|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_PhT |
cd17364 |
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This ... |
22-496 |
1.17e-169 |
|
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of predominantly fungal and plant high-affinity inorganic phosphate transporters (PhT or PiPT), which are involved in the uptake, translocation, and internal transport of inorganic phosphate. They also function in sensing external phosphate levels as transceptors. Phosphate is crucial for structural and metabolic needs, including nucleotide and lipid synthesis, signalling and chemical energy storage. The Pht subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340922 [Multi-domain] Cd Length: 389 Bit Score: 485.24 E-value: 1.17e-169
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 22 IIVAGMGLFTDAYDLFCIAPVMKMISHVYY-NGDSINTAVLSTSYAIALLGTATGQLVFGYLGDRVGRRRVYGLCLIIMI 100
Cdd:cd17364 1 IIIAGMGFFTDAYDLFSISLVTKILGRLYYgGKGSLPSGVSGLVNAAALVGTIIGQLFFGFLGDRFGRKRVYGVELIIMI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 101 LSSFGCGFSVCTTRRsCVMVSLGFFRFFLGLGIGGDYPLSATIMSEFANKRTRGAFIAAVFSMQGLGILVSSAVTMAVCV 180
Cdd:cd17364 81 IGTILSALSPGSTPL-GVMGWLIFFRFLLGIGIGGDYPLSATIMSEYANKKRRGALIAAVFAMQGFGILAGAIVTLILSA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 181 AFKRSGGglevdAAAPTEADLAWRLILMIGALPAALTFYWRmlmpetarytalvennivqaakdmqrvmsrshisdeatt 260
Cdd:cd17364 160 IFEHPLP-----AGTYHHADLVWRIVLGLGAIPALSVLYFR--------------------------------------- 195
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 261 dppppppppsyklfsrcffrlhgRDLFAASFNWFLVDIVFYTSNLLLSHIFSHYSkkPSTAENVYDAAFEVAELGAIIAA 340
Cdd:cd17364 196 -----------------------KHLLGTAGTWFLLDIAFYGQNLFQSTIISAIG--FSKTMNAYQELFNIAVGQLIIAL 250
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 341 CSTIPGYWFTVYFIDKIGRVKIQIMGFFFMAVIYLVAGIPYSWYwskhEHNNKGFMVLYGLVFFFCNFGPNTTTFIIPAE 420
Cdd:cd17364 251 AGTVPGYWFTVFLIDRIGRKKIQMMGFFGMTIFLLILAGPYDHW----KISTIGFFVLYGLTFFFSNFGPNTTTFIVPAE 326
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15218057 421 HFPARFRSTCHGISGAAGKLGAIVGTVGFLWATKKmesddknqiypevNRMRIAFLILGGVCIAGILVTYFFTKET 496
Cdd:cd17364 327 VFPARVRSTCHGISAASGKIGAIVGSFLFLSLTQN-------------IGVRNVLIILAGVALLGIILTLLFPEEK 389
|
|
| 2A0109 |
TIGR00887 |
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the ... |
5-503 |
5.78e-162 |
|
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the major facilitator superfamily (pfam00083). [Transport and binding proteins, Anions]
Pssm-ID: 129965 [Multi-domain] Cd Length: 502 Bit Score: 469.98 E-value: 5.78e-162
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 5 VLSSLDVARTQWYHFKAIIVAGMGLFTDAYDLFCIAPVMKMISHVYYNGD-SINTAVLSTSYAIALLGTATGQLVFGYLG 83
Cdd:TIGR00887 1 ALEEADTAPFGWQHFRAIVIAGVGFFTDSYDLFCISLVTKMLGYVYYHGKgPLPSSVSAAVNGSASIGTLAGQLFFGWLA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 84 DRVGRRRVYGLCLIIMILSSFGCGFSVCTTRRScVMVSLGFFRFFLGLGIGGDYPLSATIMSEFANKRTRGAFIAAVFSM 163
Cdd:TIGR00887 81 DKLGRKRVYGMELIIMIIATVASGLSPGSSPKS-VMATLCFWRFWLGVGIGGDYPLSAIITSEFATKKWRGAMMAAVFAM 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 164 QGLGILVSSAVTMAVCVAFK----RSGGGLEVDAAAPTEADLAWRLILMIGALPAALTFYWRMLMPETARYTALVENNIV 239
Cdd:TIGR00887 160 QGFGILAGAIVALIVLAGFKhsleAAADEASCTGSCVPAVDYMWRILIGFGAVPALLALYFRLTIPETPRYTADVAKDVE 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 240 QAAKDMQRVMSRSHISD----EATTDPPPPPPPPSYKLFSRCFFRLHGRDLFAASFNWFLVDIVFYTSNLLLSHIFSH-- 313
Cdd:TIGR00887 240 QAASDMSAVLQVKIEAEpdevEKASTAVEVPKASWSDFFTHFFKWRHGKHLLGTAGSWFLLDIAFYGVNLNQKVILSAig 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 314 YSKkPSTAENVYDAAFEVAELGAIIAACSTIPGYWFTVYFIDKIGRVKIQIMGFFFMAVIYLVAGIPYSwYWSKHehnnk 393
Cdd:TIGR00887 320 YSP-PAATNNAYEELYKTAVGNLIIALAGTVPGYWVTVFLVDIIGRKPIQLMGFFILTVLFFVLGFAYN-HLSTH----- 392
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 394 GFMVLYGLVFFFCNFGPNTTTFIIPAEHFPARFRSTCHGISGAAGKLGAIVGTVGFLWATkkmESDDKNQIYPEVNRMRI 473
Cdd:TIGR00887 393 GFLAIYVLAQFFANFGPNATTFIVPGEVFPTRYRSTAHGISAASGKAGAIIGQFGFLYLA---QHGDPTKGYPTGIWMGH 469
|
490 500 510
....*....|....*....|....*....|
gi 15218057 474 AFLILGGVCIAGILVTyFFTKETMGRSLEE 503
Cdd:TIGR00887 470 VLEIFALFMFLGILFT-LLIPETKGKSLEE 498
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
22-447 |
1.48e-41 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 152.76 E-value: 1.48e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 22 IIVAGMGLFTDAYDLFCIAPVMKMISHVYynGDSINTAVLSTSYAIALLGTATGQLVFGYLGDRVGRRRVYGLCLIIMIL 101
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEF--SLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 102 SSFGCGFSVcttrrscVMVSLGFFRFFLGLGIGGDYPLSATIMSEFANKRTRGAFIAAVFSMQGLGILVSSAVTMAVcva 181
Cdd:cd17316 79 ATLLIGLLP-------TPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLL--- 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 182 fkrsggglevdaAAPTEADLAWRLILMIGALPAALTFYWRmlmpetarytalvennivqaakdmqrvmsrshisdeattd 261
Cdd:cd17316 149 ------------IPLLSGDWGWRILFLIGALPALLALLLR---------------------------------------- 176
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 262 ppppppppsyklfsrcffrlhgRDLFAASFNWFLVDIVFYTSNLLLshifshyskkPSTAENVYDAAFEVAELGAIIAAC 341
Cdd:cd17316 177 ----------------------RRTLLLILLWFFISFGYYGLTTFL----------PTYLQTVLGLSPATSSLYLLLISL 224
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 342 STIPGYWFTVYFIDKIGRvKIQIMGFFFMAVIylvAGIPYSWYWSkhehNNKGFMVLYGLVFFFCNFGPNTTTFIIPAEH 421
Cdd:cd17316 225 GALVGALIAGLLSDRIGR-KKTLVIGLILSGI---LALPLFYLLS----GSPTLLLLLLFILSFFVGGVWGALYAYLAEL 296
|
410 420
....*....|....*....|....*.
gi 15218057 422 FPARFRSTCHGISGAAGKLGAIVGTV 447
Cdd:cd17316 297 FPTEVRATGVGLSYNLGRLGGGGAPP 322
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
23-503 |
4.55e-40 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 150.89 E-value: 4.55e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 23 IVAGMGLFTDAYDLFCIAPVMKMISHVYYNGDSINTAVLSTSY-------AIALLGTATGQLVFGYLGDRVGRRRVYGLC 95
Cdd:pfam00083 3 LVAALGGFLFGYDTGVIGAFLTLIDFFKNFGLSKSVSSLAALSvlsglivSIFSVGCFIGSLFAGKLGDRFGRKKSLLIA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 96 LIIMILSSFGCGFsvCTTRRSCVMVSLGffRFFLGLGIGGDYPLSATIMSEFANKRTRGAFIAAVFSMQGLGILVSSAVT 175
Cdd:pfam00083 83 NVLFVIGAVLQGA--AKGKWSVYQLIVG--RVLVGIGVGGASVLAPMYISEIAPKKLRGALGSLYQLAITFGILLAYIFG 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 176 mavcVAFKRSGgglevdaaapteADLAWRLILMIGALPAALTFYWRMLMPETARYTALVeNNIVQAAKDMQRVMSRSHIS 255
Cdd:pfam00083 159 ----LGLNKTS------------NSDGWRIPLGLQLVPALLLIIGLLFLPESPRWLVEK-GRLEEAREVLAKLRGVPDVD 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 256 DEATTDPPPPPPPPS-YKLFSRCFFRLHGRdlfaasfNWFLVDIVFYTSNLLLSHIFSHYSKKPSTAENV-YDAAFEVAE 333
Cdd:pfam00083 222 RELDEIKDSLEAGQEaEKASWKELFSTKTR-------RQRLLIGVMLQIFQQLTGINAIFYYSTTIFENLgLSDSFLVTI 294
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 334 LGAIIAACSTIPGywftVYFIDKIGRVKIQIMGFFFMAVIYLVAGIPYSWYWSKHEHNNKGFMVLYGLVFFFCNFGPNTT 413
Cdd:pfam00083 295 IVGVVNFVFTFIA----IFLVDRFGRRPLLLLGAAGMAICFVILGIVALLGVSKSDWAGIVAIVFIALFIAFFAMGWGPV 370
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 414 TFIIPAEHFPARFRSTCHGISGAAGKLGAIVGTVGFLWATKKMESddknqiypevnrmRIAFLILGGVCIAGILVTYFFT 493
Cdd:pfam00083 371 PWVIVSELFPLSVRSKAMALATAANWLANFLIGFLFPIITDAIGL-------------GYTFFIFAGLLVLFIIFVFFFV 437
|
490
....*....|
gi 15218057 494 KETMGRSLEE 503
Cdd:pfam00083 438 PETKGRTLEE 447
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
12-234 |
4.79e-29 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 116.45 E-value: 4.79e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 12 ARTQWYHFKAIIVAGMGLFTDAYDLFCIAPVMKMISHVYyngdSINTAVLSTSYAIALLGTATGQLVFGYLGDRVGRRRV 91
Cdd:COG0477 6 AAPTRRRRRALLALALGTFLEGLDFTIVNVALPSIAADL----GASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 92 YGLCLIIMILSSFGCGFSVcttrrscVMVSLGFFRFFLGLGIGGDYPLSATIMSEFANKRTRGAFIAAVFSMQGLGILVS 171
Cdd:COG0477 82 LLIGLLLFGLASLLCGLAP-------SPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALG 154
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15218057 172 SAVtmavcvafkrsgGGLEVDAaapteadLAWRLILMIGALPAALTFYWRMLMPETARYTALV 234
Cdd:COG0477 155 PLL------------GGLLVAA-------LGWRWIFLINAPLGLLALVLRLRLPESRGLLLAL 198
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
12-442 |
4.94e-25 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 106.21 E-value: 4.94e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 12 ARTQWYHFKAIIVAGMGLFTDAYDLFCIAPVMKMISHVYyngdSINTAVLSTSYAIALLGTATGQLVFGYLGDRVGRRRV 91
Cdd:COG2814 2 PATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADL----GASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRV 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 92 YGLCLIIMILSSFGCGFSVcttrrscVMVSLGFFRFFLGLGIGGDYPLSATIMSEFANKRTRGAFIAAVFSMQGLGILVS 171
Cdd:COG2814 78 LLLGLLLFALGSLLCALAP-------SLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALG 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 172 SAVtmavcvafkrsgGGLEVDAaapteadLAWRLILMIGALPAALTFYW-RMLMPETARYTAlvenniVQAAKDMQRVMS 250
Cdd:COG2814 151 PLL------------GGLLADL-------FGWRWVFLVNAVLALLALLLlLRLLPESRPAAR------ARLRGSLRELLR 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 251 RshisdeattdppppppppsyklfsrcffrlhgRDLFAASFNWFLVDIVFYTSNLLLshifshyskkPSTAENVYDAAFE 330
Cdd:COG2814 206 R--------------------------------PRLLLLLLLAFLLGFGFFALFTYL----------PLYLQEVLGLSAS 243
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 331 VAELGAIIAACSTIPGYWFTVYFIDKIGRVKIQIMGFFFMAVIYLVAGIPYSWYWskhehnnkgfMVLYGLVFFFCNFGP 410
Cdd:COG2814 244 AAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWL----------LLLALFLLGFGFGLL 313
|
410 420 430
....*....|....*....|....*....|..
gi 15218057 411 NTTTFIIPAEHFPARFRSTCHGISGAAGKLGA 442
Cdd:COG2814 314 FPLLQALVAELAPPEARGRASGLYNSAFFLGG 345
|
|
| SP |
TIGR00879 |
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ... |
14-504 |
1.31e-24 |
|
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273317 [Multi-domain] Cd Length: 481 Bit Score: 107.04 E-value: 1.31e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 14 TQWYHFKAIIVAGMGLFTDAYDLFCIAPVMKMISHVYYNGdSINTAVLSTSY-----AIALLGTATGQLVFGYLGDRVGR 88
Cdd:TIGR00879 22 TYWKVALLSLIAAIGGLMFGYDTGVIGGALALPAFEFKFT-SANSDSYSSSLwglvvSIFLVGGFIGALFAGWLSDRFGR 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 89 RRvyglCLIIMILSSFGCGFSVCTTRRSCVMVSLGFFRFFLGLGIGGDYPLSATIMSEFANKRTRGAFIAAVFSMQGLGI 168
Cdd:TIGR00879 101 KK----SLLIIALLFVIGAILMGLAAFALSVEMLIVGRVLLGIGVGIASALVPMYLSEIAPKALRGALTSLYQLAITFGI 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 169 LVSSAVTMAVCVAFKRSGgglevdaaapteadlaWRLILMIGALPAALTFYWRMLMPETARYtaLVENNIVQAAKdmqRV 248
Cdd:TIGR00879 177 LVAYGFGSGKVSLNNTLG----------------WRIPLGLQLIPAGLLFLGLFFLPESPRW--LVGKGRVEEAR---KS 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 249 MSRSHISDEATTDPPPPPPPPSYKLF---------SRCFFRLHGRDLFAAsfnwFLVDIVFYTSNLLLSHIFSHYSkkPS 319
Cdd:TIGR00879 236 LARLRGTSGEDKELLDELELIDIKRSiekrsvqpsWGSLFSSTRRIRRRL----FLGVVLQWFQQFTGINAIMYYS--PT 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 320 TAENV---YDAAFEVAELGAIIAACSTIPGYWFtvyfIDKIGRVKIQIMGFFFMAVIYLVAGIPYSWYWSKHEHNNKGFM 396
Cdd:TIGR00879 310 IFENAgvsTDHAFLVSIIVGAVNFAFTFVAIFL----VDRFGRRPLLLIGAAGMAICLFVLGILGASFVTGSSKSSGNVA 385
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 397 VLYGLVF-FFCNFGPNTTTFIIPAEHFPARFRSTCHGISGAAGKLGAIVGTVGFLWATKKMESDdknqiypevnrmrIAF 475
Cdd:TIGR00879 386 IVFILLFiAFFAMGWGPVPWVIVSEIFPLSLRPKGISIAVAANWLANFIVGFLFPTMLESIGVG-------------GVF 452
|
490 500
....*....|....*....|....*....
