|
Name |
Accession |
Description |
Interval |
E-value |
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
3-440 |
7.20e-25 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 108.07 E-value: 7.20e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680505 3 RGGRSYVTSPPSFSNDAKKLLVCTGNTVSVFSAATGLQITSLEGHTAPVTTLivvpASSPAQKILcycWTASLDGTIRHW 82
Cdd:COG2319 75 LGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSV----AFSPDGKTL---ASGSADGTVRLW 147
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680505 83 DFSGPELLKTidaqlpiysmvipsllsepqqidkrrelsgklvayvsvedisvvnqgskeLRGHirrfnlaksriprgdt 162
Cdd:COG2319 148 DLATGKLLRT--------------------------------------------------LTGH---------------- 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680505 163 lkeTAEPESIVISPSGEFF---GIRHkcKIHIWDVPSGGSRHAVSrkmtlHHTKVINAFAFHPTERVIAAGDVTGRVLIW 239
Cdd:COG2319 162 ---SGAVTSVAFSPDGKLLasgSDDG--TVRLWDLATGKLLRTLT-----GHTGAVRSVAFSPDGKLLASGSADGTVRLW 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680505 240 rgfgnrklalgnqkkkvramvDLDNAGVRgeddaescTTWHWHSAEVNVLNFSSDGAYLYSGGREGVLVVWQLDTGK-KK 318
Cdd:COG2319 232 ---------------------DLATGKLL--------RTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGElLR 282
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680505 319 FLPRIGSPLLYFMWSPDPTLSSVVCADNQIHLLKMPSMEILRTISGikpppslprmYEGLASTVAFDRSSGIAALCTENY 398
Cdd:COG2319 283 TLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTG----------HTGAVRSVAFSPDGKTLASGSDDG 352
|
410 420 430 440
....*....|....*....|....*....|....*....|..
gi 30680505 399 CVQLYNLLNDRGISEIqvceRNHQPGdeitvvVTAVALSLDG 440
Cdd:COG2319 353 TVRLWDLATGELLRTL----TGHTGA------VTSVAFSPDG 384
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
3-350 |
1.57e-18 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 86.62 E-value: 1.57e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680505 3 RGGRSYVTSPpSFSNDAKKLLVCTG-NTVSVFSAATGLQITSLEGHTAPVTTLIVVPASspaQKILCycwtASLDGTIRH 81
Cdd:cd00200 6 KGHTGGVTCV-AFSPDGKLLATGSGdGTIKVWDLETGELLRTLKGHTGPVRDVAASADG---TYLAS----GSSDKTIRL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680505 82 WDFSGPELLKTI-DAQLPIYSMVIpsllsepqqIDKRRELSGklvayvSVEDISVV------NQGSKELRGHirrfnlak 154
Cdd:cd00200 78 WDLETGECVRTLtGHTSYVSSVAF---------SPDGRILSS------SSRDKTIKvwdvetGKCLTTLRGH-------- 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680505 155 sriprgdtlkeTAEPESIVISPSGEF-FGIRHKCKIHIWDVPSGGSRHavsrkmTLH-HTKVINAFAFHPTERVIAAGDV 232
Cdd:cd00200 135 -----------TDWVNSVAFSPDGTFvASSSQDGTIKLWDLRTGKCVA------TLTgHTGEVNSVAFSPDGEKLLSSSS 197
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680505 233 TGRVLIWrgfgnrklalgnqkkkvramvDLdnagvrgedDAESCTTWHW-HSAEVNVLNFSSDGAYLYSGGREGVLVVWQ 311
Cdd:cd00200 198 DGTIKLW---------------------DL---------STGKCLGTLRgHENGVNSVAFSPDGYLLASGSEDGTIRVWD 247
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 30680505 312 LDTGKKKF-LPRIGSPLLYFMWSPDPTLSSVVCADNQIHL 350
Cdd:cd00200 248 LRTGECVQtLSGHTNSVTSLAWSPDGKRLASGSADGTIRI 287
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
278-634 |
1.77e-17 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 85.35 E-value: 1.77e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680505 278 TWHWHSAEVNVLNFSSDGAYLYSGGREGVLVVWQLDTGK-KKFLPRIGSPLLYFMWSPDPTLSSVVCADNQIHLLKMPSM 356
