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Conserved domains on  [gi|30696438|ref|NP_176259|]
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UbiA prenyltransferase family protein [Arabidopsis thaliana]

Protein Classification

prenyltransferase( domain architecture ID 10791491)

prenyltransferase transfers an isoprenyl group to an aromatic substrate acceptor; may be involved in the biosynthesis of menaquinone or phylloquinone

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PLN02922 PLN02922
prenyltransferase
1-287 5.98e-173

prenyltransferase


:

Pssm-ID: 215499  Cd Length: 315  Bit Score: 480.39  E-value: 5.98e-173
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30696438    1 MYSVALVPLTVGASAAYLETGLFLARRYVTLLLSSILIITWLNLSNDVYDFDTGADKNKMESVVNLVGSRTGTLAAAITS 80
Cdd:PLN02922  26 MYSVALVPLTVGAAAAYLQTGLFDARRYGTLLLSSVLVITWLNLSNDAYDADTGVDKNKKESVVNLVGSRRGVLAAAIGC 105
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30696438   81 LALGVSGLVWTSLNASNIRAILLLASAILCGYVYQCPPFRLSYQGLGEPLCFAAFGPFATTAFYLLLGS---SSEMRHLP 157
Cdd:PLN02922 106 LALGAAGLVWASLVAGNIRVILLLAAAILCGYVYQCPPFRLSYKGLGEPLCFAAFGPLATTAFYLALASgagGSEMAILP 185
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30696438  158 LSGRVLSSSVLVGFTTSLILFCSHFHQVDGDLAVGKYSPLVRLGTEKGAFVVRWTIRLLYSMLLVLGLTRILPLPCTLMC 237
Cdd:PLN02922 186 LTPTVLSASVLVGLTTTLILFCSHFHQIDGDRAVGKMSPLVRLGTEKGSRVVRWAVLLLYSLLAALGLLKALPLPCALLC 265
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 30696438  238 FLTLPVGNLVSSYVEKHHKDNGKIFMAKYYCVRLHALLGAALSLGLVIAR 287
Cdd:PLN02922 266 FLTLPLGKLVVDFVEKNHKDNAKIFMAKYYCVRLHALFGAALALGLVLAR 315
 
Name Accession Description Interval E-value
PLN02922 PLN02922
prenyltransferase
1-287 5.98e-173

prenyltransferase


Pssm-ID: 215499  Cd Length: 315  Bit Score: 480.39  E-value: 5.98e-173
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30696438    1 MYSVALVPLTVGASAAYLETGLFLARRYVTLLLSSILIITWLNLSNDVYDFDTGADKNKMESVVNLVGSRTGTLAAAITS 80
Cdd:PLN02922  26 MYSVALVPLTVGAAAAYLQTGLFDARRYGTLLLSSVLVITWLNLSNDAYDADTGVDKNKKESVVNLVGSRRGVLAAAIGC 105
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30696438   81 LALGVSGLVWTSLNASNIRAILLLASAILCGYVYQCPPFRLSYQGLGEPLCFAAFGPFATTAFYLLLGS---SSEMRHLP 157
Cdd:PLN02922 106 LALGAAGLVWASLVAGNIRVILLLAAAILCGYVYQCPPFRLSYKGLGEPLCFAAFGPLATTAFYLALASgagGSEMAILP 185
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30696438  158 LSGRVLSSSVLVGFTTSLILFCSHFHQVDGDLAVGKYSPLVRLGTEKGAFVVRWTIRLLYSMLLVLGLTRILPLPCTLMC 237
Cdd:PLN02922 186 LTPTVLSASVLVGLTTTLILFCSHFHQIDGDRAVGKMSPLVRLGTEKGSRVVRWAVLLLYSLLAALGLLKALPLPCALLC 265
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 30696438  238 FLTLPVGNLVSSYVEKHHKDNGKIFMAKYYCVRLHALLGAALSLGLVIAR 287
Cdd:PLN02922 266 FLTLPLGKLVVDFVEKNHKDNAKIFMAKYYCVRLHALFGAALALGLVLAR 315
menA_cyano-plnt TIGR02235
1,4-dihydroxy-2-naphthoate phytyltransferase; This family of phytyltransferases, found in ...
1-270 2.72e-65

