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Conserved domains on  [gi|14165410|ref|NP_113685|]
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protocadherin alpha-3 isoform 2 precursor [Homo sapiens]

Protein Classification

protocadherin( domain architecture ID 10550026)

protocadherin may have tightly regulated functions in the development, regionalization, and functional differentiation of the central nervous system

CATH:  2.60.40.60
Gene Ontology:  GO:0007156|GO:0005509
PubMed:  28268172|18430161
SCOP:  4007535

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cadherin_2 pfam08266
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.
 30-111 6.00e-33

Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.


:

Pssm-ID: 462413  Cd Length: 83  Bit Score: 121.87  E-value: 6.00e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14165410    30 QLHYSVSEEAKHGTFVGRIAQDLGLELAELVPRLFRVASKRHGDLLEVNLQNGILFVNSRIDREELCGRSAECSIHLEVI 109
Cdd:pfam08266   1 QIRYSVPEETERGSFVGNLAKDLGLEVGELAARGARVVSKGNKQYFQLNPETGDLLLNEKLDREELCGSTEPCVLHFQVL 80


                  ..
gi 14165410   110 VD 111
Cdd:pfam08266  81 LE 82
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 246-346 1.55e-32

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 121.27  E-value: 1.55e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14165410 246 IYKVRLLENAPNGTLVVTVNATDLDEGVNKDIAYSFntdMSADILSKFHLDPVNGQISVKGNIDFEESKSYEIQVEATDK 325
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSI---VSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                        90       100
                ....*....|....*....|.
gi 14165410 326 GNPPMSDHCTVLLEIVDINDN 346
Cdd:cd11304  78 GGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 459-561 1.74e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 106.63  E-value: 1.74e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14165410 459 EYTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRVgeralSSYVSVHAESGKVYALQPLDHEELELLQFQVSAR 538
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNE-----DGLFSIDPSTGEITTAKPLDREEQSSYTLTVTAT 75

                        90       100
                ....*....|....*....|...
gi 14165410 539 DAGVPPLGSNVTLQVFVLDENDN 561
Cdd:cd11304  76 DGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 354-451 8.33e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 104.70  E-value: 8.33e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14165410 354 SLSLPVLEDSPLSTVIALISVSDRDSGVNGQVTCSLTPHVPFKLVSTFKNYYSLVLDSPLDRESVSAYELVVTARDGGSP 433
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                        90
                ....*....|....*...
gi 14165410 434 SLWATASVSVEVADVNDN 451
Cdd:cd11304  81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 139-238 6.30e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 93.92  E-value: 6.30e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14165410 139 NLFISESRQPGSRFSLEGASDADIGTNSLLTYSL---DSTEYFTLDvkrndeeiKSLG-LVLKKNLNREDTPKHYLLITA 214
Cdd:cd11304   3 EVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIvsgNEDGLFSID--------PSTGeITTAKPLDREEQSSYTLTVTA 74

                        90       100
                ....*....|....*....|....
gi 14165410 215 IDGGKPELTGTTQLKITVLDVNDN 238
Cdd:cd11304  75 TDGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 581-670 3.39e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 88.91  E-value: 3.39e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14165410 581 VPRSVGAGHVVAKVRAVDADSGYNAWLSYELQPGTGGarIPFRVGLYTGEISTTRALDEVDAPRHRLLVLVKDHGEPSLT 660
Cdd:cd11304   6 VPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNED--GLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPLS 83

                        90
                ....*....|
gi 14165410 661 ATATVLVSLV 670
Cdd:cd11304  84 STATVTITVL 93
 
Name Accession Description Interval E-value
Cadherin_2 pfam08266
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.
 30-111 6.00e-33

Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.


Pssm-ID: 462413  Cd Length: 83  Bit Score: 121.87  E-value: 6.00e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14165410    30 QLHYSVSEEAKHGTFVGRIAQDLGLELAELVPRLFRVASKRHGDLLEVNLQNGILFVNSRIDREELCGRSAECSIHLEVI 109
Cdd:pfam08266   1 QIRYSVPEETERGSFVGNLAKDLGLEVGELAARGARVVSKGNKQYFQLNPETGDLLLNEKLDREELCGSTEPCVLHFQVL 80


                  ..
gi 14165410   110 VD 111
Cdd:pfam08266  81 LE 82
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 246-346 1.55e-32

