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Conserved domains on  [gi|124249208|ref|NP_081616|]
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lipase member N precursor [Mus musculus]

Protein Classification

lipase family protein( domain architecture ID 706631)

lipase family protein that may function as a lipase, catalyzing the hydrolysis of ester bonds of insoluble substrates such a triglycerides

EC:  3.1.1.-
Gene Ontology:  GO:0016298|GO:0016788|GO:0006629

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PLN02872 super family cl28691
triacylglycerol lipase
39-397 9.88e-54

triacylglycerol lipase


The actual alignment was detected with superfamily member PLN02872:

Pssm-ID: 215470 [Multi-domain]  Cd Length: 395  Bit Score: 183.14  E-value: 9.88e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124249208  39 SEIIMYNGYPSEEYDVTTADGYILAINRIPHGRAQTGQTgPRPVVYMQHALFADNAYWLENFANGSLGFILADAGYDVWM 118
Cdd:PLN02872  34 AQLIHPAGYSCTEHTIQTKDGYLLALQRVSSRNPRLGSQ-RGPPVLLQHGLFMAGDAWFLNSPEQSLGFILADHGFDVWV 112
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124249208 119 GNSRGNTWSRRHKTLSANEEKFWAFSFNEMAKYDLPGIIDFIVNKTgQEKLYFIGHSLGTTIGFVAFsTMPELAQRIKMN 198
Cdd:PLN02872 113 GNVRGTRWSYGHVTLSEKDKEFWDWSWQELALYDLAEMIHYVYSIT-NSKIFIVGHSQGTIMSLAAL-TQPNVVEMVEAA 190
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124249208 199 FALGPVISFKYPTS------VFTNL--FLLPKSIIKLVFGTK-GVLLEDknarmsfiTFCNQKLlqpLCSEFMSLWAGFN 269
Cdd:PLN02872 191 ALLCPISYLDHVTAplvlrmVFMHLdqMVVAMGIHQLNFRSDvLVKLLD--------SICEGHM---DCNDLLTSITGTN 259
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124249208 270 kKNMNMSRLDVYMAHAPTGSSIQNMLHIKQLYRSDEFRAYDWGSeAENMNHYNQSYPPLYDLTAMKVPTAIWA--GGHDV 347
Cdd:PLN02872 260 -CCFNASRIDYYLEYEPHPSSVKNLRHLFQMIRKGTFAHYDYGI-FKNLKLYGQVNPPAFDLSLIPKSLPLWMgyGGTDG 337
                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|
gi 124249208 348 LVTPQDVARILPQITNLRYFKQFPDWNHFDFVWGLDAPQRLYSKIISLMK 397
Cdd:PLN02872 338 LADVTDVEHTLAELPSKPELLYLENYGHIDFLLSTSAKEDVYNHMIQFFR 387
 
Name Accession Description Interval E-value
PLN02872 PLN02872
triacylglycerol lipase
39-397 9.88e-54

