisileatgLFKKLSHLKKINLSNNKVSEIEDgTFEGATSVSELHLTANQLESVRSGmFRGLDGLRTLMLRN 622
Cdd:COG4886   99 TELDLSGNE--------ELSNLTNLESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDLPEP-LGNLTNLKSLDLSN 168

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12621130  623 NRISCIhNDSFTGLRNVRLLSLYDNHITTIsPGAFDTLQALSTLNLlanpfncncqlawlgdwlrkrkivtgnprcqnpd 702
Cdd:COG4886  169 NQLTDL-PEELGNLTNLKELDLSNNQITDL-PEPLGNLTNLEELDL---------------------------------- 212

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12621130  703 flrqiplqdvafpdfrceegqeevgclprpqcpqecacldtvvrcSNKHLQALPKGIP--KNVTELYLDGNQFTLVPgQL 780
Cdd:COG4886  213 ---------------------------------------------SGNQLTDLPEPLAnlTNLETLDLSNNQLTDLP-EL 246

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 12621130  781 STFKYLQLVDLSNNKISSLSNSSftNMSQLTTLILSYNAL 820
Cdd:COG4886  247 GNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQL 284
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
55-477 4.68e-23

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 103.86  E-value: 4.68e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12621130   55 IPKNIPRNTERLELNGNNITRIHKNDFAGLKQLRVLQLMENQigavergAFDDMKELERLRLNRNQLQVLPELLfQNNQA 134
Cdd:COG4886   66 LLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGNQLTDLPEEL-ANLTN 137

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12621130  135 LSRLDLSENSLQAVPrKAFRGATDLKNLQLDKNQISCIEEgAFRALRGLEVLTLNNNNITTIPvSSFNHMPKLRTFRLHS 214
Cdd:COG4886  138 LKELDLSNNQLTDLP-EPLGNLTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDLP-EPLGNLTNLEELDLSG 214

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12621130  215 NHLFcdchlawlsqwlrqrpTIglftqcsgPASLRGLNvaevqksefscsgqgeaaqvpacTLSSgscpamcscsngiVD 294
Cdd:COG4886  215 NQLT----------------DL--------PEPLANLT-----------------------NLET-------------LD 234

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12621130  295 CRGKGLTAIP--ANLPEtMTEIRLELNGIKSIPPGAFSPyrKLRRIDLSNNQIAEIAPDAFQGLRSLNSLVLYGNKITDL 372
Cdd:COG4886  235 LSNNQLTDLPelGNLTN-LEELDLSNNQLTDLPPLANLT--NLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLL 311

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12621130  373 PrgVFGGLYTLQLLLLNANKINCIRPDAFQDLQNLSLLSLYDNKIQSLAKGTFTSLRAIQTLHLAQNPFICDCNLKWLAD 452
Cdd:COG4886  312 E--LLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTL 389

                        410       420
                 ....*....|....*....|....*
gi 12621130  453 FLRTNPIETTGARCASPRRLANKRI 477
Cdd:COG4886  390 LLLLLTTTAGVLLLTLALLDAVNTE 414
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
529-827 1.64e-22

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 102.32  E-value: 1.64e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12621130  529 LKLSKIPERIPQSTTELRLNNNEISILEATGLFKKLSHLKKINLSNNKVSEIEDGTFEGATSVSELHLTANQLesvrsgm 608
Cdd:COG4886   36 ALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEE------- 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12621130  609 FRGLDGLRTLMLRNNRISCIhNDSFTGLRNVRLLSLYDNHITTIsPGAFDTLQALSTLNLLANPfncncqlawlgdwlrk 688
Cdd:COG4886  109 LSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQ---------------- 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12621130  689 rkivtgnprcqnpdfLRQIPlqdvafpdfrceegqEEVGCLPRpqcpqecacLdTVVRCSNKHLQALPKGI--PKNVTEL 766
Cdd:COG4886  171 ---------------LTDLP---------------EELGNLTN---------L-KELDLSNNQITDLPEPLgnLTNLEEL 210

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 12621130  767 YLDGNQFTLVPGQLSTFKYLQLVDLSNNKISSLsnSSFTNMSQLTTLILSYNALQCIPPLA 827
Cdd:COG4886  211 DLSGNQLTDLPEPLANLTNLETLDLSNNQLTDL--PELGNLTNLEELDLSNNQLTDLPPLA 269
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
106-484 6.36e-21

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 97.31  E-value: 6.36e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12621130  106 DDMKELERLRLNRNQLQVLPELLFQNNQALSRLDLSENslqavprKAFRGATDLKNLQLDKNQISCIEEgAFRALRGLEV 185
Cdd:COG4886   69 LSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDLPE-ELANLTNLKE 140

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12621130  186 LTLNNNNITTIPvSSFNHMPKLRTFRLHSNHLfcdchlawlsqwlrqrptIGLftqcsgPASLRGLNvaevqksefscsg 265
Cdd:COG4886  141 LDLSNNQLTDLP-EPLGNLTNLKSLDLSNNQL------------------TDL------PEELGNLT------------- 182

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12621130  266 qgeaaqvpactlssgscpamcscsngivdcrgkgltaipaNLpetmTEIRLELNGIKSIPPgAFSPYRKLRRIDLSNNQI 345
Cdd:COG4886  183 ----------------------------------------NL----KELDLSNNQITDLPE-PLGNLTNLEELDLSGNQL 217

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12621130  346 AEIaPDAFQGLRSLNSLVLYGNKITDLPrgvfgglytlqllllnankincirpdAFQDLQNLSLLSLYDNKIQSLakGTF 425
Cdd:COG4886  218 TDL-PEPLANLTNLETLDLSNNQLTDLP--------------------------ELGNLTNLEELDLSNNQLTDL--PPL 268

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 12621130  426 TSLRAIQTLHLAQNPfICDCNLKWLADFLRTNPIETTGARCASPRRLANKRIGQIKSKK 484
Cdd:COG4886  269 ANLTNLKTLDLSNNQ-LTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLL 326
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
543-826 2.65e-20

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 95.39  E-value: 2.65e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12621130  543 TELRLNNNEISILEATglFKKLSHLKKINLSNNKVSEIEDgTFEGATSVSELHLTANQLESVRSGmFRGLDGLRTLMLRN 622
Cdd:COG4886  116 ESLDLSGNQLTDLPEE--LANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPEE-LGNLTNLKELDLSN 191

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12621130  623 NRISCIHnDSFTGLRNVRLLSLYDNHITTIsPGAFDTLQALSTLNLLANPfncncqlawlgdwlrkrkivtgnprcqnpd 702
Cdd:COG4886  192 NQITDLP-EPLGNLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQ------------------------------ 239

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12621130  703 fLRQIPlqdvafpdfrceegqeEVGCLPrpqcpqecacldtvvrcsnkhlqalpkgipkNVTELYLDGNQFTLVPgQLST 782
Cdd:COG4886  240 -LTDLP----------------ELGNLT-------------------------------NLEELDLSNNQLTDLP-PLAN 270

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 12621130  783 FKYLQLVDLSNNKISSLSNSSFTNMSQLTTLILSYNALQCIPPL 826
Cdd:COG4886  271 LTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELL 314
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
303-679 3.85e-20

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 95.00  E-value: 3.85e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12621130  303 IPANLPETMTEIRLELNGIKSIPPGAFSPYRKLRRIDLSNNqiaeiapDAFQGLRSLNSLVLYGNKITDLPrgvfgglyt 382
Cdd:COG4886   66 LLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDLP--------- 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12621130  383 lqllllnankincirpDAFQDLQNLSLLSLYDNKIQSLAKgTFTSLRAIQTLHLAQNpficdcnlkwladflrtnpiett 462
Cdd:COG4886  130 ----------------EELANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNN----------------------- 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12621130  463 garcasprrlankrigqikskkfrcsakeqyfipgtedyhlnsectsdvacphkcrceasvvecsglKLSKIPERIPQST 542
Cdd:COG4886  170 -------------------------------------------------------------------QLTDLPEELGNLT 182