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 121.27  E-value: 1.55e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14165410 246 IYKVRLLENAPNGTLVVTVNATDLDEGVNKDIAYSFntdMSADILSKFHLDPVNGQISVKGNIDFEESKSYEIQVEATDK 325
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSI---VSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                        90       100
                ....*....|....*....|.
gi 14165410 326 GNPPMSDHCTVLLEIVDINDN 346
Cdd:cd11304  78 GGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 459-561 1.74e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 106.63  E-value: 1.74e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14165410 459 EYTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRVgeralSSYVSVHAESGKVYALQPLDHEELELLQFQVSAR 538
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNE-----DGLFSIDPSTGEITTAKPLDREEQSSYTLTVTAT 75

                        90       100
                ....*....|....*....|...
gi 14165410 539 DAGVPPLGSNVTLQVFVLDENDN 561
Cdd:cd11304  76 DGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 354-451 8.33e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 104.70  E-value: 8.33e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14165410 354 SLSLPVLEDSPLSTVIALISVSDRDSGVNGQVTCSLTPHVPFKLVSTFKNYYSLVLDSPLDRESVSAYELVVTARDGGSP 433
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                        90
                ....*....|....*...
gi 14165410 434 SLWATASVSVEVADVNDN 451
Cdd:cd11304  81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 139-238 6.30e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 93.92  E-value: 6.30e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14165410 139 NLFISESRQPGSRFSLEGASDADIGTNSLLTYSL---DSTEYFTLDvkrndeeiKSLG-LVLKKNLNREDTPKHYLLITA 214
Cdd:cd11304   3 EVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIvsgNEDGLFSID--------PSTGeITTAKPLDREEQSSYTLTVTA 74

                        90       100
                ....*....|....*....|....
gi 14165410 215 IDGGKPELTGTTQLKITVLDVNDN 238
Cdd:cd11304  75 TDGGGPPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 265-348 5.67e-22

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 90.49  E-value: 5.67e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14165410    265 NATDLDEGVNKDIAYSFNtdmSADILSKFHLDPVNGQISVKGNIDFEESKSYEIQVEATDKGNPPMSDHCTVLLEIVDIN 344
Cdd:smart00112   1 SATDADSGENGKVTYSIL---SGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVN 77


                   ....
gi 14165410    345 DNVP 348
Cdd:smart00112  78 DNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 581-670 3.39e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 88.91  E-value: 3.39e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14165410 581 VPRSVGAGHVVAKVRAVDADSGYNAWLSYELQPGTGGarIPFRVGLYTGEISTTRALDEVDAPRHRLLVLVKDHGEPSLT 660
Cdd:cd11304   6 VPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNED--GLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPLS 83

                        90
                ....*....|
gi 14165410 661 ATATVLVSLV 670
Cdd:cd11304  84 STATVTITVL 93
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 373-453 1.81e-20

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 86.25  E-value: 1.81e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14165410    373 SVSDRDSGVNGQVTCSLTPHVPFKLVSTFKNYYSLVLDSPLDRESVSAYELVVTARDGGSPSLWATASVSVEVADVNDNA 452
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                   .
gi 14165410    453 P 453
Cdd:smart00112  81 P 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 478-563 2.00e-20

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 86.25  E-value: 2.00e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14165410    478 SARDADAQENALVSYSLVERRVGeralsSYVSVHAESGKVYALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLD 557
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDD-----GLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLD 75


                   ....*.
gi 14165410    558 ENDNAP 563
Cdd:smart00112  76 VNDNAP 81
Cadherin pfam00028
Cadherin domain;
247-340 4.74e-20

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 85.43  E-value: 4.74e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14165410   247 YKVRLLENAPNGTLVVTVNATDLDEGVNKDIAYSFNTDMSADIlskFHLDPVNGQISVKGNIDFEESKSYEIQVEATDKG 326
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGN---FRIDPDTGDISTTKPLDRESIGEYELTVEATDSG 77

                          90
                  ....*....|....
gi 14165410   327 NPPMSDHCTVLLEI 340
Cdd:pfam00028  78 GPPLSSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 157-240 6.01e-20

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 84.71  E-value: 6.01e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14165410    157 ASDADIGTNSLLTYSLDS---TEYFTLDvkRNDEEIkslglVLKKNLNREDTPKHYLLITAIDGGKPELTGTTQLKITVL 233
Cdd:smart00112   2 ATDADSGENGKVTYSILSgndDGLFSID--PETGEI-----TTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVL 74