Cdd:COG2319 73 TLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLlLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATG 152
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680505 357 EILRTISGikpppslprmYEGLASTVAFDRSSGIAALCTENYCVQLYNLLNDRGISEIqvceRNHQPGdeitvvVTAVAL 436
Cdd:COG2319 153 KLLRTLTG----------HSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTL----TGHTGA------VRSVAF 212
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680505 437 SLDGSVMSTTEvklpEDGigglvSLKFWASEPDSKTFTLstivyePHRDAGVSAIVFHPTRSMAVSTSFGGDFKIWVCNS 516
Cdd:COG2319 213 SPDGKLLASGS----ADG-----TVRLWDLATGKLLRTL------TGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLAT 277
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680505 517 DKNQT--DKDSSWIchavgsykkkpmTAAAFSGDGTVMAVAAE-NVITLWNPDKNILLSVLGSTLTPITKLCFAGKSEFL 593
Cdd:COG2319 278 GELLRtlTGHSGGV------------NSVAFSPDGKLLASGSDdGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTL 345
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 30680505 594 VAASHipRPELSVWNTSKLSLswsyGLRIEAVTSAVDSSAF 634
Cdd:COG2319 346 ASGSD--DGTVRLWDLATGEL----LRTLTGHTGAVTSVAF 380
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
37-83 |
4.83e-04 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 38.45 E-value: 4.83e-04
10 20 30 40
....*....|....*....|....*....|....*....|....*..
gi 30680505 37 TGLQITSLEGHTAPVTTLIVVPASSpaqkilcYCWTASLDGTIRHWD 83
Cdd:smart00320 1 SGELLKTLKGHTGPVTSVAFSPDGK-------YLASGSDDGTIKLWD 40
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
38-83 |
2.51e-03 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 36.17 E-value: 2.51e-03
10 20 30 40
....*....|....*....|....*....|....*....|....*.
gi 30680505 38 GLQITSLEGHTAPVTTLivvpASSPAQKILCycwTASLDGTIRHWD 83
Cdd:pfam00400 1 GKLLKTLEGHTGSVTSL----AFSPDGKLLA---SGSDDGTVKVWD 39
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
3-440 |
7.20e-25 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 108.07 E-value: 7.20e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680505 3 RGGRSYVTSPPSFSNDAKKLLVCTGNTVSVFSAATGLQITSLEGHTAPVTTLivvpASSPAQKILcycWTASLDGTIRHW 82
Cdd:COG2319 75 LGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSV----AFSPDGKTL---ASGSADGTVRLW 147
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680505 83 DFSGPELLKTidaqlpiysmvipsllsepqqidkrrelsgklvayvsvedisvvnqgskeLRGHirrfnlaksriprgdt 162
Cdd:COG2319 148 DLATGKLLRT--------------------------------------------------LTGH---------------- 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680505 163 lkeTAEPESIVISPSGEFF---GIRHkcKIHIWDVPSGGSRHAVSrkmtlHHTKVINAFAFHPTERVIAAGDVTGRVLIW 239
Cdd:COG2319 162 ---SGAVTSVAFSPDGKLLasgSDDG--TVRLWDLATGKLLRTLT-----GHTGAVRSVAFSPDGKLLASGSADGTVRLW 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680505 240 rgfgnrklalgnqkkkvramvDLDNAGVRgeddaescTTWHWHSAEVNVLNFSSDGAYLYSGGREGVLVVWQLDTGK-KK 318
Cdd:COG2319 232 ---------------------DLATGKLL--------RTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGElLR 282
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680505 319 FLPRIGSPLLYFMWSPDPTLSSVVCADNQIHLLKMPSMEILRTISGikpppslprmYEGLASTVAFDRSSGIAALCTENY 398
Cdd:COG2319 283 TLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTG----------HTGAVRSVAFSPDGKTLASGSDDG 352
|
410 420 430 440
....*....|....*....|....*....|....*....|..
