|
Name |
Accession |
Description |
Interval |
E-value |
| SrmB |
COG0513 |
Superfamily II DNA and RNA helicase [Replication, recombination and repair]; |
8-399 |
6.77e-109 |
|
Superfamily II DNA and RNA helicase [Replication, recombination and repair];
Pssm-ID: 440279 [Multi-domain] Cd Length: 420 Bit Score: 333.65 E-value: 6.77e-109
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 8 DNLGFSllPWIRTGLDVMGFETMTPVQASTIPMLAGNKDVVVDSVTGSGKTAAFVIPVLEKVVKEEANTSKfkkahfhSL 87
Cdd:COG0513 5 ADLGLS--PPLLKALAELGYTTPTPIQAQAIPLILAGRDVLGQAQTGTGKTAAFLLPLLQRLDPSRPRAPQ-------AL 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 88 IIAPTRELSRQIESVVLSFLEHYPsdlfpIKCQLLVG-TNEATVRDDvsnfLRNRPQILIGTPGRVLDFLQMPAVKTSAC 166
Cdd:COG0513 76 ILAPTRELALQVAEELRKLAKYLG-----LRVATVYGgVSIGRQIRA----LKRGVDIVVATPGRLLDLIERGALDLSGV 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 167 SMVVMDEADRLLDMSFIKDTEKILRLLPKQRRTGLFSATMRSAGSDIFKTGLRNPVRITVNSKNQAPSSLKLNYCVVNPA 246
Cdd:COG0513 147 ETLVLDEADRMLDMGFIEDIERILKLLPKERQTLLFSATMPPEIRKLAKRYLKNPVRIEVAPENATAETIEQRYYLVDKR 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 247 EKLQLLVSILNNYKFKKCIVYFPTCVSVSYFYsfiQYLGKRNILVNeveifSLHGKLQTSARTKTLTAFTDSlSNSVLFT 326
Cdd:COG0513 227 DKLELLRRLLRDEDPERAIVFCNTKRGADRLA---EKLQKRGISAA-----ALHGDLSQGQRERALDAFRNG-KIRVLVA 297
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 14318521 327 TDVAARGIDIPDVDLVIQLDPPTNTDMFMHRCGRTGRANRVGKAITFLNEGREEDFIPFMQVKNVELEELDLE 399
Cdd:COG0513 298 TDVAARGIDIDDVSHVINYDLPEDPEDYVHRIGRTGRAGAEGTAISLVTPDERRLLRAIEKLIGQKIEEEELP 370
|
|
| DEADc_DDX55 |
cd17960 |
DEAD-box helicase domain of DEAD box protein 55; DDX55 is a member of the DEAD-box helicases, ... |
18-225 |
4.51e-102 |
|
DEAD-box helicase domain of DEAD box protein 55; DDX55 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350718 [Multi-domain] Cd Length: 202 Bit Score: 307.97 E-value: 4.51e-102
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 18 IRTGLDVMGFETMTPVQASTIPMLAGNKDVVVDSVTGSGKTAAFVIPVLEKVVKEEANtskFKKAHFHSLIIAPTRELSR 97
Cdd:cd17960 1 ILDVVAELGFTSMTPVQAATIPLFLSNKDVVVEAVTGSGKTLAFLIPVLEILLKRKAN---LKKGQVGALIISPTRELAT 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 98 QIESVVLSFLEHYpsdLFPIKCQLLVGTNEATVrdDVSNFLRNRPQILIGTPGRVLDFLQMPA--VKTSACSMVVMDEAD 175
Cdd:cd17960 78 QIYEVLQSFLEHH---LPKLKCQLLIGGTNVEE--DVKKFKRNGPNILVGTPGRLEELLSRKAdkVKVKSLEVLVLDEAD 152
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 14318521 176 RLLDMSFIKDTEKILRLLPKQRRTGLFSATMRSAGSDIFKTGLRNPVRIT 225
Cdd:cd17960 153 RLLDLGFEADLNRILSKLPKQRRTGLFSATQTDAVEELIKAGLRNPVRVV 202
|
|
| DEADc |
cd00268 |
DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family ... |
18-225 |
7.97e-70 |
|
DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350669 [Multi-domain] Cd Length: 196 Bit Score: 224.24 E-value: 7.97e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 18 IRTGLDVMGFETMTPVQASTIPMLAGNKDVVVDSVTGSGKTAAFVIPVLEKVVKEEANTSKFKKAhfhsLIIAPTRELSR 97
Cdd:cd00268 1 LLKALKKLGFEKPTPIQAQAIPLILSGRDVIGQAQTGSGKTLAFLLPILEKLLPEPKKKGRGPQA----LVLAPTRELAM 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 98 QIESVVLSFLEHYPsdlfpIKCQLLVGtneATVRDDVSNFLRNRPQILIGTPGRVLDFLQMPAVKTSACSMVVMDEADRL 177
Cdd:cd00268 77 QIAEVARKLGKGTG-----LKVAAIYG---GAPIKKQIEALKKGPDIVVGTPGRLLDLIERGKLDLSNVKYLVLDEADRM 148
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 14318521 178 LDMSFIKDTEKILRLLPKQRRTGLFSATMRSAGSDIFKTGLRNPVRIT 225
Cdd:cd00268 149 LDMGFEEDVEKILSALPKDRQTLLFSATLPEEVKELAKKFLKNPVRIE 196
|
|
| PRK11776 |
PRK11776 |
ATP-dependent RNA helicase DbpA; Provisional |
20-376 |
6.30e-67 |
|
ATP-dependent RNA helicase DbpA; Provisional
Pssm-ID: 236977 [Multi-domain] Cd Length: 460 Bit Score: 225.45 E-value: 6.30e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 20 TGLDVMGFETMTPVQASTIP-MLAGnKDVVVDSVTGSGKTAAFVIPVLEKVvkeeaNTSKFKkahFHSLIIAPTRELSRQ 98
Cdd:PRK11776 17 ANLNELGYTEMTPIQAQSLPaILAG-KDVIAQAKTGSGKTAAFGLGLLQKL-----DVKRFR---VQALVLCPTRELADQ 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 99 I--ESVVLSFLEHypsdlfPIKCQLLVGTneATVRDDVSNfLRNRPQILIGTPGRVLDFLQMPAVKTSACSMVVMDEADR 176
Cdd:PRK11776 88 VakEIRRLARFIP------NIKVLTLCGG--VPMGPQIDS-LEHGAHIIVGTPGRILDHLRKGTLDLDALNTLVLDEADR 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 177 LLDMSFIKDTEKILRLLPKQRRTGLFSATMRSAGSDIFKTGLRNPVRITVNSKNQAPsSLKLNYCVVNPAEKLQLLVSIL 256
Cdd:PRK11776 159 MLDMGFQDAIDAIIRQAPARRQTLLFSATYPEGIAAISQRFQRDPVEVKVESTHDLP-AIEQRFYEVSPDERLPALQRLL 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 257 NNYKFKKCIVYFPT---CVSVSYfysfiqYLGKRNILVneveiFSLHGKLQTSARTKTLTAFTDSlSNSVLFTTDVAARG 333
Cdd:PRK11776 238 LHHQPESCVVFCNTkkeCQEVAD------ALNAQGFSA-----LALHGDLEQRDRDQVLVRFANR-SCSVLVATDVAARG 305
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 14318521 334 IDIPDVDLVIQLDPPTNTDMFMHRCGRTGRANRVGKAITFLNE 376
Cdd:PRK11776 306 LDIKALEAVINYELARDPEVHVHRIGRTGRAGSKGLALSLVAP 348
|
|
| PRK11634 |
PRK11634 |
ATP-dependent RNA helicase DeaD; Provisional |
18-393 |
1.05e-54 |
|
ATP-dependent RNA helicase DeaD; Provisional
Pssm-ID: 236941 [Multi-domain] Cd Length: 629 Bit Score: 196.22 E-value: 1.05e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 18 IRTGLDVMGFETMTPVQASTIPMLAGNKDVVVDSVTGSGKTAAFVIPVLEKVvKEEANTSKFkkahfhsLIIAPTRELSR 97
Cdd:PRK11634 17 ILEALNDLGYEKPSPIQAECIPHLLNGRDVLGMAQTGSGKTAAFSLPLLHNL-DPELKAPQI-------LVLAPTRELAV 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 98 QIESVVLSFLEHYPSdlfpIKCQLLVGTNeatvRDDVS-NFLRNRPQILIGTPGRVLDFLQMPAVKTSACSMVVMDEADR 176
Cdd:PRK11634 89 QVAEAMTDFSKHMRG----VNVVALYGGQ----RYDVQlRALRQGPQIVVGTPGRLLDHLKRGTLDLSKLSGLVLDEADE 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 177 LLDMSFIKDTEKILRLLPKQRRTGLFSATMRSAGSDIFKTGLRNPVRITVNSKNQAPSSLKLNYCVVNPAEKLQLLVSIL 256
Cdd:PRK11634 161 MLRMGFIEDVETIMAQIPEGHQTALFSATMPEAIRRITRRFMKEPQEVRIQSSVTTRPDISQSYWTVWGMRKNEALVRFL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 257 NNYKFKKCIVYFPTcvsvsyfysfiqylgkRNILVNEVEIF--------SLHGKLQTSARTKTLTAFTDSLSNsVLFTTD 328
Cdd:PRK11634 241 EAEDFDAAIIFVRT----------------KNATLEVAEALerngynsaALNGDMNQALREQTLERLKDGRLD-ILIATD 303
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 14318521 329 VAARGIDIPDVDLVIQLDPPTNTDMFMHRCGRTGRANRVGKAITFLnEGREEDF-----------IPFMQVKNVEL 393
Cdd:PRK11634 304 VAARGLDVERISLVVNYDIPMDSESYVHRIGRTGRAGRAGRALLFV-ENRERRLlrniertmkltIPEVELPNAEL 378
|
|
| DEADc_MSS116 |
cd17964 |
DEAD-box helicase domain of DEAD-box helicase Mss116; Mss116 is an RNA chaperone important for ... |
18-219 |
1.88e-53 |
|
DEAD-box helicase domain of DEAD-box helicase Mss116; Mss116 is an RNA chaperone important for mitochondrial group I and II intron splicing, translational activation, and RNA end processing. Mss116 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350722 [Multi-domain] Cd Length: 211 Bit Score: 181.63 E-value: 1.88e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 18 IRTGLDVMGFETMTPVQASTI-PMLAGNKDVVVDSVTGSGKTAAFVIPVLEKVVKeeaNTSKFKKAHFHSLIIAPTRELS 96
Cdd:cd17964 5 LLKALTRMGFETMTPVQQKTLkPILSTGDDVLARAKTGTGKTLAFLLPAIQSLLN---TKPAGRRSGVSALIISPTRELA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 97 RQIESVVLSFLEHYPsdlfPIKCQLLVGtneATVRD-DVSNFLRNRPQILIGTPGRVLDFLQMPAVK--TSACSMVVMDE 173
Cdd:cd17964 82 LQIAAEAKKLLQGLR----KLRVQSAVG---GTSRRaELNRLRRGRPDILVATPGRLIDHLENPGVAkaFTDLDYLVLDE 154
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 14318521 174 ADRLLDMSFIKDTEKILRLLPK----QRRTGLFSATMRSAGSDIFKTGLR 219
Cdd:cd17964 155 ADRLLDMGFRPDLEQILRHLPEknadPRQTLLFSATVPDEVQQIARLTLK 204
|
|
| DEADc_DDX27 |
cd17947 |
DEAD-box helicase domain of DEAD box protein 27; DDX27 (also called RHLP, deficiency of ... |
21-224 |
4.28e-50 |
|
DEAD-box helicase domain of DEAD box protein 27; DDX27 (also called RHLP, deficiency of ribosomal subunits protein 1 homolog, and probable ATP-dependent RNA helicase DDX27) is involved in the processing of 5.8S and 28S ribosomal RNAs. More specifically, the encoded protein localizes to the nucleolus, where it interacts with the PeBoW complex to ensure proper 3' end formation of 47S rRNA. DDX27 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350705 [Multi-domain] Cd Length: 196 Bit Score: 172.05 E-value: 4.28e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 21 GLDVMGFETMTPVQASTIPM-LAGnKDVVVDSVTGSGKTAAFVIPVLEKVVkeeanTSKFKKAHFHSLIIAPTRELSRQI 99
Cdd:cd17947 4 ALSSLGFTKPTPIQAAAIPLaLLG-KDICASAVTGSGKTAAFLLPILERLL-----YRPKKKAATRVLVLVPTRELAMQC 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 100 ESVVLSFLEHYPsdlfpIKCQLLVG-----TNEATvrddvsnfLRNRPQILIGTPGRVLDFLQ-MPAVKTSACSMVVMDE 173
Cdd:cd17947 78 FSVLQQLAQFTD-----ITFALAVGglslkAQEAA--------LRARPDIVIATPGRLIDHLRnSPSFDLDSIEILVLDE 144
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 14318521 174 ADRLLDMSFIKDTEKILRLLPKQRRTGLFSATMRSAGSDIFKTGLRNPVRI 224
Cdd:cd17947 145 ADRMLEEGFADELKEILRLCPRTRQTMLFSATMTDEVKDLAKLSLNKPVRV 195
|
|
| PTZ00424 |
PTZ00424 |
helicase 45; Provisional |
21-400 |
4.21e-49 |
|
helicase 45; Provisional
Pssm-ID: 185609 [Multi-domain] Cd Length: 401 Bit Score: 175.79 E-value: 4.21e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 21 GLDVMGFETMTPVQASTIPMLAGNKDVVVDSVTGSGKTAAFVIPVLEKVvkeeantsKFKKAHFHSLIIAPTRELSRQIE 100
Cdd:PTZ00424 42 GIYSYGFEKPSAIQQRGIKPILDGYDTIGQAQSGTGKTATFVIAALQLI--------DYDLNACQALILAPTRELAQQIQ 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 101 SVVLSFlehypSDLFPIKCQLLVGTNeaTVRDDVsNFLRNRPQILIGTPGRVLDFLQMPAVKTSACSMVVMDEADRLLDM 180
Cdd:PTZ00424 114 KVVLAL-----GDYLKVRCHACVGGT--VVRDDI-NKLKAGVHMVVGTPGRVYDMIDKRHLRVDDLKLFILDEADEMLSR 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 181 SFIKDTEKILRLLPKQRRTGLFSATMRSAGSDIFKTGLRNPVRITVNSKNQAPSSLKLNYCVVNPAE-KLQLLVSILNNY 259
Cdd:PTZ00424 186 GFKGQIYDVFKKLPPDVQVALFSATMPNEILELTTKFMRDPKRILVKKDELTLEGIRQFYVAVEKEEwKFDTLCDLYETL 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 260 KFKKCIVYFPTCVSVSYFYSFIQylgKRNILVNeveifSLHGKLQTSARTKTLTAFTdSLSNSVLFTTDVAARGIDIPDV 339
Cdd:PTZ00424 266 TITQAIIYCNTRRKVDYLTKKMH---ERDFTVS-----CMHGDMDQKDRDLIMREFR-SGSTRVLITTDLLARGIDVQQV 336
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 14318521 340 DLVIQLDPPTNTDMFMHRCGRTGRANRVGKAITFLNEGREEDFIPFMQVKNVELEELDLEV 400
Cdd:PTZ00424 337 SLVINYDLPASPENYIHRIGRSGRFGRKGVAINFVTPDDIEQLKEIERHYNTQIEEMPMEV 397