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12621130  543 --TELRLNNNEISILEATglFKKLSHLKKINLSNNKVSEIEDgTFEGATSVSELHLTANQLESVRSgmFRGLDGLRTLML 620
Cdd:COG4886  183 nlKELDLSNNQITDLPEP--LGNLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDL 257

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 12621130  621 RNNRISCIhnDSFTGLRNVRLLSLYDNHITTISPGAFDTLQALSTLNLLANPFNCNCQL 679
Cdd:COG4886  258 SNNQLTDL--PPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELL 314
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
312-674 2.70e-19

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 92.30  E-value: 2.70e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12621130  312 TEIRLELNGIKSIPPgAFSPYRKLRRIDLSNNQIAEIaPDAFQGLRSLNSLVLYGNKITDLPrgvfgglytlqllllnan 391
Cdd:COG4886  116 ESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDLP------------------ 175

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12621130  392 kincirpDAFQDLQNLSLLSLYDNKIQSLAKgTFTSLRAIQTLHLAQNpficdcnlkwladflrtnpiettgarcasprr 471
Cdd:COG4886  176 -------EELGNLTNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGN-------------------------------- 215

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12621130  472 lankrigqikskkfrcsakeqyfipgtedyhlnsectsdvacphkcrceasvvecsglKLSKIPERIPQST--TELRLNN 549
Cdd:COG4886  216 ----------------------------------------------------------QLTDLPEPLANLTnlETLDLSN 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12621130  550 NEISILEAtglFKKLSHLKKINLSNNKVSEIEDgtFEGATSVSELHLTANQLESVR----SGMFRGLDGLRTLMLRNNRI 625
Cdd:COG4886  238 NQLTDLPE---LGNLTNLEELDLSNNQLTDLPP--LANLTNLKTLDLSNNQLTDLKlkelELLLGLNSLLLLLLLLNLLE 312

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*....
gi 12621130  626 SCIHNDSFTGLRNVRLLSLYDNHITTISPGAFDTLQALSTLNLLANPFN 674
Cdd:COG4886  313 LLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSL 361
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
315-674 3.12e-19

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 92.30  E-value: 3.12e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12621130  315 RLELNGIKSIppgafSPYRKLRRIDLSNNQIAEIaPDAFQGLRSLNSLVLYGNKITDLprgvfgglytlqllllnankin 394
Cdd:COG4886  100 ELDLSGNEEL-----SNLTNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDL---------------------- 151

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12621130  395 cirPDAFQDLQNLSLLSLYDNKIQSLAKgtftslrAIQTLHlaqnpficdcNLKWLadFLRTNPIETtgarcasprrlan 474
Cdd:COG4886  152 ---PEPLGNLTNLKSLDLSNNQLTDLPE-------ELGNLT----------NLKEL--DLSNNQITD------------- 196

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12621130  475 krigqikskkfrcsakeqyfIPgtedyhlnsectsdvacphkcrceASVVECSGLKlskiperipqsttELRLNNNEISI 554
Cdd:COG4886  197 --------------------LP------------------------EPLGNLTNLE-------------ELDLSGNQLTD 219

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12621130  555 LEATglFKKLSHLKKINLSNNKVSEIEDgtFEGATSVSELHLTANQLESVRSGMfrGLDGLRTLMLRNNRISCIHNDSFT 634
Cdd:COG4886  220 LPEP--LANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQLTDLKLKELE 293

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|
gi 12621130  635 GLRNVRLLSLYDNHITTISPGAFDTLQALSTLNLLANPFN 674
Cdd:COG4886  294 LLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGL 333
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
43-198 3.39e-18

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 88.84  E-value: 3.39e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12621130   43 TTVDCHGTGLQAIPKNIPR--NTERLELNGNNITRIHKnDFAGLKQLRVLQLMENQIGAVERgAFDDMKELERLRLNRNQ 120
Cdd:COG4886  162 KSLDLSNNQLTDLPEELGNltNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQ 239

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 12621130  121 LQVLPELlfQNNQALSRLDLSENSLQAVPrkAFRGATDLKNLQLDKNQISCIEEGAFRALRGLEVLTLNNNNITTIPV 198
Cdd:COG4886  240 LTDLPEL--GNLTNLEELDLSNNQLTDLP--PLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLEL 313
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
743-868 4.60e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 79.21  E-value: 4.60e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12621130  743 TVVRCSNKHLQALPKGIP--KNVTELYLDGNQFTLVPGQLSTFKYLQLVDLSNNKISSLSnSSFTNMSQLTTLILSYNAL 820
Cdd:COG4886  116 ESLDLSGNQLTDLPEELAnlTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLP-EELGNLTNLKELDLSNNQI 194

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 12621130  821 QCIPPlAFQGLRSLRLLSLHGNDVSTLQEGIfADVTSLSHLAIGANPL 868
Cdd:COG4886  195 TDLPE-PLGNLTNLEELDLSGNQLTDLPEPL-ANLTNLETLDLSNNQL 240
LRR_8 pfam13855
Leucine rich repeat;
589-649 1.16e-13

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 66.78  E-value: 1.16e-13
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 12621130    589 TSVSELHLTANQLESVRSGMFRGLDGLRTLMLRNNRISCIHNDSFTGLRNVRLLSLYDNHI 649
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
614-673 3.46e-13

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 65.62  E-value: 3.46e-13
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 12621130    614 GLRTLMLRNNRISCIHNDSFTGLRNVRLLSLYDNHITTISPGAFDTLQALSTLNLLANPF 673
Cdd:pfam13855    2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 644-730 5.01e-13

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 74.73  E-value: 5.01e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12621130    644 LYDNHITTISPGAFDTLQALSTLNLLANPFNCNCQLAWLGDWLRKRKIVTGNPR---CQNPDFLRQIPLQDVAFPDFRCe 720
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVRQPEaalCAGPGALAGQPLLGIPLLDSGC- 80

                           90
                   ....*....|
gi 12621130    721 eGQEEVGCLP 730
Cdd:TIGR00864   81 -DEEYVACLK 89
LRR_8 pfam13855
Leucine rich repeat;
159-217 2.17e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 63.31  E-value: 2.17e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 12621130    159 LKNLQLDKNQISCIEEGAFRALRGLEVLTLNNNNITTIPVSSFNHMPKLRTFRLHSNHL 217
Cdd:pfam13855    3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
135-193 1.04e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 61.39  E-value: 1.04e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 12621130    135 LSRLDLSENSLQAVPRKAFRGATDLKNLQLDKNQISCIEEGAFRALRGLEVLTLNNNNI 193
Cdd:pfam13855    3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
565-625 1.14e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 61.39  E-value: 1.14e-11
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 12621130    565 SHLKKINLSNNKVSEIEDGTFEGATSVSELHLTANQLESVRSGMFRGLDGLRTLMLRNNRI 625
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
312-369 2.18e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 60.62  E-value: 2.18e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 12621130    312 TEIRLELNGIKSIPPGAFSPYRKLRRIDLSNNQIAEIAPDAFQGLRSLNSLVLYGNKI 369
Cdd:pfam13855    4 RSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
736-868 3.23e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 67.27  E-value: 3.23e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12621130  736 QECACLDTVVRCSNKHLQALpkgipKNVTELYLDGNQFTLVPGQLSTFKYLQLVDLSNNKISSLSnSSFTNMSQLTTLIL 815
Cdd:COG4886   93 GDLTNLTELDLSGNEELSNL-----TNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLP-EPLGNLTNLKSLDL 166