gi 30680505 399 CVQLYNLLNDRGISEIqvceRNHQPGdeitvvVTAVALSLDG 440
Cdd:COG2319 353 TVRLWDLATGELLRTL----TGHTGA------VTSVAFSPDG 384
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
3-314 |
1.28e-24 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 107.30 E-value: 1.28e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680505 3 RGGRSYVTSPpSFSNDAKKLLV-CTGNTVSVFSAATGLQITSLEGHTAPVTTLivvpASSPAQKILcycWTASLDGTIRH 81
Cdd:COG2319 117 TGHTGAVRSV-AFSPDGKTLASgSADGTVRLWDLATGKLLRTLTGHSGAVTSV----AFSPDGKLL---ASGSDDGTVRL 188
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680505 82 WDFSGPELLKTIDA-QLPIYSMVI-PSllsepqqidkrrelsGKLVAYVSvEDisvvnqgskelrGHIRRFNLAKSRIPR 159
Cdd:COG2319 189 WDLATGKLLRTLTGhTGAVRSVAFsPD---------------GKLLASGS-AD------------GTVRLWDLATGKLLR 240
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680505 160 gdTLK-ETAEPESIVISPSGEFF--GIRHKcKIHIWDVPSGGSRHAVSrkmtlHHTKVINAFAFHPTERVIAAGDVTGRV 236
Cdd:COG2319 241 --TLTgHSGSVRSVAFSPDGRLLasGSADG-TVRLWDLATGELLRTLT-----GHSGGVNSVAFSPDGKLLASGSDDGTV 312
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680505 237 LIW-----------RGFGN-----------RKLALGNQKKKVRaMVDLDNAGVRgeddaescTTWHWHSAEVNVLNFSSD 294
Cdd:COG2319 313 RLWdlatgkllrtlTGHTGavrsvafspdgKTLASGSDDGTVR-LWDLATGELL--------RTLTGHTGAVTSVAFSPD 383
|
330 340
....*....|....*....|
gi 30680505 295 GAYLYSGGREGVLVVWQLDT 314
Cdd:COG2319 384 GRTLASGSADGTVRLWDLAT 403
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
209-597 |
1.14e-21 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 98.44 E-value: 1.14e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680505 209 LHHTKVINAFAFHPTERVIAAGDVTGRVLIWrgfgnrklalgnqkkkvramvDLDNAGVRgeddaescTTWHWHSAEVNV 288
Cdd:COG2319 75 LGHTAAVLSVAFSPDGRLLASASADGTVRLW---------------------DLATGLLL--------RTLTGHTGAVRS 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680505 289 LNFSSDGAYLYSGGREGVLVVWQLDTGKKKF-LPRIGSPLLYFMWSPDPTLSSVVCADNQIHLLKMPSMEILRTISGikp 367
Cdd:COG2319 126 VAFSPDGKTLASGSADGTVRLWDLATGKLLRtLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTG--- 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680505 368 ppslprmYEGLASTVAFDRSSGIAALCTENYCVQLYNLLNDRGISEIqvceRNHQPGdeitvvVTAVALSLDGSVMSTTE 447
Cdd:COG2319 203 -------HTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTL----TGHSGS------VRSVAFSPDGRLLASGS 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680505 448 vklpEDGigglvSLKFWASEPDSKTFTLstivyePHRDAGVSAIVFHPTRSMAVSTSFGGDFKIWvcnsdknqtDKDSSW 527
Cdd:COG2319 266 ----ADG-----TVRLWDLATGELLRTL------TGHSGGVNSVAFSPDGKLLASGSDDGTVRLW---------DLATGK 321
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 30680505 528 ICHAVGSYKKKPmTAAAFSGDGTVMAVAAE-NVITLWNPDKNILLSVLGSTLTPITKLCFAGKSEFLVAAS 597
Cdd:COG2319 322 LLRTLTGHTGAV-RSVAFSPDGKTLASGSDdGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGS 391
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
94-566 |
3.67e-21 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 96.90 E-value: 3.67e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680505 94 DAQLPIYSMVIPSLLSEPQQIDKRRELSGKLVAYVSVEDISVVNQGSKELRGHIRRFNLAKSRIPRGDTLKETAEPESIV 173
Cdd:COG2319 6 GAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVA 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680505 174 ISPSGEFFGI-RHKCKIHIWDVPSGGSRHAVSrkmtlHHTKVINAFAFHPTERVIAAGDVTGRVLIWRGFGNRKLAlgnq 252