gi 15218057 476 LILGGVCIAGILVTYFFTKETMGRSLEEN 504
Cdd:TIGR00879 453 IFFGGLNVLGLIFVYFFLPETKGRTLEEI 481
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
17-496 |
1.34e-24 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 105.34 E-value: 1.34e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 17 YHFKAIIVAGMGLFTDAYDLFCIAPVMKMISHVYyngdSINTAVLSTSYAIALLGTATGQLVFGYLGDRVGRRRVYGLCL 96
Cdd:COG2271 7 YRWRILALLFLAYFLNYLDRSNLSVAAPPLQADL----GLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 97 IIMILSSFGCGFSVcttrrscVMVSLGFFRFFLGLGIGGDYPLSATIMSEFANKRTRGAFIAAVFSMQGLGILVSSAVTM 176
Cdd:COG2271 83 LLWGLATLLFGFAT-------SFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLG 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 177 AVCVAFkrsggglevdaaapteadlAWRLILMIGALPAALTFYWRMLMpetarytalvennivqaakdmqrvmsrshisd 256
Cdd:COG2271 156 WLLAAF-------------------GWRAAFLILGLPGLLLALLRFWL-------------------------------- 184
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 257 eattdppppppppsyklfsrcffrlhgrdlfaASFNWFLVDIVFYTSNLLLshifshyskkPSTAENVYDAAFEVAELGA 336
Cdd:COG2271 185 --------------------------------LALAYFLVYFALYGFLTWL----------PTYLVEVRGLSLAQAGLLL 222
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 337 IIAACSTIPGYWFTVYFIDKIGRVKIQIMGFFFMAVIYLVAGIPYSwywskhehNNKGFMVLYGLVFFFCNFGPNTTTFI 416
Cdd:COG2271 223 SLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALALLLLALL--------PSPALAIALLFLAGFGLGGAFGLLWA 294
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 417 IPAEHFPARFRSTCHGISGAAGKLGAIVGTVGFLWATkkmesddknqiypEVNRMRIAFLILGGVCIAGILVTYFFTKET 496
Cdd:COG2271 295 LAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLL-------------DATGYQAAFLLLAALALLAALLALLLLRET 361
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
17-450 |
2.34e-23 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 102.05 E-value: 2.34e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 17 YHFKAIIVAGMGLFTDAYDLFCIAPVMKMISHVYyngdSINTAVLSTSYAIALLGTATGQLVFGYLGDRVGRRRVYGLCL 96
Cdd:TIGR00895 14 YQWRAIILSFLIMLMDGYDLAAMGFAAPAISAEW----GLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSI 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 97 IIMILSSFGCGFSVCTTrrscvmvSLGFFRFFLGLGIGGDYPLSATIMSEFANKRTRGAFIAAVFSMQGLGILVSSAVtm 176
Cdd:TIGR00895 90 LLFSVFTLLCALATNVT-------QLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFL-- 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 177 avcvafkrsggglevdaAAPTEADLAWRLILMIGAL-PAALTFYWRMLMPETARYtaLVENNIVQAAKDMQRVMSRSHIS 255
Cdd:TIGR00895 161 -----------------AGWLIPVFGWRSLFYVGGIaPLLLLLLLMRFLPESIDF--LVSKRPETVRRIVNAIAPQMQAE 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 256 DEATTDPPPPPPPPSYKLFSRCFFRLHGRDLFAASFNWFLVDIVFYTSNLLLSHIFSHYSKKPSTAEnVYDAAFEVaelG 335
Cdd:TIGR00895 222 AQSALPEQKSTQGTKRSVFKALFQGKTARITVLLWLLYFMLLVGVYFLTNWLPKLMVELGFSLSLAA-TGGALFNF---G 297
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 336 AIIaacstipGYWFTVYFIDKIGRVkiQIMGFFFMAVIYLVAGipYSWYwskhehNNKGFMVLYGLVFFFCNFGPNTTTF 415
Cdd:TIGR00895 298 GVI-------GSIIFGWLADRLGPR--VTALLLLLGAVFAVLV--GSTL------FSPTLLLLLGAIAGFFVNGGQSGLY 360
|
410 420 430
....*....|....*....|....*....|....*..
gi 15218057 416 IIPAEHFPARFRSTCHGISGAAGKLGAIVG--TVGFL 450
Cdd:TIGR00895 361 ALMALFYPTAIRATGVGWAIGIGRLGAIIGpiLAGYL 397
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
66-495 |
1.69e-22 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 99.18 E-value: 1.69e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 66 AIALLGTATGQLVFGYLGDRVGRRRVYGLCLIIMILSSFGCGFSVCTTrrscvmvSLGFFRFFLGLGIGGDYPLSATIMS 145
Cdd:cd17359 43 SSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFT-------IFIIARIIGGLAVGGASALVPMYIA 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 146 EFANKRTRGAFIaavfSMQGLGILVSSAVTMAVCVAFKRSGGGLEVDAAapteadlAWRLILMIGALPAALTFYWRMLMP 225
Cdd:cd17359 116 EVAPAEIRGRLV----SLNQLMIVFGQLLAYIVNYLIANAGGADWLGAE-------GWRWMLGLEAIPAILFLLGMLFIP 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 226 ETARYTALVENNIVQAAkdmqrvmsrshisdeattdppppppppsyklfsrcffrlhgrdLFAASFNWFL-VDIVFYTSN 304
Cdd:cd17359 185 ESPRWLVSKGKPILIIG-------------------------------------------IGLAIFQQFVgINVIFYYGP 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 305 LLLSHIFshYSKKPSTAENVYDAAFEVaeLGAIIAacstipgywftVYFIDKIGRVKIQIMGFFFMAVIYLVAGIpysWY 384
Cdd:cd17359 222 EIFQNAG--FSENAALLQTIGIGVVNV--IFTIIA-----------ILLVDKVGRKPLLLIGSIGMAISLLLIGT---AF 283
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 385 WSKHEHNNKGFMVLYGLVFF--FCNFGPNTTTFIIPAEHFPARFRSTCHGISGAAGKLGAIVGTVGFLWATKKMEsddkn 462
Cdd:cd17359 284 YFAPGSQASGIVALVLILLFvaFFAMSWGPVTWVLLSEIFPNRIRGLAMGIAVFFLWIANFLVSLTFPILLAAFG----- 358
|
410 420 430
....*....|....*....|....*....|...
gi 15218057 463 qiypevnrMRIAFLILGGVCIAGILVTYFFTKE 495
Cdd:cd17359 359 --------LAFTFLIFAVICVLAFLFVWKFVPE 383
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
25-490 |
1.12e-21 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 96.73 E-value: 1.12e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 25 AGMGLFTDAYDLFCIAPVMKMISHVYyngdSINTAVLSTSYAIALLGTATGQLVFGYLGDRVGRRRVYGLCLIIMILSSF 104
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSF----GLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGAL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 105 GCGFSVcttrrscVMVSLGFFRFFLGLGIGGDYPLSATIMSEFANKRTRGAFIAAVFSMQGLGILVSSAVTMAVCVAFkr 184
Cdd:cd06174 77 LFAFAP-------SFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSL-- 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 185 sggglevdaaapteaDLAWRLILMIGALPAALTFYWRMLMPETARYTALVENNIVQAAKDMQRVMSRSHIsdeattdppp 264
Cdd:cd06174 148 ---------------GFGWRAVFLIAAALALLAAILLLLVVPDPPESARAKNEEASSKSVLKLLKRVLKN---------- 202
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 265 pppppsyklfsrcffrlhgRDLFAASFNWFLVDIVFYTSNLLLshifshyskkPSTAENVYDAAFEVAELGAIIAACSTI 344
Cdd:cd06174 203 -------------------PGLWLLLLAIFLVNLAYYSFSTLL----------PLFLLDLGGLSVAVAGLLLSLFGLAGA 253
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 345 PGYWFTVYFIDK-IGRVKIQIMGFFFMAVIYLVAGIPYSWYWskhehnnkgfMVLYGLVFFFCNFGPNTTTFIIPAEHFP 423
Cdd:cd06174 254 LGSLLLGLLSDRlIGRKPLLLIGLLLMALGLALLLLAPSLLL----------LLLLLLLLGFGLGGLLPLSFALIAELFP 323
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15218057 424 ARFRSTCHGISGAAGKLGAIVGTVGFLWatkkmesddknqIYPEVNRMRIAFLILGGVCIAGILVTY 490
Cdd:cd06174 324 PEIRGTAFGLLNTFGFLGGAIGPLLAGF------------LLAATFGLTGAFLVLAVLLLLAAILLL 378
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
28-450 |
1.38e-21 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 96.60 E-value: 1.38e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 28 GLFTDAYDLFCIAPVMKMIShVYYNGDSINTAVLSTsyaIALLGTATGQLVFGYLGDRVGRRRVYGLCLIIMILSSFGCG 107
Cdd:cd17371 7 GWALDGFDLLLLGLVLPALI-AEFGLDEAEAGLLGT---VTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 108 FSVCTTRrscvmvsLGFFRFFLGLGIGGDYPLSATIMSEFANKRTRGAFIAAVFSMQGLGILVSSAVTMAVcvafkrsgg 187
Cdd:cd17371 83 FAQNYWQ-------LLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALL--------- 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 188 glevdaAAPTEADLAWRLILMIGALPAALTFYWRMLMPETARYTalvennivQAAKDMQRVMSRSHIsdeattdpppppp 267
Cdd:cd17371 147 ------FPLLPPEIAWRVLFLLGALPALLVLFIRRFVKEPPQWQ--------AARAARRHFADRPSL------------- 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 268 ppsYKLFSRCFFRLhgrdlfaaSFNWFLVDIVFYTSNLLLSHIFshyskkPSTAENVYDAAFEVAELGAIIAACSTIPGY 347
Cdd:cd17371 200 ---RELFSPPLLRT--------TLLASLLATGALGGYYGITTWL------PSYLTGERGLSFEGSAGYLVVTILGGFLGY 262
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 348 WFTVYFIDKIGRVKIQIMgFFFMAVIYLVAGIPYswywskheHNNKGFMVLYGLVFFFCNFGPNTTTFIIPAEHFPARFR 427
Cdd:cd17371 263 LAGGFLADRIGRRNNFAL-FALGSAISILLYFFL--------PLSPTLILILGFPLGFFASGPFSGMGAYLTELFPTAVR 333
|
410 420
....*....|....*....|....*
gi 15218057 428 STCHGISGAAGKLGAIVG--TVGFL 450
Cdd:cd17371 334 ATAQGFCYNVGRIIGALFpfLVGFL 358
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
17-492 |
2.37e-20 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 93.02 E-value: 2.37e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 17 YHFKAIIVAGMGLFTDAYDLFCIAPVMKMISHVYyngdSINTAVLSTSYAIALLGTATGQLVFGYLGDRVGRRRVYGLCL 96
Cdd:COG2223 2 GRWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEF----GLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 97 IIMILSSFGCGFSVcttrrscVMVSLGFFRFFLGLGIGGDYPLSATIMSEFANKRTRGAFIAAVFSMQGLGILVSSAVTM 176
Cdd:COG2223 78 LLLGIGLLLLALAV-------SYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAP 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 177 AVCVAFkrsggglevdaaapteadlAWRLILMI-GALPAALTFYWRMLMPETARYTALVENNIVQAAKDMqrvmsrshis 255
Cdd:COG2223 151 LLIAAF-------------------GWRNAFLIlGILLLVVAVLAWLFLRDPPAGAAAAAKASLRDQLEA---------- 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 256 deattdppppppppsyklfsrcffrLHGRDLFAASFNWFLVDIVFYTSNLLLSHIFSHYSKKPSTaenvydAAFEVAELG 335
Cdd:COG2223 202 -------------------------LRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAA------TAGLLAALF 250
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 336 AIIAACSTIPGYWFTvyfiDKIGRVKIQIMGFFFMAVIYLVAGIPYSWYWskhehnnkGFMVLYGLVFFFCNFGpNTTTF 415
Cdd:COG2223 251 ALLGALGRPLGGWLS----DRIGGRRVLLIVFALMALGLLLLALALGSLW--------LFLVLFLLLGLALGGG-NGAVF 317
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15218057 416 IIPAEHFPARFRSTCHGISGAAGKLGAIVGTVGFLWATKKMESddknqiypevnrMRIAFLILGGVCIAGILVTYFF 492
Cdd:COG2223 318 ALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGS------------YTAAFLVFAVLALVALVLTLLL 382
|
|
| MFS_GLUT6_8_Class3_like |
cd17358 |
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ... |
70-503 |
9.83e-19 |
|
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340916 [Multi-domain] Cd Length: 436 Bit Score: 88.79 E-value: 9.83e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 70 LGTATGQLVFGYLGDRVGRRRVYGLCLIIMIlssfgCGFSVCTTRRSCVMVSLGffRFFLGLGIGGDYPLSATIMSEFAN 149
Cdd:cd17358 52 LGALIGALLSGKLADRIGRKRTLLISAIPCI-----LGWLLIAFAKDVWMLYLG--RFLAGFGGGAASVVVPVYIAEIAP 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 150 KRTRGAFIAAVFSMQGLGILVSSAVTMAVcvafkrsggglevdaaapteadlAWRLILMIGALPAALTFYWRMLMPETAR 229
Cdd:cd17358 125 KNVRGALGSLNQLLVNIGILLGYVLGSFL-----------------------PWRTLALIGAIPPVVFLILLFFIPESPR 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 230 YtaLVENNIVQAAKDMQRVM--SRSHISDEAT--TDPPPPPPPPSYKLFSRCFFRLHGRDLFAASFNWFLVD-------I 298
Cdd:cd17358 182 W--LAKKGREEEAEKSLQFLrgKDADISKEAAeiQEELAELEKEAKESSFSDLFQRKYLKPLVIGLGLMLFQqlsginaV 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 299 VFYTSNlllshIFshyskkpSTAENVYDaafevAELGAIIAACSTIPGYWFTVYFIDKIGRVKIQIMGFFFMAVIYLVAG 378
Cdd:cd17358 260 IFYASS-----IF-------DEAGSGLD-----PNTATIIIGVVQVVGTLVATLLVDRLGRRPLLLVSAIGMGIGLLALG 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 379 IpYSWYWSKHE-HNNKGFMVLYGLVFF--FCNFGPNTTTFIIPAEHFPARFRSTCHGISGAAGKLGAIVGTVGFlwatkk 455
Cdd:cd17358 323 L-YFYLQEHGAlLSSVSWLPLVGLVIYiiSFSIGLGPLPWVIMSEIFPAKIKGLAGSLVTLVNWLFAFIVTKTF------ 395
|
410 420 430 440
....*....|....*....|....*....|....*....|....*...
gi 15218057 456 mesddknQIYPEVNRMRIAFLILGGVCIAGILVTYFFTKETMGRSLEE 503
Cdd:cd17358 396 -------PFLTLAWGASGTFWIFAGICGLALVFVLLFVPETKGKSLEE 436
|
|
| MFS_HXT |
cd17356 |
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ... |
22-503 |
4.17e-17 |
|
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340914 [Multi-domain] Cd Length: 403 Bit Score: 83.45 E-value: 4.17e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 22 IIVAGMGLFTDAYDLFCIAPVMKMISHVYYNGDSINTAVLSTS-----YAIALLGTATGQLVFGYLGDRVGRRR-VYGLC 95
Cdd:cd17356 3 CAFVSLGGFLFGYDTGSISGILNMKSFQKYFADNTGTYYPSSSrqgliVSIVNLGSFFGALISSFLSDRIGRKKsIQIGC 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 96 LIIMIlssfGCGFSVCTT-RRSCVMVSlgffRFFLGLGIGGDYPLSATIMSEFANKRTRGAFIAAVFSMQGLGILVSSAV 174
Cdd:cd17356 83 VIYII----GAIIQVAAIgKWYQLIVG----RIIAGLGVGFASVLVPVYQSEVAPKHIRGTLVSLYQLAITIGILVAYCI 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 175 TMAVCVAFKRSggglevdaaapteadlAWRLILMIGALPAALTFYWRMLMPETARYtalvennivqaakdMQRVMsrshi 254
Cdd:cd17356 155 NYGTHKLDGSA----------------QWRIPLGLQIVWGLLLLIGMFFLPESPRW--------------LYRTI----- 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 255 sdeattdppppppppsyklfsrcffrlhgrdlFAASFNWFL----VDIVFYTSNLllshIFSHYSKKPSTAenvydaaFE 330
Cdd:cd17356 200 --------------------------------LGIMLQLFQqltgINYFFYYGTT----IFQSTGLTGSSP-------LL 236
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 331 VAELGAIIAACSTIPGywftVYFIDKIGRVKIQIMGFFFMA---VIYLVAGIPYSWYWSKHEHNNKG-------FMVLYG 400
Cdd:cd17356 237 TSIILYIVNFVSTIPG----LFFVDKFGRRTCLLIGAAGMSiclFIYAAVGVRYLIPNPQSGTSNKSagngmivFICLFI 312
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 401 LvFFFCNFGPntTTFIIPAEHFPARFRSTCHGISGAAGKLGAIVGTVgflwATKKMesddknqiypeVNRMRIA-FLILG 479
Cdd:cd17356 313 F-SFATTWGP--IAWVYVAEVFPLRVRSKGMALATAFNWLWNFLISF----FTPFI-----------IGSIGFKyYYIFA 374
|
490 500
....*....|....*....|....