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 12621130  816 SYNALQCIPPlAFQGLRSLRLLSLHGNDVSTLQEGIfADVTSLSHLAIGANPL 868
Cdd:COG4886  167 SNNQLTDLPE-ELGNLTNLKELDLSNNQITDLPEPL-GNLTNLEELDLSGNQL 217
LRR_8 pfam13855
Leucine rich repeat;
61-121 5.09e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 59.46  E-value: 5.09e-11
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 12621130     61 RNTERLELNGNNITRIHKNDFAGLKQLRVLQLMENQIGAVERGAFDDMKELERLRLNRNQL 121
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 530-673 8.97e-11

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 63.27  E-value: 8.97e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12621130  530 KLSKIpERIPQST--TELRLNNNEISILEatGLfKKLSHLKKINLSNNKVSEIEDgtFEGATSVSELHLTANQLES---- 603
Cdd:cd21340   35 KITKI-ENLEFLTnlTHLYLQNNQIEKIE--NL-ENLVNLKKLYLGGNRISVVEG--LENLTNLEELHIENQRLPPgekl 108

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 12621130  604 ---VRSgMFRGLDGLRTLMLRNNRISCIhnDSFTGLRNVRLLSLYDNHITTISP--GAFDTLQALSTLNLLANPF 673
Cdd:cd21340  109 tfdPRS-LAALSNSLRVLNISGNNIDSL--EPLAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGNPV 180
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 66-217 1.06e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 63.27  E-value: 1.06e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12621130   66 LELNGNNITRIhkNDFAGLKQLRVLQLMENQIGAVErgAFDDMKELERLRLNRNQLQVLPELlfQNNQALSRLDLSENSL 145
Cdd:cd21340    7 LYLNDKNITKI--DNLSLCKNLKVLYLYDNKITKIE--NLEFLTNLTHLYLQNNQIEKIENL--ENLVNLKKLYLGGNRI 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 12621130  146 QAVprKAFRGATDLKNLQLDKNQIS-----CIEEGAFRALRG-LEVLTLNNNNITTIpvSSFNHMPKLRTFRLHSNHL 217
Cdd:cd21340   81 SVV--EGLENLTNLEELHIENQRLPpgeklTFDPRSLAALSNsLRVLNISGNNIDSL--EPLAPLRNLEQLDASNNQI 154
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 842-1002 1.35e-10

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 66.64  E-value: 1.35e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12621130    842 NDVSTLQEGIFADVTSLSHLAIGANPLYCDCHLRWLSSWVK---TGYKEPGIARCAGPPEMEGKLLLTTPAKKFECqGPP 918
Cdd:TIGR00864    5 NKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEekgVKVRQPEAALCAGPGALAGQPLLGIPLLDSGC-DEE 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12621130    919 SLAvqakCDPCLSSpcqnQGTCHNDPLEVYRCTCPSGYKGRNCEVSLDSCSSNPCGNGGT----CHAQEGEDAGFT---- 990
Cdd:TIGR00864   84 YVA----CLKDNSS----GGGAARSELVIFSAAHEGLFQPEACNAFCFSAGHGLAALGEQgeclCGAAQPSEANFAcesl 155

                          170
                   ....*....|..
gi 12621130    991 CSCPSGFEGLTC 1002
Cdd:TIGR00864  156 CSGPPPPPAAAC 167
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
529-818 1.48e-10

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 65.87  E-value: 1.48e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12621130   529 LKLSKIPERIPQSTTELRLNNNEISILEATglfkKLSHLKKINLSNNKVSEIEDGTfegATSVSELHLTANQLESVRSgm 608
Cdd:PRK15370  188 LGLTTIPACIPEQITTLILDNNELKSLPEN----LQGNIKTLYANSNQLTSIPATL---PDTIQEMELSINRITELPE-- 258

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12621130   609 fRGLDGLRTLMLRNNRISCIHNDSFTGLRNvrlLSLYDNHITTIsPGAFDTlqALSTLNLLANpfncncQLAWLGDWLrk 688
Cdd:PRK15370  259 -RLPSALQSLDLFHNKISCLPENLPEELRY---LSVYDNSIRTL-PAHLPS--GITHLNVQSN------SLTALPETL-- 323

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12621130   689 rkivtgnprcqnPDFLRQIplqdvafpdfrcEEGQEEVGCLPRpQCPQECACLDTvvrcSNKHLQALPKGIPKNVTELYL 768
Cdd:PRK15370  324 ------------PPGLKTL------------EAGENALTSLPA-SLPPELQVLDV----SKNQITVLPETLPPTITTLDV 374

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 12621130   769 DGNQFTLVPGQLSTfkYLQLVDLSNNKISSLSNS--SFTNMS-QLTTLILSYN 818
Cdd:PRK15370  375 SRNALTNLPENLPA--ALQIMQASRNNLVRLPESlpHFRGEGpQPTRIIVEYN 425
LRR_8 pfam13855
Leucine rich repeat;
333-417 6.16e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 56.38  E-value: 6.16e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12621130    333 RKLRRIDLSNNQIAEIAPDAFQGLRSLNSLVLYGNKITdlprgvfgglytlqllllnankinCIRPDAFQDLQNLSLLSL 412
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLT------------------------TLSPGAFSGLPSLRYLDL 56


                   ....*
gi 12621130    413 YDNKI 417
Cdd:pfam13855   57 SGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
543-601 8.26e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 55.99  E-value: 8.26e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 12621130    543 TELRLNNNEISILEAtGLFKKLSHLKKINLSNNKVSEIEDGTFEGATSVSELHLTANQL 601
Cdd:pfam13855    4 RSLDLSNNRLTSLDD-GAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 43-217 1.73e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 59.41  E-value: 1.73e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12621130   43 TTVDCHGTGLQAIPK-NIPRNTERLELNGNNITRIhkNDFAGLKQLRVLQLMENQIGAVERgaFDDMKELERLRLNRNQL 121
Cdd:cd21340    5 THLYLNDKNITKIDNlSLCKNLKVLYLYDNKITKI--ENLEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12621130  122 QV------LPEL--LFQNNQALSR---LDLSENSLQAVprkafrgATDLKNLQLDKNQISCIEEgaFRALRGLEVLTLNN 190
Cdd:cd21340   81 SVveglenLTNLeeLHIENQRLPPgekLTFDPRSLAAL-------SNSLRVLNISGNNIDSLEP--LAPLRNLEQLDASN 151

                        170       180
                 ....*....|....*....|....*....
gi 12621130  191 NNITTIP--VSSFNHMPKLRTFRLHSNHL 217
Cdd:cd21340  152 NQISDLEelLDLLSSWPSLRELDLTGNPV 180
LRR_8 pfam13855
Leucine rich repeat;
110-169 1.77e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 55.22  E-value: 1.77e-09
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 12621130    110 ELERLRLNRNQLQVLPELLFQNNQALSRLDLSENSLQAVPRKAFRGATDLKNLQLDKNQI 169
Cdd:pfam13855    2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
762-820 2.11e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 54.84  E-value: 2.11e-09
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 12621130    762 NVTELYLDGNQFTLV-PGQLSTFKYLQLVDLSNNKISSLSNSSFTNMSQLTTLILSYNAL 820
Cdd:pfam13855    2 NLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
28-197 3.66e-09

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 61.64  E-value: 3.66e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12621130    28 RLGATACPALCTCTGTTVDCHGTGLQAIPKNIPRNTERLELNGNNITRI-------------HKNDFAGLKQ-----LRV 89
Cdd:PRK15370  187 ILGLTTIPACIPEQITTLILDNNELKSLPENLQGNIKTLYANSNQLTSIpatlpdtiqemelSINRITELPErlpsaLQS 266