Cdd:COG2319 86 FSPDGRLLASaSADGTVRLWDLATGLLLRTLT-----GHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLR---- 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680505 253 kkkvramvdldnagvrgeddaesctTWHWHSAEVNVLNFSSDGAYLYSGGREGVLVVWQLDTGKKKFLPRIGSPLLYFM- 331
Cdd:COG2319 157 -------------------------TLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVa 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680505 332 WSPDPTLSSVVCADNQIHLLKMPSMEILRTISGikpppslprmYEGLASTVAFDRSSGIAALCTENYCVQLYNLLNDRGI 411
Cdd:COG2319 212 FSPDGKLLASGSADGTVRLWDLATGKLLRTLTG----------HSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELL 281
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680505 412 SEIQvcernHQPGDeitvvVTAVALSLDGSVMSTTEvklpEDGigglvSLKFWASEPDSKTFTLStivyepHRDAGVSAI 491
Cdd:COG2319 282 RTLT-----GHSGG-----VNSVAFSPDGKLLASGS----DDG-----TVRLWDLATGKLLRTLT------GHTGAVRSV 336
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 30680505 492 VFHPTRSMAVSTSFGGDFKIWvcnsdknqtDKDSSWICHAVGSYkKKPMTAAAFSGDGTVMAVAAE-NVITLWNPD 566
Cdd:COG2319 337 AFSPDGKTLASGSDDGTVRLW---------DLATGELLRTLTGH-TGAVTSVAFSPDGRTLASGSAdGTVRLWDLA 402
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
3-350 |
1.57e-18 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 86.62 E-value: 1.57e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680505 3 RGGRSYVTSPpSFSNDAKKLLVCTG-NTVSVFSAATGLQITSLEGHTAPVTTLIVVPASspaQKILCycwtASLDGTIRH 81
Cdd:cd00200 6 KGHTGGVTCV-AFSPDGKLLATGSGdGTIKVWDLETGELLRTLKGHTGPVRDVAASADG---TYLAS----GSSDKTIRL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680505 82 WDFSGPELLKTI-DAQLPIYSMVIpsllsepqqIDKRRELSGklvayvSVEDISVV------NQGSKELRGHirrfnlak 154
Cdd:cd00200 78 WDLETGECVRTLtGHTSYVSSVAF---------SPDGRILSS------SSRDKTIKvwdvetGKCLTTLRGH-------- 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680505 155 sriprgdtlkeTAEPESIVISPSGEF-FGIRHKCKIHIWDVPSGGSRHavsrkmTLH-HTKVINAFAFHPTERVIAAGDV 232
Cdd:cd00200 135 -----------TDWVNSVAFSPDGTFvASSSQDGTIKLWDLRTGKCVA------TLTgHTGEVNSVAFSPDGEKLLSSSS 197
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680505 233 TGRVLIWrgfgnrklalgnqkkkvramvDLdnagvrgedDAESCTTWHW-HSAEVNVLNFSSDGAYLYSGGREGVLVVWQ 311
Cdd:cd00200 198 DGTIKLW---------------------DL---------STGKCLGTLRgHENGVNSVAFSPDGYLLASGSEDGTIRVWD 247
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 30680505 312 LDTGKKKF-LPRIGSPLLYFMWSPDPTLSSVVCADNQIHL 350
Cdd:cd00200 248 LRTGECVQtLSGHTNSVTSLAWSPDGKRLASGSADGTIRI 287
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
278-634 |
1.77e-17 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 85.35 E-value: 1.77e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680505 278 TWHWHSAEVNVLNFSSDGAYLYSGGREGVLVVWQLDTGK-KKFLPRIGSPLLYFMWSPDPTLSSVVCADNQIHLLKMPSM 356
Cdd:COG2319 73 TLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLlLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATG 152
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680505 357 EILRTISGikpppslprmYEGLASTVAFDRSSGIAALCTENYCVQLYNLLNDRGISEIqvceRNHQPGdeitvvVTAVAL 436
Cdd:COG2319 153 KLLRTLTG----------HSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTL----TGHTGA------VRSVAF 212
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680505 437 SLDGSVMSTTEvklpEDGigglvSLKFWASEPDSKTFTLstivyePHRDAGVSAIVFHPTRSMAVSTSFGGDFKIWVCNS 516
Cdd:COG2319 213 SPDGKLLASGS----ADG-----TVRLWDLATGKLLRTL------TGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLAT 277
