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Conserved domains on  [gi|154146260|ref|NP_149443|]
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keratin-associated protein 4-3 [Homo sapiens]

Protein Classification

Keratin_B2 domain-containing protein( domain architecture ID 12021880)

Keratin_B2 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 43-169 4.12e-23

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


:

Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 90.24  E-value: 4.12e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146260   43 SCCISSCCRPSCCISSCCKPSCCRTTCCRPSCCISSCCRPSC---CISSCCKPSCCRTTCCRPSCCISSCCRPSCCISSC 119
Cdd:pfam01500  18 GTCGSGCCQPCCCQSSCCRPSCCQTSCCQPTTFQSSCCRPTCqpcCQTSCCQPTCCQTSSCQTGCGGIGYGQEGSSGAVS 97

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 154146260  120 CKPSCCQTTCCRPSCCISSCYRPQCCQPSCCRPACCISSCCHPSCCVSSC 169
Cdd:pfam01500  98 SRTRWCRPDCRVEGTCLPPCCVVSCTPPTCCQLHHAQASCCRPSYCGQSC 147
 
Name Accession Description Interval E-value
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 43-169 4.12e-23

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 90.24  E-value: 4.12e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146260   43 SCCISSCCRPSCCISSCCKPSCCRTTCCRPSCCISSCCRPSC---CISSCCKPSCCRTTCCRPSCCISSCCRPSCCISSC 119
Cdd:pfam01500  18 GTCGSGCCQPCCCQSSCCRPSCCQTSCCQPTTFQSSCCRPTCqpcCQTSCCQPTCCQTSSCQTGCGGIGYGQEGSSGAVS 97

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 154146260  120 CKPSCCQTTCCRPSCCISSCYRPQCCQPSCCRPACCISSCCHPSCCVSSC 169
Cdd:pfam01500  98 SRTRWCRPDCRVEGTCLPPCCVVSCTPPTCCQLHHAQASCCRPSYCGQSC 147
NosR COG3901
Transcriptional regulator NosR of nitric oxide reductase [Transcription];
69-156 7.45e-07

Transcriptional regulator NosR of nitric oxide reductase [Transcription];


Pssm-ID: 443108 [Multi-domain]  Cd Length: 713  Bit Score: 48.39  E-value: 7.45e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146260  69 CCRPSCCissCCRPSCCISSCCKPSCCRTTCCRPSCCISSCCRPSCCISSCCKPSCCQTTCCRPSCCissCYRpQCCQPS 148
Cdd:COG3901  603 FFFFRRL---CLLGLALAAAALARRRLWRRRRRECCCGCCCCCCKCCCIVIIIDGIIIINECCCCCC---LCC-RRCQDD 675


                 ....*...
gi 154146260 149 CCRPACCI 156
Cdd:COG3901  676 PLCPPRIK 683
 
Name Accession Description Interval E-value
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 43-169 4.12e-23

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 90.24  E-value: 4.12e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146260   43 SCCISSCCRPSCCISSCCKPSCCRTTCCRPSCCISSCCRPSC---CISSCCKPSCCRTTCCRPSCCISSCCRPSCCISSC 119
Cdd:pfam01500  18 GTCGSGCCQPCCCQSSCCRPSCCQTSCCQPTTFQSSCCRPTCqpcCQTSCCQPTCCQTSSCQTGCGGIGYGQEGSSGAVS 97

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 154146260  120 CKPSCCQTTCCRPSCCISSCYRPQCCQPSCCRPACCISSCCHPSCCVSSC 169
Cdd:pfam01500  98 SRTRWCRPDCRVEGTCLPPCCVVSCTPPTCCQLHHAQASCCRPSYCGQSC 147
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 3-154 1.19e-20

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 84.07  E-value: 1.19e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146260    3 SSCCGSVCSDQS-CGQGLGQESCCRPSCCQTTCCRTTCCRPSCCISSCCRPSC---CISSCCKPSCCRTTCCRPSCCISS 78
Cdd:pfam01500   7 SFCGFPTCSTGGtCGSGCCQPCCCQSSCCRPSCCQTSCCQPTTFQSSCCRPTCqpcCQTSCCQPTCCQTSSCQTGCGGIG 86