triacylglycerol lipase


Pssm-ID: 215470 [Multi-domain]  Cd Length: 395  Bit Score: 183.14  E-value: 9.88e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124249208  39 SEIIMYNGYPSEEYDVTTADGYILAINRIPHGRAQTGQTgPRPVVYMQHALFADNAYWLENFANGSLGFILADAGYDVWM 118
Cdd:PLN02872  34 AQLIHPAGYSCTEHTIQTKDGYLLALQRVSSRNPRLGSQ-RGPPVLLQHGLFMAGDAWFLNSPEQSLGFILADHGFDVWV 112
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124249208 119 GNSRGNTWSRRHKTLSANEEKFWAFSFNEMAKYDLPGIIDFIVNKTgQEKLYFIGHSLGTTIGFVAFsTMPELAQRIKMN 198
Cdd:PLN02872 113 GNVRGTRWSYGHVTLSEKDKEFWDWSWQELALYDLAEMIHYVYSIT-NSKIFIVGHSQGTIMSLAAL-TQPNVVEMVEAA 190
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124249208 199 FALGPVISFKYPTS------VFTNL--FLLPKSIIKLVFGTK-GVLLEDknarmsfiTFCNQKLlqpLCSEFMSLWAGFN 269
Cdd:PLN02872 191 ALLCPISYLDHVTAplvlrmVFMHLdqMVVAMGIHQLNFRSDvLVKLLD--------SICEGHM---DCNDLLTSITGTN 259
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124249208 270 kKNMNMSRLDVYMAHAPTGSSIQNMLHIKQLYRSDEFRAYDWGSeAENMNHYNQSYPPLYDLTAMKVPTAIWA--GGHDV 347
Cdd:PLN02872 260 -CCFNASRIDYYLEYEPHPSSVKNLRHLFQMIRKGTFAHYDYGI-FKNLKLYGQVNPPAFDLSLIPKSLPLWMgyGGTDG 337
                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|
gi 124249208 348 LVTPQDVARILPQITNLRYFKQFPDWNHFDFVWGLDAPQRLYSKIISLMK 397
Cdd:PLN02872 338 LADVTDVEHTLAELPSKPELLYLENYGHIDFLLSTSAKEDVYNHMIQFFR 387
Abhydro_lipase pfam04083
Partial alpha/beta-hydrolase lipase region; This family corresponds to a N-terminal part of an ...
39-99 2.92e-27

Partial alpha/beta-hydrolase lipase region; This family corresponds to a N-terminal part of an alpha/beta hydrolase domain.


Pssm-ID: 461162 [Multi-domain]  Cd Length: 63  Bit Score: 102.62  E-value: 2.92e-27
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 124249208   39 SEIIMYNGYPSEEYDVTTADGYILAINRIPHGRAQTGQTGPRPVVYMQHALFADNAYWLEN 99
Cdd:pfam04083   2 SEIIRYYGYPVEEHEVTTEDGYILTLHRIPAGRNNSNGKGGKPVVLLQHGLLASSDNWVTN 62
COG4757 COG4757
Predicted alpha/beta hydrolase [General function prediction only];
43-177 6.81e-09

Predicted alpha/beta hydrolase [General function prediction only];


Pssm-ID: 443790 [Multi-domain]  Cd Length: 289  Bit Score: 56.43  E-value: 6.81e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124249208  43 MYNGYPSEEYDVTTADGYILainripHGRAQTGQTGPRPVVYMQHALfADNAYWLENFANGslgfiLADAGYDVW----- 117
Cdd:COG4757    1 MSTAASPESVTITAADGYPL------AARLFPPAGPPRAVVLINPAT-GVPQRFYRPFARY-----LAERGFAVLtydyr 68
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 124249208 118 -MGNSRgNTWSRRHKtlsaneekfwaFSFNEMAKYDLPGIIDFIVNKTGQEKLYFIGHSLG 177
Cdd:COG4757   69 gIGLSR-PGSLRGFD-----------AGYRDWGELDLPAVLDALRARFPGLPLLLVGHSLG 117
 
Name Accession Description Interval E-value
PLN02872 PLN02872
triacylglycerol lipase
39-397 9.88e-54

