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Conserved domains on  [gi|42562724|ref|NP_175728|]
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TAF RNA polymerase I subunit A [Arabidopsis thaliana]

Protein Classification

TAF RNA polymerase I subunit A domain-containing protein( domain architecture ID 10633067)

TAF RNA polymerase I subunit A domain-containing protein; TATA box binding protein (TBP) associated factor (TAF) RNA Polymerase I subunit A (TAFA1) is involved in pre-initiation complex (PIC) assembly during RNA polymerase I-dependent transcription

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
TAF1_subA pfam14929
TAF RNA Polymerase I subunit A; TATA box binding protein associated factor RNA Polymerase I ...
82-585 6.52e-80

TAF RNA Polymerase I subunit A; TATA box binding protein associated factor RNA Polymerase I subunit A is found in eukaryotes and is encoded by the gene TAF1A in humans. Its function is to aid transcription of DNA into RNA by binding to the promoter at the -10 TATA box site. It is a component of the transcription factor SL1/TIF-IB complex, involved in PIC assembly (pre-initiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation depends on the rate of association of this protein. This protein also stabilizes nucleolar transcription factor 1/UBTF on rDNA.


:

Pssm-ID: 434323  Cd Length: 365  Bit Score: 256.88  E-value: 6.52e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562724    82 ELLRNRHWNDASRVLSVLMKGTINDPCPKMNRLK-YEAHIQIVSHSetnknkADEIGRIYDTWIGQIGKQHKEERLLVWY 160
Cdd:pfam14929   1 EALLQHQWQEAAEVLSVLLQGLEDTDSPKRAREIiWRLGTEILHHH------PNSIVEIYNTFMERLKNLGVKNYLKISL 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562724   161 EQICHFIEHEMNNEAYST---------VISLMQNRDFAMLprANLFIGISFYKMWCNKFLKELQPEDADDNgsvsnises 231
Cdd:pfam14929  75 EHALHLLLNGMIEEAKRNlsnaeswryGETLMSQEKLIKL--INAYKGLLDYYLWYSKKPEELQLDDFEDD--------- 143
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562724   232 gsgslvecsgrdesvcslasevsarkdsetsvmknkkvshlsisdsetrmdtkvkvmstpyvtpppqlyaiseeneaslg 311
Cdd:pfam14929     --------------------------------------------------------------------------------
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562724   312 dgivefdptvinilgdmdpwllpfkppEDPDCYRKIVNDSYYKEAVKYmrQTLQSPPHVSLAALHPLVQILLIGGHVDEA 391
Cdd:pfam14929 144 ---------------------------FSQLNSNQEMHNYFRQAAVNL--LALISTPGVWDPFVLPYVQLLEFYGDVDEA 194
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562724   392 MKVVEeMCNkIHDVKPFRIKA-LMMEKFHRNS----DMLAKCyedILKI----DPC--CITTLKKLIGMCLEdEYSRESL 460
Cdd:pfam14929 195 LEVLN-NYA-YDKKFPFNPNAhVYLYQFLKRQqaprKKLISC---VLKIlhqlVPSdtLMLELHRLLKKSRK-EYHHKLL 268
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562724   461 TEMIALHVEASFPE--PEIWKELASCFsnffenldedrlsvcldgsedkrnpQTYSVRYNPTPKTFTKTSWTLRAKWWLN 538
Cdd:pfam14929 269 LEVIFLHLDFAGWKenLTAWKELAKCF-------------------------KQISVKKNKHPKVFTEEEWKLRKDWWPT 323
                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*..
gi 42562724   539 RHFSPQMLETEIKNvtltgDWEMMTYKAACASYIYGREFGYVTKVYE 585
Cdd:pfam14929 324 FHFSKFLAKSDWKE-----NLELALYKAAVAGILLGKEFKYVKAVSS 365
 
Name Accession Description Interval E-value
TAF1_subA pfam14929
TAF RNA Polymerase I subunit A; TATA box binding protein associated factor RNA Polymerase I ...
82-585 6.52e-80

TAF RNA Polymerase I subunit A; TATA box binding protein associated factor RNA Polymerase I subunit A is found in eukaryotes and is encoded by the gene TAF1A in humans. Its function is to aid transcription of DNA into RNA by binding to the promoter at the -10 TATA box site. It is a component of the transcription factor SL1/TIF-IB complex, involved in PIC assembly (pre-initiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation depends on the rate of association of this protein. This protein also stabilizes nucleolar transcription factor 1/UBTF on rDNA.