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 154146260   79 CCRPSCCISSCCKPSCCRTTCCRPSCCISSCCRPSCCISSCCKPSCCQTTCCRPSCCISSCYRPQCCqPSCCRPAC 154
Cdd:pfam01500  87 YGQEGSSGAVSSRTRWCRPDCRVEGTCLPPCCVVSCTPPTCCQLHHAQASCCRPSYCGQSCCRPACC-CQCSEPTC 161
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 46-195 3.84e-20

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 82.53  E-value: 3.84e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146260   46 ISSCCRPSCCISSCCKPSCCRTTCCRPSCCISSCCRPSCCISSCCKPSCCRTTCCRPSCciSSCCRPSCCISSCCKPSCC 125
Cdd:pfam01500   1 MACCGTSFCGFPTCSTGGTCGSGCCQPCCCQSSCCRPSCCQTSCCQPTTFQSSCCRPTC--QPCCQTSCCQPTCCQTSSC 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146260  126 QTTCCRPSCCISSCYRPQCCQPSCCRPACCISSCCHPSCCVSSCRCPFSCPTTCCRTTCFHPICCGSSCC 195
Cdd:pfam01500  79 QTGCGGIGYGQEGSSGAVSSRTRWCRPDCRVEGTCLPPCCVVSCTPPTCCQLHHAQASCCRPSYCGQSCC 148
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
69-113 1.65e-12

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 59.32  E-value: 1.65e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 154146260   69 CCRPSCCISSCCRPSCCISSCCKPSCCRTTCCRPSCCISSCCRPS 113
Cdd:pfam13885   1 CCQPSCCQPSCCQPSCCQPSCCQPSCCQPSCCRPSCCRSSCCQPT 45
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
89-133 2.49e-12

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 58.93  E-value: 2.49e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 154146260   89 CCKPSCCRTTCCRPSCCISSCCRPSCCISSCCKPSCCQTTCCRPS 133
Cdd:pfam13885   1 CCQPSCCQPSCCQPSCCQPSCCQPSCCQPSCCRPSCCRSSCCQPT 45
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
59-103 2.54e-12

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 58.93  E-value: 2.54e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 154146260   59 CCKPSCCRTTCCRPSCCISSCCRPSCCISSCCKPSCCRTTCCRPS 103
Cdd:pfam13885   1 CCQPSCCQPSCCQPSCCQPSCCQPSCCQPSCCRPSCCRSSCCQPT 45
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
49-93 3.64e-12

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 58.55  E-value: 3.64e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 154146260   49 CCRPSCCISSCCKPSCCRTTCCRPSCCISSCCRPSCCISSCCKPS 93
Cdd:pfam13885   1 CCQPSCCQPSCCQPSCCQPSCCQPSCCQPSCCRPSCCRSSCCQPT 45
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
79-123 3.64e-12

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 58.55  E-value: 3.64e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 154146260   79 CCRPSCCISSCCKPSCCRTTCCRPSCCISSCCRPSCCISSCCKPS 123
Cdd:pfam13885   1 CCQPSCCQPSCCQPSCCQPSCCQPSCCQPSCCRPSCCRSSCCQPT 45
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
99-142 4.04e-12

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 58.16  E-value: 4.04e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 154146260   99 CCRPSCCISSCCRPSCCISSCCKPSCCQTTCCRPSCCISSCYRP 142
Cdd:pfam13885   1 CCQPSCCQPSCCQPSCCQPSCCQPSCCQPSCCRPSCCRSSCCQP 44
PMG pfam05287
PMG protein; This family consists of several mouse anagen-specific protein mKAP13 (PMG1 and ...
 1-173 5.82e-12

PMG protein; This family consists of several mouse anagen-specific protein mKAP13 (PMG1 and PMG2). PMG1 and 2 contain characteriztic repeats reminiscent of the keratin-associated proteins (KAPs). Both genes are expressed in growing hair follicles in skin as well as in sebaceous and eccrine sweat glands. Interestingly, expression is also detected in the mammary epithelium where it is limited to the onset of the pubertal growth phase and is independent of ovarian hormones. Their broad, developmentally controlled expression pattern, together with their unique amino acid composition, demonstrate that pmg-1 and pmg-2 constitute a novel KAP gene family participating in the differentiation of all epithelial cells forming the epidermal appendages.