gi 15218057 480 GVCIAGILVTYFFTKETMGRSLEE 503
Cdd:cd17356 375 GCNLLAFIVVFFFVPETKGLTLEE 398
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
70-503 |
1.64e-16 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 82.37 E-value: 1.64e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 70 LGTATGQLVFGYLGDRVGRRRVYGLCLIIMILSSFGCGFSVCTTrrscVMVslgFFRFFLGLGIGGDYPLSATIMSEFAN 149
Cdd:TIGR00898 138 VGVLLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYT----VFL---VFRLLVGMGIGGIWVQAVVLNTEFLP 210
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 150 KRTRGAFIAAVFSMQGLGILVSSAVTMAVcvafkrsggglevdaaapteadLAWRLILMIGALPAALTFYWRMLMPETAR 229
Cdd:TIGR00898 211 KKQRAIVGTLIQVFFSLGLVLLPLVAYFI----------------------PDWRWLQLAVSLPTFLFFLLSWFVPESPR 268
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 230 YTaLVENNIVQAAKDMQRV--MSRSHISDE-----ATTDPPPPPPPPSYK-LFSRCFFRLHgrdLFAASFNWFLVDIVFY 301
Cdd:TIGR00898 269 WL-ISQGRIEEALKILQRIakINGKKLPAEvlslsLEKDLSSSKKQYSFLdLFRTPNLRKT---TLCLMMLWFTTAFSYY 344
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 302 TSNLLLSHIFShyskkpstaeNVYdaafevaeLGAIIAACSTIPGYWFTVYFIDKIGRVKIQIMGFFFMAVIYLVAG-IP 380
Cdd:TIGR00898 345 GLVLDLGNLGG----------NIY--------LDLFISGLVELPAKLITLLLIDRLGRRYTMAASLLLAGVALLLLLfVP 406
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 381 YSWYWskhehnnkgfmVLYGLVFF--FCNFGPNTTTFIIPAEHFPARFRSTCHGISGAAGKLGAIVGTVGFLwatkkmeS 458
Cdd:TIGR00898 407 VDLYF-----------LRTALAVLgkFGITSAFQMVYLYTAELYPTVVRNLGVGVCSTMARVGSIISPFLVY-------L 468
|
410 420 430 440
....*....|....*....|....*....|....*....|....*
gi 15218057 459 DDKNQIYPevnrmriaFLILGGVCIAGILVTYFFtKETMGRSLEE 503
Cdd:TIGR00898 469 GEKWLFLP--------LVLFGGLALLAGILTLFL-PETKGVPLPE 504
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
56-216 |
8.76e-16 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 78.78 E-value: 8.76e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 56 INTAVLSTSYAIALLGTATGQLVFGYLGDRVGRRRVYGLCLIIMILSSFGCGFSVCTTrrscvmvSLGFFRFFLGLGIGG 135
Cdd:cd17365 31 LSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVL-------QLALLRFLTGLGLGA 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 136 DYPLSATIMSEFANKRTRGAFIAAVFSMQGLGILVSSAVTMAVCVAFkrsggglevdaaapteadlAWRLILMIGALPAA 215
Cdd:cd17365 104 AMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAF-------------------GWRSVFLLGGVPPL 164
|
.
gi 15218057 216 L 216
Cdd:cd17365 165 I 165
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
24-495 |
1.19e-15 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 78.38 E-value: 1.19e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 24 VAGMGLFTDAYDLFCIAPVMKMISHVYynGDSINTAVLSTSYAIALLGTATGQLVFGYLGDRVGRRRVYGLCLIIMILSS 103
Cdd:cd17315 1 VAALGGLLFGYDLGVINGALLYIAKDL--GFGLSTSLQGLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGA 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 104 FGCGFSVcttrrSCVMVSLGffRFFLGLGIGGDYPLSATIMSEFANKRTRGAFIAAVFSMQGLGILVSSavtmAVCVAFK 183
Cdd:cd17315 79 LLSALAP-----NVWVLIVG--RFLLGLGVGLASVLVPLYISEIAPAKIRGALGTLNQLMITFGILLAY----LLGLALS 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 184 RSGGGLevdaaapteadlaWRLILMIGALPAALTFYWRMLMPETARYTALVENNIVQAAKDMQRVMsrshisdeattdpp 263
Cdd:cd17315 148 LSPPGW-------------WRLMFALAAVPALLQLLLMFFLPESRALLVGVGLQLLQQLTGINAVM-------------- 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 264 ppppppsyklfsrcffrlhgrdlfaasfnwflvdivFYTsnlllSHIFshyskkpSTAENVYDAAfevaeLGAIIAACST 343
Cdd:cd17315 201 ------------------------------------YYA-----PTIF-------KSAGGGTASI-----LASIIVGVVN 227
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 344 IPGYWFTVYFIDKIGRVKIQIMGFFFMAVIYLVAGIPYSWywsKHEHNNKGFMVLYGLVFFFCNF--GPNTTTFIIPAEH 421
Cdd:cd17315 228 LLATLVAIRLVDKVGRRPLLLIGFAGMAASLLLLAIAFLL---PALAKAAGWLALLGILLYIAAFamGAGPVPWLLLSEI 304
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15218057 422 FPARFRSTCHGISGAAGKLGAIVGTVGFLWATKKmesddKNQiypevnrmRIAFLILGGVCIAGILVTYFFTKE 495
Cdd:cd17315 305 FPLRIRGKGMAIATLVNWIFNFIVGLTFLIMVST-----IGL--------AGVFIFFAAVCLLALVFVFFFVPE 365
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
28-446 |
3.12e-13 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 70.91 E-value: 3.12e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 28 GLFTDAYDLFCIAPVMKMISHVYYNGDSINTAVLSTSYAialLGTATGQLVFGYLGDRVGRRRVYGLCLIIMILSSFGCG 107
Cdd:pfam07690 4 AAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFS---LGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 108 FSVcttrrscVMVSLGFFRFFLGLGIGGDYPLSATIMSEFANKRTRGAFIAAVFSMQGLGILVSSAVTMAVCVAFkrsgg 187
Cdd:pfam07690 81 FAS-------SLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLF----- 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 188 glevdaaapteadlAWRLILMIGALPAALTFYWRMLMPETArytalvennivqaakdmqrvmsrshisdEATTDPPPPPP 267
Cdd:pfam07690 149 --------------GWRAAFLILAILSLLAAVLLLLPRPPP----------------------------ESKRPKPAEEA 186
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 268 PPSYKLFSRCFFRLHGRDLFAASFNWFLVdIVFYTSNLLLSHIFSHYSkkpstaenVYDAAFEVAelgaiIAACSTIPGY 347
Cdd:pfam07690 187 RLSLIVAWKALLRDPVLWLLLALLLFGFA-FFGLLTYLPLYQEVLGLS--------ALLAGLLLG-----LGGLLGAIGR 252
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 348 WFTVYFIDKIGRVKIQIMGFFFMAVIYLVAGIpysWYWSKHEHNNKGFMVLYGLVFFFCnfgpNTTTFIIPAEHFPARFR 427
Cdd:pfam07690 253 LLLGRLSDRLGRRRRLLLALLLLILAALGLLL---LSLTLSSLWLLLALLLLGFGFGLV----FPALNALVSDLAPKEER 325
|
410
....*....|....*....
gi 15218057 428 STCHGISGAAGKLGAIVGT 446
Cdd:pfam07690 326 GTASGLYNTAGSLGGALGP 344
|
|
| MFS_SV2 |
cd17363 |
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic ... |
67-449 |
7.55e-13 |
|
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. The SV2 family belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340921 [Multi-domain] Cd Length: 474 Bit Score: 70.60 E-value: 7.55e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 67 IALLGTATGQLVFGYLGDRVGRRRVYGLCL----IIMILSSFGCGFSVcttrrscvmvsLGFFRFFLGLGIGGDYPLSAT 142
Cdd:cd17363 42 IVYLGMMVGAFVWGGLADKLGRKQCLLIALsvngVFAFLSSFVQGYGF-----------FLFCRLLSGIGIGGSIPIVFS 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 143 IMSEFANKRTRGAFIAAVFSMQGLGILVSSAVTMAVCVAFkrsGGGLEVDAAAPTEadlAWRLILMIGALPAALTFYWRM 222
Cdd:cd17363 111 YFAEFLAREKRGEHLSWLCMFWMIGGLYASAMAWAIIPHY---GWGFSMGTAYQFH---SWRVFVIVCALPSVASVVALT 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 223 LMPETARY-------------TALVENNIVQAAKDMQRVMSRSHISDEATTDPPPPPPPPSY------------------ 271
Cdd:cd17363 185 FMPESPRFllevgkhdeawmiLKQVHDTNMRAKGHPERVFTVSHIKRMNTLFLAIVWFTMSFsyygltvwfpdmikylqf 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 272 --KLFSRCFFR-LHGRDLFAAsfNWFLVDIVFYTSNL---------LLSHIFSHYSKKPSTAENVYDAAFEVAeLGAIIA 339
Cdd:cd17363 265 edSLFEECYFEdVTSTNTFFE--NCTFINTVFYNTDLfeykfidsrFLNSTFFLKEKCGCHLNDDEENAYLIY-LVSFLG 341
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 340 ACSTIPGYWFTVYFIDKIGRVKIqIMGFFFMAVI---YLVAGipyswywskhehNNKGFMVLYGLVFFFCNFGPNTTTFI 416
Cdd:cd17363 342 SLSVLPGNIVSALLMDKIGRLKM-IGGSMLLSAVccfFLFFG------------NSESAMIGLQCLFCGVSIAAWNALDV 408
|
410 420 430
....*....|....*....|....*....|...
gi 15218057 417 IPAEHFPARFRSTCHGISGAAGKLGAIVGTVGF 449
Cdd:cd17363 409 VTVELYPTDKRATAFGFLNGLCKLAAILGNSIF 441
|
|
| MFS_SV2A |
cd17439 |
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; ... |
24-445 |
1.02e-11 |
|
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. It is unclear how SV2A is involved in correct SV function, but it has been suggested to either act as a transporter or a regulator of exocytosis by mediating Ca2+ dynamics. SV2A has been identified as the molecular target of the antiepileptic drug levetiracetam (LEV). Its expression is decreased in patients with epilepsy and in epileptic animal models. SV2A belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340997 [Multi-domain] Cd Length: 478 Bit Score: 66.98 E-value: 1.02e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 24 VAGMGLFTDAYDLFCIAPVMKMISHVYYNGDSiNTAVLSTsyaIALLGTATGQLVFGYLGDRVGRRRVYGLCL----IIM 99
Cdd:cd17439 3 VLGLALMADGVEVFVVGFVLPSAEKDMCLSDS-NKGMLGL---IVYLGMMVGAFLWGGLADRIGRRQCLLISLsvnsVFA 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 100 ILSSFGCGFSvcttrrscvmvSLGFFRFFLGLGIGGDYPLSATIMSEFANKRTRGAFIAAVFSMQGLGILVSSAVTMAVC 179
Cdd:cd17439 79 FFSSFVQGYG-----------TFLFCRLLSGVGIGGSIPIVFSYFSEFLAQEKRGEHLSWLCMFWMIGGIYASAMAWAII 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 180 VAFkrsGGGLEVDAAAPTEadlAWRLILMIGALPAALTFYWRMLMPETARY-------------TALVENNIVQAAKDMQ 246
Cdd:cd17439 148 PHY---GWSFQMGSAYQFH---SWRVFVLVCAFPSVFAIGALTTMPESPRFflengkhdeawmvLKQVHDTNMRAKGHPE 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 247 RVMSRSHISDEATTDPPPPPPPPSY------------------------KLFSRCFFrlhgRDLFAASF---NWFLVDIV 299
Cdd:cd17439 222 RVFSVTHIKRRITLMMMAVWFTMSFsyygltvwfpdmikhlqksvvfedSLFEECYF----EDITSSNTffkNCTFISTL 297
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 300 FYTSNL---------LLSHIFSHYSKKP----STAENVYDAAFeVAELGAIiaacSTIPGYWFTVYFIDKIGRVKIqIMG 366
Cdd:cd17439 298 FYNTDLfeykfinskLINSTFLHNKEGClldfSDENNAYMIYF-VSFLGTL----AVLPGNIVSALLMDKIGRLRM-LAG 371
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 367 FFFMAVI---YLVAGipyswywskhehNNKGFMVLYGLVFFFCNFGPNTTTFIIPAEHFPARFRSTCHGISGAAGKLGAI 443
Cdd:cd17439 372 SSVMSCVscfFLSFG------------NSESAMIALLCLFGGVSIASWNALDVLTVELYPSDKRTTAFGFLNALCKLAAV 439
|
..
gi 15218057 444 VG 445
Cdd:cd17439 440 LG 441
|
|
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
22-227 |
1.42e-11 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 66.16 E-value: 1.42e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 22 IIVAGMGLFTDAYDLFCIAPVMKMISHVYYNGDSINTAVLSTS--YAIALLGTATGQLVFGYLGDRVGRRRVYGLCLIIM 99
Cdd:cd17367 1 ILGGSVGNLVEWYDWYVYAAFALYFAPQFFPSGDPTVALLSTAavFAVGFLMRPIGGWLFGRLADRIGRRAALTLSVSLM 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 100 ILSSFGCGfsvCTTRRSCVMVS----LGFFRFFLGLGIGGDYPLSATIMSEFANKRTRGAFIAAVFSMQGLGILVSSAVt 175
Cdd:cd17367 81 AAGSLVIA---VTPTYATIGIWapiiLLLARLLQGLSVGGEYGTSATYLSEVAPPGRRGFYSSFQYVTLIGGQLLALGV- 156
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 15218057 176 mavcvafkrsGGGLEVDAAAPTEADLAWRLILMIGALPAALTFYWRMLMPET 227
Cdd:cd17367 157 ----------LLVLQHTLGEDQMAAWGWRIPFLLGGVLAVVVLWLRRGLEET 198
|
|
| synapt_SV2 |
TIGR01299 |
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ... |
13-281 |
3.72e-11 |
|
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.