|
|
| PRK01297 |
PRK01297 |
ATP-dependent RNA helicase RhlB; Provisional |
12-376 |
1.08e-48 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 234938 [Multi-domain] Cd Length: 475 Bit Score: 176.64 E-value: 1.08e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 12 FSLLPWIRTGLDVMGFETMTPVQASTIPMLAGNKDVVVDSVTGSGKTAAFVIPVLEKVVKEEANTSKFKkAHFHSLIIAP 91
Cdd:PRK01297 92 FNLAPELMHAIHDLGFPYCTPIQAQVLGYTLAGHDAIGRAQTGTGKTAAFLISIINQLLQTPPPKERYM-GEPRALIIAP 170
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 92 TRELSRQIESVVLSFLEHypSDLfpiKCQLLVGTNEAtvrDDVSNFLRNR-PQILIGTPGRVLDFLQMPAVKTSACSMVV 170
Cdd:PRK01297 171 TRELVVQIAKDAAALTKY--TGL---NVMTFVGGMDF---DKQLKQLEARfCDILVATPGRLLDFNQRGEVHLDMVEVMV 242
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 171 MDEADRLLDMSFIKDTEKILRLLPK--QRRTGLFSATMRSAGSDIFKTGLRNPVRITVNSKNQAPSSLKLNYCVVNPAEK 248
Cdd:PRK01297 243 LDEADRMLDMGFIPQVRQIIRQTPRkeERQTLLFSATFTDDVMNLAKQWTTDPAIVEIEPENVASDTVEQHVYAVAGSDK 322
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 249 LQLLVSILNNYKFKKCIVYFPTCVSVSYFYSFIQYLGkrnilvneVEIFSLHGKLQTSARTKTLTAFTDSlSNSVLFTTD 328
Cdd:PRK01297 323 YKLLYNLVTQNPWERVMVFANRKDEVRRIEERLVKDG--------INAAQLSGDVPQHKRIKTLEGFREG-KIRVLVATD 393
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 14318521 329 VAARGIDIPDVDLVIQLDPPTNTDMFMHRCGRTGRANRVGKAITFLNE 376
Cdd:PRK01297 394 VAGRGIHIDGISHVINFTLPEDPDDYVHRIGRTGRAGASGVSISFAGE 441
|
|
| PRK10590 |
PRK10590 |
ATP-dependent RNA helicase RhlE; Provisional |
5-372 |
1.88e-48 |
|
ATP-dependent RNA helicase RhlE; Provisional
Pssm-ID: 236722 [Multi-domain] Cd Length: 456 Bit Score: 175.38 E-value: 1.88e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 5 LEWDNLGFSllPWIRTGLDVMGFETMTPVQASTIPMLAGNKDVVVDSVTGSGKTAAFVIPVLEKVVKEEANTSKFKKAHf 84
Cdd:PRK10590 1 MSFDSLGLS--PDILRAVAEQGYREPTPIQQQAIPAVLEGRDLMASAQTGTGKTAGFTLPLLQHLITRQPHAKGRRPVR- 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 85 hSLIIAPTRELSRQIESVVLSFlehypSDLFPIKCQLLVG---TNEATVRddvsnfLRNRPQILIGTPGRVLDFLQMPAV 161
Cdd:PRK10590 78 -ALILTPTRELAAQIGENVRDY-----SKYLNIRSLVVFGgvsINPQMMK------LRGGVDVLVATPGRLLDLEHQNAV 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 162 KTSACSMVVMDEADRLLDMSFIKDTEKILRLLPKQRRTGLFSATMrsagSDIFKT----GLRNPVRITVNSKNQAPSSLK 237
Cdd:PRK10590 146 KLDQVEILVLDEADRMLDMGFIHDIRRVLAKLPAKRQNLLFSATF----SDDIKAlaekLLHNPLEIEVARRNTASEQVT 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 238 LNYCVVNPAEKLQLLVSILNNYKFKKCIVYFPTCVSVSYfysFIQYLGKRNILVNeveifSLHGKLQTSARTKTLTAFTD 317
Cdd:PRK10590 222 QHVHFVDKKRKRELLSQMIGKGNWQQVLVFTRTKHGANH---LAEQLNKDGIRSA-----AIHGNKSQGARTRALADFKS 293
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 14318521 318 SlSNSVLFTTDVAARGIDIPDVDLVIQLDPPTNTDMFMHRCGRTGRANRVGKAIT 372
Cdd:PRK10590 294 G-DIRVLVATDIAARGLDIEELPHVVNYELPNVPEDYVHRIGRTGRAAATGEALS 347
|
|
| DEAD |
pfam00270 |
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ... |
31-206 |
6.29e-47 |
|
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.
Pssm-ID: 425570 [Multi-domain] Cd Length: 165 Bit Score: 162.41 E-value: 6.29e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 31 TPVQASTIPMLAGNKDVVVDSVTGSGKTAAFVIPVLEKVvkeeantsKFKKAHFHSLIIAPTRELSRQIESVVLSFLEHY 110
Cdd:pfam00270 1 TPIQAEAIPAILEGRDVLVQAPTGSGKTLAFLLPALEAL--------DKLDNGPQALVLAPTRELAEQIYEELKKLGKGL 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 111 PsdlfpIKCQLLVGtneATVRDDVSNFLRNrPQILIGTPGRVLDFLQmPAVKTSACSMVVMDEADRLLDMSFIKDTEKIL 190
Cdd:pfam00270 73 G-----LKVASLLG---GDSRKEQLEKLKG-PDILVGTPGRLLDLLQ-ERKLLKNLKLLVLDEAHRLLDMGFGPDLEEIL 142
|
170
....*....|....*.
gi 14318521 191 RLLPKQRRTGLFSATM 206
Cdd:pfam00270 143 RRLPKKRQILLLSATL 158
|
|
| PRK11192 |
PRK11192 |
ATP-dependent RNA helicase SrmB; Provisional |
22-373 |
2.64e-46 |
|
ATP-dependent RNA helicase SrmB; Provisional
Pssm-ID: 236877 [Multi-domain] Cd Length: 434 Bit Score: 168.97 E-value: 2.64e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 22 LDVMGFETMTPVQASTIPMLAGNKDVVVDSVTGSGKTAAFVIPVLEKVVKEEANTSKFKKAhfhsLIIAPTRELSRQIES 101
Cdd:PRK11192 16 LQDKGYTRPTAIQAEAIPPALDGRDVLGSAPTGTGKTAAFLLPALQHLLDFPRRKSGPPRI----LILTPTRELAMQVAD 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 102 VVLSFLEHYPSDLFPIKCQLLVGtNEATVrddvsnFLRNRpQILIGTPGRVLDFLQMPAVKTSACSMVVMDEADRLLDMS 181
Cdd:PRK11192 92 QARELAKHTHLDIATITGGVAYM-NHAEV------FSENQ-DIVVATPGRLLQYIKEENFDCRAVETLILDEADRMLDMG 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 182 FIKDTEKILRLLPKQRRTGLFSATMRSAGSDIF-KTGLRNPVRITVN-SKNQAPSSLKLNYCVVNPAEKLQLLVSILNNY 259
Cdd:PRK11192 164 FAQDIETIAAETRWRKQTLLFSATLEGDAVQDFaERLLNDPVEVEAEpSRRERKKIHQWYYRADDLEHKTALLCHLLKQP 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 260 KFKKCIVYFPTCVSVSyfySFIQYLGKRNIlvnevEIFSLHGKLQTSARTKTLTAFTDSLSNsVLFTTDVAARGIDIPDV 339
Cdd:PRK11192 244 EVTRSIVFVRTRERVH---ELAGWLRKAGI-----NCCYLEGEMVQAKRNEAIKRLTDGRVN-VLVATDVAARGIDIDDV 314
|
330 340 350
....*....|....*....|....*....|....
gi 14318521 340 DLVIQLDPPTNTDMFMHRCGRTGRANRVGKAITF 373
Cdd:PRK11192 315 SHVINFDMPRSADTYLHRIGRTGRAGRKGTAISL 348
|
|
| PRK04837 |
PRK04837 |
ATP-dependent RNA helicase RhlB; Provisional |
12-373 |
8.52e-46 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 235314 [Multi-domain] Cd Length: 423 Bit Score: 167.46 E-value: 8.52e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 12 FSLLPWIRTGLDVMGFETMTPVQASTIPMLAGNKDVVVDSVTGSGKTAAFVIPVLEKVVKEEANTSKfKKAHFHSLIIAP 91
Cdd:PRK04837 13 FALHPQVVEALEKKGFHNCTPIQALALPLTLAGRDVAGQAQTGTGKTMAFLTATFHYLLSHPAPEDR-KVNQPRALIMAP 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 92 TRELSRQIESVVLSFLEHYPsdlfpIKCQLLVGTNEATVRDDVsnfLRNRPQILIGTPGRVLDFLQMPAVKTSACSMVVM 171
Cdd:PRK04837 92 TRELAVQIHADAEPLAQATG-----LKLGLAYGGDGYDKQLKV---LESGVDILIGTTGRLIDYAKQNHINLGAIQVVVL 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 172 DEADRLLDMSFIKDTEKILRLLP--KQRRTGLFSATMRSAGSDIFKTGLRNPVRITVNSKNQAPSSLK--LNYcvvnPA- 246
Cdd:PRK04837 164 DEADRMFDLGFIKDIRWLFRRMPpaNQRLNMLFSATLSYRVRELAFEHMNNPEYVEVEPEQKTGHRIKeeLFY----PSn 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 247 -EKLQLLVSILNNYKFKKCIVYFPT---CVSVsyfYSFIQYLGKRNILvneveifsLHGKLQTSARTKTLTAFTDSLSNs 322
Cdd:PRK04837 240 eEKMRLLQTLIEEEWPDRAIIFANTkhrCEEI---WGHLAADGHRVGL--------LTGDVAQKKRLRILEEFTRGDLD- 307
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 14318521 323 VLFTTDVAARGIDIPDVDLVIQLDPPTNTDMFMHRCGRTGRANRVGKAITF 373
Cdd:PRK04837 308 ILVATDVAARGLHIPAVTHVFNYDLPDDCEDYVHRIGRTGRAGASGHSISL 358
|
|
| DEADc_DDX6 |
cd17940 |
DEAD-box helicase domain of DEAD box protein 6; DEAD box protein 6 (DDX6, also known as Rck or ... |
21-224 |
2.94e-45 |
|
DEAD-box helicase domain of DEAD box protein 6; DEAD box protein 6 (DDX6, also known as Rck or p54) participates in mRNA regulation mediated by miRNA-mediated silencing. It also plays a role in global and transcript-specific messenger RNA (mRNA) storage, translational repression, and decay. It is a member of the DEAD-box helicase family, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350698 [Multi-domain] Cd Length: 201 Bit Score: 159.00 E-value: 2.94e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 21 GLDVMGFETMTPVQASTIPMLAGNKDVVVDSVTGSGKTAAFVIPVLEKVvkeeantsKFKKAHFHSLIIAPTRELSRQIE 100
Cdd:cd17940 13 GIFEKGFEKPSPIQEESIPIALSGRDILARAKNGTGKTGAYLIPILEKI--------DPKKDVIQALILVPTRELALQTS 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 101 SVVLSFLEHypsdlfpIKCQLLVGTNEATVRDDVSNfLRNRPQILIGTPGRVLDFLQMPAVKTSACSMVVMDEADRLLDM 180
Cdd:cd17940 85 QVCKELGKH-------MGVKVMVTTGGTSLRDDIMR-LYQTVHVLVGTPGRILDLAKKGVADLSHCKTLVLDEADKLLSQ 156
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 14318521 181 SFIKDTEKILRLLPKQRRTGLFSATMRSAGSDIFKTGLRNPVRI 224
Cdd:cd17940 157 DFQPIIEKILNFLPKERQILLFSATFPLTVKNFMDRHMHNPYEI 200
|
|
| SF2_C_DEAD |
cd18787 |
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse ... |
236-374 |
4.64e-45 |
|
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis, and RNA degradation. They are superfamily (SF)2 helicases that, similar to SF1, do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350174 [Multi-domain] Cd Length: 131 Bit Score: 156.13 E-value: 4.64e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 236 LKLNYCVVNPAEKLQ-LLVSILNNYKFKKCIVYFPTCVSVSYFYSFIQYLGkrnilvneVEIFSLHGKLQTSARTKTLTA 314
Cdd:cd18787 1 IKQLYVVVEEEEKKLlLLLLLLEKLKPGKAIIFVNTKKRVDRLAELLEELG--------IKVAALHGDLSQEERERALKK 72
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 315 FTDSlSNSVLFTTDVAARGIDIPDVDLVIQLDPPTNTDMFMHRCGRTGRANRVGKAITFL 374
Cdd:cd18787 73 FRSG-KVRVLVATDVAARGLDIPGVDHVINYDLPRDAEDYVHRIGRTGRAGRKGTAITFV 131
|
|
| DEADc_DDX47 |
cd17954 |
DEAD-box helicase domain of DEAD box protein 47; DDX47 (also called E4-DEAD box protein) can ... |
25-224 |
7.58e-45 |
|
DEAD-box helicase domain of DEAD box protein 47; DDX47 (also called E4-DEAD box protein) can shuttle between the nucleus and the cytoplasm, and has an RNA-independent ATPase activity. DX47 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350712 [Multi-domain] Cd Length: 203 Bit Score: 158.25 E-value: 7.58e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 25 MGFETMTPVQASTIPMLAGNKDVVVDSVTGSGKTAAFVIPVLEKVVKeeantskfKKAHFHSLIIAPTRELSRQIESVVL 104
Cdd:cd17954 18 LGWKKPTKIQEEAIPVALQGRDIIGLAETGSGKTAAFALPILQALLE--------NPQRFFALVLAPTRELAQQISEQFE 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 105 SFlehypSDLFPIKCQLLVGTNEatvRDDVSNFLRNRPQILIGTPGRVLDFLQ-MPAVKTSACSMVVMDEADRLLDMSFI 183
Cdd:cd17954 90 AL-----GSSIGLKSAVLVGGMD---MMAQAIALAKKPHVIVATPGRLVDHLEnTKGFSLKSLKFLVMDEADRLLNMDFE 161
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 14318521 184 KDTEKILRLLPKQRRTGLFSATMRSAGSDIFKTGLRNPVRI 224
Cdd:cd17954 162 PEIDKILKVIPRERTTYLFSATMTTKVAKLQRASLKNPVKI 202
|
|
| PRK04537 |
PRK04537 |
ATP-dependent RNA helicase RhlB; Provisional |
12-376 |
1.34e-44 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 235307 [Multi-domain] Cd Length: 572 Bit Score: 167.05 E-value: 1.34e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 12 FSLLPWIRTGLDVMGFETMTPVQASTIPMLAGNKDVVVDSVTGSGKTAAFVIPVLEKVVKEEANTSKfKKAHFHSLIIAP 91
Cdd:PRK04537 14 FDLHPALLAGLESAGFTRCTPIQALTLPVALPGGDVAGQAQTGTGKTLAFLVAVMNRLLSRPALADR-KPEDPRALILAP 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 92 TRELSRQIESVVLSFlehyPSDLfPIKCQLLVGTNEatvRDDVSNFLRNRPQILIGTPGRVLDFL-QMPAVKTSACSMVV 170