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12621130    90 LQLMENQIGAVERGAFDdmkELERLRLNRNQLQVLPELLfqnNQALSRLDLSENSLQAVPRKAFRGatdLKNLQLDKNQI 169
Cdd:PRK15370  267 LDLFHNKISCLPENLPE---ELRYLSVYDNSIRTLPAHL---PSGITHLNVQSNSLTALPETLPPG---LKTLEAGENAL 337

                         170       180
                  ....*....|....*....|....*...
gi 12621130   170 SCIEEGAFRALRgleVLTLNNNNITTIP 197
Cdd:PRK15370  338 TSLPASLPPELQ---VLDVSKNQITVLP 362
LRR_8 pfam13855
Leucine rich repeat;
389-441 6.91e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 53.30  E-value: 6.91e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 12621130    389 NANKINCIRPDAFQDLQNLSLLSLYDNKIQSLAKGTFTSLRAIQTLHLAQNPF 441
Cdd:pfam13855    9 SNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 55-217 2.58e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 58.71  E-value: 2.58e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12621130    55 IPKNIP--RNTERLELNGNNITRIHKNDFAGLKQLRVLQLMENQI-GAVERGAFDdMKELERLRLNRNQ-LQVLPELLFQ 130
Cdd:PLN00113  396 IPKSLGacRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLqGRINSRKWD-MPSLQMLSLARNKfFGGLPDSFGS 474

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12621130   131 NNqaLSRLDLSENSLQ-AVPRKaFRGATDLKNLQLDKNQISCIEEGAFRALRGLEVLTLNNNNIT-TIPvSSFNHMPKLR 208
Cdd:PLN00113  475 KR--LENLDLSRNQFSgAVPRK-LGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSgQIP-ASFSEMPVLS 550


                  ....*....
gi 12621130   209 TFRLHSNHL 217
Cdd:PLN00113  551 QLDLSQNQL 559
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 131-671 4.67e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 57.94  E-value: 4.67e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12621130   131 NNQALSRLDLSENSLQAVPRKAFRGATDLKNLQLDKNQISC-IEEGAFRALRGLEVLTLNNNNIT-TIPVSSfnhMPKLR 208
Cdd:PLN00113   67 NSSRVVSIDLSGKNISGKISSAIFRLPYIQTINLSNNQLSGpIPDDIFTTSSSLRYLNLSNNNFTgSIPRGS---IPNLE 143

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12621130   209 TFRLHSNHLFCDCHLawlsqwlrqrpTIGLFTqcsgpaSLRGLNVAevqksefscsGQGEAAQVPACTLSSGSCPAMCSC 288
Cdd:PLN00113  144 TLDLSNNMLSGEIPN-----------DIGSFS------SLKVLDLG----------GNVLVGKIPNSLTNLTSLEFLTLA 196

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12621130   289 SNGIVDcrgkgltAIPANLPE--TMTEIRLELNGIKSIPPGAFSPYRKLRRIDLSNNQIAEIAPDAFQGLRSLNSLVLYG 366
Cdd:PLN00113  197 SNQLVG-------QIPRELGQmkSLKWIYLGYNNLSGEIPYEIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQ 269

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12621130   367 NKITD-LPRGVFGgLYTLQLLLLNANKINCIRPDAFQDLQNLSLLSLYDNKIQSLAKGTFTSLRAIQTLHLAQNPFICDC 445
Cdd:PLN00113  270 NKLSGpIPPSIFS-LQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFSGEI 348

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12621130   446 --------NLKWLAdfLRTNPI--ETTGARCASPR-----RLANKRIGQIKSKKFRCSAKEQYFIpgtEDYHLNSECTSD 510
Cdd:PLN00113  349 pknlgkhnNLTVLD--LSTNNLtgEIPEGLCSSGNlfkliLFSNSLEGEIPKSLGACRSLRRVRL---QDNSFSGELPSE 423

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12621130   511 vacphkcrceasvvecsglkLSKIPeripqSTTELRLNNNEISILEATGLFkKLSHLKKINLSNNKVS-EIEDgtFEGAT 589
Cdd:PLN00113  424 --------------------FTKLP-----LVYFLDISNNNLQGRINSRKW-DMPSLQMLSLARNKFFgGLPD--SFGSK 475

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12621130   590 SVSELHLTANQLESVRSGMFRGLDGLRTLMLRNNRISCIHNDSFTGLRNVRLLSLYDNHITTISPGAFDTLQALSTLNLL 669
Cdd:PLN00113  476 RLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLS 555


                  ..
gi 12621130   670 AN 671
Cdd:PLN00113  556 QN 557
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 188-328 5.01e-08

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 58.17  E-value: 5.01e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12621130    188 LNNNNITTIPVSSFNHMPKLRTFRLHSNHLFCDCHLAWLSQWLRQ------RPTIglfTQCSGPASLRGLNVAEVQKSEF 261
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEkgvkvrQPEA---ALCAGPGALAGQPLLGIPLLDS 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12621130    262 SC----------SGQGEAAQVPACTLSSGS---------CPAMC-SCSNGIVDCRGKGLTAIPANLPETMTEIRLELNGI 321
Cdd:TIGR00864   79 GCdeeyvaclkdNSSGGGAARSELVIFSAAheglfqpeaCNAFCfSAGHGLAALGEQGECLCGAAQPSEANFACESLCSG 158


                   ....*..
gi 12621130    322 KSIPPGA 328
Cdd:TIGR00864  159 PPPPPAA 165
LRR_8 pfam13855
Leucine rich repeat;
786-832 5.90e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.60  E-value: 5.90e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 12621130    786 LQLVDLSNNKISSLSNSSFTNMSQLTTLILSYNALQCIPPLAFQGLR 832
Cdd:pfam13855    3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLP 49
LRR_8 pfam13855
Leucine rich repeat;
86-145 6.01e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.60  E-value: 6.01e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 12621130     86 QLRVLQLMENQIGAVERGAFDDMKELERLRLNRNQLQVLPELLFQNNQALSRLDLSENSL 145
Cdd:pfam13855    2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRRCT smart00082
Leucine rich repeat C-terminal domain;
866-915 5.67e-07

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 47.81  E-value: 5.67e-07
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 12621130     866 NPLYCDCHLRWLSSWV--KTGYKEPGIARCAGPPEMEGKLLLTTPAkKFECQ 915
Cdd:smart00082    1 NPFICDCELRWLLRWLqaNEHLQDPVDLRCASPSSLRGPLLELLHS-EFKCP 51
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
749-868 9.93e-07

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 53.55  E-value: 9.93e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12621130   749 NKHLQALPKGIPKNVTELYLDGNQFTLVPGQLStfKYLQLVDLSNNKISSLSNSSftnMSQLTTLILSYNALQCIP---P 825
Cdd:PRK15370  208 NNELKSLPENLQGNIKTLYANSNQLTSIPATLP--DTIQEMELSINRITELPERL---PSALQSLDLFHNKISCLPenlP 282

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 12621130   826 LAFQglrslrLLSLHGNDVSTLQEGIfadVTSLSHLAIGANPL 868
Cdd:PRK15370  283 EELR------YLSVYDNSIRTLPAHL---PSGITHLNVQSNSL 316
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 543-701 1.56e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 50.94  E-value: 1.56e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12621130  543 TELRLNNNEISILEATGLFKKLSHLKkinLSNNKVSEIEDgtFEGATSVSELHLTANQLESVRsgMFRGLDGLRTLMLRN 622
Cdd:cd21340    5 THLYLNDKNITKIDNLSLCKNLKVLY---LYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIE--NLENLVNLKKLYLGG 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12621130  623 NRISCIHN---------------------------DSFTGLRN-VRLLSLYDNHITTISPgaFDTLQALSTLNLLANPFN 674
Cdd:cd21340   78 NRISVVEGlenltnleelhienqrlppgekltfdpRSLAALSNsLRVLNISGNNIDSLEP--LAPLRNLEQLDASNNQIS 155

