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Conserved domains on  [gi|13386198|ref|NP_081363|]
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keratin associated protein 4-13 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Keratin_B2 super family cl37504
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 3-139 8.03e-20

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


The actual alignment was detected with superfamily member pfam01500:

Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 80.99  E-value: 8.03e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13386198     3 SSCCGSVCSEEG-CGQSCCQPSCCQTTCCRPSCCVSSCCRPSCCRPSCCVSSCcrPQCCQSVCCQPTCCRPSCCISSC-- 79
Cdd:pfam01500   7 SFCGFPTCSTGGtCGSGCCQPCCCQSSCCRPSCCQTSCCQPTTFQSSCCRPTC--QPCCQTSCCQPTCCQTSSCQTGCgg 84

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 13386198    80 -------------CRPSCCRPSCCVSSCCRPQCCQSVCCQPTCCRPSCCRPCCGSSSCCVSSCCRPQCCISSC 139
Cdd:pfam01500  85 igygqegssgavsSRTRWCRPDCRVEGTCLPPCCVVSCTPPTCCQLHHAQASCCRPSYCGQSCCRPACCCQCS 157
 
Name Accession Description Interval E-value
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 3-139 8.03e-20

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 80.99  E-value: 8.03e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13386198     3 SSCCGSVCSEEG-CGQSCCQPSCCQTTCCRPSCCVSSCCRPSCCRPSCCVSSCcrPQCCQSVCCQPTCCRPSCCISSC-- 79
Cdd:pfam01500   7 SFCGFPTCSTGGtCGSGCCQPCCCQSSCCRPSCCQTSCCQPTTFQSSCCRPTC--QPCCQTSCCQPTCCQTSSCQTGCgg 84

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 13386198    80 -------------CRPSCCRPSCCVSSCCRPQCCQSVCCQPTCCRPSCCRPCCGSSSCCVSSCCRPQCCISSC 139
Cdd:pfam01500  85 igygqegssgavsSRTRWCRPDCRVEGTCLPPCCVVSCTPPTCCQLHHAQASCCRPSYCGQSCCRPACCCQCS 157
NosR COG3901
Transcriptional regulator NosR of nitric oxide reductase [Transcription];
24-106 3.79e-06

Transcriptional regulator NosR of nitric oxide reductase [Transcription];


Pssm-ID: 443108 [Multi-domain]  Cd Length: 713  Bit Score: 45.70  E-value: 3.79e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13386198  24 CCQTTCCRPSCCVSSCCRPSCCRPSCCVSSCCRPQCCQSVCCQPTCCRPSCCISSCCRPSCCrpsCCvssCCRPQCCQSV 103
Cdd:COG3901 605 FFRRLCLLGLALAAAALARRRLWRRRRRECCCGCCCCCCKCCCIVIIIDGIIIINECCCCCC---LC---CRRCQDDPLC 678


                ...
gi 13386198 104 CCQ 106
Cdd:COG3901 679 PPR 681
 
Name Accession Description Interval E-value
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 3-139 8.03e-20

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 80.99  E-value: 8.03e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13386198     3 SSCCGSVCSEEG-CGQSCCQPSCCQTTCCRPSCCVSSCCRPSCCRPSCCVSSCcrPQCCQSVCCQPTCCRPSCCISSC-- 79
Cdd:pfam01500   7 SFCGFPTCSTGGtCGSGCCQPCCCQSSCCRPSCCQTSCCQPTTFQSSCCRPTC--QPCCQTSCCQPTCCQTSSCQTGCgg 84

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 13386198    80 -------------CRPSCCRPSCCVSSCCRPQCCQSVCCQPTCCRPSCCRPCCGSSSCCVSSCCRPQCCISSC 139
Cdd:pfam01500  85 igygqegssgavsSRTRWCRPDCRVEGTCLPPCCVVSCTPPTCCQLHHAQASCCRPSYCGQSCCRPACCCQCS 157
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 18-165 3.30e-15

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 68.66  E-value: 3.30e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13386198    18 SCCQPSCCQ-TTCCRPSCCVSSCCRPSCCRPSCCVSSCCRPQCCQSVCCQPTCCRPSCciSSCCRPSCCRPSCCVSSCCR 96
Cdd:pfam01500   2 ACCGTSFCGfPTCSTGGTCGSGCCQPCCCQSSCCRPSCCQTSCCQPTTFQSSCCRPTC--QPCCQTSCCQPTCCQTSSCQ 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 13386198    97 PQCCQSVCCQPTCCRPSCCRPCCGSSSCCVSSCCRPQCCISSCCRPICCQTTCCRTTCCRPACSSGSCC 165
Cdd:pfam01500  80 TGCGGIGYGQEGSSGAVSSRTRWCRPDCRVEGTCLPPCCVVSCTPPTCCQLHHAQASCCRPSYCGQSCC 148
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
39-83 2.34e-14