Cdd:PRK04537 93 TRELAIQIHKDAVKF----GADL-GLRFALVYGGVD---YDKQRELLQQGVDVIIATPGRLIDYVkQHKVVSLHACEICV 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 171 MDEADRLLDMSFIKDTEKILRLLPKQ--RRTGLFSATMRSAGSDIFKTGLRNPVRITVNSKNQAPSSLKLNYCVVNPAEK 248
Cdd:PRK04537 165 LDEADRMFDLGFIKDIRFLLRRMPERgtRQTLLFSATLSHRVLELAYEHMNEPEKLVVETETITAARVRQRIYFPADEEK 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 249 LQLLVSILNNYKFKKCIVYFPTCVSVSYFYSFIQYLGKRnilvneveIFSLHGKLQTSARTKTLTAFTDSlSNSVLFTTD 328
Cdd:PRK04537 245 QTLLLGLLSRSEGARTMVFVNTKAFVERVARTLERHGYR--------VGVLSGDVPQKKRESLLNRFQKG-QLEILVATD 315
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 14318521 329 VAARGIDIPDVDLVIQLDPPTNTDMFMHRCGRTGRANRVGKAITFLNE 376
Cdd:PRK04537 316 VAARGLHIDGVKYVYNYDLPFDAEDYVHRIGRTARLGEEGDAISFACE 363
|
|
| DEADc_DDX54 |
cd17959 |
DEAD-box helicase domain of DEAD box protein 54; DDX54 interacts in a hormone-dependent manner ... |
12-224 |
3.16e-44 |
|
DEAD-box helicase domain of DEAD box protein 54; DDX54 interacts in a hormone-dependent manner with nuclear receptors, and represses their transcriptional activity. DDX54 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350717 [Multi-domain] Cd Length: 205 Bit Score: 156.31 E-value: 3.16e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 12 FSLLPWIRTGLDVMGFETMTPVQASTIPMLAGNKDVVVDSVTGSGKTAAFVIPVLEKVVKEEANTSkfkkahFHSLIIAP 91
Cdd:cd17959 6 MGLSPPLLRAIKKKGYKVPTPIQRKTIPLILDGRDVVAMARTGSGKTAAFLIPMIEKLKAHSPTVG------ARALILSP 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 92 TRELSRQIESVVLSFLEHypSDLfpiKCQLLVGTNEAtvrDDVSNFLRNRPQILIGTPGRVLDFLQMPAVKTSACSMVVM 171
Cdd:cd17959 80 TRELALQTLKVTKELGKF--TDL---RTALLVGGDSL---EEQFEALASNPDIIIATPGRLLHLLVEMNLKLSSVEYVVF 151
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 14318521 172 DEADRLLDMSFIKDTEKILRLLPKQRRTGLFSATMRSAGSDIFKTGLRNPVRI 224
Cdd:cd17959 152 DEADRLFEMGFAEQLHEILSRLPENRQTLLFSATLPKLLVEFAKAGLNEPVLI 204
|
|
| DEADc_DDX23 |
cd17945 |
DEAD-box helicase domain of DEAD box protein 23; DDX23 (also called U5 snRNP 100kD protein and ... |
25-225 |
4.71e-44 |
|
DEAD-box helicase domain of DEAD box protein 23; DDX23 (also called U5 snRNP 100kD protein and PRP28 homolog) is involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation. Diseases associated with DDX23 include distal hereditary motor neuropathy, type II. DDX23 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350703 [Multi-domain] Cd Length: 220 Bit Score: 156.33 E-value: 4.71e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 25 MGFETMTPVQASTIPMLAGNKDVVVDSVTGSGKTAAFVIPVLEKVVKEEANTSKFKKAHFHSLIIAPTRELSRQIESVVL 104
Cdd:cd17945 8 LGYKEPTPIQRQAIPIGLQNRDIIGIAETGSGKTAAFLIPLLVYISRLPPLDEETKDDGPYALILAPTRELAQQIEEETQ 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 105 SFLEHYPsdlfpIKCQLLVGTNEatvRDDVSNFLRNRPQILIGTPGRVLDFLQMPAVKTSACSMVVMDEADRLLDMSFIK 184
Cdd:cd17945 88 KFAKPLG-----IRVVSIVGGHS---IEEQAFSLRNGCEILIATPGRLLDCLERRLLVLNQCTYVVLDEADRMIDMGFEP 159
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 14318521 185 DTEKILRLLP--------------------KQRRTGLFSATMRSAGSDIFKTGLRNPVRIT 225
Cdd:cd17945 160 QVTKILDAMPvsnkkpdteeaeklaasgkhRYRQTMMFTATMPPAVEKIAKGYLRRPVVVT 220
|
|
| DEADc_DDX52 |
cd17957 |
DEAD-box helicase domain of DEAD box protein 52; DDX52 (also called ROK1 and HUSSY19) is ... |
26-226 |
1.48e-43 |
|
DEAD-box helicase domain of DEAD box protein 52; DDX52 (also called ROK1 and HUSSY19) is ubiquitously expressed in testis, endometrium, and other tissues in humans. DDX52 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350715 [Multi-domain] Cd Length: 198 Bit Score: 154.28 E-value: 1.48e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 26 GFETMTPVQASTIPMLAGNKDVVVDSVTGSGKTAAFVIPVLEKVVKeeantsKFKKAHFHSLIIAPTRELSRQIESVVLS 105
Cdd:cd17957 9 GYREPTPIQMQAIPILLHGRDLLACAPTGSGKTLAFLIPILQKLGK------PRKKKGLRALILAPTRELASQIYRELLK 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 106 FLEHYPsdlfpIKCQLLVGTNEATVRDDVSnfLRNRPQILIGTPGRVLDFLQMPAVKTSACSMVVMDEADRLLDMSFIKD 185
Cdd:cd17957 83 LSKGTG-----LRIVLLSKSLEAKAKDGPK--SITKYDILVSTPLRLVFLLKQGPIDLSSVEYLVLDEADKLFEPGFREQ 155
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 14318521 186 TEKILRLLP-KQRRTGLFSATMRSAGSDIFKTGLRNPVRITV 226
Cdd:cd17957 156 TDEILAACTnPNLQRSLFSATIPSEVEELARSVMKDPIRIIV 197
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
22-226 |
2.98e-41 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 148.41 E-value: 2.98e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 22 LDVMGFETMTPVQASTIP-MLAGNKDVVVDSVTGSGKTAAFVIPVLEKVvkeeantskFKKAHFHSLIIAPTRELSRQIE 100
Cdd:smart00487 1 IEKFGFEPLRPYQKEAIEaLLSGLRDVILAAPTGSGKTLAALLPALEAL---------KRGKGGRVLVLVPTRELAEQWA 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 101 SVVLSFLEHypsdlFPIKCQLLVGTNeaTVRDDVSNFLRNRPQILIGTPGRVLDFLQMPAVKTSACSMVVMDEADRLLDM 180
Cdd:smart00487 72 EELKKLGPS-----LGLKVVGLYGGD--SKREQLRKLESGKTDILVTTPGRLLDLLENDKLSLSNVDLVILDEAHRLLDG 144
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 14318521 181 SFIKDTEKILRLLPKQRRTGLFSATMRSAGSDIFKTGLRNPVRITV 226
Cdd:smart00487 145 GFGDQLEKLLKLLPKNVQLLLLSATPPEEIENLLELFLNDPVFIDV 190
|
|
| DEADc_DDX20 |
cd17943 |
DEAD-box helicase domain of DEAD box protein 20; DDX20 (also called DEAD Box Protein DP 103, ... |
21-224 |
3.56e-40 |
|
DEAD-box helicase domain of DEAD box protein 20; DDX20 (also called DEAD Box Protein DP 103, Component Of Gems 3, Gemin-3, and SMN-Interacting Protein) interacts directly with SMN (survival of motor neurons), the spinal muscular atrophy gene product, and may play a catalytic role in the function of the SMN complex on ribonucleoproteins. Diseases associated with DDX20 include spinal muscular atrophy and muscular atrophy. DDX20 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350701 [Multi-domain] Cd Length: 192 Bit Score: 145.10 E-value: 3.56e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 21 GLDVMGFETMTPVQASTIPM-LAGnKDVVVDSVTGSGKTAAFVIPVLEKVVKEeantskfkKAHFHSLIIAPTRELSRQI 99
Cdd:cd17943 4 GLKAAGFQRPSPIQLAAIPLgLAG-HDLIVQAKSGTGKTLVFVVIALESLDLE--------RRHPQVLILAPTREIAVQI 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 100 ESVVLSFLEHYPSdlfpIKCQLLVGTneATVRDDVSNFlrNRPQILIGTPGRVLDFLQMPAVKTSACSMVVMDEADRLLD 179
Cdd:cd17943 75 HDVFKKIGKKLEG----LKCEVFIGG--TPVKEDKKKL--KGCHIAVGTPGRIKQLIELGALNVSHVRLFVLDEADKLME 146
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 14318521 180 MSFIKDTEKILRLLPKQRRTGLFSATMRSAGSDIFKTGLRNPVRI 224
Cdd:cd17943 147 GSFQKDVNWIFSSLPKNKQVIAFSATYPKNLDNLLARYMRKPVLV 191
|
|
| DEADc_DDX49 |
cd17955 |
DEAD-box helicase domain of DEAD box protein 49; DDX49 (also called Dbp8) is a member of the ... |
8-206 |
1.21e-39 |
|
DEAD-box helicase domain of DEAD box protein 49; DDX49 (also called Dbp8) is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350713 [Multi-domain] Cd Length: 204 Bit Score: 143.90 E-value: 1.21e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 8 DNLGFSllPWIRTGLDVMGFETMTPVQASTIP-MLAGnKDVVVDSVTGSGKTAAFVIPVLEKVVKEEAntskfkkAHFhS 86
Cdd:cd17955 2 EDLGLS--SWLVKQCASLGIKEPTPIQKLCIPeILAG-RDVIGGAKTGSGKTAAFALPILQRLSEDPY-------GIF-A 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 87 LIIAPTRELSRQIESVVLSFlehypSDLFPIKCQLLVGTneatvRDDV--SNFLRNRPQILIGTPGRVLDFLQMPAVKTS 164
Cdd:cd17955 71 LVLTPTRELAYQIAEQFRAL-----GAPLGLRCCVIVGG-----MDMVkqALELSKRPHIVVATPGRLADHLRSSDDTTK 140
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 14318521 165 ACSMV---VMDEADRLLDMSFIKDTEKILRLLPKQRRTGLFSATM 206
Cdd:cd17955 141 VLSRVkflVLDEADRLLTGSFEDDLATILSALPPKRQTLLFSATL 185
|
|
| DEADc_DDX10 |
cd17941 |
DEAD-box helicase domain of DEAD box protein 10; Fusion of the DDX10 gene and the nucleoporin ... |
21-227 |
1.47e-39 |
|
DEAD-box helicase domain of DEAD box protein 10; Fusion of the DDX10 gene and the nucleoporin gene, NUP98, by inversion 11 (p15q22) chromosome translocation is found in the patients with de novo or therapy-related myeloid malignancies. Diseases associated with DDX10 (also known as DDX10-NUP98 Fusion Protein Type 2) include myelodysplastic syndrome and leukemia, acute myeloid. DDX10 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350699 [Multi-domain] Cd Length: 198 Bit Score: 143.58 E-value: 1.47e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 21 GLDVMGFETMTPVQASTIPM-LAGnKDVVVDSVTGSGKTAAFVIPVLEKVVKEEANTSKFKKAhfhsLIIAPTRELSRQI 99
Cdd:cd17941 4 GLKEAGFIKMTEIQRDSIPHaLQG-RDILGAAKTGSGKTLAFLVPLLEKLYRERWTPEDGLGA----LIISPTRELAMQI 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 100 ESVvLSFLEHYPSdlfpIKCQLLVGTNEATV-RDDVsnflrNRPQILIGTPGRVLDFL-QMPAVKTSACSMVVMDEADRL 177
Cdd:cd17941 79 FEV-LRKVGKYHS----FSAGLIIGGKDVKEeKERI-----NRMNILVCTPGRLLQHMdETPGFDTSNLQMLVLDEADRI 148
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 14318521 178 LDMSFIKDTEKILRLLPKQRRTGLFSATMRSAGSDIFKTGLRNPVRITVN 227
Cdd:cd17941 149 LDMGFKETLDAIVENLPKSRQTLLFSATQTKSVKDLARLSLKNPEYISVH 198
|
|
| DEADc_DDX3_DDX4 |
cd17967 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX3 and DDX4; This subfamily includes ... |
14-205 |
5.82e-38 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX3 and DDX4; This subfamily includes Drosophila melanogaster Vasa, which is essential for development. DEAD box protein 3 (DDX3) has been reported to display a high level of RNA-independent ATPase activity stimulated by both RNA and DNA. DEAD box protein 4 (DDX4, also known as VASA homolog) is an ATP-dependent RNA helicase required during spermatogenesis and is essential for the germline integrity. DDX3 and DDX4 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350725 [Multi-domain] Cd Length: 221 Bit Score: 139.93 E-value: 5.82e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 14 LLPWIRTGLDVMGFETMTPVQASTIPMLAGNKDVVVDSVTGSGKTAAFVIPVLEKVVKEEANTSKF--KKAHFHSLIIAP 91
Cdd:cd17967 7 LRELLLENIKRAGYTKPTPVQKYAIPIILAGRDLMACAQTGSGKTAAFLLPIISKLLEDGPPSVGRgrRKAYPSALILAP 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 92 TRELSRQIESVVLSFLehYPSdlfPIKCQLLVGTneATVRDDVSNFLRNrPQILIGTPGRVLDFLQMPAVKTSACSMVVM 171
Cdd:cd17967 87 TRELAIQIYEEARKFS--YRS---GVRSVVVYGG--ADVVHQQLQLLRG-CDILVATPGRLVDFIERGRISLSSIKFLVL 158
|
170 180 190
....*....|....*....|....*....|....*...