triacylglycerol lipase


Pssm-ID: 215470 [Multi-domain]  Cd Length: 395  Bit Score: 183.14  E-value: 9.88e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124249208  39 SEIIMYNGYPSEEYDVTTADGYILAINRIPHGRAQTGQTgPRPVVYMQHALFADNAYWLENFANGSLGFILADAGYDVWM 118
Cdd:PLN02872  34 AQLIHPAGYSCTEHTIQTKDGYLLALQRVSSRNPRLGSQ-RGPPVLLQHGLFMAGDAWFLNSPEQSLGFILADHGFDVWV 112
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124249208 119 GNSRGNTWSRRHKTLSANEEKFWAFSFNEMAKYDLPGIIDFIVNKTgQEKLYFIGHSLGTTIGFVAFsTMPELAQRIKMN 198
Cdd:PLN02872 113 GNVRGTRWSYGHVTLSEKDKEFWDWSWQELALYDLAEMIHYVYSIT-NSKIFIVGHSQGTIMSLAAL-TQPNVVEMVEAA 190
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124249208 199 FALGPVISFKYPTS------VFTNL--FLLPKSIIKLVFGTK-GVLLEDknarmsfiTFCNQKLlqpLCSEFMSLWAGFN 269
Cdd:PLN02872 191 ALLCPISYLDHVTAplvlrmVFMHLdqMVVAMGIHQLNFRSDvLVKLLD--------SICEGHM---DCNDLLTSITGTN 259
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124249208 270 kKNMNMSRLDVYMAHAPTGSSIQNMLHIKQLYRSDEFRAYDWGSeAENMNHYNQSYPPLYDLTAMKVPTAIWA--GGHDV 347
Cdd:PLN02872 260 -CCFNASRIDYYLEYEPHPSSVKNLRHLFQMIRKGTFAHYDYGI-FKNLKLYGQVNPPAFDLSLIPKSLPLWMgyGGTDG 337
                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|
gi 124249208 348 LVTPQDVARILPQITNLRYFKQFPDWNHFDFVWGLDAPQRLYSKIISLMK 397
Cdd:PLN02872 338 LADVTDVEHTLAELPSKPELLYLENYGHIDFLLSTSAKEDVYNHMIQFFR 387
Abhydro_lipase pfam04083
Partial alpha/beta-hydrolase lipase region; This family corresponds to a N-terminal part of an ...
39-99 2.92e-27

Partial alpha/beta-hydrolase lipase region; This family corresponds to a N-terminal part of an alpha/beta hydrolase domain.


Pssm-ID: 461162 [Multi-domain]  Cd Length: 63  Bit Score: 102.62  E-value: 2.92e-27
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 124249208   39 SEIIMYNGYPSEEYDVTTADGYILAINRIPHGRAQTGQTGPRPVVYMQHALFADNAYWLEN 99
Cdd:pfam04083   2 SEIIRYYGYPVEEHEVTTEDGYILTLHRIPAGRNNSNGKGGKPVVLLQHGLLASSDNWVTN 62
Abhydrolase_1 pfam00561
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
81-381 8.03e-21

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 395444 [Multi-domain]  Cd Length: 245  Bit Score: 90.64  E-value: 8.03e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124249208   81 PVVYMQHALFADNAYWLENFANgslgfiLADAGYDVWMGNSRGNTWSRRHKTLSaneekfwafsfnEMAKYDLPGIIDFI 160
Cdd:pfam00561   1 PPVLLLHGLPGSSDLWRKLAPA------LARDGFRVIALDLRGFGKSSRPKAQD------------DYRTDDLAEDLEYI 62
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124249208  161 VNKTGQEKLYFIGHSLGTTIGFVAFSTMPElaqRIKMNFALGPVisfkyptSVFTNLFLLPKSIIKLVFGTKGVLLEDKN 240
Cdd:pfam00561  63 LEALGLEKVNLVGHSMGGLIALAYAAKYPD---RVKALVLLGAL-------DPPHELDEADRFILALFPGFFDGFVADFA 132
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124249208  241 ARMSFITFCNQKLLQPLCSEFMSLwagFNKKNMNMSRLDVYMAHAPTGSSIQNMLHIKQLYRSDEFRAYDWgseaenmnh 320
Cdd:pfam00561 133 PNPLGRLVAKLLALLLLRLRLLKA---LPLLNKRFPSGDYALAKSLVTGALLFIETWSTELRAKFLGRLDE--------- 200
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 124249208  321 ynqsypplydltamkvPTAIWAGGHDvLVTPQDVARILPQITNLRYFKQFPDWNHFDFVWG 381
Cdd:pfam00561 201 ----------------PTLIIWGDQD-PLVPPQALEKLAQLFPNARLVVIPDAGHFAFLEG 244
COG4757 COG4757
Predicted alpha/beta hydrolase [General function prediction only];
43-177 6.81e-09

