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Conserved domains on  [gi|71361678|ref|NP_084247|]
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pro-MCH preproprotein [Mus musculus]

Protein Classification

Pro-MCH domain-containing protein( domain architecture ID 10530739)

Pro-MCH domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Pro-MCH super family cl05415
Pro-melanin-concentrating hormone (Pro-MCH); This family consists of several mammalian ...
 83-165 3.42e-53

Pro-melanin-concentrating hormone (Pro-MCH); This family consists of several mammalian pro-melanin-concentrating hormone (Pro-MCH) 1 and 2 proteins. Melanin-concentrating hormone (MCH) is a 19 amino acid cyclic peptide that was first isolated from the pituitary of teleost fish. It is produced from pro-MCH that encodes, in addition to MCH, NEI, and a putative peptide, NGE. In lower vertebrates, MCH acts to regulate skin colour by antagonising the melanin-dispersing actions of small alpha, Greek-melanocyte stimulating hormone (small alpha, Greek-MSH). In mammals, MCH serves as a neuropeptide and is found in many regions of the brain and especially the hypothalamus. It affects many types of behaviours such as appetite, sexual receptivity, aggression, and anxiety. MCH also stimulates the release of luteinising hormone.


The actual alignment was detected with superfamily member pfam05824:

Pssm-ID: 461750  Cd Length: 86  Bit Score: 163.55  E-value: 3.42e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71361678    83 KNTGSKQNLVTHGLPLSLAVK--PYLALKGSVAFPAENGVQNAESTQEKREIGDEENSAKFPIGRRDFDMLRCMLGRVYR 160
Cdd:pfam05824   2 KDIDSRHNFLSHGLPLNLGIKqlPYLALKGSLAFPAENEDQNIESAQERRETGDEENSAKFPVGRRDFDMLRCMLGRVYR 81


                  ....*
gi 71361678   161 PCWQV 165
Cdd:pfam05824  82 PCWQV 86
 
Name Accession Description Interval E-value
Pro-MCH pfam05824
Pro-melanin-concentrating hormone (Pro-MCH); This family consists of several mammalian ...
 83-165 3.42e-53

Pro-melanin-concentrating hormone (Pro-MCH); This family consists of several mammalian pro-melanin-concentrating hormone (Pro-MCH) 1 and 2 proteins. Melanin-concentrating hormone (MCH) is a 19 amino acid cyclic peptide that was first isolated from the pituitary of teleost fish. It is produced from pro-MCH that encodes, in addition to MCH, NEI, and a putative peptide, NGE. In lower vertebrates, MCH acts to regulate skin colour by antagonising the melanin-dispersing actions of small alpha, Greek-melanocyte stimulating hormone (small alpha, Greek-MSH). In mammals, MCH serves as a neuropeptide and is found in many regions of the brain and especially the hypothalamus. It affects many types of behaviours such as appetite, sexual receptivity, aggression, and anxiety. MCH also stimulates the release of luteinising hormone.


Pssm-ID: 461750  Cd Length: 86  Bit Score: 163.55  E-value: 3.42e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71361678    83 KNTGSKQNLVTHGLPLSLAVK--PYLALKGSVAFPAENGVQNAESTQEKREIGDEENSAKFPIGRRDFDMLRCMLGRVYR 160
Cdd:pfam05824   2 KDIDSRHNFLSHGLPLNLGIKqlPYLALKGSLAFPAENEDQNIESAQERRETGDEENSAKFPVGRRDFDMLRCMLGRVYR 81


                  ....*
gi 71361678   161 PCWQV 165
Cdd:pfam05824  82 PCWQV 86
 
Name Accession Description Interval E-value
Pro-MCH pfam05824
Pro-melanin-concentrating hormone (Pro-MCH); This family consists of several mammalian ...
 83-165 3.42e-53

Pro-melanin-concentrating hormone (Pro-MCH); This family consists of several mammalian pro-melanin-concentrating hormone (Pro-MCH) 1 and 2 proteins. Melanin-concentrating hormone (MCH) is a 19 amino acid cyclic peptide that was first isolated from the pituitary of teleost fish. It is produced from pro-MCH that encodes, in addition to MCH, NEI, and a putative peptide, NGE. In lower vertebrates, MCH acts to regulate skin colour by antagonising the melanin-dispersing actions of small alpha, Greek-melanocyte stimulating hormone (small alpha, Greek-MSH). In mammals, MCH serves as a neuropeptide and is found in many regions of the brain and especially the hypothalamus. It affects many types of behaviours such as appetite, sexual receptivity, aggression, and anxiety. MCH also stimulates the release of luteinising hormone.


Pssm-ID: 461750  Cd Length: 86  Bit Score: 163.55  E-value: 3.42e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71361678    83 KNTGSKQNLVTHGLPLSLAVK--PYLALKGSVAFPAENGVQNAESTQEKREIGDEENSAKFPIGRRDFDMLRCMLGRVYR 160
Cdd:pfam05824   2 KDIDSRHNFLSHGLPLNLGIKqlPYLALKGSLAFPAENEDQNIESAQERRETGDEENSAKFPVGRRDFDMLRCMLGRVYR 81


                  ....*
gi 71361678   161 PCWQV 165
Cdd:pfam05824  82 PCWQV 86
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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