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Conserved domains on  [gi|49574534|ref|NP_116171|]
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hepatitis A virus cellular receptor 2 precursor [Homo sapiens]

Protein Classification

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List of domain hits

 Name Accession Description Interval E-value
IgV_TIM-3_like cd20982
Immunoglobulin Variable (IgV) domain of T cell Immunoglobulin Domain and Mucin Domain 3 (Tim-3) ...
 24-129 3.03e-69

Immunoglobulin Variable (IgV) domain of T cell Immunoglobulin Domain and Mucin Domain 3 (Tim-3), and similar domains; The members here are composed of the immunoglobulin variable (IgV) domain of T cell immunoglobulin domain and mucin domain 3 (Tim-3; also known as Hepatitis A virus cellular receptor 2 (HAVcr-2) and Cluster of Differentiation 366 (CD366)) and similar proteins. TIM-3 is a checkpoint inhibitor in immune responses to tumors, as well as involved in chronic viral infections. Thus, Tim-3 has emerged as one of most promising immune checkpoint targets for cancer immunotherapy. Tim-3 is highly expressed on Th1 lymphocytes and CD11b(+) macrophages and is upregulated on activated T and myeloid cells. TIM-3 regulates macrophage, activation and inhibits Th1 mediated immune responses to promote immunological tolerance. There are three TIM family members in humans (TIM-1, TIM-3, and TIM-4) and eight members in mice (TIM-1 to TIM-8). The IgV domain of human TIM-3 has been shown to bind ligands such as carcinoembryonic antigen cell adhesion molecule 1 (CEACAM1), high mobility group protein B1 (HMGB1)and galectin-9 (GAL9). The binding of GAL9 to TIM-3 can negatively regulate Th1 immune response, enhance immune tolerance and inhibit anti#tumor immunity. Dysregulation of the TIM-3/GAL9 pathway is implicated in numerous chronic autoimmune diseases, such as multiple sclerosis and systemic lupus erythematosus.


:

Pssm-ID: 409574  Cd Length: 107  Bit Score: 210.01  E-value: 3.03e-69
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49574534  24 VEYRAEVGQNAYLPCFYTPAAPGNLVPVCWGKGACPVFECGNVVLRTDERDVNYWTS-RYWLNGDFRKGDVSLTIENVTL 102
Cdd:cd20982   1 VEYRAEVGHNAYLPCSYTTAAPGNLVPVCWGKGACPVSYCGNVLLRTDERDVTYQKSsRYQLKGDFSKGDVSLTIENVTL 80

                        90       100
                ....*....|....*....|....*..
gi 49574534 103 ADSGIYCCRIQIPGIMNDEKFNLKLVI 129
Cdd:cd20982  81 ADSGIYCCRIQIPGIMNDEKFNLKLVI 107
 
Name Accession Description Interval E-value
IgV_TIM-3_like cd20982
Immunoglobulin Variable (IgV) domain of T cell Immunoglobulin Domain and Mucin Domain 3 (Tim-3) ...
 24-129 3.03e-69

Immunoglobulin Variable (IgV) domain of T cell Immunoglobulin Domain and Mucin Domain 3 (Tim-3), and similar domains; The members here are composed of the immunoglobulin variable (IgV) domain of T cell immunoglobulin domain and mucin domain 3 (Tim-3; also known as Hepatitis A virus cellular receptor 2 (HAVcr-2) and Cluster of Differentiation 366 (CD366)) and similar proteins. TIM-3 is a checkpoint inhibitor in immune responses to tumors, as well as involved in chronic viral infections. Thus, Tim-3 has emerged as one of most promising immune checkpoint targets for cancer immunotherapy. Tim-3 is highly expressed on Th1 lymphocytes and CD11b(+) macrophages and is upregulated on activated T and myeloid cells. TIM-3 regulates macrophage, activation and inhibits Th1 mediated immune responses to promote immunological tolerance. There are three TIM family members in humans (TIM-1, TIM-3, and TIM-4) and eight members in mice (TIM-1 to TIM-8). The IgV domain of human TIM-3 has been shown to bind ligands such as carcinoembryonic antigen cell adhesion molecule 1 (CEACAM1), high mobility group protein B1 (HMGB1)and galectin-9 (GAL9). The binding of GAL9 to TIM-3 can negatively regulate Th1 immune response, enhance immune tolerance and inhibit anti#tumor immunity. Dysregulation of the TIM-3/GAL9 pathway is implicated in numerous chronic autoimmune diseases, such as multiple sclerosis and systemic lupus erythematosus.