gi 14318521 172 DEADRLLDMSFIKDTEKILR---LLPK-QRRTGLFSAT 205
Cdd:cd17967 159 DEADRMLDMGFEPQIRKIVEhpdMPPKgERQTLMFSAT 196
|
|
| DEADc_DDX18 |
cd17942 |
DEAD-box helicase domain of DEAD box protein 18; This DDX18 gene encodes a DEAD box protein ... |
18-221 |
6.40e-38 |
|
DEAD-box helicase domain of DEAD box protein 18; This DDX18 gene encodes a DEAD box protein and is activated by Myc protein. DDX18 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350700 [Multi-domain] Cd Length: 198 Bit Score: 139.03 E-value: 6.40e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 18 IRTGLDVMGFETMTPVQASTIPMLAGNKDVVVDSVTGSGKTAAFVIPVLEKVVKeeantSKFK-KAHFHSLIIAPTRELS 96
Cdd:cd17942 1 TLKAIEEMGFTKMTEIQAKSIPPLLEGRDVLGAAKTGSGKTLAFLIPAIELLYK-----LKFKpRNGTGVIIISPTRELA 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 97 RQIESVVLSFLEHYpSDLFPIkcqLLVGTNeatvRDDVSNFLRNRPQILIGTPGRVLDFLQMPA---VKTSACsmVVMDE 173
Cdd:cd17942 76 LQIYGVAKELLKYH-SQTFGI---VIGGAN----RKAEAEKLGKGVNILVATPGRLLDHLQNTKgflYKNLQC--LIIDE 145
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 14318521 174 ADRLLDMSFIKDTEKILRLLPKQRRTGLFSATMRSAGSDIFKTGLRNP 221
Cdd:cd17942 146 ADRILEIGFEEEMRQIIKLLPKRRQTMLFSATQTRKVEDLARISLKKK 193
|
|
| DEADc_DDX56 |
cd17961 |
DEAD-box helicase domain of DEAD box protein 56; DDX56 is a helicase required for assembly of ... |
14-226 |
1.39e-37 |
|
DEAD-box helicase domain of DEAD box protein 56; DDX56 is a helicase required for assembly of infectious West Nile virus particles. New research suggests that DDX56 relocalizes to the site of virus assembly during WNV infection and that its interaction with WNV capsid in the cytoplasm may occur transiently during virion morphogenesis. DDX56 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350719 [Multi-domain] Cd Length: 206 Bit Score: 138.49 E-value: 1.39e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 14 LLPWIRTGLDVMGFETMTPVQASTIPMLAGNKDVVVDSVTGSGKTAAFVIPVLEKVVKEEANTSkfKKAHFHSLIIAPTR 93
Cdd:cd17961 1 LDPRLLKAIAKLGWEKPTLIQSKAIPLALEGKDILARARTGSGKTAAYALPIIQKILKAKAESG--EEQGTRALILVPTR 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 94 ELSRQIESVVLSFLEHYPSDlfpIKCQLLVGTNEATVRddvSNFLRNRPQILIGTPGRVLDFLQ-MPAVKTSACSMVVMD 172
Cdd:cd17961 79 ELAQQVSKVLEQLTAYCRKD---VRVVNLSASSSDSVQ---RALLAEKPDIVVSTPARLLSHLEsGSLLLLSTLKYLVID 152
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 14318521 173 EADRLLDMSFIKDTEKILRLLPKQRRTGLFSATMRSAGSDIFKTGLRNPVRITV 226
Cdd:cd17961 153 EADLVLSYGYEEDLKSLLSYLPKNYQTFLMSATLSEDVEALKKLVLHNPAILKL 206
|
|
| DEADc_DDX31 |
cd17949 |
DEAD-box helicase domain of DEAD box protein 31; DDX31 (also called helicain or G2 helicase) ... |
24-225 |
1.25e-36 |
|
DEAD-box helicase domain of DEAD box protein 31; DDX31 (also called helicain or G2 helicase) plays a role in ribosome biogenesis and TP53/p53 regulation through its interaction with NPM1. DDX31 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350707 [Multi-domain] Cd Length: 214 Bit Score: 135.79 E-value: 1.25e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 24 VMGFETMTPVQASTIPMLAGNKDVVVDSVTGSGKTAAFVIPVLEKVVKeeaNTSKFKKAH-FHSLIIAPTRELSRQIESV 102
Cdd:cd17949 8 KMGIEKPTAIQKLAIPVLLQGRDVLVRSQTGSGKTLAYLLPIIQRLLS---LEPRVDRSDgTLALVLVPTRELALQIYEV 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 103 VLSFLEHYPsdlFPIKCQLLVGTN----EATVRDDVSnflrnrpqILIGTPGRVLDFLQMP-AVKTSACSMVVMDEADRL 177
Cdd:cd17949 85 LEKLLKPFH---WIVPGYLIGGEKrkseKARLRKGVN--------ILIATPGRLLDHLKNTqSFDVSNLRWLVLDEADRL 153
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 14318521 178 LDMSFIKDTEKILRLL-------------PKQRRTGLFSATMRSAGSDIFKTGLRNPVRIT 225
Cdd:cd17949 154 LDMGFEKDITKILELLddkrskaggekskPSRRQTVLVSATLTDGVKRLAGLSLKDPVYID 214
|
|
| DEADc_EIF4A |
cd17939 |
DEAD-box helicase domain of eukaryotic initiation factor 4A; The eukaryotic initiation ... |
26-224 |
2.71e-36 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A; The eukaryotic initiation factor-4A (eIF4A) family consists of 3 proteins EIF4A1, EIF4A2, and EIF4A3. These factors are required for the binding of mRNA to 40S ribosomal subunits. In addition these proteins are helicases that function to unwind double-stranded RNA. EIF4A proteins are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350697 [Multi-domain] Cd Length: 199 Bit Score: 134.37 E-value: 2.71e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 26 GFETMTPVQASTI-PMLAGnKDVVVDSVTGSGKTAAFVIPVLEKVvkeeANTSKFKKAhfhsLIIAPTRELSRQIESVVL 104
Cdd:cd17939 16 GFEKPSAIQQRAIvPIIKG-RDVIAQAQSGTGKTATFSIGALQRI----DTTVRETQA----LVLAPTRELAQQIQKVVK 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 105 SFLEHypsdlFPIKCQLLVG-TNeatVRDDVSNfLRNRPQILIGTPGRVLDFLQMPAVKTSACSMVVMDEADRLLDMSFI 183
Cdd:cd17939 87 ALGDY-----MGVKVHACIGgTS---VREDRRK-LQYGPHIVVGTPGRVFDMLQRRSLRTDKIKMFVLDEADEMLSRGFK 157
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 14318521 184 KDTEKILRLLPKQRRTGLFSATMRSAGSDIFKTGLRNPVRI 224
Cdd:cd17939 158 DQIYDIFQFLPPETQVVLFSATMPHEVLEVTKKFMRDPVRI 198
|
|
| PTZ00110 |
PTZ00110 |
helicase; Provisional |
26-374 |
2.75e-36 |
|
helicase; Provisional
Pssm-ID: 240273 [Multi-domain] Cd Length: 545 Bit Score: 142.99 E-value: 2.75e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 26 GFETMTPVQASTIPMLAGNKDVVVDSVTGSGKTAAFVIPVlekVVKEEANTSKFKKAHFHSLIIAPTRELSRQIESVVLS 105
Cdd:PTZ00110 149 GFTEPTPIQVQGWPIALSGRDMIGIAETGSGKTLAFLLPA---IVHINAQPLLRYGDGPIVLVLAPTRELAEQIREQCNK 225
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 106 FlehypSDLFPIKCQLLVGtneATVRDDVSNFLRNRPQILIGTPGRVLDFLQMPAVKTSACSMVVMDEADRLLDMSFIKD 185
Cdd:PTZ00110 226 F-----GASSKIRNTVAYG---GVPKRGQIYALRRGVEILIACPGRLIDFLESNVTNLRRVTYLVLDEADRMLDMGFEPQ 297
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 186 TEKILRLLPKQRRTGLFSAT----MRSAGSDIFKtglRNPVRITVNSKN-QAPSSLKLNYCVVNPAEKLQLLVSILNNYK 260
Cdd:PTZ00110 298 IRKIVSQIRPDRQTLMWSATwpkeVQSLARDLCK---EEPVHVNVGSLDlTACHNIKQEVFVVEEHEKRGKLKMLLQRIM 374
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 261 FK--KCIVYFPTcvsvsyfysfiqylgKRN--ILVNEVEI-----FSLHGKLQTSARTKTLTAFTDSlSNSVLFTTDVAA 331
Cdd:PTZ00110 375 RDgdKILIFVET---------------KKGadFLTKELRLdgwpaLCIHGDKKQEERTWVLNEFKTG-KSPIMIATDVAS 438
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 14318521 332 RGIDIPDVDLVIQLDPPTNTDMFMHRCGRTGRANRVGKAITFL 374
Cdd:PTZ00110 439 RGLDVKDVKYVINFDFPNQIEDYVHRIGRTGRAGAKGASYTFL 481
|
|
| PLN00206 |
PLN00206 |
DEAD-box ATP-dependent RNA helicase; Provisional |
10-388 |
2.42e-34 |
|
DEAD-box ATP-dependent RNA helicase; Provisional
Pssm-ID: 215103 [Multi-domain] Cd Length: 518 Bit Score: 136.84 E-value: 2.42e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 10 LGFS---LLPWIRTGLDVMGFETMTPVQASTIPMLAGNKDVVVDSVTGSGKTAAFVIPVLEKVVK-EEANTSKFKKAhfH 85
Cdd:PLN00206 121 LSFSscgLPPKLLLNLETAGYEFPTPIQMQAIPAALSGRSLLVSADTGSGKTASFLVPIISRCCTiRSGHPSEQRNP--L 198
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 86 SLIIAPTRELSRQIEsvvlsflEHypSDLF----PIKCQLLVGTneatvrDDVSNFL---RNRPQILIGTPGRVLDFLQM 158
Cdd:PLN00206 199 AMVLTPTRELCVQVE-------DQ--AKVLgkglPFKTALVVGG------DAMPQQLyriQQGVELIVGTPGRLIDLLSK 263
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 159 PAVKTSACSMVVMDEADRLLDMSFIKDTEKILRLLPkQRRTGLFSATMRSAGSDIFKTGLRNPVRITVNSKNQAPSSLKL 238
Cdd:PLN00206 264 HDIELDNVSVLVLDEVDCMLERGFRDQVMQIFQALS-QPQVLLFSATVSPEVEKFASSLAKDIILISIGNPNRPNKAVKQ 342
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 239 NYCVVNPAEKLQLLVSILnnykfkKCIVYF--PTCVSVSyfySFI--QYLGKRNILVNEVEIFSLHGKLQTSARTKTLTA 314
Cdd:PLN00206 343 LAIWVETKQKKQKLFDIL------KSKQHFkpPAVVFVS---SRLgaDLLANAITVVTGLKALSIHGEKSMKERREVMKS 413
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 14318521 315 FTDSlSNSVLFTTDVAARGIDIPDVDLVIQLDPPTNTDMFMHRCGRTGRANRVGKAITFLNEGREEDFIPFMQV 388
Cdd:PLN00206 414 FLVG-EVPVIVATGVLGRGVDLLRVRQVIIFDMPNTIKEYIHQIGRASRMGEKGTAIVFVNEEDRNLFPELVAL 486
|
|
| DEADc_EIF4AII_EIF4AI_DDX2 |
cd18046 |
DEAD-box helicase domain of eukaryotic initiation factor 4A-I and 4-II; Eukaryotic initiation ... |
26-224 |
3.50e-34 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A-I and 4-II; Eukaryotic initiation factor 4A-I (DDX2A) and eukaryotic initiation factor 4A-II (DDX2B) are involved in cap recognition and are required for mRNA binding to ribosome. They are DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350804 [Multi-domain] Cd Length: 201 Bit Score: 128.72 E-value: 3.50e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 26 GFETMTPVQASTI-PMLAGnKDVVVDSVTGSGKTAAFVIPVLEKVVKEEANTskfkkahfHSLIIAPTRELSRQIESVVL 104
Cdd:cd18046 18 GFEKPSAIQQRAImPCIKG-YDVIAQAQSGTGKTATFSISILQQIDTSLKAT--------QALVLAPTRELAQQIQKVVM 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 105 SFlehypSDLFPIKCQLLVG-TNeatVRDDVsNFLRNRPQILIGTPGRVLDFLQMPAVKTSACSMVVMDEADRLLDMSFI 183
Cdd:cd18046 89 AL-----GDYMGIKCHACIGgTS---VRDDA-QKLQAGPHIVVGTPGRVFDMINRRYLRTDYIKMFVLDEADEMLSRGFK 159
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 14318521 184 KDTEKILRLLPKQRRTGLFSATMRSAGSDIFKTGLRNPVRI 224
Cdd:cd18046 160 DQIYDIFQKLPPDTQVVLLSATMPNDVLEVTTKFMRDPIRI 200
|
|
| DEADc_DDX19_DDX25 |
cd17963 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX19 and DDX25; DDX19 (also called ... |
21-225 |
1.58e-33 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX19 and DDX25; DDX19 (also called DEAD box RNA helicase DEAD5) and DDX25 (also called gonadotropin-regulated testicular RNA helicase (GRTH)) are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350721 [Multi-domain] Cd Length: 196 Bit Score: 126.54 E-value: 1.58e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 21 GLDVMGFETMTPVQASTIPMLAGN--KDVVVDSVTGSGKTAAFVIPVLEKVVkeeaNTSKFKKAhfhsLIIAPTRELSRQ 98
Cdd:cd17963 8 GLYAMGFNKPSKIQETALPLILSDppENLIAQSQSGTGKTAAFVLAMLSRVD----PTLKSPQA----LCLAPTRELARQ 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 99 IESVVLSfLEHYPSdlfpIKCQLLVGTNEATVRDDVSNflrnrpQILIGTPGRVLDFLQMPAVKTSACSMVVMDEADRLL 178
Cdd:cd17963 80 IGEVVEK-MGKFTG----VKVALAVPGNDVPRGKKITA------QIVIGTPGTVLDWLKKRQLDLKKIKILVLDEADVML 148
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 14318521 179 DM-SFIKDTEKILRLLPKQRRTGLFSATMRSAGSDIFKTGLRNPVRIT 225
Cdd:cd17963 149 DTqGHGDQSIRIKRMLPRNCQILLFSATFPDSVRKFAEKIAPNANTIK 196
|
|
| DEADc_DDX1 |
cd17938 |
DEAD-box helicase domain of DEAD box protein 1; DEAD box protein 1 (DDX1) acts as an ... |
12-208 |
3.83e-33 |
|
DEAD-box helicase domain of DEAD box protein 1; DEAD box protein 1 (DDX1) acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. It possesses 5' single-stranded RNA overhang nuclease activity as well as ATPase activity on various RNA, but not DNA polynucleotides. DDX1 may play a role in RNA clearance at DNA double-strand breaks (DSBs), thereby facilitating the template-guided repair of transcriptionally active regions of the genome. It may also be involved in 3'-end cleavage and polyadenylation of pre-mRNAs. DDX1 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350696 [Multi-domain] Cd Length: 204 Bit Score: 125.90 E-value: 3.83e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 12 FSLLPWIRTGLDVMGFETMTPVQASTIPMLAGNKDVVVDSVTGSGKTAAFVIPVLEKVVkeeantskfkkahfhSLIIAP 91