                        170       180
                 ....*....|....*....|....*....
gi 12621130  675 CNCQLAW-LGDWLRKRKI-VTGNPRCQNP 701
Cdd:cd21340  156 DLEELLDlLSSWPSLRELdLTGNPVCKKP 184
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1085-1119 2.08e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.71  E-value: 2.08e-06
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 12621130 1085 DDCKD-HQCQNGAQCVDEINSYACLCAEGYSGQLCE 1119
Cdd:cd00054    3 DECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 61-439 4.41e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 51.39  E-value: 4.41e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12621130    61 RNTERLELNGNNITRIHKNDFAGLKQLRVLQLMENQIGAVERGAFDDMKELERLRLNRNQLQ-VLPELLFqNNQALSRLD 139
Cdd:PLN00113  212 KSLKWIYLGYNNLSGEIPYEIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSgPIPPSIF-SLQKLISLD 290

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12621130   140 LSENSLQA-VPRKAFRgatdlknlqldknqiscieegafraLRGLEVLTLNNNNIT-TIPVSsFNHMPKLRTFRLHSNHL 217
Cdd:PLN00113  291 LSDNSLSGeIPELVIQ-------------------------LQNLEILHLFSNNFTgKIPVA-LTSLPRLQVLQLWSNKF 344

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12621130   218 fcdchlawlsqwlrqrptiglftqcSG--PASL-RGLNVAEVQKSEFSCSGQgeaaqVPACTLSSGSCPAMCSCSNGIVD 294
Cdd:PLN00113  345 -------------------------SGeiPKNLgKHNNLTVLDLSTNNLTGE-----IPEGLCSSGNLFKLILFSNSLEG 394

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12621130   295 CRGKGLTAIpanlpETMTEIRLELNGIKSIPPGAFSPYRKLRRIDLSNN----------------QIAEIA--------P 350
Cdd:PLN00113  395 EIPKSLGAC-----RSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNnlqgrinsrkwdmpslQMLSLArnkffgglP 469

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12621130   351 DAFqGLRSLNSLVLYGNKITD-LPRGvFGGLYTLQLLLLNANKINCIRPDAFQDLQNLSLLSLYDNKIQSLAKGTFTSLR 429
Cdd:PLN00113  470 DSF-GSKRLENLDLSRNQFSGaVPRK-LGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMP 547

                         410
                  ....*....|
gi 12621130   430 AIQTLHLAQN 439
Cdd:PLN00113  548 VLSQLDLSQN 557
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1005-1041 4.51e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.55  E-value: 4.51e-06
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 12621130 1005 NTDDCV-KHDCVNGGVCVDGIGNYTCQCPLQYTGRACE 1041
Cdd:cd00054    1 DIDECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 87-275 6.20e-06

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 50.05  E-value: 6.20e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12621130   87 LRVLQLMENQIGA-----VERGAFDDMKELERLRLNRNQLQVLP----ELLFQNNQALSRLDLSENSL--QAVPR--KAF 153
Cdd:cd00116  110 LQELKLNNNGLGDrglrlLAKGLKDLPPALEKLVLGRNRLEGAScealAKALRANRDLKELNLANNGIgdAGIRAlaEGL 189

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12621130  154 RGATDLKNLQLDKNQISCIE----EGAFRALRGLEVLTLNNNNITTIPVSSF-----NHMPKLRTFRLHSNHLFCDCHLA 224
Cdd:cd00116  190 KANCNLEVLDLNNNGLTDEGasalAETLASLKSLEVLNLGDNNLTDAGAAALasallSPNISLLTLSLSCNDITDDGAKD 269

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 12621130  225 wLSQWLRQRPTiglftqcsgpaslrgLNVAEVQKSEFSCSGQGEAAQVPAC 275
Cdd:cd00116  270 -LAEVLAEKES---------------LLELDLRGNKFGEEGAQLLAESLLE 304
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
299-420 6.38e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 50.85  E-value: 6.38e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12621130   299 GLTAIPANLPETMTEIRLELNGIKSIPPGAFSPYRKLRRIDLSNNQIAEIAPDAFQGLRslnslvLYGNKITDLPRGVfg 378
Cdd:PRK15370  189 GLTTIPACIPEQITTLILDNNELKSLPENLQGNIKTLYANSNQLTSIPATLPDTIQEME------LSINRITELPERL-- 260

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 12621130   379 gLYTLQLLLLNANKINCIrPDAFQDlqNLSLLSLYDNKIQSL 420
Cdd:PRK15370  261 -PSALQSLDLFHNKISCL-PENLPE--ELRYLSVYDNSIRTL 298
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1044-1080 6.94e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.16  E-value: 6.94e-06
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 12621130 1044 VDFCSPDlNPCQHEAQCVGTPEGPRCECVPGYTGDNC 1080
Cdd:cd00054    2 IDECASG-NPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 743-823 7.04e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 49.01  E-value: 7.04e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12621130  743 TVVRCSNKHLQALPK-GIPKNVTELYLDGNQFTLVPGqLSTFKYLQLVDLSNNKISSLSNssFTNMSQLTTLILSYNALQ 821
Cdd:cd21340    5 THLYLNDKNITKIDNlSLCKNLKVLYLYDNKITKIEN-LEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRIS 81


                 ..
gi 12621130  822 CI 823
Cdd:cd21340   82 VV 83
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 927-962 8.96e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.78  E-value: 8.96e-06
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 12621130  927 DPCLS-SPCQNQGTCHNDPlEVYRCTCPSGYKGRNCE 962
Cdd:cd00054    3 DECASgNPCQNGGTCVNTV-GSYRCSCPPGYTGRNCE 38
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 50-217 9.62e-06

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 49.79  E-value: 9.62e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12621130   50 TGLQAIPKNIPRNTE--RLELNGNNITRIHKNDFA----GLKQLRVLQLMENQIGavERGA---FDDMKE---LERLRLN 117
Cdd:COG5238  195 EGIEELAEALTQNTTvtTLWLKRNPIGDEGAEILAealkGNKSLTTLDLSNNQIG--DEGVialAEALKNnttVETLYLS 272

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12621130  118 RNQLQV-----LPELLfQNNQALSRLDLSENSLQAVPRKAF----RGATDLKNLQLDKNQISciEEGA---FRAL---RG 182
Cdd:COG5238  273 GNQIGAegaiaLAKAL-QGNTTLTSLDLSVNRIGDEGAIALaeglQGNKTLHTLNLAYNGIG--AQGAialAKALqenTT 349

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 12621130  183 LEVLTLNNNNITTIPVSSFNHMPKLRTfRLHSNHL 217
Cdd:COG5238  350 LHSLDLSDNQIGDEGAIALAKYLEGNT-TLRELNL 383
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 966-1002 1.10e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.78  E-value: 1.10e-05
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 12621130  966 DSCSS-NPCGNGGTCHAQEGedaGFTCSCPSGFEGLTC 1002
Cdd:cd00054    3 DECASgNPCQNGGTCVNTVG---SYRCSCPPGYTGRNC 37
LRRNT smart00013
Leucine rich repeat N-terminal domain;
33-64 1.28e-05

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 43.46  E-value: 1.28e-05
                            10        20        30
                    ....*....|....*....|....*....|..
gi 12621130      33 ACPALCTCTGTTVDCHGTGLQAIPKNIPRNTE 64
Cdd:smart00013    1 ACPAPCNCSGTAVDCSGRGLTEVPLDLPPDTT 32
LRRCT smart00082
Leucine rich repeat C-terminal domain;
671-719 1.55e-05