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680505 517 DKNQT--DKDSSWIchavgsykkkpmTAAAFSGDGTVMAVAAE-NVITLWNPDKNILLSVLGSTLTPITKLCFAGKSEFL 593
Cdd:COG2319 278 GELLRtlTGHSGGV------------NSVAFSPDGKLLASGSDdGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTL 345
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 30680505 594 VAASHipRPELSVWNTSKLSLswsyGLRIEAVTSAVDSSAF 634
Cdd:COG2319 346 ASGSD--DGTVRLWDLATGEL----LRTLTGHTGAVTSVAF 380
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
282-598 |
5.24e-17 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 82.38 E-value: 5.24e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680505 282 HSAEVNVLNFSSDGAYLYSGGREGVLVVWQLDTGKKKFLPRIGS-PLLYFMWSPDPTLSSVVCADNQIHLLKMPSMEILR 360
Cdd:cd00200 8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTgPVRDVAASADGTYLASGSSDKTIRLWDLETGECVR 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680505 361 TISGikpppslprmYEGLASTVAFDRSSGIAALCTENYCVQLYNLLNDRGISEIqvceRNHQPGdeitvvVTAVALSLDG 440
Cdd:cd00200 88 TLTG----------HTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTL----RGHTDW------VNSVAFSPDG 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680505 441 SVMSTTEVklpeDGigglvSLKFWasepDSKTFTLSTiVYEPHRDaGVSAIVFHPTRSMAVSTSFGGDFKIWVCNSDKnq 520
Cdd:cd00200 148 TFVASSSQ----DG-----TIKLW----DLRTGKCVA-TLTGHTG-EVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGK-- 210
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 30680505 521 tdkdsswiCHAVGSYKKKPMTAAAFSGDGTVMAVAAE-NVITLWNPDKNILLSVLGSTLTPITKLCFAGKSEFLVAASH 598
Cdd:cd00200 211 --------CLGTLRGHENGVNSVAFSPDGYLLASGSEdGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSA 281
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
211-512 |
2.68e-16 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 80.07 E-value: 2.68e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680505 211 HTKVINAFAFHPTERVIAAGDVTGRVLIWRGFGNRKLA-LGNQKKKVRAmVDLDNAGVR----GEDDA---------ESC 276
Cdd:cd00200 8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRtLKGHTGPVRD-VAASADGTYlasgSSDKTirlwdletgECV 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680505 277 TTWHWHSAEVNVLNFSSDGAYLYSGGREGVLVVWQLDTGKKKF-LPRIGSPLLYFMWSPDPTLSSVVCADNQIHLLKMPS 355
Cdd:cd00200 87 RTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTtLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRT 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680505 356 MEILRTISGikpppslprmYEGLASTVAFDRSSGIAALCTENYCVQLYNLlndRGISEIQVCERnHQPGdeitvvVTAVA 435
Cdd:cd00200 167 GKCVATLTG----------HTGEVNSVAFSPDGEKLLSSSSDGTIKLWDL---STGKCLGTLRG-HENG------VNSVA 226
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 30680505 436 LSLDGSVMSTTevklPEDGigglvSLKFWasepDSKTFTLSTIVYEPhrDAGVSAIVFHPTRSMAVSTSFGGDFKIW 512
Cdd:cd00200 227 FSPDGYLLASG----SEDG-----TIRVW----DLRTGECVQTLSGH--TNSVTSLAWSPDGKRLASGSADGTIRIW 288
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
7-240 |
4.85e-12 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 67.36 E-value: 4.85e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680505 7 SYVTSPpSFSNDaKKLLVCTG--NTVSVFSAATGLQITSLEGHTAPVTTLIVvpasSPAQKILCycwTASLDGTIRHWDF 84
Cdd:cd00200 94 SYVSSV-AFSPD-GRILSSSSrdKTIKVWDVETGKCLTTLRGHTDWVNSVAF----SPDGTFVA---SSSQDGTIKLWDL 164
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680505 85 SGPELLKTIDA-QLPIYSMVI-PsllsepqqiDKRRELSGKLVAYVSVEDISVVNQgSKELRGHIRRFNlaksriprgdt 162