                   ....*..
gi 14165410    234 DVNDNAP 240
Cdd:smart00112  75 DVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 595-670 4.11e-15

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 70.84  E-value: 4.11e-15
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 14165410    595 RAVDADSGYNAWLSYELQPGTGGarIPFRVGLYTGEISTTRALDEVDAPRHRLLVLVKDHGEPSLTATATVLVSLV 670
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDD--GLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVL 74
Cadherin pfam00028
Cadherin domain;
460-556 2.07e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 69.25  E-value: 2.07e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14165410   460 YTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRVGERalssyVSVHAESGKVYALQPLDHEELELLQFQVSARD 539
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGN-----FRIDPDTGDISTTKPLDRESIGEYELTVEATD 75

                          90
                  ....*....|....*..
gi 14165410   540 AGVPPLGSNVTLQVFVL 556
Cdd:pfam00028  76 SGGPPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
575-669 8.57e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 67.71  E-value: 8.57e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14165410   575 GAVSELVPRsvgaGHVVAKVRAVDADSGYNAWLSYELQPGtgGARIPFRVGLYTGEISTTRALDEVDAPRHRLLVLVKDH 654
Cdd:pfam00028   3 ASVPENAPV----GTEVLTVTATDPDLGPNGRIFYSILGG--GPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDS 76

                          90
                  ....*....|....*
gi 14165410   655 GEPSLTATATVLVSL 669
Cdd:pfam00028  77 GGPPLSSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
359-445 5.57e-13

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 65.40  E-value: 5.57e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14165410   359 VLEDSPLSTVIALISVSDRDSGVNGQVTCSLTPHVPFKLVSTFKNYYSLVLDSPLDRESVSAYELVVTARDGGSPSLWAT 438
Cdd:pfam00028   5 VPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPLSST 84


                  ....*..
gi 14165410   439 ASVSVEV 445
Cdd:pfam00028  85 ATVTITV 91
Cadherin pfam00028
Cadherin domain;
142-233 6.23e-11

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 59.62  E-value: 6.23e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14165410   142 ISESRQPGSRFSLEGASDADIGTNSLLTYSLDSTEY---FTLDVKRNDeeikslgLVLKKNLNREDTPKHYLLITAIDGG 218
Cdd:pfam00028   5 VPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPggnFRIDPDTGD-------ISTTKPLDRESIGEYELTVEATDSG 77

                          90
                  ....*....|....*
gi 14165410   219 KPELTGTTQLKITVL 233
Cdd:pfam00028  78 GPPLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 32-129 1.25e-10

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 58.86  E-value: 1.25e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14165410  32 HYSVSEEAKHGTFVGRI-AQDLGLELAELVprLFRVASKRHGDLLEVNLQNGILFVNSRIDREELcgrsaeCSIHLEVIV 110
Cdd:cd11304   3 EVSVPENAPPGTVVLTVsATDPDSGENGEV--TYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQ------SSYTLTVTA 74

                        90       100
                ....*....|....*....|....
gi 14165410 111 -DRPLQVF----HVEVEVKDINDN 129
Cdd:cd11304  75 tDGGGPPLsstaTVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 64-131 1.06e-05

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 44.26  E-value: 1.06e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 14165410     64 FRVASKRHGDLLEVNLQNGILFVNSRIDREELCgrsaecSIHLEVIV----DRPLQVF-HVEVEVKDINDNAP 131
Cdd:smart00112  15 YSILSGNDDGLFSIDPETGEITTTKPLDREEQP------EYTLTVEAtdggGPPLSSTaTVTITVLDVNDNAP 81
 
Name Accession Description Interval E-value
Cadherin_2 pfam08266
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.
 30-111 6.00e-33

Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.