Pssm-ID: 130366 [Multi-domain] Cd Length: 742 Bit Score: 65.77 E-value: 3.72e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 13 RTQWYHFkaiIVAGMGLFTDAYDLFCIAPVMKMISHVYYNGDSiNTAVLSTsyaIALLGTATGQLVFGYLGDRVGRRRVY 92
Cdd:TIGR01299 163 RFQWALF---FVLGLALMADGVEVFVVGFVLPSAEKDLCIPDS-GKGMLGL---IVYLGMMVGAFFWGGLADKLGRKQCL 235
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 93 GLCL----IIMILSSFGCGFsvcttrrscvmvslGFF---RFFLGLGIGGDYPLSATIMSEFANKRTRGAFIAAVFSMQG 165
Cdd:TIGR01299 236 LICLsvngFFAFFSSFVQGY--------------GFFlfcRLLSGFGIGGAIPIVFSYFAEFLAQEKRGEHLSWLCMFWM 301
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 166 LGILVSSAVTMAVCVAFkrsGGGLEVDAAAPTEadlAWRLILMIGALPAALTFYWRMLMPETARY-------------TA 232
Cdd:TIGR01299 302 IGGIYAAAMAWAIIPHY---GWSFQMGSAYQFH---SWRVFVIVCAFPCVFAIGALTFMPESPRFflengkhdeawmiLK 375
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 15218057 233 LVENNIVQAAKDMQRVMSRSHISDEATTDPPPPPPPPSYKLFSRCFFRL 281
Cdd:TIGR01299 376 LIHDTNMRAKGHPEKVFSVNHIKTIHQEDELIEIESDTGTWYQRCFVRA 424
|
|
| MFS_GLUT_Class1_2_like |
cd17357 |
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ... |
48-499 |
3.74e-11 |
|
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340915 [Multi-domain] Cd Length: 447 Bit Score: 65.36 E-value: 3.74e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 48 HVYYNGDSINTAVLSTSYAIALLGTATGQLVFGYLGDRVGRRRVYGLCLIIMILSSfgCGFSVCTTRRSCVMvsLGFFRF 127
Cdd:cd17357 38 YGLNLSDSELDLLWSLIVSIFFIGGAIGSFISAFLANRFGRKNGLLISNALLVVSS--LLMFLSKSAKSPEL--LIFGRF 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 128 FLGLGIGGDYPLSATIMSEFANKRTRGAFiaAVFSMQG--LGILVSSAVTMAVCVAFKRSggglevdaaapteadlaWRL 205
Cdd:cd17357 114 LVGIACGLSTGFVPMYLQEISPSELRGAL--GSLTQIGvtLGILLGQVFGLPSVLGTETL-----------------WPY 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 206 ILMIGALPAALTFYWRMLMPETARYTALVENNIVQAAKDMQR----------VMSRSHISDEATTDPpppppppsyKLFS 275
Cdd:cd17357 175 LLFFPGIPALLQLAALPFFPESPKFLLISKGDEEEAEKSLKFlrgieddvdqELEEIKKESEQMGDQ---------KQVS 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 276 RCffrlhgrDLFAASFNW--FLVDIVFYTSNLL--LSHIFShYSKKPSTAENVYDAAFEVAELGAIIAA-CSTIPGYWFt 350
Cdd:cd17357 246 LM-------QLLRDPSLRlpLLLVLVVSASQQFsgINAIFF-YSTFIFENAGFSPQLAEWANLGIGIVNvLSTIVGPFL- 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 351 vyfIDKIGRVKIQIMGFFFMAV--IYLVAGIPYSWYWSKHEHNNKGFMVLYGLVFffcNFGPNTTTFIIPAEHFPARFRS 428
Cdd:cd17357 317 ---IEKVGRRPLLLISLSVCAValLLMSVFLFLSEQNSWMSYGCIVAIFLFIFFF---AIGLGPIPWFIGAELFPQAPRS 390
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15218057 429 TCHGISGAAGKLGAIVgtVGFlwatkkmesddknqIYPEVNRMRIA--FLILGGVCIAGILVTYFFTKETMGR 499
Cdd:cd17357 391 AAQSLGSSVNWTSNFI--VGM--------------AFPPLQSIGGGfvFIIFAIPCALFLLYLYRYLPETKGR 447
|
|
| MFS_HMIT_like |
cd17360 |
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ... |
24-495 |
8.05e-11 |
|
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340918 [Multi-domain] Cd Length: 362 Bit Score: 63.83 E-value: 8.05e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 24 VAGMGLFTDAYDLFCIAPVMKMIshvyynGDSINTAVLSTSY-----AIALLGTATGQLVFGYLGDRVGRRRVyglcliI 98
Cdd:cd17360 1 FAGIGGFLFGYDTGVISGALLYI------KDDLGEVVLSTGWqelivSSTVAGAAVGAAIGGWLNDRFGRRPC------I 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 99 MILSS-FGCGFSVCTTRRSCVMVSLGffRFFLGLGIGGDYPLSATIMSEFANKRTRGAFIAAVFSMQGLGILVSSAVTma 177
Cdd:cd17360 69 LLADAlFTIGAIVMAAAPNKEVLIVG--RVLVGLGVGIASMTVPLYIAEAAPPRIRGRLVTINVLFITGGQFVAYVIN-- 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 178 vcvafkrsggglevdaAAPTEADLAWRLILMIGALPAALTFYWRMLMPETARYTALVENNIVQAAKDMqrvmsrshisde 257
Cdd:cd17360 145 ----------------GAFSYLPGGWRWMLGLAAVPAVLQFIGLLFLPESPRWPSTRRALIVGCGLQA------------ 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 258 attdppppppppsyklfsrcFFRLHGrdlfaasFNwflvDIVFYTSNLLLSHIFShySKKPSTAenvydaafevaeLGAI 337
Cdd:cd17360 197 --------------------FQQFSG-------IN----TVMYYSATILQMAGFK--DNQNAIW------------LSLI 231
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 338 IAACSTIpGYWFTVYFIDKIGRVKIQIMGFFFMAVIYLVAGIpyswywskhehnnkgFMVLYGLVFFFCNFGPNTTT--F 415
Cdd:cd17360 232 VAGTNFI-FTIVGMYLIDKFGRRKLLLISLFGVIVALVVLAV---------------WLALVGLILYLAFFAPGMGPvpW 295
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 416 IIPAEHFPARFRSTCHGISGAAGKLGAIVGTVGFLWATKKMESDDknqiypevnrmriAFLILGGVCIAGILVTYFFTKE 495
Cdd:cd17360 296 TVNSEIYPLWARGTGGGCAAAVNWVFNLLVSQTFLTLTQAIGPYG-------------TFLLFAGLAVLGLIFIYFCVPE 362
|
|
| PRK03893 |
PRK03893 |
putative sialic acid transporter; Provisional |
13-253 |
1.17e-10 |
|
putative sialic acid transporter; Provisional
Pssm-ID: 179668 [Multi-domain] Cd Length: 496 Bit Score: 63.95 E-value: 1.17e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 13 RTQWyhfKAIIVAGMGLFTDAYDLFCIAPVMKMISHVYYNGDSINTAVLSTsyaiALLGTATGQLVFGYLGDRVGRRRVY 92
Cdd:PRK03893 16 RAQW---KAFSAAWLGYLLDGFDFVLITLVLTEVQGEFGLTTVQAASLISA----AFISRWFGGLLLGAMGDRYGRRLAM 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 93 GLCLIIMILSSFGCGFSVCTTrrscvmvSLGFFRFFLGLGIGGDYPLSATIMSEFANKRTRGAFIAAVFSMQGLGILVSS 172
Cdd:PRK03893 89 VISIVLFSVGTLACGFAPGYW-------TLFIARLVIGMGMAGEYGSSATYVIESWPKHLRNKASGFLISGFSIGAVVAA 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 173 AVTMAVCVAFkrsggglevdaaapteadlAWRLILMIGALPAALTFYWRMLMPETARYTALVENNivQAAKDMQRVMSRS 252
Cdd:PRK03893 162 QVYSLVVPVW-------------------GWRALFFIGILPIIFALWLRKNLPEAEDWKEKHAGK--APVRTMVDILYRG 220
|
.
gi 15218057 253 H 253
Cdd:PRK03893 221 E 221
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
64-445 |
1.36e-10 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 63.31 E-value: 1.36e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 64 SYAIALLGTATGQLVFGYLGDRVGRRRVYGLCLIIMILSSFGCGFsVCTTRRSCVM--VSLGFFRFFLGLGIGGDYPLSA 141
Cdd:cd17369 49 TFGVGFLARPLGGVVFGHFGDRIGRKKTLVLTLLLMGIATFLIGL-LPTYAQIGILapILLVLLRLLQGLALGGEWGGAV 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 142 TIMSEFANKRTRGAFIAAVFSMQGLGILVSSAVTMAVcvafkrsggglevdAAAPTEADL---AWRLILMIGALPAALTF 218
Cdd:cd17369 128 LMAVEHAPPKRRGFYGSFPQLGAPVGLLLATGVFLLL--------------SALLSDEAFlswGWRIPFLLSAVLVAVGL 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 219 YWRMLMPETARYTALVENNIVQAAKDMQrvmsrshisdeattdppppppppsyklfsrcFFRLHGRDLFAASFNWFLVDI 298
Cdd:cd17369 194 YIRLRLEETPVFRRAKEAGQVVRAPLVE-------------------------------VLRRHWRALLLAIGLRLAENV 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 299 VFYTSNlllshIFShyskkPSTAENVYDAAFEVAELGAIIAACSTIPGYWFTVYFIDKIGRVKIQIMGfffmAVIYLVAG 378
Cdd:cd17369 243 LFYLFT-----TFA-----LSYATQTLGVDRSTVLLAVLIASVVAAITIPLFGWLSDRVGRRPVYLAG----ALLAALFA 308
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15218057 379 IPYswYWSKHEHNNK--------GFMVLYGLVfffcnFGPNTTTFiipAEHFPARFRSTchGISGAAgKLGAIVG 445
Cdd:cd17369 309 FPF--FWLLDTGSTWlivlaavvVLGVLHGMM-----YGPQAAFL---AELFPTRVRYT--GASLGY-QLGAILG 370
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
60-492 |
2.03e-10 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 62.59 E-value: 2.03e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 60 VLSTSYAIALLgtaTGQLVFGYLGDRVGRRRVYGLCLIIMILSSFGCGFSvcttrRSCVMvsLGFFRFFLGLGIGGDYPL 139
Cdd:cd17325 35 LIVAAYALAQL---LFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFA-----TSYWQ--LLLARFLQGLASAAVWPA 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 140 SATIMSEFANKRTRGAFIAAVFSMQGLGILVSSAVtmavcvafkrsgGGLEVDAaapteadLAWRLILMIGALPAALTFY 219
Cdd:cd17325 105 AMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLL------------GGLLADA-------LGYRAPFLVCAALALLALV 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 220 WRMLMPEtarytalvENNIVQAAKDMQRVMSRSHIsdeattdppppppppsyklfsrcFFRLHGRDLFAASFNWFLVDIV 299
Cdd:cd17325 166 LALLLLP--------EPRPPPNKRAVSAARLRSGL-----------------------RLLLRDRRLLALFLAIFVLAFA 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 300 FYTSNLLLshifshyskkPSTAENVYDaaFEVAELGAIIAACS--TIPGYWFTVYFIDKIGRVKIQIMGFFFMAVIYLVA 377
Cdd:cd17325 215 FGALEPFL----------PLYAAELGG--LSPAQIGLLFGAQGlaSALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLL 282
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 378 GIPYSWYWSkhehnnKGFMVLYGLVFFFCNfgPNTTTFIipAEHFPARFRSTCHGISGAAGKLGAIVGTV--GFLWATkk 455
Cdd:cd17325 283 PLATSFWLL------LLLLALLGLGLGLVF--PATLALL--ADIVPPEGRGTAMGLFNTAFSLGMVLGPLlgGFLYDA-- 350
|
410 420 430
....*....|....*....|....*....|....*..
gi 15218057 456 mesddknqiypevNRMRIAFLILGGVCIAGILVTYFF 492
Cdd:cd17325 351 -------------FGFATPFLAAAALLLLAAVLFLLL 374
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
63-170 |
6.43e-10 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 60.65 E-value: 6.43e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 63 TSYaiaLLGTATGQLVFGYLGDRVGRRRVYGLCLIIMILSSFGCGFSvcttrRScvMVSLGFFRFFLGLGIGGDYPLSAT 142
Cdd:cd17502 37 TAY---LLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLA-----PN--MTMLIVGRAIQGIGGGGLMSLAFI 106
|
90 100
....*....|....*....|....*...
gi 15218057 143 IMSEFANKRTRGAFIAAVFSMQGLGILV 170
Cdd:cd17502 107 IIADLVPPRERGKYQGYIGAVFGIASVA 134
|
|
| MFS_ProP |
cd17366 |
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This ... |
22-211 |
1.10e-09 |
|
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of Escherichia coli proline/betaine transporter, also called proline porter II (PPII), and similar proteins. ProP is a proton symporter that senses osmotic shifts and responds by importing osmolytes such as proline, glycine betaine, stachydrine, pipecolic acid, ectoine and taurine. It is both an osmosensor and an osmoregulator which is available to participate early in the bacterial osmoregulatory response. The ProP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340924 [Multi-domain] Cd Length: 377 Bit Score: 60.45 E-value: 1.10e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 22 IIVAGMGLFTDAYDLFCIAPVMKMISHVYYNGDSINTAVLST--SYAIALLGTATGQLVFGYLGDRVGRRRVYGLCLIIM 99
Cdd:cd17366 1 VKAAALGNAMEWFDFGVYGYLAVTIGKVFFPGGDPTAQLLATfaTFAVAFLVRPLGGLVFGPLGDKYGRQKVLAITIILM 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 100 ILSSFGCGF-SVCTTRRSCVMVSLGFFRFFLGLGIGGDYPLSATIMSEFANKRTRGaFIAAVFSMQGLGILVSSAVTMAV 178
Cdd:cd17366 81 AASTFCIGLlPTYATIGVWAPILLLLARMVQGFSTGGEYGGAATFVAEYAPDRKRG-FLGSWLEFGTLAGFILGAGLVTL 159
|
170 180 190
....*....|....*....|....*....|....*.
gi 15218057 179 CvafkrsggglevdAAAPTEADL---AWRLILMIGA 211
Cdd:cd17366 160 L-------------TLLLTEAQMldwGWRIPFLIAA 182
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
22-171 |
1.25e-09 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 59.87 E-value: 1.25e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 22 IIVAGMGLFTDAYDLFCIAPVMKMISHVYynGDSINTAVLSTS-YAIALlgtATGQLVFGYLGDRVGRRRVYGLCLIIMI 100
Cdd:cd17324 1 LLALALAAFAIGTTEYVIQGLLPDIARDF--GVSVAQAGLLVSaYALGY---ALGALLLGPLSDRIERRRLLLVLLLLFI 75
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15218057 101 LSSFGCGFSVcttrrscVMVSLGFFRFFLGLGIGGDYPLSATIMSEFANKRTRGAFIAAVFSMQGLGILVS 171
Cdd:cd17324 76 LGNLLAALAP-------SFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLG 139
|
|
| MFS_SV2B |
cd17438 |
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; ... |
23-449 |
1.41e-09 |
|
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2B is a key modulator of amyloid toxicity at the synaptic site and also has an essential role in the formation and maintenance of the glomerular capillary wall. SV2B belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340996 [Multi-domain] Cd Length: 477 Bit Score: 60.32 E-value: 1.41e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 23 IVAGMGLFTDAYDLFCIAPVMKMISHVYYNGDSiNTAVLSTsyaIALLGTATGQLVFGYLGDRVGRRRVYGLCLII---- 98
Cdd:cd17438 2 FVLGLALMADGVEVFVVGFVLPSAEKDMCLSSS-NKGMLGL---IVYLGMMAGAFIWGGLADKLGRKRCLIISLAInasf 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 99 MILSSFGCGFSVcttrrscvmvsLGFFRFFLGLGIGGDYPLSATIMSEFANKRTRGAFIAAVFSMQGLGILVSSAVTMAV 178
Cdd:cd17438 78 AFLSSFVQGYGA-----------FLFCRLISGFGIGGSLPIVFAYFSEFLAREKRGEHLSWLCMFWMIGGLYASAMAWSI 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 179 CVAFkrsGGGLEVDAAAPTEadlAWRLILMIGALPAALTFYWRMLMPETARY---------TALVENNI----VQAAKDM 245
Cdd:cd17438 147 IPHY---GWGFSMGTNYHFH---SWRVFVIICALPCIASIIALKFMPESPRFllemgkhdeAWMILKNIhdtnMRAKGTP 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 246 QRVMSRSHISDEATTDPPPPPPPPSYK------------------------LFSRCFFrlhgRDLFAASF---NWFLVDI 298
Cdd:cd17438 221 EKVFTVSNIKRKNTLFLAVVWFTMAFSyygltvwfpdmirylqkhvtfedsLFDECYF----EDVTSTDTyfkNCTIEST 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 299 VFYTSNlLLSHIFSHYSKKPSTAENVYDAA---FE-----VAELGAIIAACSTIPGYWFTVYFIDKIGRVKIqIMGFFFM 370
Cdd:cd17438 297 IFYNTD-LYEHKFIDCRFINSTFLEQKEGChmdFEedndfLIYLVSFLGSLSVLPGNIISALLMDKIGRIKM-IGGSMLI 374
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 371 AVI---YLVAGipyswywskhehNNKGFMVLYGLVFFFCNFGPNTTTFIIPAEHFPARFRSTCHGISGAAGKLGAIVGTV 447
Cdd:cd17438 375 SAVccfFLFFG------------NSESAMIGWQCLFCGTSIAAWNALDVITVELYPTNKRATAFGILNGLCKFAAILGNS 442
|
..
gi 15218057 448 GF 449
Cdd:cd17438 443 IF 444
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
61-492 |
2.08e-09 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 59.13 E-value: 2.08e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 61 LSTSYAIALLGTATGQLVFGYLGDRVGRRRVYGLCLIIMILSSFGCGFSvctTRRSCVMVslgfFRFFLGLGIGGDYPLS 140
Cdd:cd17317 27 VALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFS---PSYELFLV----LRFLVGVTSAGIFTVG 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 141 ATIMSEFankrTRGAFIAAVFSMQGLGILVSSAVTMAVCVAFKRsggglevdaaapteadlaWRLILMIGALPAALTFYW 220
Cdd:cd17317 100 FVLGMEI----VGPKYRSFVGILFGLFWALGYMLLALLAYLIRD------------------WRWLQLAISLPGLLFLLL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 221 RMLMPetarytalvennivqaakdmqrvmsrshisdeattdppppppppsyklfsrcffrlhgRDLFAASFNWFLVDIVF 300
Cdd:cd17317 158 LWWLP----------------------------------------------------------RRTIIVGLIWFVTSLVY 179
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 301 YTsnLLLShifshyskKPSTAENVYdaafevaeLGAIIAACSTIPGYWFTVYFIDKIGRvKIQIMGFFFMAVIYLVAgip 380
Cdd:cd17317 180 YG--LSLN--------SSNLGGNLY--------LNFFLSGLVEIPAYFLALLLLDRLGR-RWTLSGSLLLAGLACLV--- 237
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 381 ySWYWSKHEHNNKgfMVLYgLVFFFCNFGPNTTTFIIPAEHFPARFRSTCHGISGAAGKLGAIVGtvGFLWATKKmesdd 460
Cdd:cd17317 238 -TALLPDDENTLA--LTLA-LVGKFAISAAFSVIYLYTAELYPTVVRNTGVGLCSTVARVGAILA--PFIVLLGK----- 306
|
410 420 430
....*....|....*....|....*....|..
