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Conserved domains on  [gi|31542438|ref|NP_079834|]
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cytochrome b5 type B precursor [Mus musculus]

Protein Classification

cytochrome b5-like heme/steroid binding domain-containing protein( domain architecture ID 10445738)

cytochrome b5-like heme/steroid binding domain-containing protein such as cytochrome b5, a membrane-bound hemoprotein that functions as an electron carrier for several membrane-bound oxygenases and Arabidopsis thaliana steroid-binding proteins

CATH:  3.10.120.10
Gene Ontology:  GO:0097159|GO:0016020
PubMed:  12537557|7893819

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cyt-b5 pfam00173
Cytochrome b5-like Heme/Steroid binding domain; This family includes heme binding domains from ...
 24-96 9.49e-32

Cytochrome b5-like Heme/Steroid binding domain; This family includes heme binding domains from a diverse range of proteins. This family also includes proteins that bind to steroids. The family includes progesterone receptors. Many members of this subfamily are membrane anchored by an N-terminal transmembrane alpha helix. This family also includes a domain in some chitin synthases. There is no known ligand for this domain in the chitin synthases.


:

Pssm-ID: 459698 [Multi-domain]  Cd Length: 74  Bit Score: 108.09  E-value: 9.49e-32
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 31542438    24 RLEEVAKRNSAEETWMVIHGRVYDITRFLSEHPGGEEVLLEQAGADATESFEDVGHSPD-AREMLKQYYIGDVH 96
Cdd:pfam00173   1 TLEELSKHNGDGDCWVAINGKVYDVTKFLKEHPGGEDVILSAAGKDATDAFEAIGHSEDaAEKLLKKYRIGELA 74
MIP super family cl00200
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane ...
 119-139 1.38e-03

Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal cytosolic portion followed by six transmembrane helices, which might have arisen through gene duplication. On the basis of sequence similarity and functional characteristics, the superfamily can be subdivided into two major groups: water-selective channels called aquaporins (AQPs) and glycerol uptake facilitators (GlpFs). AQPs are found in all three kingdoms of life, while GlpFs have been characterized only within microorganisms.


The actual alignment was detected with superfamily member cd00333:

Pssm-ID: 444743  Cd Length: 228  Bit Score: 37.23  E-value: 1.38e-03
                        10        20
                ....*....|....*....|.
gi 31542438 119 WAYWFVPIVGAILIGFLYRHF 139
Cdd:cd00333 208 WVYWVGPLIGAIAGALVYDYV 228
 
Name Accession Description Interval E-value
Cyt-b5 pfam00173
Cytochrome b5-like Heme/Steroid binding domain; This family includes heme binding domains from ...
 24-96 9.49e-32

Cytochrome b5-like Heme/Steroid binding domain; This family includes heme binding domains from a diverse range of proteins. This family also includes proteins that bind to steroids. The family includes progesterone receptors. Many members of this subfamily are membrane anchored by an N-terminal transmembrane alpha helix. This family also includes a domain in some chitin synthases. There is no known ligand for this domain in the chitin synthases.


Pssm-ID: 459698 [Multi-domain]  Cd Length: 74  Bit Score: 108.09  E-value: 9.49e-32
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 31542438    24 RLEEVAKRNSAEETWMVIHGRVYDITRFLSEHPGGEEVLLEQAGADATESFEDVGHSPD-AREMLKQYYIGDVH 96
Cdd:pfam00173   1 TLEELSKHNGDGDCWVAINGKVYDVTKFLKEHPGGEDVILSAAGKDATDAFEAIGHSEDaAEKLLKKYRIGELA 74
PLN02252 PLN02252
nitrate reductase [NADPH]
 18-131 7.86e-29

nitrate reductase [NADPH]


Pssm-ID: 215141 [Multi-domain]  Cd Length: 888  Bit Score: 110.15  E-value: 7.86e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542438   18 PSVTYYRLEEVAKRNSAEETWMVIHGRVYDITRFLSEHPGGEEVLLEQAGADATESFEDVgHSPDAREMLKQYYIGDVHP 97
Cdd:PLN02252 515 TGSKQYTMSEVRKHNSEDSCWIVVHGHVYDCTRFLKDHPGGADSILINAGTDCTEEFDAI-HSDKAKKMLEDYRIGELVT 593