Pssm-ID: 462413  Cd Length: 83  Bit Score: 121.87  E-value: 6.00e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14165410    30 QLHYSVSEEAKHGTFVGRIAQDLGLELAELVPRLFRVASKRHGDLLEVNLQNGILFVNSRIDREELCGRSAECSIHLEVI 109
Cdd:pfam08266   1 QIRYSVPEETERGSFVGNLAKDLGLEVGELAARGARVVSKGNKQYFQLNPETGDLLLNEKLDREELCGSTEPCVLHFQVL 80


                  ..
gi 14165410   110 VD 111
Cdd:pfam08266  81 LE 82
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 246-346 1.55e-32

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 121.27  E-value: 1.55e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14165410 246 IYKVRLLENAPNGTLVVTVNATDLDEGVNKDIAYSFntdMSADILSKFHLDPVNGQISVKGNIDFEESKSYEIQVEATDK 325
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSI---VSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                        90       100
                ....*....|....*....|.
gi 14165410 326 GNPPMSDHCTVLLEIVDINDN 346
Cdd:cd11304  78 GGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 459-561 1.74e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 106.63  E-value: 1.74e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14165410 459 EYTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRVgeralSSYVSVHAESGKVYALQPLDHEELELLQFQVSAR 538
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNE-----DGLFSIDPSTGEITTAKPLDREEQSSYTLTVTAT 75

                        90       100
                ....*....|....*....|...
gi 14165410 539 DAGVPPLGSNVTLQVFVLDENDN 561
Cdd:cd11304  76 DGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 354-451 8.33e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 104.70  E-value: 8.33e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14165410 354 SLSLPVLEDSPLSTVIALISVSDRDSGVNGQVTCSLTPHVPFKLVSTFKNYYSLVLDSPLDRESVSAYELVVTARDGGSP 433
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                        90
                ....*....|....*...
gi 14165410 434 SLWATASVSVEVADVNDN 451
Cdd:cd11304  81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 139-238 6.30e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 93.92  E-value: 6.30e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14165410 139 NLFISESRQPGSRFSLEGASDADIGTNSLLTYSL---DSTEYFTLDvkrndeeiKSLG-LVLKKNLNREDTPKHYLLITA 214
Cdd:cd11304   3 EVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIvsgNEDGLFSID--------PSTGeITTAKPLDREEQSSYTLTVTA 74

                        90       100
                ....*....|....*....|....
gi 14165410 215 IDGGKPELTGTTQLKITVLDVNDN 238
Cdd:cd11304  75 TDGGGPPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 265-348 5.67e-22

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 90.49  E-value: 5.67e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14165410    265 NATDLDEGVNKDIAYSFNtdmSADILSKFHLDPVNGQISVKGNIDFEESKSYEIQVEATDKGNPPMSDHCTVLLEIVDIN 344
Cdd:smart00112   1 SATDADSGENGKVTYSIL---SGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVN 77


                   ....
gi 14165410    345 DNVP 348
Cdd:smart00112  78 DNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 581-670 3.39e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 88.91  E-value: 3.39e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14165410 581 VPRSVGAGHVVAKVRAVDADSGYNAWLSYELQPGTGGarIPFRVGLYTGEISTTRALDEVDAPRHRLLVLVKDHGEPSLT 660
Cdd:cd11304   6 VPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNED--GLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPLS 83

                        90
                ....*....|
gi 14165410 661 ATATVLVSLV 670
Cdd:cd11304  84 STATVTITVL 93
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 373-453 1.81e-20

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 86.25  E-value: 1.81e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14165410    373 SVSDRDSGVNGQVTCSLTPHVPFKLVSTFKNYYSLVLDSPLDRESVSAYELVVTARDGGSPSLWATASVSVEVADVNDNA 452
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                   .
gi 14165410    453 P 453
Cdd:smart00112  81 P 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 478-563 2.00e-20

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 86.25  E-value: 2.00e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14165410    478 SARDADAQENALVSYSLVERRVGeralsSYVSVHAESGKVYALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLD 557
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDD-----GLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLD 75


                   ....*.
gi 14165410    558 ENDNAP 563
Cdd:smart00112  76 VNDNAP 81
Cadherin pfam00028
Cadherin domain;
247-340 4.74e-20

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 85.43  E-value: 4.74e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14165410   247 YKVRLLENAPNGTLVVTVNATDLDEGVNKDIAYSFNTDMSADIlskFHLDPVNGQISVKGNIDFEESKSYEIQVEATDKG 326
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGN---FRIDPDTGDISTTKPLDRESIGEYELTVEATDSG 77

                          90
                  ....*....|....
gi 14165410   327 NPPMSDHCTVLLEI 340
Cdd:pfam00028  78 GPPLSSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 157-240 6.01e-20

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 84.71  E-value: 6.01e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14165410    157 ASDADIGTNSLLTYSLDS---TEYFTLDvkRNDEEIkslglVLKKNLNREDTPKHYLLITAIDGGKPELTGTTQLKITVL 233
Cdd:smart00112   2 ATDADSGENGKVTYSILSgndDGLFSID--PETGEI-----TTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVL 74