1,4-dihydroxy-2-naphthoate phytyltransferase; This family of phytyltransferases, found in plants and cyanobacteria, are involved in the biosythesis of phylloquinone (Vitamin K1). Phylloquinone is a critical component of photosystem I. The closely related MenA enzyme from bacteria transfers a prenyl group (which only differs in the saturation of the isoprenyl groups) in the biosynthesis of menaquinone. Activity towards both substrates in certain organisms should be considered a possibility. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 131289  Cd Length: 285  Bit Score: 205.75  E-value: 2.72e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30696438     1 MYSVALVPLTVGASAAYLETGLFLARRYVTLLLSSILIITWLNLSNDVYDFDTGADKNKMESVVNLVGSRTGTLAAAITS 80
Cdd:TIGR02235  10 LYSVAVMPILVGTAVAWGQGGVFHLDRFALFLIAAILILAWINLTNDVFDSDTGIDRFKLHSIVNLTGSRSLVFWLANFF 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30696438    81 LALGVSGLvWTSLNASNIRAILLLASAILCGYVYQCPPFRLSYQGLGEPLCFAAFGPFATTAFYLLLGSSSEMRHLPlsg 160
Cdd:TIGR02235  90 LLIGLVGI-AALSWRWQITVLALVGLCCFLGYLYQGPPFRLGYQGLGEPICWLCFGPLAIAAALYAQSQSFSLIPWK--- 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30696438   161 rvlsSSVLVGFTTSLILFCSHFHQVDGDLAVGKYSPLVRLGTEKGAFVVRWTIRLLYSMLLVLGLTRILPLPCtLMCFLT 240
Cdd:TIGR02235 166 ----ASILVGLATTLILFCSHFHQVEDDLAHGKRSPVVRLGTKLAAKIVPWVISLSYVVLLIAVIGGFLPWTT-LLALAS 240
                         250       260       270
                  ....*....|....*....|....*....|
gi 30696438   241 LPVGNLVSSYVEKHHKDNGKIFMAKYYCVR 270
Cdd:TIGR02235 241 IPWAVKLIRLVRQNHNNPEQISNCKFIAVR 270
PT_UbiA_UBIAD1 cd13962
1,4-Dihydroxy-2-naphthoate octaprenyltransferase; Human UBIAD1 is an enzyme involved in the ...
1-265 3.91e-43

1,4-Dihydroxy-2-naphthoate octaprenyltransferase; Human UBIAD1 is an enzyme involved in the synthesis of MK-4. Menaquinones (MKs, also called bacterial forms) are one of the two forms of natural vitamin K, the other being the plant form, phylloquinone (PK). All forms of vitamin K have a 2-methyl-1,4-naphthoquinone (menadione; K3) ring structure in common. At the 3-position of the ring, PK has a phytyl side chain while MKs have several repeating prenyl units. Prenyltransferases (PTs) catalyze the regioselective transfer of prenyl moieties onto a wide variety of substrates and play an important role in many biosynthetic pathways.