Cdd:cd17938 4 LGVMPELIKAVEELDWLLPTDIQAEAIPLILGGGDVLMAAETGSGKTGAFCLPVLQIVV---------------ALILEP 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 92 TRELSRQIESVVLSFLEHY--PSdlfpIKCQLLVG---TNEATVRddvsnfLRNRPQILIGTPGRVLDFLQMPAVKTSAC 166
Cdd:cd17938 69 SRELAEQTYNCIENFKKYLdnPK----LRVALLIGgvkAREQLKR------LESGVDIVVGTPGRLEDLIKTGKLDLSSV 138
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 14318521 167 SMVVMDEADRLLDMSFIKDTEKILRLLPKQRRTG------LFSATMRS 208
Cdd:cd17938 139 RFFVLDEADRLLSQGNLETINRIYNRIPKITSDGkrlqviVCSATLHS 186
|
|
| DEADc_DDX42 |
cd17952 |
DEAD-box helicase domain of DEAD box protein 42; DDX42 (also called Splicing Factor ... |
26-225 |
5.53e-33 |
|
DEAD-box helicase domain of DEAD box protein 42; DDX42 (also called Splicing Factor 3B-Associated 125 kDa Protein, RHELP, or RNAHP) is an NTPase with a preference for ATP, the hydrolysis of which is enhanced by various RNA substrates. It acts as a non-processive RNA helicase with protein displacement and RNA annealing activities. DDX42 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350710 [Multi-domain] Cd Length: 197 Bit Score: 125.22 E-value: 5.53e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 26 GFETMTPVQASTIPMLAGNKDVVVDSVTGSGKTAAFVIPVLEKVVKEEANTskfKKAHFHSLIIAPTRELSRQIESVVLS 105
Cdd:cd17952 9 EYEQPTPIQAQALPVALSGRDMIGIAKTGSGKTAAFIWPMLVHIMDQRELE---KGEGPIAVIVAPTRELAQQIYLEAKK 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 106 FlehypSDLFPIKCQLLVGtneATVRDDVSNFLRNRPQILIGTPGRVLDFLQMPAVKTSACSMVVMDEADRLLDMSFIKD 185
Cdd:cd17952 86 F-----GKAYNLRVVAVYG---GGSKWEQAKALQEGAEIVVATPGRLIDMVKKKATNLQRVTYLVLDEADRMFDMGFEYQ 157
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 14318521 186 TEKILRLLPKQRRTGLFSATMRSAGSDIFKTGLRNPVRIT 225
Cdd:cd17952 158 VRSIVGHVRPDRQTLLFSATFKKKIEQLARDILSDPIRVV 197
|
|
| DEADc_DDX4 |
cd18052 |
DEAD-box helicase domain of DEAD box protein 4; DEAD box protein 4 (DDX4, also known as VASA ... |
14-205 |
3.85e-31 |
|
DEAD-box helicase domain of DEAD box protein 4; DEAD box protein 4 (DDX4, also known as VASA homolog) is an ATP-dependent RNA helicase required during spermatogenesis and is essential for the germline integrity. DEAD-box helicases are a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350810 [Multi-domain] Cd Length: 264 Bit Score: 122.00 E-value: 3.85e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 14 LLPWIRTGLDVMGFETMTPVQASTIPMLAGNKDVVVDSVTGSGKTAAFVIPVLEKVVKEEANTSKFKK-AHFHSLIIAPT 92
Cdd:cd18052 50 LCETLLKNIRKAGYEKPTPVQKYAIPIILAGRDLMACAQTGSGKTAAFLLPVLTGMMKEGLTASSFSEvQEPQALIVAPT 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 93 RELSRQIESVVLSFleHYPSDLFPIKC-----------QLLVGTNeatvrddvsnflrnrpqILIGTPGRVLDFLQMPAV 161
Cdd:cd18052 130 RELANQIFLEARKF--SYGTCIRPVVVyggvsvghqirQIEKGCH-----------------ILVATPGRLLDFIGRGKI 190
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 14318521 162 KTSACSMVVMDEADRLLDMSFIKDTEKILRLL---PKQRR-TGLFSAT 205
Cdd:cd18052 191 SLSKLKYLILDEADRMLDMGFGPEIRKLVSEPgmpSKEDRqTLMFSAT 238
|
|
| DEADc_DDX41 |
cd17951 |
DEAD-box helicase domain of DEAD box protein 41; DDX41 (also called ABS and MPLPF) interacts ... |
18-227 |
1.65e-30 |
|
DEAD-box helicase domain of DEAD box protein 41; DDX41 (also called ABS and MPLPF) interacts with several spliceosomal proteins and may recognize the bacterial second messengers cyclic di-GMP and cyclic di-AMP, resulting in the induction of genes involved in the innate immune response. Diseases associated with DDX41 include "myeloproliferative/lymphoproliferative neoplasms, familial" and "Ddx41-related susceptibility to familial myeloproliferative/lymphoproliferative neoplasms". DDX41 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350709 [Multi-domain] Cd Length: 206 Bit Score: 118.60 E-value: 1.65e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 18 IRTGLDVMGFETMTPVQASTIPMLAGNKDVVVDSVTGSGKTAAFVIPVLEKVVKEEANTSKFKKAHFHSLIIAPTRELSR 97
Cdd:cd17951 1 ILKGLKKKGIKKPTPIQMQGLPTILSGRDMIGIAFTGSGKTLVFTLPLIMFALEQEKKLPFIKGEGPYGLIVCPSRELAR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 98 QIESVVLSFLEHYPSDLFP-IKCQLLVGTNEATvrdDVSNFLRNRPQILIGTPGRVLDFLQMPAVKTSACSMVVMDEADR 176
Cdd:cd17951 81 QTHEVIEYYCKALQEGGYPqLRCLLCIGGMSVK---EQLEVIRKGVHIVVATPGRLMDMLNKKKINLDICRYLCLDEADR 157
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 14318521 177 LLDMSFIKDTEKILRLLPKQRRTGLFSATMRSAGSDIFKTGLRNPVriTVN 227
Cdd:cd17951 158 MIDMGFEEDIRTIFSYFKGQRQTLLFSATMPKKIQNFAKSALVKPV--TVN 206
|
|
| DEADc_DDX59 |
cd17962 |
DEAD-box helicase domain of DEAD box protein 59; DDX59 plays an important role in lung cancer ... |
22-225 |
2.58e-30 |
|
DEAD-box helicase domain of DEAD box protein 59; DDX59 plays an important role in lung cancer development by promoting DNA replication. DDX59 knockdown mice showed reduced cell proliferation, anchorage-independent cell growth, and reduction of tumor formation. Recent work shows that EGFR and Ras regulate DDX59 during lung cancer development. Diseases associated with DDX59 (also called zinc finger HIT domain-containing protein 5) include orofaciodigital syndrome V and orofaciodigital syndrome. DDX59 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350720 [Multi-domain] Cd Length: 193 Bit Score: 117.65 E-value: 2.58e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 22 LDVMGFETMTPVQASTIPMLAGNKDVVVDSVTGSGKTAAFVIPVLEKVVKEEANTSkfkkahfhSLIIAPTRELSRQIES 101
Cdd:cd17962 5 LKKAGYEVPTPIQMQMIPVGLLGRDILASADTGSGKTAAFLLPVIIRCLTEHRNPS--------ALILTPTRELAVQIED 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 102 VVLSFLEHYPsdlfPIKCQLLVGTNEATVRddvSNFLRNRPQILIGTPGRVLDFLQMPAVKTSACSMVVMDEADRLLDMS 181
Cdd:cd17962 77 QAKELMKGLP----PMKTALLVGGLPLPPQ---LYRLQQGVKVIIATPGRLLDILKQSSVELDNIKIVVVDEADTMLKMG 149
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 14318521 182 FIKDTEKILRLLPKQRRTGLFSATMRSAGSDIFKTGLRNPVRIT 225
Cdd:cd17962 150 FQQQVLDILENISHDHQTILVSATIPRGIEQLAGQLLQNPVRIT 193
|
|
| DEADc_DDX24 |
cd17946 |
DEAD-box helicase domain of DEAD box protein 24; The human DDX24 gene encodes a DEAD box ... |
18-257 |
1.88e-29 |
|
DEAD-box helicase domain of DEAD box protein 24; The human DDX24 gene encodes a DEAD box protein, which shows little similarity to any of the other known human DEAD box proteins, but shows a high similarity to mouse Ddx24 at the amino acid level. MDM2 mediates nonproteolytic polyubiquitylation of the DEAD-Box RNA helicase DDX24. DDX24 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP- binding region.
Pssm-ID: 350704 [Multi-domain] Cd Length: 235 Bit Score: 116.57 E-value: 1.88e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 18 IRTGLDVMGFETMTPVQASTIPM-LAGNKDVVVDSVTGSGKTAAFVIPVLEKVVKE-EANTSKFKKAHFHSLIIAPTREL 95
Cdd:cd17946 1 ILRALADLGFSEPTPIQALALPAaIRDGKDVIGAAETGSGKTLAFGIPILERLLSQkSSNGVGGKQKPLRALILTPTREL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 96 SRQIEsvvlsflEH------YPSdlfpIKCQLLVGtNEATVRDDvsNFLRNRPQILIGTPGRVLDFLQ-----MPAVKTS 164
Cdd:cd17946 81 AVQVK-------DHlkaiakYTN----IKIASIVG-GLAVQKQE--RLLKKRPEIVVATPGRLWELIQegnehLANLKSL 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 165 ACsmVVMDEADRLLDMSFIKDTEKILRLLP-------KQRRTGLFSATmrsagsdiFKTGLRNPVRITVNSKNQApsslk 237
Cdd:cd17946 147 RF--LVLDEADRMLEKGHFAELEKILELLNkdragkkRKRQTFVFSAT--------LTLDHQLPLKLNSKKKKKK----- 211
|
250 260
....*....|....*....|
gi 14318521 238 lnycvVNPAEKLQLLVSILN 257
Cdd:cd17946 212 -----KEKKQKLELLIEKVG 226
|
|
| DEADc_DDX46 |
cd17953 |
DEAD-box helicase domain of DEAD box protein 46; DDX46 (also called Prp5-like DEAD-box protein) ... |
5-225 |
1.06e-28 |
|
DEAD-box helicase domain of DEAD box protein 46; DDX46 (also called Prp5-like DEAD-box protein) is a component of the 17S U2 snRNP complex. It plays an important role in pre-mRNA splicing and has a role in antiviral innate immunity. DDX46 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350711 [Multi-domain] Cd Length: 222 Bit Score: 114.01 E-value: 1.06e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 5 LEWDNLGFSLLpwIRTGLDVMGFETMTPVQASTIPMLAGNKDVVVDSVTGSGKTAAFVIPVLEKV-----VKEEANTSkf 79
Cdd:cd17953 12 QKWSQCGLSEK--VLDLIKKLGYEKPTPIQAQALPAIMSGRDVIGIAKTGSGKTLAFLLPMFRHIkdqrpVKPGEGPI-- 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 80 kkahfhSLIIAPTRELSRQIESVVLSFlehypSDLFPIKCQLLVGTNEatVRDDVSNfLRNRPQILIGTPGRVLDFLQMP 159
Cdd:cd17953 88 ------GLIMAPTRELALQIYVECKKF-----SKALGLRVVCVYGGSG--ISEQIAE-LKRGAEIVVCTPGRMIDILTAN 153
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 14318521 160 AVKTSA---CSMVVMDEADRLLDMSFIKDTEKILRLLPKQRRTGLFSATMRSAGSDIFKTGLRNPVRIT 225
Cdd:cd17953 154 NGRVTNlrrVTYVVLDEADRMFDMGFEPQIMKIVNNIRPDRQTVLFSATFPRKVEALARKVLHKPIEIT 222
|
|
| DEADc_DDX3 |
cd18051 |
DEAD-box helicase domain of DEAD box protein 3; DDX3 (also called helicase-like protein, DEAD ... |
18-205 |
5.15e-28 |
|
DEAD-box helicase domain of DEAD box protein 3; DDX3 (also called helicase-like protein, DEAD box, X isoform, or DDX14) has been reported to display a high level of RNA-independent ATPase activity stimulated by both RNA and DNA. This protein has multiple conserved domains and is thought to play roles in both the nucleus and cytoplasm. Nuclear roles include transcriptional regulation, mRNP assembly, pre-mRNA splicing, and mRNA export. In the cytoplasm, this protein is thought to be involved in translation, cellular signaling, and viral replication. Misregulation of this gene has been implicated in tumorigenesis. Diseases associated with DDX3 include mental retardation, X-linked 102 and agenesis of the corpus callosum, with facial anomalies and robin sequence. DDX3 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350809 [Multi-domain] Cd Length: 249 Bit Score: 112.83 E-value: 5.15e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 18 IRTGLDVMGFETMTPVQASTIPMLAGNKDVVVDSVTGSGKTAAFVIPVLEKVVKE--------EANTSKFKKAHFHSLII 89
Cdd:cd18051 32 IRNNIELARYTKPTPVQKHAIPIIKSKRDLMACAQTGSGKTAAFLLPILSQIYEQgpgeslpsESGYYGRRKQYPLALVL 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 90 APTRELSRQIESVVLSFleHYPSDLFPikCQLLVGTN-EATVRDdvsnfLRNRPQILIGTPGRVLDFLQMPAVKTSACSM 168
Cdd:cd18051 112 APTRELASQIYDEARKF--AYRSRVRP--CVVYGGADiGQQMRD-----LERGCHLLVATPGRLVDMLERGKIGLDYCKY 182
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 14318521 169 VVMDEADRLLDMSFIKDTEKILR---LLPK-QRRTGLFSAT 205
Cdd:cd18051 183 LVLDEADRMLDMGFEPQIRRIVEqdtMPPTgERQTLMFSAT 223
|
|
| DEADc_DDX5_DDX17 |
cd17966 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX5 and DDX17; DDX5 and DDX17 are ... |
25-205 |
1.55e-27 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX5 and DDX17; DDX5 and DDX17 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350724 [Multi-domain] Cd Length: 197 Bit Score: 109.77 E-value: 1.55e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 25 MGFETMTPVQASTIPMLAGNKDVVVDSVTGSGKTAAFVIPVLEKVVKEeantskfkkAHFHS------LIIAPTRELSRQ 98
Cdd:cd17966 8 QGFTEPTAIQAQGWPMALSGRDMVGIAQTGSGKTLAFLLPAIVHINAQ---------PPLERgdgpivLVLAPTRELAQQ 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 99 IESVVLSFlehypSDLFPIKCQLLVG--TNEATVRDdvsnfLRNRPQILIGTPGRVLDFLQMPAVKTSACSMVVMDEADR 176
Cdd:cd17966 79 IQQEANKF-----GGSSRLRNTCVYGgaPKGPQIRD-----LRRGVEICIATPGRLIDFLDQGKTNLRRVTYLVLDEADR 148
|
170 180
....*....|....*....|....*....