gi 15218057 461 knqIYPevnrmRIAFLILGGVCIAGILVTYFF 492
Cdd:cd17317 307 ---IGP-----LLPLIIFGVLALLGGLLTLLL 330
|
|
| MFS_GLUT8_Class3 |
cd17433 |
Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of ... |
66-503 |
8.30e-09 |
|
Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 8 (GLUT8) is also called Solute carrier family 2, facilitated glucose transporter member 8 (SLC2A8) or glucose transporter type X1 (GLUTX1). It is classified as a Class 3 GLUT protein and is an insulin-regulated facilitative glucose transporter predominantly expressed in testis and brain. It can also transport fructose and galactose. SLC2A8 knockout mice were viable, developed normally, and display only a very mild phenotype, including mild alterations in the brain (increased proliferation of hippocampal neurons), heart (impaired transmission of electrical wave through the atrium), and sperm cells (reduced number of motile sperm cells). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340991 [Multi-domain] Cd Length: 416 Bit Score: 57.58 E-value: 8.30e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 66 AIALLGTATGQLVFGYLGDRVGRRRVYGLCLIIMILssfgcGFSVCTTRRSCVMVSLGffRFFLGLGIGGDYPLSATIMS 145
Cdd:cd17433 48 SVVTLGAAAGGVLGGWIVDRAGRKLSLMLCSVPFIA-----GFTVITAAQNVWMLYVG--RLLTGLASGVTSLVVPVYIS 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 146 EFANKRTRGAFIAAVFSMQGLGILVSSAVtmavcvafkrsggGLEVDaaapteadlaWRLILMIGALPAALTFYWRMLMP 225
Cdd:cd17433 121 EIAHPRVRGTLGSCVQLMVVIGIMGAYLA-------------GLVLD----------WRWLAVLGSIPPTLMLLLMCFMP 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 226 ETARYtaLVENNIVQAAKDMQRVMSRShisdEATTDPPPPPPPPSYKLFSRCFFRLHGRDlfAASFNWFLVDIVfytsnL 305
Cdd:cd17433 178 ETPRF--LLTQHRRQEAMAALRFLRGP----DQGWEWECIGIEQSFHLEEQSFSLALLKQ--PGIYKPLIIGVS-----L 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 306 LLSHIFSHYSKKPSTAENVYDAA-FEVAELGAIIAACSTIPGYWFTVYFIDKIGRVKIQIMGFFFMAVIYLVAgipyswy 384
Cdd:cd17433 245 MAFQQLTGINAVMFYAETIFEEAkFKDSSVASVIVAAIQVLFTAVAALIMDRAGRKVLLVLSGVVMVFSTAAF------- 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 385 wskhehnnkGFMVLYGLVFFFCNF--GPNTTTFIIPAEHFPARFRSTCHGISGAAGKLGAIVGTVGFlwatkkmesddkn 462
Cdd:cd17433 318 ---------GWLAVGSMGFFIAGFavGWGPIPWLVMSEIFPLHVRGVASGICVLTNWLMAFLVTKEF------------- 375
|
410 420 430 440
....*....|....*....|....*....|....*....|.
gi 15218057 463 QIYPEVNRMRIAFLILGGVCIAGILVTYFFTKETMGRSLEE 503
Cdd:cd17433 376 SSLMEVLSSYGTFWLFSAFCAFSVLFTLFCVPETKGKTLEQ 416
|
|
| PRK10406 |
PRK10406 |
alpha-ketoglutarate transporter; Provisional |
6-228 |
4.33e-08 |
|
alpha-ketoglutarate transporter; Provisional
Pssm-ID: 182433 [Multi-domain] Cd Length: 432 Bit Score: 55.58 E-value: 4.33e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 6 LSSLDVARTQWyhfkAIIVAGMGLFTDAYDLFCIAPVMKMISHVYYNGDSINTAVLSTS--YAIALLGTATGQLVFGYLG 83
Cdd:PRK10406 12 LTSSDTRRRIW----AIVGASSGNLVEWFDFYVYSFCSLYFAHIFFPSGNTTTQLLQTAgvFAAGFLMRPIGGWLFGRIA 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 84 DRVGRRRVYGLCLIIMILSSF--GC--GFSVCTTRRSCVMVslgFFRFFLGLGIGGDYPLSATIMSEFANKRTRGaFIAa 159
Cdd:PRK10406 88 DKHGRKKSMLISVCMMCFGSLviAClpGYETIGTWAPALLL---LARLFQGLSVGGEYGTSATYMSEVAVEGRKG-FYA- 162
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15218057 160 vfSMQGLGILVSSAVTMAVCVAFKRSGGGLEVDAaapteadLAWRLILMIGALPAALTFYWRMLMPETA 228
Cdd:PRK10406 163 --SFQYVTLIGGQLLALLVVVVLQQTLEDAELRE-------WGWRIPFALGAVLAVVALWLRRQLDETS 222
|
|
| MFS_GLUT_Class2 |
cd17432 |
Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ... |
70-503 |
4.33e-08 |
|
Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT5, also called Solute carrier family 2, facilitated glucose transporter member 5 (SLC2A5), is a well-established fructose transporter found in the small intestine. GLUT7 (or SLC2A7) is a high-affinity glucose and fructose transporter expressed in the small intestine and colon. GLUT9 (or SLC2A9) transports urate and fructose, and is most strongly expressed in the basolateral membranes of proximal renal tubular cells, liver and placenta. It may play a role in urate reabsorption by proximal tubules. GLUT11 (or SLC2A11) is a facilitative glucose transporter expressed in heart and skeletal muscle. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340990 [Multi-domain] Cd Length: 452 Bit Score: 55.70 E-value: 4.33e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 70 LGTATGQLVFGYLGDRVGRRRVYGLCLIIMILSSFGCGFSVCTTRRSCVMVSlgffRFFLGL--GIGgdypLSATIM--S 145
Cdd:cd17432 61 LGGLFGSLLVGPLVIRLGRKGTLLLNNIFAIVAAILMGLSKIAKSFEMIIVG----RFLVGInaGIS----LNVVPMylG 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 146 EFANKRTRGAfiaavfsmqglgILVSSAVTMAVCVAFKRSGGGLEVDAAAPTeadlaWRLILMIGALPAALTFYWRMLMP 225
Cdd:cd17432 133 ESAPKNLRGA------------VGLVPAIFITLGILLGQVLGLRELLGNEEG-----WPLLLALTGVPALLQLLTLPFFP 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 226 ETARYTALVENNIVQAAKDMQRVMSRSHISDEATTDPPPPPPPPSYKLFSRC-FFRLHgrdlfaaSFNWFLVDIVFYTSN 304
Cdd:cd17432 196 ESPRYLLIEKGDEEAARKALQRLRGKEDVDDEMEEMLEEQRAEKGVGTVSVLeLFRDR-------SVRWQLISIIVLMAG 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 305 LLLSHIFSHYskkpSTAENVYDAA------FEVAELGaiIAACSTIPGYwFTVYFIDKIGRVKIQIMGFFFMAV------ 372
Cdd:cd17432 269 QQLCGINAIY----FYADSIFLEAgipedkIQYVTVG--TGACEVLATI-TCVLVIERLGRRPLLIGGFGLMAVwcavlt 341
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 373 --IYLVAGIPYSWYWSkhehnnkgfMVL-YGLVFFFCnFGPNTTTFIIPAEHFPARFRSTCHGISGAAGKLGAIvgTVGF 449
Cdd:cd17432 342 vaLSLQNTVSWMPYLS---------IVCiFAYIASFG-IGPAGVPFILTTEIFDQSSRPAAFMVAGSLNWLSNF--LVGL 409
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*.
gi 15218057 450 lwatkkmesddknqIYP--EVNRMRIAFLILGGVCIAGILVTYFFTKETMGRSLEE 503
Cdd:cd17432 410 --------------LFPfiQEGLGAYCFLVFAVICLLTAIYIFFVLPETKGKTFLE 451
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
76-492 |
7.53e-08 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 54.50 E-value: 7.53e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 76 QLVFGYLGDRVGRRRVYGLCLIIMILSSFGCGFSVCTTrrscvmvSLGFFRFFLGLGIGGDYPLSATIMSEFANKRTRGA 155
Cdd:cd17474 51 MPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFA-------LLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAK 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 156 FIAAVFSMQGLGILVSSAVtmavcvafkrsGGGLevdaaapteADLAWRLILMIGALPAALTF-YWRMLMPETARytalv 234
Cdd:cd17474 124 AMGLYEAALGLGIAVGPLL-----------GGLL---------AAISWRYPFFLLAALIPVAFlAILFLLPEPKE----- 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 235 ennivqaakdmqrvmsrshisdeattdpppPPPPPSYKLFSRCFFRLHGRDLFAASFNWFLVDIVFYTsnlllshiFSHY 314
Cdd:cd17474 179 ------------------------------KAKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFA--------FLTY 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 315 SkkPSTAENVYDAA-----FEVAELGAIIAACSTIPGYWFTvyfiDKIGRVKIQIMGFFFMAVIYLVAGIPYSWYWSkhe 389
Cdd:cd17474 221 L--PFLLELLYGISpiiigLLFAGWSVLLALGSLFVGRLLK----KRFGARRILVIGLLLYALSLLLLGFVPSLALL--- 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 390 hnnKGFMVLYGLVFFFCNfgPNTTTFIipAEHFPARFRSTCHGISGAAGKLGAIVGTVGFLWATkkmesddknqiypEVN 469
Cdd:cd17474 292 ---LIAIVLFGLGLGLNL--PLLTTLV--TELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLL-------------EIF 351
|
410 420
....*....|....*....|...
gi 15218057 470 RMRIAFLILGGVCIAGILVTYFF 492
Cdd:cd17474 352 GLSAPFLVGAAIALAAAVLLALL 374
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
39-230 |
1.52e-07 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 53.73 E-value: 1.52e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 39 IAPVMKMISHvYYNGDSINTAVLSTSYaiaLLGTATGQLVFGYLGDRVGRRRVYGLCLIIMILSSFGCGFSvcttrrSCV 118
Cdd:cd17320 18 YLPALPAIAR-DLGASASAVQLTLSAY---LLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALA------SSI 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 119 MVsLGFFRFFLGLGIGGDYPLSATIMSEFANKRTRgafiAAVFSMQGLGILVSSAVTMAVcvafkrsgGGLEVDAaapte 198
Cdd:cd17320 88 EQ-LLIARFLQGLGAAAGSVVARAIVRDLYSGAEL----AKIFSLLMMILAIAPALAPLL--------GGLLLLF----- 149
|
170 180 190
....*....|....*....|....*....|....*
gi 15218057 199 adLAWRLI---LMIGALPAALTFYWRmlMPETARY 230
Cdd:cd17320 150 --FGWRAIfvfLALLGLLLLLLVLLF--LPETLPE 180
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
49-218 |
3.52e-07 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 52.60 E-value: 3.52e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 49 VYYNGDSinTAVLSTSYAIALLGTATGQLVFGYLGDRVGRRRVYGLCLIIMILSSFGCGFSVCTTrrscvMVSLGFFRFF 128
Cdd:COG2211 256 KYVLGLS--AALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPGN-----LWLLLVLAAL 328
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 129 LGLGIGGDYPLSATIMSEFA-------NKRTRGAFiaavFSMQGLGILVSSAVTMAVcVAFKRSGGGLEVDAAAPTEAdl 201
Cdd:COG2211 329 AGIGLGAILVLPWAMLADVVdydewktGRRREGLY----FGIFTFAIKLGQALAGAL-AGLLLALFGYVAGAAQSPSA-- 401
|
170
....*....|....*..
gi 15218057 202 AWRLILMIGALPAALTF 218
Cdd:COG2211 402 LTGIRLLFFLLPAVLLL 418
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
65-232 |
4.04e-07 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 52.27 E-value: 4.04e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 65 YAIALLGTATGQLVFGYLGDRVGRRRVyglcLIIMILsSFGcGFSVCTTRRSCvMVSLGFFRFFLGLGIGGDYPLSATIM 144
Cdd:PRK11551 56 FSAGILGLLPGALLGGRLADRIGRKRI----LIVSVA-LFG-LFSLATAQAWD-FPSLLVARLLTGVGLGGALPNLIALT 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 145 SEFANKRTRGAFIAAVFSMQGLGILVSSAVTMAvcvafkrSGGglevdaaapteaDLAWRLILMIGAL-PAALTFYWRML 223
Cdd:PRK11551 129 SEAVGPRLRGTAVSLMYCGVPFGGALASVIGVL-------AAG------------DAAWRHIFYVGGVgPLLLVPLLMRW 189
|
....*....