Pssm-ID: 409574  Cd Length: 107  Bit Score: 210.01  E-value: 3.03e-69
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49574534  24 VEYRAEVGQNAYLPCFYTPAAPGNLVPVCWGKGACPVFECGNVVLRTDERDVNYWTS-RYWLNGDFRKGDVSLTIENVTL 102
Cdd:cd20982   1 VEYRAEVGHNAYLPCSYTTAAPGNLVPVCWGKGACPVSYCGNVLLRTDERDVTYQKSsRYQLKGDFSKGDVSLTIENVTL 80

                        90       100
                ....*....|....*....|....*..
gi 49574534 103 ADSGIYCCRIQIPGIMNDEKFNLKLVI 129
Cdd:cd20982  81 ADSGIYCCRIQIPGIMNDEKFNLKLVI 107
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 28-122 6.35e-13

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 64.02  E-value: 6.35e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49574534    28 AEVGQNAYLPCFYTPAAPGNLVPVCWGKGACPVfECGNVVLRTDERDVNYWTS-RYWLNGDFRKGDVSLTIENVTLADSG 106
Cdd:pfam07686   8 VALGGSVTLPCTYSSSMSEASTSVYWYRQPPGK-GPTFLIAYYSNGSEEGVKKgRFSGRGDPSNGDGSLTIQNLTLSDSG 86

                          90
                  ....*....|....*.
gi 49574534   107 IYCCRIQIPGIMNDEK 122
Cdd:pfam07686  87 TYTCAVIPSGEGVFGK 102
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 26-126 2.45e-04

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 39.03  E-value: 2.45e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49574534     26 YRAEVGQNAYLPCfytpAAPGNLVPVCWgkgacpvfecgnvVLRTDERDVNYwTSRYwlNGDFRKGDVSLTIENVTLADS 105
Cdd:smart00410   4 VTVKEGESVTLSC----EASGSPPPEVT-------------WYKQGGKLLAE-SGRF--SVSRSGSTSTLTISNVTPEDS 63

                           90       100
                   ....*....|....*....|.
gi 49574534    106 GIYCCRIQIPGIMNDEKFNLK 126
Cdd:smart00410  64 GTYTCAATNSSGSASSGTTLT 84
 
Name Accession Description Interval E-value
IgV_TIM-3_like cd20982
Immunoglobulin Variable (IgV) domain of T cell Immunoglobulin Domain and Mucin Domain 3 (Tim-3) ...
 24-129 3.03e-69

Immunoglobulin Variable (IgV) domain of T cell Immunoglobulin Domain and Mucin Domain 3 (Tim-3), and similar domains; The members here are composed of the immunoglobulin variable (IgV) domain of T cell immunoglobulin domain and mucin domain 3 (Tim-3; also known as Hepatitis A virus cellular receptor 2 (HAVcr-2) and Cluster of Differentiation 366 (CD366)) and similar proteins. TIM-3 is a checkpoint inhibitor in immune responses to tumors, as well as involved in chronic viral infections. Thus, Tim-3 has emerged as one of most promising immune checkpoint targets for cancer immunotherapy. Tim-3 is highly expressed on Th1 lymphocytes and CD11b(+) macrophages and is upregulated on activated T and myeloid cells. TIM-3 regulates macrophage, activation and inhibits Th1 mediated immune responses to promote immunological tolerance. There are three TIM family members in humans (TIM-1, TIM-3, and TIM-4) and eight members in mice (TIM-1 to TIM-8). The IgV domain of human TIM-3 has been shown to bind ligands such as carcinoembryonic antigen cell adhesion molecule 1 (CEACAM1), high mobility group protein B1 (HMGB1)and galectin-9 (GAL9). The binding of GAL9 to TIM-3 can negatively regulate Th1 immune response, enhance immune tolerance and inhibit anti#tumor immunity. Dysregulation of the TIM-3/GAL9 pathway is implicated in numerous chronic autoimmune diseases, such as multiple sclerosis and systemic lupus erythematosus.