gi 14318521 177 LLDMSFIKDTEKILRLLPKQRRTGLFSAT 205
Cdd:cd17966 149 MLDMGFEPQIRKIVDQIRPDRQTLMWSAT 177
|
|
| DEADc_DDX39 |
cd17950 |
DEAD-box helicase domain of DEAD box protein 39; DDX39A is involved in pre-mRNA splicing and ... |
26-226 |
7.72e-27 |
|
DEAD-box helicase domain of DEAD box protein 39; DDX39A is involved in pre-mRNA splicing and is required for the export of mRNA out of the nucleus. DDX39B is an essential splicing factor required for association of U2 small nuclear ribonucleoprotein with pre-mRNA, and it also plays an important role in mRNA export from the nucleus to the cytoplasm. Diseases associated with DDX39A (also called UAP56-Related Helicase, 49 kDa) include gastrointestinal stromal tumor and inflammatory bowel disease 6, while diseases associated with DDX39B (also called 56 kDa U2AF65-Associated Protein) include Plasmodium vivax malaria. DDX39 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350708 [Multi-domain] Cd Length: 208 Bit Score: 108.20 E-value: 7.72e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 26 GFETMTPVQASTIPMLAGNKDVVVDSVTGSGKTAAFVIPVLEKVVKEEANTSkfkkahfhSLIIAPTRELSRQIESVVLS 105
Cdd:cd17950 21 GFEHPSEVQHECIPQAILGMDVLCQAKSGMGKTAVFVLSTLQQLEPVDGQVS--------VLVICHTRELAFQISNEYER 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 106 FLEHYPSdlfpIKCQLLV-GTNEATVRDDVSNflrNRPQILIGTPGRVLDFLQMPAVKTSACSMVVMDEADRLL-DMSFI 183
Cdd:cd17950 93 FSKYMPN----VKTAVFFgGVPIKKDIEVLKN---KCPHIVVGTPGRILALVREKKLKLSHVKHFVLDECDKMLeQLDMR 165
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 14318521 184 KDTEKILRLLPKQRRTGLFSATMRSAGSDIFKTGLRNPVRITV 226
Cdd:cd17950 166 RDVQEIFRATPHDKQVMMFSATLSKEIRPVCKKFMQDPLEIFV 208
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
247-365 |
2.78e-26 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 103.44 E-value: 2.78e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 247 EKLQLLVSILNNYKFKKCIVYFPTCVSVSyfysfIQYLGKRNilvnEVEIFSLHGKLQTSARTKTLTAFTDSLSNsVLFT 326
Cdd:pfam00271 1 EKLEALLELLKKERGGKVLIFSQTKKTLE-----AELLLEKE----GIKVARLHGDLSQEEREEILEDFRKGKID-VLVA 70
|
90 100 110
....*....|....*....|....*....|....*....
gi 14318521 327 TDVAARGIDIPDVDLVIQLDPPTNTDMFMHRCGRTGRAN 365
Cdd:pfam00271 71 TDVAERGLDLPDVDLVINYDLPWNPASYIQRIGRAGRAG 109
|
|
| DEADc_DDX51 |
cd17956 |
DEAD-box helicase domain of DEAD box protein 51; DDX51 aids cell cancer proliferation by ... |
22-221 |
4.73e-26 |
|
DEAD-box helicase domain of DEAD box protein 51; DDX51 aids cell cancer proliferation by regulating multiple signalling pathways. Mammalian DEAD box protein Ddx51 acts in 3' end maturation of 28S rRNA by promoting the release of U8 snoRNA.It is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350714 [Multi-domain] Cd Length: 231 Bit Score: 106.56 E-value: 4.73e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 22 LDVMGFETMTPVQASTIPM-LAGNK--------DVVVDSVTGSGKTAAFVIPVLEKVvkeeantSKFKKAHFHSLIIAPT 92
Cdd:cd17956 5 LQNNGITSAFPVQAAVIPWlLPSSKstppyrpgDLCVSAPTGSGKTLAYVLPIVQAL-------SKRVVPRLRALIVVPT 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 93 RELSRQIESVVLSFlehypSDLFPIKCQLLVGTN-----EATVRDDVSNFLRNRPQILIGTPGRVLDFLQM-PAVKTSAC 166
Cdd:cd17956 78 KELVQQVYKVFESL-----CKGTGLKVVSLSGQKsfkkeQKLLLVDTSGRYLSRVDILVATPGRLVDHLNStPGFTLKHL 152
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 14318521 167 SMVVMDEADRLLDMSF--------------------IKDTEKILRLLPKQRRTGLFSATMRSAGSDIFKTGLRNP 221
Cdd:cd17956 153 RFLVIDEADRLLNQSFqdwletvmkalgrptapdlgSFGDANLLERSVRPLQKLLFSATLTRDPEKLSSLKLHRP 227
|
|
| DEADc_EIF4AIII_DDX48 |
cd18045 |
DEAD-box helicase domain of eukaryotic initiation factor 4A-III; Eukaryotic initiation factor ... |
21-224 |
7.28e-26 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A-III; Eukaryotic initiation factor 4A-III (EIF4AIII, also known as DDX48) is part of the exon junction complex (EJC) that plays a major role in posttranscriptional regulation of mRNA. EJC consists of four proteins (eIF4AIII, Barentsz [Btz], Mago, and Y14), mRNA, and ATP. DDX48 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350803 [Multi-domain] Cd Length: 201 Bit Score: 105.24 E-value: 7.28e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 21 GLDVMGFETMTPVQASTIPMLAGNKDVVVDSVTGSGKTAAFVIPVLEKV---VKEEantskfkkahfHSLIIAPTRELSR 97
Cdd:cd18045 13 GIYAYGFEKPSAIQQRAIKPIIKGRDVIAQSQSGTGKTATFSISVLQCLdiqVRET-----------QALILSPTRELAV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 98 QIESVVLSFlehypSDLFPIKCQLLVGTNeaTVRDDVSNfLRNRPQILIGTPGRVLDFLQMPAVKTSACSMVVMDEADRL 177
Cdd:cd18045 82 QIQKVLLAL-----GDYMNVQCHACIGGT--SVGDDIRK-LDYGQHIVSGTPGRVFDMIRRRSLRTRHIKMLVLDEADEM 153
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 14318521 178 LDMSFIKDTEKILRLLPKQRRTGLFSATMRSAGSDIFKTGLRNPVRI 224
Cdd:cd18045 154 LNKGFKEQIYDVYRYLPPATQVVLVSATLPQDILEMTNKFMTDPIRI 200
|
|
| DEADc_DDX43_DDX53 |
cd17958 |
DEAD-box helicase domain of DEAD box proteins 43 and 53; DDX43 (also called cancer/testis ... |
25-225 |
1.20e-24 |
|
DEAD-box helicase domain of DEAD box proteins 43 and 53; DDX43 (also called cancer/testis antigen 13 or helical antigen) displays tumor-specific expression. Diseases associated with DDX43 include rheumatoid lung disease. DDX53 is also called cancer/testis antigen 26 or DEAD-Box Protein CAGE. Both DDX46 and DDX53 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350716 [Multi-domain] Cd Length: 197 Bit Score: 101.77 E-value: 1.20e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 25 MGFETMTPVQASTIPMLAGNKDVVVDSVTGSGKTAAFVIPVLEKVVKEEanTSKFKKAHFHSLIIAPTRELSRQIESVVL 104
Cdd:cd17958 8 QGFEKPSPIQSQAWPIILQGIDLIGVAQTGTGKTLAYLLPGFIHLDLQP--IPREQRNGPGVLVLTPTRELALQIEAECS 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 105 SFLEHypsdlfPIKCQLLVGtneATVRDDVSNFLRNRPQILIGTPGRVLDFLQMPAVKTSACSMVVMDEADRLLDMSFIK 184
Cdd:cd17958 86 KYSYK------GLKSVCVYG---GGNRNEQIEDLSKGVDIIIATPGRLNDLQMNNVINLKSITYLVLDEADRMLDMGFEP 156
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 14318521 185 DTEKILRLLPKQRRTGLFSATMRSAGSDIFKTGLRNPVRIT 225
Cdd:cd17958 157 QIRKILLDIRPDRQTIMTSATWPDGVRRLAQSYLKDPMIVY 197
|
|
| DEADc_DDX28 |
cd17948 |
DEAD-box helicase domain of DEAD box protein 28; DDX28 (also called mitochondrial DEAD-box ... |
22-213 |
2.02e-23 |
|
DEAD-box helicase domain of DEAD box protein 28; DDX28 (also called mitochondrial DEAD-box polypeptide 28) plays an essential role in facilitating the proper assembly of the mitochondrial large ribosomal subunit and its helicase activity is essential for this function. DDX28 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350706 [Multi-domain] Cd Length: 231 Bit Score: 98.98 E-value: 2.02e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 22 LDVMGFETMTPVQASTIPMLAGNKDVVVDSVTGSGKTAAFVIPVLEKVVKEEANTSKfKKAHFHSLIIAPTRELSRQIES 101
Cdd:cd17948 5 LQRQGITKPTTVQKQGIPSILRGRNTLCAAETGSGKTLTYLLPIIQRLLRYKLLAEG-PFNAPRGLVITPSRELAEQIGS 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 102 VVLSFLEHypsdlFPIKCQLLVGTNeaTVRdDVSNFLRNRPQILIGTPGRVLDFLQMPAVKTSACSMVVMDEADRLLDMS 181
Cdd:cd17948 84 VAQSLTEG-----LGLKVKVITGGR--TKR-QIRNPHFEEVDILVATPGALSKLLTSRIYSLEQLRHLVLDEADTLLDDS 155
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 14318521 182 FIKDTEKILRLLPKQRRTG-------------LFSATMRSAGSDI 213
Cdd:cd17948 156 FNEKLSHFLRRFPLASRRSentdgldpgtqlvLVSATMPSGVGEV 200
|
|
| DEADc_DDX17 |
cd18050 |
DEAD-box helicase domain of DEAD box protein 17; DDX17 (also called DEAD Box Protein P72 or ... |
22-226 |
2.94e-21 |
|
DEAD-box helicase domain of DEAD box protein 17; DDX17 (also called DEAD Box Protein P72 or DEAD Box Protein P82) has a wide variety of functions including regulating the alternative splicing of exons exhibiting specific features such as the inclusion of AC-rich alternative exons in CD44 transcripts, playing a role in innate immunity, and promoting mRNA degradation mediated by the antiviral zinc-finger protein ZC3HAV1 in an ATPase-dependent manner. DDX17 synergizes with DDX5 and SRA1 RNA to activate MYOD1 transcriptional activity and is involved in skeletal muscle differentiation. DDX17 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350808 [Multi-domain] Cd Length: 271 Bit Score: 93.92 E-value: 2.94e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 22 LDVM---GFETMTPVQASTIPMLAGNKDVVVDSVTGSGKTAAFVIPVLEKVVKE---EANTSKFkkahfhSLIIAPTREL 95
Cdd:cd18050 74 MDVLldqNFKEPTPIQCQGFPLALSGRDMVGIAQTGSGKTLAYLLPAIVHINHQpylERGDGPI------CLVLAPTREL 147
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 96 SRQIESVVLSFLEhypSDLFPIKCQLLVGTNEATVRDdvsnfLRNRPQILIGTPGRVLDFLQMPAVKTSACSMVVMDEAD 175
Cdd:cd18050 148 AQQVQQVADDYGK---SSRLKSTCIYGGAPKGPQIRD-----LERGVEICIATPGRLIDFLEAGKTNLRRCTYLVLDEAD 219
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 14318521 176 RLLDMSFIKDTEKILRLLPKQRRTGLFSATMRSAGSDIFKTGLRNPVRITV 226
Cdd:cd18050 220 RMLDMGFEPQIRKIVDQIRPDRQTLMWSATWPKEVRQLAEDFLRDYVQINI 270
|
|
| DEADc_DDX5 |
cd18049 |
DEAD-box helicase domain of DEAD box protein 5; DDX5 (also called RNA helicase P68, HLR1, ... |
27-228 |
1.35e-20 |
|
DEAD-box helicase domain of DEAD box protein 5; DDX5 (also called RNA helicase P68, HLR1, G17P1, or HUMP68) is involved in pathways that include the alteration of RNA structures, plays a role as a coregulator of transcription, a regulator of splicing, and in the processing of small noncoding RNAs. It synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and is involved in skeletal muscle differentiation. Dysregulation of this gene may play a role in cancer development. DDX5 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350807 [Multi-domain] Cd Length: 234 Bit Score: 91.22 E-value: 1.35e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 27 FETMTPVQASTIPMLAGNKDVVVDSVTGSGKTAAFVIPVLEKVvkeeaNTSKFKKAHFHS--LIIAPTRELSRQIESVVL 104
Cdd:cd18049 44 FTEPTAIQAQGWPVALSGLDMVGVAQTGSGKTLSYLLPAIVHI-----NHQPFLERGDGPicLVLAPTRELAQQVQQVAA 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 105 sflEHYPSDLFPIKCQLLVGTNEATVRDdvsnfLRNRPQILIGTPGRVLDFLQMPAVKTSACSMVVMDEADRLLDMSFIK 184
Cdd:cd18049 119 ---EYGRACRLKSTCIYGGAPKGPQIRD-----LERGVEICIATPGRLIDFLEAGKTNLRRCTYLVLDEADRMLDMGFEP 190
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 14318521 185 DTEKILRLLPKQRRTGLFSATMRSAGSDIFKTGLRNPVRITVNS 228
Cdd:cd18049 191 QIRKIVDQIRPDRQTLMWSATWPKEVRQLAEDFLKDYIHINIGA 234
|
|
| DEADc_MRH4 |
cd17965 |
DEAD-box helicase domain of ATP-dependent RNA helicase MRH4; Mitochondrial RNA helicase 4 ... |
31-205 |
1.60e-20 |
|
DEAD-box helicase domain of ATP-dependent RNA helicase MRH4; Mitochondrial RNA helicase 4 (MRH4) plays an essential role during the late stages of mitochondrial ribosome or mitoribosome assembly by promoting remodeling of the 21S rRNA-protein interactions. MRH4 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350723 [Multi-domain] Cd Length: 251 Bit Score: 91.28 E-value: 1.60e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 31 TPVQASTIPMLAGN----------------KDVVVDSVTGSGKTAAFVIPVLEKVVKEEANTSKFKKAHFH--------- 85
Cdd:cd17965 32 SPIQTLAIKKLLKTlmrkvtkqtsneepklEVFLLAAETGSGKTLAYLAPLLDYLKRQEQEPFEEAEEEYEsakdtgrpr 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 86 SLIIAPTRELSRQIESVVLSFLEHYPSDLFPIKcqllvgTNEATVRDDVSNFLRNRPQILIGTPGRVLDFLQMPAVKTSA 165
Cdd:cd17965 112 SVILVPTHELVEQVYSVLKKLSHTVKLGIKTFS------SGFGPSYQRLQLAFKGRIDILVTTPGKLASLAKSRPKILSR 185
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 14318521 166 CSMVVMDEADRLLDMSFIKDTEKILRLLPKQRRTGLFSAT 205
Cdd:cd17965 186 VTHLVVDEADTLFDRSFLQDTTSIIKRAPKLKHLILCSAT 225
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
282-365 |
2.28e-20 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 85.73 E-value: 2.28e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 282 QYLGKRNIlvnevEIFSLHGKLQTSARTKTLTAFTDSLSNsVLFTTDVAARGIDIPDVDLVIQLDPPTNTDMFMHRCGRT 361
Cdd:smart00490 5 ELLKELGI-----KVARLHGGLSQEEREEILDKFNNGKIK-VLVATDVAERGLDLPGVDLVIIYDLPWSPASYIQRIGRA 78
|
....