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 43.57  E-value: 1.55e-05
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|.
gi 12621130     671 NPFNCNCQLAWLGDWLRKRKIV--TGNPRCQNPDFLRQiPLQDVAFPDFRC 719
Cdd:smart00082    1 NPFICDCELRWLLRWLQANEHLqdPVDLRCASPSSLRG-PLLELLHSEFKC 50
LRR_8 pfam13855
Leucine rich repeat;
181-217 2.22e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 43.28  E-value: 2.22e-05
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 12621130    181 RGLEVLTLNNNNITTIPVSSFNHMPKLRTFRLHSNHL 217
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLL 37
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
296-373 2.48e-05

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 48.92  E-value: 2.48e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12621130   296 RGKGLTAIPANLPETMTEIRLELNGIKSIP---PGAfspyrkLRRIDLSNNQIAEIAPDAFQGLRSLNslvLYGNKITDL 372
Cdd:PRK15370  228 NSNQLTSIPATLPDTIQEMELSINRITELPerlPSA------LQSLDLFHNKISCLPENLPEELRYLS---VYDNSIRTL 298


                  .
gi 12621130   373 P 373
Cdd:PRK15370  299 P 299
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 412-475 2.59e-05

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 49.31  E-value: 2.59e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 12621130    412 LYDNKIQSLAKGTFTSLRAIQTLHLAQNPFICDCNLKWLADFLRTNPIETT---GARCASPRRLANK 475
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVRqpeAALCAGPGALAGQ 68
EGF_CA smart00179
Calcium-binding EGF-like domain;
1085-1119 4.69e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.85  E-value: 4.69e-05
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 12621130    1085 DDCK-DHQCQNGAQCVDEINSYACLCAEGYS-GQLCE 1119
Cdd:smart00179    3 DECAsGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
LRRNT smart00013
Leucine rich repeat N-terminal domain;
282-313 6.63e-05

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 41.15  E-value: 6.63e-05
                            10        20        30
                    ....*....|....*....|....*....|..
gi 12621130     282 CPAMCSCSNGIVDCRGKGLTAIPANLPETMTE 313
Cdd:smart00013    2 CPAPCNCSGTAVDCSGRGLTEVPLDLPPDTTL 33
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 114-374 7.93e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 45.55  E-value: 7.93e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12621130  114 LRLNRNQLQVLPEL-LFQNnqaLSRLDLSENSLQAVPrkAFRGATDLKNLQLDKNQISCIEEgaFRALRGLEVLTLNNNN 192
Cdd:cd21340    7 LYLNDKNITKIDNLsLCKN---LKVLYLYDNKITKIE--NLEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNR 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12621130  193 ITTipVSSFNHMPKLRTfrLHsnhlfcdchlawLSqwlRQRPTIGlFTQCSGPASLRGLnvaevqksefscsgqgeaaqv 272
Cdd:cd21340   80 ISV--VEGLENLTNLEE--LH------------IE---NQRLPPG-EKLTFDPRSLAAL--------------------- 118

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12621130  273 pACTLSsgscpamcscsngIVDCRGkgltaipanlpetmteirlelNGIKSIPPgaFSPYRKLRRIDLSNNQIAEIAP-- 350
Cdd:cd21340  119 -SNSLR-------------VLNISG---------------------NNIDSLEP--LAPLRNLEQLDASNNQISDLEEll 161

                        250       260
                 ....*....|....*....|....
gi 12621130  351 DAFQGLRSLNSLVLYGNKITDLPR 374
Cdd:cd21340  162 DLLSSWPSLRELDLTGNPVCKKPK 185
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 561-818 1.05e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 45.16  E-value: 1.05e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12621130  561 FKKLSHLkkiNLSNNKVSEIEDgtfegatsvseLHLTANqlesvrsgmfrgldgLRTLMLRNNRISCIHNdsFTGLRNVR 640
Cdd:cd21340    1 LKRITHL---YLNDKNITKIDN-----------LSLCKN---------------LKVLYLYDNKITKIEN--LEFLTNLT 49

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12621130  641 LLSLYDNHITTISPgaFDTLQALSTLNLlanpfNCNCqlawlgdwlrkrkI--VTGnprCQNPDFLRQIPLqdvafpdfr 718
Cdd:cd21340   50 HLYLQNNQIEKIEN--LENLVNLKKLYL-----GGNR-------------IsvVEG---LENLTNLEELHI--------- 97

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12621130  719 ceEGQeevgCLPRPQC-PQECACLDTVVRCsnkhLQALpkgipkNVTelyldGNQFTlVPGQLSTFKYLQLVDLSNNKIS 797
Cdd:cd21340   98 --ENQ----RLPPGEKlTFDPRSLAALSNS----LRVL------NIS-----GNNID-SLEPLAPLRNLEQLDASNNQIS 155

                        250       260
                 ....*....|....*....|...
gi 12621130  798 SLSN--SSFTNMSQLTTLILSYN 818
Cdd:cd21340  156 DLEEllDLLSSWPSLRELDLTGN 178
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 33-60 1.29e-04

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 40.30  E-value: 1.29e-04
                           10        20
                   ....*....|....*....|....*...
gi 12621130     33 ACPALCTCTGTTVDCHGTGLQAIPKNIP 60
Cdd:pfam01462    1 ACPVPCHCSATVVNCSDRGLTAVPRDLP 28
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 282-308 1.35e-04

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 40.30  E-value: 1.35e-04
                           10        20
                   ....*....|....*....|....*..
gi 12621130    282 CPAMCSCSNGIVDCRGKGLTAIPANLP 308
Cdd:pfam01462    2 CPVPCHCSATVVNCSDRGLTAVPRDLP 28
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1087-1115 1.41e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 40.44  E-value: 1.41e-04
                           10        20
                   ....*....|....*....|....*....
gi 12621130   1087 CKDHQCQNGAQCVDEINSYACLCAEGYSG 1115
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTG 29
LRRNT smart00013
Leucine rich repeat N-terminal domain;
512-544 1.64e-04

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 40.38  E-value: 1.64e-04
                            10        20        30
                    ....*....|....*....|....*....|...
gi 12621130     512 ACPHKCRCEASVVECSGLKLSKIPERIPQSTTE 544
Cdd:smart00013    1 ACPAPCNCSGTAVDCSGRGLTEVPLDLPPDTTL 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
1005-1041 1.70e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.31  E-value: 1.70e-04
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 12621130    1005 NTDDCV-KHDCVNGGVCVDGIGNYTCQCPLQYT-GRACE 1041
Cdd:smart00179    1 DIDECAsGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
LRRNT smart00013
Leucine rich repeat N-terminal domain;
733-765 1.88e-04

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 39.99  E-value: 1.88e-04
                            10        20        30
                    ....*....|....*....|....*....|...
gi 12621130     733 QCPQECACLDTVVRCSNKHLQALPKGIPKNVTE 765
Cdd:smart00013    1 ACPAPCNCSGTAVDCSGRGLTEVPLDLPPDTTL 33
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 183-220 2.77e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 39.92  E-value: 2.77e-04
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 12621130    183 LEVLTLNNNNITTIPvsSFNHMPKLRTFRLHSNHLFCD 220
Cdd:pfam12799    3 LEVLDLSNNQITDIP--PLAKLPNLETLDLSGNNKITD 38
LRRCT smart00082
Leucine rich repeat C-terminal domain;
439-469 3.26e-04