Pssm-ID: 260125  Cd Length: 283  Bit Score: 148.82  E-value: 3.91e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30696438   1 MYSVALVPLTVGASAAYLETGLFLARRYVTLLLSSILIITWLNLSNDVYDFDTGADKNKMESVVNLVG----SRTGTLAA 76
Cdd:cd13962   8 TLPASLAPVLLGTALAYYLGGFFNWLLFLLALLAALLLQIGVNLANDYFDYKKGTDTEPRSGPSRVLVsgllSPRQVLRA 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30696438  77 AITSLALG-VSGLVWTSLnaSNIRAILLLASAILCGYVYQCPPFRLSYQGLGEPLCFAAFGPFATTAFYLLLGSSsemrh 155
Cdd:cd13962  88 ALVLLLLAaLLGLYLVAL--GGWLLLLLGLLGILAGYFYTGGPFPLSYRGLGELFVFLFFGLLAVLGTYYVQTGS----- 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30696438 156 lpLSGRVLSSSVLVGFTTSLILFCSHFHQVDGDLAVGKYSPLVRLGTEKGAFVVRWTIRLLYSMLLVLGLTRILPLPCTL 235
Cdd:cd13962 161 --LSWEVLLAALPLGLLIAAILLANNIRDIEADRAAGKRTLAVRLGRKRARRLYAALLLLAYLLLLLLVLLGLLPLWSLL 238
                       250       260       270
                ....*....|....*....|....*....|
gi 30696438 236 MCFLTLPVGNLVSSYVEKHHKDNGKIFMAK 265
Cdd:cd13962 239 ALLSLPLAIKLLRRLLRKADKPLLLIALKL 268
MenA COG1575
1,4-dihydroxy-2-naphthoate polyprenyltransferase [Coenzyme transport and metabolism]; 1, ...
1-242 2.95e-38

1,4-dihydroxy-2-naphthoate polyprenyltransferase [Coenzyme transport and metabolism]; 1,4-dihydroxy-2-naphthoate polyprenyltransferase is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 441183  Cd Length: 290  Bit Score: 136.04  E-value: 2.95e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30696438   1 MYSVALVPLTVGASAAYLETGLFLARRYVTLLLSSILIITWLNLSNDVYDFDTGADKNKMESVVNLVGSRTGT----LAA 76
Cdd:COG1575  10 TLPAAVAPVLLGTALAYYETGSFNWLLFLLALLAALLLQIGVNLANDYFDYKKGTDTEERVGPSRVIVSGLLSpkqvLRA 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30696438  77 AITSLALGVSG---LVWTslnaSNIRAILLLASAILCGYVYQCPPFRLSYQGLGEPLCFAAFGPFATT-AFYLLLGSsse 152
Cdd:COG1575  90 ALLLLALALLLglyLVLL----SGWPLLLLGLLGILAAIFYTGGPFPLGYRGLGELFVFLFFGLVAVLgTYYVQTGT--- 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30696438 153 mrhlpLSGRVLSSSVLVGFTTSLILFCSHFHQVDGDLAVGKYSPLVRLGTEKGAFVVRWTIRLLYSMLLVLGLTRILPLP 232
Cdd:COG1575 163 -----LSWAALLASLPVGLLSAAVLLANNLRDIETDRAAGKRTLAVRLGRKRARRLYAALLLLAYLLILLLVLLGLLPPW 237
                       250
                ....*....|
gi 30696438 233 cTLMCFLTLP 242
Cdd:COG1575 238 -ALLALLSLP 246
UbiA pfam01040
UbiA prenyltransferase family;
5-263 4.55e-12

UbiA prenyltransferase family;


Pssm-ID: 460038 [Multi-domain]  Cd Length: 250  Bit Score: 64.56  E-value: 4.55e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30696438     5 ALVPLTVGASAAYleTGLFLARRYVTLLLSSILIITWLNLSNDVYDFDTGAD-KNKMESVV--NLVgSRTGTLAAAITSL 81
Cdd:pfam01040   1 LLIPALAGLALAA--GGVPDLLLLLLALLGTVLARAAANALNDYYDRDIDAImPRTPNRPLpsGRI-SPREALIFALVLL 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30696438    82 ALGVSGLVWTslnasNIRAILLLASAILCGYVYqcpPFRLSYQGL-GEPLCFAAFGPFATTAFYLLLGSssemrhlpLSG 160
Cdd:pfam01040  78 ALGLLLLLLL-----NPLTALLGLAALLLYVLY---TLRLKRRTLlGQLVGGLAFGLPPLLGWAAVTGS--------LSP 141
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30696438   161 RVLSSSVLVGFTTSLILFCSHFHQVDGDLAVGKYSPLVRLGTEKGAFVVRWTIRLLYSMLLVLGLTRILPLP-CTLMCFL 239
Cdd:pfam01040 142 LALLLALALFLWTWAIALANDLRDREDDRKAGIKTLPVVLGRKAARILLALLLAVALLLLLLLLLLLLGGLYlLLALLLA 221
                         250       260
                  ....*....|....*....|....
gi 30696438   240 TLPVGNLVSSYVEKHHKDNGKIFM 263
Cdd:pfam01040 222 ALALLYAARLLRLRDPKKDAKAFF 245
 