Pssm-ID: 409574  Cd Length: 107  Bit Score: 210.01  E-value: 3.03e-69
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49574534  24 VEYRAEVGQNAYLPCFYTPAAPGNLVPVCWGKGACPVFECGNVVLRTDERDVNYWTS-RYWLNGDFRKGDVSLTIENVTL 102
Cdd:cd20982   1 VEYRAEVGHNAYLPCSYTTAAPGNLVPVCWGKGACPVSYCGNVLLRTDERDVTYQKSsRYQLKGDFSKGDVSLTIENVTL 80

                        90       100
                ....*....|....*....|....*..
gi 49574534 103 ADSGIYCCRIQIPGIMNDEKFNLKLVI 129
Cdd:cd20982  81 ADSGIYCCRIQIPGIMNDEKFNLKLVI 107
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 28-122 6.35e-13

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 64.02  E-value: 6.35e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49574534    28 AEVGQNAYLPCFYTPAAPGNLVPVCWGKGACPVfECGNVVLRTDERDVNYWTS-RYWLNGDFRKGDVSLTIENVTLADSG 106
Cdd:pfam07686   8 VALGGSVTLPCTYSSSMSEASTSVYWYRQPPGK-GPTFLIAYYSNGSEEGVKKgRFSGRGDPSNGDGSLTIQNLTLSDSG 86

                          90
                  ....*....|....*.
gi 49574534   107 IYCCRIQIPGIMNDEK 122
Cdd:pfam07686  87 TYTCAVIPSGEGVFGK 102
IgV_CAR_like cd20960
Immunoglobulin Variable (V) domain of the Coxsackievirus and Adenovirus Receptor (CAR), and ...
 21-113 1.27e-04

Immunoglobulin Variable (V) domain of the Coxsackievirus and Adenovirus Receptor (CAR), and similar proteins; The members here are composed of the Variable (V) domain of the Coxsackievirus and Adenovirus Receptor (CAR), and similar proteins. CAR, which is encoded by human CXADR gene, is a cell adhesion molecule of the Immunoglobulin (Ig) superfamily. The CAR acts as a type I membrane receptor for group B1-B6 coxsackie viruses and subgroup C adenoviruses. For instance, adenovirus interacts with the coxsackievirus and adenovirus receptor to enter epithelial airway cells. The CAR is also shown to be involved in physiological processes such as neuronal and heart development, epithelial tight junction integrity, and tumor suppression. The CAR is a component of the epithelial apical junction complex that may function as a homophilic cell adhesion molecule and is essential for tight junction integrity. The CAR is also involved in transepithelial migration of leukocytes through adhesive interactions with JAML a transmembrane protein of the plasma membrane of leukocytes. The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. The CAR is composed of one V-set and one C2-set Ig module, a single transmembrane helix, and an intracellular domain. This group belongs to the V-set of IgSF domains, having A, B, E and D strands in one beta-sheet and A', G, F, C, C' and C" in the other


Pssm-ID: 409552  Cd Length: 114  Bit Score: 40.90  E-value: 1.27e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49574534  21 SSEVEYRAEVGQNAYLPCFYTPAAPGN--------LVPVCWGKGACPVFECGNVV--LRTDERdvnywtSRYWLNGDFRK 90
Cdd:cd20960   5 SAQTEIKKVAGENVTLPCHHQLGLEDQgtldiewlLLPSDKVEKVVITYSGDRVYnhYYPALK------GRVAFTSNDLS 78

                        90       100
                ....*....|....*....|...
gi 49574534  91 GDVSLTIENVTLADSGIYCCRIQ 113
Cdd:cd20960  79 GDASLNISNLKLSDTGTYQCKVK 101
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 26-126 2.45e-04

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 39.03  E-value: 2.45e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49574534     26 YRAEVGQNAYLPCfytpAAPGNLVPVCWgkgacpvfecgnvVLRTDERDVNYwTSRYwlNGDFRKGDVSLTIENVTLADS 105
Cdd:smart00410   4 VTVKEGESVTLSC----EASGSPPPEVT-------------WYKQGGKLLAE-SGRF--SVSRSGSTSTLTISNVTPEDS 63