Pssm-ID: 434323  Cd Length: 365  Bit Score: 256.88  E-value: 6.52e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562724    82 ELLRNRHWNDASRVLSVLMKGTINDPCPKMNRLK-YEAHIQIVSHSetnknkADEIGRIYDTWIGQIGKQHKEERLLVWY 160
Cdd:pfam14929   1 EALLQHQWQEAAEVLSVLLQGLEDTDSPKRAREIiWRLGTEILHHH------PNSIVEIYNTFMERLKNLGVKNYLKISL 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562724   161 EQICHFIEHEMNNEAYST---------VISLMQNRDFAMLprANLFIGISFYKMWCNKFLKELQPEDADDNgsvsnises 231
Cdd:pfam14929  75 EHALHLLLNGMIEEAKRNlsnaeswryGETLMSQEKLIKL--INAYKGLLDYYLWYSKKPEELQLDDFEDD--------- 143
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562724   232 gsgslvecsgrdesvcslasevsarkdsetsvmknkkvshlsisdsetrmdtkvkvmstpyvtpppqlyaiseeneaslg 311
Cdd:pfam14929     --------------------------------------------------------------------------------
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562724   312 dgivefdptvinilgdmdpwllpfkppEDPDCYRKIVNDSYYKEAVKYmrQTLQSPPHVSLAALHPLVQILLIGGHVDEA 391
Cdd:pfam14929 144 ---------------------------FSQLNSNQEMHNYFRQAAVNL--LALISTPGVWDPFVLPYVQLLEFYGDVDEA 194
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562724   392 MKVVEeMCNkIHDVKPFRIKA-LMMEKFHRNS----DMLAKCyedILKI----DPC--CITTLKKLIGMCLEdEYSRESL 460
Cdd:pfam14929 195 LEVLN-NYA-YDKKFPFNPNAhVYLYQFLKRQqaprKKLISC---VLKIlhqlVPSdtLMLELHRLLKKSRK-EYHHKLL 268
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562724   461 TEMIALHVEASFPE--PEIWKELASCFsnffenldedrlsvcldgsedkrnpQTYSVRYNPTPKTFTKTSWTLRAKWWLN 538
Cdd:pfam14929 269 LEVIFLHLDFAGWKenLTAWKELAKCF-------------------------KQISVKKNKHPKVFTEEEWKLRKDWWPT 323
                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*..
gi 42562724   539 RHFSPQMLETEIKNvtltgDWEMMTYKAACASYIYGREFGYVTKVYE 585
Cdd:pfam14929 324 FHFSKFLAKSDWKE-----NLELALYKAAVAGILLGKEFKYVKAVSS 365
 
Name Accession Description Interval E-value
TAF1_subA pfam14929
TAF RNA Polymerase I subunit A; TATA box binding protein associated factor RNA Polymerase I ...
82-585 6.52e-80

TAF RNA Polymerase I subunit A; TATA box binding protein associated factor RNA Polymerase I subunit A is found in eukaryotes and is encoded by the gene TAF1A in humans. Its function is to aid transcription of DNA into RNA by binding to the promoter at the -10 TATA box site. It is a component of the transcription factor SL1/TIF-IB complex, involved in PIC assembly (pre-initiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation depends on the rate of association of this protein. This protein also stabilizes nucleolar transcription factor 1/UBTF on rDNA.


Pssm-ID: 434323  Cd Length: 365  Bit Score: 256.88  E-value: 6.52e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562724    82 ELLRNRHWNDASRVLSVLMKGTINDPCPKMNRLK-YEAHIQIVSHSetnknkADEIGRIYDTWIGQIGKQHKEERLLVWY 160
Cdd:pfam14929   1 EALLQHQWQEAAEVLSVLLQGLEDTDSPKRAREIiWRLGTEILHHH------PNSIVEIYNTFMERLKNLGVKNYLKISL 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562724   161 EQICHFIEHEMNNEAYST---------VISLMQNRDFAMLprANLFIGISFYKMWCNKFLKELQPEDADDNgsvsnises 231
Cdd:pfam14929  75 EHALHLLLNGMIEEAKRNlsnaeswryGETLMSQEKLIKL--INAYKGLLDYYLWYSKKPEELQLDDFEDD--------- 143
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562724   232 gsgslvecsgrdesvcslasevsarkdsetsvmknkkvshlsisdsetrmdtkvkvmstpyvtpppqlyaiseeneaslg 311
Cdd:pfam14929     --------------------------------------------------------------------------------
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562724   312 dgivefdptvinilgdmdpwllpfkppEDPDCYRKIVNDSYYKEAVKYmrQTLQSPPHVSLAALHPLVQILLIGGHVDEA 391
Cdd:pfam14929 144 ---------------------------FSQLNSNQEMHNYFRQAAVNL--LALISTPGVWDPFVLPYVQLLEFYGDVDEA 194
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562724   392 MKVVEeMCNkIHDVKPFRIKA-LMMEKFHRNS----DMLAKCyedILKI----DPC--CITTLKKLIGMCLEdEYSRESL 460
Cdd:pfam14929 195 LEVLN-NYA-YDKKFPFNPNAhVYLYQFLKRQqaprKKLISC---VLKIlhqlVPSdtLMLELHRLLKKSRK-EYHHKLL 268
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562724   461 TEMIALHVEASFPE--PEIWKELASCFsnffenldedrlsvcldgsedkrnpQTYSVRYNPTPKTFTKTSWTLRAKWWLN 538
Cdd:pfam14929 269 LEVIFLHLDFAGWKenLTAWKELAKCF-------------------------KQISVKKNKHPKVFTEEEWKLRKDWWPT 323
                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*..
gi 42562724   539 RHFSPQMLETEIKNvtltgDWEMMTYKAACASYIYGREFGYVTKVYE 585
Cdd:pfam14929 324 FHFSKFLAKSDWKE-----NLELALYKAAVAGILLGKEFKYVKAVSS 365
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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