Name Accession Description Interval E-value
PLN02922 PLN02922
prenyltransferase
1-287 5.98e-173

prenyltransferase


Pssm-ID: 215499  Cd Length: 315  Bit Score: 480.39  E-value: 5.98e-173
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30696438    1 MYSVALVPLTVGASAAYLETGLFLARRYVTLLLSSILIITWLNLSNDVYDFDTGADKNKMESVVNLVGSRTGTLAAAITS 80
Cdd:PLN02922  26 MYSVALVPLTVGAAAAYLQTGLFDARRYGTLLLSSVLVITWLNLSNDAYDADTGVDKNKKESVVNLVGSRRGVLAAAIGC 105
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30696438   81 LALGVSGLVWTSLNASNIRAILLLASAILCGYVYQCPPFRLSYQGLGEPLCFAAFGPFATTAFYLLLGS---SSEMRHLP 157
Cdd:PLN02922 106 LALGAAGLVWASLVAGNIRVILLLAAAILCGYVYQCPPFRLSYKGLGEPLCFAAFGPLATTAFYLALASgagGSEMAILP 185
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30696438  158 LSGRVLSSSVLVGFTTSLILFCSHFHQVDGDLAVGKYSPLVRLGTEKGAFVVRWTIRLLYSMLLVLGLTRILPLPCTLMC 237
Cdd:PLN02922 186 LTPTVLSASVLVGLTTTLILFCSHFHQIDGDRAVGKMSPLVRLGTEKGSRVVRWAVLLLYSLLAALGLLKALPLPCALLC 265
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 30696438  238 FLTLPVGNLVSSYVEKHHKDNGKIFMAKYYCVRLHALLGAALSLGLVIAR 287
Cdd:PLN02922 266 FLTLPLGKLVVDFVEKNHKDNAKIFMAKYYCVRLHALFGAALALGLVLAR 315
PRK07419 PRK07419
2-carboxy-1,4-naphthoquinone phytyltransferase;
1-270 3.60e-85

2-carboxy-1,4-naphthoquinone phytyltransferase;


Pssm-ID: 236015  Cd Length: 304  Bit Score: 257.14  E-value: 3.60e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30696438    1 MYSVALVPLTVGASAAYLETGLFLARRYVTLLLSSILIITWLNLSNDVYDFDTGADKNKMESVVNLVGSRTGTLAAAITS 80
Cdd:PRK07419  23 MYSVAIMPILVGTAWALGETGVFRLDQFITFLLAAILILAWENLSNDVFDADTGIDKNKFHSVVNLTGNKSLVFWLANLF 102
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30696438   81 LALGVSGLVWTSLNaSNIRAILLLASAILCGYVYQCPPFRLSYQGLGEPLCFAAFGPFATTAFYLLLGSSSemrhlplSG 160
Cdd:PRK07419 103 LLLGLLGILAIALQ-SDWTVLGLVLLCCFLGYLYQGPPFRLGYQGLGEPLCFLAFGPLAVAAALYSQTPSW-------SL 174
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30696438  161 RVLSSSVLVGFTTSLILFCSHFHQVDGDLAVGKYSPLVRLGTEKGAFVVRWTIRLLYSMLLVLGLTRILPLPCtLMCFLT 240
Cdd:PRK07419 175 IPLAASIILGLATSLILFCSHFHQVEDDLAAGKRSPIVRLGTKRGAQLLPWIVGLIYALELLPVLLGFWPWTT-LLSLLS 253
                        250       260       270
                 ....*....|....*....|....*....|
gi 30696438  241 LPVGNLVSSYVEKHHKDNGKIFMAKYYCVR 270
Cdd:PRK07419 254 LPFAIKLIRLVRENHDQPEKVSNSKFIAVR 283
menA_cyano-plnt TIGR02235
1,4-dihydroxy-2-naphthoate phytyltransferase; This family of phytyltransferases, found in ...
1-270 2.72e-65