                         90       100       110
                 ....*....|....*....|....*....|....
gi 31542438   98 SDLKPKGDDKDPSKNNSCQSSWAYWFVPIVGAIL 131
Cdd:PLN02252 594 TGAAASSSASSHPLSAISTASALAAASPAPGRPV 627
CYB5 COG5274
Cytochrome b involved in lipid metabolism [Energy production and conversion, Lipid transport ...
 18-95 1.76e-25

Cytochrome b involved in lipid metabolism [Energy production and conversion, Lipid transport and metabolism];


Pssm-ID: 444085 [Multi-domain]  Cd Length: 93  Bit Score: 92.79  E-value: 1.76e-25
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 31542438  18 PSVTYYRLEEVAKRNSAEETWMVIHGRVYDITRFLSEHPGGEEVLLEQAGADATESFEDV-GHSPDAREMLKQYYIGDV 95
Cdd:COG5274  13 APEKTYTLAEVATHNTLSDCWMAIDGNVYDLTEYIPKHPGGEAVILRWCGKDATEAFNTKhPHSPKAERLLESYRIGRL 91
MIP cd00333
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane ...
 119-139 1.38e-03

Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal cytosolic portion followed by six transmembrane helices, which might have arisen through gene duplication. On the basis of sequence similarity and functional characteristics, the superfamily can be subdivided into two major groups: water-selective channels called aquaporins (AQPs) and glycerol uptake facilitators (GlpFs). AQPs are found in all three kingdoms of life, while GlpFs have been characterized only within microorganisms.


Pssm-ID: 238204  Cd Length: 228  Bit Score: 37.23  E-value: 1.38e-03
                        10        20
                ....*....|....*....|.
gi 31542438 119 WAYWFVPIVGAILIGFLYRHF 139
Cdd:cd00333 208 WVYWVGPLIGAIAGALVYDYV 228
GlpF COG0580
Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) ...
 118-141 3.25e-03

Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) [Carbohydrate transport and metabolism];


Pssm-ID: 440345 [Multi-domain]  Cd Length: 232  Bit Score: 36.26  E-value: 3.25e-03
                        10        20
                ....*....|....*....|....
gi 31542438 118 SWAYWFVPIVGAILIGFLYRHFWA 141
Cdd:COG0580 209 LWVPIVAPILGAALAALLYRALFG 232
 
Name Accession Description Interval E-value
Cyt-b5 pfam00173
Cytochrome b5-like Heme/Steroid binding domain; This family includes heme binding domains from ...
 24-96 9.49e-32

Cytochrome b5-like Heme/Steroid binding domain; This family includes heme binding domains from a diverse range of proteins. This family also includes proteins that bind to steroids. The family includes progesterone receptors. Many members of this subfamily are membrane anchored by an N-terminal transmembrane alpha helix. This family also includes a domain in some chitin synthases. There is no known ligand for this domain in the chitin synthases.


Pssm-ID: 459698 [Multi-domain]  Cd Length: 74  Bit Score: 108.09  E-value: 9.49e-32
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 31542438    24 RLEEVAKRNSAEETWMVIHGRVYDITRFLSEHPGGEEVLLEQAGADATESFEDVGHSPD-AREMLKQYYIGDVH 96
Cdd:pfam00173   1 TLEELSKHNGDGDCWVAINGKVYDVTKFLKEHPGGEDVILSAAGKDATDAFEAIGHSEDaAEKLLKKYRIGELA 74
PLN02252 PLN02252
nitrate reductase [NADPH]
 18-131 7.86e-29

nitrate reductase [NADPH]


Pssm-ID: 215141 [Multi-domain]  Cd Length: 888  Bit Score: 110.15  E-value: 7.86e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542438   18 PSVTYYRLEEVAKRNSAEETWMVIHGRVYDITRFLSEHPGGEEVLLEQAGADATESFEDVgHSPDAREMLKQYYIGDVHP 97
Cdd:PLN02252 515 TGSKQYTMSEVRKHNSEDSCWIVVHGHVYDCTRFLKDHPGGADSILINAGTDCTEEFDAI-HSDKAKKMLEDYRIGELVT 593

