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Conserved domains on  [gi|16118229|ref|NP_149461|]
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keratin-associated protein 9-4 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Keratin_B2 super family cl37504
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 31-153 1.04e-16

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


The actual alignment was detected with superfamily member pfam01500:

Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 72.52  E-value: 1.04e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16118229    31 TCSSTPCCQPSCCVSSCCQPCCRPTCCQNTCCQPTCVTSCCQPSCCSTPCCQPTCCGSSCDQSSSCAPV-----YCRRTC 105
Cdd:pfam01500  28 CCCQSSCCRPSCCQTSCCQPTTFQSSCCRPTCQPCCQTSCCQPTCCQTSSCQTGCGGIGYGQEGSSGAVssrtrWCRPDC 107

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 16118229   106 YYPTTVCLPGCLNQSCGSNCCQ------PCCRPACCETTCFQPTCVSSCCQPFC 153
Cdd:pfam01500 108 RVEGTCLPPCCVVSCTPPTCCQlhhaqaSCCRPSYCGQSCCRPACCCQCSEPTC 161
 
Name Accession Description Interval E-value
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 31-153 1.04e-16

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 72.52  E-value: 1.04e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16118229    31 TCSSTPCCQPSCCVSSCCQPCCRPTCCQNTCCQPTCVTSCCQPSCCSTPCCQPTCCGSSCDQSSSCAPV-----YCRRTC 105
Cdd:pfam01500  28 CCCQSSCCRPSCCQTSCCQPTTFQSSCCRPTCQPCCQTSCCQPTCCQTSSCQTGCGGIGYGQEGSSGAVssrtrWCRPDC 107

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 16118229   106 YYPTTVCLPGCLNQSCGSNCCQ------PCCRPACCETTCFQPTCVSSCCQPFC 153
Cdd:pfam01500 108 RVEGTCLPPCCVVSCTPPTCCQlhhaqaSCCRPSYCGQSCCRPACCCQCSEPTC 161
NosR COG3901
Transcriptional regulator NosR of nitric oxide reductase [Transcription];
32-86 3.37e-04

Transcriptional regulator NosR of nitric oxide reductase [Transcription];


Pssm-ID: 443108 [Multi-domain]  Cd Length: 713  Bit Score: 39.53  E-value: 3.37e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*
gi 16118229  32 CSSTPCCQPSCCvssCCQPCCRPTCCQNTCCQPTCvtsCCQPSCCSTPCCQPTCC 86
Cdd:COG3901 634 CCCGCCCCCCKC---CCIVIIIDGIIIINECCCCC---CLCCRRCQDDPLCPPRI 682
 
Name Accession Description Interval E-value
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 31-153 1.04e-16

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 72.52  E-value: 1.04e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16118229    31 TCSSTPCCQPSCCVSSCCQPCCRPTCCQNTCCQPTCVTSCCQPSCCSTPCCQPTCCGSSCDQSSSCAPV-----YCRRTC 105
Cdd:pfam01500  28 CCCQSSCCRPSCCQTSCCQPTTFQSSCCRPTCQPCCQTSCCQPTCCQTSSCQTGCGGIGYGQEGSSGAVssrtrWCRPDC 107

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 16118229   106 YYPTTVCLPGCLNQSCGSNCCQ------PCCRPACCETTCFQPTCVSSCCQPFC 153
Cdd:pfam01500 108 RVEGTCLPPCCVVSCTPPTCCQlhhaqaSCCRPSYCGQSCCRPACCCQCSEPTC 161
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
37-84 5.97e-10

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 51.61  E-value: 5.97e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 16118229    37 CCQPSCCVSSCCQP-CCRPTCCQNTCCQPtcvtSCCQPSCCSTPCCQPT 84
Cdd:pfam13885   1 CCQPSCCQPSCCQPsCCQPSCCQPSCCQP----SCCRPSCCRSSCCQPT 45
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
51-99 2.70e-09

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 50.07  E-value: 2.70e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 16118229    51 CCRPTCCQNTCCQPtcvtSCCQPSCCSTPCCQPTCCGSSCDQSSSCAPV 99
Cdd:pfam13885   1 CCQPSCCQPSCCQP----SCCQPSCCQPSCCQPSCCRPSCCRSSCCQPT 45
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
66-109 2.50e-08

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 47.38  E-value: 2.50e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 16118229    66 CVTSCCQPSCCSTPCCQPTCCGSSCDQSSSCAPVYCRRTCYYPT 109
Cdd:pfam13885   2 CQPSCCQPSCCQPSCCQPSCCQPSCCQPSCCRPSCCRSSCCQPT 45
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
32-74 2.63e-08

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 47.38  E-value: 2.63e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 16118229    32 CSSTPCCQPSCCVSSCCQP-CCRPTCCQNTCCQPTC-VTSCCQPS 74
Cdd:pfam13885   1 CCQPSCCQPSCCQPSCCQPsCCQPSCCQPSCCRPSCcRSSCCQPT 45
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
30-70 1.83e-06