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 63.56  E-value: 2.34e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 13386198    39 CCRPSCCRPSCCVSSCCRPQCCQSVCCQPTCCRPSCCISSCCRPS 83
Cdd:pfam13885   1 CCQPSCCQPSCCQPSCCQPSCCQPSCCQPSCCRPSCCRSSCCQPT 45
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
64-108 2.89e-14

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 63.17  E-value: 2.89e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 13386198    64 CCQPTCCRPSCCISSCCRPSCCRPSCCVSSCCRPQCCQSVCCQPT 108
Cdd:pfam13885   1 CCQPSCCQPSCCQPSCCQPSCCQPSCCQPSCCRPSCCRSSCCQPT 45
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
24-68 3.59e-14

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 62.78  E-value: 3.59e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 13386198    24 CCQTTCCRPSCCVSSCCRPSCCRPSCCVSSCCRPQCCQSVCCQPT 68
Cdd:pfam13885   1 CCQPSCCQPSCCQPSCCQPSCCQPSCCQPSCCRPSCCRSSCCQPT 45
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
54-97 4.08e-14

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 62.78  E-value: 4.08e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 13386198    54 CCRPQCCQSVCCQPTCCRPSCCISSCCRPSCCRPSCCVSSCCRP 97
Cdd:pfam13885   1 CCQPSCCQPSCCQPSCCQPSCCQPSCCQPSCCRPSCCRSSCCQP 44
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
29-73 1.32e-13

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 61.63  E-value: 1.32e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 13386198    29 CCRPSCCVSSCCRPSCCRPSCCVSSCCRPQCCQSVCCQPTCCRPS 73
Cdd:pfam13885   1 CCQPSCCQPSCCQPSCCQPSCCQPSCCQPSCCRPSCCRSSCCQPT 45
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
44-88 5.38e-13

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 60.09  E-value: 5.38e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 13386198    44 CCRPSCCVSSCCRPQCCQSVCCQPTCCRPSCCISSCCRPSCCRPS 88
Cdd:pfam13885   1 CCQPSCCQPSCCQPSCCQPSCCQPSCCQPSCCRPSCCRSSCCQPT 45
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
15-57 6.73e-13

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 59.70  E-value: 6.73e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 13386198    15 CGQSCCQPSCCQTTCCRPSCCVSSCCRPSCCRPSCCVSSCCRP 57
Cdd:pfam13885   2 CQPSCCQPSCCQPSCCQPSCCQPSCCQPSCCRPSCCRSSCCQP 44
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
34-75 5.06e-12

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 57.39  E-value: 5.06e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 13386198    34 CCVSSCCRPSCCRPSCCVSSCCRPQCCQSVCCQPTCCRPSCC 75
Cdd:pfam13885   1 CCQPSCCQPSCCQPSCCQPSCCQPSCCQPSCCRPSCCRSSCC 42
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
10-50 8.73e-10

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 51.61  E-value: 8.73e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 13386198    10 CSEEGCGQSCCQPSCCQTTCCRPSCCVSSCCRPSCCRPSCC 50
Cdd:pfam13885   2 CQPSCCQPSCCQPSCCQPSCCQPSCCQPSCCRPSCCRSSCC 42
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
3-48 1.36e-08

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 48.53  E-value: 1.36e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 13386198     3 SSCCGSVCseegCGQSCCQPSCCQTTCCRPSCCVSSCCRPSCCRPS 48
Cdd:pfam13885   4 PSCCQPSC----CQPSCCQPSCCQPSCCQPSCCRPSCCRSSCCQPT 45
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
74-109 6.70e-08

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 46.61  E-value: 6.70e-08
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 13386198    74 CCISSCCRPSCCRPSCCVSSCCRPQCCQSVCCQPTC 109
Cdd:pfam13885   1 CCQPSCCQPSCCQPSCCQPSCCQPSCCQPSCCRPSC 36
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
79-143 7.36e-08

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 46.61  E-value: 7.36e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 13386198    79 CCRPSCCRPSCCVSSCCRPQCCQSVCCQPTCCrpsccrpccgsssccvssccRPQCCISSCCRPI 143
Cdd:pfam13885   1 CCQPSCCQPSCCQPSCCQPSCCQPSCCQPSCC--------------------RPSCCRSSCCQPT 45
PMG pfam05287
PMG protein; This family consists of several mouse anagen-specific protein mKAP13 (PMG1 and ...
 2-163 3.43e-07

