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Conserved domains on  [gi|44662811|ref|NP_080855|]
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NOP protein chaperone 1 [Mus musculus]

Protein Classification

NOPCHAP1/New4 family protein( domain architecture ID 143018)

NOPCHAP1/New4 family protein is a DUF4598 domain-containing protein similar to human NOP protein chaperone 1 (NOPCHAP1), a client-loading PAQosome/R2TP complex cofactor that selects NOP58 to promote box C/D small nucleolar ribonucleoprotein (snoRNP) assembly

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NOPCHAP1 super family cl21208
NOP protein chaperone 1; This entry includes NOPCHAP1 from animals and New4 from fission yeast. ...
 68-132 1.45e-13

NOP protein chaperone 1; This entry includes NOPCHAP1 from animals and New4 from fission yeast. NOPCHAP1 is a client-loading PAQosome/R2TP complex cofactor that selects NOP58 to promote box C/D small nucleolar ribonucleoprotein (snoRNP) assembly. The function of New4 is not clear.


The actual alignment was detected with superfamily member pfam15370:

Pssm-ID: 405951  Cd Length: 111  Bit Score: 63.89  E-value: 1.45e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 44662811    68 LLDQVQAFLPQMAQANEKLRREMAAAPAGHFNIENIDETSGNIIQMDVAL--FEMSRSDSKEEDSPE 132
Cdd:pfam15370   1 LLSRLSAFLPQLKAANEDLEREIAAGRGADLDIDDVDDDEEQYIEMNLGLgvLEEKRDDSSESDSDS 67
 
Name Accession Description Interval E-value
NOPCHAP1 pfam15370
NOP protein chaperone 1; This entry includes NOPCHAP1 from animals and New4 from fission yeast. ...
 68-132 1.45e-13

NOP protein chaperone 1; This entry includes NOPCHAP1 from animals and New4 from fission yeast. NOPCHAP1 is a client-loading PAQosome/R2TP complex cofactor that selects NOP58 to promote box C/D small nucleolar ribonucleoprotein (snoRNP) assembly. The function of New4 is not clear.


Pssm-ID: 405951  Cd Length: 111  Bit Score: 63.89  E-value: 1.45e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 44662811    68 LLDQVQAFLPQMAQANEKLRREMAAAPAGHFNIENIDETSGNIIQMDVAL--FEMSRSDSKEEDSPE 132
Cdd:pfam15370   1 LLSRLSAFLPQLKAANEDLEREIAAGRGADLDIDDVDDDEEQYIEMNLGLgvLEEKRDDSSESDSDS 67
 
Name Accession Description Interval E-value
NOPCHAP1 pfam15370
NOP protein chaperone 1; This entry includes NOPCHAP1 from animals and New4 from fission yeast. ...
 68-132 1.45e-13

NOP protein chaperone 1; This entry includes NOPCHAP1 from animals and New4 from fission yeast. NOPCHAP1 is a client-loading PAQosome/R2TP complex cofactor that selects NOP58 to promote box C/D small nucleolar ribonucleoprotein (snoRNP) assembly. The function of New4 is not clear.


Pssm-ID: 405951  Cd Length: 111  Bit Score: 63.89  E-value: 1.45e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 44662811    68 LLDQVQAFLPQMAQANEKLRREMAAAPAGHFNIENIDETSGNIIQMDVAL--FEMSRSDSKEEDSPE 132
Cdd:pfam15370   1 LLSRLSAFLPQLKAANEDLEREIAAGRGADLDIDDVDDDEEQYIEMNLGLgvLEEKRDDSSESDSDS 67
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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