Cdd:cd00200 165 RTGKCVATLTGhTGEVNSVAFsP---------DGEKLLSSSSDGTIKLWDLSTGKC-LGTLRGHENGVN----------- 223
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680505 163 lketaepeSIVISPSGEFF-GIRHKCKIHIWDVPSGgsrhavSRKMTLH-HTKVINAFAFHPTERVIAAGDVTGRVLIWR 240
Cdd:cd00200 224 --------SVAFSPDGYLLaSGSEDGTIRVWDLRTG------ECVQTLSgHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
278-687 |
3.82e-09 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 59.54 E-value: 3.82e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680505 278 TWHWHSAEVNVLNFSSDGAYLYSGGREGVLVVWQLDTGKKKF-LPRIGSPLLYFMWSPDPTLSSVVCADNQIHLLKMPSM 356
Cdd:COG2319 31 LLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLAtLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATG 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680505 357 EILRTISGikpppslprmYEGLASTVAFDRSSGIAALCTENYCVQLYNLLNDRGISEIqvceRNHQPGdeitvvVTAVAL 436
Cdd:COG2319 111 LLLRTLTG----------HTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTL----TGHSGA------VTSVAF 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680505 437 SLDGSVMSTTEvklpEDGigglvSLKFWASEPDSKTFTLstivyePHRDAGVSAIVFHPTRSMAVSTSFGGDFKIWvcNS 516
Cdd:COG2319 171 SPDGKLLASGS----DDG-----TVRLWDLATGKLLRTL------TGHTGAVRSVAFSPDGKLLASGSADGTVRLW--DL 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680505 517 DKNQT----DKDSSWIchavgsykkkpmTAAAFSGDGTVMAVA-AENVITLWNPDKNILLSVLGSTLTPITKLCFAGKSE 591
Cdd:COG2319 234 ATGKLlrtlTGHSGSV------------RSVAFSPDGRLLASGsADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGK 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680505 592 FLVAAShiprpelsvwntsklslswsyglrieavtsavdssafavlavipktfktdeskenifrgRDGAILLFNGSDPKP 671
Cdd:COG2319 302 LLASGS-----------------------------------------------------------DDGTVRLWDLATGKL 322
|
410
....*....|....*.
gi 30680505 672 VSIWTVMKARGGSISF 687
Cdd:COG2319 323 LRTLTGHTGAVRSVAF 338
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
37-83 |
4.83e-04 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 38.45 E-value: 4.83e-04
10 20 30 40
....*....|....*....|....*....|....*....|....*..
gi 30680505 37 TGLQITSLEGHTAPVTTLIVVPASSpaqkilcYCWTASLDGTIRHWD 83
Cdd:smart00320 1 SGELLKTLKGHTGPVTSVAFSPDGK-------YLASGSDDGTIKLWD 40
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
3-83 |
1.57e-03 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 41.17 E-value: 1.57e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680505 3 RGGRSYVTSPpSFSNDakKLLVCTG---NTVSVFSAATGLQITSLEGHTAPVTTLivvpASSPAQKILCycwTASLDGTI 79
Cdd:cd00200 216 RGHENGVNSV-AFSPD--GYLLASGsedGTIRVWDLRTGECVQTLSGHTNSVTSL----AWSPDGKRLA---SGSADGTI 285
|
....
gi 30680505 80 RHWD 83
Cdd:cd00200 286 RIWD 289
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
274-310 |
1.70e-03 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 36.91 E-value: 1.70e-03
10 20 30
....*....|....*....|....*....|....*..
gi 30680505 274 ESCTTWHWHSAEVNVLNFSSDGAYLYSGGREGVLVVW 310
Cdd:smart00320 3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
38-83 |
2.51e-03 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 36.17 E-value: 2.51e-03
10 20 30 40
....*....|....*....|....*....|....*....|....*.
gi 30680505 38 GLQITSLEGHTAPVTTLivvpASSPAQKILCycwTASLDGTIRHWD 83
Cdd:pfam00400 1 GKLLKTLEGHTGSVTSL----AFSPDGKLLA---SGSDDGTVKVWD 39
|
|
| |