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 42.37  E-value: 1.83e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 16118229    30 TTCSSTPCCQPSCCVSSCCQP-CCRPTCCQNTCCQPTCVTSC 70
Cdd:pfam13885   4 PSCCQPSCCQPSCCQPSCCQPsCCQPSCCRPSCCRSSCCQPT 45
PMG pfam05287
PMG protein; This family consists of several mouse anagen-specific protein mKAP13 (PMG1 and ...
 32-149 7.29e-05

PMG protein; This family consists of several mouse anagen-specific protein mKAP13 (PMG1 and PMG2). PMG1 and 2 contain characteriztic repeats reminiscent of the keratin-associated proteins (KAPs). Both genes are expressed in growing hair follicles in skin as well as in sebaceous and eccrine sweat glands. Interestingly, expression is also detected in the mammary epithelium where it is limited to the onset of the pubertal growth phase and is independent of ovarian hormones. Their broad, developmentally controlled expression pattern, together with their unique amino acid composition, demonstrate that pmg-1 and pmg-2 constitute a novel KAP gene family participating in the differentiation of all epithelial cells forming the epidermal appendages.


Pssm-ID: 283053 [Multi-domain]  Cd Length: 180  Bit Score: 40.96  E-value: 7.29e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16118229    32 CSSTPCCQPSCCVSSCCQPCCRPTCCQNTCCQP-TCVTSCCQPSCCSTPC-----------CQPTCCGSSCDQSSSCAPV 99
Cdd:pfam05287  41 CSPSSCQLGSSLRDNCQETCGEPTSCQTSSCEPcTSSTSYCVPSPCQRSCysprtscvcspCQTTSAGSLGFGSSSCQSL 120

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 16118229   100 YCRRTCYYPTTVCLPGCLNQSCGSNCCQPC------CRPACCETTCFQPTCVSSCC 149
Cdd:pfam05287 121 GYGSNSCQPLGCGSSGFRPLGCLSKGFQSLgygssfCRPSYVSSRSYQPSCFRPSC 176
NosR COG3901
Transcriptional regulator NosR of nitric oxide reductase [Transcription];
32-86 3.37e-04

Transcriptional regulator NosR of nitric oxide reductase [Transcription];


Pssm-ID: 443108 [Multi-domain]  Cd Length: 713  Bit Score: 39.53  E-value: 3.37e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*
gi 16118229  32 CSSTPCCQPSCCvssCCQPCCRPTCCQNTCCQPTCvtsCCQPSCCSTPCCQPTCC 86
Cdd:COG3901 634 CCCGCCCCCCKC---CCIVIIIDGIIIINECCCCC---CLCCRRCQDDPLCPPRI 682
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
4-65 4.08e-04

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 36.21  E-value: 4.08e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 16118229     4 CCSPCCQPTCCrttccrttcwkpttvttcsSTPCCQPSCCVSSCCQP-CCRPTCCQNTCCQPT 65
Cdd:pfam13885   2 CQPSCCQPSCC-------------------QPSCCQPSCCQPSCCQPsCCRPSCCRSSCCQPT 45
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
70-143 4.76e-04

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 36.21  E-value: 4.76e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 16118229    70 CCQPSCCSTPCCQPTCCGSSCDQSSSCAPVycrrtcyypttvclpgclnqscgsnccqpCCRPACCETTCFQPT 143
Cdd:pfam13885   1 CCQPSCCQPSCCQPSCCQPSCCQPSCCQPS-----------------------------CCRPSCCRSSCCQPT 45
NosR COG3901
Transcriptional regulator NosR of nitric oxide reductase [Transcription];
36-103 1.23e-03

Transcriptional regulator NosR of nitric oxide reductase [Transcription];


Pssm-ID: 443108 [Multi-domain]  Cd Length: 713  Bit Score: 37.99  E-value: 1.23e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 16118229  36 PCCQPSCCVSSCCQPCCRPTCCQNTCCQPTCVTSCCQPSCCSTPCCQPTCCgssCDQSSSCAPVYCRR 103
Cdd:COG3901 620 ALARRRLWRRRRRECCCGCCCCCCKCCCIVIIIDGIIIINECCCCCCLCCR---RCQDDPLCPPRIKK 684
NosR COG3901
Transcriptional regulator NosR of nitric oxide reductase [Transcription];
97-154 4.92e-03

Transcriptional regulator NosR of nitric oxide reductase [Transcription];


Pssm-ID: 443108 [Multi-domain]  Cd Length: 713  Bit Score: 36.45  E-value: 4.92e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16118229  97 APVYCRRTCYYPttvCLPGCLNQS------------CGSNCCQPCCRPACCETTCFQPTCVSSCCQPFCC 154
Cdd:COG3901 599 LLLFFFFFRRLC---LLGLALAAAalarrrlwrrrrRECCCGCCCCCCKCCCIVIIIDGIIIINECCCCC 665
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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