                         90       100       110
                 ....*....|....*....|....*....|....
gi 31542438   98 SDLKPKGDDKDPSKNNSCQSSWAYWFVPIVGAIL 131
Cdd:PLN02252 594 TGAAASSSASSHPLSAISTASALAAASPAPGRPV 627
CYB5 COG5274
Cytochrome b involved in lipid metabolism [Energy production and conversion, Lipid transport ...
 18-95 1.76e-25

Cytochrome b involved in lipid metabolism [Energy production and conversion, Lipid transport and metabolism];


Pssm-ID: 444085 [Multi-domain]  Cd Length: 93  Bit Score: 92.79  E-value: 1.76e-25
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 31542438  18 PSVTYYRLEEVAKRNSAEETWMVIHGRVYDITRFLSEHPGGEEVLLEQAGADATESFEDV-GHSPDAREMLKQYYIGDV 95
Cdd:COG5274  13 APEKTYTLAEVATHNTLSDCWMAIDGNVYDLTEYIPKHPGGEAVILRWCGKDATEAFNTKhPHSPKAERLLESYRIGRL 91
PLN03198 PLN03198
delta6-acyl-lipid desaturase; Provisional
 23-103 7.14e-12

delta6-acyl-lipid desaturase; Provisional


Pssm-ID: 178739 [Multi-domain]  Cd Length: 526  Bit Score: 61.63  E-value: 7.14e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542438   23 YRLEEVAKRNSAEETWMVIHGRVYDITRFLSEHPGGeEVLLEQAGADATESFEDVgHSPDAREMLKQYYIGDVHPSDLKP 102
Cdd:PLN03198 106 HLLSEVAAHNKPNDCWIVIKNKVYDVSDFAAEHPGG-SVISTYFGRDGTDAFSSF-HAASTWKILQDFYIGDVDNVEPTP 183


                 .
gi 31542438  103 K 103
Cdd:PLN03198 184 E 184
PLN03199 PLN03199
delta6-acyl-lipid desaturase-like protein; Provisional
 23-103 1.69e-11

delta6-acyl-lipid desaturase-like protein; Provisional


Pssm-ID: 178740 [Multi-domain]  Cd Length: 485  Bit Score: 60.44  E-value: 1.69e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542438   23 YRLEEVAKRNSAEETWMVIHGRVYDITRFlSEHPGGEeVLLEQAGADATESFEDVgHSPDAREMLKQYYIGDVHPSDLKP 102
Cdd:PLN03199  26 ISWQEVKKHASPDDAWIIHQNKVYDVSNW-HDHPGGA-VIFTHAGDDMTDIFAAF-HAPGSQALMKKFYIGDLIPESTEH 102


                 .
gi 31542438  103 K 103
Cdd:PLN03199 103 K 103
MIP cd00333
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane ...
 119-139 1.38e-03

Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal cytosolic portion followed by six transmembrane helices, which might have arisen through gene duplication. On the basis of sequence similarity and functional characteristics, the superfamily can be subdivided into two major groups: water-selective channels called aquaporins (AQPs) and glycerol uptake facilitators (GlpFs). AQPs are found in all three kingdoms of life, while GlpFs have been characterized only within microorganisms.


Pssm-ID: 238204  Cd Length: 228  Bit Score: 37.23  E-value: 1.38e-03
                        10        20
                ....*....|....*....|.
gi 31542438 119 WAYWFVPIVGAILIGFLYRHF 139
Cdd:cd00333 208 WVYWVGPLIGAIAGALVYDYV 228
GlpF COG0580
Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) ...
 118-141 3.25e-03

Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) [Carbohydrate transport and metabolism];


Pssm-ID: 440345 [Multi-domain]  Cd Length: 232  Bit Score: 36.26  E-value: 3.25e-03
                        10        20
                ....*....|....*....|....
gi 31542438 118 SWAYWFVPIVGAILIGFLYRHFWA 141
Cdd:COG0580 209 LWVPIVAPILGAALAALLYRALFG 232
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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