Pssm-ID: 283053 [Multi-domain]  Cd Length: 180  Bit Score: 61.37  E-value: 5.82e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146260    1 MVSSCCGSVCSDQSCGQGLG-QESCCRPSCCQTTCCRTTCCRPSCCISSCCRPSCCISSCCKPSCCRTTCCRPSCCISSC 79
Cdd:pfam05287   1 MSYNCCSGNFSSRSLRNHLHyPVSSCGSSCPSNLSYSTDLCSPSSCQLGSSLRDNCQETCGEPTSCQTSSCEPCTSSTSY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146260   80 CRPSCCISSC------CKPSCCRTTCCRPSCCISSCCRPSCCISSCCKPSCCQTTCCRPSCCISSCYRPQCCQPSCCRPA 153
Cdd:pfam05287  81 CVPSPCQRSCysprtsCVCSPCQTTSAGSLGFGSSSCQSLGYGSNSCQPLGCGSSGFRPLGCLSKGFQSLGYGSSFCRPS 160

                         170       180
                  ....*....|....*....|
gi 154146260  154 CCISSCCHPSCCVSSCRCPF 173
Cdd:pfam05287 161 YVSSRSYQPSCFRPSCGSGF 180
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
94-135 1.01e-11

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 57.39  E-value: 1.01e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 154146260   94 CCRTTCCRPSCCISSCCRPSCCISSCCKPSCCQTTCCRPSCC 135
Cdd:pfam13885   1 CCQPSCCQPSCCQPSCCQPSCCQPSCCQPSCCRPSCCRSSCC 42
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
119-163 1.40e-11

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 57.01  E-value: 1.40e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 154146260  119 CCKPSCCQTTCCRPSCCISSCYRPQCCQPSCCRPACCISSCCHPS 163
Cdd:pfam13885   1 CCQPSCCQPSCCQPSCCQPSCCQPSCCQPSCCRPSCCRSSCCQPT 45
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
84-126 1.44e-11

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 57.01  E-value: 1.44e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 154146260   84 CCISSCCKPSCCRTTCCRPSCCISSCCRPSCCISSCCKPSCCQ 126
Cdd:pfam13885   1 CCQPSCCQPSCCQPSCCQPSCCQPSCCQPSCCRPSCCRSSCCQ 43
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
109-153 1.86e-11

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 56.62  E-value: 1.86e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 154146260  109 CCRPSCCISSCCKPSCCQTTCCRPSCCISSCYRPQCCQPSCCRPA 153
Cdd:pfam13885   1 CCQPSCCQPSCCQPSCCQPSCCQPSCCQPSCCRPSCCRSSCCQPT 45
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
124-165 9.43e-11

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 54.70  E-value: 9.43e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 154146260  124 CCQTTCCRPSCCISSCYRPQCCQPSCCRPACCISSCCHPSCC 165
Cdd:pfam13885   1 CCQPSCCQPSCCQPSCCQPSCCQPSCCQPSCCRPSCCRSSCC 42
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
42-83 1.09e-10

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 54.70  E-value: 1.09e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 154146260   42 PSCCISSCCRPSCCISSCCKPSCCRTTCCRPSCCISSCCRPS 83
Cdd:pfam13885   4 PSCCQPSCCQPSCCQPSCCQPSCCQPSCCRPSCCRSSCCQPT 45
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
129-172 1.55e-09

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 51.61  E-value: 1.55e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 154146260  129 CCRPSCCISSCYRPQCCQPSCCRPACCISSCCHPSCCVSSCRCP 172
Cdd:pfam13885   1 CCQPSCCQPSCCQPSCCQPSCCQPSCCQPSCCRPSCCRSSCCQP 44
PMG pfam05287
PMG protein; This family consists of several mouse anagen-specific protein mKAP13 (PMG1 and ...
 23-195 5.62e-07