gi 15218057 224 MPETARYTA 232
Cdd:PRK11551 190 LPESRAFAQ 198
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
35-178 |
4.27e-07 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 52.24 E-value: 4.27e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 35 DLFCIAPVMKMISHVYYNGDSI---NTAVLSTSYAIAllgtatgQLVFGYLGDRVGRRRVYGLCLIIMILSSFGCGFSVC 111
Cdd:cd17328 14 DRFTIAGVLPDIQSDFLIDDSLaglLQTVFIISYMVL-------SPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPN 86
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15218057 112 TTrrscvmvSLGFFRFFLGLGIGGDYPLSATIMSEFANKRTRGAFIaAVFSM-----QGLGILVSSAVTMAV 178
Cdd:cd17328 87 FW-------QLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRAL-GVFYFaiplgSGLGYVVGGLVAQAT 150
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
38-177 |
5.41e-07 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 51.81 E-value: 5.41e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 38 CIAPVMKMISHVYynGDSINTAVLSTSyaIALLGTATGQLVFGYLGDRVGRRRVYGLCLIIMILSSFGCGFSVcttrrsc 117
Cdd:cd17323 17 IYSPALPQIAEDF--HVSEEVANLGVS--LFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAP------- 85
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15218057 118 VMVSLGFFRFFLGLGIGGDYPLSATIMSEFANKRTRG----AFIAAVFSMQGLGILVSSAVTMA 177
Cdd:cd17323 86 NIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGkamgVYSLGPLLGPALGPIIGGFITQS 149
|
|
| xylE |
PRK10077 |
D-xylose transporter XylE; Provisional |
66-505 |
7.33e-07 |
|
D-xylose transporter XylE; Provisional
Pssm-ID: 182225 [Multi-domain] Cd Length: 479 Bit Score: 51.62 E-value: 7.33e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 66 AIALLGTATGQLVFGYLGDRVGRRRVYGLCLIIMILSSFGC-----GFSVCTTRRSCVMVSLGFFRFFLGLGIGGDYPLS 140
Cdd:PRK10077 62 ASALIGCIIGGALGGYCSNRFGRRDSLKIAAVLFFISALGSawpefGFTSIGPDNTGYVPEFVIYRIIGGIGVGLASMLS 141
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 141 ATIMSEFANKRTRGAFIAAVFSMQGLGILVssavtmAVCVAFKRSGGGlevdaAAPTEADLAWRLILMIGALPAALTFYW 220
Cdd:PRK10077 142 PMYIAEIAPAHIRGKLVSFNQFAIIFGQLV------VYFVNYFIARSG-----DASWLNTDGWRYMFASEAIPALLFLML 210
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 221 RMLMPETARYTALVeNNIVQAAKDMQRVMSrshiSDEATTDPPPPPPPPSYKlfsrcffRLHGRDLFAasfnwFLVDIVF 300
Cdd:PRK10077 211 LYFVPETPRYLMSR-GKQEQAEGILRKIMG----NTLATQALQEIKHSLDHG-------RKTGGKLLM-----FGVGVIV 273
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 301 ytSNLLLShIFS---------HYSkkPSTAENVyDAAFEVAELGAIIAACSTIPGYWFTVYFIDKIGRVKIQIMGFFFMA 371
Cdd:PRK10077 274 --IGVMLS-VFQqfvginvvlYYA--PEIFKTL-GASTDIALLQTIIVGVINLTFTVLAIMTVDKFGRKPLQIIGALGMA 347
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 372 VIYLVAGIPYSwywskheHNNKGFMVLYGLVFFFCNF----GPntTTFIIPAEHFPARFRstchgisgaaGKLGAIvgTV 447
Cdd:PRK10077 348 IGMFSLGTAFY-------TQAPGIVALLSMLFYVAAFamswGP--VCWVLLSEIFPNAIR----------GKALAI--AV 406
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15218057 448 GFLWATKKMESD-----DKNQIYPEVNRMRIAFLILGGVCIAGILVTYFFTKETMGRSLEENE 505
Cdd:PRK10077 407 AAQWIANYFVSWtfpmmDKNSWLVAHFHNGFSYWIYGCMGVLAALFMWKFVPETKGKTLEEME 469
|
|
| MFS_SV2C |
cd17440 |
Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; ... |
24-230 |
9.65e-07 |
|
Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2C exhibits enriched expression in several basal ganglia nuclei, and has been found to be involved in normal operation of the basal ganglia network and could be also be involved in system adaptation in basal ganglia pathological conditions. SV2C belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340998 [Multi-domain] Cd Length: 479 Bit Score: 51.45 E-value: 9.65e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 24 VAGMGLFTDAYDLFCIAPVMKMISHVYYNGDSINTAVLSTSYaialLGTATGQLVFGYLGDRVGRRRVYGLCLII----M 99
Cdd:cd17440 3 VLGMALMADGVEVFVVGFVLPSAETDMCIPNSGSGWLGSIVY----LGMMVGAFFWGGLADKVGRRQSLLICMSVngffA 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 100 ILSSFGCGFsvcttrrscvmvslGFF---RFFLGLGIGGDYPLSATIMSEFANKRTRGAFIAAVFSMQGLGILVSSAVTM 176
Cdd:cd17440 79 FLSSFVQGY--------------GLFlfcRLLSGFGIGGAVPTVFSYFAEVLAREKRGEHLSWLCMFWMIGGIYASAMAW 144
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 15218057 177 AVCVAFkrsGGGLEVDAAAPTEadlAWRLILMIGALPAALTFYWRMLMPETARY 230
Cdd:cd17440 145 AIIPHY---GWSFSMGSAYQFH---SWRVFVIVCALPCVSSVVALTFMPESPRF 192
|
|
| MFS_GLUT_Class1 |
cd17431 |
Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ... |
21-247 |
1.72e-06 |
|
Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-4 are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT1, also called solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1), displays broad substrate specificity and can transport a wide range of pentoses and hexoses including glucose, galactose, mannose, and glucosamine. It is found in the brain, erythrocytes, and in many fetal tissues. GLUT2 (or SLC2A2) is found in the liver, islet of Langerhans, intestine, and kidney, and is the isoform that likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by beta cells. GLUT3 (or SLC2A3) is found in the brain and can mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and dehydroascorbate. GLUT4 (or SLC2A4) is an insulin-regulated facilitative glucose transporter found in adipose tissues, and in skeletal and cardiac muscle. GLUT14 (or SLC2A14) is an orphan transporter expressed mainly in the testis. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340989 [Multi-domain] Cd Length: 445 Bit Score: 50.41 E-value: 1.72e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 21 AIIVAGMGLFTDAYDLFCIAPVMKMI------SHVYYNGDSIN----TAVLSTSYAIALLGTATGQLVFGYLGDRVGRRR 90
Cdd:cd17431 2 AVFVAVLGSLQFGYNTGVINAPQKVIeefynkTLGDRYGEPISpetlTTLWSLSVAIFSVGGMIGSFSVGLFVNRFGRRN 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 91 VYGLCLIIMILSSFGCGFSVCTTrrSCVMVSLGffRFFLGLGIGGDYPLSATIMSEFANKRTRGAF-----IAAVfsmqg 165
Cdd:cd17431 82 SMLYNNLLAFAGAALMGLSKLAK--SYEMLILG--RFIIGLYCGLTTGLVPMYIGEISPTALRGALgtlhqLGIV----- 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 166 LGILVSSAVtmavcvafkrsggGLEVDAAAPTeadlAWRLILMIGALPAALTFYWRMLMPETARYTALVENNIVQAAKDM 245
Cdd:cd17431 153 VGILISQIF-------------GLEFILGTEE----LWPLLLGFTIVPAILQLALLPFCPESPRYLLINRNEEEEAKSVL 215
|
..
gi 15218057 246 QR 247
Cdd:cd17431 216 KK 217
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
39-229 |
3.75e-06 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 49.11 E-value: 3.75e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 39 IAPVMKMISHVYYNGDSINTAVLSTSYAialLGTATGQLVFGYLGDRVGRRRVYGLCLIIMILSSFGCGFsvcTTRRSCV 118
Cdd:cd17473 18 IAPALPAIAQHFVPNSELLVPLLLTLPA---LFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLF---LDSLYAL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 119 MVSlgffRFFLGLGIGGDYPLSATIMSEFANKRTRGAFIAAVFSMQGLGILVSSAVtmavcvafkrsGGGLevdaaapte 198
Cdd:cd17473 92 LAS----RALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLL-----------GGAL--------- 147
|
170 180 190
....*....|....*....|....*....|...
gi 15218057 199 ADLAWRLILMI--GALPAALTFYWrmLMPETAR 229
Cdd:cd17473 148 AEIGWRAPFLVylLALPVLILVLL--FLPEPAR 178
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
61-174 |
4.86e-06 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 48.73 E-value: 4.86e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 61 LSTSYAIALlgtATGQLVFGYLGDRVGRRRVYGLCLIIMILSSFGCGFSvcTTrrscvMVSLGFFRFFLGLGIGGDYPLS 140
Cdd:cd17503 36 VITSYLLAL---AIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLA--PN-----LASLIIFRILQGFGGGVLIPLA 105
|
90 100 110
....*....|....*....|....*....|....
gi 15218057 141 ATIMSEFANKRTRGAFIAAVfsmqGLGILVSSAV 174
Cdd:cd17503 106 QTILLRIYPPEKRGAAMGLV----GLVILLAPAI 135
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
63-170 |
8.79e-06 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 47.94 E-value: 8.79e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 63 TSYAIALlgtATGQLVFGYLGDRVGRRRVYGLCLIIMILSSFGCGFSVCTTrrscvmvSLGFFRFFLGLGIGGDYPLSAT 142
Cdd:cd17321 38 NAYLLAF---AALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLA-------FLIAARALQGIGAAAIMPASLA 107
|
90 100
....*....|....*....|....*...
gi 15218057 143 IMSEFANKRTRGAFIAAVFSMQGLGILV 170
Cdd:cd17321 108 LIAATFPGERRGRALGLWGAVVGIGAAL 135
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
56-174 |
1.10e-05 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 47.57 E-value: 1.10e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 56 INTAVLSTSYAIALLGTATGQLVFGYLGDRVGRRRVYGLCLIIMILSSFGCGFSVCttrrscvMVSLGFFRFFLGLGIGG 135
Cdd:cd17325 232 LSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATS-------FWLLLLLLALLGLGLGL 304
|
90 100 110
....*....|....*....|....*....|....*....
gi 15218057 136 DYPLSATIMSEFANKRTRGAFIAAVFSMQGLGILVSSAV 174
Cdd:cd17325 305 VFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLL 343
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
66-178 |
1.10e-05 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 47.55 E-value: 1.10e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 66 AIALLGTATGQLVFGYLGDRVGRRRVYGLCLIIMILSSFGCGFSVCTTrrscvmVSLGFFRFFLGLGIGGDYPLSATIMS 145
Cdd:cd17477 230 AAFVLGGLLLQWPLGWLADRFDRRRVLLGCALLGALAALLLPLVPGLP------LALLVLLFLWGGAAGPLYTLALALAG 303
|
90 100 110
....*....|....*....|....*....|...
gi 15218057 146 EFANKRTRGAFIAAVFSMQGLGILVSSAVTMAV 178
Cdd:cd17477 304 DRLPGDELVAANAALLLLYGLGSVIGPLLAGAL 336
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
69-218 |
1.51e-05 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 47.19 E-value: 1.51e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 69 LLGTATGQLVFGYLGDRVGRRRVYGLCLIIMILSSFGCGFSVCTTrrscvmvSLGFFRFFLGLGiGGDYPLSATIMSE-F 147
Cdd:cd17504 41 LLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLP-------VLIAGRALQGIG-GAVFPLAFALVREeF 112
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15218057 148 ANKRTRGAfiaavfsmqgLGILVSSAVTmavcvafkrsGGGLEVDAAAPTEADLAWRLILMIGALPAALTF 218
Cdd:cd17504 113 PPERVPVA----------QGILSATFGI----------GAGIGLPLGGWIVQHLGWRWIFWTAAPVAVLLA 163
|
|
| PRK10642 |
PRK10642 |
proline/glycine betaine transporter ProP; |
1-236 |
1.79e-05 |
|
proline/glycine betaine transporter ProP;
Pssm-ID: 182611 [Multi-domain] Cd Length: 490 Bit Score: 47.40 E-value: 1.79e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 1 MPIKVLSSLDVARTQwyhfKAIIVAGMGLFTDAYDLFCIAPVMKMISHVYYNGDSINT---AVLSTsYAIALLGTATGQL 77
Cdd:PRK10642 1 ITLRDVTIIDDGKLR----KAITAASLGNAMEWFDFGVYGFVAYALGKVFFPGADPSVqmiAALAT-FSVPFLIRPLGGL 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 78 VFGYLGDRVGRRRVYGLCLIIMILSSFGCGF-SVCTTRRSCVMVSLGFFRFFLGLGIGGDYPLSATIMSEFANKRTRGAF 156
Cdd:PRK10642 76 FFGMLGDKYGRQKILAITIVIMSISTFCIGLiPSYATIGIWAPILLLLCKMAQGFSVGGEYTGASIFVAEYSPDRKRGFM 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 157 --------IAAVFSMQGLGILVSSAVTMAvcvAFkrsggglevdaaapteADLAWRLILMIgALPAALT-FYWRMLMPET 227
Cdd:PRK10642 156 gswldfgsIAGFVLGAGVVVLISTIVGEA---NF----------------LDWGWRIPFFI-ALPLGIIgLYLRHALEET 215
|
....*....
gi 15218057 228 ARYTALVEN 236
Cdd:PRK10642 216 PAFQQHVDK 224
|
|
| PRK12307 |
PRK12307 |
MFS transporter; |
50-138 |
2.16e-05 |
|
MFS transporter;
Pssm-ID: 237051 [Multi-domain] Cd Length: 426 Bit Score: 46.85 E-value: 2.16e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 50 YYNGDSINTAVLSTSYAIALLGTATGQLVFGYLGDRVGRRRVYGLCLIIMILssFGCGFSVCTTRRSCVMVSLGFFRFFL 129
Cdd:PRK12307 257 YLAGEGFDTGVVSNLMTAAAFGTVLGNIVWGLCADRIGLKKTFSIGLLMSFL--FIFPLFRIPQDNYLLLGACLFGLMAT 334
|
....*....
gi 15218057 130 GLGIGGDYP 138
Cdd:PRK12307 335 NVGVGGLVP 343
|
|
| MFS_STP |
cd17361 |
Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; ... |
58-495 |
3.71e-05 |
|
Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; The plant Sugar transport protein (STP) subfamily includes STP1-STP14; they are also called hexose transporters. They mediate the active uptake of hexoses such as glucose, 3-O-methylglucose, fructose, xylose, mannose, galactose, fucose, 2-deoxyglucose and arabinose, by sugar/hydrogen symport. Several STP family transporters are expressed in a tissue-specific manner, or at specific developmental stages. STP1 is the member with the highest expression level of all members and high expression is detected in photosynthetic tissues, such as leaves and stems, while roots, siliques, and flowers show lower expression levels. It plays a major role in the uptake and response of Arabidopsis seeds and seedlings to sugars. The STP subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340919 [Multi-domain] Cd Length: 390 Bit Score: 46.09 E-value: 3.71e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 58 TAVLSTSYAIALLGTatgqLVFGYLGDRVGRRRVYGLCLIIMILssfGCGFSVCTTRRSCVMVSlgffRFFLGLGIGGDY 137
Cdd:cd17361 54 QLFTSSLYLAGLVAS----LLASYVTRKWGRKPSMLIGGVLFLV---GAALNAAAQNIAMLIVG----RILLGFGVGFGN 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 138 PLSATIMSEFANKRTRGAFIAAVFSMQGLGILVSSAVTMAVcvafkrsggglevdaaaPTEADLAWRLILMIGALPAALT 217
Cdd:cd17361 123 QAVPLYLSEMAPAKLRGALNIGFQLAITIGILIANLINYGT-----------------SKIKPNGWRLSLGLAAVPALIL 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 218 FYWRMLMPETARYTALVENNIVQAakdmqrvmsrshisdeattdppppppppsyklfsrcFFRLHGRDLfaasfnwflvd 297
Cdd:cd17361 186 LLGSLFLPETPNSPQLVIAILIPF------------------------------------FQQLTGINV----------- 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 298 IVFYTSNLLLSHIFSHyskkpstaenvyDAAFevaeLGAIIAACSTIPGYWFTVYFIDKIGRVKIQIMGFFFMAVIYLVA 377
Cdd:cd17361 219 IMFYAPVLFQTLGFGS------------DASL----ISAVITGAVNVVSTLVSIYLVDRFGRRFLLLEGGVQMLASQVAI 282
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 378 GIPYSWYWSKHEHNNKGfmVLYGLVFFFC------NFGPNTTTFIIPAEHFPARFRSTCHGISGAAGKLGAIVGTVGFLW 451
Cdd:cd17361 283 GILLAVKFGDGGELPKA--YAIAVVVLIClyvaafAWSWGPLGWLVPSEIFPLETRSAGQSLTVAVNFLFTFVIAQAFLS 360
|
410 420 430 440
....*....|....*....|....*....|....*....|....
gi 15218057 452 ATKKMESDdknqiypevnrmriAFLILGGVCIAGILVTYFFTKE 495
Cdd:cd17361 361 MLCAMKFG--------------IFLFFAGWVVVMSLFVYFLLPE 390
|
|
| MFS_CitA |
cd17368 |
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ... |
22-227 |
4.78e-05 |
|
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340926 [Multi-domain] Cd Length: 407 Bit Score: 45.83 E-value: 4.78e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 22 IIVAGMGLFTDAYDLFCIAPVMKMISHVYYNGDSINTAVLSTsyaIALLGTA-----TGQLVFGYLGDRVGRRRVYGLCL 96
Cdd:cd17368 1 ILAATSGNALEFFDFGVYGFFAVYIGRLFFPSGSEFASLLLT---FATFGVGffmrpIGAIVLGAYADRIGRKPAMTLTL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 97 IIMILSSFGCGFsvCTTRRSC-----VMVSLGffRFFLGLGIGGDYPLSATIMSEFANKRTRGAFIAAVFSMQGLGILVS 171
Cdd:cd17368 78 AIMALGTLLIAL--APTYATIgiaapLLVLLA--RLLQGFAAGGEVGGVTAYLVEAAPPGRRGFYTSWQSASQQVAIVAG 153
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 15218057 172 SAVtmavcvafkrsGGGLEVDAAAPTEADLAWRLILMIGALPAALTFYWRMLMPET 227
Cdd:cd17368 154 ALV-----------GYLLSLTLTAEALAEWGWRIPFFIGLLIIPLGLWLRRSLEET 198
|
|
| MFS_SLC22A17 |
cd17445 |
Solute carrier family 22, member 17 of the Major Facilitator Superfamily; Solute carrier ... |
69-137 |
5.82e-05 |
|
Solute carrier family 22, member 17 of the Major Facilitator Superfamily; Solute carrier family 22, member 17 (SLC22A17) is also called 24p3 receptor (24p3R), lipocalin-2 receptor, or neutrophil gelatinase-associated lipocalin (NGAL) receptor (NGALR). It functions as a cell surface receptor for lipocalin-2 (LCN2), also called NGAL or 24p3, which plays a key role in iron homeostasis and transport. LCN2 is a secreted protein of the lipocalin family that induces apoptosis in some types of cells and inhibits bacterial growth by sequestration of the iron-laden bacterial siderophore. Over-expressions of NGAL and NGALR have been found to be correlated with unfavorable clinicopathologic features and poor prognosis of patients with hepatocellular carcinoma. SLC22A17 is a member of the SLC22 family of organic cation/anion/zwitterion transporters, which includes organic cation transporters (OCTs/OCTNs) and organic anion transporters (OATs). It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341003 [Multi-domain] Cd Length: 346 Bit Score: 45.54 E-value: 5.82e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15218057 69 LLGTATGQLVFGYLGDRVGRRRVYGLCLIIMILssfgCGFSVCTTRRSCVMVSLgffRFFLGLGIGGDY 137
Cdd:cd17445 46 ILGFASGYLCLGYTADRLGRRRTLLLSLTLAVP----FGVLVAVAASPSLFMAM---RFLLGAALAGVY 107
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
65-174 |
6.00e-05 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 45.23 E-value: 6.00e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 65 YAIALLGTATGQLVFGYLGDRVGRRRVYGLCLIIMILSSFGCGFSVcttrrSCVMVSLGFfrFFLGLGIGGDYPLSATIM 144
Cdd:cd17370 240 YALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGS-----SLWLLLLGF--ILWGLYMGAQESIERAAV 312
|
90 100 110
....*....|....*....|....*....|
gi 15218057 145 SEFANKRTRGAFIAAVFSMQGLGILVSSAV 174
Cdd:cd17370 313 ADLVPAELRGTAYGLFNTVVGIGWLLASLI 342
|
|
| PRK12307 |
PRK12307 |
MFS transporter; |
20-453 |
8.34e-05 |
|
MFS transporter;
Pssm-ID: 237051 [Multi-domain] Cd Length: 426 Bit Score: 44.92 E-value: 8.34e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 20 KAIIVAGMGLFTDAYDLFCIAPVMKMISHVYYNGDsINTAVLSTsyaIALLGTATGQLVFGYLGDRVGRRRvygLCLIIM 99
Cdd:PRK12307 18 NALFSAWLGYVFDGFDFMLIFYIMYLIKADLGLTD-MEGAFLAT---AAFIGRPFGGALFGLLADKFGRKP---LMMWSI 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 100 ILSSFGCGFSVCTTRrscvMVSLGFFRFFLGLGIGGDYPLSATIMSEFANKRTRGAFIAAVFSMQGLGILVSSAVTMAVC 179
Cdd:PRK12307 91 VAYSVGTGLSGLASG----VIMLTLSRFIVGMGMAGEYACASTYAVESWPKHLKSKASAFLVSGFGIGNIIAAYFMPSFA 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 180 VAFkrsggglevdaaapteadlAWRLILMIGALPAALTFYWRMLMPETARYtalvennivqaakdmqrvmsrshisDEAT 259
Cdd:PRK12307 167 EAY-------------------GWRAAFFVGLLPVLLVIYIRARAPESKEW-------------------------EEAK 202
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 260 TDPPPPPPPPSYKLFSRCFFRLHGRDLFAASFNWFLVDIVFYTSNLLLSHIFSHYskkpsTAENVYDAAfeVAELGAIIA 339
Cdd:PRK12307 203 LSGKGKHSQSAWSVFSLSMKGLFNRAQFPLTLCVFIVLFSIFGANWPIFGLLPTY-----LAGEGFDTG--VVSNLMTAA 275
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 340 ACSTIPGYWFTVYFIDKIGRVKI----QIMGFFFMAVIYLVAGIPYSWYWskhehnnkgfMVLYGLVFFFCNFGPNTTTF 415
Cdd:PRK12307 276 AFGTVLGNIVWGLCADRIGLKKTfsigLLMSFLFIFPLFRIPQDNYLLLG----------ACLFGLMATNVGVGGLVPKF 345
|
410 420 430
....*....|....*....|....*....|....*...
