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Conserved domains on  [gi|398364325|ref|NP_116677|]
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Rog3p [Saccharomyces cerevisiae S288C]

Protein Classification

arrestin family protein( domain architecture ID 10432337)

arrestin family protein with both N-terminal and C-terminal Ig-like beta-sandwich domains found in arrestin (S antigen)

CATH:  2.60.40.840
PubMed:  7720881|7833798
SCOP:  4007521

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Arrestin_C smart01017
Arrestin (or S-antigen), C-terminal domain; Ig-like beta-sandwich fold. Scop reports ...
 232-393 5.09e-25

Arrestin (or S-antigen), C-terminal domain; Ig-like beta-sandwich fold. Scop reports duplication with N-terminal domain. Arrestins comprise a family of closely-related proteins that includes beta-arrestin-1 and -2, which regulate the function of beta-adrenergic receptors by binding to their phosphorylated forms, impairing their capacity to activate G(S) proteins; Cone photoreceptors C-arrestin (arrestin-X). which could bind to phosphorylated red/green opsins; and Drosophila phosrestins I and II, which undergo light-induced phosphorylation, and probably play a role in photoreceptor transduction.


:

Pssm-ID: 214976 [Multi-domain]  Cd Length: 142  Bit Score: 101.27  E-value: 5.09e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364325   232 WPDKVDYSISVPNKAVAIGSATPINISIVPLSKGlKLGSIKVVLFENYQYCDPFPPVISENRQVTELNLEDPlNESSGEF 311
Cdd:smart01017   1 WSGPLSLEVSLPKKGYVPGETIPVTIKITNLSKK-TVKKIKVSLVQTVTYVSSDGPVKRSLAEKSKEKKADR-KTLVKEL 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364325   312 NGNGCFVNNpffqpdhsfQDKWEIDtiLQIPnSLSNCVQDCDvrsNIKVRHKLKffiILINPDGHKSELRASLPIQLFIS 391
Cdd:smart01017  79 DGGPVLPGN---------KDKFEGQ--LKVP-PLPPTSRTCR---LIKVEYKLK---VKLRLSGKHSELRLELPITIGTV 140


                   ..
gi 398364325   392 PF 393
Cdd:smart01017 141 PL 142
Arrestin_N super family cl22903
Arrestin (or S-antigen), N-terminal domain; Ig-like beta-sandwich fold. Scop reports ...
 156-215 1.64e-03

Arrestin (or S-antigen), N-terminal domain; Ig-like beta-sandwich fold. Scop reports duplication with C-terminal domain.


The actual alignment was detected with superfamily member pfam00339:

Pssm-ID: 451447  Cd Length: 148  Bit Score: 39.58  E-value: 1.64e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364325  156 TLDKGNYDFPFSAILPGSLPESVESLPnCFVTYSMESVIERSkNYSDLICRKNIRVLRTI 215
Cdd:pfam00339  88 KLPAGTHTFPFSFTLPPNCPSSFEGKH-GGIRYEVKVTLDRP-WKFNKSFRRVFTVIPKL 145
 
Name Accession Description Interval E-value
Arrestin_C smart01017
Arrestin (or S-antigen), C-terminal domain; Ig-like beta-sandwich fold. Scop reports ...
 232-393 5.09e-25

Arrestin (or S-antigen), C-terminal domain; Ig-like beta-sandwich fold. Scop reports duplication with N-terminal domain. Arrestins comprise a family of closely-related proteins that includes beta-arrestin-1 and -2, which regulate the function of beta-adrenergic receptors by binding to their phosphorylated forms, impairing their capacity to activate G(S) proteins; Cone photoreceptors C-arrestin (arrestin-X). which could bind to phosphorylated red/green opsins; and Drosophila phosrestins I and II, which undergo light-induced phosphorylation, and probably play a role in photoreceptor transduction.


Pssm-ID: 214976 [Multi-domain]  Cd Length: 142  Bit Score: 101.27  E-value: 5.09e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364325   232 WPDKVDYSISVPNKAVAIGSATPINISIVPLSKGlKLGSIKVVLFENYQYCDPFPPVISENRQVTELNLEDPlNESSGEF 311
Cdd:smart01017   1 WSGPLSLEVSLPKKGYVPGETIPVTIKITNLSKK-TVKKIKVSLVQTVTYVSSDGPVKRSLAEKSKEKKADR-KTLVKEL 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364325   312 NGNGCFVNNpffqpdhsfQDKWEIDtiLQIPnSLSNCVQDCDvrsNIKVRHKLKffiILINPDGHKSELRASLPIQLFIS 391
Cdd:smart01017  79 DGGPVLPGN---------KDKFEGQ--LKVP-PLPPTSRTCR---LIKVEYKLK---VKLRLSGKHSELRLELPITIGTV 140


                   ..
gi 398364325   392 PF 393
Cdd:smart01017 141 PL 142
Arrestin_C pfam02752
Arrestin (or S-antigen), C-terminal domain; Ig-like beta-sandwich fold. Scop reports ...
 232-393 3.79e-23

Arrestin (or S-antigen), C-terminal domain; Ig-like beta-sandwich fold. Scop reports duplication with N-terminal domain.