PMG protein; This family consists of several mouse anagen-specific protein mKAP13 (PMG1 and PMG2). PMG1 and 2 contain characteriztic repeats reminiscent of the keratin-associated proteins (KAPs). Both genes are expressed in growing hair follicles in skin as well as in sebaceous and eccrine sweat glands. Interestingly, expression is also detected in the mammary epithelium where it is limited to the onset of the pubertal growth phase and is independent of ovarian hormones. Their broad, developmentally controlled expression pattern, together with their unique amino acid composition, demonstrate that pmg-1 and pmg-2 constitute a novel KAP gene family participating in the differentiation of all epithelial cells forming the epidermal appendages.


Pssm-ID: 283053 [Multi-domain]  Cd Length: 180  Bit Score: 47.50  E-value: 3.43e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13386198     2 VSSCCGSVCSEEGCGQSCCQPSCCQTTCCRPSCCVSSCCRPSCCRPSCCVSSCCRPQCCQSVCCQPTCCRPSC-CISSCC 80
Cdd:pfam05287  23 VSSCGSSCPSNLSYSTDLCSPSSCQLGSSLRDNCQETCGEPTSCQTSSCEPCTSSTSYCVPSPCQRSCYSPRTsCVCSPC 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13386198    81 RPSCCRPSCCVSSCCRPQCCQSVCCQPtccrpSCCRPCCGSSSCCVSSCCRPQCCISSCCRPICCQTTCCRTTCCRPACS 160
Cdd:pfam05287 103 QTTSAGSLGFGSSSCQSLGYGSNSCQP-----LGCGSSGFRPLGCLSKGFQSLGYGSSFCRPSYVSSRSYQPSCFRPSCG 177


                  ...
gi 13386198   161 SGS 163
Cdd:pfam05287 178 SGF 180
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 2-69 4.77e-07

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 47.09  E-value: 4.77e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 13386198     2 VSSCCGSVCSEEGCGQSCCQPSCCQTTCCRPSCCVSSCCRP-----SCCRPSCCVSSCCRPQCCqSVCCQPTC 69
Cdd:pfam01500  90 EGSSGAVSSRTRWCRPDCRVEGTCLPPCCVVSCTPPTCCQLhhaqaSCCRPSYCGQSCCRPACC-CQCSEPTC 161
NosR COG3901
Transcriptional regulator NosR of nitric oxide reductase [Transcription];
24-106 3.79e-06

Transcriptional regulator NosR of nitric oxide reductase [Transcription];


Pssm-ID: 443108 [Multi-domain]  Cd Length: 713  Bit Score: 45.70  E-value: 3.79e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13386198  24 CCQTTCCRPSCCVSSCCRPSCCRPSCCVSSCCRPQCCQSVCCQPTCCRPSCCISSCCRPSCCrpsCCvssCCRPQCCQSV 103
Cdd:COG3901 605 FFRRLCLLGLALAAAALARRRLWRRRRRECCCGCCCCCCKCCCIVIIIDGIIIINECCCCCC---LC---CRRCQDDPLC 678


                ...
gi 13386198 104 CCQ 106
Cdd:COG3901 679 PPR 681
NosR COG3901
Transcriptional regulator NosR of nitric oxide reductase [Transcription];
39-108 5.61e-05

Transcriptional regulator NosR of nitric oxide reductase [Transcription];


Pssm-ID: 443108 [Multi-domain]  Cd Length: 713  Bit Score: 42.23  E-value: 5.61e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 13386198  39 CCRPSCCRPSC---------CVSSCCRPQCCQSVCCQPTCCRPSCCISSCCRPSCCRPSCCvssCCRPQCCQSVCCQPT 108
Cdd:COG3901 605 FFRRLCLLGLAlaaaalarrRLWRRRRRECCCGCCCCCCKCCCIVIIIDGIIIINECCCCC---CLCCRRCQDDPLCPP 680
NosR COG3901
Transcriptional regulator NosR of nitric oxide reductase [Transcription];
19-76 3.81e-03

Transcriptional regulator NosR of nitric oxide reductase [Transcription];


Pssm-ID: 443108 [Multi-domain]  Cd Length: 713  Bit Score: 36.84  E-value: 3.81e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 13386198  19 CCQPSCCQTTCCRPSCCvssCCRPSCCRPSCCVSSCCRPQCC-QSVCCQPTCCRPSCCI 76
Cdd:COG3901 628 RRRRRECCCGCCCCCCK---CCCIVIIIDGIIIINECCCCCClCCRRCQDDPLCPPRIK 683
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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