                           90       100
                   ....*....|....*....|.
gi 49574534    106 GIYCCRIQIPGIMNDEKFNLK 126
Cdd:smart00410  64 GTYTCAATNSSGSASSGTTLT 84
IgV_1_PVR_like cd05718
First immunoglobulin variable (IgV) domain of poliovirus receptor (PVR, also known as CD155 ...
 23-112 1.76e-03

First immunoglobulin variable (IgV) domain of poliovirus receptor (PVR, also known as CD155 and necl-5), and similar domains; The members here are composed of the first immunoglobulin (Ig) domain of poliovirus receptor (PVR, also known as CD155 and nectin-like protein 5 (necl-5)). Poliovirus (PV) binds to its cellular receptor (PVR/CD155) to initiate infection. CD155 is a membrane-anchored, single-span glycoprotein; its extracellular region has three Ig-like domains. There are four different isotypes of CD155 (referred to as alpha, beta, gamma, and delta), that result from alternate splicing of the CD155 mRNA, and have identical extracellular domains. CD155-beta and CD155-gamma are secreted; CD155-alpha and CD155-delta are membrane-bound and function as PV receptors. The virus recognition site is contained in the amino-terminal domain, D1. Having the virus attachment site on the receptor distal from the plasma membrane may be important for successful initiation of infection of cells by the virus. CD155 binds in the poliovirus "canyon" with a footprint similar to that of the intercellular adhesion molecule-1 receptor on human rhinoviruses. This group also includes the first Ig-like domain of nectin-1 (also known as poliovirus receptor related protein(PVRL)1; CD111), nectin-3 (also known as PVRL 3), nectin-4 (also known as PVRL4; LNIR receptor)and DNAX accessory molecule 1 (DNAM-1; CD226).


Pssm-ID: 409383  Cd Length: 113  Bit Score: 37.43  E-value: 1.76e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49574534  23 EVEYRAEVGQNAYLPCFYTPAAPGNLVPVCWGK------GACPVF--ECGNVVLRTDERDVNYWTSRYWLNgdfrkgDVS 94
Cdd:cd05718   6 PTEVTGFLGGSVTLPCSLTSPGTTKITQVTWMKigagssQNVAVFhpQYGPSVPNPYAERVEFLAARLGLR------NAT 79

                        90
                ....*....|....*...
gi 49574534  95 LTIENVTLADSGIYCCRI 112
Cdd:cd05718  80 LRIRNLRVEDEGNYICEF 97
IgV_P0-like cd05715
Immunoglobulin (Ig)-like domain of protein zero (P0) and similar proteins; The members here ...
 28-115 1.81e-03

Immunoglobulin (Ig)-like domain of protein zero (P0) and similar proteins; The members here are composed of the immunoglobulin (Ig) domain of protein zero (P0), a myelin membrane adhesion molecule. P0 accounts for over 50% of the total protein in peripheral nervous system (PNS) myelin. P0 is a single-pass transmembrane glycoprotein with a highly basic intracellular domain and an extracellular Ig domain. The extracellular domain of P0 (P0-ED) is similar to the Ig variable domain, carrying one acceptor sequence for N-linked glycosylation. P0 plays a role in membrane adhesion in the spiral wraps of the myelin sheath. The intracellular domain is thought to mediate membrane apposition of the cytoplasmic faces and may, through electrostatic interactions, interact directly with lipid headgroups. It is thought that homophilic interactions of the P0 extracellular domain mediate membrane juxtaposition in the extracellular space of PNS myelin. This group also contains the Ig domain of sodium channel subunit beta-2 (SCN2B), and of epithelial V-like antigen 1 (EVA). EVA, also known as myelin protein zero-like 2, is an adhesion molecule, which may play a role in structural organization of the thymus and early lymphocyte development. SCN2B subunits play a role in determining sodium channel density and function in neurons,and in control of electrical excitability in the brain.