1,4-dihydroxy-2-naphthoate phytyltransferase; This family of phytyltransferases, found in plants and cyanobacteria, are involved in the biosythesis of phylloquinone (Vitamin K1). Phylloquinone is a critical component of photosystem I. The closely related MenA enzyme from bacteria transfers a prenyl group (which only differs in the saturation of the isoprenyl groups) in the biosynthesis of menaquinone. Activity towards both substrates in certain organisms should be considered a possibility. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 131289  Cd Length: 285  Bit Score: 205.75  E-value: 2.72e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30696438     1 MYSVALVPLTVGASAAYLETGLFLARRYVTLLLSSILIITWLNLSNDVYDFDTGADKNKMESVVNLVGSRTGTLAAAITS 80
Cdd:TIGR02235  10 LYSVAVMPILVGTAVAWGQGGVFHLDRFALFLIAAILILAWINLTNDVFDSDTGIDRFKLHSIVNLTGSRSLVFWLANFF 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30696438    81 LALGVSGLvWTSLNASNIRAILLLASAILCGYVYQCPPFRLSYQGLGEPLCFAAFGPFATTAFYLLLGSSSEMRHLPlsg 160
Cdd:TIGR02235  90 LLIGLVGI-AALSWRWQITVLALVGLCCFLGYLYQGPPFRLGYQGLGEPICWLCFGPLAIAAALYAQSQSFSLIPWK--- 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30696438   161 rvlsSSVLVGFTTSLILFCSHFHQVDGDLAVGKYSPLVRLGTEKGAFVVRWTIRLLYSMLLVLGLTRILPLPCtLMCFLT 240
Cdd:TIGR02235 166 ----ASILVGLATTLILFCSHFHQVEDDLAHGKRSPVVRLGTKLAAKIVPWVISLSYVVLLIAVIGGFLPWTT-LLALAS 240
                         250       260       270
                  ....*....|....*....|....*....|
gi 30696438   241 LPVGNLVSSYVEKHHKDNGKIFMAKYYCVR 270
Cdd:TIGR02235 241 IPWAVKLIRLVRQNHNNPEQISNCKFIAVR 270
PT_UbiA_UBIAD1 cd13962
1,4-Dihydroxy-2-naphthoate octaprenyltransferase; Human UBIAD1 is an enzyme involved in the ...
1-265 3.91e-43

1,4-Dihydroxy-2-naphthoate octaprenyltransferase; Human UBIAD1 is an enzyme involved in the synthesis of MK-4. Menaquinones (MKs, also called bacterial forms) are one of the two forms of natural vitamin K, the other being the plant form, phylloquinone (PK). All forms of vitamin K have a 2-methyl-1,4-naphthoquinone (menadione; K3) ring structure in common. At the 3-position of the ring, PK has a phytyl side chain while MKs have several repeating prenyl units. Prenyltransferases (PTs) catalyze the regioselective transfer of prenyl moieties onto a wide variety of substrates and play an important role in many biosynthetic pathways.