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 39.72  E-value: 3.26e-04
                            10        20        30
                    ....*....|....*....|....*....|...
gi 12621130     439 NPFICDCNLKWLADFLRTNPI--ETTGARCASP 469
Cdd:smart00082    1 NPFICDCELRWLLRWLQANEHlqDPVDLRCASP 33
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 556-673 3.62e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 45.22  E-value: 3.62e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12621130   556 EATGLFKKLSHLKKINLSNNKVS-EIEDGTFEGATSVSELHLTANQLESVRSGMFrgLDGLRTLMLRNNRISC-IHND-- 631
Cdd:PLN00113   84 KISSAIFRLPYIQTINLSNNQLSgPIPDDIFTTSSSLRYLNLSNNNFTGSIPRGS--IPNLETLDLSNNMLSGeIPNDig 161

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 12621130   632 SFTglrNVRLLSLYDNHITTISPGAFDTLQALSTLNLLANPF 673
Cdd:PLN00113  162 SFS---SLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQL 200
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 334-373 3.69e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 39.54  E-value: 3.69e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 12621130    334 KLRRIDLSNNQIAEIapDAFQGLRSLNSLVLYGN-KITDLP 373
Cdd:pfam12799    2 NLEVLDLSNNQITDI--PPLAKLPNLETLDLSGNnKITDLS 40
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1050-1079 5.40e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 38.90  E-value: 5.40e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 12621130   1050 DLNPCQHEAQCVGTPEGPRCECVPGYTGDN 1079
Cdd:pfam00008    2 APNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
966-1002 6.10e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.77  E-value: 6.10e-04
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 12621130     966 DSCSS-NPCGNGGTCHAQEGedaGFTCSCPSGFE-GLTC 1002
Cdd:smart00179    3 DECASgNPCQNGGTCVNTVG---SYRCECPPGYTdGRNC 38
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 398-627 6.54e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 43.50  E-value: 6.54e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12621130  398 PDAFQDLQNLSLLSLYDNKIQSLAKGTFTSLRAIQTLHLAQnpficdcnlkwladfLRTNPIETTGAR--CASPRRLank 475
Cdd:cd00116   74 LQGLTKGCGLQELDLSDNALGPDGCGVLESLLRSSSLQELK---------------LNNNGLGDRGLRllAKGLKDL--- 135

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12621130  476 rigQIKSKKFRCSakeqyfipgteDYHLNSECTSDVA--CPHKCRCEasvvecsglklskiperipqsttELRLNNNEIS 553
Cdd:cd00116  136 ---PPALEKLVLG-----------RNRLEGASCEALAkaLRANRDLK-----------------------ELNLANNGIG 178

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12621130  554 ILEATGL---FKKLSHLKKINLSNNKVSEIEDGTFEGA----TSVSELHLTANQLESV-----RSGMFRGLDGLRTLMLR 621
Cdd:cd00116  179 DAGIRALaegLKANCNLEVLDLNNNGLTDEGASALAETlaslKSLEVLNLGDNNLTDAgaaalASALLSPNISLLTLSLS 258


                 ....*.
gi 12621130  622 NNRISC 627
Cdd:cd00116  259 CNDITD 264
LRRCT smart00082
Leucine rich repeat C-terminal domain;
219-264 8.31e-04

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 38.57  E-value: 8.31e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*...
gi 12621130     219 CDCHLAWLSQWLRQRPTIGLF--TQCSGPASLRGLnVAEVQKSEFSCS 264
Cdd:smart00082    5 CDCELRWLLRWLQANEHLQDPvdLRCASPSSLRGP-LLELLHSEFKCP 51
EGF_CA smart00179
Calcium-binding EGF-like domain;
1044-1080 8.86e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.38  E-value: 8.86e-04
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 12621130    1044 VDFCSPDlNPCQHEAQCVGTPEGPRCECVPGYT-GDNC 1080
Cdd:smart00179    2 IDECASG-NPCQNGGTCVNTVGSYRCECPPGYTdGRNC 38
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 1052-1079 9.98e-04

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 38.23  E-value: 9.98e-04
                         10        20
                 ....*....|....*....|....*...
gi 12621130 1052 NPCQHEAQCVGTPEGPRCECVPGYTGDN 1079
Cdd:cd00053    6 NPCSNGGTCVNTPGSYRCVCPPGYTGDR 33
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 543-582 1.20e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 38.00  E-value: 1.20e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 12621130    543 TELRLNNNEISILEatgLFKKLSHLKKINLS-NNKVSEIED 582
Cdd:pfam12799    4 EVLDLSNNQITDIP---PLAKLPNLETLDLSgNNKITDLSD 41
EGF_CA smart00179
Calcium-binding EGF-like domain;
927-962 1.78e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.61  E-value: 1.78e-03
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 12621130     927 DPCLS-SPCQNQGTCHNDPLEvYRCTCPSGYK-GRNCE 962
Cdd:smart00179    3 DECASgNPCQNGGTCVNTVGS-YRCECPPGYTdGRNCE 39
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 733-760 2.18e-03

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 36.84  E-value: 2.18e-03
                           10        20
                   ....*....|....*....|....*...
gi 12621130    733 QCPQECACLDTVVRCSNKHLQALPKGIP 760
Cdd:pfam01462    1 ACPVPCHCSATVVNCSDRGLTAVPRDLP 28
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 929-960 2.18e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.98  E-value: 2.18e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 12621130    929 CLSSPCQNQGTCHNDPlEVYRCTCPSGYKGRN 960
Cdd:pfam00008    1 CAPNPCSNGGTCVDTP-GGYTCICPEGYTGKR 31
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 930-962 2.30e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 37.07  E-value: 2.30e-03
                         10        20        30
                 ....*....|....*....|....*....|....
gi 12621130  930 LSSPCQNQGTCHNDPlEVYRCTCPSGYKG-RNCE 962
Cdd:cd00053    4 ASNPCSNGGTCVNTP-GSYRCVCPPGYTGdRSCE 36
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 512-539 2.70e-03

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 36.84  E-value: 2.70e-03
                           10        20
                   ....*....|....*....|....*...
gi 12621130    512 ACPHKCRCEASVVECSGLKLSKIPERIP 539
Cdd:pfam01462    1 ACPVPCHCSATVVNCSDRGLTAVPRDLP 28
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1009-1038 3.02e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.59  E-value: 3.02e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 12621130   1009 CVKHDCVNGGVCVDGIGNYTCQCPLQYTGR 1038
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGK 30
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 1090-1116 3.38e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 36.69  E-value: 3.38e-03
                         10        20
                 ....*....|....*....|....*..
gi 12621130 1090 HQCQNGAQCVDEINSYACLCAEGYSGQ 1116
Cdd:cd00053    6 NPCSNGGTCVNTPGSYRCVCPPGYTGD 32
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 538-672 3.40e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 41.70  E-value: 3.40e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12621130  538 IPQSTTELRLNNNEISILEATGLFKKLSHLKKI---NLSNNKVSEiedgtfEGA----------TSVSELHLTANQL--E 602
Cdd:COG5238  206 QNTTVTTLWLKRNPIGDEGAEILAEALKGNKSLttlDLSNNQIGD------EGVialaealknnTTVETLYLSGNQIgaE 279

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12621130  603 SVR--SGMFRGLDGLRTLMLRNNRIScihNDSFTGLRN-------VRLLSLYDNHITTisPGA---FDTLQA---LSTLN 667
Cdd:COG5238  280 GAIalAKALQGNTTLTSLDLSVNRIG---DEGAIALAEglqgnktLHTLNLAYNGIGA--QGAialAKALQEnttLHSLD 354


                 ....*
gi 12621130  668 LLANP 672
Cdd:COG5238  355 LSDNQ 359
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 969-999 3.85e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 36.30  E-value: 3.85e-03
                         10        20        30
                 ....*....|....*....|....*....|.
gi 12621130  969 SSNPCGNGGTCHAQEGedaGFTCSCPSGFEG 999
Cdd:cd00053    4 ASNPCSNGGTCVNTPG---SYRCVCPPGYTG 31
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 319-441 4.00e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 40.54  E-value: 4.00e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12621130  319 NGIKSIPpgAFSPYRKLRRIDLSNNQIAEIAPdaFQGLRSLNSLVLYGNKIT-------------------DLPRGV--- 376
Cdd:cd21340   34 NKITKIE--NLEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRISvveglenltnleelhienqRLPPGEklt 109