                   ....*..
gi 14165410    234 DVNDNAP 240
Cdd:smart00112  75 DVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 595-670 4.11e-15

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 70.84  E-value: 4.11e-15
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 14165410    595 RAVDADSGYNAWLSYELQPGTGGarIPFRVGLYTGEISTTRALDEVDAPRHRLLVLVKDHGEPSLTATATVLVSLV 670
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDD--GLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVL 74
Cadherin pfam00028
Cadherin domain;
460-556 2.07e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 69.25  E-value: 2.07e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14165410   460 YTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRVGERalssyVSVHAESGKVYALQPLDHEELELLQFQVSARD 539
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGN-----FRIDPDTGDISTTKPLDRESIGEYELTVEATD 75

                          90
                  ....*....|....*..
gi 14165410   540 AGVPPLGSNVTLQVFVL 556
Cdd:pfam00028  76 SGGPPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
575-669 8.57e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 67.71  E-value: 8.57e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14165410   575 GAVSELVPRsvgaGHVVAKVRAVDADSGYNAWLSYELQPGtgGARIPFRVGLYTGEISTTRALDEVDAPRHRLLVLVKDH 654
Cdd:pfam00028   3 ASVPENAPV----GTEVLTVTATDPDLGPNGRIFYSILGG--GPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDS 76

                          90
                  ....*....|....*
gi 14165410   655 GEPSLTATATVLVSL 669
Cdd:pfam00028  77 GGPPLSSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
359-445 5.57e-13

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 65.40  E-value: 5.57e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14165410   359 VLEDSPLSTVIALISVSDRDSGVNGQVTCSLTPHVPFKLVSTFKNYYSLVLDSPLDRESVSAYELVVTARDGGSPSLWAT 438
Cdd:pfam00028   5 VPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPLSST 84


                  ....*..
gi 14165410   439 ASVSVEV 445
Cdd:pfam00028  85 ATVTITV 91
Cadherin pfam00028
Cadherin domain;
142-233 6.23e-11

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 59.62  E-value: 6.23e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14165410   142 ISESRQPGSRFSLEGASDADIGTNSLLTYSLDSTEY---FTLDVKRNDeeikslgLVLKKNLNREDTPKHYLLITAIDGG 218
Cdd:pfam00028   5 VPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPggnFRIDPDTGD-------ISTTKPLDRESIGEYELTVEATDSG 77

                          90
                  ....*....|....*
gi 14165410   219 KPELTGTTQLKITVL 233
Cdd:pfam00028  78 GPPLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 32-129 1.25e-10

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 58.86  E-value: 1.25e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14165410  32 HYSVSEEAKHGTFVGRI-AQDLGLELAELVprLFRVASKRHGDLLEVNLQNGILFVNSRIDREELcgrsaeCSIHLEVIV 110
Cdd:cd11304   3 EVSVPENAPPGTVVLTVsATDPDSGENGEV--TYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQ------SSYTLTVTA 74

                        90       100
                ....*....|....*....|....
gi 14165410 111 -DRPLQVF----HVEVEVKDINDN 129
Cdd:cd11304  75 tDGGGPPLsstaTVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 64-131 1.06e-05

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 44.26  E-value: 1.06e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 14165410     64 FRVASKRHGDLLEVNLQNGILFVNSRIDREELCgrsaecSIHLEVIV----DRPLQVF-HVEVEVKDINDNAP 131
Cdd:smart00112  15 YSILSGNDDGLFSIDPETGEITTTKPLDREEQP------EYTLTVEAtdggGPPLSSTaTVTITVLDVNDNAP 81
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 33-129 1.06e-04

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 41.95  E-value: 1.06e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14165410  33 YSVSEEAKHGTFVGRIAQDLGLELAELVPRLFRVASKRHGdLLEVNLQNGILFVNSRIDREELcgrsaeCSIHLEVIVDR 112
Cdd:cd00031   4 GSAVEGRSRGSFRVSIPTDLIASSGEIIKISAAGKEALPS-WLHWEPHSGILEGLEKLDREDK------GVHYISVSAAS 76

                        90       100
                ....*....|....*....|..
gi 14165410 113 -----PLQVFHVEVEVKDINDN 129
Cdd:cd00031  77 lganvPQTSSVFSIEVYDENDN 98
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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