PMG protein; This family consists of several mouse anagen-specific protein mKAP13 (PMG1 and PMG2). PMG1 and 2 contain characteriztic repeats reminiscent of the keratin-associated proteins (KAPs). Both genes are expressed in growing hair follicles in skin as well as in sebaceous and eccrine sweat glands. Interestingly, expression is also detected in the mammary epithelium where it is limited to the onset of the pubertal growth phase and is independent of ovarian hormones. Their broad, developmentally controlled expression pattern, together with their unique amino acid composition, demonstrate that pmg-1 and pmg-2 constitute a novel KAP gene family participating in the differentiation of all epithelial cells forming the epidermal appendages.


Pssm-ID: 283053 [Multi-domain]  Cd Length: 180  Bit Score: 47.50  E-value: 5.62e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146260   23 SCCRPSCCQTTCCRTTCCRPSCCISSCCRPSCCISSCCKPSCCRTTCCRPSCCISSCCRPSCCISSCCKPSCCRTTCCRP 102
Cdd:pfam05287   4 NCCSGNFSSRSLRNHLHYPVSSCGSSCPSNLSYSTDLCSPSSCQLGSSLRDNCQETCGEPTSCQTSSCEPCTSSTSYCVP 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146260  103 SCCISSCCRPSccisSCCKPSCCQTTCCRPSCCISSCYRPQCCQPSCCRPACCISSCCHPSCCVSSCRCPFSCPTTCCRT 182
Cdd:pfam05287  84 SPCQRSCYSPR----TSCVCSPCQTTSAGSLGFGSSSCQSLGYGSNSCQPLGCGSSGFRPLGCLSKGFQSLGYGSSFCRP 159

                         170
                  ....*....|...
gi 154146260  183 TCFHPICCGSSCC 195
Cdd:pfam05287 160 SYVSSRSYQPSCF 172
NosR COG3901
Transcriptional regulator NosR of nitric oxide reductase [Transcription];
69-156 7.45e-07

Transcriptional regulator NosR of nitric oxide reductase [Transcription];


Pssm-ID: 443108 [Multi-domain]  Cd Length: 713  Bit Score: 48.39  E-value: 7.45e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146260  69 CCRPSCCissCCRPSCCISSCCKPSCCRTTCCRPSCCISSCCRPSCCISSCCKPSCCQTTCCRPSCCissCYRpQCCQPS 148
Cdd:COG3901  603 FFFFRRL---CLLGLALAAAALARRRLWRRRRRECCCGCCCCCCKCCCIVIIIDGIIIINECCCCCC---LCC-RRCQDD 675


                 ....*...
gi 154146260 149 CCRPACCI 156
Cdd:COG3901  676 PLCPPRIK 683
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
21-73 3.58e-06

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 42.37  E-value: 3.58e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 154146260   21 QESCCRPSCCQttccrttccrPSCCISSCCRPSCCISSCCKPSCCRTTCCRPS 73
Cdd:pfam13885   3 QPSCCQPSCCQ----------PSCCQPSCCQPSCCQPSCCRPSCCRSSCCQPT 45
NosR COG3901
Transcriptional regulator NosR of nitric oxide reductase [Transcription];
49-132 1.08e-05

Transcriptional regulator NosR of nitric oxide reductase [Transcription];


Pssm-ID: 443108 [Multi-domain]  Cd Length: 713  Bit Score: 44.93  E-value: 1.08e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146260  49 CCRPSCCISSCCKPSCCRTTCCRPSCCISSCCRPSCCISSCCKPSCCRTTCCRPSCCIssCCRpsccissCCKPSCCQTT 128
Cdd:COG3901  610 CLLGLALAAAALARRRLWRRRRRECCCGCCCCCCKCCCIVIIIDGIIIINECCCCCCL--CCR-------RCQDDPLCPP 680