Predicted alpha/beta hydrolase [General function prediction only];


Pssm-ID: 443790 [Multi-domain]  Cd Length: 289  Bit Score: 56.43  E-value: 6.81e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124249208  43 MYNGYPSEEYDVTTADGYILainripHGRAQTGQTGPRPVVYMQHALfADNAYWLENFANGslgfiLADAGYDVW----- 117
Cdd:COG4757    1 MSTAASPESVTITAADGYPL------AARLFPPAGPPRAVVLINPAT-GVPQRFYRPFARY-----LAERGFAVLtydyr 68
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 124249208 118 -MGNSRgNTWSRRHKtlsaneekfwaFSFNEMAKYDLPGIIDFIVNKTGQEKLYFIGHSLG 177
Cdd:COG4757   69 gIGLSR-PGSLRGFD-----------AGYRDWGELDLPAVLDALRARFPGLPLLLVGHSLG 117
PldB COG2267
Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];
48-196 6.11e-08

Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];


Pssm-ID: 441868 [Multi-domain]  Cd Length: 221  Bit Score: 52.70  E-value: 6.11e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124249208  48 PSEEYDVTTADGYILainripHGRAQTGQTGPRPVVYMQHAlFADNAYWLENFANGslgfiLADAGYDVWMGNSRGNTWS 127
Cdd:COG2267    2 TRRLVTLPTRDGLRL------RGRRWRPAGSPRGTVVLVHG-LGEHSGRYAELAEA-----LAAAGYAVLAFDLRGHGRS 69
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 124249208 128 RRHKTLSAneekfwafSFNEMAKyDLPGIIDFIVNKTGQeKLYFIGHSLGttiGFVAFSTMPELAQRIK 196
Cdd:COG2267   70 DGPRGHVD--------SFDDYVD-DLRAALDALRARPGL-PVVLLGHSMG---GLIALLYAARYPDRVA 125
Hydrolase_4 pfam12146
Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is ...
79-196 6.82e-04

Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is approximately 110 amino acids in length. It is found in association with pfam00561. The majority of the members in this family carry the exopeptidase active-site residues of Ser-122, Asp-239 and His-269 as in UniProtKB:Q7ZWC2.


Pssm-ID: 463473 [Multi-domain]  Cd Length: 238  Bit Score: 41.05  E-value: 6.82e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124249208   79 PRPVVYMQHAlFADNAYWLENFANgslgfILADAGYDVWMGNSRGntwsrrHKtLSANEEKFWAfSFNEMAKyDLPGIID 158
Cdd:pfam12146   3 PRAVVVLVHG-LGEHSGRYAHLAD-----ALAAQGFAVYAYDHRG------HG-RSDGKRGHVP-SFDDYVD-DLDTFVD 67
                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 124249208  159 FIVNKTGQEKLYFIGHSLGttiGFVAFSTMPELAQRIK 196
Cdd:pfam12146  68 KIREEHPGLPLFLLGHSMG---GLIAALYALRYPDKVD 102
EstA COG1075
Triacylglycerol esterase/lipase EstA, alpha/beta hydrolase fold [Lipid transport and ...
76-180 2.63e-03

Triacylglycerol esterase/lipase EstA, alpha/beta hydrolase fold [Lipid transport and metabolism];


Pssm-ID: 440693 [Multi-domain]  Cd Length: 106  Bit Score: 37.12  E-value: 2.63e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124249208  76 QTGPRPVVYMqHALFADNAYW--LENFangslgfiLADAGYDVWMGNsrgntWSRRHKTLSANEEKFWAFsfnemakydl 153
Cdd:COG1075    2 AATRYPVVLV-HGLGGSAASWapLAPR--------LRAAGYPVYALN-----YPSTNGSIEDSAEQLAAF---------- 57
                         90       100
                 ....*....|....*....|....*..
gi 124249208 154 pgiIDFIVNKTGQEKLYFIGHSLGTTI 180
Cdd:COG1075   58 ---VDAVLAATGAEKVDLVGHSMGGLV 81
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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