gi 15218057 416 IIpaEHFPARFRSTChgiSGAAGKLGAIVGTVGFLWAT 453
Cdd:PRK12307 346 LY--DYFPLEVRGLG---TGLIYNLAATSGTFNSMAAT 378
|
|
| MFS_PLT |
cd17437 |
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The ... |
67-503 |
8.48e-05 |
|
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The plant Polyol transporter (PLT) subfamily includes PLT1-6 from Arabidopsis thaliana and similar transporters. The best characterized member of the group is Polyol transporter 5, also called Sugar-proton symporter PLT5, which mediates the H+-symport of numerous substrates including linear polyols (such as sorbitol, xylitol, erythritol or glycerol), cyclic polyol myo-inositol, and different hexoses, pentoses (including ribose), tetroses, and sugar alcohols. It functions to transport a wide range of substrates into specific sink tissues in the plant. The PLT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340995 [Multi-domain] Cd Length: 387 Bit Score: 45.08 E-value: 8.48e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 67 IALLGTATGqlvfGYLGDRVGRRRVYGLCLIIMILSSFGCGFSvctTRRSCVMVSlgffRFFLGLGIGGDYPLSATIMSE 146
Cdd:cd17437 44 ISLVGSLAA----GRTSDWIGRRYTIALAALIFFVGALLMGVA---PNYPVLMVG----RFVAGIGVGFALMIAPVYTAE 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 147 FANKRTRGAFIAAVFSMQGLGILVSSAVTMAVcvafkrsgGGLEVDaaapteadLAWRLILMIGALPAALTFYWRMLMPE 226
Cdd:cd17437 113 VAPASSRGFLTSFPEIFINIGILLGYVSNYAF--------SGLPLH--------VGWRLMLGVGAVPSLFLAIGVLAMPE 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 227 TARYTALVENNIVQAakdmqrvmsrshisdeattdppppppppsykLFSRCFFRLHGrdlfaasfnwflVDIVFYTSnll 306
Cdd:cd17437 177 SPRWTPAVRRMLIAA-------------------------------LGIHFFQQASG------------IDAVVLYS--- 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 307 lSHIFSHYSKKPSTAEnvydaafevaeLGAIIAACSTIPGYWFTVYF-IDKIGRVKIQIMGFFFMAVIYLVAGIPYSWYw 385
Cdd:cd17437 211 -PRIFKKAGIKSKDKL-----------LLATVAVGVTKTLFILVATFlLDKVGRRPLLLTSTGGMTLSLTALATSLTFI- 277
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 386 skhehNNKGFMVLYGLV-----------FFFCNFGPntTTFIIPAEHFPARFRSTCHGISGAAGKLGAIVGTVGFLWATK 454
Cdd:cd17437 278 -----DRNGGGLTWALVlaitavcsfvaFFSIGAGP--ITWVYSSEIFPLRLRAQGASLGVVVNRLMSGTVSMTFLSMSK 350
|
410 420 430 440
....*....|....*....|....*....|....*....|....*....
gi 15218057 455 KMESDDknqiypevnrmriAFLILGGVCIAGILVTYFFTKETMGRSLEE 503
Cdd:cd17437 351 AITTGG-------------TFFLFAGVAAAAWVFFYFFLPETKGKSLEE 386
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
49-187 |
9.77e-05 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 44.51 E-value: 9.77e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 49 VYYNGDSINTAVLSTSYAIALLGTATGQLVFGYLGDRVGRRRVYGLCLIIMILSSFGCGFSVCTTrrscvMVSLGFFRFF 128
Cdd:cd17316 203 YLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLLSGS-----PTLLLLLLFI 277
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 15218057 129 LGLGIGGDYPLSATIMSEFANKRTRGAFIAAVFSmqgLGILVSSAVTMAVCVAFKRSGG 187
Cdd:cd17316 278 LSFFVGGVWGALYAYLAELFPTEVRATGVGLSYN---LGRLGGGGAPPLIALLLASTGG 333
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
21-218 |
1.01e-04 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 44.86 E-value: 1.01e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 21 AIIVAGMGLftdAYDLFCIAPVMKMISHVYyngdSINTAVLSTSYAIALLGTATGQLVFGYLGDRVGRRRVYGLCLIIMI 100
Cdd:COG2807 22 AIVLVALNL---RPAITSVGPLLPEIRADL----GLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLA 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 101 LSSFGcgfsvcttrRSCVMVSLGFF--RFFLGLGIG-GDYPLSATIMSEFANKrtRGAFIAAVFSMQGLGILVSSAVTma 177
Cdd:COG2807 95 AGLLL---------RSLAPSVALLLagTALIGAGIAvGNVLLPGLIKRWFPDR--VGLMTGLYTAAMGLGAALAAGLT-- 161
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 15218057 178 vcvafkrsggglevdaaAPTEADLAWRLILMIGALPAALTF 218
Cdd:COG2807 162 -----------------VPLAAALGWRGALAVWALLALLAL 185
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
56-170 |
1.05e-04 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 44.54 E-value: 1.05e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 56 INTAVLSTSYAIALLGTATGQLVFGYLGDRVG---RRRVYGLCLIIMILSSFGcgFSVCTtrRSCVMVSLGFFRFFLGLG 132
Cdd:cd17475 231 LSVVAAGALLAVAQLGGALGRIGLGRVSDRVFggrRRPVLVITAAIAAAALLV--LSLLS--PGTPLWLLVLLLILLGLF 306
|
90 100 110
....*....|....*....|....*....|....*...
gi 15218057 133 IGGDYPLSATIMSEFANKRTRGAFIAAVFSMQGLGILV 170
Cdd:cd17475 307 AIGWNGLYLTLVAESAGPEQAGTALGLANTINFIGIAI 344
|
|
| MFS_SVOP |
cd17441 |
Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic ... |
23-230 |
1.38e-04 |
|
Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein (SVOP) is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. This SVOP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340999 [Multi-domain] Cd Length: 372 Bit Score: 44.42 E-value: 1.38e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 23 IVAGMGLFTDAYD---LFCIAPVMkmisHVYYNGDSINTAVLSTSYAIALLGTATgqlVFGYLGDRVGRR---RVYGLCL 96
Cdd:cd17441 2 ILTGLAWMADAMEmmiLSILAPQL----HCEWRLPSWQVALLTSVVFIGMMLSSS---LWGNISDQYGRKtglKISVLWT 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 97 IIM-ILSSFGCGFSVcttrrscvmvsLGFFRFFLGLGIGGdYPLSATIMSEFANKRTRGAFIAAVFSMQGLGILVSsaVT 175
Cdd:cd17441 75 LYYgILSAFAPIYSW-----------ILVLRGLVGFGIGG-VPQSVTLYAEFLPMKSRAKCILLIEVFWALGTVFE--VL 140
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 15218057 176 MAVCVafkrsggglevdaaAPTeadLAWRLILMIGALPAALTFYWRMLMPETARY 230
Cdd:cd17441 141 LAVFV--------------MPT---LGWRWLLILSALPLLIFAVLCFWLPESARY 178
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
69-238 |
1.82e-04 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 43.91 E-value: 1.82e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 69 LLGTATGQLVFGYLGDRVGRRRVYGLCLIIMILSSFGCGFSVCTTrrscvmvSLGFFRFFLGLGIGGDYPLSATIMSEFA 148
Cdd:TIGR00710 50 LLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSLGLALSNNIE-------TLLVLRFVQAFGASAGSVISQALVRDIY 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 149 NKRTRGAFIAAVFSMQGLGILVSSAVtmavcvafkrsgGGLEVDAaapteadLAWRLI---LMIGALPAALTFYWrmLMP 225
Cdd:TIGR00710 123 PGEELSRIYSILMPVLALAPAVAPLL------------GGYILVW-------LSWHAIfafLSLAGILLSALIFF--ILP 181
|
170
....*....|...
gi 15218057 226 ETARYTALVENNI 238
Cdd:TIGR00710 182 ETLPYEARIQIST 194
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
56-174 |
4.19e-04 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 42.56 E-value: 4.19e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 56 INTAVLSTSYAIALLGTATGQLVFGYLGDRVGRRRVYGLCLIIMILSSFGCGFSVCTTrrscvmvSLGFFRFFLGLGIGG 135
Cdd:cd17319 35 LSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLT-------SLYVLRFLLGVAEAG 107
|
90 100 110
....*....|....*....|....*....|....*....
gi 15218057 136 DYPLSATIMSEFANKRTRGAFIAAVFSMQGLGILVSSAV 174
Cdd:cd17319 108 FFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPL 146
|
|
| MFS_SVOP_like |
cd17372 |
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ... |
23-444 |
5.29e-04 |
|
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340930 [Multi-domain] Cd Length: 367 Bit Score: 42.52 E-value: 5.29e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 23 IVAGMGLFTDAYDLFCIAPVMKMIsHVYYNGDSINTAVLSTsyaIALLGTATGQLVFGYLGDRVGRRRVyglcLIIMILS 102
Cdd:cd17372 2 AYAGMGWVAEAMEMMLLSFVGPAV-QCEWNLSAWQVALITS---VVFAGMMIGSYLWGIVSDKYGRRKG----LIISALW 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 103 SFGCGFsvcTTRRSCVMVSLGFFRFFLGLGIGGdYPLSATIMSEFANKRTRGAFiaavfsmqglgilvssavtMAVCVAF 182
Cdd:cd17372 74 TFYAGF---LSAFAPNYMWLIILRCLVGLGLGG-GPQLASWYLEFLPAKSRGTW-------------------MVLFSVF 130
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 183 KRSGGGLEVDAAAPTEADLAWRLILMIGALPAALTFYWRMLMPETARYTALVennivqaakdmqrvmsrshisdeattdp 262
Cdd:cd17372 131 WTVGTIFEASLAWLVMPRLGWRWLLAFSSVPSSLLLVFYRWTPKTTLLLWVI---------------------------- 182
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 263 pppppppsyklfsrcffrlhgrdLFAASFNWFLVdiVFYTSNLLLSHIFSHYSKKPSTAENVYDAAF----EVAELGAII 338
Cdd:cd17372 183 -----------------------WFGNAFAYYGV--VLLTTELNNSHNVCGSKSDSDSGESPTEKQCrnsnDVDYRDVFI 237
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 339 AACSTIPGYWFTVYFIDKIGRVKIQIMGFFFMAVIYLVAGIpyswywskHEHNNKGFMVLYGL-VFFFCNFgpnTTTFII 417
Cdd:cd17372 238 ATFAEFPGLLISAAMIDRLGRKASMASMLFTCCIFLLLLLI--------CQSPFILTVLLFGGrACISAAF---TVVYIY 306
|
410 420
....*....|....*....|....*..
gi 15218057 418 PAEHFPARFRSTCHGISGAAGKLGAIV 444
Cdd:cd17372 307 TPEVYPTAVRALGVGTGSSVGRIGAIL 333
|
|
| MFS_SLC22A1_2_3 |
cd17379 |
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, ... |
70-178 |
5.56e-04 |
|
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, and 3) of the Major Facilitator Superfamily of transporters; This sufamily includes solute carrier family 22 member 1 (SLC22A1, also called organic cation transporter 1 or OCT1), SLC22A2 (or OCT2), SLC22A3 (or OCT3), and similar proteins. OCT1-3 have similar basic functional properties: they are able to translocate a variety of structurally different organic cations in both directions across the plasma membrane; to translocate organic cations independently from sodium, chloride or proton gradients; and to function as electrogenic uniporters for cations or as electroneutral cation exchangers. They show overlapping but distinct substrate and inhibitor specificities, and different tissue expression pattern. In humans, OCT1 is strongly expressed in the liver, OCT2 is highly expressed in the kidney where it is localized at the basolateral membrane of renal proximal tubules, and OCT3 is most strongly expressed in skeletal muscle. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. The SLC22A1-3 subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340937 [Multi-domain] Cd Length: 340 Bit Score: 42.34 E-value: 5.56e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 70 LGTATGQLVFGYLGDRVGRRrvygLCLIIMILSSFGCGFSVCTTRRSCVMVslgFFRFFLGLGIGGDYPLSATIMSEFA- 148
Cdd:cd17379 44 LGFLIGSIVIGYLADRFGRK----VCFLISILGNGVSGVLMAFSPNYPWFL---IFRFLQGLFGKGGWMTGYVLVTEFVg 116
|
90 100 110
....*....|....*....|....*....|..
gi 15218057 149 --NKRTRGAFIAAVFSmqgLGILVSSAVTMAV 178
Cdd:cd17379 117 skYRRTVGIVYQMFFT---LGLLILPGIAYFI 145
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
60-171 |
6.30e-04 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 42.16 E-value: 6.30e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 60 VLSTSYAIALLgtaTGQLVFGYLGDRVGRRRVYGLCLIIMILSSFGCGFSVcttrrscVMVSLGFFRFFLGLGIGGDYPL 139
Cdd:cd17477 35 LVASAYYLGIL---LGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTD-------SPWVWFLLRFVMGIGLAGLFVV 104
|
90 100 110
....*....|....*....|....*....|..