                 ....
gi 154146260 129 CCRP 132
Cdd:COG3901  681 RIKK 684
NosR COG3901
Transcriptional regulator NosR of nitric oxide reductase [Transcription];
64-135 1.25e-05

Transcriptional regulator NosR of nitric oxide reductase [Transcription];


Pssm-ID: 443108 [Multi-domain]  Cd Length: 713  Bit Score: 44.93  E-value: 1.25e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 154146260  64 CCRTTCCRPSC-CISSCCRPSCCISSCCKPSCCRTTCCRPSCCISSCCRPSCCISSCCKPSCCQTTCCRPSCC 135
Cdd:COG3901  605 FFRRLCLLGLAlAAAALARRRLWRRRRRECCCGCCCCCCKCCCIVIIIDGIIIINECCCCCCLCCRRCQDDPL 677
NosR COG3901
Transcriptional regulator NosR of nitric oxide reductase [Transcription];
82-171 2.66e-05

Transcriptional regulator NosR of nitric oxide reductase [Transcription];


Pssm-ID: 443108 [Multi-domain]  Cd Length: 713  Bit Score: 43.77  E-value: 2.66e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146260  82 PSCCISSCCKPSCCRTTCCRPSCCISSCCRPSCCISSCCKPSCCQTTCCRPSCCisscyrpqCCQPSCCRPACCISSCCH 161
Cdd:COG3901  591 VFLLLLLLLLLFFFFFRRLCLLGLALAAAALARRRLWRRRRRECCCGCCCCCCK--------CCCIVIIIDGIIIINECC 662

                         90
                 ....*....|
gi 154146260 162 PSCCvssCRC 171
Cdd:COG3901  663 CCCC---LCC 669
NosR COG3901
Transcriptional regulator NosR of nitric oxide reductase [Transcription];
54-151 5.24e-05

Transcriptional regulator NosR of nitric oxide reductase [Transcription];


Pssm-ID: 443108 [Multi-domain]  Cd Length: 713  Bit Score: 43.00  E-value: 5.24e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146260  54 CCISSCCKPSCCRTTCCRPSCCISSCCRPSCCISSCCKPSCCRTTCCRpsCCIssCCRPSCCISSCCKPSCCQTTCCrps 133
Cdd:COG3901  594 LLLLLLLLFFFFFRRLCLLGLALAAAALARRRLWRRRRRECCCGCCCC--CCK--CCCIVIIIDGIIIINECCCCCC--- 666

                         90
                 ....*....|....*...
gi 154146260 134 CCISSCYRPQCCQPSCCR 151
Cdd:COG3901  667 LCCRRCQDDPLCPPRIKK 684
PMG pfam05287
PMG protein; This family consists of several mouse anagen-specific protein mKAP13 (PMG1 and ...
 51-195 5.79e-05

PMG protein; This family consists of several mouse anagen-specific protein mKAP13 (PMG1 and PMG2). PMG1 and 2 contain characteriztic repeats reminiscent of the keratin-associated proteins (KAPs). Both genes are expressed in growing hair follicles in skin as well as in sebaceous and eccrine sweat glands. Interestingly, expression is also detected in the mammary epithelium where it is limited to the onset of the pubertal growth phase and is independent of ovarian hormones. Their broad, developmentally controlled expression pattern, together with their unique amino acid composition, demonstrate that pmg-1 and pmg-2 constitute a novel KAP gene family participating in the differentiation of all epithelial cells forming the epidermal appendages.


Pssm-ID: 283053 [Multi-domain]  Cd Length: 180  Bit Score: 41.73  E-value: 5.79e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146260   51 RPSCCISSCCKPSCCRTTCCRP-SCCISSCCRPSCCISSCCKPSCCRTTCCRPSCCISSCCRPSCCISSCCKPSCCQTTC 129
Cdd:pfam05287   1 MSYNCCSGNFSSRSLRNHLHYPvSSCGSSCPSNLSYSTDLCSPSSCQLGSSLRDNCQETCGEPTSCQTSSCEPCTSSTSY 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 154146260  130 CRPSCCISSCYRP------QCCQPSCCRPACCISSCCHPSCCVSScrcpfSCPTTCCRTTCFHPICCGSSCC 195
Cdd:pfam05287  81 CVPSPCQRSCYSPrtscvcSPCQTTSAGSLGFGSSSCQSLGYGSN-----SCQPLGCGSSGFRPLGCLSKGF 147
NosR COG3901
Transcriptional regulator NosR of nitric oxide reductase [Transcription];
74-166 1.24e-04