Pssm-ID: 260125  Cd Length: 283  Bit Score: 148.82  E-value: 3.91e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30696438   1 MYSVALVPLTVGASAAYLETGLFLARRYVTLLLSSILIITWLNLSNDVYDFDTGADKNKMESVVNLVG----SRTGTLAA 76
Cdd:cd13962   8 TLPASLAPVLLGTALAYYLGGFFNWLLFLLALLAALLLQIGVNLANDYFDYKKGTDTEPRSGPSRVLVsgllSPRQVLRA 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30696438  77 AITSLALG-VSGLVWTSLnaSNIRAILLLASAILCGYVYQCPPFRLSYQGLGEPLCFAAFGPFATTAFYLLLGSSsemrh 155
Cdd:cd13962  88 ALVLLLLAaLLGLYLVAL--GGWLLLLLGLLGILAGYFYTGGPFPLSYRGLGELFVFLFFGLLAVLGTYYVQTGS----- 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30696438 156 lpLSGRVLSSSVLVGFTTSLILFCSHFHQVDGDLAVGKYSPLVRLGTEKGAFVVRWTIRLLYSMLLVLGLTRILPLPCTL 235
Cdd:cd13962 161 --LSWEVLLAALPLGLLIAAILLANNIRDIEADRAAGKRTLAVRLGRKRARRLYAALLLLAYLLLLLLVLLGLLPLWSLL 238
                       250       260       270
                ....*....|....*....|....*....|
gi 30696438 236 MCFLTLPVGNLVSSYVEKHHKDNGKIFMAK 265
Cdd:cd13962 239 ALLSLPLAIKLLRRLLRKADKPLLLIALKL 268
MenA COG1575
1,4-dihydroxy-2-naphthoate polyprenyltransferase [Coenzyme transport and metabolism]; 1, ...
1-242 2.95e-38

1,4-dihydroxy-2-naphthoate polyprenyltransferase [Coenzyme transport and metabolism]; 1,4-dihydroxy-2-naphthoate polyprenyltransferase is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 441183  Cd Length: 290  Bit Score: 136.04  E-value: 2.95e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30696438   1 MYSVALVPLTVGASAAYLETGLFLARRYVTLLLSSILIITWLNLSNDVYDFDTGADKNKMESVVNLVGSRTGT----LAA 76
Cdd:COG1575  10 TLPAAVAPVLLGTALAYYETGSFNWLLFLLALLAALLLQIGVNLANDYFDYKKGTDTEERVGPSRVIVSGLLSpkqvLRA 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30696438  77 AITSLALGVSG---LVWTslnaSNIRAILLLASAILCGYVYQCPPFRLSYQGLGEPLCFAAFGPFATT-AFYLLLGSsse 152
Cdd:COG1575  90 ALLLLALALLLglyLVLL----SGWPLLLLGLLGILAAIFYTGGPFPLGYRGLGELFVFLFFGLVAVLgTYYVQTGT--- 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30696438 153 mrhlpLSGRVLSSSVLVGFTTSLILFCSHFHQVDGDLAVGKYSPLVRLGTEKGAFVVRWTIRLLYSMLLVLGLTRILPLP 232
Cdd:COG1575 163 -----LSWAALLASLPVGLLSAAVLLANNLRDIETDRAAGKRTLAVRLGRKRARRLYAALLLLAYLLILLLVLLGLLPPW 237
                       250
                ....*....|
gi 30696438 233 cTLMCFLTLP 242
Cdd:COG1575 238 -ALLALLSLP 246
UbiA pfam01040
UbiA prenyltransferase family;
5-263 4.55e-12

UbiA prenyltransferase family;