gi 14318521 362 GRAN 365
Cdd:smart00490 79 GRAG 82
|
|
| DEADc_DDX21_DDX50 |
cd17944 |
DEAD-box helicase domain of DEAD box proteins 21 and 50; DDX21 (also called Gu-Alpha and ... |
22-205 |
2.95e-20 |
|
DEAD-box helicase domain of DEAD box proteins 21 and 50; DDX21 (also called Gu-Alpha and nucleolar RNA helicase 2) is an RNA helicase that acts as a sensor of the transcriptional status of both RNA polymerase (Pol) I and II. It promotes ribosomal RNA (rRNA) processing and transcription from polymerase II (Pol II) and binds various RNAs, such as rRNAs, snoRNAs, 7SK and, at lower extent, mRNAs. DDX50 (also called Gu-Beta, Nucleolar Protein Gu2, and malignant cell derived RNA helicase). DDX21 and DDX50 have similar genomic structures and are in tandem orientation on chromosome 10, suggesting that the two genes arose by gene duplication in evolution. Diseases associated with DDX21 include stomach disease and cerebral creatine deficiency syndrome 3. Diseases associated with DDX50 include rectal disease. Both are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. Their name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP- binding region.
Pssm-ID: 350702 [Multi-domain] Cd Length: 202 Bit Score: 89.14 E-value: 2.95e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 22 LDVMGFETMTPVQASTIPMLAGNKDVVVDSVTGSGKTAAFVIPVLEKVVKEEANTSKFKKAHFhsLIIAPTRELSRQIEs 101
Cdd:cd17944 5 LQARGVTYLFPIQVKTFHPVYSGKDLIAQARTGTGKTFSFAIPLIEKLQEDQQPRKRGRAPKV--LVLAPTRELANQVT- 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 102 vvlsflehypSDLFPIKCQLLVGT-NEATVRDDVSNFLRNRPQILIGTPGRVLDFLQMPAVKTSACSMVVMDEADRLLDM 180
Cdd:cd17944 82 ----------KDFKDITRKLSVACfYGGTPYQQQIFAIRNGIDILVGTPGRIKDHLQNGRLDLTKLKHVVLDEVDQMLDM 151
|
170 180 190
....*....|....*....|....*....|
gi 14318521 181 SFIKDTEKILRLLPKQR-----RTGLFSAT 205
Cdd:cd17944 152 GFAEQVEEILSVSYKKDsednpQTLLFSAT 181
|
|
| DUF4217 |
pfam13959 |
Domain of unknown function (DUF4217); This short domain is found at the C-terminus of many ... |
409-466 |
1.97e-19 |
|
Domain of unknown function (DUF4217); This short domain is found at the C-terminus of many helicase proteins.
Pssm-ID: 464056 [Multi-domain] Cd Length: 59 Bit Score: 82.06 E-value: 1.97e-19
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*...
gi 14318521 409 EDFRNWILEDRDRFDKGVKAYVAFIKYYSNHSATSIFRLQSLDYVGIAKLYGLFRLPR 466
Cdd:pfam13959 2 LQLEKLVLKDRELKELAQKAFVSYVRAYSKHLAKSIFNVKKLDLGHLAKSFGLLRAPK 59
|
|
| DEADc_DDX25 |
cd18048 |
DEAD-box helicase domain of DEAD box protein 25; DDX25 (also called gonadotropin-regulated ... |
21-205 |
3.76e-16 |
|
DEAD-box helicase domain of DEAD box protein 25; DDX25 (also called gonadotropin-regulated testicular RNA helicase (GRTH) is a testis-specific protein essential for completion of spermatogenesis. DDX25 is also a novel negative regulator of IFN pathway and facilitates RNA virus infection. Diseases associated with DDX25 include hydrolethalus syndrome, an autosomal recessive lethal malformation syndrome characterized by multiple developmental defects of fetus.. DDX25 (also called gonadotropin-regulated testicular RNA helicase) is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350806 [Multi-domain] Cd Length: 229 Bit Score: 78.14 E-value: 3.76e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 21 GLDVMGFETMTPVQASTIPMLAGN--KDVVVDSVTGSGKTAAFVIPVLEKVvkeeantsKFKKAHFHSLIIAPTRELSRQ 98
Cdd:cd18048 32 GIYAMGFNRPSKIQENALPMMLADppQNLIAQSQSGTGKTAAFVLAMLSRV--------DALKLYPQCLCLSPTFELALQ 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 99 IESVVlsflEHYPSDLFPIKCQLLVGTNEATVRDDVSnflrnrPQILIGTPGRVLDF-LQMPAVKTSACSMVVMDEADRL 177
Cdd:cd18048 104 TGKVV----EEMGKFCVGIQVIYAIRGNRPGKGTDIE------AQIVIGTPGTVLDWcFKLRLIDVTNISVFVLDEADVM 173
|
170 180
....*....|....*....|....*....
gi 14318521 178 LDMSFIKD-TEKILRLLPKQRRTGLFSAT 205
Cdd:cd18048 174 INVQGHSDhSVRVKRSMPKECQMLLFSAT 202
|
|
| DEADc_DDX19 |
cd18047 |
DEAD-box helicase domain of DEAD box protein 19; DDX19 is an RNA helicase involved in both ... |
14-209 |
9.53e-16 |
|
DEAD-box helicase domain of DEAD box protein 19; DDX19 is an RNA helicase involved in both mRNA (mRNA) export from the nucleus into the cytoplasm and in mRNA translation. DDX19 functions in the nucleus in resolving RNA:DNA hybrids (R-loops). Activation of a DNA damage response pathway dependent upon the ATR kinase, a major regulator of replication fork progression, stimulates translocation of DDX19 from the cytoplasm into the nucleus. Only nuclear Ddx19 is competent to resolve R-loops. DDX19 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350805 [Multi-domain] Cd Length: 205 Bit Score: 76.30 E-value: 9.53e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 14 LLPWIRTGLDVMGFETMTPVQASTIPMLAGN--KDVVVDSVTGSGKTAAFVIPVLEKVvkeeANTSKFKKAhfhsLIIAP 91
Cdd:cd18047 8 LKPQLLQGVYAMGFNRPSKIQENALPLMLAEppQNLIAQSQSGTGKTAAFVLAMLSQV----EPANKYPQC----LCLSP 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 92 TRELSRQIESVVLSFLEHYPSdlfpikcqllVGTNEATVRDDVSNFLRNRPQILIGTPGRVLDF-LQMPAVKTSACSMVV 170
Cdd:cd18047 80 TYELALQTGKVIEQMGKFYPE----------LKLAYAVRGNKLERGQKISEQIVIGTPGTVLDWcSKLKFIDPKKIKVFV 149
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 14318521 171 MDEADRLLDMSFIKDTE-KILRLLPKQRRTGLFSATMRSA 209
Cdd:cd18047 150 LDEADVMIATQGHQDQSiRIQRMLPRNCQMLLFSATFEDS 189
|
|
| SSL2 |
COG1061 |
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair]; |
42-375 |
2.51e-15 |
|
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
Pssm-ID: 440681 [Multi-domain] Cd Length: 566 Bit Score: 79.30 E-value: 2.51e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 42 AGNKDVVVDSVTGSGKT--AAFVIpvlekvvkeeANTSKFKKAhfhsLIIAPTRELSRQIESVVLSFL--EHYPSDLFPI 117
Cdd:COG1061 98 RGGGRGLVVAPTGTGKTvlALALA----------AELLRGKRV----LVLVPRRELLEQWAEELRRFLgdPLAGGGKKDS 163
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 118 KCQLLVGTNEATVRDDVSNFLRNRpqiligtpgrvldflqmpavktsaCSMVVMDEADRLLDMSFikdtEKILRLLPKQR 197
Cdd:COG1061 164 DAPITVATYQSLARRAHLDELGDR------------------------FGLVIIDEAHHAGAPSY----RRILEAFPAAY 215
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 198 RTGLfSATM-RSAGSDI---------FKTGLRN-------------PVRITVNSKNQAPSSLK--LNYCVVNPAE-KLQL 251
Cdd:COG1061 216 RLGL-TATPfRSDGREIllflfdgivYEYSLKEaiedgylappeyyGIRVDLTDERAEYDALSerLREALAADAErKDKI 294
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 252 LVSILNNY-KFKKCIVYfptCVSVSYFYSFIQYLGKRNIlvnevEIFSLHGKLQTSARTKTLTAFTDSLSNsVLFTTDVA 330
Cdd:COG1061 295 LRELLREHpDDRKTLVF---CSSVDHAEALAELLNEAGI-----RAAVVTGDTPKKEREEILEAFRDGELR-ILVTVDVL 365
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 14318521 331 ARGIDIPDVDLVIQLDPPTNTDMFMHRCGRTGRANRVGKAITFLN 375
Cdd:COG1061 366 NEGVDVPRLDVAILLRPTGSPREFIQRLGRGLRPAPGKEDALVYD 410
|
|
| SF2-N |
cd00046 |
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ... |
44-205 |
1.74e-12 |
|
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.
Pssm-ID: 350668 [Multi-domain] Cd Length: 146 Bit Score: 65.12 E-value: 1.74e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 44 NKDVVVDSVTGSGKTAAFVIPVLekvvkeeantSKFKKAHFHSLIIAPTRELSRQIESVVLSFLEHypsdlfPIKCQLLV 123
Cdd:cd00046 1 GENVLITAPTGSGKTLAALLAAL----------LLLLKKGKKVLVLVPTKALALQTAERLRELFGP------GIRVAVLV 64
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 124 GtnEATVRDDVSNFLRNrPQILIGTPGRVL-DFLQMPAVKTSACSMVVMDEADRLLDMSFIKDTEK--ILRLLPKQRRTG 200
Cdd:cd00046 65 G--GSSAEEREKNKLGD-ADIIIATPDMLLnLLLREDRLFLKDLKLIIVDEAHALLIDSRGALILDlaVRKAGLKNAQVI 141
|
....*
gi 14318521 201 LFSAT 205
Cdd:cd00046 142 LLSAT 146
|
|
| SF2_C |
cd18785 |
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ... |
322-373 |
1.43e-09 |
|
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350172 [Multi-domain] Cd Length: 77 Bit Score: 54.63 E-value: 1.43e-09
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 14318521 322 SVLFTTDVAARGIDIPDVDLVIQLDPPTNTDMFMHRCGRTGR-ANRVGKAITF 373
Cdd:cd18785 24 EILVATNVLGEGIDVPSLDTVIFFDPPSSAASYIQRVGRAGRgGKDEGEVILF 76
|
|
| DEXHc_Hrq1-like |
cd17923 |
DEAH-box helicase domain of Hrq1 and similar proteins; Yeast Hrq1, similar to RecQ4, plays a ... |
34-149 |
2.61e-09 |
|
DEAH-box helicase domain of Hrq1 and similar proteins; Yeast Hrq1, similar to RecQ4, plays a role in DNA inter-strand crosslink (ICL) repair and in telomere maintenance. Hrq1 lacks the Sld2-like domain found in RecQ4. Hrq1 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350681 [Multi-domain] Cd Length: 182 Bit Score: 56.82 E-value: 2.61e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 34 QASTIPMLAGNKDVVVDSVTGSGKTAAFVIPVLEKVVKEEANTskfkkahfhSLIIAPTRELSRQIESVVLSFLEhypSD 113
Cdd:cd17923 5 QAEAIEAARAGRSVVVTTGTASGKSLCYQLPILEALLRDPGSR---------ALYLYPTKALAQDQLRSLRELLE---QL 72
|
90 100 110
....*....|....*....|....*....|....*.