Transcriptional regulator NosR of nitric oxide reductase [Transcription];


Pssm-ID: 443108 [Multi-domain]  Cd Length: 713  Bit Score: 41.84  E-value: 1.24e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146260  74 CCISSCCRPSCCISSCCKPSCCRTtCCRPSCCISSCCRPSCCISSCCkpsCCQTTCCRPSCCISSCYRPQCCQPSCCRPA 153
Cdd:COG3901  594 LLLLLLLLFFFFFRRLCLLGLALA-AAALARRRLWRRRRRECCCGCC---CCCCKCCCIVIIIDGIIIINECCCCCCLCC 669

                         90
                 ....*....|...
gi 154146260 154 CCISSCCHPSCCV 166
Cdd:COG3901  670 RRCQDDPLCPPRI 682
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
144-195 2.65e-04

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 37.36  E-value: 2.65e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 154146260  144 CCQPSCCRPACCISSCCHPSCCVSSCRCPFSCpttccrttcfHPICCGSSCC 195
Cdd:pfam13885   1 CCQPSCCQPSCCQPSCCQPSCCQPSCCQPSCC----------RPSCCRSSCC 42
Nar1 COG4624
Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion];
44-139 1.15e-03

Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion];


Pssm-ID: 443663 [Multi-domain]  Cd Length: 450  Bit Score: 38.85  E-value: 1.15e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146260  44 CCISSCCRPSCCISSCCKPSCCRTTCCRPSCCISSCCRPSCCISSCCKPSCCRTTCCRPSCCISSCCRPSCCISSCCKPS 123
Cdd:COG4624    8 CCCCCIEEGDELLLLEEAERVLRIIILEALLPEHVDDDSACSCCPRCCLCCCCCCRCCVAISCIQVRGIIIIDKRGPSII 87

                         90
                 ....*....|....*.
gi 154146260 124 CCQTTCCRPSCCISSC 139
Cdd:COG4624   88 RDKEKCKNCYPCVRAC 103
Nar1 COG4624
Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion];
59-159 1.90e-03

Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion];


Pssm-ID: 443663 [Multi-domain]  Cd Length: 450  Bit Score: 38.08  E-value: 1.90e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146260  59 CCKPSCCRTTCCRPSCCISSCCRPSCCISSCCKPSCCRTTCCRPSCCISSCCRPSCCISSCCKPSCCQTTCCRPSCCISS 138
Cdd:COG4624    3 LLLRACCCCCIEEGDELLLLEEAERVLRIIILEALLPEHVDDDSACSCCPRCCLCCCCCCRCCVAISCIQVRGIIIIDKR 82

                         90       100
                 ....*....|....*....|.
gi 154146260 139 CYRPQCCQPSCCRPACCISSC 159
Cdd:COG4624   83 GPSIIRDKEKCKNCYPCVRAC 103
Nar1 COG4624
Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion];
74-171 9.23e-03

Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion];


Pssm-ID: 443663 [Multi-domain]  Cd Length: 450  Bit Score: 36.16  E-value: 9.23e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146260  74 CCISSCCRPSCCISSCCKPSCCRTTCCRPSCCISSCCRPSCCISSCCKPSCCQTTCCRPSCCISSCYRPQCCQPSCCRPA 153
Cdd:COG4624    2 LLLLRACCCCCIEEGDELLLLEEAERVLRIIILEALLPEHVDDDSACSCCPRCCLCCCCCCRCCVAISCIQVRGIIIIDK 81

                         90
                 ....*....|....*...
gi 154146260 154 CCISSCCHPSCCVSSCRC 171
Cdd:COG4624   82 RGPSIIRDKEKCKNCYPC 99
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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