Pssm-ID: 460038 [Multi-domain]  Cd Length: 250  Bit Score: 64.56  E-value: 4.55e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30696438     5 ALVPLTVGASAAYleTGLFLARRYVTLLLSSILIITWLNLSNDVYDFDTGAD-KNKMESVV--NLVgSRTGTLAAAITSL 81
Cdd:pfam01040   1 LLIPALAGLALAA--GGVPDLLLLLLALLGTVLARAAANALNDYYDRDIDAImPRTPNRPLpsGRI-SPREALIFALVLL 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30696438    82 ALGVSGLVWTslnasNIRAILLLASAILCGYVYqcpPFRLSYQGL-GEPLCFAAFGPFATTAFYLLLGSssemrhlpLSG 160
Cdd:pfam01040  78 ALGLLLLLLL-----NPLTALLGLAALLLYVLY---TLRLKRRTLlGQLVGGLAFGLPPLLGWAAVTGS--------LSP 141
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30696438   161 RVLSSSVLVGFTTSLILFCSHFHQVDGDLAVGKYSPLVRLGTEKGAFVVRWTIRLLYSMLLVLGLTRILPLP-CTLMCFL 239
Cdd:pfam01040 142 LALLLALALFLWTWAIALANDLRDREDDRKAGIKTLPVVLGRKAARILLALLLAVALLLLLLLLLLLLGGLYlLLALLLA 221
                         250       260
                  ....*....|....*....|....
gi 30696438   240 TLPVGNLVSSYVEKHHKDNGKIFM 263
Cdd:pfam01040 222 ALALLYAARLLRLRDPKKDAKAFF 245
PRK06080 PRK06080
1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated
5-242 4.24e-11

1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated


Pssm-ID: 235695  Cd Length: 293  Bit Score: 62.08  E-value: 4.24e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30696438    5 ALVPLTVGASAAYLET----GLFLArryvtLLLSSILIITWLNLSNDVYDFDTGADKNKMESVVNLVGSRTGT----LAA 76
Cdd:PRK06080  18 AFAPVLVGTALAYWLGsfhpLLALL-----ALLAALLLQIATNLANDYGDYVKGTDTEDRVGPLRAIGRGGISpkqvKRA 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30696438   77 AITSLALG-VSGLVwtsLNASNIRAILLL-ASAILCGYVYQCPPFRLSYQGLGEPLCFAAFGPFATT-AFYLLLGSssem 153
Cdd:PRK06080  93 AIAFFGLAaLLGLY---LVAVSGWWLLLLgLLCIAAAILYTGGPKPYGYTGLGELFVGVFFGLVIVLgTYYLQAGT---- 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30696438  154 rhlpLSGRVLSSSVLVGFTTSLILFCSHFHQVDGDLAVGKYSPLVRLGTEKGAFVVRWTIRLLYSMLLVLGLTRILPLPC 233
Cdd:PRK06080 166 ----VDSAVFLPALPCGLLIGAVLLANNIRDIETDRENGKNTLAVRLGDKNARRLHAALLALAYLCIVLLALLGLASPWG 241

                 ....*....
gi 30696438  234 tLMCFLTLP 242
Cdd:PRK06080 242 -LLFLLSLP 249
menA TIGR00751
1,4-dihydroxy-2-naphthoate octaprenyltransferase; This membrane-associated enzyme converts 1, ...
5-241 9.77e-08

1,4-dihydroxy-2-naphthoate octaprenyltransferase; This membrane-associated enzyme converts 1,4-dihydroxy-2-naphthoic acid (DHNA) to demethylmenaquinone, a step in menaquinone biosynthesis. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 129834  Cd Length: 284  Bit Score: 52.19  E-value: 9.77e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30696438     5 ALVPLTVGASAAYLETGlFLARRYVTLLLSSILIITWLNLSNDVYDFDTGADKNKMESVVNLVGSRTGT----LAAAITS 80
Cdd:TIGR00751   8 AIAPIVAGTALAAWLHA-FVWLVALLALATAVLLQILSNYANDYGDGIKGSDTDDRIGPLRGVQKGLITprevKTALITS 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30696438    81 LALG-VSGLVWTSLNASNIRAILLLAS----AILCGYVYQCPPFRLSYQGLGEPLCFAAFGPFAttafyllLGSSSEMRH 155
Cdd:TIGR00751  87 VALGaLSGLVLALLAAPNLSDLFWFIAlgalCIAAAITYTVGSKPYGYAGLGDISVLVFFGPLA-------VLGTQYLQA 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30696438   156 LPLSGRVLSSSVLVGFTTSLILFCSHFHQVDGDLAVGKYSPLVRLGTEKGafvvrwtiRLLYSMLL----VLGLTRILPL 231
Cdd:TIGR00751 160 HRVDWVGILPAVATGLLACAVLNINNLRDIPTDARAGKNTLAVRLGDART--------RMYHQGLLavagVCTFVFMLAT 231
                         250
                  ....*....|
gi 30696438   232 PCTLMCFLTL 241
Cdd:TIGR00751 232 PISWWCVLFL 241
ubiA PRK05951
prenyltransferase; Reviewed
12-243 2.84e-06