Pssm-ID: 460676  Cd Length: 135  Bit Score: 95.47  E-value: 3.79e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364325  232 WPDKVDYSISVPNKAVAIGSATPINISIVPLSKgLKLGSIKVVLFENYQYCDPFPPviSENRQVTELNLEdplnESSGEF 311
Cdd:pfam02752   1 WSGKVSYSVSLPKKGYVPGETIPVTIEIDNQSK-KKIKKIKISLVQQLTYKAKTPL--GESKREERVVAK----EKNPGV 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364325  312 NGNgcfvnnpffqpdhsFQDKWEIDTILQIPNSLSNCVQDCdvrSNIKVRHKLKFfiiLINPDGHKSELRASLPIQLFIS 391
Cdd:pfam02752  74 APG--------------SKDKWEKELQLQIPTDLPPSSTKC---KIIKVEYKLKV---TVDLSGSASELRLELPITIGTS 133


                  ..
gi 398364325  392 PF 393
Cdd:pfam02752 134 PL 135
Arrestin_N pfam00339
Arrestin (or S-antigen), N-terminal domain; Ig-like beta-sandwich fold. Scop reports ...
 156-215 1.64e-03

Arrestin (or S-antigen), N-terminal domain; Ig-like beta-sandwich fold. Scop reports duplication with C-terminal domain.


Pssm-ID: 425619  Cd Length: 148  Bit Score: 39.58  E-value: 1.64e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364325  156 TLDKGNYDFPFSAILPGSLPESVESLPnCFVTYSMESVIERSkNYSDLICRKNIRVLRTI 215
Cdd:pfam00339  88 KLPAGTHTFPFSFTLPPNCPSSFEGKH-GGIRYEVKVTLDRP-WKFNKSFRRVFTVIPKL 145
 
Name Accession Description Interval E-value
Arrestin_C smart01017
Arrestin (or S-antigen), C-terminal domain; Ig-like beta-sandwich fold. Scop reports ...
 232-393 5.09e-25

Arrestin (or S-antigen), C-terminal domain; Ig-like beta-sandwich fold. Scop reports duplication with N-terminal domain. Arrestins comprise a family of closely-related proteins that includes beta-arrestin-1 and -2, which regulate the function of beta-adrenergic receptors by binding to their phosphorylated forms, impairing their capacity to activate G(S) proteins; Cone photoreceptors C-arrestin (arrestin-X). which could bind to phosphorylated red/green opsins; and Drosophila phosrestins I and II, which undergo light-induced phosphorylation, and probably play a role in photoreceptor transduction.


Pssm-ID: 214976 [Multi-domain]  Cd Length: 142  Bit Score: 101.27  E-value: 5.09e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364325   232 WPDKVDYSISVPNKAVAIGSATPINISIVPLSKGlKLGSIKVVLFENYQYCDPFPPVISENRQVTELNLEDPlNESSGEF 311
Cdd:smart01017   1 WSGPLSLEVSLPKKGYVPGETIPVTIKITNLSKK-TVKKIKVSLVQTVTYVSSDGPVKRSLAEKSKEKKADR-KTLVKEL 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364325   312 NGNGCFVNNpffqpdhsfQDKWEIDtiLQIPnSLSNCVQDCDvrsNIKVRHKLKffiILINPDGHKSELRASLPIQLFIS 391
Cdd:smart01017  79 DGGPVLPGN---------KDKFEGQ--LKVP-PLPPTSRTCR---LIKVEYKLK---VKLRLSGKHSELRLELPITIGTV 140


                   ..
gi 398364325   392 PF 393
Cdd:smart01017 141 PL 142
Arrestin_C pfam02752
Arrestin (or S-antigen), C-terminal domain; Ig-like beta-sandwich fold. Scop reports ...
 232-393 3.79e-23

Arrestin (or S-antigen), C-terminal domain; Ig-like beta-sandwich fold. Scop reports duplication with N-terminal domain.


Pssm-ID: 460676  Cd Length: 135  Bit Score: 95.47  E-value: 3.79e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364325  232 WPDKVDYSISVPNKAVAIGSATPINISIVPLSKgLKLGSIKVVLFENYQYCDPFPPviSENRQVTELNLEdplnESSGEF 311
Cdd:pfam02752   1 WSGKVSYSVSLPKKGYVPGETIPVTIEIDNQSK-KKIKKIKISLVQQLTYKAKTPL--GESKREERVVAK----EKNPGV 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364325  312 NGNgcfvnnpffqpdhsFQDKWEIDTILQIPNSLSNCVQDCdvrSNIKVRHKLKFfiiLINPDGHKSELRASLPIQLFIS 391
Cdd:pfam02752  74 APG--------------SKDKWEKELQLQIPTDLPPSSTKC---KIIKVEYKLKV---TVDLSGSASELRLELPITIGTS 133


                  ..
gi 398364325  392 PF 393
Cdd:pfam02752 134 PL 135
Arrestin_N pfam00339
Arrestin (or S-antigen), N-terminal domain; Ig-like beta-sandwich fold. Scop reports ...
 156-215 1.64e-03

Arrestin (or S-antigen), N-terminal domain; Ig-like beta-sandwich fold. Scop reports duplication with C-terminal domain.


Pssm-ID: 425619  Cd Length: 148  Bit Score: 39.58  E-value: 1.64e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364325  156 TLDKGNYDFPFSAILPGSLPESVESLPnCFVTYSMESVIERSkNYSDLICRKNIRVLRTI 215
Cdd:pfam00339  88 KLPAGTHTFPFSFTLPPNCPSSFEGKH-GGIRYEVKVTLDRP-WKFNKSFRRVFTVIPKL 145
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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