gi 14318521 114 LFPIKCQLLVGTNEATVRDDVsnfLRNRPQILIGTP 149
Cdd:cd17923 73 GLGIRVATYDGDTPREERRAI---IRNPPRILLTNP 105
|
|
| SF2_C_dicer |
cd18802 |
C-terminal helicase domain of the endoribonuclease Dicer; Dicer ribonucleases cleave ... |
245-365 |
9.80e-09 |
|
C-terminal helicase domain of the endoribonuclease Dicer; Dicer ribonucleases cleave double-stranded RNA (dsRNA) precursors to generate microRNAs (miRNAs) and small interfering RNAs (siRNAs). In concert with Argonautes, these small RNAs bind complementary mRNAs to down-regulate their expression. miRNAs are processed by Dicer from small hairpins, while siRNAs are typically processed from longer dsRNA, from endogenous sources, or exogenous sources such as viral replication intermediates. Some organisms, such as Homo sapiens and Caenorhabditis elegans, encode one Dicer that generates miRNAs and siRNAs, but other organisms have multiple dicers with specialized functions. Dicer exists throughout eukaryotes, and a subset has an N-terminal helicase domain of the RIG-I-like receptor (RLR) subgroup. RLRs often function in innate immunity and Dicer helicase domains sometimes show differences in activity that correlate with roles in immunity. Dicer helicase domains are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350189 [Multi-domain] Cd Length: 142 Bit Score: 54.13 E-value: 9.80e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 245 PAEKLQLLVSILNNYKFK----KCIVYFPTCVSVSYFYSFIQYLGKR------NILV-----NEVEIFSLHGKLQTSart 309
Cdd:cd18802 5 VIPKLQKLIEILREYFPKtpdfRGIIFVERRATAVVLSRLLKEHPSTlafircGFLIgrgnsSQRKRSLMTQRKQKE--- 81
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 14318521 310 kTLTAFTDSLSNsVLFTTDVAARGIDIPDVDLVIQLDPPTNTDMFMHRCGRTGRAN 365
Cdd:cd18802 82 -TLDKFRDGELN-LLIATSVLEEGIDVPACNLVIRFDLPKTLRSYIQSRGRARAPN 135
|
|
| YprA |
COG1205 |
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, ... |
18-174 |
7.06e-08 |
|
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, recombination and repair];
Pssm-ID: 440818 [Multi-domain] Cd Length: 758 Bit Score: 55.61 E-value: 7.06e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 18 IRTGLDVMGFETMTPVQASTIPMLAGNKDVVVDSVTGSGKTAAFVIPVLEKVVKEEANTskfkkahfhSLIIAPTRELSR 97
Cdd:COG1205 45 LRAALKKRGIERLYSHQAEAIEAARAGKNVVIATPTASGKSLAYLLPVLEALLEDPGAT---------ALYLYPTKALAR 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 98 -QIESvVLSFLEHYPSDlfpIKCQLLVGTNEATVRDDVsnflRNRPQILIGTPgrvlDFL--QMPAVKT------SACSM 168
Cdd:COG1205 116 dQLRR-LRELAEALGLG---VRVATYDGDTPPEERRWI----REHPDIVLTNP----DMLhyGLLPHHTrwarffRNLRY 183
|
....*.
gi 14318521 169 VVMDEA 174
Cdd:COG1205 184 VVIDEA 189
|
|
| SF2_C_LHR |
cd18796 |
C-terminal helicase domain of LHR family helicases; Large helicase-related protein (LHR) is a ... |
279-371 |
3.87e-07 |
|
C-terminal helicase domain of LHR family helicases; Large helicase-related protein (LHR) is a DNA damage-inducible helicase that uses ATP hydrolysis to drive unidirectional 3'-to-5' translocation along single-stranded DNA (ssDNA) and to unwind RNA:DNA duplexes. This group also includes related bacterial and archaeal helicases. LHR family helicases are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350183 [Multi-domain] Cd Length: 150 Bit Score: 49.96 E-value: 3.87e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 279 SFIQYLGKRN-ILVNEVEIFSLHGKLQTSARTKTLTAFTDSLSNSVLFTT--DVaarGIDIPDVDLVIQLDPPTNTDMFM 355
Cdd:cd18796 53 RLAQRLRELCpDRVPPDFIALHHGSLSRELREEVEAALKRGDLKVVVATSslEL---GIDIGDVDLVIQIGSPKSVARLL 129
|
90
....*....|....*.
gi 14318521 356 HRCGRTGRanRVGKAI 371
Cdd:cd18796 130 QRLGRSGH--RPGAAS 143
|
|
| SF2_C_SNF |
cd18793 |
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) ... |
248-368 |
1.50e-06 |
|
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) family includes chromatin-remodeling factors, such as CHD proteins and SMARCA proteins, recombination proteins Rad54, and many others. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350180 [Multi-domain] Cd Length: 135 Bit Score: 47.86 E-value: 1.50e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 248 KLQLLVSILNNYKFK--KCIVYfptcvsvSYFYSFIQYLGKRnILVNEVEIFSLHGKLQTSARTKTLTAFTDSLSNSVLF 325
Cdd:cd18793 12 KLEALLELLEELREPgeKVLIF-------SQFTDTLDILEEA-LRERGIKYLRLDGSTSSKERQKLVDRFNEDPDIRVFL 83
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 14318521 326 -TTDVAARGIDIPDVDLVIQLDPPTNTDMFMHrcgRTGRANRVG 368
Cdd:cd18793 84 lSTKAGGVGLNLTAANRVILYDPWWNPAVEEQ---AIDRAHRIG 124
|
|
| DEXHc_LHR-like |
cd17922 |
DEXH-box helicase domain of LHR; Large helicase-related protein (LHR) is a DNA ... |
44-149 |
1.01e-05 |
|
DEXH-box helicase domain of LHR; Large helicase-related protein (LHR) is a DNA damage-inducible helicase that uses ATP hydrolysis to drive unidirectional 3'-to-5' translocation along single-stranded DNA (ssDNA) and to unwind RNA:DNA duplexes. This group also includes related bacterial and archaeal helicases from the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350680 [Multi-domain] Cd Length: 166 Bit Score: 46.04 E-value: 1.01e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 44 NKDVVVDSVTGSGKTAAFVIPVLEKVVKEEANTskfkkahFHSLIIAPTRELSRQIESVVLSFLEHYpsdLFPIKCQLLV 123
Cdd:cd17922 1 GRNVLIAAPTGSGKTEAAFLPALSSLADEPEKG-------VQVLYISPLKALINDQERRLEEPLDEI---DLEIPVAVRH 70
|
90 100
....*....|....*....|....*.
gi 14318521 124 GTNEATVRddvSNFLRNRPQILIGTP 149
Cdd:cd17922 71 GDTSQSEK---AKQLKNPPGILITTP 93
|
|
| MPH1 |
COG1111 |
ERCC4-related helicase [Replication, recombination and repair]; |
249-380 |
1.42e-05 |
|
ERCC4-related helicase [Replication, recombination and repair];
Pssm-ID: 440728 [Multi-domain] Cd Length: 718 Bit Score: 48.19 E-value: 1.42e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 249 LQLLVSILNNYKFKKCIV---YFPTCVSVsyfysfIQYLGKRNIlvnEVEIFSLHGKLQTSA------RTKTLTAFTDSL 319
Cdd:COG1111 341 REILKEQLGTNPDSRIIVftqYRDTAEMI------VEFLSEPGI---KAGRFVGQASKEGDKgltqkeQIEILERFRAGE 411
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 14318521 320 SNsVLFTTDVAARGIDIPDVDLVIQLDPPTNTDMFMHRCGRTGRaNRVGKAITFLNEG-REE 380
Cdd:COG1111 412 FN-VLVATSVAEEGLDIPEVDLVIFYEPVPSEIRSIQRKGRTGR-KREGRVVVLIAKGtRDE 471
|
|
| SF2_C_FANCM_Hef |
cd18801 |
C-terminal helicase domain of Fanconi anemia group M family helicases; Fanconi anemia group M ... |
322-374 |
3.72e-05 |
|
C-terminal helicase domain of Fanconi anemia group M family helicases; Fanconi anemia group M (FANCM) protein is a DNA-dependent ATPase component of the Fanconi anemia (FA) core complex. It is required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. Hef (helicase-associated endonuclease fork-structure) belongs to the XPF/MUS81/FANCM family of endonucleases and is involved in stalled replication fork repair. FANCM and Hef are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350188 [Multi-domain] Cd Length: 143 Bit Score: 43.88 E-value: 3.72e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 14318521 322 SVLFTTDVAARGIDIPDVDLVIQLDPPTNTDMFMHRCGRTGRaNRVGKAITFL 374
Cdd:cd18801 92 NVLVATSIGEEGLDIGEVDLIICYDASPSPIRMIQRMGRTGR-KRQGRVVVLL 143
|
|
| BRR2 |
COG1204 |
Replicative superfamily II helicase [Replication, recombination and repair]; |
14-223 |
3.73e-05 |
|
Replicative superfamily II helicase [Replication, recombination and repair];
Pssm-ID: 440817 [Multi-domain] Cd Length: 529 Bit Score: 46.43 E-value: 3.73e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 14 LLPWIRTGLDVMGFETMTPVQASTIPM-LAGNKDVVVDSVTGSGKTAafvipVLEKVVKEEANTSkfKKAhfhsLIIAPT 92
Cdd:COG1204 7 PLEKVIEFLKERGIEELYPPQAEALEAgLLEGKNLVVSAPTASGKTL-----IAELAILKALLNG--GKA----LYIVPL 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 93 R--------ELSRQIE----SVVLSFLEHYPSDLFPIKCQLLVGTNEatvRDDvsNFLRNRPQILIgtpgrvlDFlqmpa 160
Cdd:COG1204 76 RalasekyrEFKRDFEelgiKVGVSTGDYDSDDEWLGRYDILVATPE---KLD--SLLRNGPSWLR-------DV----- 138
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 14318521 161 vktsacSMVVMDEA------DR--LLDMSfikdTEKILRLLPKQRRTGLfSATMRSA-------GSDIFKTGLRnPVR 223
Cdd:COG1204 139 ------DLVVVDEAhliddeSRgpTLEVL----LARLRRLNPEAQIVAL-SATIGNAeeiaewlDAELVKSDWR-PVP 204
|
|
| PRK13766 |
PRK13766 |
Hef nuclease; Provisional |
322-380 |
1.20e-04 |
|
Hef nuclease; Provisional
Pssm-ID: 237496 [Multi-domain] Cd Length: 773 Bit Score: 45.25 E-value: 1.20e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 14318521 322 SVLFTTDVAARGIDIPDVDLVIQLDP-PTNTDMfMHRCGRTGRaNRVGKAITFLNEG-REE 380
Cdd:PRK13766 425 NVLVSTSVAEEGLDIPSVDLVIFYEPvPSEIRS-IQRKGRTGR-QEEGRVVVLIAKGtRDE 483
|
|
| Cas3_I |
cd09639 |
CRISPR/Cas system-associated protein Cas3; CRISPR (Clustered Regularly Interspaced Short ... |
46-366 |
3.77e-04 |
|
CRISPR/Cas system-associated protein Cas3; CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; DEAD/DEAH box helicase DNA helicase cas3'; Often but not always is fused to HD nuclease domain; signature gene for Type I
Pssm-ID: 187770 [Multi-domain] Cd Length: 353 Bit Score: 43.19 E-value: 3.77e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 46 DVVVDSVTGSGKT-AAFVIpvlekvvkeeANTSkFKKAHFHSLIIA-PTRELSRQI-ESVVLSF--------------LE 108
Cdd:cd09639 1 LLVIEAPTGYGKTeAALLW----------ALHS-LKSQKADRVIIAlPTRATINAMyRRAKEAFgetglyhssilssrIK 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 109 HYPSDLFPIKCQLLVGTNEATVrddvsnFLRnrpQILIGTPGRVLDFLqMPAVKTS-------ACSMVVMDEADRLLDms 181
Cdd:cd09639 70 EMGDSEEFEHLFPLYIHSNDTL------FLD---PITVCTIDQVLKSV-FGEFGHYeftlasiANSLLIFDEVHFYDE-- 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 182 FIKdtEKILRLLPKQRRTG----LFSATM--------RSAGSDIFKTGL-RNPVRITVNSKnqapsslklnyCVVNPAEK 248
Cdd:cd09639 138 YTL--ALILAVLEVLKDNDvpilLMSATLpkflkeyaEKIGYVEENEPLdLKPNERAPFIK-----------IESDKVGE 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 249 LQLLVSILNNY-KFKKCIVYFPTCVSVSYFYSFIqylgkrNILVNEVEIFSLHGKLQTSARTKTLTAFTDSLSNS---VL 324
Cdd:cd09639 205 ISSLERLLEFIkKGGSVAIIVNTVDRAQEFYQQL------KEKGPEEEIMLIHSRFTEKDRAKKEAELLLEFKKSekfVI 278
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 14318521 325 FTTDVAARGIDIpDVDLVI-QLDPPtntDMFMHRCGRTGRANR 366
Cdd:cd09639 279 VATQVIEASLDI-SVDVMItELAPI---DSLIQRLGRLHRYGE 317
|
|
| SF2_C_EcoAI-like |
cd18799 |
C-terminal helicase domain of EcoAI HsdR-like restriction enzyme family helicases; This family ... |
259-350 |
2.67e-03 |
|
C-terminal helicase domain of EcoAI HsdR-like restriction enzyme family helicases; This family is composed of helicase restriction enzymes, including the HsdR subunit of restriction-modification enzymes such as Escherichia coli type I restriction enzyme EcoAI R protein (R.EcoAI). The EcoAI enzyme recognizes 5'-GAGN(7)GTCA-3'. The HsdR or R subunit is required for both nuclease and ATPase activities, but not for modification. These proteins are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350186 [Multi-domain] Cd Length: 116 Bit Score: 37.92 E-value: 2.67e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 259 YKFKKCIVYfptCVSVSYFYSFIQYLGKRNIlvNEVEIFSLHGKLQTSARTKTLTaFTDSLSNSVLFTTDVAARGIDIPD 338
Cdd:cd18799 4 YVEIKTLIF---CVSIEHAEFMAEAFNEAGI--DAVALNSDYSDRERGDEALILL-FFGELKPPILVTVDLLTTGVDIPE 77
|
90
....*....|..
gi 14318521 339 VDLVIqLDPPTN 350
Cdd:cd18799 78 VDNVV-FLRPTE 88
|
|
| SF2_C_XPB |
cd18789 |
C-terminal helicase domain of XPB-like helicases; TFIIH basal transcription factor complex ... |
237-345 |
5.02e-03 |
|
C-terminal helicase domain of XPB-like helicases; TFIIH basal transcription factor complex helicase XPB (xeroderma pigmentosum type B) subunit (also known as DNA excision repair protein ERCC-3 or TFIIH 89 kDa subunit) is the ATP-dependent 3'-5' DNA helicase component of the core-TFIIH basal transcription factor, involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. XPB is a DEAD-like helicase belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350176 [Multi-domain] Cd Length: 153 Bit Score: 38.00 E-value: 5.02e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318521 237 KLNYCVVNPAeKLQLLVSILNNYK-FKKCIVyFPTCVSVSYFYSfiQYLGKRNIlvneveifslHGKLQTSARTKTLTAF 315
Cdd:cd18789 25 RRLLAAMNPN-KLRALEELLKRHEqGDKIIV-FTDNVEALYRYA--KRLLKPFI----------TGETPQSEREEILQNF 90
|
90 100 110
....*....|....*....|....*....|
gi 14318521 316 TDSLSNsVLFTTDVAARGIDIPDVDLVIQL 345
Cdd:cd18789 91 REGEYN-TLVVSKVGDEGIDLPEANVAIQI 119
|
|
| PRK13767 |
PRK13767 |
ATP-dependent helicase; Provisional |
27-61 |
6.70e-03 |
|
ATP-dependent helicase; Provisional
Pssm-ID: 237497 [Multi-domain] Cd Length: 876 Bit Score: 39.48 E-value: 6.70e-03
10 20 30
....*....|....*....|....*....|....*.
gi 14318521 27 FETMTPVQASTIPMLAGNKDVVVDSVTGSGKT-AAF 61
Cdd:PRK13767 30 FGTFTPPQRYAIPLIHEGKNVLISSPTGSGKTlAAF 65
|
|
| |