Pssm-ID: 409380  Cd Length: 117  Bit Score: 37.41  E-value: 1.81e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49574534  28 AEVGQNAYLPCFYTPAAP-GNLVPVCWG----KGACPVF----ECGNVVLRTDERdvnyWTSRYWLNGDFRKGDVSLTIE 98
Cdd:cd05715  11 VLNGSDVRLTCTFTSCYTvGDAFSVTWTyqpeGGNTTESmfhySKGKPYILKVGR----FKDRVSWAGNPSKKDASIVIS 86

                        90
                ....*....|....*..
gi 49574534  99 NVTLADSGIYCCRIQIP 115
Cdd:cd05715  87 NLQFSDNGTYTCDVKNP 103
IGv smart00406
Immunoglobulin V-Type;
80-110 2.15e-03

Immunoglobulin V-Type;


Pssm-ID: 214650  Cd Length: 81  Bit Score: 36.59  E-value: 2.15e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 49574534     80 SRYWLNGDFRKGDVSLTIENVTLADSGIYCC 110
Cdd:smart00406  49 GRFTISKDTSKNDVSLTISNLRVEDTGTYYC 79
IgV_1_DNAM-1_like cd05889
First immunoglobulin variable (IgV) domain of DNAX accessory molecule 1, and similar domains; ...
 74-113 5.01e-03

First immunoglobulin variable (IgV) domain of DNAX accessory molecule 1, and similar domains; The members here are composed of the first immunoglobulin (Ig) domain of DNAX accessory molecule 1 (DNAM-1, also known as CD226). DNAM-1 is a transmembrane protein having two Ig-like domains. It is an adhesion molecule which plays a part in tumor-directed cytotoxicity and adhesion in natural killer (NK) cells and T lymphocytes. It has been shown to regulate the NK cell killing of several tumor types, including myeloma cells and ovarian carcinoma cells. DNAM-1 interacts specifically with poliovirus receptor (PVR; CD155) and nectin -2 (CD211), other members of the Ig superfamily. DNAM-1 is expressed in most peripheral T cells, NK cells, monocytes and a subset of B lymphocytes.


Pssm-ID: 409472  Cd Length: 111  Bit Score: 35.99  E-value: 5.01e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 49574534  74 DVNYWTSRYWLNGDFRKGDVSLTIENVTLADSGIYCCRIQ 113
Cdd:cd05889  56 RKPYAGRVYFLNSTMASNNMSLSFRNASEDDVGYYSCSLY 95
Ig cd00096
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 85-111 6.98e-03

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409353 [Multi-domain]  Cd Length: 70  Bit Score: 34.61  E-value: 6.98e-03
                        10        20
                ....*....|....*....|....*..
gi 49574534  85 NGDFRKGDVSLTIENVTLADSGIYCCR 111
Cdd:cd00096  31 SRRSELGNGTLTISNVTLEDSGTYTCV 57
IgV_VISTA cd20980
Immunoglobulin variable (IgV) domain of V-domain immunoglobulin suppressor of T cell ...
 91-110 8.15e-03

Immunoglobulin variable (IgV) domain of V-domain immunoglobulin suppressor of T cell activation (VISTA); The members here are composed of the immunoglobulin variable (IgV) domain of V-domain immunoglobulin suppressor of T cell activation (VISTA; also known as B7-H5, PD-1H, Gi24, Dies1, SISP1 and DD1alpha). VISTA is an immune checkpoint protein involved in the regulation of T cell activity and inhibits the T cell response against cancer. VISTA is a type I transmembrane protein with a single IgV domain with sequence homology to the IgV domains of the members of B7 family. VISTA is the only B7 family member that lacks an IgC domain. VISTA is primarily expressed in white blood cells and its transcription is partially controlled by p53. Similar to PD-1/PD-L1 and CTLA-4, a blockade of VISTA promotes tumor clearance by the immune system. Unlike the B7 family members, VISTA contains 10 beta-strands, instead of the nine that typically comprises of an IgV fold. Moreover, human VISTA contains the 21-residue extended loop between stands C and C', which does not align with any B7 family structure.


Pssm-ID: 409572  Cd Length: 147  Bit Score: 36.05  E-value: 8.15e-03
                        10        20
                ....*....|....*....|
gi 49574534  91 GDVSLTIENVTLADSGIYCC 110
Cdd:cd20980  93 GNFSITMRNLTLLDSGLYCC 112
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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