prenyltransferase; Reviewed


Pssm-ID: 180323  Cd Length: 296  Bit Score: 47.85  E-value: 2.84e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30696438   12 GASAAYLETGLFLARRYVTLLLSSILIITWLNLSNDVYDFDTGADKNKMES-----VVNLVGSRTGTLAAAItSLALGVS 86
Cdd:PRK05951  26 SIAYGYYLFRSFDPLLGALMLLGYFLLHASLNVFNDYKDYVLDCDHHETTGyrqhpIQAGIMTLGHLRVLGI-ALGAIAL 104
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30696438   87 GLVWTSLNASNIRAILLLASAILCGYVYQCPPFRLSYQGLGEPLCFAAFGPFATT-AFYLLLGSssemrhlpLSGRVLSS 165
Cdd:PRK05951 105 QLGWSLVLDRGIGAVTLALLGVFLWTCYMGPPFFLKYRWLGEHLVFYAWSHMLVMgLIYVWLGN--------LSSPNLLA 176
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 30696438  166 SVLVGFTTSLILFCSHFHQVDGDLAVGKYSPLVRLGTEKGAFVVrwtIRLLYSML-LVLGLTRILPLPCTLMCFLTLPV 243
Cdd:PRK05951 177 GVPLGLLMALVLLSNNLRDIEDDERKGIPTLAVIFGRRGAALYI---FALLSPYViLQILLIAILTPLISLWALLSLLV 252
PT_UbiA cd13956
UbiA family of prenyltransferases (PTases); Many characterized members of the UbiA ...
4-232 1.44e-05

UbiA family of prenyltransferases (PTases); Many characterized members of the UbiA prenyltransferase family are aromatic prenyltransferases and play an important role in the biosynthesis of heme, chlorophyll, vitamin E, and vitamin K. They contain two copies of a motif similar to the active site DxxD motif of trans-prenyltransferases and are potentially related. Prenyltransferases (PTs) catalyze the regioselective transfer of prenyl moieties onto a wide variety of substrates and play an important role in many biosynthetic pathways.


Pssm-ID: 260119 [Multi-domain]  Cd Length: 271  Bit Score: 45.42  E-value: 1.44e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30696438   4 VALVPLTVGASAAYL-ETGLFLARRYVTLLLSSILIITWLNLSNDVYDFDTGADKNKMESVVnlVGSRTGTLAAAITSLA 82
Cdd:cd13956   9 LLYVLAPALAGAALAgAFAGPLPALLLLALLAVFLGAGAGYALNDYTDRELDAINKPDRPLP--SGRLSPRQALAFAAAL 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30696438  83 LGVSGLVWTSLNAsniRAILLLASAILCGYVYQCPPFRLSYQGLGeplcfaaFGPFATTAfyLLLGSSSEMRHLPLSGRV 162
Cdd:cd13956  87 LLVGLALALALGP---LALLLLLAGLLLGLAYSLGLKRLKLGGWG-------VLGYATGL--ALLPGLGAVAAGGLVPLA 154
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30696438 163 LSSSVLVGFTTSLILFCSHFHQVDGDLAVGKYSPLVRLGtEKGAFVVRWTIRLLYSMLLVLGLTRILPLP 232
Cdd:cd13956 155 LLLALVFLLLGLGINLYNDLPDVEGDRAAGIRTLPVRLG-PRRARRLAAGLLLAALILVVLLAVAGLLGP 223
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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