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 12621130  377 FGGLYTLQLLLL----NA--NKINCIRPdaFQDLQNLSLLSLYDNKIQSLA--KGTFTSLRAIQTLHLAQNPF 441
Cdd:cd21340  110 FDPRSLAALSNSlrvlNIsgNNIDSLEP--LAPLRNLEQLDASNNQISDLEelLDLLSSWPSLRELDLTGNPV 180
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 968-1001 4.65e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.21  E-value: 4.65e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 12621130    968 CSSNPCGNGGTCHAQEGedaGFTCSCPSGFEGLT 1001
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPG---GYTCICPEGYTGKR 31
LRR_5 pfam13306
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ...
 567-657 4.88e-03

BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 463839 [Multi-domain]  Cd Length: 127  Bit Score: 38.68  E-value: 4.88e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12621130    567 LKKINLSNNkVSEIEDGTFEGATSVSELHLTaNQLESVRSGMFRGLdGLRTLMLRNNrISCIHNDSFTGLRNVRLLSLYD 646
Cdd:pfam13306   13 LTSITIPSS-LTSIGEYAFSNCTSLKSITLP-SSLTSIGSYAFYNC-SLTSITIPSS-LTSIGEYAFSNCSNLKSITLPS 88

                           90
                   ....*....|.
gi 12621130    647 NhITTISPGAF 657
Cdd:pfam13306   89 N-LTSIGSYAF 98
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 55-217 5.34e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 41.37  E-value: 5.34e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12621130    55 IPKNIPR--NTERLELNGNNITRIHKNDFAGLKQLRVLQLMENQIGAVERGAFDDMKELERLRLNRNQLQVLPELLFQNN 132
Cdd:PLN00113  348 IPKNLGKhnNLTVLDLSTNNLTGEIPEGLCSSGNLFKLILFSNSLEGEIPKSLGACRSLRRVRLQDNSFSGELPSEFTKL 427

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12621130   133 QALSRLDLSENSLQA----------------VPRKAFRG-------ATDLKNLQLDKNQISCIEEGAFRALRGLEVLTLN 189
Cdd:PLN00113  428 PLVYFLDISNNNLQGrinsrkwdmpslqmlsLARNKFFGglpdsfgSKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLS 507

                         170       180
                  ....*....|....*....|....*...
gi 12621130   190 NNNITTIPVSSFNHMPKLRTFRLHSNHL 217
Cdd:PLN00113  508 ENKLSGEIPDELSSCKKLVSLDLSHNQL 535
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 615-654 5.43e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 36.07  E-value: 5.43e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 12621130    615 LRTLMLRNNRISCIhnDSFTGLRNVRLLSLYDN-HITTISP 654
Cdd:pfam12799    3 LEVLDLSNNQITDI--PPLAKLPNLETLDLSGNnKITDLSD 41
hEGF pfam12661
Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six ...
 1092-1113 6.04e-03

Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six conserved residues disulfide-bonded into the characteriztic 'ababcc' pattern. They are involved in growth and proliferation of cells, in proteins of the Notch/Delta pathway, neurogulin and selectins. hEGFs are also found in mosaic proteins with four-disulfide laminin EGFs such as aggrecan and perlecan. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal Cys residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In hEGFs the C-terminal thiol resides in the beta-turn, resulting in shorter loop-lengths between the Cys residues of disulfide 'c', typically C[8-9]XC. These shorter loop-lengths are also typical of the four-disulfide EGF domains, laminin ad integrin. Tandem hEGF domains have six linking residues between terminal cysteines of adjacent domains. hEGF domains may or may not bind calcium in the linker region. hEGF domains with the consensus motif CXD4X[F,Y]XCXC are hydroxylated exclusively in the Asp residue.


Pssm-ID: 463660  Cd Length: 22  Bit Score: 35.77  E-value: 6.04e-03
                           10        20
                   ....*....|....*....|..
gi 12621130   1092 CQNGAQCVDEINSYACLCAEGY 1113
Cdd:pfam12661    1 CQNGGTCVDGVNGYKCQCPPGY 22
LRR_8 pfam13855
Leucine rich repeat;
637-668 6.35e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 36.35  E-value: 6.35e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 12621130    637 RNVRLLSLYDNHITTISPGAFDTLQALSTLNL 668
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDL 32
PLN03150 PLN03150
hypothetical protein; Provisional
 776-820 7.16e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 40.95  E-value: 7.16e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 12621130   776 VPGQLSTFKYLQLVDLSNNKISSLSNSSFTNMSQLTTLILSYNAL 820
Cdd:PLN03150  434 IPNDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSF 478
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 66-150 8.04e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 39.38  E-value: 8.04e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12621130   66 LELNGNNITRIhkNDFAGLKQLRVLQLMENQIgavergafDDMKELERlrlnrnqlqvlpelLFQNNQALSRLDLSENSL 145
Cdd:cd21340  125 LNISGNNIDSL--EPLAPLRNLEQLDASNNQI--------SDLEELLD--------------LLSSWPSLRELDLTGNPV 180


                 ....*
gi 12621130  146 QAVPR 150
Cdd:cd21340  181 CKKPK 185
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
43-196 8.26e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 40.30  E-value: 8.26e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12621130   43 TTVDCHGTGLQAIP--KNIPrNTERLELNGNNITRIhkNDFAGLKQLRVLQLMENQIGAVergafddmkELERLRLNRNQ 120
Cdd:COG4886  231 ETLDLSNNQLTDLPelGNLT-NLEELDLSNNQLTDL--PPLANLTNLKTLDLSNNQLTDL---------KLKELELLLGL 298

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 12621130  121 LQVLPELLFQNNQALSRLDLSENSLQAVPRKAFRGATDLKNLQLDKNQISCIEEGAFRALRGLEVLTLNNNNITTI 196
Cdd:COG4886  299 NSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGL 374
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 761-825 8.96e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 39.38  E-value: 8.96e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 12621130  761 KNVTELYLDGNQFTLVPGqLSTFKYLQLVDLSNNKISSLSNssFTNMSQLTTLILSYnalQCIPP 825
Cdd:cd21340   46 TNLTHLYLQNNQIEKIEN-LENLVNLKKLYLGGNRISVVEG--LENLTNLEELHIEN---QRLPP 104
LRR smart00370
Leucine-rich repeats, outliers;
180-203 9.39e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 35.02  E-value: 9.39e-03
                            10        20
                    ....*....|....*....|....
gi 12621130     180 LRGLEVLTLNNNNITTIPVSSFNH 203
Cdd:smart00370    1 LPNLRELDLSNNQLSSLPPGAFQG 24
LRR_TYP smart00369
Leucine-rich repeats, typical (most populated) subfamily;
180-203 9.39e-03

Leucine-rich repeats, typical (most populated) subfamily;


Pssm-ID: 197687 [Multi-domain]  Cd Length: 24  Bit Score: 35.02  E-value: 9.39e-03
                            10        20
                    ....*....|....*....|....
gi 12621130     180 LRGLEVLTLNNNNITTIPVSSFNH 203
Cdd:smart00369    1 LPNLRELDLSNNQLSSLPPGAFQG 24
LRR_8 pfam13855
Leucine rich repeat;
405-439 9.99e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.96  E-value: 9.99e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 12621130    405 QNLSLLSLYDNKIQSLAKGTFTSLRAIQTLHLAQN 439
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNN 35
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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