gi 15218057 140 SATIMSEFANKRTRGAFIAAVFSMQGLGILVS 171
Cdd:cd17477 105 SESWLNALATNENRGRVLGLYSTVLGLGFALG 136
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
66-218 |
7.77e-04 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 41.85 E-value: 7.77e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 66 AIALLGTATGQLVFGYLGDRVGRRRVYGLCLIIMILSSFGCGFSVCTtrrscvMVSLGFFRFFLGLGiGGDYPLSATIMS 145
Cdd:cd17341 41 AIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIPLLALALAVSS------YWGLLVLGFLLGFA-GANFASGQPWAS 113
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15218057 146 EFANKRTRGAFIAAVFSMQGLGILVSSAVTMAVCVAFKRSGGGlevdaaapteadLAWRLILMIGALPAALTF 218
Cdd:cd17341 114 FWFPKEKIGGAAGGIAGAGNMGVAVSQLLAPLIAGAIVFDGGF------------VGWRNAFFVPGILLAIAA 174
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
40-257 |
9.03e-04 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 41.85 E-value: 9.03e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 40 APVMKMISHVYYNGDSINTAVlstsyAIALLGTATGQLVFGYLGDRVGRRRVygLCLIIMILSSFGCGFSVCTTRRSCVM 119
Cdd:cd17327 27 AAVMGMKEDLKLVGNQYNWGN-----TVFYVGYIIFELPGNLLLQRFPPSKW--LSVFIVLWGLLTLLTAAVKNFGGLIA 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 120 VslgffRFFLGLGIGGDYPLSATIMSEFANKRTRGAFIAAVFSMQGLGILVSSAVTMAVcvaFKRSG-GGLEvdaaapte 198
Cdd:cd17327 100 L-----RFFLGLFESGVFPGFILYLGMWYKREEQAKRIAFFYAAAGLGSIFGGLLAYGV---FKILGvGGLA-------- 163
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15218057 199 adlAWRLILMIGAL----PAALTFYWRMLMPETARYtaLVENNIVQAAKDMQRvMSRSHISDE 257
Cdd:cd17327 164 ---GWRWLFIIEGLitiiIGLVIFFWLPDNPSKAWF--LTEEEKELAVERLRA-NQTGKGDQK 220
|
|
| OATP |
pfam03137 |
Organic Anion Transporter Polypeptide (OATP) family; This family consists of several ... |
36-170 |
9.56e-04 |
|
Organic Anion Transporter Polypeptide (OATP) family; This family consists of several eukaryotic Organic-Anion-Transporting Polypeptides (OATPs). Several have been identified mostly in human and rat. Different OATPs vary in tissue distribution and substrate specificity. Since the numbering of different OATPs in particular species was based originally on the order of discovery, similarly numbered OATPs in humans and rats did not necessarily correspond in function, tissue distribution and substrate specificity (in spite of the name, some OATPs also transport organic cations and neutral molecules). Thus, Tamai et al. initiated the current scheme of using digits for rat OATPs and letters for human ones. Prostaglandin transporter (PGT) proteins are also considered to be OATP family members. In addition, the methotrexate transporter OATK is closely related to OATPs. This family also includes several predicted proteins from Caenorhabditis elegans and Drosophila melanogaster. This similarity was not previously noted. Note: Members of this family are described (in the Swiss-Prot database) as belonging to the SLC21 family of transporters.
Pssm-ID: 460821 [Multi-domain] Cd Length: 526 Bit Score: 41.80 E-value: 9.56e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 36 LFCIAPVMKMISHVYYNG-----------DSINTAVLSTSYAIALLGTAtgqLVFGYLGDRVGRRRVYGLCLIIMILSSF 104
Cdd:pfam03137 5 FLSLLGLAQALVSGYFNSsittiekrfglPSSLSGLISSSYDIGNLLLI---VFVSYFGGKGHRPRWIGVGALLMGLGSL 81
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15218057 105 gcgfsvcttrrscVMVSLGFFRFFLG---LGIGGD--YPLSATIMSEFANKRTRGAFIAAVFSMQGLGILV 170
Cdd:pfam03137 82 -------------LFALPHFLSFFLGqllLGIGGTpiYTLGISYIDDNVKKKNSPLYLGILYAVRVLGPAL 139
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
70-154 |
9.91e-04 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 41.45 E-value: 9.91e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 70 LGTATGQLVFGYLGDRVGRRRVYGLCLIIMILSSFGCGFSVcttrrSCVMVSLGFfrFFLGLGIGGDYPLSATIMSEFAN 149
Cdd:cd17475 42 LGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVG-----SYPVLLVLL--FLVGAGYGSVQPGGGRAIMRWFP 114
|
....*
gi 15218057 150 KRTRG 154
Cdd:cd17475 115 PRERG 119
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
58-187 |
1.56e-03 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 40.97 E-value: 1.56e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 58 TAVLSTSYAIALLGTATGQLV-------FGYLGDRVGRRRVYGLCLIIMILSSFGcGFSVCTTRRSCVMVSLGFFRFFLG 130
Cdd:cd17369 256 TQTLGVDRSTVLLAVLIASVVaaitiplFGWLSDRVGRRPVYLAGALLAALFAFP-FFWLLDTGSTWLIVLAAVVVLGVL 334
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 15218057 131 LGIGgdYPLSATIMSEFANKRTRgaFIAAVFSMQGLGILVSSAVTMAVCVAFKRSGG 187
Cdd:cd17369 335 HGMM--YGPQAAFLAELFPTRVR--YTGASLGYQLGAILGGGFAPLIATALVAATGS 387
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
61-178 |
1.59e-03 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 41.02 E-value: 1.59e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 61 LSTSYAIAL--LGTATGQLVFGYLGDRVGRRRVYGLCLIIMilssfGCGFSVCTTRRSCVMVSLGFfrFFLGLGIGGDYP 138
Cdd:cd17473 233 ALIGLALAIasLAGAIGALLFGRLKRRLGKRRLLAIGFALM-----ALGFLLLALASGLWVVLLGA--ILAGLGFGLLLP 305
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 15218057 139 LSATIMSEFANKRTRGAFIAAVFSMQGLGILVSSAVTMAV 178
Cdd:cd17473 306 TLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPL 345
|
|
| MFS_SLCO_OATP |
cd17336 |
Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; ... |
36-170 |
2.39e-03 |
|
Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; Solute carrier organic anion transporters (SLCOs) are also called organic anion transporting polypeptides (OATPs) or SLC21 (Solute carrier family 21) proteins. They are sodium-independent transporters that mediate the transport of a broad range of endo- as well as xenobiotics. Their substrates are mainly amphipathic organic anions with a molecular weight of more than 300Da, although there are a few known neutral or positively charged substrates. These include drugs including statins, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, antibiotics, antihistaminics, antihypertensives, and anticancer drugs. SLCOs/OATPs can be classified into 6 families (SLCO1-6 or OATP1-6) and each family may have subfamilies (e.g. OATP1A, OATP1B, OATP1C). Within the subfamilies, individual members are numbered according to the chronology of their identification and if there is already an ortholog known, they are given the same number. For example, the first SLCO identified, is rat OATP1A1 (encoded by the Slco1a1 gene). The second SLCO identified is the first human SLCO from the same subfamily and is called OATP1A2 (encoded by the SLCO1A2 gene). There are 11 human SLCOs/OATPs. SLCOs belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340894 [Multi-domain] Cd Length: 411 Bit Score: 40.30 E-value: 2.39e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 36 LFCIAPVMKMISHVYYNG-----------DSINTAVLSTSYAIALLGTAtgqLVFGYLGDRVGRRRVYGLCLIIMILSsf 104
Cdd:cd17336 7 LLCLLGLLQGAVVSYFVStittiekrfglSSSQSGLILSANDIGQLLAV---LLVSYFGGRGHRPRWIGIGSILMGLG-- 81
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 105 gcgfsvcttrrsCVMVSLGFF----RFFLGLGIGGDYPLSATIMSEFANKRTRGAFIAAVFSMQGLGILV 170
Cdd:cd17336 82 ------------CFLLALPHFlfvgQFLLGIGSSPLYTLGITYIDDNVSKKNSPLYIGILYAMRVLGPAL 139
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
66-187 |
2.93e-03 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 40.24 E-value: 2.93e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 66 AIALLGTATGQLVFGYLGDRVGRRRVYGLCLIIMILSSFgCGFSVCTTrrscvmVSLGFFRFFLGLGIGGDYPLSATIMS 145
Cdd:COG2807 257 SLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGLAGL-LGLLLAPG------SLPWLWAVLLGLGQGGLFPLALTLIG 329
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 15218057 146 EfankRTRGAFIAAVFS--MQGLGILVSSAVTMAVCVAFKRSGG 187
Cdd:COG2807 330 L----RARTPAEAAALSgmAQSVGYLLAALGPLLVGALHDATGS 369
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
61-449 |
3.32e-03 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 40.05 E-value: 3.32e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 61 LSTSYAIALlgtATGQLVFGYLGDRVGRRRVYGLCLIIMILSSFGCGFSvcttrrSCVMVSLGfFRFFLGLGIGGDYPLS 140
Cdd:TIGR00881 35 LLSSFSIAY---GISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFS------TSLWVMAA-LWALNGIFQGMGWPPC 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 141 ATIMSEFANKRTRGAFIAAVFSMQGLGilvssavtmavcvafkrsGGGLEVDAAAPTEADLAWRLILMIGALPAAL-TFY 219
Cdd:TIGR00881 105 GRTVTKWFSRSERGTWVSFWNCSHNVG------------------GGLLPPLVLFGIAELYSWHWVFIVPGIIAIIvSLI 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 220 WRMLMPETARYTALVE------NNIVQAAKDMQRVMSRSHISDEattdppppppppsYKLFSRCFFRLHGRDLFAASFNW 293
Cdd:TIGR00881 167 CFLLLRDSPQSCGLPPaeempnEEPDGDAEKKEEELTKKQIFLQ-------------YVLLNKVLWYISLGYVFVYVVRT 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 294 FLVDivfyTSNLLLSHIFSHYSKKPSTAENVYdaafevaELGAiiaacstIPGYWFTVYFIDKIGRVKIQIMGFFFMAVI 373
Cdd:TIGR00881 234 GILD----WSPLYLTQEKGFSKEKASWAFTLY-------ELGG-------LVGTLLAGWLSDKLFNGRRGPLAVFFMALI 295
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15218057 374 YLVAGIpyswYWSKHEhNNKGFMVLYGLVFFFCNFGPNTTTFIIPAEHFPARFRSTCHGISGAAGKLGAIVGTVGF 449
Cdd:TIGR00881 296 IVSLLV----YWLNPA-ANPLMDLICLFALGFLVYGPQMLIGVIASELAPKKAAGTAAGFVGFFAYLGGILAGLPL 366
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
56-175 |
3.53e-03 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 39.84 E-value: 3.53e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 56 INTAVLSTSYAIALLGTATGQLVFGYLGDRVGRRRVYGLCLIIMILSSFGCGFSvcttrrSCVMVSLGFFrFFLGLGIGG 135
Cdd:COG0738 243 LSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLA------PGPWLALIGL-ALVGLGLSL 315
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 15218057 136 DYPLSATIMSEFANKRTrGAFIAAVFSMQGLGILVSSAVT 175
Cdd:COG0738 316 MFPTIFSLALDGLGKRT-AAAVSAVLIMGIVGGAIGPPLI 354
|
|
| PRK11043 |
PRK11043 |
Bcr/CflA family multidrug efflux MFS transporter; |
62-109 |
3.67e-03 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182924 [Multi-domain] Cd Length: 401 Bit Score: 39.88 E-value: 3.67e-03
10 20 30 40
....*....|....*....|....*....|....*....|....*...
gi 15218057 62 STSYAIALLGTATGQLVFGYLGDRVGRRRVYGLCLIIMILSSFGCGFS 109
Cdd:PRK11043 44 SASLSLFLAGFALGQLLWGPLSDRYGRKPVLLAGLSLFALGSLGMLWV 91
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
53-218 |
3.85e-03 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 39.92 E-value: 3.85e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 53 GDSINTAVLSTSYaiaLLGTATGQLVFGYLGDRVGRRrvyglcLIIMILSSFGC-GFSVCTTRRSCVMVSLGFfrFFLGL 131
Cdd:cd06179 29 GPSSNSTWISTAW---SLAQAVLGPIVGRLSDLFGRR------WFFIGGNLLGVvGSIVAGTAKSVNMLIGGQ--ALIGI 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 132 GIGGDyPLSATIMSEFANKRTRGAFIAAVFSMQGLGILVSSAVTMAVCvafKRSGGGlevdaaapteadlaWRLILMIGA 211
Cdd:cd06179 98 GAGTQ-GLGAAVASELVPNKYRGLVQGVVNLVASPGSALGPLIAGALV---EANAAG--------------WRWIFYINA 159
|
....*..
gi 15218057 212 LPAALTF 218
Cdd:cd06179 160 IFNALAL 166
|
|
| MFS_OAT |
cd17374 |
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ... |
62-157 |
4.27e-03 |
|
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340932 [Multi-domain] Cd Length: 341 Bit Score: 39.58 E-value: 4.27e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 62 STSYAIALLGTATGQLVFGYLGDRVGRRRVYGLCLIIMILSSFGCGFSVcTTRRSCVmvslgfFRFFLGLGIGGDYPLSA 141
Cdd:cd17374 38 SVAQSIFMAGLLVGALIFGHLSDRFGRKFILLLSLLQLAIFGTCAAFAP-TFPVYCV------LRFLAGFAVSGISINTL 110
|
90
....*....|....*.
gi 15218057 142 TIMSEFANKRTRGAFI 157
Cdd:cd17374 111 ILGTEWTTPRHRALAI 126
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
66-174 |
5.41e-03 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 39.11 E-value: 5.41e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 66 AIALLGTATGQLVFGYLGDRVGRRRVYGLCLIIMILSSFGCGFSVcttrrscVMVSLGFFRFFLGLGIGGDYPLSATIMS 145
Cdd:cd17489 38 GLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLAT-------SVALLLVLRLIHGIGWGAFTTAAATLVA 110
|
90 100
....*....|....*....|....*....
gi 15218057 146 EFANKRTRGAFIaavfSMQGLGILVSSAV 174
Cdd:cd17489 111 DIIPPSRRGEGI----GYYGLATTLAMAL 135
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
49-174 |
7.16e-03 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 38.75 E-value: 7.16e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 49 VYYNGD-SINTAVLSTSYAIALLGTATGQLVFGYLGDRVGRRRVyglcliiMILSSFGCGFSvcttrrscvMVSLGFFR- 126
Cdd:cd17329 24 IYLHQQlGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPV-------MLAGLLLRALG---------FALLGFAHs 87
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 15218057 127 ------FFLGLGIGGD--YPLSATIMSEFANKRTRGAFIAAVFSMQGLGILVSSAV 174
Cdd:cd17329 88 pwlfaiALVLTGFGGGlfEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLL 143
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
56-156 |
7.45e-03 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 38.98 E-value: 7.45e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 56 INTAVLSTSYAIALLGTATGQLVFGYLGDRVGRRRVYGLCLIIMIlssfGCGFSVCTTRRSCVMVSLGffrFFLGLGIGG 135
Cdd:COG2270 271 FSTTELIVFGLLVQIVAALGALLFGRLDDRIGPKRVILVSLVIWI----VVCLAAYFLTTALAFWILG---LLIGLVMGG 343
|
90 100
....*....|....*....|.
gi 15218057 136 DYPLSATIMSEFANKRTRGAF 156
Cdd:COG2270 344 IQALSRSLLARLIPPGREAEF 364
|
|
| PRK10473 |
PRK10473 |
MdtL family multidrug efflux MFS transporter; |
59-163 |
7.59e-03 |
|
MdtL family multidrug efflux MFS transporter;
Pssm-ID: 182486 [Multi-domain] Cd Length: 392 Bit Score: 38.85 E-value: 7.59e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 59 AVLSTSYAIALLGTATGQLVFGYLGDRVGRRRVYGLCLIIMILSSFGCGFSVCTTRrscvmvsLGFFRFFLGLGIGGDYP 138
Cdd:PRK10473 38 AQLHIAFSVYLAGMAAAMLFAGKIADRSGRKPVAIPGAALFIIASLLCSLAETSSL-------FLAGRFLQGIGAGCCYV 110
|
90 100
....*....|....*....|....*
gi 15218057 139 LSATIMSEFANKRTRgafiAAVFSM 163
Cdd:PRK10473 111 VAFAILRDTLDDRRR----AKVLSL 131
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
65-171 |
9.81e-03 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 38.32 E-value: 9.81e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218057 65 YAIALLGTATGQLVFGY-LGDRVGRRRVYGLCLIIMILSSFGCGFSvcttrRSCVMVSLGFFrfFLGLGIGGDYPLSATI 143
Cdd:cd17474 240 FAGWSVLLALGSLFVGRlLKKRFGARRILVIGLLLYALSLLLLGFV-----PSLALLLIAIV--LFGLGLGLNLPLLTTL 312
|
90 100
....*....|....*....|....*...
gi 15218057 144 MSEFANKRTRGAFIAAVFSMQGLGILVS 171
Cdd:cd17474 313 VTELAPEEERGTASSLYNFVRFLGQAVG 340
|
|
| |
